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How Does Malic Acid Help With Fibromyalgia?
August 22, 2011 12:37 PM
Fibromyalgia(FM) is a condition affecting primarily middle-aged women and is often misdiagnosed and misunderstood as an ailment which has a diverse set of symptoms, in which none are pleasant. It basically is a medical disorder defined by chronic and widespread pain, a heightened response to pressure and often time painful as well. No one really knows what the exact causes are. There are a number of studies taking place and done by reputable medical organisations (such as the Nation Institute of Arthritis and Musculoskeletal and Skin Diseases - NIAMS) which are geared towards the establishment, once and for all, of the route cause of Fibromyalgia. A part of the current scientific theories is the inherent genetic factor, but even in this it seems that geneticists are not clear as to which genes exactly may be the culprit. What has been concretely established and clarified though is that not just because your mom or dad has it you’ll have it. Stress in some studies has also been found as a contributor but may not be the main cause though.
Malic acid is an organic compound and also a carboxylic diacid and is an active ingredient in many sour or tart foods. It is mostly in unripe fruits and it has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of this diacid are called malates. The malate anion is an intermediate in the citric acid cycle. However it was not until 1785 that Carl Wilhelm Scheele first isolated it from apple juice. It is formed in metabolic cycles within the cells of plants animals and humans. A somewhat large amount of Malic Acid is produced and broken down in the body each day. Malic acid also provides stamina and endurance within the muscle cells. It is particularly useful in the blocking of aluminum toxics, which has been found to possibly be one contributing factors to fibromyalgia.
Compelling evidence has surfaced that malic acid may plays a central role in energy production, especially during hypoxic conditions. In some experiments that have been done, the improvement that came about when malic acid was administered to the subject was gone after discontinuing for 48 hours. The theory behind this is in the relative association of hypoxia to FM, if it will improve hypoxic conditions then it will be beneficial for FM sufferers as well just as Chronic Fatigue Syndrome has also been associated with FM. Additionally, many hypoxia related conditions, like respiratory and circulatory insufficiency, are related to deficiency in energy production as well. Therefore, malic acid may be of benefit in these conditions.
The mitochondria are the energy furnaces in cells which metabolize food for energy. Some findings suggest that this structure does not operate efficiently in those with FM. So, for the mitochondria to produce ample amounts of ATP, several nutrients are essential and Malic Acid is one of them. Imbalances in the mitochondria’s process can cause the body to switch from oxygen-based metabolism to the less efficient anaerobic metabolism and this would contribute to an abnormal buildup of lactic acid following even light exertion. This lactic acid buildup results in fatigue, weakness, pain and muscle spasms.
How Does Tart Cherry Work To Fight gout and Inflammation?
May 25, 2011 12:46 PM
Health Benefits Of Tart Cherry
Tart cherry may be the newest addition to the growing list of superfruits. This species of sour cherries have been cultivated for centuries, but only recently has research started to uncover its medicinal potential. It is believed to contain a larger number of phenolics and anthocyanins than its sweet counterparts. Plus, it has been linked to more studies in the past few years.
Prunus cerasus are species of cherries native to Europe and parts of Asia. Tart cherries have less than 10 varieties cultivated around the world, but they have steadily grown in popularity. There are two major cultivars: the bright red amarelle and the darker morello. Among the popular cultivars are Montmorency, Balaton, and Griotte de Kleparow.
Counteracts Pain Chemicals
Anthocyanins have long been associated with the alleviation of joint pains and related symptoms, and tart cherry are among the best sources of these organic compounds. Anthocyanins are actually pigments that give fruits such as apples and cherries their red coloration. As a general rule, fullness of color is directly proportional to the anthocyanin content of fruits. Cancer research on anthocyanins is considered unrivaled due to the availability and reliability of documented data. The anthocyanins found in tart cherries counteract the inflammatory mediators that initiate tumorigenesis, which are the same chemicals responsible for sensitizing joints to pain.
Promotes Purine Metabolism
Gout ensues when purine metabolites in the form of uric acid crystallizes and in the process triggers local inflammatory responses. High levels of uric acid in the blood may form into urate crystals anywhere, but often precipitate in the joints of the lower extremities. The big toe is particularly vulnerable to gout, but it may also manifest in the form of joint pains and kidney stones. Unfortunately, human beings lack a functional enzyme that breaks down uric acid and re-balance uric acid levels. This is when tart cherries come to the rescue. They contain phytochemicals that regulate purine metabolites and promote the excretion of uric acid.
