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  Messages 1-59 from 59 matching the search criteria.
14 vitamins help manage fibromyalgia Darrell Miller 5/18/19
Omega-3s associated with a reduced risk of bleeding in surgery, according to a new study Darrell Miller 5/10/19
Curcumin stops cancer cell growth, NEW scientific discovery Darrell Miller 4/27/19
CBD Oil & Hemp Oil – Cannabidiol help your health and wellbeing Darrell Miller 2/19/19
Curcumin Possesses ability to repair brain damage caused bystrokes Darrell Miller 2/15/19
Homeopathy 101: How autoimmune disorders begin and how to treatthem holistically Darrell Miller 2/1/19
Diabetes: Cinnamon (Dalchini) May Help Control Blood Sugar Levels Darrell Miller 1/30/19
Boswellia extract exhibits profound healing and anti-inflammatory properties Darrell Miller 1/19/19
Almonds are good for your heart, brain, AND stomach Darrell Miller 11/21/18
Some Using CBD Oil to Help Pets Reduce Stress, Anxiety Darrell Miller 7/9/18
A natural sugar molecule, D-ribose, found to improve heart function and blood flow Darrell Miller 7/4/18
What You Should Know About CBD Oil Darrell Miller 5/25/18
4 Groundbreaking Studies on Cannabis and Disease Darrell Miller 11/17/17
Wheat Germ Oil and Fish Oil Combination Benefits In Hemodialysis Patients Darrell Miller 9/8/17
Fish Oil Supplements: Are They Good for Cardiovascular Health? Darrell Miller 3/23/17
Garlic helps lower cholesterol in diabetes patients Darrell Miller 3/20/17
Cannabidiol (CBD) Inhibits Cancer Growth According to Medical Researchers, Announces Phillip Fry Darrell Miller 3/12/17
Vitamin C is a powerful heart healer, especially after surgery Darrell Miller 2/13/17
'Red Yeast Rice' Statin Alternative Not Harmless Either, Study Says Darrell Miller 2/2/17
Which Vitamins are Good for Dry Eyes? Darrell Miller 1/28/17
Natural Allopathic medicine: the power to heal and cure cancer Darrell Miller 1/4/17
Tired? Weak? You're not 'just getting old'; something is wrong Darrell Miller 12/27/16
Most Americans Have Inadequate Intakes of Vitamins and Minerals: Can Supplements Help? Darrell Miller 12/22/16
High-dose vitamin C reduces inflammation in cancer patients, study shows Darrell Miller 12/7/16
Insights on the link between kidney damage and cognitive impairment Darrell Miller 12/4/16
Reducing salt intake may help protect kidney patients’ heart and kidney health Darrell Miller 12/3/16
Vitamin D levels tied to breast cancer survival Darrell Miller 11/21/16
Is Coconut Oil A Brain Food? Darrell Miller 1/26/14
What Makes St Johns Wort Good For Depression And Anxiety? Darrell Miller 9/18/12
What Makes Curamed such a good Pain Remedy? Darrell Miller 10/24/11
Herbs For Depression Darrell Miller 12/13/10
Garcinia, Hydroxycitric acid and weight loss Darrell Miller 12/3/09
L-Methionine Darrell Miller 5/2/09
Huperzine And Memory Darrell Miller 12/4/08
Feverfew Leaves Darrell Miller 7/31/08
Shark Cartilage Darrell Miller 4/30/08
Take Charge Of Your Health With Herbal Bio-Identical hormones Darrell Miller 11/4/07
Lutein - A plant pigment provides sun protection from the inside out. Darrell Miller 7/9/07
Papaya- May Be A Fountain of Youth Darrell Miller 5/31/07
Safe Solutions for Chronic Pain Darrell Miller 3/30/07
Growing Older, Feeling Better Darrell Miller 3/28/07
Neurological Health and CoQ10 Darrell Miller 2/25/07
Fruit and Vegetable Lightning drink mixes from Natures Plus Darrell Miller 2/6/07
Mushrooms are good for the Immune System Darrell Miller 1/26/07
Benefits of L-Carnitine Darrell Miller 2/12/06
Benefits of Acetyl-L-Carnitine Darrell Miller 2/12/06
B Vitamins Avert Stroke, Coronary Disease, Death Darrell Miller 1/25/06
Astragalus Fact Sheet Darrell Miller 12/7/05
All SAM-e supplements are not created equal Darrell Miller 10/26/05
8 Steps for Relieving Back Pain Darrell Miller 8/2/05
<b>ARTIFICIAL SWEETENERS: CAUSE FOR WORRY</b> Darrell Miller 7/15/05
Pain - Post Op and Relaxation Darrell Miller 7/13/05
ALPHA GPC - Improves Mental Performance Darrell Miller 6/28/05
CLINICAL APPLICATIONS OF CAPSICUM Darrell Miller 6/23/05
GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient .... Darrell Miller 6/21/05
Defeat Depression Darrell Miller 6/13/05
The Flex Factor Darrell Miller 6/11/05
Multidophilus 180ct ... Darrell Miller 5/18/05
Bee Propolis may limit production of DHT... Darrell Miller 5/17/05




14 vitamins help manage fibromyalgia
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Date: May 18, 2019 10:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 14 vitamins help manage fibromyalgia





Fibromyalgia is a widespread medical condition and everyday new vitamins and supplements are discovered that can help alleviate it. Fibromyalgia causes pain and depression. Its pain is usually felt in the musculoskeletal system. It also causes depression in the brain and many other symptoms. That is why very few therapies have been discovered to use for treating this condition. Supplements are being recommended to patients. Some of them are essential oils that can help with pain relief and improving sleep, energy boosters that increase the level of energy in the body, and fish oils that can reduce the inflammation it causes. Fibromyalgia can be triggered by a deficiency in some minerals in the body, so one needs to avoid this. The essential vitamins and minerals that are needed in the body to prevent fibromyalgia are calcium, iron, magnesium, manganese, and vitamin D. Therefore, one needs to take active measures to have these essential vitamins and minerals in his body to prevent fibromyalgia. They are very important, especially increasing the intake of Vitamin D through sunlight.

Key Takeaways:

  • Supplementing with vitamins and minerals is critical in controlling the pain and depression associated with fibromyalgia.
  • Vitamin D supplementation is generally recommended in fibromyalgia patients, especially those that are menopausal or pre-menopausal.
  • According to Korean researchers, low levels of magnesium, calcium, and manganese are related to fibromyalgia.

"Everyday vitamins and minerals take on a whole new level of importance if a person is afflicted with fibromyalgia."

Read more: https://www.naturalnews.com/2019-04-14-vitamins-help-manage-fibromyalgia.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6336)


Omega-3s associated with a reduced risk of bleeding in surgery, according to a new study
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Date: May 10, 2019 02:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Omega-3s associated with a reduced risk of bleeding in surgery, according to a new study





A new study called the Omega-3 Fatty Acids for the Prevention of Post-Operative Atrial Fibrillation, also known as OPERA, is calling into question the conventional wisdom that patients who use omega-3 supplements right before surgery are at a higher risk of internal bleeding as a result. The study involved over 1,500 heart surgery patients, and found that those with the highest omega-3 levels in their blood were actually at a lower risk of bleeding. While the exact cause of this is not well understood, it does suggest that more research is needed.

Key Takeaways:

  • Although fish oil are very popular natural supplements that are good for heart health, in cases of surgey, they might cause blood thinning which is dangerous.
  • A new study has shown that the belief that taking fish oil before surgery is wrong is absolutely erroneous but that it reduces the risk of bleeding.
  • The study that discovered this new finding involved a large group of 1,516 persons who were divided into one group taking omega-3 supplements and another taking placebo.

"The exact mechanism behind this effect is still not well understood, but Harris suggested that the anti-inflammatory activity of omega-3s might be contributing to this."

Read more: https://www.naturalnews.com/2019-03-28-omega-3s-reduced-risk-of-bleeding-in-surgery.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6302)


Curcumin stops cancer cell growth, NEW scientific discovery
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Date: April 27, 2019 10:10 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin stops cancer cell growth, NEW scientific discovery





Turmeric is hailed for its properties in helping to regulate blood sugar, fighting inflammation and infection, and helping cancer patients. In helping cancer patients, turmeric is able to affect cancerous cells without harming the non-cancerous cells. DYRK2 is inhibited by the turmeric, keeping the cancer from growing. Carfilzomib used with turmeric helped with cancer cell death with minimal affect to the healthy cells. Turmeric also promotes angiogenesis, which stops the growth of new blood vessels which support the growth of tumors, and also doesn't allow development of adhesion which leads to metastasizing of cancers.

Key Takeaways:

  • Turmeric was first cultivated in the SouthEast Asia and India. It is a kitchen spice that is revered for its ability to fight inflammation and regulate blood sugar.
  • New research shows that turmeric has even more potential. Due to its active compound, curcumin, research has shown that it could be used to fight cancer.
  • A new study conducted by researchers in United States and China showed that turmeric can successfully be used to target several aggressive forms of cancer.

"The team used cutting-edge X-ray crystallography to obtain 3D images – in which curcumin could distinctly be seen binding to the enzyme at the atomic level."

Read more: https://www.naturalhealth365.com/curcumin-cancer-cell-2659.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6206)


CBD Oil & Hemp Oil – Cannabidiol help your health and wellbeing
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Date: February 19, 2019 05:09 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: CBD Oil & Hemp Oil – Cannabidiol help your health and wellbeing





CBD Oil and Hemp Oil are much safer than alcohol and each of them bring a magnitude of health benefits to the user. When they're combined together, the effects are absolutely stunning. CBD and hemp oil can be the key to your good health and well-being. These properties, derived from the cannabinoid plant, can reduce pain, reduce anxiety and improve symptoms of depression, help glaucoma patients, and so much more. It is easy to say that this is a life changing health solution.

Key Takeaways:

  • A compound that can be extracted from the cannabis plant is CBD and CBD is used in medicine for several health issues.
  • CBD is not only used in healing several health issues but it is also used as a compound in creams and shampoos.
  • CBD oil is in high demand in the world today because it is used for curing depression and depression is affecting a lot of youths.

"The best part of using is that this compound is non – psychoactive, i.e., the intake of this compound will not affect any high sensations."

Read more: https://thefrisky.com/cbd-oil-hemp-oil-cannabidiol-help-your-health-and-wellbeing/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6043)


Curcumin Possesses ability to repair brain damage caused bystrokes
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Date: February 15, 2019 05:00 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin Possesses ability to repair brain damage caused bystrokes





Turmeric, a common spice, contains an active ingredient called curcumin. Recent findings are showing curcumin as being beneficial to patients with heart failure. Curcumin is believed to increase skeletal muscle strength, as well as increasing endurance capabilities to allow more exercise. Similar to ginger, another spice also shown to be beneficial, turmeric contains a high amount of antioxidants. Unfortunately, while curcumin is beneficial to heart failure patients, it simply is not a viable option due to the large amount of curcumin necessary to prove beneficial. That being said, turmeric, ginger, and many other high antioxidant substances are beneficial to humans, especially those with heart failure.

Key Takeaways:

  • Heart failure is life altering, because by weakening the heart and affecting its oxygen pumping ability, patients no longer have the ability to participate in activities they once enjoyed.
  • Despite being chronic and incurable, heart failure patients can, by using a change in lifestyle, decrease feelings of fatigue and enhance their mood so as to resume their lives.
  • The study that showed that curcumin from turmeric can help people with heart failure was done using mice although hopefully it can be done on humans.

"For those who appreciate the unique spiciness of turmeric, it’s serendipitous to learn there are several layers of extraordinary health benefits included with the active ingredient known as curcumin."

Read more: https://www.healthnutnews.com/curcumin-possesses-ability-to-repair-brain-damage-caused-by-strokes/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6033)


Homeopathy 101: How autoimmune disorders begin and how to treatthem holistically
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Date: February 01, 2019 11:10 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Homeopathy 101: How autoimmune disorders begin and how to treatthem holistically





Autoimmune disorders are caused when the immune system lacks on its main purpose and attacks itself. Many people struggle to find a way to get their immune systems. Studies have shown that homeopathy could shed some hope for people with immune disorders. When a homeopath looks at their patients, they want to know one's symptoms, pains, or sensations that they feel. They treat people as a whole, not one problem at a time, using this way of treatment is actually natural and less harmful than other options.

Key Takeaways:

  • The immune system is human's natural way of protecting itself against toxins and diseases.
  • Some people are more prone to getting sick because of the lifestyles that they live.
  • Homeopathy is about treating each person in a unique manner and not just focusing on the symptoms.

"Autoimmune disorders are prolific in today’s world, and many people who suffer from them are desperate for solutions that just can’t seem to be found."

Read more: https://www.naturalnews.com/2018-11-26-homeopathy-how-autoimmune-disorders-begin.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5997)


Diabetes: Cinnamon (Dalchini) May Help Control Blood Sugar Levels
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Date: January 30, 2019 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Diabetes: Cinnamon (Dalchini) May Help Control Blood Sugar Levels





For diabetic patients, food can often feel like the enemy. But what if spices are the answer? Cinnamon has been shown to reduce blood sugar levels in patients that have type 2 diabetes from a fasting state as well as to possess anti oxidant traits. For the American diet, most people associate cinnamon with sweets, thus helping to reduce cravings for those food items from a psychological standpoint. And best of all, it only takes around five grams to also aid in digestive health, which is also important to stabilizing blood sugars.

Key Takeaways:

  • Cinnamon is a very common spice in Hindu culture and known to help manage many different health issues.
  • It is full of antioxidants that reduce oxidative tension and known to manage diabetes.
  • If taken on a regular basis, it will reduce blood sugar levels in fasting people and reduce cholesterol levels.

"Various studies talk about cinnamon as a wonder spice that keeps a check on our blood sugar levels, especially when consumed after meals."

Read more: https://www.ndtv.com/food/diabetes-cinnamon-dalchini-may-help-control-blood-sugar-levels-1961593

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5993)


Boswellia extract exhibits profound healing and anti-inflammatory properties
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Date: January 19, 2019 10:08 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Boswellia extract exhibits profound healing and anti-inflammatory properties

Originating in the mountain ranges of India and Northern Africa, the boswellia tree produces a gum resin that has shown to be revolutionary for cancer patients, as well as those facing chronic inflammatory conditions. In 2003, a study was conducted that showed just how effective boswellia extract can be in treating osteoarthritis by significantly reducing levels of pain and swelling. It has also been shown to help treat conditions such as inflammatory bowel disease (IBD) and inflammatory conditions of the colon.

Key Takeaways:

  • Arthritis, which affects the musculoskeletal system, is characterized by intense stiffness, inflamed joints and painful knots.
  • Although not lethal, arthritis can be extremely debilitating, as it can interfere greatly with a sufferer's ability to perform normal tasks of daily living.
  • Besides alleviating the effects of arthritis, the herb, Boswellia, can aid in counteracting the effects of bursitis, tendonitis, osteoarthritis, autoimmune conditions and headaches.

"Thankfully, several studies have determined that a powerful herb with anti-inflammatory effects can help relieve arthritis."

Read more: https://www.naturalnews.com/2019-01-14-boswellia-extract-has-healing-and-anti-inflammatory-properties.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5975)


Almonds are good for your heart, brain, AND stomach
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Date: November 21, 2018 03:35 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Almonds are good for your heart, brain, AND stomach





Almonds are an extremely versatile food. They can be added to just about any food. It also provides great benefits for your heart, stomach, and brain. Almonds can decrease one's heart attack risks. It can also regulate one's blood sugar and improve memory. In addition, ingesting almonds long term can aid healthy gut microbiota and it can help prevent cancer. They can also help a person keep a healthy weight, and almonds can even extend a person's life.

Key Takeaways:

  • Almonds are beneficial to the heart since they are rich in polyphenols and vitamin E that work as antioxidants and prevent free radicals from accumulating.
  • Insulin resistance, especially in Type 2 diabetes patients, has been associated with magnesium deficiency
  • Eating almonds can promote better memory by increasing the production of the neurotransmitter acetylcholine in the brain.

"Eating almonds is beneficial for heart, brain, and stomach health and function."

Read more: https://www.naturalnews.com/2018-10-30-almonds-are-good-for-your-heart-brain-and-stomach.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5850)


Some Using CBD Oil to Help Pets Reduce Stress, Anxiety
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Date: July 09, 2018 05:54 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Some Using CBD Oil to Help Pets Reduce Stress, Anxiety





Some Using CBD Oil to Help Pets Reduce Stress, Anxiety

Some Buffalo City pet owners are starting to use CBD oil to help their furry friends with pain and anxiety. Products such as Complete Body Daily’s CBD-infused dog treats, which contain 2 milligrams of CBD, can help dogs and cats with joint and back pain, separation anxiety and other issues. CBD has similar effects on canine and feline nervous systems as in humans, and two or three a day will work for most breeds, depending on size and metabolism.

Key Takeaways:

  • A Buffalo city alderman chose to shut down one CBD boutique before it could even open up to the public.
  • One Ozark pet parent found that CBD oil helped her aging Dachshund with it's aches and pains.
  • Other pet parents have found that the oil is useful for pets experiencing separation anxiety.

"But in some parts of the region, like Arkansas, CBD oil is being used for an array of treatments and patients, including pets."

Read more: https://www.ozarksfirst.com/news/some-using-cbd-oil-to-help-pets-reduce-stress-anxiety/1284875152

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5662)


A natural sugar molecule, D-ribose, found to improve heart function and blood flow
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Date: July 04, 2018 09:54 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A natural sugar molecule, D-ribose, found to improve heart function and blood flow





A natural sugar molecule, D-ribose, found to improve heart function and blood flow

D-Ribose is a simple sugar molecule that plays an important role in energy metabolism within your body by helping to produce cellular energy in the form of adenosine triphosphate (ATP). Oxidative stress can deplete ATP, which can then cause further stress, in a vicious cycle for your heart. However, D-Ribose supplements can restore levels of ATP, which can improve heart function and exercise endurance in cardiac patients. Infusion of D-Ribose after a cardiac event may even be able to prevent dangerous ischemia reperfusion injuries.

Key Takeaways:

  • D-Ribose is a sugar molecule that plays a key role in producing cellular energy in the form of adenosine triphosphate (ATP).
  • Supplementary D-Ribose can replenish depleted ATP in cardiac patients, improving heart function and exercise endurance.
  • Injections of D-Ribose can help to limit ischemic reperfusion injuries that can occur in the wake of a heart attack or stroke.

"With one occurring every 40 seconds in America, you likely know more than a few people who have experienced one."

Read more: https://www.naturalnews.com/2018-07-01-natural-sugar-molecule-d-ribose-improve-heart-function-and-blood-flow.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5654)


What You Should Know About CBD Oil
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Date: May 25, 2018 07:16 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: What You Should Know About CBD Oil





What You Should Know About CBD Oil

All marijuana strands have two components within them: THC and CBD. THC is the component that has psychoactive effects on those who consume it, but CBD carries the benefits of marijuana without those psychoactive side effects. It has been shown to work well in epileptic patients, along with those who suffer from a long list of other medical ailments. Unfortunately, the tests done to prove these claims were all pre-clinical, which means they were not tested on humans instead of mice and test tubes.

Key Takeaways:

  • All strands of cannabis include over 100 forms of cannabinoids, many of which we have not studied as much as THC.
  • There are over 23,000 scientific papers that support research showing how CBD oil helps medical conditions.
  • CBD oil can also cause changes in appetite, and some other troublesome symptoms such as diarrhea.

"THC can affect the CB1 receptors, and it’s responsible for weed’s high. CBD is a little more complicated; it can affect both types of receptors, but often in indirect ways. The exact mechanisms aren’t fully understood."

Read more: https://vitals.lifehacker.com/what-you-should-know-about-cbd-oil-1825430458

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5607)


4 Groundbreaking Studies on Cannabis and Disease
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Date: November 17, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 4 Groundbreaking Studies on Cannabis and Disease





Cannabis is becoming more popular for the treatment of many diseases and ailments. It is becoming legal in more places as well due to studies which show its effectiveness. This talks about four such studies. If you are leery of cannabis this might ease your mind. It is often helpful. Many people swear by it as a treatment. It also doesn't tend to have many negative side effects the way medications can. It is safer.

Key Takeaways:

  • Presently, 29 states and the District of Columbia have regulations in place that allow physicians to recommend medical cannabis to patients, however, dosage and treatment information is lacking.
  • There are currently four medical cannabis clinical trials happening in North America, which are assessing the benefits of medical cannabis on Alzheimer’s, Parkinson’s, PTSD, and brain tumors.
  • Hopefully, these new studies will help researchers and physicians determine exact doseages and treatment applications for specific ailments.

"This study will allow researchers to better understand the potential risks and benefits of cannabis use among veterans with PTSD and aid in cannabis-based decision making among patients and their physicians."

Read more: http://www.care2.com/greenliving/4-groundbreaking-studies-on-cannabis-and-disease.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5401)


Wheat Germ Oil and Fish Oil Combination Benefits In Hemodialysis Patients
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Date: September 08, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Wheat Germ Oil and Fish Oil Combination Benefits In Hemodialysis Patients





A recent study has shown that giving fish oil and wheat germ oil to hemodialysis patient maintains healthy blood calcium levels. The study used a placebo control group and it was a double blind study. This is a positive finding for those concerned about mineral bonus when they are on hemodialysis. The study however was also hoping to find that these omega fatty acid supplements would also affect other minerals as well as information in the system of these patients. They did not receive the results they were looking for and further research may be necessary.

Key Takeaways:

  • Chronic kidney disease, which can lead to end-stage renal disease, generally leaves the patient with the options of only hemodialysis or transplantation.
  • Pathological changes in renal tissue start with oxidative stress and inflammatory reactions as well as changes in the metabolism of several substances, including calcium.
  • A combination of two nutritive oils, specifically wheat germ and fish, could have beneficial effects on serum calcium levels in ESRD patients, thereby helping those on hemodialysis.

"A recent randomized, placebo-controlled trial published in International Urology and Nephrology, examined the impact of combined supplementation of fish oil (FO) with wheat germ oil (WGO) on mineral-bone and inflammatory markers in HD patients."

Read more: https://www.medicalnewsbulletin.com/wheat-germ-oil-fish-oil-hemodialysis-patients/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5235)


Fish Oil Supplements: Are They Good for Cardiovascular Health?
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Date: March 23, 2017 08:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Fish Oil Supplements: Are They Good for Cardiovascular Health?





Conventional wisdom has long been that fish oil supplements are very beneficial for heart health. In fact, the American Heart Association (AHA) recommends fish oil for heart patients. However, there is some disagreement about the effectiveness and safety of fish oil. Read this article and discover 3 reasons why some data may be flawed regarding this supplement along with concerns regarding safety of some fish oil. In the end, eating fish may be more heart-healthy.

Key Takeaways:

  • While the American Heart Association recommends heart patients consume fish oil tablets, one MD is not so sure.
  • While some studies seem to show that Omega 3 fatty acids from fish oil are good for heart patients, some doctors see flaws in the structure of the studies.
  • Since the FDA does not regulate fish oil pills, one doctor suggests it could be more beneficial to just eat more fish.

"Fish oil contains omega-3 fatty acids, which, when consumed by eating fatty fish, can cause blood vessel relaxation, reduced blood clotting, reduced inflammation and possibly stabilization of heart rhythm."

Read more: https://health.clevelandclinic.org/2017/03/fish-oil-supplements-good-cardiovascular-health/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4266)


Garlic helps lower cholesterol in diabetes patients
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Date: March 20, 2017 08:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Garlic helps lower cholesterol in diabetes patients





A study recently published in the Pakistan Heart Journal would seem to indicate that eating garlic lowers cholesterol in diabetes patients. The study involved a sample group of thirty patients, with ages ranging from thirty to sixty years old. The patients were administered a dose of three hundred milligrams of a local garlic product for eight weeks, and showed improved rates of cholesterol. It is noted that statins are good for lowering cholesterol, but readers uncomfortable with statins might want to consider red rice yeast, which has also demonstrated effectiveness in lowering cholesterol.

Key Takeaways:

  • Researchers recently studied the affect of adding an intake of 300 mg of garlic, to the diet of patients with diabetic dyslipidimia.
  • Researchers noted an overall drop in cholesterol, with an uptick in good cholesterol.
  • Because Statins, which are a good pharmaceutical option for many high cholesterol sufferers, have negative affects for some, research showing natural substitutes is encouraging.

"A report published in 2017 in Pakistan Heart Journal suggests that eating garlic can help improve the cholesterol status in patients with type 2 diabetes mellitus."

Read more: http://www.foodconsumer.org/newsite/Nutrition/Food/garlic_helps_lower_cholesterol_in_diabetes_patients_0316170206.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4232)


Cannabidiol (CBD) Inhibits Cancer Growth According to Medical Researchers, Announces Phillip Fry
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Date: March 12, 2017 04:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Cannabidiol (CBD) Inhibits Cancer Growth According to Medical Researchers, Announces Phillip Fry





More and more, the non-psychoactive marijuana extract called Cannabidiol or CBD is becoming an alternative treatment. Research has existed that pointed to CBD's uses for treating nausea in chemotherapy patients, fighting neurodegenerative diseases and seizures in patients, but the most recent findings could indicate that CBD is more useful than ever imagined. Recent studies have concluded that CBD, which is an extract that doesn't have the psychoactive aspects marijuana is known for, shows significant signs of fighting cancers cells for a number of different types of cancer. The scientific community is publishing a record number of research, much of it pointing to the marijuana extract, CBD, having unknown but possibly lifesaving potential.

Key Takeaways:

  • Non psychoactive cannabis can have an effect of fighting aggressive cancers.
  • CBD has been shown to inhibit cancers in the colon,breast, and prostate
  • The National Cancer Institute recognizers cannabis as a treatment for providing relief

"Chemical components of Cannabis, called cannabinoids, activate specific receptors throughout the body to produce pharmaacologic effects"

Read more: http://www.digitaljournal.com/pr/3259779

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4111)


Vitamin C is a powerful heart healer, especially after surgery
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Date: February 13, 2017 01:19 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Vitamin C is a powerful heart healer, especially after surgery





Vitamin C has long been known to have healing properties. It boosts the immune system. We are told to use it when we're having a cold or other illness. It is apparently also good for healing the heart. Surgery can be hard on the heart and vitamin C is helpful at this time.

