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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin? Darrell Miller 12/7/23
High-Fiber Diet Found Beneficial To Cancer Patients Darrell Miller 4/22/19
Long-term consumption of yerba mate found to strengthen yourdigestive system Darrell Miller 1/4/19
Cascara Sagrada for Constipation Relief & Other Uses (+ SideEffects) VitaNet, LLC Staff 9/2/18
5 Signs You're Not Getting Enough Potassium and How To Overcome It Darrell Miller 2/21/18
Paleo Diet Plan, Best Paleo Foods + Paleo Diet Recipes Darrell Miller 12/6/17
Homemade Hair Treatment for Frizzy, Dry and Damaged Hair - How To Get Shiny Hair, Silky, Smooth Hair Darrell Miller 9/18/17
Doctors call for greater access to medical cannabis Darrell Miller 8/11/17
Prostate cancer breakthrough: Combination of three plant-based nutrients found to MELT AWAY prostate cancer cells Darrell Miller 7/3/17
Sugar and Your Brain Darrell Miller 5/25/17
Easy Healthy Recipes || How to Make Avocado Smoothie Darrell Miller 3/28/17
Resveratrol Is Good For Diabetic People Darrell Miller 3/11/17
Estrogen Dominance In Men Darrell Miller 3/1/17
Fiber-rich diet could cut colorectal cancer risk, study finds Darrell Miller 2/2/17
A New Marijuana To Relieve Pain Without The High Darrell Miller 1/19/17
The USA Comes in Last Again on Health Darrell Miller 11/27/16
World Osteoporosis Day: Smoking, high alcohol consumption increasing incidence of Osteoporosis Darrell Miller 11/23/16
health benefits of dhea and how it declines as we age Darrell Miller 11/8/16
US needs to stop sugar-coating research on nutrition Darrell Miller 11/4/16
What is the Krebs cycle and why is it important? Darrell Miller 8/16/15
How Huperzine Helps With Memory Darrell Miller 7/30/15
What Are The Benefits Of Carob Powder? Darrell Miller 9/20/14
Vitamin A -- Where It Comes from and What It Does. Darrell Miller 3/22/14
Is Beta Carotene The Safe Vitamin A? Darrell Miller 3/21/14
What is Xylitol? Darrell Miller 2/9/14
Erythritol - The Healthy Sugar Darrell Miller 2/7/14
CLA in Weight Loss Darrell Miller 1/21/14
How L-Glutamine Increases Memory And Cognitive Functions! Darrell Miller 1/20/14
Impacts of pantethine Darrell Miller 1/9/14
Deer Antler Benefit for Vitality and Improved Health Darrell Miller 2/6/12
What Makes a Good Probiotic Supplement? Darrell Miller 8/9/11
Probiotics are good for the intestinal tract Darrell Miller 10/19/10
Pumpkin Seed Oil Darrell Miller 9/15/09
L-Methionine Darrell Miller 5/2/09
Stop Constipation Darrell Miller 3/29/09
Very Berry - Antioxidants Darrell Miller 12/1/08
Guar Gum Fiber Darrell Miller 10/27/08
Glycine Darrell Miller 10/11/08
Chlorella Darrell Miller 10/3/08
Fiber Darrell Miller 9/12/08
FOS Darrell Miller 8/22/08
What Is Fiber? Darrell Miller 7/21/08
DIM For Estrogen Balance Darrell Miller 7/10/08
How Important Is It To Have Proper Digestion Darrell Miller 7/9/08
Garcinia Cambogia Darrell Miller 7/8/08
D-Ribose Darrell Miller 5/17/08
B Vitamin Supplements Darrell Miller 5/7/08
Don’t Live With Pain, Live Pain Free – Curamin Is The Answer Darrell Miller 4/24/08
Blue Green Algae a Super Food that is Foods Packed With Nutrients. Vegetarian Friendly Darrell Miller 4/11/08
Fat Controls our hunger centers in the brain! Darrell Miller 4/4/08
Artichoke Promotes Healthy Fat Digestion and Metabolism Darrell Miller 1/30/08
Join The Age Specific Probiotic Revolution For Better Health Darrell Miller 1/18/08
Eggs: An Excellent Source of Omega-3 Oils for Better Health Darrell Miller 12/18/07
Loose Weight By Cutting Dietary Fat Absorption Darrell Miller 12/8/07
Regulating Blood Pressure Naturally Darrell Miller 3/28/07
For Better Heart Health ... Darrell Miller 2/6/07
Med schools failing on nutrition teaching Darrell Miller 9/19/06
Remifemin symptomatic relief, scientifically supported* Darrell Miller 8/26/06
Perplexed about Protein? immunoglobulins to boost the immune system. Darrell Miller 4/29/06
Cholesterol Support FAQ's Darrell Miller 1/6/06
Vitamin C FAQ's Darrell Miller 12/27/05
GliSODin Anti-Aging and Antioxidant Protection Darrell Miller 12/19/05
CRN Steps Up Efforts Against Calif. High School Sports Supplement Bill Darrell Miller 9/26/05
Pain - Post Op and Relaxation Darrell Miller 7/13/05
Supports Healthy Blood Sugar Levels-Herbally Darrell Miller 7/5/05
Introduction Darrell Miller 6/22/05
The A Team Darrell Miller 6/14/05
Marilu Henner: Energy Personified! Darrell Miller 6/14/05
Your Healthy Harvest Darrell Miller 6/14/05
Fats for Life - the quality of the fat you eat is probably much more important than the... Darrell Miller 6/12/05
Energy Cycles - Stress and lack of energy don't just frazzle your nerves Darrell Miller 6/12/05
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Darrell Miller 6/9/05
Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids Darrell Miller 6/9/05
PREGNENOLONE - The Balancing Hormone Darrell Miller 6/4/05
Positive Thought - Balance Emotions and Mood... Darrell Miller 6/4/05
Heart Science - A Five-Tiered Approach to Heart Health ... Darrell Miller 6/2/05
Glycerylphosphorylcholine -- Supports Cognitive Function in AD ... Darrell Miller 5/24/05
KudZu, Treatment of alcohol dependence or alcohol abuse Darrell Miller 5/19/05
Androgens and 4-Diol and 4-Dione conversion to Testosterone... Darrell Miller 5/17/05
Important Information for Allergy Sufferers Darrell Miller 5/13/05




Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?
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Date: December 07, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body.