Accelerates Muscle Recovery
It is a common belief in the nutraceutical industry that tart cherries are one of the best sources of antioxidants. Free radicals are natural by-products of cellular respiration, and they become so abundant during workout that the muscles begin to feel sore. It takes a longer time to recover from radical damage when the antioxidant defense of cells is compromised. The antioxidant profile of tart cherries enables the skeletal muscles to recuperate fast after intense physical exertion.
Improves Sleep Disorders
Tart cherries have been commercially touted to cure insomnia. While this remains to be proven, tart cherries are in fact excellent sources of melatonin, the primary hormone responsible for inducing sleep in response to dark environments. Sleep disorders may result from a variety of factors, including stress, and sudden lifestyle changes may interfere with the chemical reactions that govern our biological clock. Tart cherries provide a ready source of melatonin, which normalizes circadian rhythm and enables the brain to relax.
Fight back against gout and inflammation pain with Tart Cherry.
Spectro 3 and Spectro Multivitamin
May 21, 2005 10:20 AM
Comes in a large range of sizes.
Spectro Iron Free multivitamin 100ct
Spectro Iron Free Multivitamin 250ct
Spectro Iron Free Multivitamin 360ct
Spectro 3 multivitamin 180ct
Spectro 3 Multivitamin 90ct
Spectro 3 Iron Free multivitamin 180ct
Spectro 3 Iron Free multivitamin 90ct
Spectro Smoothie drink mix 720g
Spectro Vegetarian multivitamin 90ct
Spectro Vegetarian Multivitamin 180ct
Prosta Response - 45ct, 90ct, and 180ct --
May 20, 2005 07:36 PM
ookstores are filled with it, news magazines are reporting on it. From the revelations of politicians to disturbing statistical reports, prostate health issues that formerly received little notice are now in the headlines. The prostate is a walnut-sized gland located under the bladder and surrounding the urinary tract in men. Many factors affect prostate wellness, including aging and individual genetic history, but today’s chemicalized environment poses unprecedented challenges to the health of the prostate gland. Source Naturals is helping to meet this challenge with PRO STA RESPONSE, a Bio-Aligned Formula™ designed to support multiple, interdependent body systems. It is the only prostate formula that addresses six body systems involved with healthy prostate function.
More than Symptoms*, Systems PRO STA-RE SPONSE is a unique formula that combines clinically tested potencies of saw palmetto extract and beta sitosterol with standardized Swedish flower pollen extract, quercetin, lyopene, soy and additional herbs and nutrients. PRO-STA- RESPONSE goes beyond formulas that simply address nutritional symptoms and instead deals with underlying causes. PROSTARESPONSE supports healthy prostate function and urine flow by addressing the following body systems: 1. Hormone regulation: Hormones have a direct role in prostate functioning and have been closely linked to prostate health. PRO STA RESP ONSE contains specific plant extracts and nutrients shown in research to inhibit the conversion of testosterone to dihydrotestosterone (DHT), and the subsequent binding to receptors within the prostate. 2. Prostate cell regeneration: Swedish flower pollen extract, used extensively in Europe and Asia for more than 40 years, has demonstrated significant effects in maintaining proper prostate cell regeneration. 3. Soothing mechanisms: Certain plant compounds, such as flavonoids from soy and sterols from pollen extract, inhibit the metabolism of arachidonic acid. This in turn influences prostaglandin synthesis, which may be associated with comfort levels. 4. Bladder and urinary tract health: A healthy environment within the bladder and urinary tract is vital for prostate health and normal urine flow. PROSTARESPONSE contains botanicals that support the bladder and urinary tract health. 5. Prostate health: Studies show that dietary factors influence the overall health of the prostate. The body naturally concentrates certain compounds in higher amounts in the prostate. These include zinc, vitamin E and soy isoflavones. 6. Antioxidant defense: Antioxidants play an important role in maintaining prostate function and cell membrane integrity. Oxidative stress, or the action of free radicals, is confirmed as a significant factor that can trigger a host of destructive processes. Developing a Prostate-Friendly Lifestyle Supplementation is only one part of an individual’s Strategy for WellnessSM. That’s why Source Naturals® is committed to providing public education about the many aspects of a prostate-healthy lifestyle. Less Fat, More Fiber, Lots of Veggies Studies suggest a direct relationship between dietary fat and prostate health, with men whose diets consist of 30%-40% or more fat at highest risk. Saturated fats, especially from animal sources, are most problematic. Some research has attributed this relationship to the effect animal fats have on excess levels of circulating sex hormones. Prostate health is also associated with high fiber intake. This may be because dietary fiber binds testosterone, estradiol and other sex steroids and helps eliminate excess hormones,