Key Takeaways:

  • Vitamin C can greatly reduce AF after surgery
  • Vitamin C had no side affects versus prescription drugs that do
  • Vitamin C works best in countries that are poor and where the people have not had long term exposure to the vitamin

"A new study, published in the journal BMC Cardiovascular Disorders, found that oral administration of supplemental vitamin C after heart surgery could slash the risk of AF by up to 73 percent in high-risk patients, without adding side effects."



Reference:

//www.naturalnews.com/2017-02-10-vitamin-c-is-a-powerful-heart-healer-especially-after-surgery.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3934)


'Red Yeast Rice' Statin Alternative Not Harmless Either, Study Says
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Date: February 02, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 'Red Yeast Rice' Statin Alternative Not Harmless Either, Study Says





If you suffer from high cholesterol, you are probably being prescribed a statin. Along with the effectiveness of statins to treat cholesterol issues, there is also the risk of side effects such as muscle and liver damage. For a while, red yeast rice has been recommended as a natural alternativeto prescribed statins. However, it has recently been found that this alternative choice can also increase muscle and liver injury. This is believed to be due to the fact that the active ingredient in each is monacolin K.

Key Takeaways:

  • Red yeast rice could increase risk of muscle injury or liver damage, Italian researchers reported after reviewing 13 years of patient data.
  • the compounds in red yeast rice -- monacolin K -- has the same chemical structure as the statin drug lovastatin [...] and cannot be sold legally as dietary supplements.
  • Reports of muscle pain came from 19 patients, including some who experienced an increase in levels of creatine phosphokinase [...] The products are not as well-controlled and the dosages are variable

"Red yeast rice could increase risk of muscle injury or liver damage."



Reference:

//www.medicinenet.com/script/main/art.asp?articlekey=201194

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Which Vitamins are Good for Dry Eyes?
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Date: January 28, 2017 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Which Vitamins are Good for Dry Eyes?





If you suffer from dry eyes, you know how annoying and painful it can be. There are many medications out there that cater to this all too common condition, but what if your diet can help with the problem? While vitamins A, C, E, and zinc are all good for eye health, there is currently debate on whether or not vitamins can help with dry eyes. Vitamin A, vitamin D, and omega-3 have been linked with dry eyes in patients, but more research needs to be done to see if increasing doses will help with symptoms.

Key Takeaways:

  • Dry eye syndrome is a common condition that occurs when the eyes do not make enough tears, or if the tears vanish too quickly.
  • If an individual has a healthy balanced diet, they should be able to get all the vitamins and minerals they need from their diet. However, some people may need to take a supplement if advised by their doctor.
  • In these cases, dietary antioxidant vitamins A, C, and E, and the mineral zinc may help prevent conditions such as age-related macular degeneration (AMD) from developing. AMD is a condition where vision is lost in the macular, which is the part of the eye that controls central vision.

"Dry eye syndrome is a common condition that occurs when the eyes do not make enough tears, or if the tears vanish too quickly. There are many treatments for dry eyes. Can vitamins help prevent or treat dry eyes? We find out. If an individual has a healthy balanced diet, they should be able to get all the vitamins and minerals they need from their diet. However, some people may need to take a supplement if advised by their doctor."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.trailblazersng.com/vitamins-good-dry-eyes/&ct=ga&cd=CAIyGmY4MTYyZmQ1NTMyNTY3NGQ6Y29tOmVuOlVT&usg=AFQjCNGavfZvvHoHaoEjEF_rV5L2dRZe2g

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Natural Allopathic medicine: the power to heal and cure cancer
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Date: January 04, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Natural Allopathic medicine: the power to heal and cure cancer





With health care costs and the price of prescription drug costs on the rise many people are looking for alternative treatments, including natural remedies. While big pharmaceutical companies try to discount the benefits of natural remedies, proponents provide interesting information about the benefits. Check out the article for some recent news regarding natural approaches to medicine

Key Takeaways:

  • Good medicine should strive vigorously to do no harm to patients, while providing the knowledge and pathways for individuals to heal themselves.
  • Healthcare should empower patients with strong mindset, not fear of disease. The system should work to prevent health problems instead of trying to capitalize on managing and creating new problems.
  • Today’s allopathic system oftentimes seems like a cult, heavily influenced by pharmaceutical companies. Allegiant to synthetic drugs and standard procedures, MD’s often shun anything that’s natural.

"Today’s allopathic system oftentimes seems like a cult, heavily influenced by pharmaceutical companies."



Reference:

//www.naturalnews.com/2016-12-21-natural-allopathic-medicine-the-power-to-heal-and-cure-cancer.html

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Tired? Weak? You're not 'just getting old'; something is wrong
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Date: December 27, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Tired? Weak? You're not 'just getting old'; something is wrong





When we start feeling rundown and tired, we tend to make jokes about getting old. The truth is, however, that feelings of depression and fatigue are not normal aging side effects. If these feelings are longer than expected, a consultation with a doctor is in order. You know your body best. If something doesn’t feel right, don’t try to pass it off as aging. There are many factors, medical and physical, that can cause signs of fatigue, depression, change of appetite, and weakness. Only a doctor can order the tests that can tell you the exact reason, so don’t hesitate.

Key Takeaways:

  • When Dr. Christopher Callahan examines older patients, he often hears a similar refrain.
  • This fatalistic stance relies on widely-held but mistaken assumptions about what constitutes normal aging
  • Instead, they're a signal that something is wrong and a medical evaluation is in order.

"If you suddenly find your thinking is cloudy and your memory unreliable, if you're overcome by dizziness and your balance is out of whack, if you find yourself tossing and turning at night and running urgently to the bathroom, don't chalk it up to normal aging."



Reference:

//www.cnn.com/2016/12/16/health/fatigue-weakness-depression-aging/index.html

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Most Americans Have Inadequate Intakes of Vitamins and Minerals: Can Supplements Help?
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Date: December 22, 2016 06:39 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Most Americans Have Inadequate Intakes of Vitamins and Minerals: Can Supplements Help?





It is estimated that 90% of humans are deficient in one or more essential vitamins and minerals. While some may be due to inadequate absorption, most is believed to be due to poor nutrient intake. Vitamin B12 and vitamin D have been identified as two of the worst deficiencies. Although nutrient needs should be met primarily by diet, there are supplements available if the diet doesn’t allow for a proper balance. A multivitamin may be recommended for most people who are at risk of a deficiency.

Key Takeaways:

  • Evidence clearly shows that many Americans obtain less than the required amounts of a number of vitamins and minerals, and that dietary supplement use increases intakes and reduces rates of nutritional inadequacies.
  • When counseling patients, health professionals should emphasize the value of obtaining nutrients from a balanced diet.
  • They found that more frequent use of MVMS was associated with higher rates of nutrient adequacy than low frequency of use or no use (Figure).

"Evidence clearly shows that many Americans obtain less than the required amounts of a number of vitamins and minerals, and that dietary supplement use increases intakes and reduces rates of nutritional inadequacies."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//medcitynews.com/2016/12/americans-inadequate-intakes-vitamins-minerals-can-supplements-help/&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNEEfevLKIuJWu3I8RkuRI5IKijEFA

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High-dose vitamin C reduces inflammation in cancer patients, study shows
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Date: December 07, 2016 04:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: High-dose vitamin C reduces inflammation in cancer patients, study shows





It is was the first time this type of treatment was tested and studied specifically for its effects on inflammation in cancer patients. The results found indicate great promise for the use of high-dose intravenous vitamin C treatments to help reduce inflammation in cancer patients, which is one of the major factors of cancer and its progression. A range of cancers has been proven to benefit from vitamin C treatments, including cancers of the prostate, breast, skin, bladder, lung, pancreas, thyroid, and B-cell lymphoma.

Key Takeaways:

  • Now, another study is confirming its effectiveness against inflammation in cancer patients, one of the primary markers.
  • High levels of inflammation seem to indicate a higher risk of cancer as well as a less hopeful prognosis for healing and recovery.
  • The current amount of inflammation in the body can actually predict the chances and length of survival time for numerous types of cancer.

"High levels of inflammation seem to indicate a higher risk of cancer as well as a less hopeful prognosis for healing and recovery."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//beforeitsnews.com/health/2016/11/high-dose-vitamin-c-reduces-inflammation-in-cancer-patients-study-shows-2685671.html&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNG6cmuxsW-aHmxvEVt_iv91-ZQBYw

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Insights on the link between kidney damage and cognitive impairment
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Date: December 04, 2016 08:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Insights on the link between kidney damage and cognitive impairment





A recent study has found that patients with kidney disease are at a higher risk of having impaired cognitive function. The reason for the connection is unknown. The main indicators of cognitive impairment were increased albuminuria and lowered glomerular filtration rate. When these values got worse in patients, their brain function was found to be more impaired.

Key Takeaways:

  • People with kidney disease are at high risk of cognitive impairment, but the nature of this relationship remains uncertain.
  • After adjusting for various demographic and clinical characteristics, higher albumin in the urine, which is indicative of poor kidney function, was linked with worse performance on tests of global cognitive function, executive function, memory, and attention.
  • Lower estimated glomerular filtration rate, another indicator of poor kidney function, was linked with worse performance on tests of global cognitive function and memory.

"The findings cement the association between kidney damage and cognitive functioning, suggesting that albumin in the urine and changes in brain structure are likely both representations of the same vascular process, just in different organs,"



Reference:

https://www.sciencedaily.com/releases/2016/11/161117204911.htm

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Reducing salt intake may help protect kidney patients’ heart and kidney health
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Date: December 03, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Reducing salt intake may help protect kidney patients’ heart and kidney health





Chronic kidney disease is a serious condition. One of the most detrimental effects of the disease is albuminuria. In most patients, this effect can be controlled by kidney medications. In some, however, albuminuria cannot be reduced. A recent study in which 45 patients were asked to reduce their sodium intake, take paricalcitrol, or both showed promising results in significantly reducing albuminuria. Reducing salt intake alone helped, but combining both salt reduction and paricalcitrol provided the best results.

Key Takeaways:

  • New research indicates that reducing sodium intake may provide kidney and heart benefits for patients with chronic kidney disease.
  • Investigators found that dietary sodium restriction led to a significant reduction of residual albuminuria and blood pressure.
  • Even a moderate reduction in sodium intake may provide serious health benefits.

"The investigators found that dietary sodium restriction led to a significant reduction of residual albuminuria and blood pressure, whereas paricalcitol had no significant effect on these measures. The combination of paricalcitol and a low sodium diet, however, resulted in the lowest albuminuria levels."



Reference:

https://www.sciencedaily.com/releases/2016/11/161117204914.htm

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Vitamin D levels tied to breast cancer survival
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Date: November 21, 2016 02:47 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Vitamin D levels tied to breast cancer survival





We’ve all heard that we should be getting plenty of vitamin D in our diet. Now there may be an even better reason to keep our vitamin D levels up. A recent study has shown a link between high levels of the vitamin and a better prognosis for breast cancer. They claim that boosting levels during treatment didn’t change the outcomes. Patients who had high levels at the time of diagnosis had the best results in the end. They were less likely to die of any cause from the cancer. It is recommended that adults get 600-800 IU of vitamin D each day.

Key Takeaways:

  • Higher levels of vitamin D may be tied to better odds of surviving breast cancer.
  • In a recent study of breast cancer patients, roughly 100 women with the lowest vitamin D levels died, compared to only 76 women with the highest levels of vitamin D.
  • A randomized control trial is necessary to determine whether there is a direct, causal link.

"For women diagnosed with breast cancer, high vitamin D levels in the blood may be tied to better odds of surviving and having tumors with less deadly characteristics, suggests a new study."



Reference:

//www.reuters.com/article/us-health-vitamind-breast-cancer-idUSKBN13625E?feedType=RSS&feedName=healthNews&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+reuters%2FhealthNews+%28Reuters+Health+News%29

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Is Coconut Oil A Brain Food?
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Date: January 26, 2014 09:34 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Coconut Oil A Brain Food?

It is amazing how coconut oil has been ascribed as a good brain food.

coconut treeSince Dr. Mary Newport associated coconut oil with the ability to cure Alzheimer’s disease, it has attracted the attention of researchers and other interested parties. However, her attractive explanation of how the oil helped her husband to improve her husband’s Alzheimer’s disease can be described from the observation of an Alzheimer patient’s brain.

Taking into consideration Axona that is usually used by Alzheimer’s patients, its active ingredients is the caprylic acid that is extracted from the oil. As a substitute, Dr. Newport used coconut food products such as oil and milk in her husband diet to achieve the same quantity of MCTs. This improved her husband’s condition a clear indication that coconut oil has some medicinal value. From a scientific point of view, it is approved that the disease is caused by insulin resistant cells thus causing the brain to unsuccessfully use glucose to fuel their activity. In its place, ketone bodies are used as a substitute fuel supply. Coconut oil is a good supply of medium-chain triglycerides (MCTs), for instance caprylic acid that is simply transformed into ketone bodies in the liver when ingested. Then they act as an alternative of glucose which provides fuel for the brain. Neuroprotective effect of the coconut oil is attributed to the ketone bodies formed as a byproduct of coconut oil metabolism. Therefore, leading to an energy metabolism. The ketone bodies will then supply the compromised brain structure with the much-needed alternative fuel source from the Ketone bodies.

However, it is of the essence to state that coconut oil is only known for improving the condition. For this reason, there has been an increased call for more research, particularly human clinical trials. Since there is no any cure yet, coconut oil is going to remain a good brain food of choice for others who are experiencing Alzheimer.

References:

  1. //www.greenmedinfo.com
  2. //www.naturalnew.com/030373_cocnut_oil_alzheimers_disease.html
  3. //www.naturalnews.com/028753_alzheimers_drugs_trials.html


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What Makes St Johns Wort Good For Depression And Anxiety?
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Date: September 18, 2012 09:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Makes St Johns Wort Good For Depression And Anxiety?

St Johns wort

St Johns wort is a particular plant species. Firstly, in ancient Greek the medicinal uses of St Johns wort are recognized. It is an herb with yellow flowers. It contains active ingredients like flavonoids, anthrancenes, volatile oil and sugar alcohol which are used for medicinal purpose. St Johns wort binomial name Hypericum perforatum is also considered as wild plant, herb and weed. The other common names for this plant are Amber Touch-and-heel, goat weed, Klamath weed, Rosin rose and Tipton weed. As it is an herb its leaves and flowers are used for medicinal purpose.

What is St Johns wort?

St Johns wort is considered as a medicinal plant. It has yellow flowers which are used for medical purposes in various parts of the world. It is an herbal remedy to treat depression. This medicinal plant is also used for migraine, headache, muscle pain, chronic fatigue syndrome. It is also used for cancer and HIV/AIDS. St Johns is known as natural herbal remedy for mild to moderate depression. This highly valuable contains a chemical known as hypericin which effects against depression. This chemical act as mediatator in the nervous system which control the mood.

Does St Johns worth help depression? Depression has now become a common problem in humans now days. Due to the side effects of antidepressant medications, people are frequently moving towards natural remedies. St John wort is a complete health booster for the entire nervous system. It is recommended as a useful herbal remedy. It is scientifically proven that this particular plant is effective for mild to moderate depression. It has been used to treat mental disorders. St John wort is commonly used for depression and the conditions which are responsible depression such as anxiety, tiredness and sleep disorders. In most of the countries it is widely prescribed for depression. Wort is beneficial to people with mild depression but it is less effective on major depression.

St Johns wort medicinal properties:This medicinal plant is a powerful medicine.It is effective and well tolerated by the patients.You can feel yourself improving within the first week of usage of St John wort.As it is well tolerated by the patients, you can see fast results with fewer side effects.It decreases anxiety related to depression.It includes medicinal properties like antibacterial, anti inflammatory, antiviral, antidepressant and pain relieving.Traditionally it has been used to cure burns, headache, wounds, etc.

Though this is a powerful and remarkable medicine for treating mild to moderate depression, but still there is a question in the mind of health experts regarding major depression? In accordance with this, medicinal wort is less effective for the people who are taking other medications. St John wort is not effective on severe depression as discussed earlier. St John wort causes drug interaction so it might not be the right choice for the people who take other medication. You cannot ignore St Johns Wort, as it is a natural remedy for treatment of depression in spite of having few side effects.

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What Makes Curamed such a good Pain Remedy?
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Date: October 24, 2011 08:24 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Makes Curamed such a good Pain Remedy?

Curamed And Pain (Inflammation)

Curamed is an herbal supplement primarily used as a pain relief treatment. This product is a combination of many herbs which has anti - inflammatory properties. In addition, this supplement which is a blend of many herbs is also useful in enhancing the defense mechanism of the body against harmful microorganisms and illnesses. And not to mention, Curamed also contains powerful antioxidants to help protect the body from free radical damage.

Many users have reported that Curamed is effective as a pain remedy. Clinically, Curamed is approximately equal to 4,000 milligrams of curcumin and 85,000 milligrams of turmeric. Turmeric is a pepper - like herb which has a bitter taste but mild aroma. This herb is commonly used since the ancient times as a home remedy for pain. The mechanism of action of this herb is said to be because of its ability to reduce inflammation thus reducing swelling and pain sensation. Clinical studies showed that the substance in turmeric is called curcumin. This is the chemical substance in the herb which has a strong anti – inflammatory property. It can even relieve swelling and pain during osteoarthritis and rheumatoid arthritis attacks. The anti –inflammatory effect of curcumin has been compared to that of the common and effective anti -inflammatory drugs such as hydrocortisone and phenylbutazone. The good thing is that though they may have similar actions, curcumin does not have the toxic effects associated with those drugs such as ulcer formation, leucopenia and intestinal bleeding.

Curamed supplement contains proprietary complex which can provide an enhanced bioavailability and constant retention time inside the body. It is formulated using a distinctive and patented process so that it can deliver the anti – inflammatory ingredient curcumin to the body 1000%. The patented process also allows the chemicals to be inside the body for about 8 to 12 hours. Curamed is clinically studied and proven with the help of intensive research. In addition, Curamed has also been found to be an effective liver detoxifier and protectant.

Other ingredients containing the Curamed supplement include triglycerides, glycerin phosphatidylcholine lecithin, purified water and beeswax. It contains only natural ingredients and has no sugar therefore it is safe for diabetic patients and those who are under weight loss programs. It also contains no salt and gluten making it safe for cardiovascular disease and Celiac disease patients, respectively. Each product container contains 30, 60 or 120 750 milligram – soft gel. It is made available in health food stores, drug stores and even Online. Make sure to check labels before purchasing since there are many imitations and fraud.

Recommended dosage depends on the individual’s age, gender, pain threshold, health condition and other related factors. The recommended dosage is usually one to two soft gels everyday. Give Curamed a try and feel the difference!

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Herbs For Depression
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Date: December 13, 2010 12:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Herbs For Depression

Fight Depression with Natural Herbs

depression getting you down

Before discussing treating depression with natural herbs we should first consider depression itself: what is it and what causes people to become depressed? Psychiatrists and psychologists will suggest a number of definitions although most experts agree that there are two forms of depression.

Causes of Depression

Exogenous depression comes about as a result of external factors such as bereavement, heavy debt, job loss, etc, while endogenous depression comes from within and is believed to be due to biochemical problems, including food allergies, hormonal changes, thyroid problems, nutritional deficiencies, particularly Vitamin B deficiency, and addictions. There are many other reasons for people becoming depressed, some of which can be established by the particular symptoms of the individual.

In many cases of depression the external factors are often easier to treat than those due to internal factors. Many exogenous causes of depression such as bereavement are alleviated through time, while causes such as job loss and debt can be resolved once the cause has been rectified: thus, if the patient is no longer in debt or is re-employed, the depression tends to disappear with the cause.

Symptoms of Depression

Depression is not diagnosed from a single symptom, but from a number of symptoms that can point to a person being clinically depressed and requiring treatment. Among the symptoms of depression are:

Prolonged periods of sadness or despair
Feelings of pessimism for the future
Feeling generally tired and lethargic
Overeating with resultant weight gain or under-eating with resultant weight loss
Either insomnia or hypersomnia
Disinterest in family or work
Feeling of guilt, worthlessness and low self-esteem
Inability to concentrate
Hyperactivity or general inactivity
Suicidal thoughts

Forms of Depression

Many normal people can suffer one or two of the above systems, and would not be diagnosed as depressed because of it. We can all get mood swings, feel a bit worthless now and again or be unable to concentrate or focus at times, but that does not mean we are clinically depressed.

Depression would not be diagnosed in a patient with just one of these symptoms but five or more likely would be. In fact, the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders deem the patient suffering clinical depression if displaying 5 or more of the bottom 8 symptoms above for a month or more. This is believed to be the case with around 17 million Americans so it is a significant problem.

Manic depression is otherwise known as bipolar disorder, where patients have large mood swings from high and extreme hyperactivity and excitability to very low deeply depressive moods and is a clinical condition generally treated using drugs.

Treatment of Depression With Natural Herbs

The usual treatments are drugs that often have undesirable side effects; so many people are trying natural remedies instead. There are a number of herbs that can be used to treat depression, one of the most familiar being St. John's Wort. However, there are others, and here is a synopsis of each.

St. John's Wort

st johns wort picsSt. John's wort (hypericum perforatum) is likely the best known herbal treatment for depression. In fact, in Germany it is prescribed by doctors to children and adolescents for the treatment of mild depression and is available over the counter in many countries.

However, it can also be used in cases of severe depression, and a report in the Cochrane Database Review[8(4)] by K. Linde, M.M. Berner and L. Kriston in 2008 stated that of 29 separate tests carried out on a total of over 5,000 patients, the conclusion was that St. John's wort extracts were at least as good in treating severe depression with 5 times lower side-effects as tricyclic antidepressants and twice lower than the new selective serotonin reuptake inhibitors (SSRI).

It should be stated, however, that one trial on 340 subjects indicated no improvement over a placebo. However, the anti-depressive drug sertraline (Zoloft) was also shown to be no better than the placebo in this test, so some doubts must lie regarding its accuracy. Of all the herbal treatments, St. John's wort has had most testing carried out and it seems to be effective in treating mild to severe depression although not all experts are yet agreed.

Kava Kava Root

kava kava root picsKava kava can be used to treat depression and anxiety, largely due its content of kavalactones that are believed to increase the amount of a number of neurotransmitters in the blood, including the feel-good neurotransmitter serotonin. Kava kava root is mildly intoxicating, having much the same effect as alcohol, and can also reduce the symptoms of depression and anxiety.

However, it is doubtful if its effects are permanent and so it may be less of a depression cure as a short-medium term treatment. Its effects are also variable on different people, some describing it as making them feel relaxed and 'dreamy', while others find it therapeutic and making them feel better in themselves.

Kava kava should not be taken without your doctor knowing about because there have been concerns about its effect on the liver if taken in excess. A European-wide ban was lifted about two years ago after testing found the risks of taking it to be very low. It has been used for centuries as an intoxicating drink on islands such as Fiji.




Passion Flower

passion flower picsPassion flower has been used for centuries to treat anxiety, stress and depression, its active ingredients believed to be maltol and ethylmaltol that help to increase the level of gamma-aminobutyric acid (GABA) in the brain. GABA is one of the brain's key neurotransmitters and has been described by some as the brain's own 'Valium' supply.

Through the intervention of GABA, passion flower extract helps in reducing anxiety levels and makes you feel a lot calmer. If you suffer forms of depression that make you hyper or excitable, passion flower will help to reduce this and also helps to cure insomnia. It is a component of many natural sleeping pills.

These are just three natural substances that can be used to treat depression. However, you must inform your doctor or physician if you decide to take them since they may interfere with or change the effect of any antidepressant drug you are currently taking.

Call today for natural remedies for depression

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Garcinia, Hydroxycitric acid and weight loss
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Date: December 03, 2009 01:10 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garcinia, Hydroxycitric acid and weight loss

Garcinia is part of the plant genus in the family Clusiaceae. This plant is native to Asia, Austrlia, tropical and southern Africa, and Polynesia. The number of species of the garcinia plant is highly disputed, but various sources recognize between fifty and three hundred species that are specifically valid. The plants in this genus are commonly called saptrees, mangosteens, or monkey fruit.

Garcinia is a little-known fruit that can be found growing extensively in India and Thailand. Used for centuries as a condiment, garcinia is also known as Malabar tamarind or Gorkapuli. The garcinia fruit is about the size of an orange and orange in color. However, it looks similar to an acorn squash in appearance. With approximately two hundred different species of garcinia, only few contain the needed component necessary for herbal health. Scientists have identified the natural compound found in garcinia to be hydroxycitric acid, which can help to curb appetite, reduce food intake, and slow the body’s fat production.

Hydroxycitric acid, that active component in garcinia, is similar to the citric acid that is found in citrus fruits like oranges, lemons, and grapefruit. The garcinia fruit is actually composed of about fifty percent hydroxycitric acid. This acid seems to have potent fat-fighting properties and is known for its ability to block the formation of fatty tissue, which results in less storage of fat. The rind of the garcinia fruit contains high amounts of hydroxycitric acid, which inhibits citrate lyase, which is an enzyme require to manufacture body fat. The hydroxycitric acid combines with citrate lyase, which leaves less of the enzyme available to form body fat and speeds up the fat-burning process. Some studies have found that fat production may actually be reduce by as much as seventy percent when taking hyroxycitric acid. Studies have determined the significant weight-loss benefits on both animals and humans when using garcinia. One study, which involved fifty obese patients, gave 500 mg of garcinia rind to these patients daily, along with 100 mg of chromium. This was also combined with a low-fat diet. The individuals who were taking the garcinia-chromium lost an average of eleven pounds, while the control group reported only a four-pound weight loss.

Garcinia has been found to be beneficial in curbing the appetite, which aids in weight control and obesity. One study on animals found appetite reduction in lean and fat rats and mice. The animals ate less, and when hyroxycitric acid was added to their diets, their body fat decreased, but body protein was unaffected.

