Genus Rubiaceae

Common Names

Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.

Parts Used

The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.

Physical Description

Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.

Chemical Constituents

Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.

FLOWER

FRUIT

discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.

ROOT AND ROOT BARK

Pharmacology

Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.

Body Systems Targeted

The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.

Satety

Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.

Suggested Uses

Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .

NONI: ITS USE AND HISTORY

Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .

Wonder Herb of Island Folk Healers

Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.

Noni’s Medical Reputation

Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.

A Timely Reemer gence

Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.

TRADITIONAL USES OF NONI

Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15

decoctions to stimulate delayed menst ruation.

XERONINE: THE SECRET OF NONI?

One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .

Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18

NONI PROCESSING

How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.

MODERN APPLICATIONS OF NONI

Overview

Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.

Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.

xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.

Cancer

A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21

In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.

Arthritis

with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.

Immune System

The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.

The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.

Antioxidant

The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.

Diabetes

While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.

Pain Killer

A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29

Skin Healing Agent

One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.

burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30

Drug Addiction

The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.

Complementary Agents of Noni

PrimaryApplications of Noni

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Date: July 07, 2005 05:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Heart Disease - Pollution Connection

Heart disease isn't the illness we usually associate with the health hazard known as pollution, but perhaps it should be. While pollution is strongly (and rightly) linked to cancer in the public mind, officials now realize that airborne junk can gum up the circulatory system. They've even coined a term for it: environmental cardiology.

The main villain is fine particulate matter, present in factory and vehicle emissions. These particals are so small they sift right through the lungs and into the bloodstream. There, fine particulate ignites inflammation, accelerates arterial narrowing, thickens blood and disrupts the heart's pacemaking mechanism. Other airborne pollutants hazardous to the heart include carbon monoxide and sulfur dioxide.

As young as it is, environmental cardiology has already taken some interesting turns. At least 17 of 87 government-monitored water contaminants have been linked to cardiovascular disease. Even more intriguing is the theory that pollution may wreak heart disease during adulthood.

After years on the research fringe, environmental cardiology moved to center stage with the publication of its own American Heart Association Scientific Statement, which concluded the air pollution poses as "Serious public health problem" in terms of heart disease. A pronouncement from such a mainline health group has translated into big bucks for studies. The biggest so far: a $30 Million, 10-year effort, led by the University of Washington, that will evaluate roughly 8700 people for signs of pollution sparked cardiovascular illness.

No one is discounting such traditional heart risk factors as poor diet and insufficient exercise. But the air we breathe is making many of our hearts sick and it's about time big medicine started sitting up and taking notice. --Lisa James....

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Vitanet ®

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Date: June 29, 2005 01:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness

CHOLESTEROL RESCUE

You live in a fat-drenched, fast food world, propped up by diets loaded with processed foods that stimulate your body to create excess bad cholesterol – or low-density lipoproteins (LDL). Your busy life is full of stress, and devoid of time for proper exercise. There are three ways to deal with cholesterol in the body, but a seemingly infinite number of lifestyle and hereditary elements that affect LDL levels. Is it any wonder you find yourself in danger of developing unwanted cholesterol levels? Source Naturals is devoted to helping you. So we developed CHOLESTEROL RESCUE as a comprehensive solution to help you keep cholesterol levels in the normal range. CHOLESTEROL RESCUE uses only natural ingredients, clinically researched to effectively maintain healthy cholesterol levels. It is scientifically formulated with the triple action of three ingredients that target the ways you can deal with your cholesterol concerns; combining the naturally occurring polymethoxylated flavone (PMF) and tocotrienol action of Sytrinol™ with the action of plant sterols. Research suggests that daily consumption of 800 mg of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease. Source Naturals offers CHOLESTEROL RESCUE as part of our ongoing commitment to providing you with high quality natural supplements to support your healthy lifestyle.

Cholesterol & Your Body

On average, humans ingest approximately 300mg of cholesterol per day. Though an important part of a healthy body, a high level of cholesterol in the blood might be out of the normal range. Cholesterol is transported in your system by lipoproteins. There are two kinds of lipoproteins in your body, but the low-density lipoproteins, or LDL, are the major factors in developing unwanted cholesterol levels. If there are high levels of LDL circulating in your bloodstream, it can undergo oxidation by free radicals in the artery walls, which can then become trapped as imbalanced deposits. These deposits can build up, reducing critical blood-flow. CHOLESTEROL RESCUE has been specially developed to reduce LDL levels using two different methods: inhibiting the synthesis of cholesterol in the liver, and reducing the absorption of dietary cholesterol.

The Plant Sterol Effect

Sterols are an essential component of the cell membrane, and are produced by both plants and humans. While the most common sterol produced in humans is cholesterol, plants produce phytosterols, or plant sterols. Using a complex compound of plant sterols similar to cholesterol with only slight molecular differences, CHOLESTEROL RESCUE has been formulated to balance the amount of dietary cholesterol your body absorbs.

Plant sterols have long been known to inhibit the uptake of both dietary and bile-produced cholesterol in the intestines. The most plausible theory behind this is that, because of the similarity between plant sterols and cholesterol, the body cannot properly distinguish between the two during the absorption process, thereby displacing the uptake of cholesterol into your system. Research suggests that daily consumption of 800mg of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease.

Sytrinol™ For Heart Health

CHOLESTEROL RESCUE also contains SYTRINOL™, a proven natural alternative for maintaining cholesterol wellness. The patented blend of citrus polymethoxylated flavones (PMFs) and tocotrienols has been clinically shown to promote cardiovascular health by supporting normal cholesterol production by your liver, helping balance triglyceride production, and providing powerful antioxidant protection. The PMFs promote normal cholesterol levels by inhibiting both the production of cholesterol precursors, such as cholesteryl esters, and the activity of HMG CoA Reductase, an enzyme that synthesizes cholesterol in the liver. These PMFs can also balance the body’s production of triglycerides by inhibiting your liver’s triglyceride producing enzyme, diacylglycerol acetyltransferase. Tocotrienols help break down cholesterol building blocks, interfere with cholesterol production, and provide critical antioxidant protection. Because cholesterol becomes problematic when oxidized, the powerful antioxidant action of tocotrienols can help prevent the conditions that may affect your cardiovascular circulation.

Spearheading the Wellness Revolution in Cholesterol Defense

With so many ways to develop undesirable cholesterol levels in your body, you need to be proactive in maintaining your good health. In our on-going dedication to your wellness, and a commitment to delivering the benefits of our high quality supplements to the natural products marketplace, Source Naturals has produced a scientifically formulated blend of three effective ingredients in fighting unwanted cholesterol. Combining a comprehensive formula of allnatural components, clinically researched for promoting cardiovascular health, CHOLESTEROL RESCUE is available now at your local health food store.

References
Guthrie N, Kurowska EM. Anticancer and Cholesterol-lowering activities of citrus flavonoids. Handbook of Nutraceuticals and Functional Foods. (Wildman, R.E.C., ed), CRC Press, Boca Raton, FL. 2001. 113-126. Packer L, Weber SU, Rimbach G. Molecular aspects of alphatocotrienol antioxidant action on cell signaling. Symposium: Molecular Mechanisms of Protective Effects of Vitamin E in Atherosclerosis. American Society for Nutritional Sciences. 2001. 131:369S-373S. Hicks KB, Moreau RA. Phytosterols and phytostanols: functional food cholesterol busters. Food Technology. 2001. 55:63-67. Middleton Jr E, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Review. 2000. 52:673-751. Child P, Kuksis A. Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro. Journal of Lipid Research. 1983. 24: 1196-1209

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Vitanet ®

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Date: June 25, 2005 07:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: All Calories Are Not Created Equal

All Calories Are Not Created Equal

When we eat more than our daily energy requirements (and most of us do), the extra energy is stored as fat. The human body is designed to stockpile fat very easily. This tendency is related to innate mechanisms intended to protect us against starvation or the threat of a diminished food supply. Fat cells provide extra fuel which can be utilized if necessary to sustain life. Those survival fat pounds settle on the hips, waist, thighs, upper arms and back, not to mention around organs, like the heart and kidney. Some ethnic groups, whose ancestors repeatedly suffered from famines, are especially efficient in energy storage. These include the Pima tribe48 in the United States, the Aborigines of Australia,49 and many of those of African descent.41

Fats are very readily converted to pounds. Carbohydrates and proteins require more complicated digestive processes to convert and store their energy than fat does. Calories from carbohydrates and proteins are usually burned and thrown off as heat (thermogenesis). Naturally, overeating proteins and carbohydrates can result in weight gain, however the body has to work harder to convert these nutrients to fat stores. It takes 20 to 25 percent of the energy in carbohydrate and protein to convert them into body fat. It only takes about 5 percent of the energy content of dietary fat to store it as body fat. Fat is also twice as energy dense (9 calories per gram) as carbohydrates or proteins (4 calories per gram) making fat at least twice as dangerous from a weight gain standpoint.50 Blood taken from an individual soon after they have eaten a double cheeseburger, french fries and a thick milk shake will often be a milky pink color due to the infusion of fat from the digestive system. This fat circulates throughout the system until it is either burned or stored.

A Winning Combination

Most people would agree that exercise combined with a low-fat, high-fiber diet would be a winning combination for maintaining and improving health. Exercise is important in any health maintenance program. It is especially important in weight control since the amount of energy we expend in the resting state, our Resting Metabolic Rate (RMR), is a function of our muscle mass and tone.51,52 There is a tendency for us to lose muscle mass and gain fat pounds as we age. In part, this is due to life style changes. Instead of flying kites we fly desks! Nevertheless, our capacity to increase our muscle mass is undiminished with age.53 The lack of exercise rather than the abundance of candy is thought to be the primary cause of childhood obesity.54

Eating a low-fat, high-fiber diet will produce some weight loss even in nor-mal weight subjects.55 The reason for this may well be the balance between fullness and satiety.56 It is a proven fact that we can easily eat an excess of fat before we feel full or satisfied. This is because fats are twice as energy dense (9 calories/ gram) as carbohydrates or proteins (4 calories/gram). By the time we are full, we have over eaten. Increasing our fiber intake helps us feel full. (Of course expensive gastric bypass surgery is another alternative.57) Eating a highfiber diet helps us to feel more than just full. Low-fat, high-fiber diets are found to lead to a general lowering of cancer rates.58 Though the above combination of exercise, low-fat, and high-fiber may work in theory; making the theory work in practice is quite another story.

Technology works against us in some ways as evidenced by this comment a woman made about her husband’s physique: “He has added 20 pounds of lap since he got his lap-top [computer].” And just try to get a low calorie meal over your lunch hour. In Feburary 1996 McDonald’s, an international fast food franchise, announced that it would be dropping its five-year experiment with the low-fat McLean burger (12 grams of fat). Also gone from the menu will be the Chef’s salad and the side salad. The taste of the Big Mac (35 grams of fat) has apparently won out over its McLean competition. The salads seem to be a casualty of convenience. Eating a salad in the car after a quick pickup at the drivethrough can be a bit challenging.

Fortunately, state-of-the-art research in the area of weight loss has discovered that through the addition of certain supplements and nutrients, the process of decreasing the amount of fat we process in the stomach and boosting the amount of fat we burn can be expedited. For those of us who suffer from a “fat imbalance” or a condition where we store more fat than we burn, it is often a matter of life or death to lose fat in order to protect our arteries and heart.

The Secret t o Weight Loss . . . An Ounce of Prevent ion Most weight-reducing strategies have to confront the “after the fact” problem of burning already stored fat. Like most of our medical practices, we routinely become sick or fat and then go about the business of trying to remedy our ills. Despite Poor Richard’s advice that “an ounce of prevention is worth a pound of cure,” we continually eat high-fat diets, and wait until we have to pay the piper before most of us take serious action. It’s much easier to prevent a fat build-up than to reverse the damage that carrying extra fat stores can cause. Going on a diet is nothing less than torture and usually means giving up all the foods we like to eat. Yet dieting seldom gets to the root cause of our excess weight which most often is that we eat too much fat, when not dieting. The body begins to digest lipids in the stomach and intestines.

The diagram in Figure 1 illustrates the steps involved in getting fat into our bloodstream.59 There are four steps in fat digestion: 1) acidolytic breakdown of food in the stomach; 2) enzymatic breakdown (lipolysis) of the fats (triglycerides, TGs) into fatty acids (FAs) and beta-monoglycerides (b-MGs); 3) formation of soluble mixed micelles with bile acids; and 4) absorption through the intestines. If we could tie up excess fat before it was absorbed, we could spare our physiological systems the stress of having to deal with that fat. Ideally then, what we need is a substance that prevents fat absorption.

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Date: June 25, 2005 10:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HISTORY

HISTORY

Ginkgo has achieved unprecedented popularity within the last decade and has become a familiar household term. Because interest in treating diseases like Alzheimer’s has escalated over the last decade, the biochemical capabilities of ginkgo in regard to brain function have been investigated and are still being researched. Ginkgo is one of those herbs that has become intrinsically connected with notions of herbal elixirs capable of pre s e rving youth and promoting longevity.

Ginkgo comes from the oldest species of tree in the world dating back some 200 million years. Some ginkgo trees have been known to live well over an average of 1000 or more years. The ginkgo tree is also known as the “maidenhair tree” and would have probably become extinct if the trees had not been cultivated in Far Eastern temple gardens and nurtured by Oriental monks.

Ginkgo is a deciduous conifer with separate male and female types. It resembles the pau d’arco tree and like pau d’arco, possesses an unusual immunity to insects and diseases. Ginkgo’s remarkable hardiness enabled it to survive the atomic blast at Hiroshima. Because of its unprecedented longevity, ginkgo biloba has sometimes been referred to as a living fossil.

Ginkgo has been used in China for over 5000 years. The Chinese refer to the fruit of the ginkgo tree as pa-kwo. This fruit is sold in markets throughout China and resembles dried almonds. Ginkgo fruit is pleasant tasting when fresh, but can become quite disagreeable if allowed to get overly ripe. Asians have relied on extracts of the fan-shaped ginkgo leaf since 3,000 B.C. to heal a wide variety of ailments.