Five to nine servings of high-fiber fruits, vegetables, beans and whole grains (35 g) are recommended daily for prostate health. Tomato-based foods are rich in the carotenoid, lycopene, which is a potent antioxidant, helping to protect our cells and fatty tissues from free radical damage. A long-term study at Harvard School of Medicine found beneficial effects from 10 servings of tomato products weekly, while recent clinical research points to an intake of 15 mg of lycopene twice per day. Also helpful are green and yellow-orange vegetables, which contain compounds that are converted to vitamin A; citrus fruits that contain vitamin C; nuts and seeds that contain vitamin E; zinc-containing seafood, legumes and eggs; and selenium-rich whole grains, seafood and organ meats. Studies show a correlation between prostate health and diets that contain large amounts of soy. Soybeans contain prostate-healthy phytoestrogens, including the isoflavone, genistein. Some experts suggest eating seven servings of soy protein per week (providing 10 g of soy protein and 20 mg of isoflavones daily) for general good health, and three times that amount for more targeted protection. Drink Healthy Dehydration stresses the prostate gland. It is important to consume plenty of water—about eight glasses per day. Plain water is best, but you can also drink highly diluted fruit juice, herbal tea or lightly flavored sparkling water. Green tea is beneficial for prostate health, due to certain antioxidant compounds called polyphenols.
You can reduce the frequency of nighttime trips to the bathroom by eliminating fluids a few hours before you go to sleep. You may find it more comfortable to spread out your intake, taking small sips of fluids over the course of the day. Exercise Good circulation is important for prostate health. Regular walking is excellent in this regard. “Kegel” exercises— a series of contractions of the muscles around the prostate—are helpful for improving circulation and tonicity of the genital area. Supplementation Supplementation tailored to prostate wellness would focus on the vitamins and minerals described above—in addition to nourishing our body systems, many are also antioxidants, helping to counter the free radical damage that is rampant in our chemicalized environment. The program would also include specific herbs found to support prostate function, especially saw palmetto, pygeum, and pumpkin seeds. First Bio-Aligned Formula for the Prostate Gland! PROSTA-RESPONSE is the first prostate support formula designed to work holistically, by addressing the multiple systems that affect prostate higher amounts in the prostate. health.
Try Source Naturals PRO STA-RE SPONSE, available in bottles of 45 and 90 tablets.
Hormonal Regulation Freeze Dried stinging Nettle, Pygeum, Red Clover, Saw Palmetto, Soy, Swedish Flower Pollen Extract, Zinc, Vitamin D-3 Prostate Cellular Regeneration Lycopene, Nettle, Quercetin, Red Clover, Swedish Flower Pollen Extract, Vitamin D-3 Soothing Mechanisms: Prostaglandin Synthesis Beta Sitosterol, Pygeum, Quercetin, Red Clover Saw Palmetto, Soy, Swedish Flower Pollen Extract Bladder & Urinary Tract Health Alanine, Glutamic Acid, Glycine, Goldenseal, Gravel Root, Marshmallow Root, Pumpkin Seed, Pygeum, Swedish Flower Pollen Extract, Uva Ursi Prostate Health Red Clover, Soy, Zinc, Vitamin E Antioxidant Defense Ginkgo Biloba, Grape Seed, Green Tea, Lycopene, Pygeum, Quercetin, Red Clover, Soy, Swedish Flower Pollen Extract, Selenium, Zinc, Vitamin E PROSTA-RESPONSE™: A Bio-Aligned Formula™ Multi-System Support for the Prostate Gland References Buck, A.C. 1996. Phytotherapy for the prostate. Brit J Urol 78:325-336. Morton, M.S. et al. Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom. Prostate 32:122-128. Morton, M.S. et al. 1996. The preventative role of diet in prostatic…Brit J Urol 77:481-493. Wilt, T.J. et al. 1998. Saw palmetto extracts…a systematic review. JAMA 280:1604-1609 Yasumoto, M.D. et al. Jan-Feb 1995. Clinical evaluation of long-term treatment using …pollen extract…Clin Ther 17(1):82-87. *The term symptom as used in this literature refers to the effects of nutrient imbalances and shortages, and is not related to the diagnosis, treatment, cure, or prevention of any disease.
Prosta Response 45ct
Prosta Response 90ct
Prosta Response 180ct
VitaNet® VitaNet ® Staff
Prosta Response -- Supports proper prostate function!