Garcinia is also thought to help burn fat through thermogenesis. When there is not enough thermogenic activity, weight gain can result. The thermogenic activity in garcinia is responsible for helping to increase heat production, specifically in brown fat, which is the body fat surrounded by blood vessels and energy cells. Brown fat is harder to lose because it requires more heat to burn.

The fruit of the garcinia plant is used to provide anorectic, anticatarrhal, astringent, demulcent, and thermogenesis properties. Primarily, garcinia is extremely helpful in dealing with excessive appetite, obesity, and weight-related conditions. Look to your local or internet health food store for this and other great products to help with weight loss.

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L-Methionine
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Date: May 02, 2009 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Methionine

Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body.

Maintenance of Cell Membranes

It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine.

This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids.

Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics.

A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis.

Muscle Development

Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue.

Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows.

Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow.

Detoxification of the Liver

Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine.

Methionine and Autism

Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals.

Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below.

Miscellaneous Benefits

Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system.

It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract.

Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems.

So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most.

Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine.

Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement.

Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.

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Huperzine And Memory
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Date: December 04, 2008 01:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Huperzine And Memory

Chinese club moss goes by the name Huperzia serrata, and gives its name to the sesquiterpene alkaloid it contains: huperzine A. This alkaloid has been found to be a superstar in the arena of brain-saving treatments for conditions such as Alzheimer's and age-related senility. Studies in China have found up to 60% improvements in the cognitive functions of such patients, and its potential has been recorded in the Journal of the American Medical Association. This is no mere folk remedy, and is the subject of serious study.

Known as Qian Ceng Ta, Chinese club moss has been a part of traditional Chinese medicine for centuries for the treatment of fever and inflammation, which is not surprising considering that most plants contain antioxidants and anti-inflammatories. However, what is unusual is the fact that it has also been found effective in treating some forms of dementia and depression, and also helps to reduce the incidence of panic attacks in those susceptible to them.

Not only that, but the plant has been found to possess diuretic properties, and a reduction in the swelling associated with water retention could also help to reduce the pain and other effects of swelling and inflammation. However, for now it is its effect on the brain that we are concerned, and research has indicated the likely mechanism by which huperzine A works.

Huperzine is an enzyme inhibitor - specifically inhibiting the enzyme acetylcholinesterase that breaks down acetylcholine, a neurotransmitter involved in the processes of memory, learning and mood. Outside the brain, it is involved in the movement of skeletal muscle tissue as well as in the regulation of cardiac and other smooth muscles such as those of the blood vessels.

When acetylcholinesterase (AChE) attacks acetylcholine (ACh), the latter attaches to a chemical site on the enzyme where it is then destroyed. It is a deliberate function of the body, designed to terminate a synaptic transmission. The purpose of a neurotransmitter is to allow the transmission of an electrical impulse form one nerve cell to another over a gap between them known as a synapse. Once the transmission has been completed, the enzyme can destroy the neurotransmitter, and then another takes its place. In fact one molecule of AChE can destroy around 5,000 molecules of ACh.

However, with age and for other reasons, these neurotransmitters can become depleted so that it becomes increasingly more difficult for brain cells to communicate with each other, and their destruction becomes undesirable. There are drugs available to help prevent this happening (e.g. donepezil, galantamine and tacrine), and so help to improve the memory and mental function of people as they grow older or contract conditions such as Alzheimer's disease.

Huperzine A has been found to take up the site in the acetylcholinesterase molecule that would normally have been used by the acetylcholine, and so save it from destruction. The more Huperzine A molecules present, the more acetylcholine available to pass messages between brain cells, and the stronger the cognitive function of the subject or patient. The pharmaceutical drugs mentioned in the previous paragraph work in exactly the same way.

This is a very specific reaction, one molecule adopting exactly the same space as the other, and has been proved scientifically by comparing the physical shapes of the two molecules. It's just like a jigsaw puzzle, where only one piece can fit into each position. Except here there are two: Huperzine A and acetylcholine both fit into the exact same place in the chemical structure of the acetylcholinesterase molecule.

The biochemistry of the reactions involved is very complex, and shall not be discussed here, but the upshot is that Huperzine A can do exactly the same job as modern drugs to avoid this hydroxylation of the ACh needed for the proper functioning of your brain.

In fact, clinical trials have indicated Huperzine A not only to be comparable in effect to the drugs current used, but also likely safer with respect to the possible side effects. This has still to be confirmed, but the National Institute on Aging is currently carrying out a trial to evaluate this claim in tandem with its effect on Alzheimer's disease. It has also been examined at Harvard University for its effect on epilepsy on patients with whom alternative pharmaceutical treatments have been unsuccessful.

Another suggested benefit of Huperzine A is that it is an NMDA (N-methyl D-aspartate) receptor antagonist that provides protection against damage to the brain by an excess of glutamates, and that it can also help to protect nerve cells from damage. Since NDMA is responsible for the transmission of some types of pain, the antagonist can also act as an analgesic.

There are other benefits that Chinese club moss can provide, and myasthenia gravis is one of them. Although relatively rare, this is a serious condition in which acetylcholine receptors are deactivated on muscle cells. This is achieved through the autoimmune system malfunctioning and creating antibodies against the receptors, and the end result is paralysis and respiratory failure.

Huperzine A reduces the AChE available and so might possibly enable the acetylcholine to work more effectively and delay or even stop the deterioration of muscle function. When people hear of muscle paralysis they frequently forget that breathing requires muscle function, as indeed does your heartbeat. This is currently surmise, and studies are being carried out to determine whether or not this usage of Huperzine A is viable.

Another promising application of Chinese club moss extract is in preventing organophosphate poisoning. These pesticides permanently suppress acetylcholine. This results in seizures due to a lack of interruption of the signals from nerves to muscles. The seizures can result in rapid death from uncontrollable seizures, or from permanent contraction of the diaphragm muscle that allows breathing. Although no human studies have yet been carried out, animals given Huperzine A prior to organophosphate exposure have survived without seizures.

There are no doubts that Chinese club moss and the Huperzine A extracted from it are effective in preventing the suppression of acetylcholine, and in permitting the proper activity of this important neurotransmitter. It is finding an increasing number of potential uses beneficial to the human body, not the least of which would be a partial remedy for some of the effects of dementia and Alzheimer's disease.



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Feverfew Leaves
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Date: July 31, 2008 02:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Feverfew Leaves

Feverfew is most commonly used in the treatment and prevention of migraine headaches. Migraines are extremely common and can be very difficult to treat. Other methods of relieving pain have been explored because, for many migraine sufferers, conventional treatments have not been successful. Feverfew is one of the most successful forms of alternative treatments that have been found for treating migraines. Many studies have been conducted which have validated the already existing knowledge of many herbalists: feverfew is a great tool for helping to prevent migraines in many cases.

Although feverfew had long been used for treating headaches, its popularity declined with the advent of modern medicine. The herb has resurged into medical interest after the wife of a doctor who worked for the British National Coal Board had been suffering from migraines and was told by a coal miner to trey chewing on two feverfew leaves a day. After trying the herb, the woman noticed improvement, with fewer and less severe migraines. Her husband then urged a migraine specialist in London, Dr. E. Stewart Johnson, to test feverfew, with the results of several studies now showing it to be effective.

Dr. Johnson agreed to try the herb because he had many patients who had been suffering from migraine pain for years and had yet to find a successful treatment. Originally, he tried the herbal remedy on only ten of his patients. The results of this trial were so promising that it led to a study of another 270 of his patients, with seventy percent reporting that they received significant improvement when receiving feverfew for their headache pain.

Following this, a group of researchers in the City of London Migraine Clinic were led by Dr. Johnson to conduct a study, which was reported in the British Medical Journal, investigating seventeen patients who had already been using feverfew for at least three months. All were asked to discontinue use of their original method of treating with feverfew. Eight patients were given a capsule of feverfew, while the other nine were given a placebo.

Those that were given a placebo had an increase in frequency and severity of headaches, nausea, and vomiting, while those that were given feverfew capsules had no increase in frequency or severity of their migraines. This research has led to the belief that feverfew is advantageous in the prevention of migraines. Many other studies have been done to further test the effects of feverfew. It has been concluded that feverfew treatment is effective and there were always definite improvements in the group that used feverfew. Additionally, there were no serious side-effects that appeared to exist.

Feverfew seems to have similar properties as NSAIDs such as aspirin and ibuprofen. Also, the parthenolide that is found in feverfew is the main inhibitor for the formation of compounds that promote inflammation. Parthenolide reduces the secretory activity of blood platelets and white blood cells. This is important because migraines are thought to be associated with abnormal platelet behavior, as they are responsible for the release of serotonin, which constricts blood vessels and leads to migraine pain.

Feverfew is now recognized by the British and Canadian governments as a migraine treatment and is often prescribed by doctors. Many physicians and pharmacists have recent began to take more interest in the use of herbal remedies, especially since patients are beginning to become more interested in natural methods of healing.

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Shark Cartilage
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Date: April 30, 2008 03:03 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Shark Cartilage

Sharks do not have skeleton of bone but of cartilage, which is a dense form of connective tissue. Its main components are cells known as chondrocytes that are responsible for producing collagen fibers, an elastic protein called elastin that is responsible for the skin returning to its original shape after being pinched, and ground substance that is rich in proteoglycan, a protein with glycosaminoglycan chains.

Shark cartilage is said to be beneficial in the treatment of many conditions including arthritis, psoriasis (allied to arthritis), rheumatism, eczema, acne, allergies and the most controversial – cancer. It is said to inhibit tumor growth by inhibiting angiogenesis – the formation of new blood vessels by growing them from old ones. This can lead to metastasis, or the spread of cancer between organs and also feed the cancer cells with blood.

Shark cartilage has been used medicinally for thousands of years, particularly in ancient China where its use is documented, and might also have been in other areas where the consumption of fish was high. However, the production of shark cartilage and its trade is not well documented. The major cartilage consuming countries are Australia, India, Japan and the USA, although it is used or consumed in many other countries, especially Hong Kong, Taiwan, China and, increasingly, Europe.

The best quality of cartilage is from the blue shark due to its higher chondroitin quality. Chemically, chondroitin is an acid mucopolysaccharide, and a very large molecule that is used for a variety of purposes. In arthritis it is difficult to get it to the source of the problem due to its physical size and large doses are used to ensure that at least a proportion passes through the capillaries to the joints.

Arthritis is a particularly prevalent disease and comes in two forms: osteo- and rheumatoid arthritis. Osteoarthritis develops over a long period of time, and generally the cartilage roughens and becomes thin, while the bone becomes thinner. Extra synovial fluid, that lubricates the joint, can be formed and that causes swelling. The bone tried to repair itself, but degeneration continues and the tendons become affected. Eventually inflammation can occur leading to severe swelling and pain. There are several causes, the most common being injury or repetitive hard use of the joints.

Rheumatoid arthritis, on the other hand, is completely different, and is caused by the immune system rather than wear and tear. The immune system mistakes parts of your joints as being foreign, and attacks the synovial membrane, or lining of the joint. It might also attack the sheath around the tendons. This eventually causes the cartilage to thin and the joints to wear, and the inflammatory response can cause painful inflammations. There is no apparent cause, though heredity, lifestyle and hormones might all be connected.

The effect of shark cartilage on arthritis is well documented, and in one study in the 1970s, only 11% of patients did not respond well to a treatment of cartilage injections. The pain relief the injections provided lasted from six weeks to over a year, though no reason could be provided for the vast difference. However, it did seem to demonstrate that the remedy was more than just a placebo. In another study involving bedridden osteoarthritis patients, eight out of ten could leave their beds after only three weeks of oral cartilage treatment. Shark cartilage appears to be effective when administered both intravenously and orally.

In a later placebo study involving 147 arthritis patients, they were given either shark cartilage or a placebo. Those with the placebo were encouraged to use other treatments when their pain became severe. After five years the placebo group reported a 5% drop in pain scores compared to 85% of the group taking shark cartilage. The joint deterioration in each group was assessed, and was considerably less in the cartilage group, who also lost less time at work through pain.

All of these results indicate that shark cartilage can be used to relieve osteo- and rheumatoid arthritis pain in at least 60% of sufferers. Since rheumatoid arthritis has been linked to psoriasis, this could also explain its effects on psoriasis. What the studies did indicate is that you need not wait five years to find if the treatment is effective or not: if you do not experience positive results within between four and six weeks, then shark cartilage treatment will likely not work for you.

There is no doubt that shark cartilage can provide relief to painful, swollen joints, and this is likely due to the mucopolysaccharides. It can also prevent the undesirable growth of new blood vessels into the cartilage and appears to help to regulate the immune system. These are also two of the reasons why it is believed by some to be an effective treatment for cancer by preventing metastasis.

It was the publication of the book “Sharks Don’t get Cancer” that started the rush for shark cartilage as a a treatment for cancer, but the problem is that sharks do get cancer – they even get cancer of the cartilage! However, that does not mean that the scientific reasons for the inhibition of metastsis are invalid. They are valid, and it is metastsis rather than the original cancer that ferquently leads to death. Metastsis is the spread of the disease round the body by the bloodstream, and shark cartilage appears to be able to help to prevent that. It also prevents the growth of blood cells into cancerous areas to feed the cancers with oxygen and other nutrients.

Although there are few reported side effects of shark cartilage, in the interest of safety it is advised that children and pregnant women should avoid it. The same is true of people recovering from recent surgery since it could slow healing due to its effect on repairing blood vessels. If you have a low white blood cell count, do not have a shark cartilage enema since it can cause a potentially fatal infection.

Otherwise it should be safe to take, and is available in many forms including creams, capsules, powders and injections. The recommended dosage is 1 gram dried shark cartilage for each 7 Kg (15 lb) body weight. Once you begin to see an effect on the pain of your arthritis, one can then try to reduce the dose to 1 gram for each 18 Kg (40 lb) body weight.

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Take Charge Of Your Health With Herbal Bio-Identical hormones
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Date: November 04, 2007 03:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Take Charge Of Your Health With Herbal Bio-Identical hormones

Bioidentical hormones assist women in overcoming acute menopausal symptoms, while improving skin. They help by strengthening bones, keeping the mind sharp, promoting energy and well-being, and helping to preserve vaginal tone and resist vaginal dryness. In men, these hormones add energy and vitality, while improving muscle tones and mental sharpness. Bioidentical hormones (BHRT) are exact duplicates of the hormones that are produced by the body. However, they are much more easily metabolized by the body into safe forms of estrogen than their counterparts, which stimulate toxic metabolites. When they are used in physiologic amounts, bioidenticals carry much fewer risks than synthetic hormones. However, despite the fact that research supports their use and proves them safe alternatives to prescription drugs, few physicians are actually using these hormones in their practices.

Those patients, who wish to address menopausal and andropause symptoms, or to achieve lifelong hormonal balance in order to prevent illness, often do not know where to go to find a comprehensive bioidentical hormone replacement program. Instead, they read whatever they can to formulate a plan and purchase various products that are available over the counter, often spending precious time and money on programs and products that don’t do what they’re expected to do. One of the most common errors among people is putting together a program based solely on symptoms instead of first checking hormone levels. Symptoms may overlap from one hormone pattern to another. If you try to replace or augment specific hormones without having an accurate test of the levels first, your results will seldom be good.

If your doctor is prescribing transdermal hormones, make sure to do a saliva self-test to measure your hormones levels as it is much more accurate and revealing than other types of tests. You can submit your samples to Mead Labs, where you will actually receive a telephone consultation from a health professional to interpret your results followed by a program of products prescribed especially for you from one of their medical professionals. With your own results, you can learn a lot about the exact state of your hormones instead of blindly guessing from symptoms which may be similar. For example, men may not need testosterone shots or transdermal patches, as the results may show estrogen dominance. The answer for this is not adding more testosterone, because the man could be converting testosterone into estrogen, but instead a program including special herbs and nutrients may be much more beneficial. No matter your gender, your health professional at Mead Labs will design a safe and effective program based solely on bioidentical hormones, herbs, and nutrients first. In the past years, when prescription, non-bioidentical HRT was used by any women with menopausal symptoms, there was no testing to find out what kind of imbalance was actually occurring. Proponents of BHRT are trying to ensure that this method of prescribing the same combination and amounts of medications to everyone is not used with natural hormones. Because hormone profiles and levels can vary significantly from person to person, even those people in the same gender, testing hormones levels and obtaining recommendations from a medical professional who is experienced in BHRT are the key points to ensure you benefit from this therapy.



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Lutein - A plant pigment provides sun protection from the inside out.
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Date: July 09, 2007 01:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lutein - A plant pigment provides sun protection from the inside out.

A plant pigment provides sun protection from the inside out.

 

Energy on earth begins with the sun’s rays, which spark the photosynthesis in plants that ultimately powers all life. (Petroleum is the residue of prehistoric plants crushed over eons into liquid form.) But the sun’s energy is not totally benign for us humans; excess exposure can cause skin to wrinkle and eyesight to dim.

 

Enter lutein. This plant chemical, reddish-orange like the setting sun, has become a hot commodity over the past several years because of its ability to protect both eyes and skin against sun damage. A member of the carotenoid family of nutrients, lutein is generally paired with its partner, Zeaxanthin, in a wide variety of foods, including egg yolks, fruits, corn and leafy greens such as spinach (where its bright color is masked by the green of chlorophyll). That’s a good thing, since your body can’t make lutein and so needs to obtain it from your diet.

 

Skin Shield

 

The sun produces a whole spectrum of light rays, from the visible (red through violet) to the invisible or ultraviolet (UV). UV rays—both ultraviolet-A (UVA) and ultraviolet-B (UVB)—are troublemakers. They attack collagen, the protein that gives skin its shape, which leads to wrinkles and other signs of aging. What’s worse, UV is also capable of damaging skin cell DNA, a process that can promote cancer development. And UV isn’t the only culprit: The sun’s visible blue rays are believed to help create harmful molecules called free radicals within the skin.

 

The clue to lutein’s importance in fending off skin damage lies in the fact that it is found throughout both the outer (epidermis) and inner (dermis) skin layers, where as an antioxidant it fights free radicals and as an orange pigment it soaks up blue light. In one study, using lutein both orally and topically produced improvements in skin hydration and suppleness (Skin Pharmacology and Physiology 4/19/07). Lutein has also shown an ability to counter the inflammation and immune system suppression associated with excess UV exposure (Journal of Investigative Dermatology 2/04).

 

Lutein Gleanings

 

What is it? A red orange carotenoid found in a number of fruits and vegetables, generally with a similar compound called Zeaxanthin.

 

What does it do? This powerful antioxidant helps protect the eyes against both cataracts and age-related macular degeneration (AMD); it also appears to defend the skin against sun damage and has been associated with reduced arterial wall thickness, a measure of cardiovascular health.

 

The Eyes Have It

 

Your eyes, like your skin, are directly exposed to the sun’s UV rays. Such exposure can cloud the eye’s lens to create cataracts. It can also disrupt the retina at the back of the eye particularly the macula, the part of the retina responsible for clear central vision—which can result in age-related macular degeneration.

 

Not surprisingly, the eye is yet another one of the body’s lutein hot spots. This pigment is especially concentrated in the macula; in fact, of the 600 or so carotenoids that exist in nature, only lutein and Zeaxanthin are found within this all important structure. So it also isn’t surprising to learn that they Eye Disease Case Control Study, one of the first large-scale investigations into carotenoids and eye health, found a link between reduced AMD risk and high levels of lutein and Zeaxanthin. Current research has focused on the use of supplemental lutein in AMD patients, with promising results.

 

It isn’t only the outside of your body that may benefit from lutein. When oxidized by free radicals, LDL cholesterol settles into arterial walls. Lutein may help slow this process; in one study, people with the most lutein in their blood had 80% less vessel-wall thickening than those with the least (circulation 6/19/01).

 

So enjoy some fun in the sun. But respect the power of those golden rays, and let lutein help make playtime a safe time. –Lisa James.

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Papaya- May Be A Fountain of Youth
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Date: May 31, 2007 02:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Papaya- May Be A Fountain of Youth

Papaya- May Be A Fountain of Youth

 

Seventy years ago, when the Social Security Administration was developed during the Great Depression, age 62 was recognized as average life expectancy. These days, getting older is a whole different ball game. Not only are people living well into their 80s and 90s, they’re living better, too. People well into retirement are mountain biking, kayaking, jogging and hiking, as well as gardening, golfing and attending concerts – sometimes for their first time. Everybody, it seems, is on the go, from ages of 22 to 92.

 

Of course, you don’t have to wait until retirement to start planning for a longer more vibrant life. The best way to ensure happier and longer years ahead is to start young.

Nobody wants to spend retirement in the doctor’s waiting room or have their golden years intruded upon with illnesses or infirmities. And, most importantly, we don’t want to feel 80 years old even though our driver’s license says we are.

These desires and demands are not just wishful thinking. Huge advances in the understanding of how men and women age are being made almost daily. These findings are helping to improve our chances of living long, healthy lives. And, some of the most impressive findings have shown that using nutritional supplements can help – in particular, a specially formulated papaya preparation is able to fight two of the primary reasons we get old – oxidative stress and immune system decline.

This issue of Ask the Doctor is going to share the anti-aging secrets hidden in the papaya and how this tropical fruit may hold the key to a long, vibrant life.

 

Q. Why papaya? What does papaya have that other fruits and vegetables don’t?

A. Not many American moms put a papaya in their kids’ lunch boxes and papaya pie has yet to gain a following. But this tangy tasting fruit is now appearing fairly frequently in the produce departments of most grocery stores and its popularity seems to steadily increase each year.

The papaya’s bright orange flesh is fairly fibrous and very slippery – slicing a peeled papaya is a little like slicing a bar of wet soap. The core is filled with little black seeds that look a lot like caviar. And while eating a papaya will give you a day’s worth of vitamins A and C as well as potassium taking Fermented Papaya Preparation (or FPP) might just give you an additional 30 years of healthy vibrant life.

 

Q. What exactly is Fermented Papaya Preparation (FPP)?

A. It’s a specialized nutritional supplement. Backed by more than 30 studies to date, FPP has been used in Japan for decades. It’s also an extremely popular supplement in France and other parts of Europe. FPP begins with fresh, ripe papayas that are slowly fermented by a natural process that takes several months to complete. The fermented papaya is then dried and ground into a fine powder. This phytonutrient-rich powder can then be sprinkled in the mouth, dissolved, and swallowed.

 

Q. How was FPP developed?

A. Japanese scientists noticed that individuals with higher amounts of papaya in their diets experienced certain health benefits.

Researchers who study aging decided to look at the papaya’s chemistry to see if it might have properties that could contribute to longevity. Several plant chemicals in the papaya showed promise. And when they combined papaya with specific yeasts and traditional Japanese fermentation techniques, FPP was born. This unique substance was then subjected to scientific studies to see its health impact; they determined that FPP is a superior antioxidant, a powerful immune-booster, and one of Japan’s secrets to a long healthy life.

 

Q. How does FPP help people live longer and healthier?

A. While getting older is an indisputable fact of life, aging, per se, is not. We can’t do much about our annual birthdays and we really shouldn’t even if we could. Every age is a cause for celebration and every life experience, both the difficult and the sublime, should be treasured.

However, we don’t have to accept the consequences of aging that can make a mockery of the “Golden Years” - heart disease, Alzheimer’s disease, Parkinson’s disease, osteoporosis, arthritis, and cancer. Our parents and grandparents and the generations that preceded them might have had little say in how they aged. But we can. We can slow down the harmful effects of aging and FPP can help by reducing oxidative stress and immune system decline.

Additionally, fighting oxidative stress helps people retain their youthful appearance longer. Oxidative damage is the number one factor in facial aging.

 

Q. What exactly does oxidative stress mean and what does it have to do with aging?

A. One theory of aging is that harmful molecules called free radicals wreak havoc in our cells. Many of our body’s normal metabolic processes produce free radicals. For example, free radicals are a normal by-product in the production of ATP (the energy molecule) from glucose. Certain types of white blood cells destroy invading microbes by the production of free radicals. Free radicals are also formed by the many normal enzymatic actions that take place every minute every day.

However, outside sources can also cause free radical formation, as well. If we are exposed to pollutants in the environment, chemicals, additives and preservatives in the food we eat, or even direct sunlight, excess production of free radicals can occur, causing profound damage. This free radical frenzy is called oxidative stress, and is linked to almost every disease of aging including arthritis, heart disease, cataracts, Alzheimer’s disease, Parkinson’s disease, and cancer. In fact, the reason why these are called diseases of aging is because the longer we are alive, the longer we are subjected to these free radical assaults.

 

Q. How does FPP affect the decline of our immune systems as we age?

A. Our immune systems consist of specialized tissues, organs, and cells, including several different kinds of white blood cells. Each type of white blood cell works in specific ways to keep us healthy and free of disease. They not only stand guard – on the alert for invaders – they can fight and eradicate microbes, too.

However, as we age, our white blood cells become less efficient in keeping viruses and bacteria from infecting us. They often mistake invaders for good guys, like nutrients. As they age, white blood cells may recognize foreign invaders, but be too tired to fight and let them in. This age-associated immune decline also results in single cancer cells being able to “take hold” and grow into tumors. By the time the white blood cells realize their mistake, the cancer is a widespread disease.

That’s why older members of society have more urinary tract infections, more pneumonia, more cases of bacterial meningitis, tuberculosis, herpes zoster, and much more cancer than younger adults do. Moreover, mortality rates for these diseases are often 2-3 times higher among adults than younger people with the same disease.

FPP steps in and takes charge. One kind of white blood cells, the macrophage “eats” and digests bacteria, viral particles, and free radical fragments. Research has shown that FPP helps macrophages work faster and ingest more disease-causing microbes. Scientists have also discovered that FPP increases the production of a chemical protein called interleukin that’s secreted by macrophages. Interleukin plays an important part in wound healing and keeping minor infections from becoming major infections.

Another important immune system cell is the natural killer (NK) cell, a white blood cell that is continually on the prowl for cancer cells. As the immune system ages, NK cells have trouble “seeing” cancer cells. Researchers have discovered that FPP boosts the activity of NK cells. Increased NK cell activity can result in the increased killing of cancer cells as well as cells infected by viruses.