The Chinese have been acquainted with the curative powers of ginkgo for centuries and have typically used the herb for ailments related to aging, such as circulatory disorders, mental confusion and memory loss. In China, ginkgo seeds, called baigou, are considered lung and kidney tonics and are used in conjunction with acupuncture. Ginkgo seeds also help to tonify the urinary system, so they are used in cases of incontinence and excessive urination.1

Practitioners of Chinese medicine routinely use ginkgo leaves. Ginkgo was introduced into Eu rope in 1730 and was we l l received, not for its medicinal value, but for its ornamental appeal. It is used extensively in landscaping because of its lovely fern-like leaf. It was brought to America in 1784 to the garden of William Hamilton who lived in Pennsylvania.

Decades passed before the healing properties of ginkgo we re investigated. Consequently, it has been part of the herbal repertoire only since the 1980s. During this time, it became technically feasible to isolate the essential components of ginkgo. Pharmacologically, there are two groups of substances which are significant compounds found in ginkgo: the flavonoids, which give ginkgo its antioxidant action, and the terpenes, which help to inhibit the formation of blood clots. The majority of scientific interest has focused on Ginkgo’s ability to improve the circulation of blood. O ver the past twenty years, scientific testing on the plant has dramatically escalated. Ha rva rd professor Elias J. Core y, Ph . D , synthesized ginkgo’s active ingredient, ginkgolide B, for the first time in the laboratory. Consequently, stepped-up research in this country and in Eu rope resulted. Ginkgo has been the subject of over 300 scientific studies and continues to intrigue scientists. Much modern research has confirmed ancient applications of ginkgo as well as discovered new ones.

Ginkgolide, the active component of the herb, is what creates most of ginkgo’s biochemical attributes. Exactly how ginkgolide B functions is not yet known. One theory is that the compound somehow interferes with a chemical found in the body called PAF (platelet activating factor). PAF has been implicated in cases of graft rejection, asthma and other immune disorders. PAF antagonists have been identified from a variety of medicinal plants. These compounds help to explain the pharmacological basis of several traditional medicines and provide a valuable new class of therapeutic agents.

Particular attention has been paid to ginkgo’s powerful actions on the cardiovascular system. Thousands of Europeans use this herb for peripheral circulatory disorders. As a circulation booster, ginkgo has accumulated some impressive credentials. Because proper circulation is vital to each and every body function, virtually all body systems can benefit from ginkgo therapy.

Ginkgo’s relationship to brain function has also spawned considerable interest. In 1985, Rudolf Weiss said of ginkgo,

“ Significant improvement in mental states, emotional lability, memory, and the tendency to tire easily, have been reported.”

Ginkgo is currently planted in groves and used for a number of medicinal purposes. It is harvested in the summer and can be used in extract, tincture or infusion forms. The therapeutic properties of ginkgo seem endless. Continuing re s e a rch promises to further uncover additional health benefits of this remarkable botanical. Ginkgo extracts are among the leading prescription medications in France and Germany. Currently, millions of prescriptions for ginkgo are written by physicians worldwide.

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Date: June 24, 2005 03:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cancer and Echinacea

Cancer and Echinacea

Some experts believe that over the last 40 years, science has lost its battle with cancer. Progress has been slow and cancer mortality rates continue to rise despite the enormous amount of money spent on research. While most of us are aware of potential carcinogens which surround us at every turn, most of us do not take a preventative approach.

In other words, even if we eat nutritiously and try to protect ourselves from toxin exposure, cancers still develop. The role of the immune system in cancer pre vention is significant to say the least. Why some people develop cancerous tumors and others do not may be linked to immune function.

We’re all aware of the new emphasis on antioxidants today. Likewise, stimulating and strengthening the immune system may also provide significant protection against certain types of malignancy. It’s time to concentrate on why some of us don’t get cancer instead of focusing all our attention on why some of us do.

In addition to boosting the immune system, echinacea has been shown to increase pro p e rdin levels in the body which may be responsible for its anti-cancer activity. By increasing the production and secretion of interferon, echinacea may help enable the body to neutralize carcinogens.15

USDA researchers have found that echinacea contains a tumor inhibiting compound. This compound is an oncolytic lipid-soluble hydrocarbon. This particular substance which is found in the essential oil of echinacea, has shown its ability to inhibit lymphocytic leukemia and other types of cancers.

One theory concerning this activity is that it probably does not involve creating a cytotoxic effect directly on cancer cells, but rather stimulates the action of anti-cancer cells such as natrual killer cells already present in the body.

The fact that echinacea inhibits the enzyme, hyaluronidase may also be a factor. The same type of mechanism that breaks down the protective barrier around cells so that disease microbes can enter is thought to occur in the initial stages of tumor formation. Because echinacea prevents the formation of hyaluronidase, it may play a role in preventing the development of certain types of cancer.16

Allergies and Echinacea

German research has demonstrated echinacea’s ability to treat certain allergic reactions.17 It may be the cortisone-like activity of echinacea which accounts for its anti-inflammatory action. In the case of allergic reactions, the immuno-suppressive action of echinacea kicks in.

An allergy occurs when the immune system becomes overly stimulated by the presence of an allergen. Each time that the allergen enters the body an allergic response is initiated. Echinacea can temper this cascade of symptoms by stabilizing mast cells, which are responsible for the histamine release which creates havoc with our bodies. This action results in a substantial reduction of allergy symptoms.

The fact that echinacea actually suppresses the immune system is nothing less than remarkable. This herb might be referred to as “the botanical with a brain.” In other words, it can either stimulate or inhibit immune response as determined by the status of the body. Synthetic drugs do not have this ability.

Healing Stimulation by Echinacea

Because echinacea has antiseptic pro p e rties, it can be used both internally and externally to heal conditions such as bed sores, boils, burns, ulcers and wounds of any kind. The inulin Echinacin B content of echinacea extracted from the rhizome gives echinacea its wound healing pro p e rties. It also accelerates the production of granulomatous tissue which is necessary for tissue healing in the body. 18

Russian studies have shown that echinacea also helps to stimulate healing in wounds and prevents blood clotting.19

Chronic Fatigue Syndrome and Echinacea

Because echinacea contains the polysaccharides inulin and echinacin it may be helpful in fighting stubborn viral infections such as Chronic Fatigue Syndrome. Anytime the immune system becomes c o m p romised due to exhaustion, allergies, or depression, viral and bacterial invasion can occur. The chemical compounds contained in echinacea promote improved resistance to all septic or infectious conditions.20

Prostate Disorders and Echinacea

Echinacea is believed to be one of the best herbs in the treatment of enlarged prostate glands or other prostate disorders .21 Its anti-inflammatory properties are believed to help decrease swelling and irritation. Tests on mice have shown that using echinacea to control inflammatory responses has resulted in a decrease in edema or swelling.

Weight Loss and Echinacea

When combined with chickweed, echinacea has been used to promote weight loss.22 Scientifically, there is a lack of data to explain this particular effect.

Echinacea and Skin Damage

Any type of skin damage, whether caused by injury or infection can be treated with echinacea. One of the major actions of this herb is its ability to inhibit a specific enzyme that weakens connective tissue cells when they are exposed to certain microorganisms. This enzyme is called hyaluronidase .23 Whenever skin cells have been compromised by infectious organisms, echinacea can help prevent the spread of infection and speed the healing of the skin by preventing the break down of skin tissue at the cellular level. The anti-hyaluronidase action of echinacea, especially when applied as a poultice, can significantly prevent infection and enhance healing in burns, cuts, and abrasions.

In addition, topical applications of echinacea are valuable in treating snake and insect bites. German research suggests that echinacea extracts and salves can benefit a variety of inflammatory skin conditions including: psoriasis, eczema, and herpes.24

Yeast Inf ect ions and Echinacea

Yeast infections are caused by an fungus called Candida albicans. This particular organism has been the subject of intense interest, research and controversy over the last several years. Standard medical therapies for yeast infections usually involve the use of antibiotics and antifungal drugs which can, in themselves, compromise the immune system. In laboratory tests using control groups, subjects who received echinacea we re compared to those who took standard antifungal treatments. In these cases, better results we re obtained with the echinacea.25 It is the polysaccharides contained in echinacea which seem to enhance the resistance of the immune system against the Candida fungus. This finding again stresses that echinacea may have important therapeutic applications for anyone who is in a weakened state and susceptible to opportunistic infections.26 Echinacea in both external and internal forms can be used to treat yeast infections. It has been suggested that anyone who has recurring yeast infections should consider adding echinacea extract to their repertoire of health supplements.

Inflammation, Arthrit is and Echinacea

Some laboratory tests have demonstrated that echinacea has certain anti-inflammatory pro p e rties which can help prevent or decrease the inflammation and swelling typically found in arthritis sufferers. Unlike the inflammatory response of the body to infections, the chronic inflammation of joint diseases such as arthritis is not desireable. In these cases, echinacea can help to inhibit chronic inflammation. Its effect is considered equal to approximately half of that resulting from steroid drugs like cortisone in arthritic patients.27

Apparently, echinacea contains a specific factor which prevents inflammation and swelling when observed in certain laboratory tests. This particular tonic action may be quite helpful for people who suffer from chronic arthritis. Arthritis symptoms result from an immune response which creates inflammation in the joints. As is the case with allergies, when arthritis is present, echinacea inhibits the inflammatory action of the immune system.

It is interesting to note that another component of echinacea actually boosts the inflammatory response when it is appropriate. For this reason, wounds respond well to echinacea.

Steroids are commonly prescribed for inflammatory diseases such as arthritis. Because steroid drugs have so many negative side-effects, echinacea may prove to be an invaluable treatment for improper immune system reactions that cause conditions like arthritis.

HIV and Echinacea

At this writing, the possible role of echinacea on HIV has not been established. While some preliminary studies look promising, much more research is needed to determine whether or not echinacea’s stimulation of immune function will benefit AIDS patients.

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Date: June 24, 2005 01:31 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Infections Respond to Echinacea?

What Infections Respond to Echinacea?

Echinacea extracts are excellent when used for various kinds of acute infections. Colds and throat infections seem particularly vulnerable to the immunostimulant action of echinacea. Infections such as influenza and strep are also affected by the herb. Again, taking echinacea on a regular basis does not guarantee that the body will not develop an infection, howe ve r, the duration and seriousness of the infection should be decreased.

Antibacterial Action of Echinacea: It is interesting to note that echinacea renders a mild effect on bacteria. It must be remembered, however, that the ability of echinacea to stimulate the immune system may explain its long historical use for bacterial infections. The echinacoside and caffeic acid content of echinacea have been found to inhibit the growth of bacteria such as Staphylococcus aureus, Corynebacterium diphtheria and Proteus vulgaris. 13

Viral Infections and Echinacea : Viral infections are notoriously difficult to treat. Even with all the strides that medical technology has made, finding a cure for viral disease has remained elusive. Echinacea stands out as one of the more effective antiviral herbals. The plant has undergone several studies to determine what exactly makes it an effective virus fighter. Se veral studies have confirmed that when certain laboratory samples were pre-treated with echinacea compounds, they became protected against exposure to several viruses including: influenza, herpes and vesicular stomatitis (canker sores).

Scientists believe that the polysaccharides contained in echinacea called inulin are primarily responsible for the immuno-stimulant effect of this herb. The following listed actions make echinacea especially effective in fighting viral infections and cancero u s conditions.

•. Promotes macrophage activity
•. Stimulates T-cell production
•. Stimulates interferon production
•. Increases phagocytosis 14

It is echinacea’s ability to stimulate T-cell activity, that subsequently produces interf e ron which may be responsible for its anti-viral effect. While this theory has been disputed, ingesting certain forms of echinacea has resulted in some degree of protection against viral infection. Fresh echinacea juice appears to be the most effective form of the herb.

In any case, research strongly suggests than anyone who consumes echinacea regularly can expect protection against some viral infections to a certain degree.

Respiratory System Infections and Echinacea: Echinacea has become well known for its ability to treat respiratory infections including: influenza, tonsillitis, whooping cough, and colds. In addition, bronchial and ear infections respond well to echinacea therapy. The majority of research that supports this action of echinacea was done in Europe with injectable forms of echinacea which are not legal here.

Using whole, powd e red, capsulized echinacea on a daily basis during the winter months may also provide significant protection against these respiratory diseases. Concentrated liquid extract is also recommended.

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Date: June 22, 2005 09:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does CLA Work?

How Does CLA Work?

How could CLA hinder the growth and development of certain cancers in animals? Scientists have developed some intriguing possibilities, and many of them are related to the theory of antioxidants.

WHAT IS AN ANTIOXIDANT?

Well, one of the ironies of life is that oxygen, so essential to human life, also causes decay. Look at the parts of your car where paint may have pealed away, and you will notice rust, what scientists call oxidation. Molecules of oxygen combine with the iron or chromium on your car and change its chemical alignment to iron oxide or chromium oxide—rust. In a very real sense, the same thing happens to you as you age. Inside your cells, thousands of chemical reactions take place each moment. These reactions break apart the long chains of carbon, oxygen and hydrogen that make up body tissues and combines them in new ways. Some of those combinations cause decay. One example is when a free radical—a single atom of roaming oxygen—attaches itself to something useful, rendering it useless or even dangerous. If a free radical were to change DNA, for example, that could mutate a cell. This free radical process is one way this oxidation occurs, and antioxidants, often called free radical scavengers, attach themselves to the free radicals, blocking their damage. This can help improve life and help to cut the problems of oxidation. Indeed, many see antioxidants as a way of lessening the risks of cancer.