May 20, 2005 07:28 PM
Prosta-Response is a Bio-Aligned Formula that supports multiple body systems involved with the health of the prostate - a walnut-sized gland located under the bladder and surrounding the urinary tract in men. Prosta-Response supports hormonal regulation, cellular regeneration, antioxidant defense, the bladder and urinary tract, and the body's natural soothing mechanisms. It contains clinically researched amounts of saw palmetto extract and beta-sitosterol, plus quercetin, soy, and lycopene. These antioxidants and compounds, along with essential vitamins and minerals, help maintain tissue and cell integrity, which are vital to prostate health.
Prosta Response 45ct
Prosta Response 90ct
Prosta Response 180ct
VitaNet® VitaNet ® Staff
May 20, 2005 05:33 PM
Between 10 and 15 million American men experience challenges to libido and sexual performance, according to the National Institutes of Health. Fatigue, stress, inactivity and an unhealthy diet can result in decreased vigor and desire. In addition, the normal aging process may result in a slowing of response, according to the National Institute on Aging. MALE RESPONSE is a Bio-Aligned Formula™ that helps bring alignment to a range of interrelated body systems that can negatively impact male sexual function: hormonal function, energy generation, circulation, the brain and nervous system, and the prostate gland.
Bio-Aligned Formula™ MALE RESPONSE is a comprehensive herbal-nutrient formula that supports the multiple, interconnected systems involved with male sexual function. Hormonal Function Hormones are chemicals released into the bloodstream that control numerous body functions. Testosterone is the most important of the male sex hormones. Produced by the testes, it is responsible for the development and maintenance of the male sex organs, contributes greatly to the level of sexual desire, and helps regulate energy and mood. MALE RESPONSE contains herbs and nutrients that may support hormonal function, including nettles, Panax ginseng, saw palmetto, tribulus, zinc, and vitamin B-5. Energy Generation Fatigue and poor energy can takes a toll on one’s desire or capacity for sexual intimacy. Male Response combines a variety of herbs and nutrients to help revitalize energy levels, nourish the adrenals, and/or invigorate the sexual response. These include ashwagandha, Panax ginseng, Siberian ginseng, zinc, and vitamins B-5 and B-6. Circulation Proper circulation of blood is vital for male sexual response. MALE RESPONSE contains several herbs known for their effect on blood flow. For example, yohimbe contains yohimbine, an alkaloid from the bark of a native African tree, which can stimulate selected portions of the nervous system and increase blood flow to enhance the sexual response. Additional ingredients that support healthy circulation include ginger, ginkgo, and vitamin E. Brain and Nervous System: Libido Stress and emotions often affect sexual desire and libido. MALE RESPONSE provides supportive nutrients for the healthy functioning of the nervous system, including copper, and vitamins B-5 and B-6. In addition, it contains herbs traditionally known for their aphrodisiac and/or rejuvenating properties. These include ashwagandha, avena sativa (oats), Panax ginseng, tribulus, and yohimbe.
Prostate Gland A healthy reproductive system is an important part of a balanced approach to sexual function. Specific ingredients such as zinc support male reproductive health and are essential for the properfunctioning of the prostate gland. Vitamin E, an antioxidant, supports normal prostate tissue functioning and sperm production. Additional support is provided by nettle, saw palmetto, and tribulus. Lifestyle Tips for Healthy Male Response: A Strategy for WellnessSM • Eat well: Diet is perhaps the most significant single factor in generating virility. A diet rich in whole foods, with adequate protein from sources such as fish, chicken, turkey, lean beef, tofu or legumes, is crucial. The prostate gland contains high amounts of zinc, which is needed for sperm production and healthy testosterone levels. Foods high in zinc include seafood, meat, root vegetables, legumes, pumpkin seeds, nuts and whole grains. It is also important to follow a low-fat, low-cholesterol diet, since elevated cholesterol levels and the resulting buildup of plaque in blood vessels, can affect male reponse by impairing blood flow. • Stop using tobacco. Nicotine, tobacco’s active ingredient, constricts the small blood vessels, interfering with healthy circulation. • Use alcohol in moderation and avoid illicit drugs. Alcohol is a nervous system depressant, which can interfere with sexual function. Steady drinking can inhibit male response by inhibiting blood flow. • Get moving. Moderate, but not extreme, amounts of exercise help you relax, boost your energy levels, increase your physical awareness and ultimately stimulate your sexuality. Regular exercise has an impact on vasocongestion, raising blood supply to the organs, while walking, stretching, swimming and resistance exercise help raise testoterone levels. • Contact a counselor. Counseling can help reduce the anxiety often associated with male performance. It can also address issues at work or home that may be contributing factors.