 

Q. How does FPP help protect us from free radical damage?

A. FPP contains unique and powerful antioxidants. Antioxidants are molecules that neutralize free radical damage. Antioxidants do this by donating an extra electron to the free radical without becoming frenzied or worked up into a free radical themselves. Although the antioxidant has donated an electron, it has a more stable “personality” and is less reactive. This action stops the domino effect and ongoing free-radical damage.

If you consider your body a temple, think of free radicals as stealing bricks from your temple’s foundation. FPP acts not only as policeman, but as a builder as well. It doesn’t just stop the theft of bricks; it helps create new ones, keeping the foundation strong and young.

FPP does this by affecting super oxide dimutase (SOD) and glutathione peroxidase (GPX), the very genetic pathways that eliminate free radicals from the system. FPP is more than an antioxidant – it doesn’t turn into a pro-oxidant if you happen to take a large dose the way standard antioxidants can. Consider it an “antioxidant plus.”

Since aging is largely determined by how well our bodies can fight oxidative damage, using FPP can slow down the clock as it bolsters natural abilities with its own potent neutralizing activities.

 

Q. What else does science say about FPP?

A. As the subject of over 30 clinical studies, FPP has been shown to inhibit dangerous hydroxyl free radicals. In addition, it is also being considered for its immuno-protective effects.

Researchers and medical professionals have been studying FPP for years, tracking its effect on the immune system and aging. In fact, no less a personage then Dr. Luc Montagnier, co-discover of HIV 1 & 2 virus, has been conducting research on this natural immune booster.

Dr. Montagnier recommends using FPP as part of a tri-therapy (including antibiotics) that reduces the proliferation of the virus and stimulates the immune system. Since FPP has antioxidant and immuno-stimulative properties, it seems like an obvious choice for a combined approach to combating AIDS. Because of the higher free radical production in stage II of HIV infection, Montagnier believes that reducing this oxidative stress at the earliest stage of HIV infection may be a key factor.

In HIV-infected patients, the glutathione system is depressed even at the early stages. As part of a combination treatment, FPP increased the numbers of CF4 lymphocytes helped with weight gain and increased hemoglobin levels.

One scientific study showed the ability of FPP to inhibit dangerous hydroxyl and hydroxyl-like free radicals, while enhancing the production of protective super oxide. Other research by Dr. Lester Packer, a professor of Molecular Pharmacology and Toxicology at the University Of Southern California School Of Pharmacy, shows FPP to have natural iron chelating effects and prevents lipid peroxidation.

And, in one randomized, double blind, placebo-controlled clinical trial, patients with cirrhosis of the liver were given FPP or a placebo. The results showed that 81.2% of the patients survived in the FPP group compared to 38.5% of participants in the placebo group.

These studies and many others like it, show that FPP can neutralize the effects of oxidative stress on disease states as well as slowing the normal aging process.

 

Q. So if we can prevent oxidative damage to our cells AND prevent decline in our immune systems, how much longer can we expect to live?

A. Most theories of aging and almost all researchers who study aging claim there IS a limit to how long the human body can remain viable. However, the oldest age achieved so far was 128 by a woman named Ma Pampo who lived in the Dominican Republic. Other notable oldsters include Jeanne Louise Calment of France, who lived to be 121; Elena Slough, of Trenton New Jersey who lived for 114 years and 112-year old Mary Dorothy Christian who lived and died in San Pablo, California.

Right now, Japanese women have the longest life span of any country in the world, with an average life expectancy of 85.93 years. Japanese men live an average 78.87 years. Japan also has more centenarians – people living to age 100 and beyond – than any other country as well. There is no reason why the rest of the world, the USA included, can’t achieve these average life expectancies and, hopefully, even surpass them.

 

Q. Is FPP safe?

A. Yes, it is. Many health-conscious people in Japan and Europe have used FPP for many years as an anti-aging product without any side effects.

 

Q. What is the recommended dosage level of FPP?

A. Dosages of FPP vary depending on individual needs and usage. For basic anti-aging support, 3 grams per day is fine. For additional support, up to 9 grams per day is recommended. To add a boost to your immune system when you need it, start out with 6-9 grams a day for the first 2-3 days (at the beginning of a cold, for example) and then move back down to 3 grams per day.

For individuals looking for optimum immune support, Dr. Montagnier advises morning and evening doses, preferably on an empty stomach.

 

Conclusion

As America’s Baby Boomers turn 65, they are living proof that the milestone is no longer the herald of old age. It’s just one more stepping stone from where we’ve been – to where we are – and on to where we want to go. Using Fermented Papaya Preparation, we can feel younger, look younger and live younger – to a very old age.



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Safe Solutions for Chronic Pain
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Date: March 30, 2007 12:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Safe Solutions for Chronic Pain

Safe Solutions for Chronic Pain

 

One of the biggest challenged in healthcare today is the problem of pain. There are simply too many people living each and every day with ongoing, unremitting chronic pain. And there are far too many healthcare providers who – for a variety of reasons – are failing to adequately address this serious problem.

Recently, 368 doctors who routinely care for patients with chronic pain agreed to take part in a unique study. The doctors were surveyed about the pain medicines hey prescribe, what kind of treatment goals they hope to achieve, and how they felt about their ability to help their patients. They were also presented with four chronic pain vignettes or mock case studies and asked to select the best treatment for each scenario from multiple choice answers.

Sadly, many doctors chose the worst treatment options in the case studies. The medications they reported using in their practices did not reflect current pain treatment standards. They tended to set low treatment goals 0 instead of aiming for a least a 75% reduction of pain for their patients, they settled for 10% to 20% reductions. And many of the doctors admitted they lacked confidence in their ability to relieve their patients’ pain and suffering.

Adding to the challenge are the almost daily news announcements about dangerous side effects in certain pain medications. Synthetic prescription COX-2 inhibitors, once hailed as the safest of drugs, have been linked to heart attacks, strokes, blood clots, and intestinal bleeding. The over-the counter (OTC) drugs aspirin and ibuprofen kill over 16,000 people each year. And acetaminophen, the most widely used pain reducer in the United States is the leading cause of drug-induced liver failure.

As a doctor specializing in chronic pain disorders, I know that optimal pain management can be a real challenge. However, I also know:

-You do not have to live in chronic pain.

-Your chronic pain, no matter what the cause, can be reduced, and usually

eliminated.

-Chronic pain can be relived both effectively and safely with powerful all-natural

compounds.

Q. What is chronic pain?

A. Sudden, or acute, pain occurs when pain signals immediately fire in your nervous system alerting you to an injury, like a broken ankle, or an illness, such as appendicitis. Once the injury heals or the illness is cured, the transmission of pain signals stop.

Ongoing – or chronic pain – is much different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial injury, such as sprained back muscles, or an initial illness, such as a serious infection. There might be an ongoing cause of pain, such as arthritis, cancer, or fibromyalgia. Chronic pain also occurs without any past injury or evidence of body damage.

The most common kinds of chronic pain are headache, low back pain, cancer pain, arthritis pain, and neurogenic pain (pain resulting from damage to nerves or to the nervous system itself). While chronic pain differs in its origin and where it occurs, it is generally your body’s way of saying that something urgently needs attention, and will not o away unless its underlying causes are addressed.

These causes can usually be determined if you remember the acronym “SHIN”. This stands for Sleep, Hormonal deficiencies, Infections/Inflammation/Impingement, and Nutritional deficiencies. When these are treated, pain often resolves.

Q. Why is it so hard to effectively reduce chronic pain?

A. Unfortunately, many physicians’ entire education in pain management consists of “giving nonsteroidal anti-inflammatory drugs or NSAIDs (pronounced en-sayds), COX-2 inhibitors, or acetaminophen and considering narcotics if the patient has cancer.

Some NSAIDs, like aspirin and ibuprofen, are available over-the-counter, while others, like the synthetic COX-2 inhibitors are only available with a doctor’s prescription. These mediations are usually inadequate and often toxic when used for chronic pain. And they do not address the problem(s) that the pain is trying to alert you to.

Q. What exactly are COX-2 inhibitors?

A. COX-2 inhibitors do pretty much what their name implies – they inhibit a natural enzyme in our body called the clclooxygenase-2, or COX-2, enzyme. There are two COX enzymes – COX-1 and COX-2 and both complete several actions in our bodies. One very important action that both COX-1 and COX-2 enzymes share is the speeding up of our body’s production of prostaglandins. These hormone-like substances are made by the cells of the body and have several important functions.

Some of the most powerful prostaglandins cause inflammation, pain, and fever when we are sick or injured. Prostaglandins also protect the lining of the stomach from the damaging effects of acid. Other prostaglandins make sure our platelets (important blood cells) make blood clots when needed. Still others help our kidneys get rid of unwanted salt and water. And researchers have just recently recognized the importance of still another prostaglandin that protects our heart and blood vessels.

The NSAIDs reduce pain by reducing prostaglandin production by blocking or inhibiting the COX enzymes. In theory – less prostaglandins, less pain and welling seems reasonable. But if you really stop and think about it, it’s pretty easy to understand why this method of pain relief might result in significant consequences.

Pain and inflammation are often needed for healing. And just as needed is the protection of our stomach lining, blood clotting ability, assisting kidney function, and keeping our blood vessels healthy. And scientists are beginning to understand if you interfere with one natural response, you may be disrupting the body’s ability to prevent extremes and imbalances.

That’s why using aspirin and ibuprofen can result in stomach ulcers, kidney problems, and internal bleeding. And that’s why using synthetic COX-2 inhibitors can result in high blood pressure, blood clots, heart attacks, and strokes.

Q. Why are we just now learning about the dangers of COX-2 inhibitors and other NSAIDs?

A. That’s a good question!

Many people over the age of 65 have chronic pain conditions and are frequent users of OTC and prescription NSAIDs. This age group also experiences heart disease and Alzheimer’s disease in greater numbers. So, if a 70 year old woman who’s been using Celebrex for the past two years for arthritis in her knees suddenly has a heart attack one morning, it would not be entirely unexpected.

For the past five or six years, researchers have been studying the possibility that NSAIDs may prevent certain cancers, Alzheimer’s disease, and other health problems. The ongoing, close scrutiny of large group of people taking these medications by scientists who were conducting these studies has resulted in the discovery of these dangers.

Q. What kind of natural compounds relieve chronic pain?

A. There are many – glucosamine, Omega-3 fatty acids, the B vitamins – the list goes on and on. Instead of disrupting normal bodily responses, these natural compounds work in harmony with our body to eliminate chronic pain. Three very powerful and very effective all natural plant compound pain and inflammation relievers are Sweet Cherry, Boswellia serrata, and White Willow Bark.

For many years there have been anecdotal or personal reports that claimed eating Sweet Cherries, specifically Prunus avium, wipes out back pain, arthritis, and gout. While anecdotal reports generally don’t account for much in the world of science, he sheer numbers of testimonials proclaiming the Sweet Cherry’s amazing ability to reduce pain made researchers sit up and take notice.

When Sweet Cherries were examined in the lab, it was easy for scientists to understand how this natural fruit is able to relieve pain. It seems Sweet Cherry’s bright red color is the key. Like many deeply colored fruits, Sweet Cherries are full of flavonoids called anthocyanins and proanthocyanidins.

These powerful plant compounds scavenge and destroy altered oxygen compounds called free radicals. Many degenerative, chronic diseases have been associated with the tissue damage caused by free radicals, including arthritis, heart disease, peripheral artery disease, and cancer. Cherry fruit extract is a natural anti-inflammatory compound, making it an excellent treatment for arthritis, fibromyalgia, and other chronic pain and inflammation diseases.

A pain relieving plant compound that comes from the bark of a tree, Boswellia serrata has been used by Indian healers for hundreds of years to reduce painful inflammation. When 20th century researchers looked at extracts of Boswellia Gum Resin in the laboratory they discovered the presence of powerful plant compounds, called boswellic acids.

Researchers found Boswellic Acids reduce inflammation in several ways. They open constricted blood vessels, improving blood flow to joints. They balance levels of leukotrienes – specific chemicals in the body that cause inflammation. And Boswellic Acids block two inflammatory chemicals that increase in asthma and inflammation of the colon. In addition to being helpful in treating these 2 illnesses, Boswellia has also been clinically studied and found to be quite effective in osteoarthritis and rheumatoid arthritis without any evidence of ulcers or stomach irritation.

Another bark extract, White Willow Bark is one of the oldest and most effective pain relievers. For over 2,000 years extracts from the bark of the White Willow tree have been used to ease aches and pains and reduce fevers. It is the original source of aspirin, but when used as the entire plant medicine, White Willow Bark is much safer than aspirin and quite effective.

White Willow Bark’s active ingredient is salicin and the combination of other compounds in the bark significantly enhances its pain killing power. In two large clinical trials of patients with chronic low back pain. White Willow Bark was found to be not only safer and much more effective than standard prescription therapies, it was also 40 percent more cost effective.

Salicylic acid from White Willow Bark lowers the body’s levels of prostaglandins, easing both acute and chronic pain. White Willow Bark reduces the pain and swelling of arthritis, headache, back and neck pain, muscle aches, and menstrual cramps. But, unlike aspirin, it doesn’t cause stomach bleeding or other known adverse effects.

Q. Do Sweet Cherry, Boswellic Acids, and White Willow Bark work on many kinds of chronic pain?

A. They do indeed. Because they reduce both pain and inflammation by a broad combination of actions, these natural extracts have been proven to be excellent against arthritis, back pain, and pain from inflammatory intestinal diseases (Crohn’s disease and ulcerative colitis), and would be expected to be helpful in most kinds of pain.

Sweet Cherry, Boswellic Acids, and White Willow Bark relieve inflammation without causing stomach irritation, stomach ulcers, high blood pressure, blood clots, heart attacks, or strokes. That’s because these natural pain killers don’t disrupt the balance of enzymes or interfere with the body’s ability to prevent extremes and imbalances.

However, as with any pain therapy, Sweet Cherry, Boswellic Acids, and White Willow Bark work best when they are used as part of a comprehensive treatment plan to relieve the most common underlying causes of chronic pain or SHIN.

In addition, although these excellent natural remedies can often offer quick pain relief, natural remedies for severe chronic pains work best when they are given at maximum allowed doses and given 6 weeks to show their full effectiveness in combination with treating the pain’s underlying causes. The best chronic pain relief results when doctors and patients work together to meet the goals of treatment.

Some important last notes: Many causes of chronic pain are serious and life threatening. Everyone who is living with chronic pain must consult their doctor or other healthcare practitioner to determine the reason for their ongoing discomfort. In other words – make sure you know why you are having chronic pain and what’s causing the pain you want to relieve.

There are some types of chronic pain that only respond to opioids, or narcotic pain relievers. Morphine sulfate is an excellent pain medication and is used to relieve surgical pain, the pain of heart attacks, and pain from serious injuries. Morphine is also the very best drug for chronic cancer pain and non-malignant chronic pain. While many people fear opioids, these powerful pain killers can dramatically improve quality of life. If you are suffering with chronic cancer pain and you are hesitant to use morphine or another opioid, I urge you to discuss your concerns with your doctor other healthcare provider. No one with cancer should live with untreated or under-treated pain.

 

Conclusion

Even chronic pain can often be eliminated when SHIN is in combination with powerfully effective natural pain relievers. But, because some people may need to take pain relievers the rest of their lives, the medications they use must be safe as well as effective. The very safest come from natural plant compounds that have been studied for their ability to relieve chronic pain. You can become pain free and Sweet Cherries, Boswellic Acids, and White Willow Bark can help.



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Growing Older, Feeling Better
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Date: March 28, 2007 02:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Growing Older, Feeling Better

Growing Older, Feeling Better

 

Not long ago, when a man turned sixty-five, he became officially old – the best years of his life far behind him. The milestone meant his working days were done and if he was lucky, he might get four or five years to spend as he wished before illness and infirmity set in. It was simply expected and accepted that the older a man got, the sicker he got.

Well, not anymore. Today, a man age 65 is just as likely to be found hiking in the hills, running in a marathon, or even dancing in the streets than rocking in that proverbial front porch rocker. Because it’s becoming more and more evident that the older a man gets, the healthier that man has been.

Eating healthy, exercising, and kicking harmful habits (like smoking) can add years to a man’s life. Aging research is proving over and over again, that we can prevent and delay heart disease, cancer, diabetes, and Alzheimer’s disease – the major causes of disability and death in men over 50.

Now, it’s very true that good clean living from early on is preferable to sixty five years of bad habits and five years of good. But it’s also true that it’s never too late for men to make changes and vow to take better care of themselves. And one of the easiest and most effective ways men can improve their health is the addition of high quality nutritional supplements.

In this issue of Ask the Doctor, we’ll talk about specific dietary supplements that have been scientifically shown to improve the health of men over fifty, prevent the diseases that often strike at this crucial time in men’s lives, and actually slow the aging process.

 

Q. I just turned 50 and I’d like to begin taking nutritional supplements, but they seem so confusing. Where should I begin?

A. Many men feel the same way. There are literally hundreds and hundreds of nutritional supplements on health food store shelves. Figuring out which supplements provide the best health benefits for a 50+ man can be overwhelming.

The best foundation supplement is a high quality multivitamin. Research is repeatedly finding that even very healthy men who take daily multivitamins can significantly improve their health. In fact, an article published in the Journal of the American Medical Association (JAMA) recommends that all adult Americans take a vitamin supplement. Look for solid doses of vitamin supplement. Look for sol doses of vitamins and especially minerals. Multivitamins designed to be taken once a day are often woefully deficient in calcium, magnesium, and potassium. The only mineral a man should avoid is supplemental iron. Iron should only be in formulas for women prior to menopause. Men over 50 get all the iron they need from food and too much iron can cause health problems.

 

Look for men’s multivitamins that contain lycopene in the formula. Lycopene is the pigment that makes tomatoes red. The redder the tomato, the more lycopene is present. Numerous studies have shown that when men have high lycopene levels in their blood, they have a much lower risk of heart disease, age-related macular degeneration (a leading cause of vision loss) and prostate cancer.

 

Other important considerations are antioxidant blends, especially fruit- and tea-derived extracts; ginseng for energy and stamina; and digestive enzymes to aid in absorption and compensate for age-related decreased enzyme levels.

 

In fact, years of research has shown the foods a man chooses to eat (or not to eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of non-smoking related cancers.

 

Q. Aside from taking a quality multivitamin for general health, what nutritional supplements prevent and treat prostate cancer?

A. Six vital and all-natural nutrients can prevent prostate cancer from developing and even help fight the disease.

 

Calcium D-Glucarate

When men are exposed to excess levels of hormones, their risk of prostate cancer increases. A natural substance found in fruits and vegetables called calcium D-glucarate (or CDG), helps men’s built-in detoxification systems get rid of these harmful excess hormones.

 

Selenium

This antioxidant has powerful effects on the prostate gland. In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. The researchers found that selenium cut the rate of prostate cancer by 63%!

 

Green Tea

Green tea is the most widely consumed liquid in the world, after water. Men in China and Japan have been drinking it for centuries. They also have very low rates of prostate cancer. Research has discovered that potent plant substance in green tea called epigallocatechin gallate, or EGCG, can stop the growth of prostate cancer cells dead in their tracks.

 

Maitake Mushroom

For many years, maitake mushrooms, or dancing mushrooms, have been linked to good health in those who eat them. That’s because maitakes contain an important compound called D-fraction. A recent study showed that maitake D-fraction destroyed 95% of human prostate cancer cells in lab experiments.

 

Lycopene

Promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, so there has been an explosion of lycopene and prostate cancer research.

 

Q. What exactly happens to men’s hormones as they get older?

A. Just as women experience significant hormonal changes as they age, so do men. In fact, the term andropause has been used to describe men’s mid-life changes. Similar to menopause in women (where the decline of estrogen causes a myriad of symptoms), andropause in men signals the slow decline of testosterone, the chief sex hormone in men. While estrogen levels decline faster and more abruptly in women than testosterone levels do in men, testosterone decline can cause a number of unpleasant symptoms. These include abdominal weight gain, hair loss, reduced energy and sex drive, heart disease, and prostate enlargement. Whether a man labels these age-related changes as andropause or just the consequences of aging, most men will unfortunately experience some or all of them as their birthdays mount.

 

Q. So, is there a supplement that can give me the hormone level of a 20 year old?

A. Sadly, no, at least not yet! But there is a nutrient that can help the testosterone in a man over fifty “behave” more like a younger man’s testosterone.

 

A study that took place at the Fred Hutchinson Center in Seattle found that men who ate three servings of cruciferous vegetables – broccoli, cauliflower, or Brussels sprouts – every day had a 48 percent lower risk of prostate cancer. It seems a cruciferous plant chemical called diindolylmethane (DIM) that’s formed when broccoli is eaten, is the substance responsible for this impressive prostate cancer prevention. Since not many men could be persuaded to ea t broccoli for breast, lunch, and dinner every day researchers tried to extract DIM from these vegetables and make into a nutritional supplement. After many years of trying, scientists finally discovered a stable, all natural, and absorbable from of DIM.

 

The secret of DIM’s prostate cancer prevention is its ability to metabolize estrogen. While estrogen is generally thought of as a “female” hormone, a precise ratio of testosterone-to-estrogen is needed to maintain a man’s healthy sexual response, effective sexual function (erection of the penis and intercourse), strong bones and muscles, viable sperm, and a well-functioning prostate gland. As men enter their fifties, this ratio begins to change.

 

When men take DIM, however, their estrogen metabolism improves, testosterone metabolism accelerates, and the unwanted conversion of testosterone into estrogen is eliminated. This results in higher testosterone levels, similar to those seen in young men. As a result, DIM may speed weight loss, reduce prostate gland enlargement (benign prostatic hyperplasia or BPH), and help men over 50 feel stronger and leaner.

 

Some supplements on the market today contain indole-3-carbinol (I3C), a precursor to DIM. However, I3C is unstable and requires activation in the stomach to be converted into DIM. This means I3C must be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach and colon. DIM is by far the preferred supplement.

 

Q. What is saw palmetto? Does it reduce symptoms of Benign Prostate Hyperplasia (BPH)?

A. Yes it does and very effectively too. Saw palmetto is a small palm tree native to Florida and North Carolina. The tree’s dark red berries contain many beneficial compounds. Nutritional supplements that contain saw palmetto are highly effective in the treatment of BPH.

 

The prostate gland is about the size of a walnut and is located below the bladder and in front of the rectum. It wraps around the upper part of the urethra and its primary job is the production and storage of semen, the milky fluid that nourishes sperm. BPH is one of the most common health conditions in older men. Half of all men aged 40-60 and more than 90 percent in men over 80 have BPH. BPH causes the prostate gland to enlarge, putting pressure on the urethra.

 

Men have trouble starting or maintaining a stream of urine, find they can’t completely empty their bladders, and have to urinate frequently, even during the night. They may also have episodes of uncontrollable dribbling or complete loss of urine. BPH is caused by the conversion of estrogen to a very potent form of testosterone called, dihydrotestosterone (or DHT). When prostate cells are exposed to DHT, they multiply in number and get much larger.

 

BPH rarely improves. It most often remains the same for years or gets gradually worse. The need to continually urinate, interrupted sleep, dribbling, and loss of urine can significantly interfere with a man’s quality of life. Prescription medications that have been developed to treat BPH are only partially effective. And surgical removal of the prostate gland may result in even more persistent urinary incontinence and the inability to achieve an erection (ED).

 

However, saw palmetto berry extract relieves the symptoms of BPH by inhibiting the production of DHT. And, in study after study after study, saw palmetto caused none of the side effects that happen with prostate surgery or medications.

 

Q. There seem to be plenty of ads for supplements that claim they make men into Sexual Superheroes. Is there an “honest” nutritional supplement to help me sexually?

A. That’s a very good observation. And yes, there are honest nutritional supplements for men’s sexual health.

 

Sexual intimacy is an important, complex, and lifelong need. It makes us feel better physically and mentally and adds to our sense of security, belonging, and self-esteem. But just like other changes that happen to men as they get older, men’s sexual response most often changes, too. Declining testosterone levels, changes in blood flow to the penis, certain medications that older men are prescribed, and the presence of diabetes or heart disease can all affect men’s ability to engage in sexual activity.

 

When men have a chronic inability in obtaining and/or maintaining an erection, it’s called erectile dysfunction (ED). While ED is not an inevitable part of getting older, it does occur more frequently as men age. About 5% of 40-year-old men have ED, but more than 23% of 65-year-old men have difficulty maintaining erections.

 

The development of prescription medication Viagra (sildenafil citrate) has revolutionized ED treatment. When a man is sexually stimulated, Viagra helps the penis fill with enough blood to cause an erection.

 

Like all medicines, Viagra can cause some side effects, including headache, flushing of the face, and upset stomach. But because Viagra is a prescription medication, it requires a visit to a licensed healthcare practitioner. For many men, telling anyone (even a professional) that they are having trouble getting or keeping an erection is simply too embarrassing. Viagra is also fairly expensive and many older men do not have prescription drug health insurance.

 

These reasons may explain that while an estimated 30 million men in the United States – 10% of the male population – experience chronic ED, as few as 5% of men with chronic ED seek treatment.

 

Not every man can take Viagra, either. Men who use nitrate drugs, often used to control chest pain (also known as angina), must not take Viagra. This combination can cause their blood pressure to drop to an unsafe or life-threatening level. Men with serious liver and kidney problems who take Viagra must be monitored closely for possible serious side effects.

 

The good news is there is a nutritional supplement that’s formulated with vitamins, herbs, and glandular products that targets male sexual organs. The formula contains vitamin E, liver fractions, wheat germ, beta-sitosterol, and herbal extracts of muira puama, Mexican damiana, saw palmetto, cola nut, ginseng, and ginkgo biloba.

 

Vitamin E is a powerful antioxidant and men’s testicles, adrenal glands, and pituitary glands need high levels of this fat-soluble vitamin for proper functioning. Extracts of Muira puama, Mexican damiana, and cola nut have been studied for their beneficial effects on male hormones.