While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption.

GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age.

The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels.

In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body.

This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form.

But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them.

So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing!

Liver Health

When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ.

Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds.

During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances?

But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker!

The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning.

So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being!

Alcohol Intoxication

Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells.

To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes.

The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group.

The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver.

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels.

Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy.

In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management.

Beautiful Skin

By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions.

Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores.

Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects.

Skin Lightening

Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract.

The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women.

In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH.

Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin.

The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities.

In summary, the administration of Glutathione sublingual clinically studiedglutathione, whether oral, buccal, or topical, has shown promising results in skin lightening and the improvement of complexion. Studies have demonstrated that glutathione not only enhances skin brightness but also reduces hyperpigmentation, wrinkles, and minimizes pores. Moreover, its effects have been evident in as little as two weeks, with a sustained impact over longer periods. These benefits were observed across a range of different skin types and ethnicities. However, it is important to highlight that these findings are based on specific populations, and more research needs to be conducted to confirm the consistency of these effects across a broader spectrum of skin types and ethnicities. The studies have also confirmed that the usage of glutathione is well-tolerated with no serious adverse effects reported.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592)


High-Fiber Diet Found Beneficial To Cancer Patients
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Date: April 22, 2019 04:35 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: High-Fiber Diet Found Beneficial To Cancer Patients





A study recently unveiled by its researchers at the American Association for Cancer Research's news conference shows that melanoma patients undergoing PD-1 blockade immune therapy had improved chances of reducing or shrinking tumors by eating a diet high in fiber along with their treatment. 46 patients out of the study's 113 showed improved response to the immune therapy, due to improved beneficial microbes in their stomachs. The researchers are planning a full presentation at the Cancer Research Association's annual meeting on April 2nd.

Key Takeaways:

  • The American Association for Cancer Research recently held a news conference to unveil significant research data.
  • Study revelations went to the point that microbial environments in cancer patient's guts were changed when affected by high fiber diets.
  • The data emerged from data culled while following 113 melanoma patients receiving diets high in fruit and other types of fiber.

"Patients who had a high-fiber diet were found five times likely to reduce the growth or shrink tumors while taking an immune therapy."

Read more: https://www.medicaldaily.com/high-fiber-diet-found-beneficial-cancer-patients-430607

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6154)


Long-term consumption of yerba mate found to strengthen yourdigestive system
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Date: January 04, 2019 03:13 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Long-term consumption of yerba mate found to strengthen yourdigestive system





Over the past few years, a nutritional drink called Yerba mate has been rising in its popularity levels due to its known health benefits. A new health advantage that Yerba mate has been showing potential in, is its ability to help digestive issues over a long period of time. Yerba mate has been shown to help digestion through regulating insulin levels, and it even can possibly prevent obesity by helping our bodies burn fat at a higher rate.

Key Takeaways:

  • The body obtains the nutrients it needs through digestion which is the process of breaking down the food we eat through gut movement and released enzymes.
  • Sometimes, the things we eat do not get digested. This is not an evidence that your digestion is weak or faulty. They might be processed some other way.
  • When there are signs of bloating or constipation, then one has to take a careful look at his eating habits. They might need to be changed.

"Yerba mate, an herbal drink that’s been going through a surge in popularity over the last few years, is linked to various health benefits, including improved digestion."

Read more: https://www.naturalnews.com/2018-12-16-yerba-mate-strengthens-your-digestive-system.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5931)


Cascara Sagrada for Constipation Relief & Other Uses (+ SideEffects)
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Date: September 02, 2018 09:53 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Cascara Sagrada for Constipation Relief & Other Uses (+ SideEffects)





Cascara Sagrada for Constipation Relief & Other Uses (+ Side Effects)

For those people who are trying to find relief for constipation and things of that nature, there are many different options. Now, prune juice and the good old "push it out" have been working well for a really long period of time. However, as we all know, things have changed and not everyone is as tough as people were in the past. Therefore, there have been measures taken to see if this process can be more comfortable for people.

Key Takeaways:

  • Although used as an herbal laxative, it is not recommended for users to continue with Cascara Sagrada for more than a week.
  • The Cascara tree grows to around 32 feet and is at this time considered an endangered species.
  • Other than its strictly medicinal uses, Cascara is used in the processing of sunscreens and as a flavoring agent.

"So what does cascara do? Other than it’s long history of use as a laxative for constipation, some people believe it can be used as a treatment for liver problems, gallstones, and cancer — but the evidence to date for these uses is lacking."

Read more: https://draxe.com/cascara-sagrada/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5739)


5 Signs You're Not Getting Enough Potassium and How To Overcome It
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Date: February 21, 2018 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 5 Signs You're Not Getting Enough Potassium and How To Overcome It





When we are sick, we lose vitamins and minerals. We lose electrolytes through the flu and stomach viruses. When we lack potassium if we have water retention. Numberness or tingling can be caused to the loss of potassium. Potassium is responsible for the nervous system. The rhythm that a heart beats to can be changed when we do not have enough potassium in our system. Fruits are great for their levels of potassium, especially pomegranates and apricots.

https://www.youtube.com/watch?v=G0_7mkwycFs&rel=0

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5536)


Paleo Diet Plan, Best Paleo Foods + Paleo Diet Recipes
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Date: December 06, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Paleo Diet Plan, Best Paleo Foods + Paleo Diet Recipes





Our diets have changed a lot over the past few decades. Foods have come and gone and overall, we have gotten worse at eating. Processed foods are a lot more common now. Fruits and veggies are actually less common than processed foods. It is also impossible to go down the road a few miles and not spot a fast food chain that has sprung up in the area. The Paleo diet is a rejection of this fast food lifestyle.