References Comas, M. et al. Bromatological study of maca. (Lepidium meyenii). Alimentaria 1997, 35(286): 85-90. Dini, A. et al. Chemical composition of Lepidium meyenii. Food Chemistry 1994, 49(4):347-9. Kapoor, L.D. Tribulus—indications and use. CRC Handbook of Ayurvedic Medicinal Plants. Boca Raton: FIAC/FASP; 1990. Physicians’ Desk Reference, 52 ed. Montvale, N.J.:Medical Economics Co.; 1998. Physician’s Desk Reference Medical Dictionary. Baltimore:Williams & Wilkins; 1995.
Male Response 45 tab
Male REsponse 90ct
Fenugreek and Cinnamon to lower blood sugar ...
May 18, 2005 09:27 AM
Fenugreek and cinnamon have had extensive studies devoted to their anti-diabetic properties. The major action of fenugreek may be via blockage of glucose absorption . Cinnamon has been shown to have insulin-like action  and affect insulin signalling . There is little association of diabetes treatment with cumin, pumpkin seed and oregano , although animal studies do suggest that cumin may lower circulating lipid levels in diabetic rats . The long-term safety of these condiments in the food supply suggests the possibility of daily use over the long haul to prevent or ameliorate insulin resistance and perhaps even increase useful lifespan [1,41]. Previous studies with other natural products have suggested this potential . Future studies are necessary to test the veracity of this hypothesis.
Control blood sugar and possibly increase or extend quality of Life and length of life.
Additional Supplements to lower Blood sugar.
May 18, 2005 09:24 AM
example, supplementary niacin-bound chromium [20,21], garlic , soluble fibres  and vanadium  can overcome, to some extent, many of these perturbations. Thus, natural nutrients/elements have the potential to favourably influence the glucose/insulin system and the onset of age-related chronic disorders with little threat of serious adverse side effects . We should mention that it is possible that proper combinations of these natural products may give even better risk/benefit ratios than single agents alone.
Gluco Science to lower Blood sugar 60ct
Gluco science to lower blood sugar 90ct
Gluco science to Lower Blood Sugar 180ct
VitaNet ® Staff
Block the Absorption of Carbs in the intestinal track.
May 17, 2005 02:39 PM
Carb-X™ dietary supplement features 600 mg white kidney bean extract, along with 200 mg wheat inhibitor extract, per two capsules. Both extracts have been studied for their potential ability to support the inhibition of amylase, the enzyme created by the body to break down sugars and carbohydrates. Amylase inhibitors bind and inactivate this enzyme so carbohydrates and sugars pass through without breaknig down. Carb-X ™ dietary supplement formula is a new revolutoinary aid to dieting. When combined with the NaturalMax® Diet Plan, it can help decrease calories from carbohydrates.
Carb X from Natural max 90ct
Carb X from Naturalmax 60ct
Carb X Shake mix Chocolate
Carb X Shake Mix Vannilla
Carb X with MCT Oil 60ct
Carb X Chewables 30ct
May 13, 2005 06:45 PM
L-5-Hydroxytryptophan treatment of sleep terrors in children.
Bruni O, Ferri R, Miano S, Verrillo E.
Centre for Paediatric Sleep Disorders, Department of Developmental Neurology and Psychiatry, University of Rome "La Sapienza", Via dei Sabelli 108, 00185 Rome, Italy. firstname.lastname@example.org
To test the hypothesis that the administration of L -5-hydroxytryptophan (L -5-HTP) might exert beneficial effects on sleep terrors, we carried out an open pharmacological trial in a group of children with sleep terrors compared to a group of children with the same disorder but without L -5-HTP treatment. Participants in the trial were 45 children (34 males and 11 females; age range 3.2-10.6 years), referred to the Sleep Centre of the Department of Developmental Neurology and Psychiatry of the University of Rome "La Sapienza", affected by sleep terrors. All subjects underwent: (1) complete medical and sleep history; (2) complete neurological examination and EEG recording whilst awake and sleeping, (3) a structured sleep diary for 2 months, (4) after 1 month, all subjects were examined again from the clinical and EEG points of view and (5) after 6 months, a structured interview in order to evaluate the clinical outcome. After the first visit, L -5-HTP was administered (2 mg/kg per day) at bedtime to 31 randomly selected patients for a single period of 20 consecutive days. After 1 month of treatment, 29/31 (93.5%) of patients showed a positive response. In the comparison group without drug therapy, after 1 month, the episodes disappeared only in four children (28.6%) while ten children (71.4%) showed the persistence of episodes with the same frequency as before. After 6 months, 26/31 (83.9%) of children treated with L -5HTP were sleep terror-free, while in five children (16.1%) sleep terror episodes persisted. Of the children in the comparison group, ten (71.4%) continued to show sleep terrors at 6-month follow-up. CONCLUSION:to our knowledge, this is the first study demonstrating the efficacy of a new drug treatment for sleep terrors. These results confirm our initial hypothesis and represent evidence that treatment with L -5-hydroxytryptophan is able to modulate the arousal level in children and to induce a long-term improvement of sleep terrors. Copyright 2004 Springer-Verlag
L-Tryptophan 500mg 90ct
Acute administration of red yeast rice depletes tissue CoQ10
May 13, 2005 03:00 PM
Basically, if you are taking a Cholesterol lowering product that works on the same order as prescription drugs, you need to supplement CoQ10 to replace what the body is removing.