Many people know about important antioxidants, such as ascorbigen (vitamin C), selenium or alpha tocopherol (vitamin E), but nature provides numerous antioxidants. Many exciting ones are emerging, such as proanthocyanidins (often known as pycnogenol), quercetin (common in many fruits) and selenium (a mineral). C LA may be another antioxidant emerging from the research. Dr. Pariza and others found in a 1991 experiment that in the test tube, CLA was effective in battling free radicals. 28 It helped prevent damage to the DNA inside the cells. Pariza says in another paper, “Our hypothesis is that the antioxidant activity of CLA may at least in part explain its anticarcinogenic effect.”29 That would mean that one way CLA prevents cancer is because it blocks these dangerous free radicals. (Other theories about how it fights cancer include breaking down the chemicals that cause cancer into others that don’t .30 All the theories may be true in specific situations, and none might.) But like many other emerging, exciting areas of scientific inquiry, this idea that CLA is an antioxidant has doubters. Researchers J.J. van den Berg, N.E. Cook and D.L. Tribble wanted to see if CLA protected fatty membranes comprised of a substance called palmitoyl-2-linoleoyl phosphatidylcholine (PLPC) from the damage of biologic oxidation. In research published in 1995, they compared CLA’s effect to the wellknown antioxidant vitamin E. While vitamin E protected well, CLA did relatively little. They also found that CLA did not become a mineral chelator, an agent that helps natural minerals become available biologically. They bluntly said, “On the basis of our observations, a role for CLA as an antioxidant does not seem plausible.”31

Another study in 1995, however, showed that CLA can break down into other substances, called feran derivatives, that do act as antioxidants.32 As in all emerging sciences, debates ensue among honest, dedicated researchers. CLA may not, itself, be a antioxidant. Perhaps it acts as antioxidant in only certain situations. Perhaps things that come from CLA act like antioxidants. That is the state of the research today. (Indeed, Dr. Pariza says such debates are common in the field of antioxidants. 33)

What is important to remember is that in numerous animal models, CLA protected against the dangers of many different kinds of cancer in animals, and that, according to scientists, it is one of the most potent cancer-preventing substances of its kind known to science. Whether the cause of this effect was because of CLA or because of some other reason really isn’t that important.

Another thing to remember is that CLA is not a cancer drug. It is something that would be useful in addition to other cancer treatments. It is something to consider to lower your risks and, perhaps, lessen the effects of treatment. It should not be considered a treatment option on its own.

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Date: June 18, 2005 09:07 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Anti-Aging Nutrients

Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling.

How Do We Age?

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents.

Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do?

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460).

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs.Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems.

In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less.

And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.

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Vitanet ®

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Date: June 14, 2005 05:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: America's Most Wanted

America's Most Wanted

by Brian Amherst Energy Times, January 6, 2000

The United States eats well, a little too well, according to experts. Amply supplied with a large supply of high-calorie food, our diets might seem to be chock full of every conceivable nutrient. Well, to the question "Getting all the right vitamins, minerals and other nutrients?" the most appropriate answer seems to be "Not exactly." Eating a lot doesn't equal eating a lot of the most important vitamins and minerals. So, which vitamins and minerals are likely to show up in short supply in the typical American diet? Calcium certainly sits at the top of list. According to the most recent Continuing Survey of Food Intake by Individuals, which is conducted by the United States Department of Agriculture (USDA), women and girls age 12 and up are not consuming adequate calcium from their diet. Research reveals that about 1200 mg. day suffices for those over age 50 and 1000 mg a day should be adequate if you're between the ages of 19 and 50. Since strong bones are formed during "the first three decades of life," says Laura Bachrach, MD, of Since strong bones are formed during "the first three decades of life," says Laura Bachrach, MD, of Stanford University, ". . .osteoporosis is a pediatric disease." For long-range protection against that bone-weakening disease, kids should eat calcium-rich, low-fat dairy products and plenty of leafy greens (broccoli, cabbage, kale) as well as salmon (with bones), seafood and soy. But the calcium campaign does not end in early adulthood. Bone mass begins to deteriorate at about age 30. Menopausal hormonal changes can exacerbate bone brittleness. Medical conditions, including cancer, liver disease and intestinal disorders; prescription drugs; tobacco and alcohol indulgence; or a decline in activity, especially the weight-bearing kind, also jeopardize bone strength. According to the National Osteoporosis Foundation, about one in every two American women will break a bone after age 50 due to osteoporosis. That translates into about half a million fractured vertebrae and more than 300,000 shattered hips. Frequently, those breaks are life-threatening.

Crucial Calcium

The critical role of calcium in many body functions is perhaps the most extensively clinically documented among nutrients. Researchers in the Department of Medicine, Oregon Health Sciences University in Portland, reviewed epidemiological and clinical studies conducted over the past two years on the relationship between dietary calcium and blood pressure (J Am Coll Nutr October 1999: 398S-405S). "Nearly 20 years of investigation in this area has culminated in remarkable and compelling agreement in the data," the researchers report, "confirming the need for and benefit of regular consumption of the recommended daily levels of dietary calcium." Investigators at the State University of New York, Buffalo School of Dental Medicine, presented results of their studies of calcium and vitamin C and gum disease at the June 26, 1998 meeting of the International Association for Dental Research. Two separate inquiries revealed that people who consumed too little calcium as young adults, and those with low levels of vitamin C in their diets, appear to have nearly twice the risk of developing periodontal disease later in life than folks with higher dietary levels of either nutrient.

Calcium: Much Documented Researchers offer extensive evidence of calcium's benefits on many fronts: n Osteoporosis poses a threat to older men as well as women, according to Randi L. Wolf, PhD, research associate at the University of Pittsburgh Graduate School of Public Health. Dr. Wolf presented her award-winning study to an October 3, 1999 meeting of the American Society for Bone and Mineral Research. Dr. Wolf suggests that men increase their consumption of calcium, particularly after age 80, to avoid age-related declines in the amount of calcium absorbed. According to Dr. Wolf, "It appears that the hormonal form of vitamin D, which is the main regulator of intestinal calcium absorption, may have an important role. We are conducting more research to better understand the reasons for why calcium absorption declines with age in men." n Scientists at Tufts University in Boston did some earlier work on the calcium-vitamin D connection and reported it in the September 4, 1997 New England Journal of Medicine. Using the National Academy of Sciences (NAS) increased recommended daily intake of 1200 milligrams of calcium and 400 to 600 international units of vitamin D for people over 50, the Tufts researchers found that with supplementation of the nutrients, men and women 65 and older lost significantly less body bone and, in some cases, gained bone mineral density. n Two studies published in American Heart Association journals show that atherosclerosis and osteoporosis may be linked by a common problem in the way the body uses calcium. The September 1997 Stroke revealed that, in a group of 30 postmenopausal women 67 to 85 years old, bone mineral density declined as atherosclerotic plaque increased. Researchers reporting in Circulation (September 15, 1997) advanced the theory that the osteoporosis-atherosclerosis connection may be related to a problem in handling calcium. n For people who had colon polyps removed, taking calcium supplements decreased the number of new polyps by 24% and cut the risk of recurrence by 19%, according to researchers at the University of North Carolina, Chapel Hill, School of Medicine. The study, published in the January 14, 1999 New England Journal of Medicine, was a first in crediting calcium with anti-cancer properties.

The D Factor

Without adequate vitamin D, your absorption of calcium slips and bone loss can accelerate, increasing the risk for fractures. Fifty percent of women with osteoporosis hospitalized for hip fractures at Brigham and Women's Hospital in Boston had a previously undetected vitamin D deficiency (Journal of the American Medical Association, April 28, 1999). University of Pittsburgh Cancer Institute researchers told participants at the April 14, 1997 meeting of the American Association for Cancer Research that vitamin D "significantly inhibits highly metastatic, or widespread, prostate cancer in animals," suggesting its potential for treating men with similar conditions. Few foods that Americans eat, except dairy, contain much vitamin D, but we can usually synthesize sufficient amounts from as few as five minutes' exposure to the sun. But as skin ages, its ability to act as a vitamin D factory decreases. According to Michael F. Holick, the director of the Vitamin D, Skin and Bone Research Laboratory at Boston University Medical Center, upwards of 40% of the adult population over age 50 that he sees in his clinic are deficient in vitamin D. Recently, the National Academy of Sciences (the official body that decrees the required amounts of necessary nutrients) increased the daily recommendations of vitamin D to 600 IU for people over 71, 400 IU for those aged 51 to 70 and 200 IU for people under 50. The best dietary sources, apart from dependable supplements, are dairy and fatty fish like salmon. Four ounces of salmon provide about 300 IU.

The Facts About Fats

The American lust for low-fat, high-carbohydrate diets filled with sugary foods has exploded into nothing short of "obsession," according to experts at the General Research Center at Stanford University Medical Center (Am J Clin Nutr 70, 1999: 512S-5S). That mania oftens robs us of the crucial balance of omega-3 and omega-6 fatty acids typical of the Mediterranean diet that protect us from heart disease by controlling cholesterol and making blood less likely to form clots. These fatty acids cannot be made by the body but are critical for health: n Omega-3 fatty acid (linolenic acid) comes from fresh, deepwater fish (salmon, mackerel, sardines) and vegetable oils such as canola, flaxseed and walnut. n Omega-6 fatty acid (linoleic acid) found primarily in raw nuts, seeds and legumes and in saturated vegetable oils such as borage, grape seed, primrose, sesame and soybean. The American Heart Association recommends limiting total fat consumption to 30% of daily calories. Saturated fats like those in dairy and meat products as well as vegetable oil should comprise 10% of total calories; total unsaturated fat (fish oils, soybean, safflower nuts and nut oils) should be restricted to 20 to 22% of daily calories.

Be Sure About B12

Vitamin B12 presents a particular problem for the elderly because older digestive systems often don't secrete enough stomach acid to liberate this nutrient from food. (The elderly have no problem absorbing B12 from supplements, because it's not bound to food.) Vitamins generally moderate the aging process but, ironically, that process and the diseases that frequently accompany it affect vitamin metabolism (Schweiz Rundsch Med Prax 83, 1994: 262-6). And because of those changes, we need more of certain vitamins. This is the case for vitamins D, B6, riboflavin and B12. Crucial for health, B12 is necessary to prevent anemia, and, according to recent studies, needed (along with folate and B6) to help stave off heart disease. B12, with thiamine and niacin, boosts cognition (Adv Nutr Res 7, 1985: 71-100). Screening for vitamin B12 deficiency and thyroid disease is cheap and easy and can prevent conditions such as dementia, depression or irreversible tissue damage (Lakartidningen 94, 1997: 4329-32). In the January 5-12, 1999 issue of Circulation: Journal of the American Heart Association, the AHA urged doctors to screen levels of homocysteine (the amino acid byproduct of protein digestion that damages arteries, causes heart disease and, possibly, strokes) in patients at high risk for heart disease. They also recommended all Americans to up their daily levels of vitamins B6 and B12, as well as folic acid. Since fruits, vegetables or grains lack B12, vegetarians need B12 supplements. And they're a good idea for the rest of us, too.

Folic Acid Benefits

Folic acid made headlines in the early 1990s when the U.S. Public Health Service declared that "to reduce the frequency of neural tube defects [spina bifida, or open spine, and anencephaly, a lethal defect of the brain and skull] and their resulting disability, all women of childbearing age in the United States who are capable of becoming pregnant should consume .4 milligrams (400 micrograms) of folic acid per day." This recommendation followed voluminous research that showed taking folic acid was associated with a significantly reduced risk of birth defects. (The advisory is based on the fact that nearly half of all pregnancies are unplanned. If you think you are pregnant, consult your health practitioner for supplementary advice.)

A Team Player

Folic acid's efficacy intensifies when it works with other nutrients. Among many studies on the preventive powers of folic acid on birth defects, one published in The New England Journal of Medicine (327, Dec. 24, 1992: 1,832-1,835), disclosed an even greater decrease in neural tube defects when supplements of folic acid contained copper, manganese, zinc and vitamin C. As a warrior against homocysteine, folic acid joins the battalion of B12 and B6 in detoxifying this harmful protein. At the University of Washington's Northwest Prevention Effectiveness Center, researchers recently analyzed 38 published studies of the relationship between folic acid, homocysteine and cardiovascular disease and, according to associate professor Shirley A. Beresford, MD, folic acid and vitamin B12 and B6 deficiencies can lead to a buildup of homocysteine.

Compelling Evidence

Canadian researchers reported in the Journal of the American Medical Association (275, 1996: 1893-1896) that men and women with low folic acid have a 69% increase in the risk of fatal coronary heart disease. This 15-year study of more than 5,000 people stressed the need for dietary supplementation of folic acid. Folic acid also has been credited with the potential to protect against cancers of the lungs, colon and cervix. It appears to help reverse cervical dysplasia, the precursor cells to cervical cancer, especially for women taking oral contraceptives, which may cause a localized deficiency of folic acid in the cells of the cervix. According to Shari Lieberman, PhD, and Nancy Bruning, authors of The Real Vitamin & Mineral Book (Avery), folic acid derivatives work with neurotransmitters, the chemicals that permit signals to be sent from nerve fiber to nerve fiber. A lack of folic acid can cause some nervous-system disorders, such as depression, schizophrenia and dementia; it also may be related to some forms of mental retardation. Other supporting roles of folic acid, according to researchers: the formation of normal red blood cells, important for preventing the type of anemia characterized by oversized red blood cells; strengthening and improving white blood cell action against disease; limiting production of uric acid, the cause of gout.

The Best Sources

Many foods are rich in folic acid: beef, lamb, pork and chicken liver, spinach, kale and beet greens, asparagus, broccoli, whole wheat and brewer's yeast. But experts believe that only 25 to 50% of the folic acid in food is bioavailable. Processing also reduces an estimated 50 to 90% of its content. Folic acid supplementation overcomes these obstacles with little risk, as it has no known toxicity. Women taking folic acid who are current or former users of oral contraceptives may require additional zinc. And be sure to augment your folic acid supplement with its synergistic counterpart, vitamin B12.

Focus on Fiber

The American Heart Association came out squarely behind fiber in a June 16, 1997 issue of its journal Circulation: Double your daily intake to lower cholesterol and the risk of heart disease. The American diet is consistently low in fiber, notes Linda Van Horn, PhD, RD, author of the article. Twenty-five to 30 grams a day from foods (or supplements) are not only heart healthy but seem to aid weight control.