 

Study of ginkgo in sexual response came about when a patient in a nursing home who was taking the herb for memory enhancement noted that his erections were improved. Since then, study of ginkgo has shown it helps blood flow to the penis. Sexual response research in one ginkgo study showed that 76% of men taking ginkgo experienced improved sexual desire, erections, and orgasms.

 

While other nutritional supplements sold to improve sexual stamina often make outrageous claims, reputable manufacturers rely on science and results to sell their products.

 

An important note

Most often sexual problems are simply part of the aging process. They can also be signs of serious health problems. If the use of nutritional supplements for two months does not improve your erections, you do need to see your healthcare practitioner. Almost all practitioners understand how difficult this problem is for men to discuss and are experienced in getting the information as quickly and as painlessly as possible.

 

Conclusion

No man has the power to stop the passage of time. But every man has the power to make aging more healthy and less harmful. Research conducted on men who live to be 100 and beyond, has determined that those who reach extreme old age do so by avoiding ill health, rather than by enduring it. As I like to remind my patients, “Age is not determined by years, but by function.” And it’s never too late for men to detour around the major illnesses of getting older. With good nutrition, healthy habits, and high quality nutritional supplements, the best years of a man’s life can absolutely and positively be those he spends in his 70s, 80s and even his 90s.

 



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Neurological Health and CoQ10
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Date: February 25, 2007 12:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Neurological Health and CoQ10

Between 1946 and 1965, 78 million Americans were born, creating the largest number of children in U.S. history. This Baby Boom generation has greatly influenced the makeup of American society and undoubtedly w ill continue to do so. Thanks to good nutrition and health care, Baby Boomers are aging well and have an excellent life expectancy. For the first time in history, we have more people turning 60 every day, and record numbers of adults reaching their seventh decade. As a result, neurological diseases associated with aging, such as Parkinson’s disease, are becoming major health care concerns. The good news is CoQ10 has applications for neurological diseases, in addition to its better known use for cardiovascular diseases.

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone (existing everywhere there is human life). CoQ10 is vital to the production of adenosine triphosphate (ATP). ATP is the energy-rich compound used for all energy-requiring processes in the body.

Q. Isn’t CoQ10 a supplement for heart health?

A. Yes, it is. Because the heart requires lots of ATP to meet its high energy needs, CoQ10’s function in heart health is well understood. Numerous clinical studies have demonstrated that when individuals with heart disease take CoQ10, their symptoms improve, sometimes quite dramatically. Supplemental CoQ10 improves the heart’s pumping ability, improves blood circulation, increases tolerance to exercise, and improves the heart’s muscle tone. CoQ10 also is a powerful antioxidant and protects heart tissue from free-radical damage.

Q. How does CoQ10 affect brain health?

A. CoQ10 works in the brain the same way it works elsewhere in the body: it’s essential to ATP production. Nearly all human cells contain tiny structures called mitochondria. Mitochondria are referred to as cell powerhouses because they produce cellular energy. Depending on what each cell’s job is. There can be several thousand mitochondria in one cell. If a cell needs a lot of energy, it will have more mitochondria. This explains why heart cells contain so many mitochondria; the continual pumping of blood requires continual ATP production.

The brain also requires huge amounts of uninterrupted energy to regulate, integrate, and coordinate ongoing nervous system transmissions. To meet this need, ATP production within the mitochondria of brain cells is vital. Since CoQ10 exerts such a powerful influence on heart cells in ATP production, it was a natural progression for scientists to wonder how it affects brain cells. Brain and nervous system research led to the conclusion that the same intracellular principles apply. CoQ10 is produced in the body to assist in ATP production. Without it, ATP cannot be produced.

The most important discovery regarding CoQ10 and the brain is that CoQ10, when formulated with certain ingredients, can cross the blood-brain barrier and enter the brain’s mitochondria. If large amounts of CoQ10 can get into the brain cell’s mitochondria, its ability to make ATP is greatly enhanced.

Q. What is the blood-brain barrier and why is it important?

A. The blood-brain barrier is a unique anatomical structure. The cells that make up the blood vessels that provide blood to the brain are extremely close together. This greatly restricts what can leave the bloodstream and enter the brain. While the blood-brain barrier protects the brain and spinal cord from potentially toxic substances, it also can be a significant obstacle to therapy of central nervous system disorders. Only substances with certain solubilities or those that have a transport system can cross the blood-brain barrier to a significant degree.

Obtaining optimal absorption of CoQ10 is difficult. The CoQ10 molecule is large and inflexible. The easiest and least expensive way to increase absorption levels is with the use of harsh solvents such as propylene glycol. However, at higher doses, these types of chemicals are considered dangerous (neurotoxic) to the person with a serious neurodegenerative disease. It is more difficult, as well as more expensive (considering raw materials, research, and proper manufacturing methods) to promote absorption with less harmful alternatives. However, reputable companies ensure that their products are safe for all their customers. Look for CoQ10 products formulated with vitamin E and other safe ingredients such as Micosolle.

Nearly all CoQ10 supplements enter the bloodstream. But, only CoQ10 supplements with special formulations have been scientifically shown to enter the mitochondria and cross the blood-brain barrier.

Q. If CoQ10 is made in the body, why take supplements?

A. While CoQ10 is synthesized in the body, these levels may be insufficient to meet the body’s requirements. Researchers have discovered CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. They also have determined some medications significantly reduce CoQ10 levels in the body.

Although CoQ10 exists in some dietary sources, it may not be realistic to obtain CoQ10 through food alone. For example, it would take approximately 3 pounds of sardines, 7 pounds of beef, or 8 pounds of peanuts to equal 100 mg of supplemental CoQ10.

Q. How does CoQ10 help people with Parkinson’s disease?

A. CoQ10 seems to have several beneficial actions in the illness. Researchers have looked at mitochondria in brain cells and determined people with Parkinson’s disease have reduced activity of Complex I in the electron transport chain. Recent research has proposed the reduced activity of Complex I interferes with the brain-signaling chemical dopamine. Stored and newly synthesized dopamine is depleted. The dopamine depletion causes nerve cell degeneration.

A recent clinical study involved 80 patients with Parkinson’s disease (both men and women). The researchers first evaluated all the participants to establish scores for basic motor skills (measuring the ability to control physical movements such as walking), mental status (whether the person was depressed or experiencing memory loss) and the activities of daily living (whether the person was experiencing difficulty with handwriting, dressing themselves, using utensils such as knives and forks, and so on). This scale is known as the Unified Parkinson’s Disease Rating Scale (UPDRS). This process is known as establishing “baseline values,” that is, the condition of the patient before receiving any treatment.

Participants were divided into 4 groups. Each group received either 300 mg, 600 mg, or 1200 mg of the special form of CoQ10, or a placebo. The researchers observed the participants for 16 months.

The results of the study showed that all the participants who received CoQ10 had smaller declines in function compared to the placebo group, but the smallest decline was experienced by the group taking the highest amount of the special form of CoQ10.

The most significant results were noted specifically in the activities of daily living scores by the people taking 1200 mg of CoQ10 daily. These people retained better ability to feed and dress themselves, speak, walk, and bathe or shower by themselves. They maintained greater independence for a longer time. Parkinson’s disease, as with other neurodegenerative diseases, robs the sufferer of their ability to control the movements of their own body and care for themselves. Supplementation with CoQ10, while not a cure, is the first intervention that showed a slowing in the progressive deterioration of the function associated with this disease.

Q. What were the results of clinical research on Huntington’s Disease?

A. A randomized, double-blind, placebo controlled study respected type of study, was conducted at the University of Rochester. All of the 347 Huntington’s disease (HD) patients were experiencing some HD symptoms, but were still in the early stages of the disease. The patients (who did not know which drug they were receiving) were randomly assigned to four different treatment groups: 25 percent received Remacemide, 25 percent received CoQ10, 25 percent received both, and 25 percent received a placebo, or sugar pill. The researchers, who also did not know which patients got which drug, watched and recorded their progress for two and one-half years. Remacemide is a new drug made by Astra Seneca that blocks the neurotransmitter glutamate in the brain, that has long been suspected of contributing to the death of brain cells in Huntington’s disease.

Unfortunately, in the CARE-HD study, Remacemide had no effect on the progression of the disease in patients in the early stages. However, the individuals who received 600 mg of CoQ10 per day experienced some slowing of the disease progression. They were able to manage daily activities, such as meal preparation, housekeeping tasks, and personal care longer than those not on CoQ10. They were also able to focus their attention better and were less depressed and irritable. The portion of the studied patients receiving 600 mg of CoQ10 per day experienced a 15 percent decline in the progression of HD. According to the researchers conducting the study, a 15 percent decline in the progression of HD would roughly translate into approximately one more year of independence for patients. This is the very first study from more than a dozen Huntington’s disease patient trails that showed any modification of the course of the illness.

Of note, the effects of the CoQ10 had not abated at the end of the research study. That is, the benefit of using CoQ10, 600 mg per day, was still increasing; this suggests that the longer a patient supplements with CoQ10, the greater the decline in the progression of HD. The next phase of the CARE-HD research will test a higher dose of CoQ10 (1200 mg or more per day), with more patients (over 1000), for a longer period of time (approximately 5 years). This study should improve our understanding of the optimal dose and the total achievable decline in the progression of HD. The CoQ10 product used in the CARE-HD study was designated an Orphan Drug by the FDA. The product utilizes a proprietary, patent-pending delivery mechanism, which is proven to be safe and tolerable at high doses for people suffering from neurodegenerative diseases, substantially improving brain tissue levels of CoQ10.

Q. What other diseases could benefit from CoQ10 supplementation?

A. Studies show CoQ10 levels are greatly reduced in Alzheimer’s patients. Mitochondrial abnormalities also are noted; however, research has yet to determine how or why this occurs. Some scientists believe damage to mitochondria is an early feature of the disease. Free-radical damage also is a feature of Alzheimer’s.

In a study of 27 Alzheimer’s patients, subjects were given 60 mg of CoQ10, 150 mg of iron, and 180 mg of vitamin B6 daily. Each patient’s mitochondria activity was effectively activated. All patients continued to experience gradual decline. However, researchers believed that with this combination, the progression was much slower and allowed the patients to experience 1 to 2 years of extended good health.

ALS (also known as Lou Gehrig’s disease) is a progressive, fatal, neurological disease. It occurs when the nerve cells in the brain that control voluntary movement gradually degenerate. Investigation of CoQ10 in individuals with ALS is just beginning. Researchers at the Eleanor and Lou Gehrig ALS Center at Columbia University recently conducted a small clinical pilot trial of CoQ10 in ALS. The study was an open label study, which meant that everyone enrolled received CoQ10, 400 mg three times per day. Of the 16 patients originally enrolled, nine patients completed the study. Six of these nine patients experienced some benefits. The patients declined from 0 – 25 percent in functional scores, 6 percent in strength, and 10 percent in breathing ability. These scores reflect a positive trend compared to the 50 percent decline that is seen in the natural history of ALS over the same period of time (5 to 9 months). Citing the need to conduct more studies of the effectiveness of CoQ10 for people with ALS is rapidly and efficiently as possible to get answers to patients and clinicians, another clinical trial is currently underway at the Gehrig ALS Center. This is a pilot study to determine if CoQ10 has short-term effects on motor nerves in the brain using magnetic resonance spectroscopy (MRS). The researchers are going to try to “see” if CoQ10 can change the chemical sin the brain’s upper motor nerves of people with ALS, an important next step of the investigation.

Q. Can taking CoQ10 prevent neurodegenerative disease?

A. To date, there have been no studies or research examining whether CoQ10 can prevent these diseases.

Alzheimer’s disease prevention is being clinically investigated. Researchers have determined that people who take certain anti-inflammatory medications seem less likely to develop the illness. A large, multi-centered trial is studying this connection.

Q. How much CoQ10 should I take?

A. Depending on your family history of neurological disease and your disease experience, studies show benefits at doses of 100 to 200 mg of CoQ10 daily. Some studies used doses of up to 1,200 mg per day.

CoQ10’s safety has been evaluated. To date, no toxicities have been reported. Mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.

Q. What should I look for in a CoQ10 supplement?

A. Use products which have a strong clinical research track record, supported by product-specific research from reputable institutions, and have been proven to be safe, tolerable and effective in treatment of neurodegenerative diseases. The CoQ10 product you choose should be proven to: be absorbed, enter the blood stream, cross the blood brain barrier and increase mitochondrial levels of CoQ10. If the product you are considering does not have evidence to support these points, keep looking. Once you have found a candidate, examine the product’s safety and efficacy record for neurodegenerative diseases- if the product has not been proven to be safe and effective, keep looking. Good products exist; however, caveat emptor.

Conclusion

CoQ10 supplementation for people with neurodegenerative diseases is supported by contemporary clinical research. CoQ10 is certainly not the only answer to the complex issues of management and treatment of these types of diseases. However, research indicates that it is a bigger piece of the puzzle than physicians and scientists ever imagined. As we continue to study this naturally occurring compound, we are finding more and more benefits to the body.

All CoQ10 is not created equal. For safety and overall effectiveness, use a CoQ10 product that is supported by product-specific research from reputable institution, which is proven to be safe, tolerable and effective at high doses; deviating from this set of criteria may do more harm than good for people with these serious illnesses. Choose clinically tested products from a well-respected company and increase the potential to achieve and maintain brain and neurological health.



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Fruit and Vegetable Lightning drink mixes from Natures Plus
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Date: February 06, 2007 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fruit and Vegetable Lightning drink mixes from Natures Plus

Enjoy the Rainbow – the Color Wheel of Fruits and Vegetables

 

We’ve all heard the statistics, and have probably seen the signs in the produce section of our favorite grocery store: eating 5 servings of fruits and veggies a day is important,

 

Chances are also pretty good that we’ve also seen the newest food pyramid, encouraging Americans to “eat a rainbow of frits and vegetables.” That is, choose from the rich variety of colors for the best all-around health benefits.

 

In this Ask the Doctor, we’re going to look at the unique health components of different colored fruits and vegetables, and why they’re so important. Plus, we’ll learn about supplemental options, like fruit and vegetable drink mixes, for those days when our diets just aren’t that great.

 

Q. What’s the big deal about fruits and vegetables?

A. Well, for the main reason that they are whole foods – created by nature (or at least generations of farming) and are rich in a variety of nutrients. Processed foods can’t match the health benefits of strawberries or broccoli – items that have fiber, vitamins, and enzymes built right in.

 

Q. What does “eating a rainbow” of fruits and vegetables really mean?

A. This is simply an easy way of remembering to get as much color variety in your diet as possible to maximize your intake of a broad range of nutrients. The colors of fruits and vegetables are often a tangible clue to the unique vitamins and other healthy substances they contain. Getting a variety of colors, therefore, means getting a variety of the essential nutrients your body needs to stay healthy and strong.

 

Enjoying the Rainbow: Fruit and Vegetable Benefits:

Color

Source

Nutrients

Benefits

Red

Tomatoes, Berries, Peppers, Radishes

Lycopene, Anthocyanins, Ellagic Acid, Bioflavonoids including Quercetin, and Hesperidin

Reduces risk of prostate cancer; lowers blood pressure; scavenges harmful free-radicals; reduces tumor growth; reduces LDL cholesterol levels and supports joint tissue in cases of rheumatoid arthritis

Orange/ Yellow

Carrots, Yams, Squash, Papaya

Beta-carotene, Zeaxanthin, Flavonoids, Lycopene, Vitamin C, Potassium

Reduces age-related macular degeneration; lowers LDL (bad) cholesterol; fights harmful free radicals; reduces risk of prostate cancer, lowers blood pressure; promotes collagen formation and healthy joints; encourages alkaline balance and works with magnesium and calcium to build healthy bones

White

Mushrooms, White Tea, Flaxseed/ Pumpkin

Beta-glucan, EGCG (epigallocatechin gallate), SDG (secoisolariciresinol digulcoside), lignans

Provides powerful immune boosting activity; activates natural-killer cells, B-cells and T-cells; may reduce risk of colon, breast and prostate cancers; boosts immune-supporting T-cell activity; balances hormone levels and may reduce risk of hormone-related cancers

Green

Wheat Grass, Barley Grass, Oat Grass, Kale, Spinach, Cabbage, Alfalfa Sprouts, Mustard Greens, Collard Greens

Chlorophyll, Fiber, Lutein, Zeaxanthin, Calcium, Folate, Glucoraphanin, Vitamin C, Calcium, Beta-Carotene

Reduces cancer risks; lowers blood pressure; normalizes digestion time; supports retinal health and reduces risk of cataracts; builds and maintains bone matrix; fights harmful free-radicals; boosts immune system activity; supports vision and lowers LDL cholesterol levels

Purple/ Blue

Blueberries, Pomegranates, Grapes, Elderberries, Eggplant, Prunes

Anthocyanins, Lutein, Zeaxanthin, Resveratrol, Vitamin C, Fiber, Flavonoids, ellagic acid, quercetin

May protect brain cells against Alzheimer’s and other oxidative-related diseases; supports retinal health; lowers LDL cholesterol and prevents LDL oxidation; boosts immune system activity and supports healthy collagen and joint tissue; supports healthy digestion; improves calcium and other mineral absorption; fights inflammation; reduces tumor growth; acts as an anticarcinogen in the digestive tract, limits the activity of cancer cells –depriving them of fuel; helps the body fight allergens

 

Q. Can you tell me a little more about the healthy components of fruits and vegetables?

Let’s take a look at some of the most well-studied and important nutrients:

 

Quercetin is found in apples, onions and citrus fruits (also is hawthorn and other berries and apple-related fruits usually used in traditional herbal remedies and modern supplements). It prevents LSL cholesterol oxidation and helps the body cope with allergens and other lung and breathing problems.

 

Clinical studies show that quercetin’s main points of absorption in the body appear to be in the small intestine – about 50%. The rest – at least 47% is metabolized by the colonic micro flora – the beneficial bacteria such as Lactobacillus acidophilus and Bifidobacterium longum. You may consider adding these beneficial bacteria (found in yogurt) either through the diet or a supplemental form.

 

Ellagic Acid is a component of ellagitannins – dietary polyphenols with antioxidant (and possibly anticancer) properties. Polyphenols are the basic building blocks of many plant-based antioxidants. More complex phenolic compounds, such as flavonoids are created from these molecules.

 

Ellagic acid is found in many fruits and foods, namely raspberries, strawberries, pomegranates, and walnuts. Clinical studies suggest that ellagitannins and ellagic acid act as antioxidants and anticarcinogens in the gastrointestinal tract.

 

Ellagitannins are durable antioxidants, and happily, they do not appear to be diminished by processing, like freezing. This means the benefits are still strong, even in frozen packs of raspberries or strawberries, or some of the better multi-ingredient supplement drink mixes.

 

In scientific studies, ellagic acid also showed an anti-proliferative effect on cancer cells, decreasing their ATP (adenosine triphosphate) production. ATP is the molecule that provides the primary energy source for the cells in our bodies. In a sense, ellagic acid seems to deprive cancer cells of their fuel.

 

Beta-Carotene: Probably the best-known of the carotenoids, beta-carotene is converted by the body into vitamin A. Many vegetables, especially orange and yellow varieties, are rich in this nutrient. Think summer squash, yams and of course, carrots.

 

Beta-carotene has long been associated with better eyesight, but it has other benefits, too. In a scientific study, beta-carotene decreased cholesterol levels in the liver by 44% and reduces liver triglycerides by 40%.

 

Lycopene is a carotenoid mostly found in tomatoes, but also in smaller amounts in watermelon and other fruits. Clinical studies have shown that lycopene consumption may decrease the risk of prostate cancer. In fact, high intakes of lycopene are associated with a 30% to 40% reduced risk. And, as good as beta-carotene is, its cousin, lycopene, seems to be an even stronger nutrient, protecting not just against prostate cancer, but heart disease as well.

 

Lutein is found in many fruits and vegetables, including blueberries and members of the squash family. Lutein is important for healthy eyes, and in fact it is found in high concentrations naturally in the macular region of the retina – where we see fine detail. It is one of the only carotenoids, along with its close sibling zeaxanthin, that is found in the macula and lens of the eye.

 

Lutein also supports your heart, too. In a scientific study, lutein reduced atherosclerotic lesion size by 43%. In other words, high intakes of lutein may actually help prevent coronary artery disease!

 

Interestingly, as is the case with lycopene, cooking or processing foods with lutein may actually make it more easily absorbed.

 

In clinical studies, men with high intakes of lutein (and its close cousin, zeaxanthin, found in broccoli and spinach) had a 19% lower risk of cataract, and women had a 22% decreased risk, compared to those whose lutein intakes were much lower.

 

Vitamin C: One of the best-known nutrients out there, vitamin C keeps our immune system strong; speeds wound healing, and promote strong muscles and joints. A free-radical fighter, vitamin C prevents oxidative damage to tissues, builds strength in collagen and connective tissue, and even reduces joint pain.

 

Sources of vitamin C are scattered throughout the spectrum of fruits and vegetables. Oranges and other citrus are the most commonly associated with vitamin C, but it also is present in tomatoes, and to a lesser extent in berries and cherries.

 

Potassium: Most Americans are deficient in potassium. For the most part, it’s hard to get too much of this valuable mineral. Potassium does great things for our hearts. Higher intakes of dietary potassium from fruits and vegetables have been found in clinical research to lower blood pressure in only 4 weeks.

 

Many researchers believe that the typical American diet has led to a state of chronic, low-grade acidosis – too much acid in the body. Potassium helps change pH balance to a more alkaline environment in the body and increases bone density.

 

This was proven in the long-running Framingham Heart Study which showed that dietary potassium, (along with magnesium and fruit and vegetable intake) provided greater bone density in older individuals.

 

Fiber is another food component many just don’t get enough of – especially if they’re eating a “typical American diet.” Fruits, vegetables and whole grains are excellent sources of fiber. However, fiber from a good fruits and vegetable drink mix should be derived from inulin and chicory root. This soluble fiber source not only adds to the overall amount of fiber you need (25 to 38 grams a day), but also provides a nice “nesting ground” for the beneficial bacteria that populate the intestines. And, even though some fiber has a bad rap for inhibiting mineral absorption, inulin and chicory root are “bone building” fibers – they actually help the body absorb calcium.

 

Flavonoids are an overarching term that encompasses flavonols, anthocyanidins, and flavones, isoflavones, proanthocyanidins, Quercetin and more. They are almost everywhere: in fruits, vegetables, grains, herbs, nuts and seeds – even in the coffee, wine and tea we drink. Flavonoids are responsible for the colors in the skins of fruits and the leaves of trees and other plants.

 

Flavonoids have many health benefits. They can help stop the growth of tumor cells and are potent antioxidants. Additionally, flavonoids have also been studied for their ability to reduce inflammation.

 

Anthocyanins: High on the list of important “visible” nutrients are anthocyanins. They color fruits and vegetables blue and red.

 

Anthocyanins are members of this extended family of nutmeats, the flavonoids. Typically found in high amounts in berries, anthocyanins are readily absorbed in the stomach and small intestine.

 

As antioxidants, anthocyanins dive deep into cell membranes, protecting them from damage. IT may be one reason why the anthocyanins from blueberries are considered such an important component in battling neuronal decline, like Alzheimer’s. Blackberries, raspberries, and strawberries are also excellent sources of this flavonoids group.

 

SDG lignans, (short for secoisolariciresinol diglucoside) are polyphenolic components of flaxseed, pumpkin and other herbal sources. Much of the recent research surrounding lignans has focused on flaxseed. In scientific and clinical studies, lignans from flaxseed support hormonal balance and may have cancer-preventing abilities. In fact, in one study, flaxseed lignans reduced metastatic lung tumor by 82% compared to controls.

 

The lignans in pumpkin seed, also considered a major source, target 5-alpha reductase activity.

 

This enzyme catalyzes the conversion of testosterone into the more potent dihydrotestosterone (DHT). DHT, like testosterone, is a steroid hormone or androgen. Androgens are responsible for the development and maintenance of masculine sex characteristics in both men and women. Excess levels of DHT can cause serious problems with prostate or bladder health. That’s why modulation of the 5-alpha reductase enzyme is so important – it helps maintain healthy testosterone and DHT levels. By balancing the levels of these key hormones, pumpkin seed lignans provide protection for prostate and bladder cells.

 

In addition, pumpkin seed has been shown to modulate the enzyme aromatase. Aromatase is present in the estrogen-producing cells of the adrenal glands, ovaries, testicles, adipose tissue, and brain. Aromatase converts testosterone, an androgen, into estradiol, and estrogen.

 

Inhibition of the aromatase conversion can help maintain a balance of healthy testosterone levels in women, which has been shown to strengthen pelvic muscles and reduce incidence of incontinence.

 

In fact, a clinical study, involving a pumpkin extract in conjunction with soy, resulted in significant support for bladder health. After two weeks of supplementation, 23 of the 39 postmenopausal women enrolled in the study showed great improvement in urinary frequency and sleep. By the end of the six week study, 74.4 percent of participants found pumpkin extract safely and significantly improved “nocturnia,” that is, the need to urinate frequently at night. For individuals with 2 to 4 episodes of nocturnia prior to the stud, and 81.8% improvement was seen – also showing great improvement in sleep quality. After all, if you don’t have to wake up every couple of hours to go to the bathroom you’re bound to get better sleep.

 

Beta glucan: Mushrooms are intense immune-boosting powerhouses due to their beta-glucan content. Three well-studied power-house mushrooms that contribute beta glucan to the diet include maitake, reishi and shiitake.

 

The most significant constituents of mushrooms are long chain polysaccharides (molecules formed from many sugar units) known as beta-glucan. These huge molecules act as immunoregualtors in the human body, helping to stabilize and balance the immune system.

 

This includes specific support of white blood cells, or lymphocytes, the primary cells of the immune system. Lymphocytes fall broadly into three categories: T cells, B cells, and natural killer (NK) cells.

 

In one clinical study, 165 patients with various types of advanced cancer were given maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, and 62% of lung cancer patients. Plus, when maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.

 

In another clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.