Key Takeaways:

  • The Paleo diet- a diet of consuming only foods similar to the diets of our hunter-gatherer ancestors- has become popular for being associated with weight loss, reducing satiety, and other benefits.
  • However, the Paleo diet may also have downsides, as no definitive data has been found that it improves our health. Paleo diet also may restrict intake of healthy macronutrients.
  • Take care with starting a paleo plan. Not all paleo-friendly foods are healthy. Best advice is to talk to doctor if experiencing negative effects.

"The Paleo diet has been associated with many health benefits from better blood sugar levels to reduced inflammation. Considered one of the best diet plans for weight loss because it’s high in protein and fat and emphasizes nutrient-rich foods, it may also increase satiety and help correct nutrient deficiencies. Still, the diet has remained the subject of much controversy in recent years."

Read more: https://draxe.com/paleo-diet-plan/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5427)


Homemade Hair Treatment for Frizzy, Dry and Damaged Hair - How To Get Shiny Hair, Silky, Smooth Hair
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Date: September 18, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Homemade Hair Treatment for Frizzy, Dry and Damaged Hair - How To Get Shiny Hair, Silky, Smooth Hair





This video discusses the struggles of frizzy hair, what some of the main causes of frizzy hair are, and how to combat it on a daily basis using things from your kitchen to make a mask, etc. The video details the recipe for a hair mask containing honey and corn starch and conditioner. This concoction is applied to dry hair and the scalp and then all hair is contained in a shower cap. The video does specify for users not to apply to scalp if they tend to have oily hair. This is in informational video for those whom may be looking to tame their frizzy hair.

https://www.youtube.com/watch?v=0VL1MYw1Jr0&rel=0

Key Takeaways:

  • There is a homemade hair treatment for frizzy and dry hair. That is a sign that hair could have been damaged in the past.
  • Shiny hair can be obtained by using a simple recipe found here. That will help hair regain its silky and smooth texture over time.
  • That hair treatment is a popular option for people who have changed their lives. Shiny hair is a popular choice and one that is worth trying personally.

"No matter how often you suffer from frizzy hair you can use a variety of common ingredients from your kitchen to treat the problem with simple natural remedies."

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5259)


Doctors call for greater access to medical cannabis
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Date: August 11, 2017 11:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Doctors call for greater access to medical cannabis





Anyone in Malta who is in possession of CBD oil is in violation of the Dangerous Drugs Ordiance. People used to be able to get it from online health food stores, but three months ago the law changed. Many patients suffering from a variety of symptoms have been able to find some relief with the use of CBD and THC oil. Now those same people are suffering. Doctors advocating for a change in this policy support strict product testing and continuing education for healthcare professionals.

Read more: Doctors call for greater access to medical cannabis

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5106)


Prostate cancer breakthrough: Combination of three plant-based nutrients found to MELT AWAY prostate cancer cells
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Date: July 03, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Prostate cancer breakthrough: Combination of three plant-based nutrients found to MELT AWAY prostate cancer cells





A study by the University of Texas, Austin, has found that there is potential for treatment of prostate cancer using compounds found in common foods. ursolic acid, commonly found in apple peel, curcumin, found in the spice tumeric, and resveratrol, found in red grapes. These three compounds were tested together as a new combination approach to creating treatments. Working together, these compounds caused shrinkage of tumor cells and changed the way the cancerous cells metabolized nutrients that allow them to grow out of control.

Key Takeaways:

  • In a recent study it has been determined that three plant based nutrients can help prostate cancer
  • The nutrients can be found in apple peels, red grapes and tumeric
  • The Experiment shows that the nutrients help kill cellsprostate cancer

"A fascinating new study published in Precision Oncology has found that a combination of three plant-based nutrients “melts away” prostate cancer cells."

Read more: http://www.naturalnews.com/2017-06-30-prostate-cancer-breakthrough-combination-of-three-plant-based-nutrients-found-to-melt-away-prostate-cancer-cells.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4919)


Sugar and Your Brain
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Date: May 25, 2017 07:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Sugar and Your Brain





Sugar is found in 75 to 80 percent of our sustenance sources, and once it's changed over to glucose, it's the essential fuel hotspot for the whole body, including the cerebrum. Be that as it may, as vital as sugar is to the cerebrum, expending excessively can harm the mind. A characteristic reward is something that makes joy in the mind, which guarantees that the conduct is rehashed. The USDA expresses that you ought to devour close to 40 grams, or 10 teaspoons, of sugar every day.

Read more: Sugar and Your Brain

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Easy Healthy Recipes || How to Make Avocado Smoothie
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Date: March 28, 2017 11:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Easy Healthy Recipes || How to Make Avocado Smoothie





Avocado used to be seen as a fattening food that should only be eaten rarely. That perception has changed as it becomes clear that avocado is rich in healthy fat, vitamin E and carotenoids. Avocado is also rich in antioxidant and anti-inflammatory properties. It should definitely be included in your diet and there are many ways to do this. Watch this video for a recipe for a delicious avocado smoothie. It's simple to make and its ingredients are inexpensive.

https://www.youtube.com/watch?v=0bjx_enRmRk&rel=0

Key Takeaways:

  • Avocados have the anti-cancer properties by increasing cancer cell death by increasing oxidative stress in those cells
  • Avocados also promote health cell growth by providing anti-oxidants and nutrients
  • Prior studies have demonstrated that Avocado can protect from breast cancer, prostate cancer, and Acute Myelogenous Leukemia

"You should learn how to make an avocado smoothie because it can be a great morning meal to eat."

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Resveratrol Is Good For Diabetic People
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Date: March 11, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Resveratrol Is Good For Diabetic People





Resveratrol is really good for diabetic people. It can be a part of treating diabetes. In one study, it was found that resveratrol helps with controlling blood sugar levels. There were other experiments done as well to see what the effects were. It was found in the end that the drugs used to treat diabetes can now be used to treat Alzheimer's disease.