Iron Problem

Getting enough iron? An estimated 25% of adolescent girls in the United States are iron deficient, according to an October 12, 1996 issue of the British medical journal The Lancet, which reported that girls who took iron supplements performed significantly better on verbal tests than those who took a placebo. "Teenage girls should be regularly tested for iron deficiency because rapid growth and the onset of menstruation during puberty increase the body's need for iron," says Ann Bruner, MD, of the Johns Hopkins Children's Center and a lead author of the study.USDA data reveal that women up to age 50 also tend to get much less than recommended levels of iron, a lack of which leads to anemia, a deficiency of red blood cells, hemoglobin or volume of blood. For kids, deficiency is more common from six months to four years and during the rapid growth spurts of adolescence when the body is growing so quickly that the body's iron stores may sink to dangerous levels. Vegetarian women run the greatest risk for deficiency, as meat is iron-rich; foods like beans, grains and vegetables also contain some iron. Supplements, of course, supply easily absorbable iron. And to absorb iron from vegetarian sources, take vitamin C with your meals. That boosts the amount of this mineral you will take in. Bear in mind, however, that certain folks-older men and post-menopausal women-generally have adequate dietary supplies of iron. Of greater concern, in fact, is excessive iron, and for these folks iron-free multivitamin and mineral supplements are available.

Ante Up the Antioxidants

Antioxidant nutrients help protect the body from oxygen-scavenging molecules called free radicals. The products of pollution, the body's own metabolic processes and other sources, free radicals are linked to heart disease, cancer and other chronic health problems. The most important antioxidants, which include vitamin C, E, beta carotene, and selenium, are often lacking in the American diet. Plus, optimal amounts of vitamin E cannot be consumed from food. You need supplements. The bottom line: even though we live in a land of plenty, you can still miss vital nutrients. So make sure to consume these vital substances.

Sprouts: Nutritional

Source of Missing Nutrients In the search for the nutrients missing from America's diet, one big help is the sprout. The sprout is truly one of nature's heavyweights: fresh, tiny and moist, its power punch of vitamins, minerals, protein, chlorophyll and disease-busting phytochemicals land it in a weight class far beyond that of its full-grown competitors. Size does NOT matter to this nutritional giant. A championship belt currently wraps around the miniscule broccoli sprout, catapulted into the ring by Paul Talalay, MD, professor of pharmacology and molecular sciences at Johns Hopkins University. Dr. Talalay discovered that the seedlings contain substantially more of the cancer-fighting substance sulforaphane than mature plants (Proc. Natnl. Acad. Sci. USA, 94, 10367-10372). Sprouts, the quintessential health food of the Sixties, provide a wonderfully varied and versatile way to get your daily greens. Raw or cooked, strong or mild, vegetable and grass sprouts and their algae cousins add low-calorie texture to recipes and a rich, diverse complement of nutrients and fiber.

Ancient Asia to the Modern Lab

Asians stir-fried sprouts as one of the earliest fast foods as long as 5,000 years ago. The ancient Chinese relied on sprouts for year-round vegetables in colder regions of their vast country. Today, researchers studying sprouts and adult plants have identified their important chemoprotective and other health-bolstering substances. In Paul Talalay's research project at Johns Hopkins, scientists found that three-day-old broccoli sprouts contain up to 50 times more sulforaphane than mature plants, which prompts the body to produce an enzyme that prevents cancer tumors from forming. Uniform levels of the compound saturate the shoots, unlike the chemically uneven adult plants. The Brassica family of broccoli and cabbage is richly endowed with phytochemicals that also help reduce estrogen levels associated with breast cancer. Other phytochemical compounds in the Brassica family are associated with the prevention of stomach and lung cancers. Most of the initial landmark work on phytochemicals' cancer-fighting powers has taken place since 1989 under the aegis of the National Cancer Institute's "Designer Food Program," which isolated, for example, the isoflavones in beans that seem to neutralize cancer-gene enzymes.

Strong Suit: Soy and Spirulina

The isoflavones and phytosterols in soy produce an estrogenic effect that appears to relieve menopausal symptoms and help prevent breast cancer. Soy foods expert Mark Messina, PhD, has done extensive work on the subject, some of which has been published in the Journal of the National Cancer Institute 83, 1991: 541-6. Researchers also have synthesized a bone-strengthening form of soy isoflavones called ipriflavone, following impressive clinical trials in the treatment of osteoporosis (American Journal of Medicine, 95 [Suppl. 5A] (1993): 69S-74S). Spirulina and other micro-algae are fascinating organisms that inhabit a niche between the plant and animals kingdoms. Named for its tiny spirals, spirulina, a blue-green algae, grows in saline lakes but is cultured for maximum nutritional content. In her book Whole Foods Companion (Chelsea Green), Dianne Onstad notes that spirulina contains "the highest sources of protein, beta carotene and nucleic acids of any animal or plant food." Its nucleic acids, she says, benefit cellular regeneration; its fatty acids, especially GLA and omega-3 acids, make it one of the most complete foods. Sprouts, like any other produce, should be rinsed thoroughly before serving. People at high risk for bacterial illness-young children, the very elderly or folks with weakened immune systems-should limit their consumption of raw sprouts. But no matter how you eat them, you may find more spring in your step from these tiny, sprouting nutritional wonders.

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Vitanet ®

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Date: June 13, 2005 07:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Best Bread ...

Best Breads by Jane Lane Energy Times, December 9, 1999

Few of us can resist the seductions of freshly baked bread, warm and fragrant, poised on the edge of a steaming bowl of soup or painted with an aromatic swath of rosemary scented oil. Even those of us from the most culinary challenged households can recall the pleasures of the simple plump white dinner roll or flaky biscuit piled in a basket on the dinner table.

Bread has blossomed from sideshow status beside the dinner plate to a full-scale mealtime headliner, a scrumptious star enriched by nutritious grains, herbs, fruits and vegetables.

Contemporary cooks build meals around crunchy cornbread or chewy focaccia, presenting soups or salads as satisfying counterpoints. Want to jump into the bread baking basket or hone your skills? Two top vegetarian chefs shared with Energy Times their passion for bread and their expertise in baking. See if you don't find that ardor contagious.

Nancy Lazarus is a chef at the famed Moosewood Restaurant in Ithaca, New York, established in 1973 to serve up natural fare with a homecooked, vegetarian emphasis. The bill of fare changes daily at Moosewood, but there's one constant: a cup or bowl of soup, a salad and a thick slice of bread. Some loyal customers have ordered the daily special for 20 years.

That's why bread occupies a cherished spot at Moosewood. Nancy Lazarus tells why and offers some of Moosewood's favorite bread recipes: "Cooking is like art; baking is like science; bread is like magic. No matter how much science you apply, you'll never have complete control: It'll do its own thing on some level, which is part of its charm, if you're charmed by that sort of thing. Breads come out differently depending on heat and humidity, the heat of the oven; yeast is a variable that can be slower or faster acting.

"There are bread machines, of course, and they work. But they're not as satisfying as the real thing, the kneading, which can be almost therapeutic, and the control over the ingredients to your own specifications.

"Bread is not that difficult. Know your own oven, to begin: Good insulation is important and how the heat travels around inside. Convection ovens are a wonderful thing.

"There are difficult breads we recommend you buy at a good bakery: baguettes, Italian, French and Cuban that are crusty outside and soft inside.

"But focaccia is easy. It's a yeasted bread that's better to make at home than buy because it's so fresh and you can control the toppings. It only requires one slow and one quick rising but you have to be there for a while.

"Then there are quick breads that use baking soda or powder, like cornbread. If you want a good meal at home and can make only one thing, make a quick bread. They're satisfying and delicious warm from the oven; and the aroma of bread fills the house. A corn bread with tomato soup for supper is a nurturing meal good for vegans.

"Popovers are fast and simple, a middle American 50s treat, but you do need a hot oven and 45 minutes. Also easy to make: sweet breads- carrot, banana, zucchini-and biscuits.

"To reduce the fat in denser quickbreads and cakes, use applesauce. It gives body and moistness.

"The number of wheat-sensitive people is rising dramatically. A theory I think makes sense is that in the last 30 years the varieties of wheat grown has been reduced to 1 or 2 that are more easily cultivated and harvested with the machinery available. People are overloaded with one type of wheat.

"Gluten is the offending substance in wheat and some oats; try rice, tapioca and potato flours, which are denser and more fine and don't produce a good crust. Improve the crust by baking in a preheated cast iron skillet.

"Also investigate chickpea flour. You don't make a loaf of bread with it- use it for flatbreads like papadam, which is in Indian cookbooks. And it's good for batter for vegetables.

"Spelt is the closest to wheat flour in consistency but some people can be sensitive to it.

"Visit a natural food store to check out the flours. The mills sometimes print handouts with recipes and a lot of those are real good, especially for what works with their flour. Or you may run into a baker who will whet your appetite with ideas and recipes.

"Bread is the supreme comfort food. It can speak to us, and reassure us. The magic of bread and how it varies: There's something appealing in that. In today's world, food is predictable, and that's reassuring to some people. At Moosewood, things are always different, and that's good."

Claire Criscuolo puts an intensely personal spin on the eclectically ethnic style of cooking at her esteemed vegetarian restaurant, Claire's Corner Copia. That 25-year-old institution in New Haven, Connecticut, reflects her zest for the freshest ingredients, robust flavors and inspired combinations. Claire, a teacher and advocate for healthful cuisine, pours her passion into her breadmaking as well:

"Healthy bread is like anything else-it has healthy ingredients. We use the best organic unbleached flour and yeast, pure vanilla, whole eggs (not dried and powdered), whole milk and organic sour cream. You want to use good, fresh ingredients. It's the essence of healthy cooking. "I tell my staff, 'Don't use your soup pot as a garbage pail. Bread is the same. If the ingredients aren't at their freshest for serving, then they aren't right for other uses in the kitchen.

"Our bread is very important at Claire's. We make a country white and a honey wheat in a pinwheel loaf-400 a day-and challah for the morning French toast with sauteed bananas or as buns for veggie burgers. "It's not practical to bake bread every day. We let our bread rise several times, punching it down again and again. For the home cook, it's time consuming. Even I'm happy to buy a good loaf of bread. "But anybody can bake bread. Combine flour, water and yeast and watch it grow! It's delights all your senses. And it a gratifies and satisfies. I was kneading it all by hand until we got up to 12 loaves a day.

"I love a good oatmeal molasses bread; a whole wheat bread with walnuts, rosemary and finely chopped sweet onion sauteed in olive oil for a roasted vegetable sandwich; or an anadama bread with split pea soup.

"Bread is part of a meal. It requires time and effort, but I can't think of many things worthwhile that don't."

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Vitanet ®

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Date: June 13, 2005 09:53 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Celebrity Holiday Fare - eating plenty of vegetables is the trendiest trend...

Celebrity Holiday Fare by Claire Gottlieb Energy Times, October 11, 2003

Trendy celebrities and trendy food go together like holidays and sparkling trees. Within the celebrity-filled universe known as the media, eating plenty of vegetables is the trendiest trend. And, according to the latest nutrition research, it also may be the healthiest.

Even before Frankenstein's monster picked up his first movie contract or endorsement deal, he was a vegetarian (for reasons best known by Mary Wollstonecraft Shelley, his creator).

Meanwhile, well-known actor Woody Harrelson, a fan of raw, vegetarian foods, professes that his devotion to uncooked veggies only reached firm ground when he became convinced they could and would taste fantastic. The tastiness of the recipes we've included with our inspection of the rarefied world of celebrity food prove that the celebrity predilection for these dishes keeps taste buds happy.

For Love of Pie

When preparing your holiday fare this season, taking tips from the dietary habits and favored dishes of celebrities may perk up your lunches and dinners. Healthy dishes can be delicious!

As Woody Harrelson points out in his foreword to Living Cuisine (Avery/Penguin) by Renee Loux Underkoffler, he became a fan of raw vegetables when he was convinced that they could be made into delicious dishes.

"Though I wasn't raw at the time, I knew enough to know that raw food and its emphasis on enzymes being the life force of the food is the way to go for optimum health and energy. Still, you can talk theory all you want; if the taste isn't there, color me a cooked-food junkie."

Eating dishes cooked by Ms. Underkoffler left him and Gabriel Cousens (a health book writer) speechless.

"We were struck dumb by our taste buds...the coup de grace was one of Renee's coconut cream pies, which, I confess, almost brought Gabriel and me to blows over the last piece." Other celebrities also find Ms. Underkoffler's food preparation skills to be superb. Alicia Silverstone raves, "I love Renee....Her food reflects that spirit, opening the senses to everything around you-it's incredibly rich and delicious and full of health and restorative energy. Her food is medicine." (But it doesn't taste like it!)

Birth of a Charitable Idea

Meanwhile other celebrities have taken their food act to a whole new level. Consider how Paul Newman's holiday habits led to his food adventures.

The story on Mr. Newman starts with salad dressing and Christmas. He and his friend, author A.E. Hotchner, originally created home made dressing and bestowed wine bottles of the stuff on family and friends for Christmas presents. Consequently, every holiday season Mr. Newman and his immediate family indulged in Christmas caroling and salad dressing giving. The demand for the dressing grew every successive holiday season until Mr. Newman and Mr. Hotchner decided to go commercial: Sell the dressing and make it available to shoppers throughout North America. The profits go to charity, and Mr. Newman bestowed about a million dollars to worthy causes in the first year.

In the early 80s, the Newman's Own brand started out with its Oil & Vinegar Dressing. Today they offer salad dressings, pasta sauces, salsas, popcorn, lemonade and other sauces. According to Mr. Newman, the two principles that rule the company are an insistence on top-quality products without artificial ingredients or preservatives and the donation of all after-tax profits from the sale of the products to educational and charitable organizations, both in the United States and foreign countries where the products are sold. Over $125 million worth have been donated since 1982.

In 1986, Mr. Newman founded The Hole In The Wall Gang Camp, along with Ursula Gwynne and A.E. Hotchner, with funds from Newman's Own and other donations. The camp, located in Connecticut, is for children with serious disease. (Newman recipes are available at the website: www.newmansown.com.)