British Journal of Nutrition (2005), 93, 131–135 DOI: 10.1079/BJN20041285 q The Authors 2004
Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q10 levels in ICR mice
VitaNet ® staff
Important Information for Allergy Sufferers
May 13, 2005 09:52 AM
Important Information for Allergy SufferersRichard Conant, L.Ac. C.N.
Imagine you are one among millions who greet each spring with worry about the flood of pollen that fills the air this time of year. When the pollen season arrives, as it inevitably does, you find yourself with two choices. You can either take over-the-counter antihistamines and put up with unpleasant side-effects, or endure the sneezing, runny nose, itchy, watery eyes and other discomforts of hay fever.
If there was a natural ingredient, a nutritional substance found throughout nature in many foods and plants, that could offer an alternative, would you not be interested?
Quercetin, one among hundreds of flavonoids found throughout the plant kingdom, is this ingredient. Quercetin has been researched in numerous pharmacological studies. The results of this work strongly suggest that quercetin helps to stabilize the fundamental process in the body which causes an allergic reaction. Quercetin, as shown in test-tube ("in vitro") studies, prevents the release of histamine from "mast cells," immune cells that stand guard in the tissues which meet the outside environment—the nasal passages, the lungs, the digestive tract and skin. While this has yet to be confirmed by human clinical trials, in the picture that emerges from the research so far, quercetin looks like a rescue nutrient for allergy sufferers.
Reports from Quercetin Users
I have seen numerous reports from individuals who have indeed achieved significant reductions in allergic sensitivity by using quercetin. And this includes food allergies as well as environmental allergies. Anecdotal stories like these carry little weight among scientists, because they do not provide evidence that the observed result will be repeated in other cases. Only placebo-controlled, double-blind studies can produce this kind of scientific proof. Yet, when anectodal evidence (this includes physician "case reports") correlates with the results of pharmacological research such as we have on quercetin, I believe it should be taken seriously. And quercetin is a nutrient that works effectively when taken as a dietary supplement.
For example, one gentleman writes that his wife, who is allergic to pollen and dust, is now "sneeze-free" after using quercetin for three years. A Pennsylvania woman writes that her husband, also a long time allergy sufferer, "seems to be nearly allergy free" after one month of use. Another man says that "quercetin has literally changed my life." These are not isolated cases; a respected nutritionist who specializes in allergies and environmental problems has seen many similar outcomes with a quercetin. Clearly something significant is going on with respect to quercetin as a nutritional approach for overcoming allergies.
Bear in mind, though, that quercetin does not function like an antihistamine medication; it is not a quick fix. As a nutrient that helps to normalize body functions naturally, quercetin needs time to work, and should be taken for at least two or three weeks to achieve these results.
Exerting a broad range of biological effects, quercetin is perhaps the most active and versatile flavonoid. In test-tube studies, quercetin acts directly on the mast cell in a way that quiets the allergic response.
An allergic reaction occurs when IgE antibodies, positioned on the mast cell surface, come in contact with a potential allergy-causing substance like pollen. The mast cell is then signaled to release histamine from storage granules located inside the cell, through a process called "degranulation." The histamine circulates throughout the body, causing the runny nose, itching and other discomforts associated with allergies.
Quercetin stabilizes mast cell membranes, in effect turning down the allergic response signal. Quercetin also slows other mechanisms which are involved with inflammation, such as the production of inflammatory prostaglandins and leukotrienes. This adds to its membrane-stabilizing effect, and its value in allergy control.