Key Takeaways:

  • Scientists found out that giving resveratrol to obese mice changed the makeup of the bacteria in their intestines in just six weeks and improved their glucose tolerance.
  • The scientists collected fecal matter from healthy resveratrol fed mice and transplanted it into pre-diabetic obese mice. Within two weeks their blood sugar levels were almost back to normal.
  • Medications or drugs used to control levels of glucose and regulate diabetes can be used to halt the onset of dementia as the two diseases are very much alike

"The medications or drugs that are used to control levels of glucose and regulate diabetes can be used to halt the onset of dementia as the two diseases are very much alike."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.sciencetimes.com/articles/10128/20170310/resveratrol-is-good-for-diabetic-people.htm&ct=ga&cd=CAIyGmE1ZjVlMDc0YzcwMWFjZWI6Y29tOmVuOlVT&usg=AFQjCNFjwZPGUUXRBaFZ_JbT1XxRC0zf_Q

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Estrogen Dominance In Men
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Date: March 01, 2017 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Estrogen Dominance In Men





Estrogen dominance in men and women is dangerous, and is a term that describes a condition where a woman can have deficient, normal or excessive estrogen, but has little or no progesterone to balance its effects in the body. Even a woman with low estrogen levels can have estrogen dominance symptoms if she doesn't have enough progesterone.

Key Takeaways:

  • Estrogen Dominance is not just a female disorder, it affects men too and it's fairly common due to our current diet.
  • Estrogen Dominance is dangerous for men. It can cause significant health issues if not addressed.
  • The four leading causes of Estrogen Dominance in men are "ways" of life and can be changed if you or someone you know suffers.

"Estrogen dominance is often thought of as a female-only disorder, however men suffer with it as well."



Reference:

//www.worldhealth.net/news/estrogen-dominance-men-ruining-your-health-/

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Fiber-rich diet could cut colorectal cancer risk, study finds
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Date: February 02, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Fiber-rich diet could cut colorectal cancer risk, study finds





No one likes to talk about cancer, it is a very touchy subject for most people. However, Harvard has been conducting a study for the last 30 years and the study says if you have a rich whole-grain cereal and protein diet you have a lower risk of getting Colorectal cancer. Colorectal cancer is the second most deadly form and the third most common of the disease. Every little bit helps when it comes to our health, especially when trying to prevent such life changing diseases.

Key Takeaways:

  • Doctor Raaj Mehta and colleagues from Harvard Medical School (USA) suggest that a diet rich in fiber and whole grains could influence the risk of developing colorectal cancer linked to a strain of gut bacteria called Fusobacterium nucleatum.
  • Fusobacterium nucleatum is an inflammatory bacterium that is thought to play a role in colorectal cancer by blocking the immune response triggered to combat tumor cells in the colon.
  • However, the behavior of tumors not containing Fusobacterium nucleatum was unchanged and the risk of developing colorectal cancer not containing the bacterium was not reduced.

"Colorectal cancer is the second most deadly form of cancer and the third most common form of the disease."



Reference:

https://www.yahoo.com/news/fiber-rich-diet-could-cut-colorectal-cancer-risk-131654632.html?ref=gs

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A New Marijuana To Relieve Pain Without The High
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Date: January 19, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A New Marijuana To Relieve Pain Without The High





The pure medical value of marijuana is apparently being isolated without getting the user high, LatinosHealth reports. The two main molecules in marijuana are THC (which contains the "high"), and CBD, which does not get the user high, but can relieve pain. Efforts are being made to isolate the CBD side of marijuana for pure medical use.

Key Takeaways:

  • The medicinal value of the intoxicating plant Marijuana has often been contested because of its side effects but a recent study claims it can be successfully used as a pain reliever and that too without getting high!
  • According to the Washington Post marijuana consists of two main molecules, one is an intoxicating agent called tetrahydrocannabinol or THC a mind altering substance and the other cannabidiol or CBD which does not get the user high.
  • Another New York University neurologist Orrin Devinsky and his colleague Daniel Friedman observed that patients receiving CBD apart from their usual medicines had 39 percent lesser convulsive seizures than others.

"Earlier researchers were of the opinion that CBD had no use in the human body while THC was used to treat pain, nausea, loss of appetite and other problems but that notion has changed as CBD has been used in the treatment of diseases like epilepsy, anxiety, schizophrenia, heart disease and cancer."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.latinoshealth.com/articles/22451/20170106/new-marijuana-relieve-pain-without-high.htm&ct=ga&cd=CAIyGjViYjkzZDJlODZhNjI0ZWE6Y29tOmVuOlVT&usg=AFQjCNF3P1maud1n4GwSlTDPPTgnFqgDXQ

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The USA Comes in Last Again on Health
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Date: November 27, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The USA Comes in Last Again on Health





America may be the land of opportunity, but it is definitely not the land of health. When ranked against 10 other countries, the United States was found to be inferior to all the others. We spend much more on health care in the United States, and yet, we have far less to show for it. A majority of low income people in America skip going to the doctor simply due to the cost. On the other hand, other countries have far more access to equivalent healthcare. Obama Care was supposed to help, but it seems to have made it worse.

Key Takeaways:

  • Americans are still struggling with their health, and rank last against citizens of 10 other wealthy countries when it comes to emotional distress, struggling to pay for care and skipping doctor visits, a new report finds.
  • The latest report from the Commonwealth Fund, which routinely points to the shortcomings of the U.S. healthcare system, shows not much has changed in 15 years or longer.
  • Americans still pay far more for medical care than people in other rich Western nations but have little to show for all that spending.

""The U.S. spends more on health care than any other country, but what we get for these significant resources falls short in terms of access to care, affordability, and coordination," said Commonwealth Fund President Dr. David Blumenthal."



Reference:

//www.nbcnews.com/health/health-care/united-states-comes-last-again-health-compared-other-countries-n684851?cid=public-rss_20161116

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World Osteoporosis Day: Smoking, high alcohol consumption increasing incidence of Osteoporosis
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Date: November 23, 2016 04:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: World Osteoporosis Day: Smoking, high alcohol consumption increasing incidence of Osteoporosis





Osteoporosis is a disease that affects bone density and is especially prevalent in women over 50. Women younger than 50, and even as young as 30 are experiencing this disease at a higher rate; poor lifestyle choices such as smoking and consuming alcohol may be the cause. Learn how, an active lifestyle, calcium intake and sun exposure can decrease the risk of osteoporosis, especially before menopause is reached.