Whether the latest celebrity trend wends its way to raw food or cooked creations, you can safely count on the fact that celebrity heads will rest easy tonight (and yours can, too!) knowing that they've eaten food that's both in fashion and healthy. Leo Tolstoy, the celebrated Russian novelist, once pointed out, "Vegetarianism serves as a criterion by which we know that the pursuit of moral perfection on the part of man is genuine and sincere."

When you try it for yourself, you'll find that serving mostly vegetarian meals may also offer evidence of a sincere devotion to better health and happier holidays.

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Vitanet ®

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Date: June 12, 2005 05:53 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Acupuncture nutrient Connection

Acupuncture nutrient Connection by Robert Gluck Energy Times, November 1, 1998

The theory behind the practice of acupuncture confounds western science. This therapy, originating in Asia, is based on the concept that currents of energy called meridians flow through your body. However, no one has ever been able to conclusively demonstrate the existence of these meridians.

Despite the evasiveness of these energy streams, Traditional Chinese Medicine (TCM) holds that alterations in these energy flows can disrupt health and cause pain. Consequently, an acupuncturist punctures your skin with specialized needles to redirect the body's vital energy.

Alleviating Illness

Despite the fact that western scientists have not been able to find satisfactory evidence of the existence of these energetic meridians, studies show that acupuncture works and is especially effective at relieving pain. This therapy has been used to alleviate a variety of conditions including chronic pain, nausea and even mental illness. In addition, some practitioners apply it to those trying to shake off the chains of drug addiction. (More recently, many practitioners now also successfully use acupuncture to relieve physical problems in animals.)

Of course, no matter what your perspective on this therapy, acupuncture's no panacea. While you might use acupuncture to relieve the discomforts of chemotherapy, you wouldn't use this technique as your primary weapon against a dangerous disease like cancer. Still, this reliable therapy occupies a welcome spot as an adjunct to many mainstream therapies. Consequently, many mainstream practitioners accept the validity of using acupuncture and many managed care companies reimburse this therapy. Some HMOs even keep a list of approved acupuncturists that they make available to enrollees.

Acupuncture East and West

The practice of acupuncture dates back at least 2200 years ago in Asia. Only during the last forty years has it become well-known and widely available in the United States. Today, 29 accredited acupuncture schools train practitioners in North America. In addition, traditional healers in Belize (south of Mexico) have been found to use a form of acupuncture derived from traditional Mayan medicine.

Is the use of acupuncture by Mayan shamans coincidence? Or further evidence that acupuncture meridians really exist? No one knows for sure, although some experts believe the Mayan use of this therapy supports the notion that the original ancestors of the Mayans migrated from Asia.

Needle Relief

Acupuncturists insert needles into the body to relieve pain or enhance bodily functions. TCM holds that acupuncture, and the manipulation of these tiny needles, moves and manipulates qi (pronounced chee), the body's energy force.

"Acupuncture is a method of balancing the body's energy," says Carol Alexander, an acupuncturist at the North Jersey Health and Pain Relief Center in Hackettstown, New Jersey. "Disease occurs because of an imbalance...Insertion of the acupuncture needles into meridians will bring about the balance of qi." Alexander has practiced acupuncture for 10 years and studied at the Tri-State School of Traditional Acupuncture in Stanford Connecticut.

Alexander says patients sometimes suffer a blockage of qi or display too much or too little qi. The manipulation and placement of the acupuncture needles vary according to the need for adjusting meridian energy flow.

Acupuncture can be used to prevent disease and, if disease is already rampant, it can be used to help the body correct the problem.

In conjunction with her use of acupuncture needles, Alexander rarely prescribes single herbs but uses combinations of whole herbs that are very specific for different diseases and disease patterns. "Certain herbs, such as ginseng, are very prized in Chinese medicine," Alexander notes.

"Astragalus is an herb used in China and around the world to tonify the qi and increase qi energy as well as stimulate the immune system."

Licorice Root

Alexander uses licorice root for assisting digestion and for helping women with menopausal discomforts. On the other hand, she recommends whole food concentrates like bee pollen granules for enhancing the immune system, peppermint for treating gastro-intestinal problems plus fiber supplements as well as the antioxidant/antihistamine quercetin, coenzyme Q10 and melatonin.

"In terms of classes of nutrients, I use a lot of whole food concentrates: the green concentrates like barley greens, wheat grass powder, spirulina and blue-green algae," Alexander says. "These are high in minerals, antioxidants, nutrients and fatty acids. I also use some soy products because the isoflavone concentrates are very much anti-cancer."

The Fine Points of Acupuncture

Acupuncture needles are very fine, as thin as hairs. They are available in a variety of diameters and lengths. When an acupuncturist inserts these needles, the sensation is that of mild pinpricks. (The needles enter the body at depths of only 1/8th inch to two inches.) In many cases people experience mild pleasure during needle manipulation.

"From a Western point of view it's important to explain that there is a distinct function of acupuncture treatment and that is to increase circulation," Alexander says. "We do stimulate nerves and we know that with the stimulation of nerves many neurochemicals and neurotransmitters are released. They move through the nerves and find receptor sights, some in the brain, some in other parts of the body."

By stimulating nerves, acupuncturists can calm inflammation and deaden pain. These effects are believed to be linked to the release of endorphins and dinorphins, powerful painkillers and anti-inflammatories that the body produces for itself. Most acupuncturists use this therapy as part of an overall, multi-faceted treatment plan.

Unique Energy

"Qi is what makes you different from a sack of chemicals," points out David Molony, an acupuncturist at the Lehigh Valley Acupuncture Center in Catasaqua, Pennsylvania who studied at the Nanjing Traditional Medicine Hospital in China and has lectured at Cornell University.

What You Need

"You can manipulate qi with acupuncture, herbs and diet. Because people's bodies work differently, there are different approaches. When you ask the question what nutrients and herbs are effective at enhancing acupuncture, it depends on what the person needs, according to an Oriental Medicine diagnosis."

An Oriental Medical examination, Molony says, begins with a long list of health questions designed to reveal factors that contribute to disease. A practitioner measures your pulse in several different places along your arm, inspects your tongue, may press on your stomach, sniff your general odor and closely examine your nails and skin for signs of problems.

"You take in everything you can," adds Molony, a board member of the Acupuncture Society of Pennsylvania and former board member of the American Association of Acupuncture and Oriental Medicine. "This gives you clues that you need in order to make your diagnosis."

Acupuncturists use nutrients and herbs that complement the treatment, as well as dietary and lifestyle counseling. Some acupuncturists don't specialize in herbal remedies, so these practitioners might go to a specialist like David Winston for advice. Winston, an herb expert skilled in Cherokee, Chinese and Western eclectic herbal medicine, works as an instructor, lecturer and consultant.

"In China, acupuncture is considered a complementary therapy; you generally don't go for treatment and get purely acupuncture," says Winston who is working on a book about saw palmetto. "Herbal medicine, diet and qi gong are important therapies in their own right and acupuncture is one of those therapies. Qi gong is a form of martial arts that focuses on unique breathing and visualization methods. Qi is not exactly energy, it's energy in movement; it's what makes the blood move."

Open Blockages

Acupuncture is used to open blockages that sometimes build up in what TCM practitioners characterize as excessive heat or cold. These hot and cold spots do not always literally refer to the temperature of the body but are meant to depict changes in the character of the body's vital energy.

Chinese acupuncturists don't necessarily treat diseases, but target clusters of physical discomforts. Winston says, "Herbal formulas change depending on the 'symptom pictures.' Somebody could have acute appendicitis but the symptom picture could vary. Usually Chinese acupuncturists use herbs like isatis (a very cold, drying herb that's a powerful anti-bacterial agent) and coptis (a powerful anti-bacterial herb)."

Americans often visit acupuncturists complaining of back pain or some type of musculoskeletal problem-a wrenched knee, a ligament that hasn't healed properly or perhaps a torn rotator cuff. "If the injury is hot to the touch, it's red, it's inflammatory-that's a condition where there's excessive heat and in that condition the acupuncturist would give herbs that are cooling and anti-inflammatory such as the root of large leaf gentian."

Pain that Moves

If someone suffers pain that moves, pain that is sometimes exacerbated by damp or humid conditions, acupuncturists often prescribe clematis root, a wild variety of the garden plant that is an anti-spasmodic, or acanthopanax, a relative of Siberian ginseng used for damp pain.

"If there's pain with excessive dampness," Winston says, "acupuncturists might use duhuo, a drying herb that opens the meridians."

Molony agrees with Winston that when it comes to choosing herbs to enhance acupuncture, accurate analysis of the root cause of the health problem is paramount to making the right decisions. For example, if a person is qi deficient and her tongue is thickly coated, she may not be processing her energy properly. Phlegm builds up, decreasing energy. "What you want to do is give them herbs that move phlegm, like citrus peel, and combine that with acupuncture points that move phlegm also," Molony says.

For stimulating metabolism, Molony uses lactoferin-processed colostrum from cows. He uses ginseng and atractylodes as qi tonics and he adds herbs like magnolia bark or atractylodes alba.

Helpful Antioxidants

He believes antioxidants are helpful too, as preventive medicines, including vitamins C and E. These valuable nutrients disarm the harm that reactive molecules can wreak within the body.

So how important are herbs and nutrition to enhance acupuncture's effectiveness? Acupuncturists seem to agree that healthy doses of antioxidants (such as vitamins C and E plus antioxidants from grapeseed extract) as well as specialized herbs, turn this therapy into a highly effective healing tool. Those wanting to benefit from this penetrating technique should stock up on nutrients. Then sit back, relax, kick off your shoes and let the acupuncturist do her stuff.

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Vitanet ®

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Date: June 12, 2005 02:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: In the Clear - Skin is always in danger of acne and inflammations

In the Clear by Dianne Drucker Energy Times, August 3, 2003

Your skin needs protection even as it offers itself as your body's first line of defense against the outside world. Skin is always in danger of acne and inflammations during its daily encounters with stray microorganisms, streams of ultraviolet light and a barrage of pollutants.

Tending to your skin, keeping a clear complexion while safeguarding your well-being, requires proper feeding, watering and tender, loving care.

Your skin not only has to protect you, it has to look good while doing it. Unfortunately, much can go wrong with skin. One of the most common skin irregularities is the acne that often arises when pores clog and inflammation creates unsightly blemishes.

While conventional medicine has long insisted that your chances of developing pimples are unrelated to what you feed your body and your skin, recent studies are calling that accepted wisdom into question.

Research in the Archives of Dermatology (12/02) argues that today's pimples are linked to what you ate yesterday. Skin scientists now suspect that the typical American diet, filled with refined foods, sugars and simple starches, causes the exaggerated release of insulin and related secretions that foment pimples and blemishes.

The evidence: When researchers spent two years combing through the rainforests of New Guinea and trekking to remote parts of Paraguay, they took a close look at indigenous people's faces and couldn't find a single pimple. The inhabitants of these isolated areas eat homegrown food and wild game. They've never eaten crackers or cookies from a box or slurped a milkshake through a straw. And they've never had to cope with embarrassing acne.

The researchers concluded that no refined foods meant no blemishes.

Refining the Pimple Process

According to this latest theory, pimples can start when your digestive tract quickly absorbs refined, starchy carbohydrates from white bread or potatoes or sugary soft drinks. These foods are ranked at or near the top of the so-called glycemic index. That means that these foodstuffs cause your blood sugar to climb rapidly, the process that the glycemic index measures.

That rise in blood sugar causes the release of insulin from your pancreas into your bloodstream. Insulin, a hormone-like substance, helps cells soak up the excess sugar circulating in your blood. However, along with insulin, another substance, is also released. These two chemicals boost the production of testosterone, the male hormone that, in turn, can cause the skin to overproduce sebum, an oily goo that plugs up pores and gives birth to acne. (Previous research has already established the causal relationship of testosterone to pimples.)

Lorain Cordain, PhD, a health professor at Colorado State University and lead researcher in this study, points out that more than 80% of the grains we eat are highly refined and cause significant blood sugar increases, a factor that makes skin break out. In addition, he says, teens are especially susceptible to pimples because they are growing rapidly and, as a result, tend to be insulin resistant. Insulin resistance means it takes more insulin to persuade cells to take sugar out of the blood. This condition consequently results in even larger amounts of insulin being released and more skin blemishes being created.

According to Dr. Cordain, eating low-glycemic foods like whole grains, vegetables, fish and lean meat should lower your risk of acne. These foods don't bump up blood sugar as much, to be released and, as a result, are kinder to your skin.

Helpful Microorganisms

Aside from improving your skin condition by improving the food you eat, taking supplements to help the bacteria in your lower digestive tract may also clear up your undesirable dermatological developments. Eczema, a discomforting and embarrassing skin inflammation, is now believed to depend on the interaction between intestinal bacteria and your immune system.

According to research in Finland (The Lancet 2001; 357:1076), eczema may appear on your skin when your immune system, influenced by the gut's bacteria, misbehaves, using unnecessary inflammation to defend against a non-existent infection that it mistakenly believes threatens the skin.

Atopic eczema, a variety of eczema that often runs in families, has long been known to be linked to allergies and immune overreactions.

In looking into the fact that more and more people have been suffering eczema, scientists came to the disturbing conclusion that this increase may be at least partly attributed to our obsession with cleanliness.

When we are young, our immune systems learn the proper ways to fight off germs by interacting with the bacteria and viruses they encounter. But during the past ten years, so many of us (and our parents) have kept our houses so neurotically spic-and-span, according to the latest theory, that our immune systems are failing to develop the proper responses. So, like a bored, inexperienced security guard who imagines a threat when there is none, our immune defenses are going slightly haywire, causing the defensive inflammation of eczema even in the absence of real bacteriological invasions. The possible solution: Probiotic supplements of harmless bacteria like Lactobacillus GG. This bacteria, similar to the friendly bacteria that live in our large intestines, seems to calm immunity so that it is less likely to panic and start an unnecessary inflammation.

These supplements are so safe, medical researchers are now giving them to pregnant women and newborn babies. In the research in Finland, giving these probiotics to mothers and newborns cut the rate of infant atopic eczema in half. (Similar, live bacteria are also found in yogurt, although yogurt should not be fed to newborns.)