 

And, in a scientific study of human breast cancer and myeloma cancer and myeloma cancer cell lines, shiitake compounds provided a 51% antiproliferative effect on the cells – inducing “apoptosis’ – the programmed cell death that should occur naturally.

 

While beta-glucan are distributed throughout the mushroom body, the beta-glucan concentrations are significantly higher in the mycelium – the interwoven fibers or filaments that make up the “feeding structure” of the mushroom.

 

Bioflavonoids are commonly found in bright yellow citrus fruits, including lemons, limes and oranges. They are responsible for the bright pigment found in the skin of the fruit, and are considered a “companion” to vitamin C, seeming to extend the value of the nutrient within the body.

 

Hesperidin is just one of the valuable bioflavonoids found in citrus. Hesperidin appears to lower cholesterol levels, as well as support joint collagen in examples of rheumatoid arthritis.

 

Epigallocatechin gallate (EGCG):

Polyphenols, most notably EGCG, or epigallocatechin gallate, are well-studied and powerful components of tea. EGCG has been shown to reduce colon and breast cancer risk. Green tea also boosts the immune system and encourages T-cell formation – part of the front-line defense of our bodies against sickness and disease.

 

Q. I’ve been seeing articles about fruits, vegetables and supplements touting “high ORAC value.” What does this mean?

ORAC is an acronym for Oxygen Radical Absorption Capacity, and is simply a measurement of antioxidant activity of nutrients. Oxygen radicals, or free radicals, are unstable molecules. They grab electrons from other cells to use for themselves, and in the process can damage them. It is believed that free radical activity plays a role in the development of many diseases such as heart disease and cancer, and also plays a role in aging.

 

Antioxidants help prevent this damage by “loaning out” extra electrons to stabilize free radicals/ Consider any fruit or vegetable with a high ORAC rating as having a lot of “antioxidant power.”

 

I know I should eat more fruits and vegetables, but it just seems so hard to get five servings a day.

The number one excuse I hear for not buying frits and veggies is that “fruits and vegetables are too expensive.” But are they really? Certainly, fresh foods that aren’t in season and have to be shipped a distance can be a bit pricey. If anyone added up how much spend on fast food, or prepackaged or processed snacks, it would probably be shocking.

 

Luckily, there are many ways to get your “Daily 5”. For instance, frozen fruits and veggies retain much of their nutrient profile. They can be an excellent alternative when certain foods are out of season. So too, are fruit and vegetable drink mixes – excellent supplemental sources of some of the nutrients our bodies need most.

 

More recently, the American Institute of Cancer Research discovered a reason many adults don’t eat their vegetables is – I’m not making this up – “a fear of flatulence.”

 

Of course, for people not accustomed to the fiber in fruits and veggies, there is some reason to think it’ll increase gas. When cell walls break down, and fiber passes through the system, it can create flatulence. Folks who eat fruits and vegetables every day generally don’t have this problem. Their systems are already accustomed to it.

 

For those just starting out on a better diet, however, start slowly – it helps your body adapt. Cooking vegetables can help, too, because it begins breaking down the cell walls early on.

 

One thing is certain, however. The “Typical American Diet” and good health are mutually exclusive. The increase in type 2 diabetes, heart disease, high cholesterol, and hypertension all point to the abuse our bodies suffer by eating diets high in fatty meats, processed sugars, and refined grains.

 

Q. Can I just drink fruit and vegetables drinks in place of 5 servings of fruits and vegetables?

Green drinks and fruit and vegetable drink mixes aren’t meant to replace whole foods, but they can be an excellent substitute when you’re rushed or traveling or just trying to fill everyday nutritional gaps. Their whole food ingredients absorb very easily and gently in the gut, and many of these drink mixes contain healthy doses of fiber, too.

 

Green drink mixes and food-based drink mixes combine many colorful fruits and vegetables and sometimes grasses in a healthy, mixable supplement assortment. While there have been many advancements in the field of green drinks, there are only a few that take the primary reason we eat into consideration: taste!

 

Happily, there are some companies out there with great-tasting drink mixes that also formulate based on the color concept, ensuring you get the broadest assortment of nutrients from a full range of fruit and vegetable colors to promote optimal health.

 

High-quality fruit and vegetable drink mixes offer the best from nature’s color wheel in a convenient and great-tasting supplement. So, the next tie you feel like taking a coffee break – try a fruit and veggie break instead. Your body and spirit will thank you.

 

 



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Mushrooms are good for the Immune System
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Date: January 26, 2007 06:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mushrooms are good for the Immune System

Medicinal Mushrooms Grown on Purple Kculli Corn Yield Life Changing Results

Even though we treat them like vegetables, mushrooms aren’t really plants. They’re fungi and fungi grow much differently than fruits and vegetables. Most food plants, like strawberries, broccoli, and red bell peppers make chlorophyll from sunlight to gain the nutrients they need to grow. Mushrooms don’t make chlorophyll; to get the nutrients they need to grow, mushrooms release enzymes into the forest floor or flora they’re living on to break down the organic matter into a form the mushroom can absorb.

Because most mushrooms that we eat or use today are raised as crops, or cultivated, they are grown on a variety of substrates. Similar to the commercial potting soils you can buy at nurseries and garden stores, mushroom substrates vary widely in quality and the kinds of nutrients within. Mushrooms are really unique in that they can grow on almost anything, such as sawdust, shredded newspaper, and straw.

However, mushrooms are only as nutritious as the substrate they were grown on-even those unique varieties called medicinal mushrooms. While the simple button mushrooms found on pizza are most often eaten for their woodsy taste and texture, the use of medicinal mushrooms is much more complex. These mushrooms are valued because they contain numerous compounds that have been extensively studies by researchers for their ability to activate cells of the immune system.

Researchers have recently discovered that when medicinal mushrooms are grown on a Purple Kculli (pronounced ka-coo-lee) Corn substrate, the resulting mushrooms are jam-packed with powerful and potent disease-fighting compounds. Beautiful Purple Kculli Corn has long been used by the people of the Peruvian Andes as a tasty vegetable, natural food color, and powerful functional food-keeping them healthy and free of disease.

In this issue of Ask the Medicine Hunter, we’re going to talk about four powerful medicinal mushrooms that, when grown on Purple Kculli Corn, have even more potent compounds to prevent and treat cancer and other serious health problems.

Q. How exactly do medicinal mushrooms prevent and treat cancer?

A. Medicinal mushrooms are very complex. They contain numerous compounds that have been extensively studied for their ability to activate cells of the immune system. Some of the most amazing immune boosting compounds in medicinal mushrooms are beta-glucans 1-3, beta glucans 1-6, arabinogalactins, and arabinoxylans – compounds that work “hand-in-hand” with certain cells of the immune system. But to get abundant amounts of these compounds, medicinal mushrooms must be grown on substrates with high levels of nutrients. And the most nutrient dense substrate of all comes from Purple Kculli Corn.

Q. Why is Purple Kculli Corn extract good for growing medicinal mushrooms?

A. You’ve probably heard that brightly colored fruits and vegetables (like beets, broccoli, and blueberries), have more antioxidant power than paler fruits and vegetables (like iceberg lettuce, onions, and garlic). In fact, the deeper the color, the better. And there is no deeper color in nature than the deep purple of Purple Kculli Corn grown in the lush coastal plains of Peru. The kernels from Purple Kculli Corn are not only naturally beautiful, the pigment itself is extremely healthy and have been used by the people of the Peruvian Andes for centuries as both food and food coloring.

Once harvested, the Purple Kculli Corn is naturally processed into an antioxidant-rich extract. When certain medicinal mushrooms are grown on Purple Kculli Corn extract, the Purple Kculli Corn becomes a super-substrate, producing medicinal mushrooms with incredible amounts of the immune-boosting compounds. And when Purple Kculli Corn extract is added to medicinal mushroom formulas the antioxidant power increases, too.

Q. How do the medicinal mushroom compounds fight disease?

A. When bacteria, viruses, or other pathogens are present in the body, white blood cells, or leukocytes, swing into action. Leukocytes work together to defend the body against infections, like colds or the flu, as well as diseases that start within us, like cancer. These disease fighting cells are the backbone of the body’s defense system. And each type of cell works in different ways.

The macrophage, a name that means “big eater,” is a first-strike leukocyte that protects us from disease by, quit literally, devouring invading pathogens. Natural Killer (NK) cells act like sentries – constantly prowling for cancer cells, killing them quickly when they’re discovered. B-cells are the immune system’s military intelligence, seeking out targets and communicating their coordinates, while T-cells are the foot soldiers, destroying the invaders that the intelligence system has identified.

Scientists have long known that medicinal mushrooms help make white blood cells more deadly. But until recently, they weren’t sure how. Research has now shown that macrophages and NK cells have receptor sites specifically for beta-glucans 1-3 and beta-glucans 1-6. When the beta-glucans bind to the macrophages and NK cells, they make the lymphocytes stronger and more lethal. By increasing the lymphocytes’ strength, beta-glucans help them churn out more of the specialized chemical messengers, too.

Arabinogalactins and arabinoxylans, powerful polysaccharides found in medicinal mushrooms, are potent stimulators of the immune system. These compounds increase the activity of interleukins, interferons, and a tumor necrosis factor, all key components in a healthy immune system. When medicinal mushroom extracts with high amounts of Arabinogalactins and arabinoxylans are taken, diseases are dramatically reduced.

Researchers found that complex polysaccharides in four varieties of medicinal mushrooms – Agaricus blazei (Agaricus), Grifola frondosa (Maitake), Coriolus versicolor (Coriolus or Turkey Tail), and Ganoderma lucidum (Reishi) – are serious cancer fighters. The chart below explains how:

Mushroom Health Benefit

Agaricus (Agaricus Blazei)

Agaricus not only contains the greatest number of medicinal compounds, it also contains a powerful anti-tumor polysaccharide that all other medicinal mushrooms are lacking. Recently, 100 women who were receiving carboplatin, a chemotherapy drug used to treat ovarian cancer, volunteered for an important study. Half of the women were given an extract of Agaricus mushrooms, while the other half were given a placebo or dummy pill. The researchers discovered that NK cell activity was significantly higher in the Agaricus group. The women in this group were also less nauseated, fatigued, and wear than the women taking the placebo, an important consideration for people with cancer.

Maitake (Grifola Frondosa)

Maitake is one of the most researched of all medicinal mushrooms. In one clinical study, the effect of Maitake mushroom compounds were studied in ten patients with cancer who were not currently taking any chemotherapeutic drugs. The researchers found that the Maitake not only significantly stimulated NK cell activity, it also repressed the cancer’s growth, and stopped the tumors’ ability to metastasize, or spread to other parts of the body. And in another clinical study, 165 patients with various types of advanced cancer were given Maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, 69% of breast cancer patients, and 62% of lung cancer patients. Plus, when Maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.

Coriolus(Coriolus Versicolor)

Versicolor compounds show great promise as cancer immunotherapy agents in all cancer stages. In one clinical trial, 34 patients with advanced terminal lung cancer were given Coriolus versicolor polysaccharides or a placebo (dummy pill) for 28 days. While the group getting the Versicolor felt less fatigued and sick, very important considerations at the end-of-life, there were no changes in the placebo group.

Reishi (Ganoderma Lucidum)

Reishi mushrooms are too tough to eat, but they’ve been used medicinally for centuries and have been extensively researched. In a safety study to determine Reishi’s effect on blood thinning mechanisms, healthy volunteers received 1.5 gm Reishi or placebo daily for 4 weeks. There were no significant changes in either group and all blood clotting measurements remained within the normal range, demonstrating its safety. In a recent clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.

Not only do Agaricus, Maitake, Coriolus, and Reishi have incredible amounts of immune boosting polysaccharides, when they are grown on Purple Kculli Corn, they also have a much higher ORAC value than mushrooms grown on other substrates.

Q. What are ORAC values?

A. ORAC, or Oxygen Radical Absorbance Capacity, is a measurement of the antioxidant power in fruits and vegetables. The higher the power, or ORAC value, the stronger the antioxidant is against free radicals. While free radicals are made by breathing oxygen and digesting food, and are simply the consequences of being alive, the older we get the more free radicals we make. And the more free radicals we make the more destructive they can be. Free radicals will rip membranes, wreck cells, cripple mitochondria, and ruin DNA. As this damage accumulates, even more free radicals are made. And if not stopped or slowed, this might lead to heart disease, arthritis, diabetes, dementia, and cancer.

Q. How does Purple Kculli Corn increase the ORAC value of medicinal mushrooms?

A. All brightly colored fruits and vegetables have very high ORAC values; and the higher the ORAC value – the greater the antioxidant power. Not only can we measure the ORAC values of fruits and vegetables, we can also measure the ORAC values of mushroom substrate extracts. Purple Kculli Corn extract has an ORAC value of 1789 (measured in umolesTE/gram). Now, remember that mushrooms are fungi, not fruits and vegetables, and they gain most of their nutrients from the ground (or substrate) they are grown on. When mushrooms are cultivated or “farmed” on substrates with a high ORAC value, they will absorb compounds from the substrate giving them a higher ORAC value, too. So growing mushrooms on antioxidant rich, high ORAC value, Purple Kculli Corn yields medicinal mushrooms with high ORAC values as well.

Q. Some mushroom supplements have more than four medicinal mushrooms. Wouldn’t a mushroom supplement with seven mushrooms or more have a higher ORAC value than a supplement with only four?

A. Well, more is not always better – especially when it comes to medicinal mushrooms. Some supplements have a “kitchen sink” selection of mushrooms. The makers of these supplements hope that by adding modest amounts of many mushrooms, they will end up with a product that just might have some health benefits.

Clearly, it’s not how many or how exotic the mushrooms are in a medicinal mushroom supplement, it’s the substrate that mushrooms are grown on that makes the difference.

Q. How can I make sure the medicinal mushroom supplement I buy contains natural and organic mushrooms grown on Purple Kculli Corn substrate?

A. Become a label reader! Medicinal mushroom formulas have a statement showing accreditation from a certifying agency, such as the American Food Safety Institute, International; California Organic Farmer Association, Minnesota; or Crop Improvement Association, on the label, and have met certain criteria. They must be grown without chemicals or pesticides. The growers must be certified as organic mushroom produces by an accredited third party. And the growers must keep a record of their production and handling practices.

Conclusion

Of the nearly 38,000 varieties of mushrooms, Agaricus blazei, Grifola frondosa, Coriolus versicolor, and Ganoderma lucidum have impressive medicinal properties. With a little help from Purple Kculli Corn, these mushrooms can provide even more potent and powerful cancer preventing properties for superior mushroom supplements.



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Benefits of L-Carnitine
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Date: February 12, 2006 03:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of L-Carnitine

Benefits

Helps the body burn fat for energy*

L-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion. Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine. The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body's L-Carnitine content is stored in the form of acyl-carnitine.1

The mitochondrion is the cell’s energy-generating furnace. Called an “organelle,” the mitochondrion is a self-contained structure inside the cell. Like all cellular structures, the mitochondrion is surrounded by a membrane. This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter. On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation. One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.” L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.

Evidence suggests that L-Carnitine and short chain acyl-carnitine esters can protect the mitochondrion from adverse effects of drugs and toxic chemicals. L-Carnitine has been shown to protect animals form cardiotoxins and decrease mortality rate in animals with diphtheria, due to this cardioprotective effect.2

Helps maintain a healthy heart and cardiovascular system*

Muscle tissue contains a high concentration of L-Carnitine. With its constant energy needs, heart muscle tissue is especially rich in L-Carnitine. If the body’s ability to biosynthesize L-Carnitine is compromised, energy production in muscle tissue is impaired, and a toxic buildup of fatty acids can occur.3 Defective production of L-Carnitine by the body can result from a variety of factors, including kidney or liver malfunction, increased catabolism or the inability of tissues to extract and retain L-Carnitine from the blood.

Along with glucose and lactate, fatty acids are the primary oxidation fuel for the heart. A considerable amount of scientific data from animal experiments indicates that L-Carnitine protects the heart under conditions of hypoxia, or low oxygen. In addition to the oxidation of fat for energy in the cell, L-Carnitine is involved in the metabolism of glucose.4 Evidence of L-Carnitine’s role in glucose metabolism was uncovered in a small trial on 9 diabetic individuals. Given intravenously, L-Carnitine improved insulin-mediated glucose utilization and insulin sensitivity.5

Depletion of the body’s L-Carnitine supply is linked to various abnormal states, especially of the heart muscle. The effect of L-Carnitine on hypoxic (oxygen-starved) isolated heart muscle tissue has been studied.6 At high concentrations, L-Carnitine demonstrates a clear-cut ability to potentiate the contractility of isolated heart muscle tissue, indicating the L-Carnitine has a strengthening effect on the heart. L-Carnitine has been shown to improve the performance of rats subjected to fatigue test.

Research has revealed that in animals and humans with defective heart muscle, the amount of free L-Carnitine (not bound to fatty acids) is reduced. Administration of L-Carnitine to hamsters prevents damage to the heart muscle. Given to humans with angina, L-Carnitine was found to improve exercise tolerance. In a small study, patients with congestive heart failure showed gains in heart function with oral consumption of L-Carnitine, reportedly by restoring normal oxidation of fatty acids.7 In heart valve replacement patients, L-Carnitine has been shown to increase the valve tissue levels of ATP, pyruvate and creatine phosphate, which are key cellular energy substrates. In a controlled study, L-Carnitine was administered to 38 patients prior to open heart surgery. Prior to surgery, heart circulatory function, as assessed by measurements of hemodynamics, was “good” in all 38. While there was evidence of a “preserving” effect of L-Carnitine on heart cells, no differences in cardiac performance were observed. These results suggest that noticeable improvements in heart muscle performance with L-Carnitine are most likely to occur in people with compromised hearts.8

It has been suggested that L-Carnitine favorably influences blood lipids. Preliminary evidence of this was seen in a small open trial on 26 patients who took 3 grams of L-Carnitine daily for 40 days. Blood levels of cholesterol and triglycerides dropped substantially, while the ratio of total to HDL cholesterol–– a known marker of cardiovascular health––markedly improved.9

While L-Carnitine is not a treatment for heart disease, (nor should it be used as a substitute for medical treatment) the results of these and other studies suggest that oral consumption of L-Carnitine has a beneficial influence on maintaining a healthy heart and cardiovascular system.



Safety

Suggested Adult Use: Take 1 to 4 capsules daily without food.

L-Carnitine is considered to be very safe for oral consumption. L-Carnitine is generally well tolerated, even at doses as high as 15 grams daily. Toxicity or overdosage has not been reported.10



Scientific References
1. Wagenmakers, A. L-Carnitine supplementation and performance in man. Brouns, F. ed. Advances in Nutrition and Top Sport. Med Sport Sci. Basel, Karger, 1991;32:110-27.
2. Arrigoni-Martelli, E., Caso, V. Carnitine protects mitochondria and removes toxic acyls from xenobiotics. Drugs Exptl. Clin. Res. 2001;27(1):27-49)
3. Pepine, C.J. The therapeutic potential of carnitine in cardiovascular disorders. Clinical Therapeutics 1991;13(1):2-21.
4. Calvani, M., Reda, E., Arrigoni-Martelli, E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Research in Cardiology 2000;95(2):75-83.
5. Capaldo, B. et al. Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients. Diabetes Research and Clinical Practice 1991;14:191-96.
6. Fanelli, O. Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties. Life Sciences 1978;23:2563-2570.
7. Kobayashi, A., Masumura, Y., Yamazaki, N. L-Carnitine treatment for congestive heart failure-experimental and clinical study. Japanese Circulation Journal 1992;56:86-94.
8. Pastoris, O. et al. Effect of L-Carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing heart surgery. Pharmacological Research 1998;37(2):115-22.
9. Pola, P. et al. Carnitine in the therapy of dyslipidemic patients. Current Therapeutic Research 1980;27(2):208-16.
10. L-Carnitine. PDR for Nutritional Supplements. First Ed. 2001.Montvale, NJ:Medical Economics.



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Benefits of Acetyl-L-Carnitine
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Date: February 12, 2006 01:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Acetyl-L-Carnitine

Benefits

Supports cognitive function*

ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days.2 Hospitalized elderly people taking ALC have shown improvements in mental outlook.3 While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5

Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve function* Brain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC.6 It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine.7 ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.8

Helps supply the brain with energy by improving energetics in the mitochondrion*

The acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. 9 Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.10

Stabilizes intracellular membranes*

ALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients.11 Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes.12 ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.13

Increases nerve growth factor production*

The body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes.14 Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF.15 These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.16

Has a protective influence on brain neurons*

Several animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC.17 Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+.18 ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue.19 ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation.20 ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.21 As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption.


Safety
Suggested Adult Use: 1 to 4 capsules daily.
ALC is considered safe and well-tolerated when consumed orally. ALC has been administered in doses as high as 3 grams per day for periods of two to six months, with no reports of serious side effects. Some patients have experienced occasional mild abdominal discomfort, nausea, skin rash, restlessness, vertigo and headache. The severity and incidence of these side effects are reported as minor.22

Scientific References
1. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
2. Salvioli, G. Neri , M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exptl. Clin. Res. 1994; 20(4):169-76.
3. Tempesta, E, et al. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs. placebo. Drugs Exptl. Clin. Res. 1987;8(7):417-23.
4. Spagnoli, A et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 1991;41:1726-32.
5. Rai, G et al. Double-blind, placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia. Curr. Med Res. Opin. 1990;11:638-47.
6. Falchetto, S, Kato, G, Provini, L. The action of carnitines on cortical neurons. Can J Physiol Pharmacol 1971; 49(1):1:7.
7. Dolezal, V., Tucek, S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 1981;36(4):1323.30.
8. Passeri, M, et al. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. Int. J. Clin. Pharm. Res. 1988;8(5):367-76.
9. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
10. Parnetti, L, et al. Pharmacokinetics of IV and oral acetyl-L-carnitine in multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin Pharmacol 1992;42:89-93.
11. Pettegrew, JW, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiology of Aging 1995;16(1):1-4.
12. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
13. Arduni, A, et al. Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 1990;47(26):2395-2400.
14. Taglialatela, G, et al. Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol 1992;44(3):577-85.
15. Taglialatela, G, et al. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol 1994;29(1):55-56.
16. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
17. Forloni, G, Angeretti, N, Smiroldo, S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J Neurosci Res 1994;37(1):92-6.
18. Steffen, V, et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol 1995;14(11):865-71.
19. Fariello, RG, et al. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA. Life Sci 1988;43(3):289-92.
20. Calvani, M, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann Ny Acad Sci 1992;663:483-86.
21. Calvani, M, Carta, A. Clues to the mechanism of action of acetyl-L-carnitine in the central nervous system. Dementia 1991;2:1-6.
22. Zdanowicz, M. Acetyl-L-carnitine's healing potential. Continuing Education Module. New Hope Institute of Retailing. October, 2001.


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B Vitamins Avert Stroke, Coronary Disease, Death
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Date: January 25, 2006 04:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: B Vitamins Avert Stroke, Coronary Disease, Death

B Vitamins Avert Stroke, Coronary Disease, Death

London, Ontario--Taking B Vitamins may lower homocysteine levels, thereby reducing the risk of ischemic stroke, coronary disease and death, according to an efficacy analysis of the Vitamin Intervention for Stroke Prevention trial (VISP).

Published in Stroke (36, 11:2404-09, 2005) (//stroke.ahajournals.org), the analysis outlined researchers’ criticisms of VISP: Participants in VISP may have been administered folate-fortified grain products, the low-dose arm of the study may have been given the recommended daily intake for b12, low-b12 patients in both study arms may have been treated with parenteral b12, test subjects with malabsorption may have been administered an excessively low dose of b12, study participants may have been taking vitamins outside of the study, and patients with significant renal impairment may have failed to response to vitamin therapy.

In the efficacy analysis of VISP, researchers excluded patients with very low and very high b12 levels at baseline (less than 250 pmol/L and greater than 637 pmol/L, respectively, representing the 25th and 95th percentiles), in order to eliminate test subjects with b12 malabsorption, ongoing b12 supplementation outside the study and significant renal impairment. The resulting subgroup was comprised of 2,155 patients, 37 percent female, with a mean age of 66 plus or minus 10.7 years. There was a 21 percent reduction in ischemic stroke, coronary disease and death in the high-b12 dose group compared with the low-b12 does group. Kaplan-Meier survival analysis of the four groups indicated patients with b12 levels at the median or higher at baseline who were randomized to the high-b12 dose showed the best overall outcome, whereas those with baseline b12 levels lower than the median who were assigned the low-b12 dose had the worst general outcome.

In the era of folate fortification, b12 plays a key role in vitamin therapy for total homocysteine may be needed for some patients.



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Astragalus Fact Sheet
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Date: December 07, 2005 01:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Astragalus Fact Sheet

Astragalus Fact Sheet

Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg)

MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides.

ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!).

SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants.

CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
2. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
3. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
4. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
5. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
6. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
7. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
8. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
9. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.
10. Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1103-11. PMID: 15249203
11. Zhang BQ, Hu SJ, Shan QX, Sun J, Xia Q. [Relaxant effect of Astragalus membranaceus on smooth muscle cells of rat thoracic aorta.] Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Jan;34(1):65-8. Chinese. PMID: 15693127
12. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD, Chen J. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett. 2004 Jun 17;363(3):218-23. PMID: 15182947
13. Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem. 2004 Jun;11(11):1423-30.
14. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 521–3. 15. Klepser T, Nisly N. Astragalus as an adjunctive therapy in immunocompromised patients. Alt Med Alert 1999;Nov:125–8 [review].
16. Qun L, Luo Q, Zhang ZY, et al. Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Clin Nephrol 1999;52:333–4 [letter].
17. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: Springer Verlag, 1992, 1056.
18. Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus. Chung Kuo Chung His I Chieh Ho Tsa Chih 1995;15:77–80 [in Chinese].
19. Chen LX, Liao JX, Guo WQ. Effects of Astragalus membranaceus on Left Ventricular Function and Oxygen Free Radical in Acute Myocardial Infarction Patients and Mechanism of Its Cardiotonic Action. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Mar1995;15(3):141-3.
20. Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on Left Ventricular Function of Angina Pectoris. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1994;14(4):199-202,195.
21. Geng CS, et al. Advances in Immuno-pharmacological Studies on Astragalus membranaceus. Chin J Integ Trad West Med. 1986;6:62.
22. Shi HM, et al. Intervention of Lidocaine and Astragalus membranaceus on Ventricular Late Potentials. Zhongguo Zhong Xi Yi Jie He Za Zhi. Oct1994;14(10):598-600.
23. Griga IV. Effect of a Summary Preparation of Astragalus cicer on the Blood Pressure of Rats with Renal Hypertension and on the Oxygen Consumption by the Tissues. Farm Zh. 1977;6:64-66.
24. Kurashige S, Akuzawa Y, Endo F. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine. Cancer Invest. 1999;17(1):30-5.
25. Wei H, Sun R, Xiao W, et al. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep. Sep2003;10(5):1507-12.
26. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:56. American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.