Key Takeaways:

  • At 38 years of age, Pratima (name changed) believed she was too young to suffer from low bone density. However, after when she suffered a fracture in her arm after a minor fall, tests revealed she had osteoporosis of the level usually prevalent in women over 60!
  • Doctors at Columbia Asia Hospitals, Gurgaon say the incidence of osteoporosis or osteopaenia in women under 50 has markedly increased over the past 20 years. Bone loss is a silent condition which generally occurs slowly over a long period.
  • Osteoporosis may be linked to multiple risk factors. Smoking is an important factor depleting bone health in women today. Firstly, the toxic components of smoke upset the hormonal balance in the body, particularly affecting estrogen production.

"Tobacco smoking has a series of negative repercussions on health. While increased risk of cancer and cardiovascular disease is the most talked about."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.indiainfoline.com/article/news-top-story/world-osteoporosis-day-smoking-high-alcohol-consumption-increasing-incidence-of-osteoporosis-116110100312_1.html&ct=ga&cd=CAIyGmU0N2NhMzY3ZTc4ODMzY2U6Y29tOmVuOlVT&usg=AFQjCNFCiSzwvyNyMux731JZIPQ1hhQztQ

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health benefits of dhea and how it declines as we age
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Date: November 08, 2016 07:51 PM
Author: Darrell Miller
Subject: health benefits of dhea and how it declines as we age

The importance of DHEA to human health cannot be overlooked. Found in the bloodstream, dhea is the furthermost plentiful hormone steroid. It is secreted in the brain, testes and ovaries and produced by the adrenal glands. Adrenal glands is the major producer of DHEA hormone. This hormone is changed to other hormones essential in the body such as estrogen and androgen.

Health benefits of DHEA

  • It enhances appearance of the skin. This is because it keeps the skin hydrated, intensifies epidermal thickness, boosts manufacture of sebum and controls facial skin coloring in old people.
  • Limits the level of cholesterol in the body
  • Facilitates proper functioning of the brain thus heightening cognitive abilities of individuals.
  • When dhea is taken orally for a couple of months, it assists in improving sexual performance in men by stimulating sexual desire, controlling erectile dysfunction and yielding sexual gratification.
  • Dhea is attributed to boosting moods by reducing levels of depression and anxiety.
  • Plays a role in formation of bones by improving bone mineral density.

How DHEA levels diminishes with age

As we age, dhea levels biologically diminish. According to research by experts, in our young years, plenty of dhea is secreted since it is vital for brain development and growth. This gradually continues until the age of 25 years after which the levels start to decline. The impact of the diminishing levels of dhea are mostly felt when we hit 40 years and above. This is manifested in terms of difficulties in remembering information, low levels of libido particularly in women, dry skin and increased anxiety.

DHEA is a hormone that is essential to human beings as it aids in counteracting the aging process, making us feel good and above all improving our overall health. Taking dhea supplements for those aged 40 years and above will help keep at bay problems associated with low levels of DHEA.

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US needs to stop sugar-coating research on nutrition
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Date: November 04, 2016 05:49 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: US needs to stop sugar-coating research on nutrition



Have you ever seen research on nutrition? Do you feel that they often sugar coat everything when it comes to the research? If you feel that way, you aren’t the only one. In the past after a report on sugar and its contributions to heart disease, school cafeterias changed the menus. Before that can happen again to prevent that from repeating, a few things have to change. To learn more about research on nutrition and how it affects you, read more here in the article.

Key Takeaways:

  • The tampering of this Harvard research paper impacted 50 years’ worth of research on heart disease and nutritional science.
  • This transition contributed significantly to the current obesity problem, which costs over $100 billion in annual estimated health care costs.
  • The tampering of this Harvard publication reveals the damaging effects from industries meddling with scientific research.

"By pressuring universities to be transparent with the sources of their financial backers, and by increasing public funding for university-led research, I am confident that people will be able to once again deem scientific publications trustworthy."



Reference:

https://www.google.com/url?rct=j&sa=t&url=https://www.bupipedream.com/news/73958/sugar/&ct=ga&cd=CAIyGjY3NzEzYzg1MjE0ZjUwYzU6Y29tOmVuOlVT&usg=AFQjCNGGCQTIpOSW7K-VSDhmcfn4xkiSDA


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What is the Krebs cycle and why is it important?
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Date: August 16, 2015 07:14 PM
Author: Darrell Miller
Subject: What is the Krebs cycle and why is it important?

The Krebs cycle is a series of chemical response that helps in the production of Adenosine triphosphate (ATP) and carbon dioxide, a compound that is rich in energy.  This cycle happens with the combination of two carbon coenzymes and carbon complexes and goes through a series of changes to produce the required energy that is needed for the smooth functioning of living organism.  This cycle occurs in all the cells that use oxygen for their respiration process.  Carbon dioxide has an important role since it fuels breathing and the ATP also plays a vital role as it provides cells with a required energy for synthesis of proteins from amino acid and the reproduction of deoxyribonucleic acid.  These are considered essential for energy supply and for the continuation of any kind of life including human.

The Krebs cycle is known as the second phase of the aerobic respiration.  Aerobic respiration is composed of three phases, Glycosis is the first phase, followed by the Krebs Cycle, and last is the Electron phase.  These three stages are a series of a cycle that all living cells must experience to produce the required energy for the smooth functioning of the mechanism of life.

Why Krebs cycle is important?

Poor digestion, fatigue and lack of proper nutrition are the common complaints among the people of all ages all over the world.  This complaint comes when the body does not get proper nutrition or is unable to digest food even if it's available.  It leads to a chronic problem and makes most of the people suffer. But what makes them suffer? This is the listless metabolism that ultimately leads to slow Krebs cycle function. When Krebs cycle does not function properly, after a period of time it causes the accretion of undigested food remains in the blood vessels and also creates some other health complications such as constipation, fatigue and smoggy brain.  In the long run, it can create some other health complication that is severe and sometimes life-threatening. So to avoid this situation people usually prefer to take the Krebs cycle supplement.  This supplement resolves all these issues and also makes you feel energetic.