The skin on these children is benefiting for long periods of time. "Our findings show that the preventive effect of Lactobacillus GG on atopic eczema in at-risk children extends to the age of 4 years," notes Marko Kalliomäki, MD, author of the study.

Tea Tree Help

Further natural skin help can be had from Australia in the form of tea tree oil (Melaleuca alternifolia). Long revered by the aborigines of this continent, tea tree oil was allegedly given its English name by British sea captain James Cook, who used the plant to make a tea that improved the flavor of beer.

But Australians have long used tea tree oil as an antiseptic. Its popularity increased during World War II, when, after it was used as a lubricant on heavy machinery, mechanics who got the oil on their hands noticed it fought skin infections. As pointed out in The Chopra Center Herbal Handbook (Three Rivers Press), "The essential oil of tea tree...contains a number of terpenes, of which terpinen-4-ol is believed to be responsible for its beneficial anti-infective activity." Terpenes are special, beneficial types of protein found in essential oils.

Tea tree is especially useful against skin outbreaks caused by fungus infections. Research in Australia shows that it can help quell athlete's foot (Austr Jrnl Derm 1992; 33:145) as effectively as some pharmaceutical preparations. Other research confirms that it can help quiet many different fungi that cause unsightly skin outbreaks (Skin Pharm 1996; 9:388). The Chopra Center Herbal Handbook recommends that "every household should keep some tea tree oil close at hand. It can be applied directly to skin irritations."

Calming Chamomile

Revered by the pharaohs' healers in Egypt during the ancient age of the pyramids, and depended upon for centuries by the Greeks for a variety of medicinal purposes, chamomile (Matricaria recutita) is still employed for a range of skin problems. This botanical helps ease abscesses, bruises or sunburn, and is included in many massage oils. (But never apply chamomile's undiluted essential oil to the skin.)

In addition, creams and sprays with chamomile are used to calm the nerves and nourish the skin. As an element in aromatherapy, chamomile, whose odor has been compared to apples, is well-known for soothing and rejuvenating the spirit. Explaining exactly how chamomile heals and calms has not been easy for scientists. Essential oils like chamomile contain so many different natural chemicals that exploring their holistic effect on the human body requires detailed analysis. As an aromatherapeutic agent, researchers believe chamomile and other essential oils may interact with the brain, activating glands that stimulate healing systems within the body. But that has yet to be proven.

What has been proven is that herbs like chamomile and tea tree, and natural treatments like probiotics, can make a big difference in keeping your skin healthy and clear. With their help, you can present your best face to the world.

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Vitanet ®

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Date: June 11, 2005 05:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Homeopathic Essentials

Homeopathic Essentials by Jane Lane Energy Times, February 1, 2000

The principles of homeopathy are elegantly basic and, to some, maddeningly elusive. This system of medical treatment employs The Law of Similars or "like cures like," and calls on natural plant, animal and mineral substances that induce the body to heal itself.

That homeopathy works is virtually incontrovertible. With its ancient roots and European practice spanning hundreds of years, homeopathy employs minute doses of diluted extracts to replicate symptoms of a malady, which then vanishes. But the very fact that it works puzzles many experts who have researched the phenomenon.

Understanding The Tradition

Homeopathy evolved from its earliest practice recorded by 10th-century BC Hindu sages to its codification by Hippocrates in 400 BC. " Through the like, disease is produced and through the application of the like, it is cured," he wrote, expressing the fundamental principle of homeopathy, according to Homeopathic Medicine at Home (Tarcher Perigee) by Maesimund B. Panos, MD, and Jane Heimlich. Samuel Christian Friedrich Hahnemann, the erudite and intellectually audacious German physician and chemist, seized upon the essentials of homeopathy in the early 1800s.

Through Hahnemann's work, homeopathy developed into an intricately systematized science, veering into the arcane for the contemporary individual seeking relief for everyday ailments.

Modern practitioners and manufacturers of homeopathic remedies benefit from Hahnemann's daring research (which included potentially lethal experiments on himself) and complex doctrines.

They've streamlined and modernized Hahnemann's concepts to provide more relevance to modern ills and sensibilities.

The Bold Experiments

Hahnemann denounced the medical practices of the 18th century, which involved cauterizing, bleeding, blistering and purging patients to expel the pernicious fluids or humors believed to cause disease.

He also reviled the kind of omnibus prescription drugs of the day, which loaded many substances into one compound. In 1790, Hahnemann conducted his groundbreaking experiment establishing the basis of homeopathy.

The customary treatment for malaria at the time was Cinchona officinalis or Peruvian bark-quinine. Medical wisdom attributed its efficacy to its bitterness and astringency. Hahnemann rejected this explanation, noting that other botanicals are far more bitter and astringent, yet are powerless against malaria.

To prove his theory, Hahnemann took some cinchona compound and promptly developed the symptoms of malaria. His deduction: Like cures like, or The Law of Similars. A substance that, in minute doses, induces certain symptoms in a healthy person cures a sick one.

The Set of Laws

A set of fairly complex laws developed from Hahnemann's initial Law of Similars.

The Law of Proving refers to the process of ascertaining the effectiveness of a homeopathic therapy by administering a substance to a healthy person to record in minute detail its effects. Practitioners also use the standard double-blind method using a placebo or unmedicated tablet against a homeopathic compound.

The first proving was performed in 1790 and the procedure endures today, using only humans, not laboratory animals, for greater accuracy. As homeopathic preparations are not toxic, proving has never produced lasting adverse reactions. Descriptions of provings are compiled into books called materia medicas, including Boericke's Materia Medica and Repertory and The Lectures of Homeopathic Materia by James Tyler Kent, used regularly in contemporary practice.

The books are highly indexed collections of symptoms and the remedies that cure them called repertories. The most extensively used repertory is Kent's Repertory of the Homeopathic Materia Medica.

In 1800, the third Law of Potentization was devised, regulating the processing of homeopathic remedies through successive dilutions and shaking.

This law represents perhaps the profoundest mystery of homeopathy and demands the boldest leap of faith: The higher the dilution, the more intense the potency of the medicine. Substances that are inert in their natural state act as medicine. And as they are so dilute, homeopathic remedies do not act directly on the tissues, accounting for their non-toxicity. Adding to the inherent safety of homeopathic therapies is the discipline's adherence to the single remedy. Centuries ago, homeopaths seemed to have been prescient about current drug interaction troubles.

(Historical information courtesy of Homeopathic Medicine at Home by Panos and Heimlich.)

How It Works: The Vital Force Homeopathy embraces a philosophy centered on the concept of "vital force," an intelligent, dynamic life force within each individual responsible for maintaining one's life and balance on all levels. The vital force creates a defense mechanism similar to the immune system, but incorporates protection against imbalances on the emotional and mental planes as well.

Homeopathy equates disease with imbalance. As the defense mechanism attempts to restore balance, symptoms appear: pain, swelling, rashes and fevers on the physical side; grief, jealousy, anxiety, anger, confusion and loss of memory on the emotional and mental end.

Homeopaths regards these symptoms as evidence of the vital force's curative exertions, not merely annoyances to be eliminated. Symptoms guide the homeopath in his or her attempts to harmoniously augment the efforts of the vital force.

Homeopathy Today

Homeopathic remedies are prepared according to the standards of the United States Homeopathic Pharmacopoeia and are recognized by the US Food and Drug Administration. " Homeopathy respects the complexity and uniqueness of each individual," observes pharmacist and naturopathic doctor James LaValle (and his co-authors) in Smart Medicine for Healthier Living. "To identify the correct homeopathic remedy, you must carefully observe your unique-even quirky-behaviors and responses." Indeed the emphasis on the "unique, even quirky" may lead to the perception of homeopathy as a sketchy pseudo-science. Homeopathy simply does not fit the drug model of allopathic medicine.

Its ability to help people, however, has been repeatedly evaluated through rigorous scientific research. A comprehensive review in the British Medical Journal (302, 1991: 316-323) of more than 100 clinical studies of homeopathy published during the last 30 years revealed that 77% of those studies produced positive results for the people involved. A host of additional studies provides clinical evidence:

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Vitanet ®

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Date: June 10, 2005 09:59 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nutrients for Longevity

Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling.

How Do We Age

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain.

On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution.

Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.)

Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725).

Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460)

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise:

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184).

In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging.

Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls.

In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs. Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs.

For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68).

As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit.

In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too.

And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=283)

Date: June 09, 2005 05:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Improove Memory ...

Mesmerizing Memory by Cal Orey Energy Times, January 1, 1999

In the 60s, the same rock 'n' rollers who belted out "One pill makes you larger and one pill makes you small," often espoused the belief that certain pills could expand the mind. While counter-culture pill purveyors were pilloried for their pill-popping claims, 90s nutritional research has uncovered a stash of supplements that may amplify mental improvement.

Like a blues singer bending a high note, researchers are now humming with dramatic assertions that certain nutritional supplements can sustain and enhance concentration and memory function. For instance, studies reveal possible benefits for cognitive powers from vitamin C, magnesium and Ginkgo biloba. A recent report in the Journal of the American Medical Association (JAMA 278:1327-1332) said that an extract of Ginkgo biloba "can stabilize and, in some cases, improve the cognitive function and social behavior of demented patients."

A researcher in the Proceedings of the National Academy of Sciences noted that a daily dose of vitamin E may "help protect the brain and its memories from the ravages of time." And the beat goes on: other evidence indicates that zinc, iron and boron may pump up short-term memory attention span and cut the time it takes to perform mental tasks.

Neuronutrients
Neuronutrients-mentally helpful vitamins, minerals, fatty acids, amino acids and trace elements-offer an exciting key to keeping mental functions from succumbing to the degenerations of aging and disease. According to Dharma Singh Khalsa, MD, author of Brain Longevity (Warner Books) and an energetic campaigner for mental fitness through nutrition and exercise, vitamin E "can not only prevent deterioration of the brain, but actually reverse an important element of deterioration." Dr. Khalsa describes vitamin E as one of the most potent antioxidants, a fighter of the electrically charged free radicals that attack and break down cell membranes and nerve endings.

Lester Packer, PhD, professor of molecular and cell biology at UC Berkeley, told a joint 1996 United Nations-World Health Organization conference on Aging that "there is a growing body of evidence indicating that the free radical theory of aging and aging-related disease is valid," and that dietary and supplemental antioxidants can help fight illness and mental deterioration.

Vitamin E and other memory aids are believed to protect brain chemicals called neurotransmitters, "the ferrymen of the brain's communication system," that influence concentration and memory. Experts say that sustaining the level of these nerve chemicals in the brain can potentially improve all mental processes.

Brain Well-Being
"Your brain is intricately bound up with your physical state of well-being and is, therefore, vulnerable to any kind of physical abuse, especially that of chemical or substance abuse," report Thomas H. Crook III, PhD, and Brenda Adderly, MHA, co-authors of The Memory Cure (Pocket Books).

Too much alcohol, for example, commonly causes progressive mental decline, according to Secrets of the Superyoung (Villard) by David Weeks and Jamie James. The authors also point out that "the memory tends to worsen noticeably after 15 years of alcohol drinking, and much sooner in people who go on massive binges."

"The effects of cigarette smoke are subtler because the poisonous effects of carbon monoxide in each puff are temporarily offset by the alerting effects of the nicotine," they add. Can't remember the name of that singer cavorting in a music video? Tests have shown that smokers are worse at connecting peoples' names to their faces than nonsmokers.

Cognition Ignition
A first step in beginning your brain-boosting regimen consists of intensified intellectual activity, insists Rebecca Rupp, writer of Committed to Memory: How We Remember and Why We Forget (Crown): n Keep working: The mental challenges and social interactions of a job prevents lapses in the brain's synapses.

n Learn something new: A second language, musical instrument, or unique puzzles and games keep neurons working like new.

n Turn off the TV: Read. Studies show that passively watching TV requires less concentration than eating cereal. Mental rejuvenation also requires physical activity. Exercise increases oxygen flow to the brain, which supports memory, concentration and cognition. One study has shown that exercise significantly brightened the moods of middle-aged and older women, regardless of whether they were pre- or post-menopausal, with or without hormone replacement therapy.

Supplemental Brain Help
As you provide for your physical and mental vitality through healthy exercise and diet, you can augment your regimens with other supplements that research has shown to boost brain power.

Antioxidants, including the previously mentioned vitamin E (You haven't forgotten vitamin E already, have you?), provide crucial help for vigorous cerebral function. The free radicals created by tobacco smoke, air pollution, ultraviolet light and certain carcinogenic chemicals deconstruct cell membranes and may foster microscopic brain cell havoc. Antioxidant enzymes convert free radicals to more neutral, benign substances and nutritional antioxidants can neutralize free radicals by linking up with them.

Vitamin C, a brainy antioxidant all star, performs so well that, according to Dr. Khalsa, its levels in the brain are almost 15 times higher than in other parts of the body. This nutrient, he asserts, aids mental and physical longevity. In a UCLA study, people who ingested at least 300 mg of vitamin C daily lived more than six years longer than those who ingested less.

Mental Fat
As a brain protector, selenium ranks high. Your brain consists of about 60% fat and selenium is a master at restricting detrimental fat oxidation. At the same time, zinc takes part in antioxidant processes that quell free radicals and strengthens neuronal cell membranes, protecting nerves from damage.

Added to this mix, magnesium also scavenges free-radicals, according to Dr. Khalsa. Plus, experts recommend grape seed extract (phytochemicals that protect a wide range of cellular structures) to safeguard nerve cells and mental capacity.

B Vitamins for the Mind
John W. Rowe, MD, president of Mount Sinai Hospital and School of Medicine in New York and author of Successful Aging (Pantheon) states that "there is a significant relationship between blood levels of folic acid and vitamins B12 and cognitive decline." In other words, these vitamins seem to be necessary to eliminate a protein called homocysteine, which has been implicated in the development of coronary heart disease and cognitive problems. (Support for Dr. Rowe's conclusion appeared in the American Journal for Clinical Nutrition 63-306.)