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All SAM-e supplements are not created equal
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Date: October 26, 2005 12:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: All SAM-e supplements are not created equal

All SAM-e supplements are not created equal

During the manufacture of SAM-e, two forms are produced known as the S,S and the R,S isomers. The S,S isomer is the biologically active form in the human body, whereas the R,S form is considered to be inactive. Double Strength SAMe 400 utilizes Italian SAM-e to yield the highest available percentage of the active pure S,S form on the market. Double Strength SAMe 400 contains an average of nearly 80% of the active S,S form. Other SAM-e products contain as little as only 50% of the active form. A higher content of the active form yields a more potent product.

The molecule SAM-e itself is highly unstable. It will degrade quickly in conditions of heat, light and moisture. To increase its stability, it must be formed into a salt. It is important to note that SAM-e used for dietary supplements exists in a number of salt forms. Double Strength SAMe 400 utilizes the SAM-e tosylate disulfate salt form. This salt has been the most extensively utilized form in clinical trials of SAM-e.

Because of the unstable nature of pure SAM-e it is also highly susceptible to degradation in an acidic environment like the stomach. To be utilized effectively, it must pass through the stomach for absorption in the small intestine. For this reason, only enteric-coated formulas should be used. Double Strength SAMe 400 tablets are enteric-coated to maximize the utilization and benefit of the SAM-e by the body.

Benefits

Enhances Mood and Neural Function*

SAM-e has been studied for decades now for its potential role in enhancing mood and supporting healthy neural metabolism. In a double-blind placebo trial published in 1976, 30 individuals were given either SAM-e intramuscular injections (15 mg three times daily) or placebo. Individuals were assessed for improved mood and affect. It was found that 100% of patients in the SAMe group showed significant improvements in mood, while only 30% of the placebo group showed any improvement.1 The improvement seen with SAM-e in this trial was rapid, with a response time of between 4 and 7 days.

A second Italian double-blind placebo controlled study was published in 1987. Again, individuals showing signs of decreased affect and mood were administered 200 mg SAM-e as daily intramuscular injections, or a placebo, for four weeks. Each group consisted of 20 patients, with all medial and laboratory results being normal. Rating scales were used to monitor changes and the authors found that the treatment with SAM-e was significantly superior to placebo and was very well tolerated.2

Researchers had known that SAM-e injections showed benefit in mood enhancement based on the results of multiple clinical trials. However, with injections, chronic administration is always challenging. For this reason, oral doses are superior in terms of ease of administration. Studies were conducted to assess the efficacy of oral SAM-e preparations. One such study was published in 1990.

In this double-blind placebo-controlled trial, individuals were given increasing doses of SAM-e from 200 mg to 800 mg twice daily, or placebo, over the 21 day period of the trial. In the placebo group, one of the six individuals showed an enhancement of mood of 50% according to the rating scales, whereas 6 of the 9 individuals given the oral SAM-e showed a 50% or greater improvement in mood and affect.3 It was concluded that oral SAM-e, like SAM-e injections, can significantly enhance mood without significant side effects.

Another double-blind placebo controlled trial looked at the effects of administering 1600 mg of SAM-e, or placebo, daily to 80 women aged between 45 and 59. The administration took place for 30 days, after which the women were assessed for improvements. Rating scales were administered at 10 and 30 days. SAM-e supplementation significantly enhanced mood and affect in the women compared to placebo administration.4 SAM-e was also seen to be well tolerated, as three women in the placebo group and two women in the SAM-e group complained of minor side effects which did not interfere with continuation of treatment.



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8 Steps for Relieving Back Pain
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Date: August 02, 2005 02:02 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 8 Steps for Relieving Back Pain

1. POSTURE. Don’t sit in the same position too long. Distribute your weight between your feet when standing. Always align your shoulders and head with your torso. Carry weight mostly with your legs and keep any held objects close to the body.

2. HERBAL RUBS. For muscle spasms, rub a mix of lobelia, myrrh and cramp bark extracts with a touch of cayenne into your back. They will act as muscle relaxants and pain relievers. Rub into aching area as needed. This mixture stores for approximately two years.

3. DEEP BREATHING. When you experience pain, your breathing becomes shorter and your muscles are more tense. Breathing deeply allows more oxygen to arrive to the affected area, helping it heal more quickly. Lie on your back, close your eyes and slowly breathe in and out as deeply as you can. Visualize your body expanding and closing and the oxygen moving through your body to the muscles in pain. Continue this for 20–30 minutes.

4. MSM. MSM is a sulphur compound that can relieve pain associated with muscle cramps. It works by interrupting pain impulses heading to the brain. By taking 1,000 mg three times a day for one to six weeks, you should see marked improvement.

5. HEALTHY DIET. The food you eat affects every tissue cell in your body. Eat more fiber and drink more water. Limit your consumption of coffee, soda and other stimulants (they have an unnatural effect on the nervous system, which can lead to muscle disfunction). If you are overweight, you are adding extra strain on your back—a diet would be beneficial.

6. YOGA. Yoga is an excellent way to relieve muscle tension and promote strength and relaxation. Even trying two yoga poses daily should alleviate some back pain.

7. MAGNETS. A growing number of health professionals believe that magnets can help relieve back pain. Magnets reportedly encourage blood flow and reduce inflammation. In a recent study on the benefits of magnets on post-polio patients, magnets were found to reduce back pain by up to 75 percent.

8. MENTAL REFOCUSING. Often physical pain associated with the back is only part of the problem. Repressed emotions and stress, say some researchers, can trigger physical responses in the body. By focusing on the cause of your pain (i.e., daily stresses and problems, rather than the pain itself ), you can alleviate some of its symptoms.



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ARTIFICIAL SWEETENERS: CAUSE FOR WORRY
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Date: July 15, 2005 12:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ARTIFICIAL SWEETENERS: CAUSE FOR WORRY

ARTIFICIAL SWEETENERS: CAUSE FOR WORRY

Among some of the most troubling food additives that we routinely ingest are artificial sweeteners, also referred to as non-nutritive sweeteners. Having received the FDA stamp of approval, they are liberally ingested with little thought to what their actual health risks may be. Andrew Weil, M.D., in his book Natural Health Natural Medicine, writes: More worrisome than preservatives are artificial sweeteners. Saccharin, a known carcinogen, should be avoided. Cyclamates, banned some years ago for suspected carcinogenicity, are not being reconsidered for use in food. They taste better than saccharin but cause diarrhea in some people. Avoid them too. Recently, aspartame (NutraSweet) has become enormously popular. The manufacturer portrays it as a gift from nature, but, although the two component amino acids occur in nature, aspartame itself does not. Like all artificial sweeteners, aspartame has a peculiar taste. Because I have seen a number of patients, mostly women, who report headaches from this substance, I don’t regard it as free from toxicity. Women also find that aspartame aggravates PMS (premenstrual syndrome). I think you are better off using moderate amounts of sugar than consuming any artificial sweeteners on a regular basis. A natural sweetener that may cause some people problems is sorbitol, originally derived from the berries of the mountain ash tree. Sorbitol tastes sweet but is not easily absorbed form the gastrointestinal tract and is not easily metabolized. It is a common ingredient of sugarless chewing gums and candies. If you eat a lot of it, you will probably get diarrhea. People with irritable bowel syndrome or ulcerative colitis should avoid sorbitol.

Ann Louise Gittleman, in her book, Super Nutrition for Women, writes: In 1977, a Canadian study indicated that when pregnant rats were fed large doses of saccharin, their male offspring developed bladder cancer. As a result, the Canadians banned saccharin and the U.S. Congress ordered warning labels on all saccharin products like Sweet ‘N Low. The national Academy of Sciences in 1978 evaluated the evidence and concluded that saccharin was primarily a promoter of other cancer-causing agents, a cocarcinogen. In the meantime, G.D. Searle developed aspartame, a combination of two amino acids and methanol (wood alcohol) . . . Few long-term studies of the effects of aspartame have been done. However, reports to the Food and Drug Administration and the Centers for Disease Control indicate that, as more people consume the substitute in large quantities, health may be affected. In some circumstances, individuals may be getting high levels of methanol; for example, it is estimated that on a hot day after exercise, an individual drinking three 12-ounce cans of diet cola could easily consume as much as eight times the Environmental Protection Agency’s recommended limit for methanol consumption. The most common complaints are dizziness, disorientation, tunnel vision, ear buzzing, loss of equilibrium, numbing of hands and feet, inflammation of the pancreas, high blood pressure, eye hemorrhages and seizures. Artificial sweeteners can stimulate hunger or cause additive allergies, just as sugar does. In other words, we get the disadvantages of sugar, along with the proven or suspected disadvantages of artificial sweeteners. While thousands of Americans continue to consume aspartame in unprecedented amounts, controversy surrounding its safety lingers. Dr. Richard Wurtman of the Massachusetts Institute of Technology (MIT) has reported that abnormal concentrations of neurotransmitters developed when he fed laboratory animals large doses of aspartame. He believes that the phenylalanine content of the sweetener actually manipulates and alters certain brain chemicals which could initiate behavioral changes and even seizures. He also purports that while small quantities of aspartame may be safe, the cumulative effects of the compound—particularly if consumed with high carbohydrate, low protein snacks—could be serious (Wurtman I, 799-801, Wurtman II, 429-430, Wurtman III, 1060).

In spite of serious concerns, saccharine and aspartame packets sit in restaurant sugar bowls all over our country, while in Japan, natural stevia powder enjoys popularity as one of the best and safest non-caloric sweeteners available.

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Pain - Post Op and Relaxation
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Date: July 13, 2005 09:24 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pain - Post Op and Relaxation

Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR.

"Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music.

Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good.

"These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization.

Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz.

On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed.

Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery."

Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill.

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Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association.

The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998.

A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study.

There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity.

Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density.

The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group.

These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70.

"We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research.

"Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus.

As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D.

Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine.

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Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds.

"The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander.

"When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt."

Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain.

These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood.

"This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added.

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Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher.

Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal models, natural killer cell activity was suppressed by physical stress or surgery, resulting in a significant increase in tumor development.

These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study.

"We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University.

Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery.

The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page.

"Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk."

The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.

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ALPHA GPC - Improves Mental Performance
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Date: June 28, 2005 06:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ALPHA GPC - Improves Mental Performance

The quality of our life experience—and our ability to live life to the fullest—is a direct result of optimal brain function. Only a few years ago, nothing could be done to stem the tide of poor circulation, forgetfulness and “mental fog.” But neurological science exploration has identified a fundamental brain compound critical to attention, learning, memory, and even the higher cognitive functions of reasoning and intuition. Research confirms that L-alpha-glycerylphosphorylcholine (called Alpha-GPC for convenience) is crucial to neuronal function and structure. Derived from purified soy lecithin, Source Naturals ALPHA-GPC readily converts to acetylcholine in the brain, helping to maintain neuronal structure integrity. Source Naturals provides an easy and convenient means to profoundly impact the very nexus of our body and mind.

GPC Is Unique

No other nutritional compound comes close to GPC in its ability to boost critically important acetylcholine levels. Found in both the brain and the peripheral nervous system (including the nerve-muscle junctions), acetylcholine is a key nerve messenger molecule, or neurotransmitter. Aging brains are characterized by functional deficiencies in both acetylcholine and its cholinergic receptors. GPC is a highly bioavailable supplement that boosts acetylcholine levels to improve cognitive function. It is also a major choline reservoir, helping to protect the brain against damage from poor circulation and potentially toxic metabolites.

Deficiencies in acetylcholine can cause the body to break down phosphatidylcholine for its choline content, leading to the death of brain cells. Yet in controlled clinical trials of middle-aged subjects taking GPC, reaction time was enhanced and there was improved energy generation and electrical coordination in the brain. For older subjects, double-blind trials demonstrated that GPC had superior benefits over certain other brain nutrients for mental focus, recall, verbal fluency—a unique, marked overall enhancement of mental performance. GPC is an example of what the great Linus Pauling referred to as “orthomolecules,” that is, molecules that are “orthodox” or “correct” for the body. GPC excels as a protective nutraceutical for memory loss and mood enhancement. It protects cells of the brain (and other organs) from damage, shielding a range of important biomolecules against toxin build-up.

Extensive Clinical Testing

In clinical trials that involved more than 5,000 patients, GPC showed marked improvement in overall brain performance. Depending on the particular trial, 50-70 percent of the patients who received GPC had their mental functions improved to a degree “meaningful to life quality.” GPC has shown revitalizing effects on the declining brain, and preliminary evidence suggests GPC may act on the pituitary gland to partially restore its capacity to make vital for cell maintenance and longevity. Other unique brain features of GPC are its benefits for attention and recall in young healthy adults, and its superior bioavailability. GPC readily crosses the bloodbrain barrier to raise brain choline levels within a few hours following oral intake. GPC helps with body-mind integration by being a ready reservoir for acetylcholine. This neurotransmitter is ubiquitous in brain circuit maturation, expansion, renewal and repair, as well as in the “agility” or adjustments of the circuitry that occur during adult life. In addition, an animal study has shown that GPC increases the release of GABA (gamma-aminobutyric acid), the most important and abundant inhibitory neurotransmitter in the brain. It acts as a “balancer” for the brain and helps induce relaxation and sleep. Without sufficient GABA, neurons fire at random, unable to make sense of incoming signals. GABA helps minimize “neural noise,” making it easier to focus and concentrate.

Why you should take GPC:

  • • Mental performance is improved at all ages (including attention, concentration and recall).
  • • GPC supports mind-body “focus,” including reflexes, response time, and endurance.
  • • GPC has benefits for healthy aging.
  • • GPC protects all the body’s cells through its unique osmolyte capacities.
  • • GPC is naturally present in very high concentrations in healthy cells, and also in mother’s milk, where it is the major source of choline for the developing brain. While it may be the single best nutrient for the brain, GPC is also a broader supplement for active living and healthy aging because it supports optimal metabolic function in all the organs. GPC has a metabolically privileged relationship with DHA (docosahexaenoic acid, omega-3). These are combined to make cell membrane phospholipids essential to metabolic efficiency in kidney, liver, and muscle function, and for sperm maturation. These body-wide functions, combined with its known brain benefits, allow GPC to support the functional integration of the brain with the other organs. Don’t pass up this newly discovered option to enhance the quality of your life, health and higher mental functions. Explore your nearby natural food outlet and utilize discoveries such as GPC, which has already improved the health and chances of longevity for the millions who have been wise enough to join the Wellness Revolution.

    References:
    Parnetti L, Amenta F, Gallai V. 2001. Choline alfoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mechs Aging Dev. 22: 2041. Canal N, et al. 1993. Comparison of the effects of pretreatment with choline alfoscerate, idebenone, aniracetam and placebo on scopolamine-induced amnesia. Le Basi Raz Ter. 23: 102. De Jesus Moreno Moreno M. 2002. Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, doubleblind, randomized, placebo-controlled trial. Clin Ther. 25: 178.



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    CLINICAL APPLICATIONS OF CAPSICUM
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    Date: June 23, 2005 11:20 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CLINICAL APPLICATIONS OF CAPSICUM

    CLINICAL APPLICATIONS OF CAPSICUM

    Capsicum is a remarkable whole body stimulant that can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain and fight off infection. One very authoritative work on African plants suggests that Capsicum’s “regular ingestion is highly beneficial in hemorrhoids, varicose veins, anorexia, liver congestion and vascular conditions . . .the indigenous inhabitants of Africa and of the Antilles are remarkably free form all of these conditions as they use Capsicum fruit in their diet.”10 Most of the therapeutic actions of Capsicum are attributed to the alkaloid or glucoside content of the herb.11 The latest scientific studies conducted with Capsicum will be discussed in subsequent sections.

    Herbal Catalyst

    Because Capsicum boosts peripheral circulation and stimulates organ secretion, it expedites the therapeutic delivery and action of other herbs. In other words, the medicinal benefits of these herbs reach infected or inflamed tissue more rapidly due to enhanced blood flow.12 Consider the following statement: “Cayenne will insure the rapid and even distribution of the active principles of the rest of the herbs to critical function - al centers of the body, including those involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation. Cayenne is included in several other blends for this reason. In extremely small quantities it can dramatically increase the efficiency of most other herbs.”13 Many health practitioners believe that the key to healing is CAPSICUM stimulation. Capsicum stimulates eve rything from blood flow to peristaltic action in the stomach, to intestinal transit time. The re m a rkable ability of Capsicum to stimulate organ secretion and even heart action makes it one of the strongest natural stimulants known. Se veral different kinds of herbal blends targeting various body systems will utilize Capsicum to boost the formula’s efficacy.

    Cardiovascular Tonic

    Capsicum is said to be unequaled for its ability to boost circulation and increase heart action. Interestingly, cultures who consume significant amounts of cayenne pepper in their diet have much lower rates of cardiovascular disease.14 Capsicum exerts a variety of desirable actions on the entire card i ovascular system. It has the extraordinary ability to enhance cardiovascular performance while actually lowering blood pressure.15 A quote taken from a card i ovascular publication re a d s , “Capsaicin has also been shown to prolong cardiac action potential in atrial muscle . . .”16 Michael T. Murray, N.D., has stated, “ Cayenne pepper [Capsicum] should be recommended as a food for its beneficial antioxidant and cardiovascular effects.”17 Herbalists have considered Capsicum as a superior “f o o d” for the heart. In fact, in cases where a heart attack is suspected administering capsicum in hot water has been thought to help lessen the severity of the attack. Capsicum can also be placed on or under the tongue in emergencies involving heart attack, stroke or hemorrhaging. 18 Note: Using Capsicum for any heart-related problem, especially a suspected heart attack should never take the place of medical attention or a physician’s care.

    CAPSICUM Blood Cholesterol Reducer

    Various studies have conclusively demonstrated that Capsicum reduces the risk of developing atherosclerosis (hardening of the a rteries) by reducing blood cholesterol and triglyceride levels .19 Additional clinical studies conducted in India found that when cayenne was ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels was significantly inhibited. In addition, bile acids and free cholesterol were subsequently eliminated from the body through the stool.20 Interestingly, these tests revealed that using Capsicum was actually more effective in reducing cholesterol that capsaicin alone.2 1 Daniel Mowrey, Ph.D., emphatically points out that this is just one of many examples of the superiority of whole botanicals as opposed to their isolated components.22 Note: Using Capsicum in combination with Hawthorn is a particularly good cardiovascular tonic.

    Blood Pressure Equalizer

    While an added bonus of Capsicum’s capability to lower blood serum cholesterol is a decrease in blood pressure, additional evidence strongly suggests that the herb initiates other mechanisms that fight hypertension .23 “Cayenne, according to another study, also reduces the blood pressure in an even more direct manner: a number of years ago, a team of researchers discove red that capsaicin acts in a reflexive manner to reduce systemic blood pressure, a kind of coronary chemoreflex.”24 Adding Garlic to Capsicum creates an even better therapeutic blend for treating hypertension.

    Blood Detoxification CAPSICUM

    “Cayenne is a kind of catalyst in the blood purification process . . . it acts as a diaphoretic, stimulating the excretion of wastes in the swe a t . ”25 Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it would only stand to reason that it would also facilitate the faster removal of toxins from the bloodstream and lymphatic system. You may have already noticed that Capsicum is frequently added to blood-purifying herbal combinations. Circulatory Booster Researchers have found that the simulating action of Capsicum on surface capillaries can help to pre vent cold hands and feet.2 6 For this reason, it may be helpful for Reynaud’s Syndrome. Old remedies using Capsicum have even recommended placing it in socks to warm the feet and to help prevent frostbite. An old folk cure for a chilled body was a steaming hot cup of Capsicum tea. Free Radical Scavenger The rich flavonoid content of Capsicum gives it significant antioxidant capabilities. A recent study conducted in 1995 showed that Capsicum has a higher ascorbic acid content than chiles from the jalapeno or serrano varieties .27 Vitamin C and bioflavonoids can scavenge for dangerous free radicals which cause tissue damage and can predispose organs to degenerative diseases. Free radicals are found everywhere and are created as by-products of metabolic p rocesses including the act of breathing itself. Pollutants can expose the body to free radicals. An interesting study done in Mexico City and published in 1993 found that Capsicum extract was able to modulate the mutagenic activity of urban air samples.28 In other words, these potentially dangerous nitro - a romatic compounds found in polluted air were kept from mutating by red chile extract.29 Chemical breakdowns of Capsicum have also found that CAPSICUM the pepper is high in Provitamin A, which significantly contributes to its healing ability and immune fortification.30 Anti-Carcinogenic Compound Anti-cancer research recently tested Capsicum on laboratory rats and found that it does indeed demonstrate anti-cancer properties by inhibiting certain enzymes which can initiate the mutation of cells.31 What this implies is that taking Capsicum can afford the body some protection against the cellular mutation which occurs in malignant growths. Capsicum actually inhibited the formation of dangerous metabolites under laboratory conditions where they should have normally been activa t e d .3 2 This study implies that Capsicum may have many more sophisticated bio-chemical actions than previously thought.

    An Impressive Pain Killer

    Capsaicin has recently emerged as a remarkably effective pain reliever and has become the subject of recent clinical research . Applying capsaicin in cream or ointment form to painful joints, scar tissue or other painful conditions involving peripheral nerves confuses pain transmitters. In other worlds, capsaicin temporarily disrupts sensory nerve cell biochemistry there by impeding the relay of pain sensations from the skin surface. It does this by inhibiting a neurotransmitter called substance P. This specific compound is thought to be the main mediator of pain impulses from peripheral nerve endings.33 Substance P has also demonstrated its ability to inhibit inflammatory pain generated in arthritic joints in much the same way.34 Today, several over-the-counter topical preparations utilize capsaicin for the pain of arthritic joints. The ability of Capsicum to control severe and unresponsive pain is significant, to say the least. Modern clinical utilization of topical capsaicin may offer signifi-cant relief for a number of painful conditions including: diabetic neuropathy, cluster headaches, post-amputation pain, post-mastectomy pain, shingles and painful scar tissue.35

    POST-SURGICAL PAIN

    In the early spring of 1996, prime time national news show s reported that scientists had found that individuals who had suffered from chronic pain in post-surgical scars (heart bypass, arterial grafts, etc.) were successfully treated with topical preparations containing capsaicin. While this may have been news to many of us, clinical studies had been already published for several years that capsaicin held profound value for various kinds of pain which did not respond to established medical treatments. Typically surgical scars and regions around them can produce persistent pain or can be very sensitive to the touch even when completely healed. This type of pain phenomenon seems to respond well to capsaicin ointments and creams.

    POST-MASTECTOMY PAIN

    When capsaicin preparations were applied following mastectomy or breast reconstruction, pain was significantly relieved. Se veral double blind studies found that using capsaicin creams four times daily for 4 to 6 weeks resulted in much less frequent occurrence of sharp, jabbing pain.3 6 All thirteen patients studied had a 50 percent or greater improve m e n t .3 7 Various unpleasant sensations other than pain also improved with topical applications of capsaicin creams.38

    MOUTH SORES FROM RADIATION OR CHEMOTHERAPY

    A fascinating study conducted at the Yale Pain Management Center discove red that capsaicin could ve ry significantly lessen pain caused by mouth sores which frequently develop after chemotherapy or radiation.39 Apparently delivering the capsaicin in the form of soft candy (taffy) enabled the substance to be retained in the mouth long enough to desensitize the nerve endings causing the pain. Each one of the eleven case studies re p o rted that their pain had decreased and in two patients, it stopped entirely.40

    DIABETIC NEUROPATHY

    Diabetic neuropathy is a painful nerve condition which can develop in cases of prolonged diabetes. Several double-blind studies have supported the considerable value of capsaicin creams for relieving the pain associated with this disorder.41 The results of a controlled study using Capsicum for seve re cases of diabetic neuropathy which did not respond to conventional therapy were published in 1992. A cream containing Capsicum was applied to painful areas four time a day and pain was carefully e valuated for 8 weeks at two-week intervals. The results we re impressive, to say the least. In the 22 patients who used the Capsicum the following results we re re c o rded: “Capsaicin tre a tment was more beneficial than vehicle treatment in the overall clinical improvement of pain status, as measured by physician’s global evaluation and by a categorical pain severity scale . . . In a follow-up study, approximately 50 percent of the subjects reported improved pain control or were cured . . .”42 No t e : While there was a burning sensation when the Capsicum c ream was first applied, some subjects found that its magnitude and duration lessened with continued application.43

    SHINGLES

    The FDA has approved capsaicin-based ointments for the treatment of pain that results from diseases like shingles. Again, numerous studies have documented the value of capsaicin for decreasing the miserable nerve-related pain associated with shingles. The general consensus derived from these tests were that approximately 50 p e rcent of people suffering from shingles responded well to capsaicin creams, some even after 10 to 12 months.44

    Note: If blisters accompany a shingles outbreak, it is better to wait until they have healed before using any capsaicin-based ointments or creams.

    RELIEF FOR BURNING FEET

    Frequently an uncomfortable “burning” sensation in the feet will occur in many people, particularly in diabetics. As ironic as it may seem, using capsaicin creams may actually alleviate this burning. “In various studies, diabetics who treated their burning feet with capsaicin got greater improvement and we re able to walk more easily than those not using the cream.”45 In addition, using topical applications of capsaicin as opposed to strong, oral drugs is much more preferable.