Why your body is reliant on Krebs cycles?

Krebs cycles are important since it helps to generate energy from the food, particularly from the carbohydrate. And you can get carbohydrate from grains, cereals, fats and also from vegetable and animal sources. You can also get carbohydrates from the proteins.

By definition, carbohydrates are the combination of three important things, carbon, hydrogen and oxygen and these things can be changed to glucose inside your body. Initially your body uses the carbohydrate as the foundation of glucose and then through a series of processing, the body gets the required amount of carbohydrates from the diet. And here Krebs cycle plays an important role to generate energy from the carbohydrate.

The Krebs cycle is considered important for producing energy, it does not help you to run fast and to be active only, and it also enables your metabolic process to work efficiently.


 

 

References:

//www.wisegeek.org/what-is-the-krebs-cycle.htm

 

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How Huperzine Helps With Memory
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Date: July 30, 2015 04:00 PM
Author: Darrell Miller
Subject: How Huperzine Helps With Memory

Memory refers to the process by which information is encoded, stored and retrieved when required.  Encoding makes information from the outside world to be sensed in form of physical and chemical stimuli.  In the first stage, information has to be changed in order to be put into the encoding process.  Storage is the process by which the information is maintained over duration of time.  The third of final stage is the retrieval process where the information stored is returned back to the consciousness.

Brain

One of the major problems that many people undergo is memory loss.  This is a condition in which a person cannot recall information or events that they would be able to remember in normal circumstances.  One of the most effective ways to help improve memory is by taking Huperzine.  This is a drug that has proven to help boost memory and learning.

Here are some of the ways on how Huperzine help with memory:

1. Boost the level of acetylcholine

Acetylcholine is a very important transmitter in the brain responsible for carrying out several functions including those associated to memory and cognition. It is released into the space between two cells, where it then stimulates nerve impulses from one cell to the other. When acetylcholine fails to work effectively, several types of brain dysfunction occurs. A shortage of acetylcholine is known to be the common cause of memory loss, decreased intelligence and learning ability. Huperzine helps in reducing the breakdown of acetylcholine and boost the duration and strength of nerve impulse. It makes the neurotransmitter more available leading to better memory and improved overall brain functioning.

2. Protection against free radicals

Huperzine offers protection against free radicals that are known to be the major cause of modern diseases. It decreases the activity of heightened free radical activity in the brain. This goes a long way in reducing the risk of having memory loss. It has also proved to be effective in helping adolescents improve their learning abilities and memories.

References:

//www.smart-publications.com/articles/huperzine-a-the-proven-therapeutic-treatment-for-memory-loss

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What Are The Benefits Of Carob Powder?
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Date: September 20, 2014 02:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Benefits Of Carob Powder?

carob plantWhat is nourishment?

Nourishment is something that is inescapable for the supporting of life. Like air, water and asylum nourishment is likewise a fundamental necessity in our everyday life. In his occupied life, men have overlooked the criticalness of having solid nourishment. A man is approaching each part of his existence without any difficulty and has a state of mind that cares towards everything without exception. Engineering has progressed a great deal in the most recent decades, so do our dietary patterns. Bread has changed into burger; new chicken into KFC and god comprehends what else. There are wellbeing supplements, which help to keep up an adjusted eating methodology and stay solid.

What is Carob?

Have you ever become aware of carob? Then again, carob extricates. It is a nourishing supplement readied from carob plant and some different elements. It is a plant, which was first found in western Asia and the eastern piece of the Mediterranean area. Beetle bean gum is the name of the gum got from the carob seeds. They additionally find their application in natural pharmaceutical. The carob plants powdered units are dried and are then could be utilized as an element within natural solution.

Typically, carob is utilized as a thickener and is utilized in the production of sustenance, pharmaceuticals, beautifiers and a few pints. Because of its focal points carob has picked up much notoriety are late years. A percentage of the preferences of the carob that is the purpose behind its colossal prevalence are: they are low fat, low calorie and are a low perk option for chocolate. It is likewise utilized as the stimulant that we can discover in chocolates. Carob is acquired as carob powder and carob chips.

Some bad result about carob

There are a few myths about the carob, for example, carob contains cocaine and consequently it could be utilized as an option. The fact of the matter is the carob contains a few measures of the bromine not perk. The point of interest of carob is that it does not result in heart palpitations if expended in a little sum.

Benefits of carob

Dr. Subside D'adamo had formed carob Extract that has numerous profits. Carob concentrate could be utilized to keep glucose levels up. The carob concentrate is initially a mixture of 4 synergistic parts and it will help for keeping up solid intestinal vegetation and it will hinder dysbiotic bacterial over development.

Carob concentrate could be said as a low calorie, nutritious nourishment for everybody. It is assessed that the carob concentrate contains just 11 calorie for every teaspoon. Different elements contained in the carob concentrate are nectar and glycerin.

Here are 11 great profits of adding Carob to your eating methodology.

 1- Contains Gallic Acid, which is utilized as an antibacterial, antiviral, against hypersensitive disinfectant.

 2- Very high in Vitamin E

 3- High in Calcium and Phosphorus

 4- Caffeine substitute if utilized as an espresso substitute

 5- Lowers Cholesterol

 6- Non-Dairy substitute

 7- High in Protein

 8- Treats Diarrhea

 9- High in Potassium

 10- High in Calcium

 11- Aids the Liver

 Mending the Liver Using Carob

A considerable measure of the studies have been on the liver, and exactly how paramount they are to our bodies and great wellbeing. Our livers are in charge of so much that we completely must get to be more mindful of how to keep it solid. Our livers break down all our nourishments, scrubs the poisons in our bodies, forms the majority of our tangible data, and is our high temperature heater. It is the main organ in the body that can recover.

Our livers are greatly ill used in our public, and adding Carob to your eating methodology can assume a paramount part in serving to recuperate our livers. Having a solid liver is key to recuperating whatever remains of our bodies, I profoundly suggest any individual looking to mend themselves and have a healthier lifestyle, to first concentrate on mending their liver.