Iron Mind
Iron also may strengthen memory. Since iron is involved in distributing oxygen to brain cells (and every other cell in the body), when you lack this mineral you may find it hard to concentrate. In the early 1990s, Harold Sandstead, MD, professor of preventive medicine at the University of Texas, discovered that women whose diets lack zinc and iron experienced more difficulties on standard exams than women with an adequate dietary supply. In his study of women aged 18 to 40, Sandstead found that giving these women more zinc and iron raised their scores on memory tests and average of 20%.

Boron plays a crucial part in mental function. Scientists at the USDA's Human Nutrition Research Center have linked boron deficiencies to chronic lethargy and fatigue. In brain studies, they found that the electrical activity of the gray matter in the boron deficient indicated increased drowsiness and mental sluggishness.

Huperzine Boost
Borrowed from Chinese folk medicine, Huperzine A (HupA) recently has attracted attention from researchers who credit it with enhancing cognitive function and helping folks suffering from disease-related dementia. HupA is an extract of the club moss Huperzia serrata and has been used for centuries in China to treat fever, inflammation and, most recently, dementia. Dr. Alan Kozikowski, professor of chemistry in the neurology department at Georgetown University's Drug Discovery Program, a researcher who first synthesized HupA and studied it extensively, reported in the Journal of the American Medical Association (JAMA, 277 (10):776-March 1997), that HupA is safe, having been used to treat 100,000 people in China.

HupA basically protects the brain from free radical damage (due to low levels of antioxidant defenses) and maintains or enhances crucial neurotransmitter action. More specifically, HupA helps reduce the breakdown of acetylcholine, the vital neurotransmitter, and makes this substance more bioavailable. In addition, HupA helps make choline accessible to the brain for the synthesis of acetylcholine, according to a study in Neuropharmacology (30, 1991: 763-768).

Normally, the brain manufactures sufficient levels of the chemical phosphatidylserine, a lecithin-derivative that helps boost neurotransmitter release, but deficiencies of vitamin B12 and folic acid, or of essential fatty acids, may retard that production. Low levels of phosphatidylserine in the brain are related to impaired mental function and depression in the elderly. Scientists reporting in Aging (5, 1993; 123-33) describe "good results" using phosphatidylserine in the treatment of age-related cognitive ills.

Ginkgo Brain Power
Researchers also have demonstrated that Ginkgo biloba extract (GBE) increases brain function mostly by boosting acetylcholine receptors and the transmission of nerve impulses, with no significant adverse reactions. GBE is effective not only for folks with Alzheimer's; it also helps when mental function is impaired by vascular deficiencies or depression. Keep in mind that experts believe that GBE requires about 12 weeks of supplementation to reach optimal effectiveness.

Another ingredient in what seems like an alphabet-soup of brain nourishment is DHA (docosahexaenoic acid), an omega-3 fat essential for normal brain function. Researchers met recently at The New York Hospital-Cornell Medical Center's Nutrition Information Center to discuss "Keeping Your Brain in Shape: New Insights into DHA." Their findings revealed links between low levels of DHA and Alzheimer's, depression, memory loss, attention-deficit/hyperactivity disorder (ADHD) and certain behavioral traits including aggression and hostility.

Mostly Fat
Since so much of the brain is fat, material like DHA forms the building block of brain tissue and the primary structural fatty acid in its gray matter. Although it is critical for mental and visual well being, the average American's consumption of DHA has declined since we're eating less of DHA's dietary sources: animal organ meats and eggs.

Researchers from the National Institutes of Health point out, however, that fish is an excellent dietary source of DHA. In their studies, they discovered that depression rates in Japan and Taiwan, where fish ranks a top spot on the menu, are significantly lower than in North America and Europe.

DHA also is crucial to the neurological development of children, according to findings published in Pediatrics (vol. 101, no. 1, January 1998). Researchers suggest that DHA-rich breast milk should be the model for infant formulas that enhance babies' neurological development. Scientists also have correlated some behavioral problems in children-ADHD, for example-to DHA deficiencies.

If you are a vegetarian, or have other cause for concern about a potential lack of DHA in your diet, you can rely on dietary supplementation of DHA. Bruce J. Holub, PhD, of the University of Guelph in Canada provided vegetarians in his research project with DHA supplements over a 42-day period and substantially increased their DHA blood levels.

The bottom line to enhanced mental performance is to take a balanced approach, says Robert Snider, MD, who specializes in preventive medicine in Massena, New York. "Maintaining brain power includes exercise, stress reduction and good nutrition." The message to keep in mind: Don't lose your nutritional balance or you could lose a piece of your peace of mind.

Recommended Reading: & Brain Builders (Reward Books, 1995), by Richard Leviton.

Brain Longevity (Warner Books, 1997), by Dharma Singh Khalsa, MD.

Omega 3 Oils to Improve Mental Health, Fight Degenerative Diseases and Extend Life (Avery, 1996), by Donald Rudin, MD, and Clara Felix.

Successful Aging (Pantheon, 1998), by John W. Rowe, MD, and Robert L. Kahn, PhD.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=261)

Date: June 09, 2005 09:35 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids

Essential Fatty Acids and Phospholipids

Essential fatty acids & phospholipids are primary constituents of cell membranes, and as such they are vital to the makeup of the human body. Essential fatty acids are used to generate certain intra-cellular hormone-like substances, including prostaglandins and leukotrienes, which are responsible for regulating key bodily processes. Source Naturals essential fatty acid supplements are potent, effective and chemical-free.

LIPIDS, CELL MEMBRANES & EICOSANOIDS

Almost by definition, life is composed of cells, and cells are defined by membranes. One theory suggests that, around four billion years ago, self-replicating molecules, similar to the ribonucleic acid or RNA in our own cells, were synthesized from organic molecules. These self-replicating molecules adapted to changes in their environment to increase their potential for survival. Thus began the process of evolution that has led, over the eons, to us. One turning point was when these molecules developed membranes - envelopes which could help concentrate chemicals needed for the cell's survival. There existed in the "primordial soup" substances uniquely suited to this purpose: a class of organic compounds we call lipids . Lipids are more commonly called fats, and in this health and image-conscious age people often think of them as something to be avoided. However, the word fat refers to a variety of substances with a diverse range of chemical properties, which are essential for survival and well-being . The simplest lipids, fatty acids such as palmitic acid, consist of a hydrocarbon "tail" connected to a carboxyl group (COOH). The majority of lipids in food and in the human body occur in the form of triglycerides - a molecular configuration in which three fatty acid chains are attached to a 'backbone' of glycerol (an organic alcohol composed of a 3-carbon chain with an alcohol group attached to each carbon). The major roles of lipids can be described as energy and storage, structural, and metabolic.

Energy and Storage

Molecules can contain more or less chemical energy. In living systems most of the energy needed to drive chemical reactions is derived from oxidation. Oxygen, the ultimate electron acceptor, is a strong oxidant: it has a marked tendency to attract electrons, becoming reduced in the process. When a molecule undergoes a chemical reaction from a high-energy reduced state to a low-energy oxidized state, energy is released. This is what happens in a fire: the high-energy carbohydrates in wood, such as glucose, react with oxygen, releasing heat and the low-energy molecules of carbon dioxide and water. This is similar to what happens in metabolism.

Most of the carbon in a fatty acid chain is highly reduced, which makes fats more energy-rich than the other organic molecules that can be burned as food. This is what we mean when we say fats are high in calories - a measure of the amount of energy released when a substance is oxidized. Fats contain more than twice as many calories as carbohydrates. This makes fats an important storage fuel for most of the body.

Structure

Another important class of lipids in the human body consists of the phospholipids. Like triglycerides, phospholipids contain fatty acid chains- in this case two, one saturated and one unsaturated, attached to a glycerol backbone. Unlike triglycerides, in phospholipids the third carbon of the glycerol molecule is attached to a phosphate (a molecular group that contains phosphorus and oxygen), which is in turn attached to either an amino acid or, in the case of phosphatidyl choline, a molecule of the B-vitamin - like substance, choline.

Their unique molecular structure makes phospholipids amphipathic, which means 'likes both':

Fats, being hydrophobic, tend to separate out from water. When fat is mixed with phospholipids in the presence of water, the phospholipid molecules attach themselves to the molecules of fat and bring them into the water solution, enabling the fats to dissolve in water.

Phospholipids form a structure called a lipid bilayer, a two-ply sheet of phospholipid molecules in which the hydrophilic head groups face outward and are in contact with the water, and the hydrophobic tails face each other on the inside of the bilayer. This structure is one of the key constituents of the cell membranes that surround every living cell.

The lipid bilayer of cell membranes is a fluid in which membrane-embedded proteins "float." These proteins serve a wide variety of different functions. Some are enzymes, serving to carry out chemical reactions in the adjacent solution. Some are involved in signaling, in which a biochemical action in a cell is 'commanded' by means of a hormone or some such other signaling molecule. Still others are involved in transporting substances across the membrane, into or out of the cell.

The functions of membrane-embedded proteins are dependent on a very precise balance of phospholipids for their function. Phosphatidyl serine, for instance, has a negatively-charged head group that associates preferentially with a class of membrane-bound proteins called ATPases. ATPases regulate, among other things, the balance of sodium and potassium in intra- and extracellular fluids, a balance that is necessary for the integrity of our cells and also for the electrochemical impulses that make up our thoughts and feelings. Without phosphatidyl serine, these vitally important membrane-embedded proteins could not function.

Cholesterol is a waxy substance that is essential to the structure of cell membranes, which depend for their function on a delicate balance between fluidity and solidity. Cholesterol provides a semifluid matrix, as well as enhancing membrane fluidity. About 80% of the cholesterol the body uses is manufactured by the liver; the other 20% is consumed in food. Elevated blood cholesterol levels are associated with heart disease. Saturated fats are converted into cholesterol more readily than unsaturated fats, and polyunsaturated fats usually depress blood cholesterol concentration to some degree. Researchers have thus recommended that people lower their consumption of saturated fats and increase their consumption of polyunsaturated fats. A process called hydrogenation , in which hydrogen molecules are added, is used to harden these unsaturated fats to create solid spreads, such as margarine. This process causes formation of altered fats called trans fatty acids. Although the results are not conclusive, human and animal studies have pointed to possible deleterious effects from consumption of trans - fatty acids, which are estimated to account for 5.5% of all fats consumed by Americans. These studies include one in men and women that showed harmful effects of trans - fatty acids on blood cholesterol ratios.

Metabolic

When each link of a fatty acid chain contains an atom of hydrogen, as in palmitic acid, that fatty acid is said to be saturated . If two carbon links are double bonded to each other, each has one less hydrogen atom, and the fatty acid chain is said to be unsaturated. If a fatty acid contains one double bond, it is said to be monounsaturated, and if it has two or more double bonds it is said to be polyunsaturated . Certain polyunsaturated fatty acids cannot be manufactured by the body and must be obtained from the diet. These nutrients are called essential fatty acids and are necessary for the normal function of all tissues. The essential fatty acids fall into two categories:

In addition to being phospholipid precursors, essential fatty acids can be converted to a class of hormone like intracellular messengers called eicosanoids. The physiologic effects of eicosanoids are potent in minute quantities. Their effects are so powerful that they need to be produced near the site of their action and are quickly inactivated. The important eicosanoids include the thromboxanes, leukotrienes and prostaglandins (PGs ). Prostaglandin molecules consist of a five-carbon ring with two side chains. They can be distinguished from each other by numbers that refer to the number of double bonds in their molecular side chains: 1-series PGs have one double bond, 2-series have two double bonds, and so on. Prostaglandins mediate a variety of bodily processes, including inflammatory reactions, blood vessel contraction and dilation, and platelet aggregation. The different PGs have different effects on the body, and different essential fatty acids act as precursors for different PGs.

Important essential fatty acids in humans are the omega-6 fatty acids, which include linoleic acid (LA), gamma-linolenic acid (GLA), and arachidonic acid (AA). 1-series PGs are derived from GLA and tend to cause blood vessels to dilate and reduce the stickiness of platelets (cell fragments in the blood that help initiate blood clotting). 2-series PGs are derived from arachidonic acid and tend to increase platelet stickiness and cause blood vessels to constrict. Meat and dairy products are dietary sources of the PG2 precursor, arachidonic acid; American diets tend to be rich in these foods. The rate-limiting step for production of GLA in the human body is an enzyme called delta-6-desaturase (D6D). The action of this important enzyme can be blocked by a number of different lifestyle factors, including a diet high in saturated or trans- fatty acids and chronic alcohol consumption. A modest increase in consumption of GLA will significantly increase the ratio of GLA to AA in the tissues, which may have a beneficial effect on the homeostasis of the cardiovascular system. Supplementation with omega-3 fatty acids, such as flaxseed oil or fish oil, is beneficial for similar reasons. Omega-3 fatty acids are precursors for 3-series PGs, which reduce platelet stickiness. Series-3 PGs also tend to inhibit conversion of AA into its metabolites, the 2-series PGs.

The lipid composition of our diets has changed radically in the 20th century. Our intake of saturated fats has increased dramatically, and trans fatty acids, which did not exist before the advent of modern food processing technology, now form a major part of our diets. We eat less fish and green leafy vegetables, important sources of omega-3 fatty acids, than our ancestors did. Far from being an inert, homogeneous substance, fat is dynamic and varied - a subtle and interactive matrix for many of the biological processes taking place in our bodies, minute by minute.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=251)

Date: June 03, 2005 05:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mega H- Hydrogen (H-)The Fuel of Life

Our universe is composed of millions of compounds, all derived from just 106 atoms. Of these elements, hydrogen is the first and most fundamental.

Hydrogen is also the most abundant element, comprising 90% of all atoms in the cosmos. In our sun and stars, hydrogen nuclei fuse to produce helium, the second element. This generates the enormous energy that powers life on earth. And just as hydrogen fuels the sun, so, in the human body, it is the essential factor in the electrochemical process that produces ATP, the energy molecule. Virtually all the millions of biochemical processes that occur every second of our lives are powered by ATP. These facts are well established. But they are so basic that, until now, they have been overlooked in the world of nutritional science. It took the dedicated research of Dr. Patrick Flanagan to harness the power of active hydrogen for health and human development.

Introducing a revolutionary breakthrough in the field of nutritional science: MEGA H-™ Active Hydrogen (H-), the Fuel of Life.