Quercetin appears to substantially raise the threshold for initiation of an allergic reaction. In allergy sufferers this threshold is low, for reasons which are not well understood. They may have more IgE antibodies than normal, making the mast cells overly "trigger happy." Histamine has its proper place in the immune response that defends us against truly harmful foreign substances in the body. But like many chemicals produced by the body, histamine is a two-edged sword. In allergy-prone individuals, the mast cells have become overreactive, releasing too much histamine, unnecessarily. With quercetin in the bloodstream, histamine release from mast cells is kept under control. Quercetin's ability to down-regulate both the inflammatory and allergic responses makes it, I believe, a highly important nutrient for humans to consume on a regular basis.
Quercetin-the Scientific Evidence
Several studies, published in respected journals such as the Journal of Allergy and Clinical Immunology and others, have demonstrated quercetin's ability to control the release of histamine from mast cells. (Quercetin has the same effect on basophils, a type of white blood cell that also contains histamine.) In these experiments, mast cells taken from both animals and humans are exposed in the test tube to various substances—called "antigens"— that stimulate histamine release. The researchers then add an inhibiting agent such as quercetin to the mixture and measure the differences in histamine output. Quercetin has shown itself to be one of the more powerful histamine inhibitors, more powerful, in fact, than disodium cromoglycate, an anti-asthma drug.
Quercetin has other beneficial properties. A strong antioxidant, Quercetin has a higher level of antioxidant activity than both vitamin C and vitamin E. (Quercetin enhances the antioxidant activity of vitamin C; quercetin and vitamin C are true synergists.) Quercetin has been shown to block the oxidation of LDL cholesterol by free radicals. Quercetin also protects cell membranes from being injured by oxidized LDL. The damage that oxidized LDL causes to the delicate membranes of blood vessel linings allows plaque deposits to form, setting the stage for atheroslcerosis. These observations point to quercetin as a key nutrient for maintaining cardiovascular health.
Like all flavonoids, quercetin is not classified as an essential nutrient, although flavonoids were once called "Vitamin P." In view of its many beneficial actions, quercetin is a nutrient that clearly has important roles to play in human nutrition, for allergy sufferers, and for everyone.
May 12, 2005 01:08 PM
Guggul – New Benefits for Heart Health
May 11, 2005 09:00 PM
Gum Guggul–New Benefits for Heart Health from an Age-Old Herbby Richard Conant, L.Ac., C.N.
The 1990's have seen a growing interest in herbs from India's ancient Ayurvedic tradition. One Ayurvedic herb in particular, "gum guggul," stands at the forefront, thanks to its rather remarkable benefits for the heart and cardiovascular health. A relative of myrrh and frankincense, gum guggul is a resin tapped from India's Commiphora mukul tree. Known more commonly in the Far East as simply "guggul," the herb has proven to be one of the most effective natural cholesterol-lowering agents ever discovered. Cholesterol reductions with guggul can be twenty percent or higher, and the herb also raises HDL, the more beneficial form of cholesterol. Studies also show guggul may help prevent atherosclerosis, by retarding the formation of fatty, cholesterol-laden deposits in blood vessel tissues.
Recent research on guggul has revealed that guggul also blocks the oxidation of LDL cholesterol, by acting as an antioxidant. LDL, which carries cholesterol from the liver to the rest of the body, is generally regarded as a key element in the development of atherosclerosis. But only when it is oxidized by free radicals does LDL accumulate in arteries. It its unoxidized or "native" state, LDL is more or less benign. Checking LDL oxidation is vital to keeping blood vessels free of plaque.1 (This is one of the major reasons why antioxidants are so important.) Guggul, by both lowering blood cholesterol and acting against LDL oxidation, now stands out as one of the world's most valuable herbs for heart health.