Now is the ideal time that we need to begin contemplating our nourishment propensities. In the event that you wish for a solid longer life, change your eating regimen. There are numerous nourishment things that are solid and wonderful in the meantime, so dear companion begins minding your well being, at last cash is not everything.

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Vitamin A -- Where It Comes from and What It Does.
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Date: March 22, 2014 08:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin A -- Where It Comes from and What It Does.

beta caroteneVitamin A

Vitamin A helps battle off contamination. It likewise serves to keep your skin smooth and supple. You can get a great deal of vitamin A from your sustenance - with liver meats being the best source. A few vegetables - carrots, broccoli leaves (the leaves, not the stems), sweet potatoes and kale, run a far off second, alongside spread.

Dietary vitamin A hails from two sorts of sustenance:

* Animal sustenance sources give "dynamic" manifestations of vitamin A - the form can use the vitamin promptly. They are called 'retinoid'. Retinoid are frequently utilized within skin creams and dermatological pharmaceuticals, as vitamin A is well known for its skin revival properties.

* Plants give carotenoids (to illustration beta-carotene). Carotenoids are changed over by the constitution into vitamin A. Beta-carotene is the most widely recognized of the carotenoids. A brilliantly colored intensifies; this is the thing that gives carrots and sweet potatoes their orange shade.

"Collaboration" is the point at which two or more substances join to make an impact more terrific than either could perform on its own. All supplements in the constitution have a synergistic impact, and vitamin A is no special case. Assuming that you as of recently have an iron inadequacy that brings about frailty - insufficient oxygen-transporting red platelets that abandons you ceaselessly tired a vitamin A insufficiency too will exacerbate it. Iron and vitamin A supplements taken together for frailty are more viable than either of these taken separately. When you don't have enough zinc in your eating methodology, the figure has a harder time proficiently utilizing vitamin A.

The main sign of a vitamin A inadequacy is debilitated vision especially 'night blindness the powerlessness to see well in faint light. Vitamin An is utilized to structure the shades required in the retina for vision, and without enough A, your eyes can't do their employment. Keep in mind when your mother used to let you know to consume carrots so you could see well? There's truth in that old home cure.

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Is Beta Carotene The Safe Vitamin A?
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Date: March 21, 2014 02:29 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Beta Carotene The Safe Vitamin A?

vitamin a squashWhat is beta carotene

Beta Carotene is a capable pwerful antioxidant that is useful for the heart and circulatory. In the constitution, it is changed into Vitamin A for the support of solid skin, great vision, and a strong immune system. Vitamin An is fundamental for ordinary structure of epithelial cells that ensures the form from ecological defilement.

Profits of Beta Carotene

Beta Carotene is accommodating with keeping the hardening/thickening of the corridor dividers (dissimilated sclerosis). It additionally helps lessen blood cholesterol.

Beta Carotene might likewise be accommodating in the medicine of AIDS, waterfalls, macular degeneration, and leukoplakia. It additionally may be advantageous in activity impelled asthma, growth, coronary illness, hypertension, Alzheimer's sadness, migraines, and rheumatoid joint pain.

Beta carotene has been said that it may ensure against malignancy and coronary illness. These profits are said to be because of its capacity to help the insusceptible framework and act an influential cell reinforcement inside the human form. Cell reinforcements kill free radicals, which are very receptive compound substances that can harm inner unit structure and encompassing material. This can prompt maturing and untimely ailment.

Beta Carotene is a compelling cell reinforcement that is valuable for the heart and circulatory. In the physique, it is changed into Vitamin A for the support of sound skin, great vision, and a solid invulnerable framework.

Vitamin An is key for ordinary structure of epithelial units that secures the form from ecological pollution.

It helps in the counteractive action of night visual deficiency and xerophthalmia, and in the field of dentistry, finish hypoplasia or lack of the tooth lacquer. It likewise anticipates different skin issue, improve resistance and ensures the figure from different contaminations.

Since carotenes are fat solvent, they ought to be consumed with fats to advertise more stupendous ingestion of carotene in the physique. Cooking the sustenance for a couple of minutes until the cell divider breaks to permit the shade to blend with the fluid is an alternate variable that incredibly helps the retention of this significant substance in the body.

Sources

  1. //ezinearticles.com/386397

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What is Xylitol?
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Date: February 09, 2014 08:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Xylitol?

What is Xylitol?

xylitolXylitol is a 5-carbon Sugar alcoholic recognized even more particularly like a polyalcohol (polyol) and it has already been getting used because the 60's. You can find this within nourishments with regard to unique nutritional reasons as well as a number of without having Sugar goodies, candy, mints as well as biting down hard gums.

Never such as additional designed sweeteners, for instance, sorbitol, mannitol xylitol assists an all natural flavor and it has absolutely no after-taste. This particular organic sweetener additionally statements in order to help fat loss since it offers forty % less calories from fat compared to Sugar. Due to the reduced glycemic report worth associated with simply 7, this particular Sugar alcoholic beverages has developed into well-liked choice along with diabetes or even people with hypoglycaemia. It's minimum effect on blood sugar levels as well as doesn't assist insulin in order to metabolize. Some of the greatest recognized wellsprings of the Sugar alternative tend to be fruits, mushrooms, as well as lettuce.

In spite of, actually these types of sustenances most abundant in raised levels include only a fragile quantity of the actual Sugar. For example, 1 cup associated with raspberries consists of simply not precisely 1 gram from it. Appropriately, this particular Sugar alternative is actually in a commercial sense ready with the hydrogenation associated with wooden Sugar (zylose) deduced in the xylan hemicellulose polymer bonded present in hardwoods, hammer toe husks, birch trees and shrubs, oats, nutshells, and so forth. The entire chemical substance process is actually vitality severe as well as big size, consequently causeing this to be Sugar alcoholic beverages 10 occasions more expensive compared to desk Sugar, sucrose.

Additionally, I have to stipulate which around it's producer statements which it's 100% organic Sugar, the way in which this particular sweetener may be handled as well as changed in order to draw out the actual Sugar deposits certainly merely does not seem because wholesome or even an amazing identical to something which normally occurs within meals developed in the floor, is not which correct? It is just difficult to think about this a proper Sugar whenever it's already been therefore extremely dealt with.