The Creation of Mega H-

For 30 years Dr. Patrick Flanagan’s life work has been to discover the health and longevity secrets of the Hunza people of the Himalayas. It is believed a much greater percentage of people there live past the age of 100, with far less of the diseases that ravage the West. The locals claimed that their secret was the cloudy, mineral-rich water that rushes down from the Himalayan glaciers. In studying the properties of this Hunza water, Dr. Flanagan found that silica crystals dissolved in the water were able to hold negatively charged hydrogen ions (H-). These compounds are technically called silica hydrides. This makes Hunza water a power source, filled with the same active H- that powers the human body.

Typically hydrogen has one positively charged proton in the nucleus and one negatively charged electron orbiting the nucleus. The two opposite charges balance each other, resulting in no charge. Active hydrogen, on the other hand, contains two electrons orbiting the nucleus, creating a negative charge. It is this active hydrogen in its charged form that the body needs to carry out its crucial functions. Dr. Flanagan has recreated this silica hydride compound as MEGA H-™.

Cellular Energy: ATP, Hydrogen and Mega H-™

ATP, adenosine triphosphate, is composed of three phosphates. The breaking of the bond between the second and third phosphates releases the energy to power virtually all cellular processes. Amazingly, we all generate enough metabolic energy to produce our own body weight in ATP every day just to function! Every second, each of our approximately 50 trillion cells consumes and regenerates 10 million molecules of ATP.

This massive energy generation (ATP production) is the fundamental core function of every human cell. Without it, basic activities such as cellular repair, and protein, enzyme, hormone and neurotransmitter synthesis would not occur. DNA repair and cell reproduction would cease. Thoughts, feelings, communication, and our ability to experience the world through our senses and change it through our actions would stop. The negative implication of poor energy generation for our health and vitality levels is significant. Many factors such as aging, poor nutrition and pollution can impede this critical energy generation. Negatively charged electrons from hydrogen are the source of the energy needed to generate this staggering amount of ATP. This energy production takes place in the mitochondria of the cells at the final stage of the Krebs Cycle, called the electron transport chain. Typically, the hydrogen comes from the breakdown of carbohydrates from food, which yields hydrogen as well as carbon and oxygen. But MEGA H-™ is an alternative, electron- rich source of hydrogen to power energy generation. In fact, MEGA H-™ has been shown to double the production of ATP and NADH, according to in vitro studies. (NADH is the coenzyme form of vitamin B-3, niacin, that carries hydrogen to the production site of ATP.) If this alone was all that MEGA H-™ could accomplish, it would be the most significant nutritional compound yet discovered. But its properties go far beyond energy generation. It is the body’s most efficient and effective antioxidant. MEGA H-™ also increases cellular hydration and the uptake of nutrients into each cell by lowering the surface tension of water (making water “wetter”). And it can improve athletic performance by lowering lactic acid levels after strenuous workouts.

Aging and Antioxidant Defense

Energy Decline: As we age, there is a decrease in our bodies’ ability to generate cellular energy—and oxidative damage may be a primary factor. Many scientists now accept the theory of aging first proposed by noted scientist Denham Harman, M.D., Ph.D., who argued that “aging changes are induced by free radical reactions, largely initiated by the mitochondria … the rate of damage to the mitochondria determines our life span.” Why is this? While oxygen is necessary for human life, the very act of breathing generates free radicals. Our mitochondria— tiny energy production plants—are the chief source of oxidants produced in our bodies. It is believed these oxidants damage the mitochondria in which they are produced, including the inner mitochondrial membrane, which is the site of ATP production. This would seriously impair the ability of mitochondria to meet cellular energy demands. The result: signs of normal aging such as impaired memory, hearing, vision and stamina.

DNA Damage: Oxidants also can damage the cell’s DNA. Hydroxyl radicals cause DNA strands to break; if breaks occur in both strands of DNA, the cell cannot repair the damage and will die. Normally, the body has mechanisms to correct or remove damaged cells. However, as we age and cellular energy production declines, the ability to correct these errors is significantly reduced. Left unrepaired, DNA errors may be passed on when cells divide. Over time, these errors can silently accumulate, leading to cellular changes that go unnoticed until body system imbalances become evident.

World’s Most Elemental Antioxidant

MEGA H-™ may be the world’s most powerful antioxidant. It is possible to measure the Oxidation Reduction Potential (ORP) of any compound. This rating, which measures the number of electrons present in relation to protons, ranges from (plus) +1,200 to (minus) -800 millivolts; the stronger an antioxidant is, the closer its ORP would be to -800. The more positive the ORP reading, the fewer the number of available electrons from active hydrogen. In chemistry, active hydrogen is defined as hydrogen with an extra electron, also known as the hydrogen anion, negative hydrogen or H-. The strongest natural antioxidants up until now, such as grape seed and green tea, have ORP’s of -100. But Mega H-™ has an ORP of -778 millivolts, as compared to distilled water, making it the most potent natural antioxidant available today. What’s more, MEGA H-™ is in a class by itself, compared to other antioxidants, due to its electrochemical structure. Free radi-cals—unstable molecules that are missing one or more electrons—damage cells by taking electrons from healthy molecules to balance themselves. When other antioxidants donate electrons to quench free radicals, they in turn become reactive free radicals and require electrons from other antioxidants to become stable. The new antioxidant also requires an electron to return to stability. This process continues, resulting in an inefficient and energy-consuming free radical cascade. But MEGA H-™’s negatively charged hydrogen molecule possesses two electrons instead of the typical one. This extra electron can be donated without generating the inefficient free radical cascade. Dr. Flanagan’s profound contribution was his discovery of a method for stabilizing and delivering negatively charged hydrogen (H-). Unlike taking other antioxidants, supplementing with MEGA H-™ provides a net gain of free radical-quenching electrons into the system.

Additional Health Benefits

MEGA H-™ has been the subject of additional positive research: Increases Cellular Hydration: Water is important to cells, interstitial fluids (surrounding joints, muscles and organs), and the matrix of blood. As the body’s primary fluid, water serves as a solvent for nutrients. Since water is used to carry nutrients into the cell, it is theorized that increased cellular hydration also increases the bioavailability of nutrients. Water also eliminates toxins and waste products from the body. From energy production to joint lubrication, all our systems depend on water. It has been theorized that aging results in cell dehydration. A study done by Gary Osborn and H. Salinas, M.D. of the Texas Institute of Functional Medicines suggests that silica hydride supplements like MEGA H-™ increase intracellular, extracellular and total body water levels. It is theorized they work by decreasing water’s surface tension, which allows water and nutrients to more easily enter cells and become available for use by the body. Assists In Exercise Recovery: During strenuous exercise, the oxygen supply to muscle cells is insufficient to meet energy demands. Muscle cells then turn to anaerobic respiration to continue to generate energy. This creates lactic acid, which diffuses into the blood, causing muscle fatigue, soreness and loss of endurance. A placebo-controlled study on six healthy males showed that blood lactate levels significantly decreased after exercise when silica hydride supplements were taken for one week before an exercise trial.

The Scientist Behind Mega H-™

This revolutionary approach to nutrition and health is the brain child of Dr. Patrick Flanagan. Dr. Flanagan was a child prodigy with an intense interest in electronics, biochemistry and physics. At the age of 12, he invented a guided missile and atom bomb detector. This technology was subsequently adopted for use by the U.S. government. At 14 he developed the Neurophone®. This device transmits acoustic information to the brain by means of radio waves into the skin, bypassing the eighth cranial nerve, and may allow some deaf people to hear. By the age of 18, he was named one of the Top Ten most promising young scientists in America by Life Magazine. Dr. Flanagan’s work with MEGA H-™ has its roots in his collaboration with Dr. Henri Coanda, a respected scientist who died in 1972. Dr. Coanda passed along his investigation into Hunza water to Dr. Flanagan. MEGA H- is the culmination of decades of research to bring the energizing and anti-aging benefits of active hydrogen (H-) to the world.

Mega H-™

Hydrogen (H-)The Fuel of Life

MEGA H-™ is the first supplement available in the natural foods industry to provide a large reservoir of freely available electrons to power the body’s diverse energy functions.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=169)

Date: June 02, 2005 12:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Heart Science - A Five-Tiered Approach to Heart Health ...

Heart Science 30 tabs

Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.

Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health

Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
1) generating energy,
2) decreasing harmful homocysteine levels,
3) fighting oxidized cholesterol,
4) maintaining the heart’s electrical rhythm, and
5) protecting artery and capillary linings.

Energy Generators for An Energetic Organ

Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.

There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.

CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10

Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.

Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21

HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.

Homocysteine Regulators

B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.

The Dangers of Oxidized LDL Cholesterol

While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.

When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.

The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.

Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.

Cholesterol Fighters

Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:

The Regulating Trio

Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.

Artery Lining Protectors

Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6

Capillary Strengtheners

Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.

Heart Smarts

The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.

Source Naturals HEART SCIENCE™

The Five Tiered Approach to Heart Health
Six tablets contain:
Vitamins and Minerals %USRDA
Pro-Vit A (Beta Carotene) 45,000 IU 900%
Vit B1 (Thiamine) 50 mg 3333%
Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
Vit B6 (Pyridoxine HCl) 25 mg 1250%
Coenzyme B6 (Pyridoxal-5-Phosphate)
25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
Vit B12 (Cyanocobalamin) 500 mcg 8333%
Folic Acid 800 mcg 200%
Vit C (Magnesium Ascorbate) 1500 mg 2500%
Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
Copper (Sebacate) 750 mcg 37.5%
Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
Potassium (Citrate) 99 mg *
Selenium (L-Selenomethionine) 200 mcg *
Silicon (From 400 mg of Horsetail Extract) 13mg *
* U.S. RDA not established.
Other Ingredients and Herbs
Coenzyme Q10 (Ubiquinone) 60 mg
L-Carnitine (L-Tartrate) 500 mg
Hawthorn Berry Extract 400 mg
Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
L-Proline 500 mg
L-Lysine (HCl) 500 mg
NAG™ (N-Acetyl Glucosamine) 500 mg
Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
Taurine (Magnesium Taurinate) 500 mg
Horsetail Extract (Yielding 31 mg of Silica) 400 mg
Inositol (Hexanicotinate) 50 mg

Reference:
1. Azuma, J., Sawamura, A., & Awata, N. (1992, Jan). “Usefulness of Taurine... and its Prospective Application.” Japanese Circulation Journal, 56(1), 95-9.
2. Blazso, G and Gabor, M. (1980). “Odema-inhibiting Effect of Procyanidin.” Acta Physiologica Academiae ScientiarumHungaricae, 56(2), 235-240.
3. Brattstrom, E. L, Hultberg, L. B., & Hardebo, E. J. (1985, Nov.). “Folic Acid Responsive Postmenopausal Homocysteinemia.” Metabolism, (34)11, 1073-1077.
4. Colette, C., et al., (1988). “Platelet Function in Type I Diabetes: Effects of Supplementation with Large Doses of Vitamin E.” American Journal of Clinical Nutrition, 47, 256-61.
5. England, M. R., et al. (1992, Nov. 4). “Magnesium Administration and Dysrhythmias...A Placebo-controlled, Double-blind, Randomized Trial.” Journal of the American Medical Association, 268(17), 2395-402.
6. Felton, G. E. (1980, Nov.). “Fibrinolytic and Antithrombotic Action of Bromelain...” Medical Hypotheses (11)6, 1123-33.
7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
18. Mortensen, S.A.et al. (1985). “Long-term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure.” Drugs Exp. Clin. Res., 11(8), 581-93.
19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
29. Tsuyusaki, T. et al. “Mechanocardiography of ischemic or hypertensive heart failure,” in Yamaura Y et al., Biomed. & Clin. Aspects of Coenzyme Q.2 Amsterdam, Elsevier/North Holland Biomedical Press, 1980, 273-88.
30. Verlangieri, A. J., & Stevens, J. W. (1979). “L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan S Incorporation...” Blood Vessels, 16(4), 177-185.
31. Werbach, M. R. (1987). Nutritional Influences on Illness: A Sourcebook of Clinical Research. New Canaan: Keats Publishing, Inc.
32. White, R.R., et al. (1988, Jul-Aug.). “Bioavailability of 125I Bromelain after Oral Administration to Rats.” Biopharmaceutics and Drug Disposition, 9(4), 397-403.
33. Whitney, E. N., Hamilton, Nunnelly, E. M. (1984). Understanding Nutrition, (3rd ed.). St. Paul: West Publishing Company.
34. Willard, Terry, Ph.D. (1992). Textbook of Advanced Herbology. Calgary, Alberta, Canada: Wild Rose College of Natural Healing.
35. Xiang, H., Heyliger, et al. (1988, Nov.). “Effect of Myo-inositol and T3 on Myocardial Lipids and Cardiac Function in Streptozocin-induced Diabetic Rats.” Diabetes, 37(11), 1542-8.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=155)

Date: May 27, 2005 09:40 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Calcium D-Glucarate and Tumors

Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Walaszek Z; Hanausek-Walaszek M; Minton J P; Webb T E Carcinogenesis (1986 Sep), 7(9), 1463-6. Journal code: 8008055. ISSN:0143-3334. United States. Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 3091283 AN 86298867 MEDLINE

Abstract

Using as a criterion the inhibition of serum beta-glucuronidase activity, dietary calcium D-glucarate is shown to serve as an efficient slow-release source in vivo of D-glucaro-1,4-lactone, the potent endogenous inhibitor of this enzyme. Using the 7,12-dimethylbenz[a]anthracene model of mammary tumor induction in rats it is shown for the first time that feeding the rats calcium D-glucarate-supplemented diet after treatment with the carcinogen, inhibits tumor development by over 70%. Supportive evidence is presented for the theory that calcium D-glucarate inhibits or delays the promotion phase of mammary carcinogenesis by lowering endogenous levels of estradiol(estrogen) and precursors of 17-ketosteroids. Therefore, dietary glucarate can be used to lower blood and tissue levels of beta-glucuronidase, and in turn of those carcinogens and promoting agents which are excreted, at least in part, as glucuronide conjugates.