    ARTHRITIS PAIN

    Clinical tests have confirmed that topical capsaicin ointments substantially alleviate the miserable pain that characterizes osteoand rheumatoid arthritis.46 These studies revealed that using 0.075 capsaicin cream reduced tenderness and pain.47 Dr. Michael T. Murray writes: “ . . . seventy patients with osteoarthritis and thirty - one with rheumatoid arthritis received capsaicin or placebo for 4 weeks. The patients were instructed to apply 0.025 percent capsaicin cream or its placebo to painful knees four times daily. Significantly more relief of pain was reported by the capsaicin-treated patients than by the placebo patients throughout the study . . .”48 Anyone suffering from osteo or rheumatoid arthritis should evaluate the effectiveness of capsaicin ointments for joint pain. Ester Lipstein-Kresch, M.D., has studied the effectiveness of capsaicin creams for arthritis and has stated: “You need to apply it three or four times a day on the affected area for at least two weeks before you’ll see any improvement. An initial burning sensation at the site is not unusual for the first few days, but this goes away with continued application.”49 Note: Capsaicin is also useful for tennis elbow due to its ability to block the transmission of pain.

    MIGRAINE HEADACHES (CLUSTER TYPE)

    Topical applications of capsaicin ointments intranasally may also help to relieve the pain of a specific kind of migraine headache called cluster headaches. Cluster headaches are characterized by s e ve re pain which typically radiates around one eye. The term “cluster” refers to the fact that these headaches tend to occur in clusters of one to three per day and can recur at intervals. Headache pain and severity we re reducing in groups using intranasal capsaicin.5 0 This type of capsaicin treatment should be done under a physician’s care. There is some speculation that capsaicin may be more effective in pre venting migraines before they develop into a full blown attack.51

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    GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....
    TopPreviousNext

    Date: June 21, 2005 05:25 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....

    GPC (GlyceroPhosphoCholine): Versatile Life Support Nutrient

    Parris Kidd, Ph.D.

  • GPC - Marked Benefits to the Brain
  • GPC Supports Normal Brain Function
  • GPC Works Through Multiple Mechanisms
  • Dosing, Safety, Tolerability, Compatibility
  • GPC: Nutrient for All Ages
  • GPC or GlyceroPhosphoCholine (pronounced gli-sero-fos-fo-ko-lean) is a nutrient with many different roles in human health. It reaches extremely high concentrations within our cells, and its abundance in mother's milk suggests it is crucial to life processes. Clinically, GPC has been most intensively researched for its brain benefits. Biologically, it has great importance for the skeletal "voluntary" muscles, the autonomic nervous system, kidneys, liver, and reproductive organs. GPC goes beyond being a brain nutrient; it is a nutrient for vitality and long life.

    Marked Benefits to the Brain

    As a dietary supplement, GPC's brain benefits are unique. It boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. In the elderly, GPC improves mental performance and provides noticeable revitalisation. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals.

    GPC Supports Normal Brain Function

    Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve.

    GPC Works Through Multiple Mechanisms

    GPC supports human health through a variety of mechanisms:

    1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline. Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination.

    2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup.

    3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PC-DHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency. GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency.

    4. GPC contributes to both male and female in reproduction. As spermatozoa mature, GPC is used to make PC-DHA that makes their membranes fluid to enable motility. With men, the lower their semen GPC the greater the likelihood of poor sperm motility and with it, infertility. Once semen is inserted into the female, an enzyme in uterine secretions breaks down the semen's GPC into substances that energize the sperm to achieve fertilization.

    Dosing, Safety, Tolerability, Compatibility

    Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses (AM and PM) between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams. GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline.

    GPC: Nutrient for All Ages

    GPC is unmatched for its support of active living and healthy aging. In some 23 clinical trials GPC improved mental performance in all functional categories. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions. GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.

    Parris M. Kidd, PhD is a cell biologist trained at the University of California, Berkeley and San Francisco. Since entering the dietary supplement field in 1983, he has published many in-depth reviews of integrative medicine in the journal Alternative Medicine Reviews, and is science columnist for totalhealth magazine. Dr. Kidd is internationally recognized for his accomplishments in dietary supplement product development, documentation and quality control.

    Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.



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    Defeat Depression
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    Date: June 13, 2005 01:18 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Defeat Depression

    Defeat Depression

    by Cal Orey Energy Times, August 2, 1999

    Depression plagues the creative and the mundane. The disparate desperate driven to distress by depression include painters, poets, actors and musicians as well as truck drivers, clerks, electricians and physicists. The victim list encompasses Vincent van Gogh, Emily Dickinson, Audrey Hepburn, Virginia Woolf and Ludwig von Beethoven, as well as millions of other sharers of melancholy misery.

    More than 17 million American men and women experience depression in one form or another every year, according to the National Mental Health Association (NMHA) in Alexandria, Virginia. This includes the deeply destructive major, or clinical, depression, the wide mood swings of bipolar disorder (manic-depressive illness), and dysthymia, a milder, long-lasting form of emotional suffering.

    Twice as Many Women In the depression scenario, women suffer twice as much: Two times as many women as men endure clinical depression, reports the NMHA. The mood-deteriorating effects of the hormonal disruptions women are heir to may be partly to blame.

    According to the National Institute of Mental Health (NIMH), about one of 10 Americans wades through at least one depressive swamp sometime during his or her life.

    The good news: Research shows that diet and lifestyle can lower your risk of depression.

    Birth of the Blues

    Nowadays, mounting evidence suggests that depression may result more from physiological factors than psychological woes.

    Some of the hidden reasons why you may be depressed include: nutritional deficiencies, exacerbated by overdosing on too much caffeine, sugar, alcohol and high fat foods; allergies; anxiety and chronic stress; and a chemical imbalance in the brain's gray matter. According to the NMHA, people with depression often possess too little or too large a quantity of the neurotransmitters norepinephrine, serotonin and dopamine. Changes in levels of these brain chemicals may cause, or contribute to, clinical depression.

    The NMHA also reports that an imbalance of melatonin, a chemical made by the body's pineal gland (located at the base of the brain), contributes to a form of wintertime depression called seasonal affective disorder (SAD). This hormone is made at increased levels in the dark. Therefore, the body may oversupply this hormone during winter's shortened daylight hours.

    Plan B

    Since the B vitamins are often involved in the production of energy, and a large component of depression may encompass the inability to get out of bed and deal with the world, experts believe that at least some of the signs of depression are linked to B deficiencies. For instance, studies cited in the Encyclopedia of Natural Medicine (Prima) by Michael Murray, ND and Joseph Pizzorno, ND, demonstrate that folate deficiency and lack of vitamin B12 can compromise mental health (Drugs 45, 1993: 623-36; Lancet 336, 1990: 392-5).

    Inositol: This vitamin is also part of the B vitamin complex, and it, too, has shown its ability to lift spirits. Research work in Israel shows that daily inositol given to 28 depressed patients for four weeks produced an overall positive effect. (Eur Neuropsychopharmacol 7:2, May 1997: 147-55). Inositol is found in whole, unprocessed grains, citrus fruits (except lemons) and brewer's yeast.

    NADH: Allan Magaziner, DO, in his book The Idiot's Complete Guide To Living Longer & Healthier (Alpha), reports that brain energizing NADH, a metabolite of vitamin B3, enhances the production of the key neurotransmitters dopamine, noradrenaline and serotonin. "In a recent clinical trial," he claims, "nearly all patients given NADH for depression reported improvement in their symptoms and the absence of side effects or adverse reactions."

    Moody Spotlight

    Another substance winning the spotlight for its effect on mood is SAM-e: S-adenosylmethionine. In New York on February 24, a symposium coordinated by the American Health Foundation met to hear researchers present information from studies of SAM-e's ability to possibly ease depression.

    "SAM-e is a natural product. You and I have it but as people age it declines in production in the body. And that's why we believe supplementation in older people is a beneficial means of bringing that back up and helping people that have depression," said the lead symposium researcher, John H. Weisburger, PhD, MD, Director Emeritus, American Health Foundation in Valhalla, New York.

    Another researcher, Teodoro Bottiglieri, PhD, Associate Professor of Biomedical Studies and Neurology, Director of Neuropharmacology at Baylor University reported: "SAM-e has been shown to enhance brain dopamine and serotonin neurotransmitter metabolism and receptor function. It may also aid in the repair of myelin that surrounds nerve cells. These mechanisms are likely to be responsible for the antidepressant effect of SAM-e."

    (Bottiglieri is co-author with Richard Brown, MD, and Carol Colman of Stop Depression Now, a report on the powers of SAM-e just published by G.P. Putnam's Sons.)

    SAM-e was first touted as an antidepressant in Italy in 1973. It's been reported that nearly 40 clinical trials demonstrate its beneficial effects as a natural antidepressant.

    For instance, an analysis of more than 1000 people suffering depression showed that the effect of antidepressants in patients taking SAM-e was 17% to 38% better than dummy preparations. Conventional antidepressants show a 20% effectiveness rate (Bressa G. Acta Neurol Scand S154, 1994: 7-14).

    5-HTP: Another popular supplement to boost mood and relieve depression is hydroxytryptophan. "This medication is actually a brain chemical that is metabolized from tryptophan into serotonin," says Magaziner. And since low serotonin levels have been linked with depression, and certain prescribed medications may up serotonin levels, 5-HTP is in demand.

    "One of the more impressive studies supporting the efficacy of 5-HTP for depression evaluated 100 people who had previously found conventional antidepressant therapy to be inadequate. Forty-three of these folks reported a complete recovery, and eight showed significant improvement," reports Magaziner. Not only has 5-HTP been shown to work slightly better than drugs known as SSRIs (these include Prozac), he adds, it has fewer side effects than standard antidepressants, too. DHEA: Medical experts also believe that levels of the hormone DHEA (dehydroepiandrosterone) may influence mood. Ray Sahelian, MD, in his book All About DHEA (Avery) reports an interesting study conducted by Dr. Owen Wolkowitz of the Department of Psychiatry, University of California, San Francisco. A group of six depressed middle-aged and elderly individuals who took DHEA found that within a month they had better memory and mood. (Biological Psychiatry 41, 1997: 311-18.) "In addition," adds Sahelian, "other studies have also found that DHEA increases energy levels and a sense of well being." But follow package directions: Some people complain of greater irritability and overstimulation with DHEA, when they take large amounts.

    Herbal Relief

    St. John's wort: still the most touted natural therapy for defeating depression. In Europe, 23 clinical studies, reviewed in the August 3, 1996 British Medical Journal, found that this herb, also known as Hypericum perforatum, can be helpful in alleviating cases of mild to moderate depression. The work, which included 757 patients, has shown that hypericum produced fewer side effects than conventional anti-depressants.

    Although experts have never satisfactorily explained exactly how St. John's wort benefits the brain, some theorize that it boosts serotonin levels. And it can help SAD sufferers.

    "In a recent study of 20 people with SAD, four weeks' worth of St. John's wort significantly alleviated feelings of depression. Those people who added full-spectrum lights to the treatment program gained an even greater benefit," notes Dr. Magaziner.

    Valerian: Anxiety and stress, which can cause depression and insomnia, may be helped by this herb, says the prolific Dr. Sahelian in his book Kava: The Miracle Antianxiety Herb (St. Martin's). In 101 Medicinal Herbs (Interweave), Steven Foster reports that "Ten controlled clinical studies have been published on valerian...one of which suggests that valerian should be used for two to four weeks before daily mood and sleep patterns improve."

    Amino Acid Help

    Amino acids, the building blocks of protein, may also help improve mood. (For more on protein, see page 65.) These chemicals are used by the body to construct neurotransmitters, brain chemicals that facilitate mental activity.

    For instance, the amino acid L-tyrosine is necessary for the formation of transmitters adrenaline and dopamine. This substance, therefore, is given to alleviate depression and anxiety.

    The substance L-dopa which is given to victims of Parkinson's disease is concocted from tyrosine. And several antidepressants alleviate bad moods by boosting the interaction of brain chemicals related to tyrosine.

    In addition, since tyrosine is used to make adrenaline, this amino acid may be helpful for folks trying to cope with the mood problems related to stress.

    Another amino acid that experts believe useful for better moods, L-methionine, is used by the body to make choline, a crucial substance for brain function. (Choline goes into the formation of acetylcholine, a neurotransmitter.)

    Methionine has been given to people suffering from schizophrenia and depression as well as to those with Parkinson's. Methionine plays a number of crucial roles in the brain and body since it helps form other vital proteins.

    Depressive Smoking

    For those concerned about preserving a positive mood, researchers are positive that smoking worsens depression. A study at the Department of Behavioral Services at the Henry Ford Health System in Michigan found that daily smokers run twice the risk for major depression compared to those who only smoked occasionally.

    Unfortunately, the investigators found that not only did smoking seem to lead to depression, depression, in turn, led to more smoking (Archives of General Psychiatry, 2/99).

    "Smokers who have depression tend to see their smoking become a daily habit and it may be because they use nicotine to medicate their depressed mood," reported Naomi Breslau, PhD, who headed the research. Over a five year period, the researchers looked at about a thousand young people aged 21 to 30. They found that daily smokers generally start smoking in adolescence, and those who report early depression are three times as likely to eventually become daily smokers.

    If you're feeling down, don't give up hope. Although depression can prove to be a depressingly complicated malady, daily, healthy habits can offset its effects. Getting consistent exercise, dousing your cigarettes and turning to herbal and nutritional help to treat mild depression may defeat those blues.



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    The Flex Factor
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    Date: June 11, 2005 05:18 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The Flex Factor

    The Flex Factor by Thomas Dunville Energy Times, February 10, 2004

    Arthritis, according to recent research, presents its sufferers with a Catch-22: The nagging pain of this condition can send your spirits plummeting. But, then, the depression spurred by the disconsolate persistence of arthritic pain can make the condition worse.

    Part of the trick is not to give in. If you can keep a bright mood even as your joints start to ache, the pain may lessen.

    While nobody can offer a guaranteed, 100% effective cure for arthritis, you don't have to be a passive victim. Exercise, the proper nutrients and a positive, can-do attitude can ease arthritis pain so effectively that scientists have been able to measure the difference. While medical researchers recognize the existence of over 100 types of arthritis, most people with achy joints suffer from osteoarthritis, which is caused by everyday wear and is found in just about everyone over age 60. When this condition occurs, the body's cushioning, its cartilage, thins and the inner surfaces of joints grind together painfully.

    Although aging itself increases your chances of enduring achy joints, other factors can also put you in the way of osteoarthritis. If you carry too much weight, it can wear on your joints. In addition, suffering a joint injury when you're young can increase your risk of developing osteoarthritis as you age.

    In another prevalent form of joint pain, rheumatoid arthritis (RA), the body's immune system mistakenly attacks the membranes lining the joints, causing swelling and pain. About 2 million Americans suffer from RA, which affects women about twice as often as men.

    Exercise Away Arthritic Woes

    Weekend warriors, don't despair! Arthritis doesn't have to mean the end of your weekend athletic wars. Matter of fact, in many cases, experts now recommend exercise to reduce the effects of arthritis.

    While that might sound counterintuitive, a study out of the Netherlands shows that folks in the early stages of rheumatoid arthritis who work out twice a week for about an hour each session may enjoy better physical and mental health than couch potatoes who receive physical therapy.

    The Dutch study took 150 people, many of whom had just started to suffer from rheumatism, and enrolled them in RAPIT, an acronym for Rheumatoid Arthritis Patients in Training. Rather than letting these folks rest their inflamed joints, twice a week the research team took them to the gym where they did:

  • • Weight lifting: 20 minutes
  • • Stationary biking: 20 minutes
  • • Playing a strenuous sport like basketball or volleyball: 20 minutes
  • • Cooling down with stretches: 15 minutes

    When the researchers compared the physical changes in these arthritis sufferers with 150 others with similar arthritis complaints who underwent physical therapy without organized physical activity, they found that after two years the exercisers had benefited greatly. They were stronger and more aerobically fit, could perform everyday tasks more effectively and possessed a better, more optimistic mental attitude (Arthritis and Rheumatism 2003; 48(9):2415-24).

    However, the exercisers who were already suffering severe rheumatoid arthritis did experience some extra joint damage, so the researchers believe this kind of program is better for those in the early stages of the disease. " This study demonstrates that participation in long-term high-intensity exercise classes decreases the level of psychological distress in RA patients," says researcher Zuzana de Jong, MD, a professor at the Leiden University Medical Center in the Netherlands.

    Fish Oil Lowers Arthritis Risk

    Fish oil-in particular, cod liver oil-may be able to help ease osteoarthritis.

    In looking at the effects of fish oil, researchers at Cardiff, Wales, discovered indications that "...the omega-3 fatty acids in cod liver oil can reduce cartilage degradation and inflammation in arthritic disease," according to Bruce Caterson, PhD, one of the scientists involved.

    Dr. Caterson adds, "Our most recent work shows that by exposing human osteoarthritic cartilage to cod liver oil in the laboratory for just 24 hours we can turn off, or reverse, the action of the degradative enzymes and inflammatory factors affecting the tissue." John Harwood, PhD, another member of the Cardiff research team, adds, "This is where science and old wives' tales coincide. Our findings are consistent with advice that taking cod liver oil in early adulthood could prevent the onset of osteoarthritis and would reduce the harmful symptoms associated with the disease."

    Dr. Caterson further explains that the omega-3 fatty acids in cod liver oil inhibit enzymes that break down aggrecan and collagen, substances that cushion joints. Consequently, cartilage stays healthier, inflammation is lessened and arthritic pain decreases. The anti-inflammatory action of omega-3s in fighting rheumatoid arthritis is also supported by studies performed in the US (Am J Clin Nutr 2000; 71(1 Suppl):349S-51S).

    Other research shows that if you take natural vitamin E along with fish oil, you may improve even further your odds of relieving arthritis or lessening its effects (JACN 10/30/00).

    Glucosamine Repair

    Glucosamine, the stuff that cartilage is made from, has been shown to lower the risk of arthritis and possibly relieve its pain. This natural substance, made from a sugar and a molecule called an amine, is a building block of joint tissue. As a result, experts believe, when you take it in supplemental form, the body may use it to repair joints that have been damaged by arthritis. For instance, an investigation of osteoarthritis of the knee performed at the University of Liege in Belgium showed that taking glucosamine could stop joints from deteriorating.

    The study, which involved more than 200 people suffering from osteoarthritis, found that in three years of taking glucosamine supplements, many arthritis sufferers found that their condition actually improved (Lancet 2001 Jan 27; 357).

    Other Arthritis Fighters

    Chondroitin sulfate is another material that goes into the making of cartilage. Chondroitin helps cartilage stay hydrated and permits the flow of nutrients through the joint tissues. In addition, researchers believe that chondroitin helps fight inflammation, which can otherwise cause pain and stiffness as well as joint destruction.

    Taken together with glucosamine, chondroitin is believed to hasten the healing of bone and cartilage. Another substance that may help ease the ache of arthritis is methylsulfonylmethane (MSM), a naturally occurring sulfur-bearing compound. "MSM appears to have anti-inflammatory effects when administered orally, intravenously or topically," says MSM researcher Stanley Jacob, MD, FACS, of the Oregon Health & Science University. That means it has shown an ability to reduce the heat, pain and swelling associated with arthritic conditions. MSM may also be able to reduce muscle spasms around joints and reduce the formation of scar tissue.

    Herbal Aid

    Herbal medicine has long been used by folks with achy joints. The yellow spice turmeric (Curcuma longa), a staple of Indian cooking, is a traditional Indian remedy for arthritis because of its painkilling properties. Ginger (Zingiber officinale), another culinary favorite, restrains the production of inflammatory chemicals called cytokines. And willow bark (Salix sp), the source of aspirin, is longer-acting and doesn't irritate the stomach lining.

    Those who suffer arthritis know that its pain and discomfort are often no laughing matter. But if you don't take arthritis lying down and manage to keep a smile on your face-and avail yourself of nature's remedies-you can get the upper hand on this often debilitating condition.



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    Multidophilus 180ct ...
    TopPreviousNext

    Date: May 18, 2005 05:30 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Multidophilus 180ct ...

    There is no doubt that antibiotics have saved numerous lives since their development. But many health care providers in the past have seen them as a panacea for all ailments including viral infections that are not affected by antibiotic therapy. They have been overused and with disastrous results. Antibiotics are used to help the body in fighting infection, but unfortunately, they also may encourage recurrent infections caused by a destruction of the good as well as the bad bacteria lowering the immune function and leading to a dependence on antibiotics. Because of an overuse and misuse of antibiotics, some forms of bacteria are now resistant to them. Diseases which were aided with antibiotic therapy are now resistant to the treatment. Antibiotics are sometimes prescribed by physicians even when they are not appropriate.4

    Medical professionals almost felt guilty a few years ago when not prescribing some form of antibiotic when patients visited the office. After all, what good is a doctor if the patient does not leave with a cure. Fortunately, most doctors now know the detrimental affects that can follow excessive and inappropriate use of antibiotics. Most doctors now will be honest and up front with their patients when there is not a cure-all answer to their problem. An investigative reporter a few years ago visited a number of physicians around the country asking for antibiotics. It was interesting to note

    that almost all of the physicians agreed to prescribing antibiotics upon the patients request even when it wasn’t warranted. In being confronted after, most replied that they had to do what the patient asked in order to keep their practice flourishing. No wonder antibiotic overuse has resulted in drug-resistant strains of bacteria. The negative affects of antibiotics are well known. Antibiotics interfere with the growth of bacteria, both good and bad. But they are crafty creatures and have the ability of changing their chemistry and genes to avoid destruction by antibiotics. They want to survive and thrive. They grow at a very rapid rate allowing for a whole generation of drug resistant strains to develop in just a relatively short period of time. Alexander Fleming, who discovered penicillin, warned of the problem that could occur with resistant strains if antibiotics were overused.5 The weaker bacteria may be killed while the stronger endure. This causes the strong, resistant bacteria to invade and take hold in the body. Mitchell L. Cohen, a researcher with the National Center for Infectious Diseases at the Centers for Disease Control, issued this warning about antibiotics in 1992: “Unless currently effective antimicro b i a l agents can be successfully preserved and the transmission of drug-resistant organisms curtailed, the postantimicrobial era may be rapidly approaching in which infectious disease ward housing untreatable conditions will again be seen.” Patients, doctors, scientists and Acidophilus

    public health officials must all play their part in finding ways to reduce reliance upon antibiotics.6 Lactobacillus acidophilus is one of the most essential bacteria found in the intestinal tract. It helps to keep the disease causing organisms under contro l . Antibiotics can reduce the quantities of good and bad bacteria often allowing negative organisms to flourish. Broad spectrum antibiotics are the worst offenders often making way for an overgrowth of yeast which can affect the entire body. The broad spectrum antibiotics work just as they are called, broadly throughout the body, to kill just about all the bacteria around. If an antibiotic is warranted, the most specific type for the condition should be tried first in order to protect as much of the normal intestinal flora as possible. When taking antibiotics, Lactobacillus acidophilus can be taken by mouth to help restore normal intestinal flora. Acidophilus will not interfere with the effectiveness of the antibiotics but protect and aid in the healing process. Antibiotic use should be minimized; used only when essential to health and survival. The beneficial bacteria are the first to be destroyed from the antibiotic therapy. Lactobacillus acidophilus can also help to fight the bad bacteria and organisms that invade the body.

  • Natures AntiBiotic - Multidophilus 12 Probiotic Supplement 100ct

  • Natures AntiBiotic - Multidophilus 12 Probiotic Supplement 50ct

  • Probiotic Multidophilus 180ct



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    Bee Propolis may limit production of DHT...
    TopPreviousNext

    Date: May 17, 2005 05:00 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Bee Propolis may limit production of DHT...

    Chrysin controls aromatase activity, and thus the production of estradiol and estrone, and provides an alternative embodiment of this invention. This embodiment may further comprise a substance that controls 5-alpha-reductase and its production of DHT.

    Other aromatase inhibitors include substituted androstenediones. There is also evidence that aromatase is involved in the production of DHT, which is well known for its negative effects on the prostate and male pattern baldness. An in vitro rat testis cell suspension model was used to investigate the metabolism of tritiated testosterone, dihydrotestosterone, and androstenedione. In the presence of aromatase inhibitors and androstenedione, the metabolism was shifted towards 17-keto forms. This suggests that androstenedione and the derived aromatase inhibitors activate the 17 .beta.-hydroxysteroid-dehydrogenase in a product-activating manner. Thus, aromatase inhibitors may regulate the intratissular levels, not only of estrogens, but also of other hormonally active steroids like DHT and 5-androstenedione. Schroder et al., 31(4B) J. STEROID BIOCHEM. 685-90 (1988).

    Because of the usefulness of inhibiting aromatase in breast cancer patients, several synthetic aromatase inhibitors have been developed. See, e.g., U.S. Pat. No. 4,954,446. There are natural substances, however, such as chrysin, that have similar activity. Chrysin is a bioflavonoid found in propolis (bee pollen) and honey that has been demonstrated to be as potent and effective in inhibiting aromatase as the popular pharmaceutical, aminoglutethimide (AG). In aromatase enzyme assays, chrysin, 7,8 benzo-flavone (ANG), AG, flavone and genistein 4'-methyl ether (5,7-dihydroxy-4'-methoxyisoflavone, Biochanin A) were shown to inhibit aromatase. Chrysin and AG inhibited the enzyme by 50% at a concentration of 4.6 .mu.M and 7.4 .mu.M, respectfully, and only ANG had a high I.sub.50 of 0.5 .mu.M. Both Flavone and Biochanin A inhibited aromatase, but to a lesser degree. Campbell et al., 46(3) J. STEROID BIOCHEM. MOL. BIO. 381-88 (1993). In screening for potential chemopreventives against cancer, chrysin was one of the three of flavonoids with the greatest aromatase-inhibiting activity, with an inhibitory concentration (IC) of 1.1 .mu.g/mL. Jeong et al., 22(3) ARCHIVES PHARMA. RES. 309-12 (1999).



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