Guggul first caught the attention of the scientific world in1966, thanks to an Indian medical researcher who submitted a doctoral thesis on gum guggul.2 Her interest had been kindled by references to the herb in a centuries-old Ayurvedic text. Apparently, poor cardiovascular health and atherosclerosis were a problem back then just as they are today. Translated from Sanskrit, this text describes, in elegant detail, a condition called "coating and obstruction of channels." The cause, according to the ancient writers? Faulty metabolism due to overeating of fatty foods and lack of exercise. Death was said to be the end result of leaving this condition uncorrected. The recommended treatment plan emphasized diet and herbs, chiefly gum guggul.3
References to guggul in ancient literature actually go back even farther. The herb is mentioned in the Vedas, the holy scriptures of India believed to be anywhere from 3,000 to 10,000 years old. One stanza is translated as follows: "Disease (consumption) does not afflict and the curse never affects whom the delicious odor of the healing Guggul penetrates (spreads). The diseases also flee away in all directions from him like horses and deer, O Gugulu! Either born from Sindhu or from the sea. I chant your name for the removal of diseases."3
Struck by the obvious similarity between "coating and obstruction of channels" and atherosclerosis, the Indian researcher decided to study gum guggul's effect on blood fats in rabbits. Over a two-year period, the animals were fed hydrogenated vegetable oil to artificially raise their cholesterol levels. Guggul was administered to one group of rabbits, while the rest served as controls. At the end of the study the rabbits given guggul had normal cholesterol and blood lipid levels. Their arteries showed no fatty streaks or plague deposits. This caught the attention of the Indian scientific community, and numerous clinical trials ensued, both on animals and humans. In study after study, guggul consistently produced substantial reductions in cholesterol and triglyceride levels, while raising HDL.
The active ingredients in guggul are a group of natural plant sterols. Among these, substances called "guggulsterones" are the most important ingredients for the cholesterol and blood fat lowering properties of guggul, with the other sterols acting as a synergistic supporting cast.4 A number of mechanisms are suggested, although not definitely proven, for how the herb works; these include reducing the synthesis of cholesterol in the liver, enhancing cholesterol removal from the gut, stimulating thyroid function and increasing the number of receptors in the liver for uptake of LDL.3,5
Guggul extracts are now standardized for guggulsterone content. The herb naturally contains about 2 percent guggulsterones. Quality extracts contain a minimum of 2.5 percent, which assures the user is getting a product potent enough to produce results. Since the late 1980's clinical trials have used the standardized extract.6,7,8 The product is readily available in the U.S.
The ability of guggulsterones to prevent oxidation of LDL was discovered in a 1997 study done by scientists at the Central Drug Research Institute in Lucknow, India.9 This study sheds light on how guggul works against "coating and obstruction of channels." Remember that oxidized LDL forms the plaque that coats and eventually obstructs blood vessels. The researchers mixed LDL from human blood with a free radical promoting agent, either alone or in combination with guggulsterones. Samples were then analyzed for the presence LDL oxidation byproducts. The results showed that guggulsterones strongly protect LDL from being oxidized. Guggulsterones block the formation of hydroxyl radicals, a potent type of free-radical that attacks cell membranes.
Guggulsterones may also help keep the heart muscle itself healthy. When the heart muscle is deprived of oxygen, a condition known as "myocardial ischemia," it can be severely damaged by free radicals. The body tries to counter this with SOD, a key enzyme present in cells that neutralizes free radicals. SOD levels are significantly reduced in damaged heart tissues. Guggulsterones have been found to reverse this decrease by more than two-fold.10
Like the writer of that age-old verse found in the Vedas, contemporary herbalists hold gum guggul in the highest regard. Backed as it is by scientific research linked to centuries of traditional use, gum guggul has a bright future as a natural resource for maintaining normal cholesterol and blood fats, and for protecting heart health.
1. Heinecke, J.W. Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radical Biology & Medicine 1987;3:65-73.
2. Satyavati, G.V. Effect of an indigenous drug on disorders of lipid metabolism with special reference to atherosclerosis and obesity (Medoroga) M.D. thesis (Doctor of Ayurvedic Medicine). Banaras Hindu University, varanasi, 1966.
3. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.
4. Dev, S. A modern look at an age-old Ayurvedic drug-guggulu. Science Age July 1987:13-18.
5. Singh, V. et. al. Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. Pharmacological Research 1990;22(1):37-44.
6. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.
7. Agarwal, R.C. et. al. Clinical trial of gugulipid-a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.
8. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.
9. Singh, K., Chandler, R. Kapoor, N.K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytotherapy Research 1997;11:291-94.
10. Kaul, S. Kapoor, N.K. Reversal of chnages of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. Indian Journal of Experimental Biology 1989;27:625-627.
New Larger Size Red Yeast Rice with CoQ10 90ct
May 10, 2005 12:43 PM
Red Yeast Rice Plus CoQ10 90ct
Red Yeast Rice is manufactured by the fermentation of a strain of yeast, Monascus Purpureus, on rice and has been used traditionally by the Chinese as a flavoring and a good preservative. Because Red Yeast Rice may reduce CoQ10 levels, it may be important to supplement with CoQ10 at the same time as Red Yeast Rice and CoQ10.
May 09, 2005 11:35 AM