Is Xylitol Safe?

Indeed, the actual FDA offers mentioned which Xylitol is actually secure with regard to human being usage within never-ending amounts. The primary threat may be the concern associated with Xylitol as well as young puppies. Don't allow your dog consume Xylitol as it might result in a unexpected as well as possibly deadly decrease within dog sugar!

What exactly are Xylitol's Many benefits?

1. It is normally fairly sweet without any unusual aftertaste

2. Appears & preferences such as Sugar

3. 40% less calories from fat & 75% much less carbohydrates compared to Sugar

Xylitol's Dental & Dental care Advantages

Xylitol represses the power associated with germs to stick to tissue within the mouth area as well as can't be digested through germs, therefore it significantly shells from the procedure which produces dangerous, enamel-eating acids.

1. No cario-genic (doesn't trigger cavities)

2. Reduces cavities through 80%

3. Substantial long term reduction in cavities (88-93%)

4. Reduces dental care plaque development through producing plaque much less adhesive

An additional well-known wellness declare of the Sugar is actually it's capability to homicide germs and steer clear of teeth rot as well as dental illness. It's also believed to assist reduce plaque as well as impede current cavities through decreasing. Like the majority of Sugar alcohols, it may change the calm laxative effect from higher dimensions. Based on research brought within 1977, spending 1. four oz . from the Sugar alcoholic beverages for each day time may cause diarrhoea in several topics. It's producer announced which within doses associated with bigger than 15 gr, that is around 3 teaspoons, the actual sweetener isn't secure for everyone to make use of. Diagnostic tests exposed which 1. 65 gr from it might lead to passing away inside a 100gram rat. An average little bit of xylitol-gum consists of 0. 7 -- 1 gram associated with xylitol, and therefore about 50 % the quantity of the actual sweetener is needed to perform the rat.

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Erythritol - The Healthy Sugar
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Date: February 07, 2014 05:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Erythritol - The Healthy Sugar

What is erythritol

erythritolErythritol is a naturally occurring sugar found in tree grown foods, for instance melons and grapes. Simply because Monk Fresh fruit is almost two hundred occasions sweeter compared to Sugar, all of us very carefully blend this along with Erythritol to let you make use of Norbu like a tea spoon with regard to tea spoon replacement for Sugar.

Sugar is among the ingredients I've arrived at recognize is actually leading to problems during my digesting. One of the biggest useful problems We encounter is actually which Sugar is actually put into a substantial way of measuring industrially changed nutrition -- sustenance exactly where 1 may believe there can be absolutely no Sugar, for example within breads.

Erythritol

Erythritol is among the organic Sugar alcohols. This occurs normally inside a couple of items from the dirt nourishments. The idea whenever industrially ready it's made from sugar through fermentation having a candida called Moniliella pollinis.

Sugar alcohols

Sugar alcohols aren't because fairly sweet because desk Sugar (sucrose) as well as include less calories from fat compared to sucrose. Additionally they do not metabolize through dental germs, henceforth trigger absolutely no teeth rot. There are many Sugar alcohols as well as a number of them are used because sweeteners, for example xylitol as well as sorbitol, within Sugar free of charge nourishments.

Never such as the additional Sugar alcohols erythritol doesn't have laxative effects since it is actually soaked up to the blood stream within the little digestive system. Additionally it does not impact blood sugar levels because desk Sugar will since it is actually released as they say the same within the pee.

Sugar isn't at all the only real material in the current traditional western consuming strategy leading to problems during my assimilation, there are many various ingredients, a few organic plus some chemically changed. As well as I'm not really at all alone experiencing problems being an aftereffect associated with consuming sustenance showed in order to all of us on the market. Much more people encounter problems being an aftereffect of the consuming program.

Sugar, or even sucrose, is really a organic carb that occurs normally within items from the dirt. Desk Sugar is actually from Sugar stick or even Sugar beets that consists of considerable amounts associated with Sugar. These days Sugar is actually prepared within more than 120 countries in the world, and also the complete worldwide planning exceeds 120 zillion lots for each 12 months.

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CLA in Weight Loss
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Date: January 21, 2014 10:05 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CLA in Weight Loss

What is CLA

claCLA, or conjugated linoleic harsh corrosive, has been the subject of an assortment of exploration in the previous numerous years. Over 200 studies have indicated that it may assume an exceptionally vital part in weight reduction, as well as in serving to battle disease, diabetes, and atherosclerosis (solidifying of the corridors). It is not made in the human figure, and is discovered commonly in meat and dairy fats, or as an over-the-counter supplement. Artificially, it is a marginally changed type of the fundamental greasy harsh corrosive, linoleic harsh corrosive, and an omega-6 fattening harsh corrosive. The CLA discovered regularly in the sustenance sources is most astounding in dairy cattle and bovines that expend an eating methodology rich in grasses, and the individuals who are nibbling in pastures; instead of the aforementioned bolstered monitored food, for example, grain, feed or silage. To quote Larry Satter, an Agricultural Research Dairy Scientist, "Pasture-nibbled cows had 500% more CLA in their milk than those nourished silage." Since the fat is the particular bearer of the CLA, the substance of the fat in the milk is extremely paramount. The higher the fat substance, the more stupendous the CLA sum is in the milk. This is as opposed to what is proposed when drinking milk. Skim or 1% is constantly proposed over the entire or 2%, to maintain a strategic distance from the overabundance calories and fat, since normally drain was tanked for the calcium content (or the protein). This adds an entire new profit to drain and dairy items, clearing a path for science to control the CLA substance of milkfat, and may open the entryway the CLA-improved sustenances.

Study on CLA

Scientists accept CLA helps square fat cells that are in the figure from topping off with fat by meddling with a fat-archiving compound regarded as lipoprotein lipase, and additionally, by expanding the affectability of units to the hormone insulin. Creature studies have likewise demonstrated an expansion in lean bulk and fat lessening, or fat blazing; furnishing positive progressions to form sythesis, a decline in general muscle to fat ratio ratios. It is known as a "fat eliminator" on the grounds that it revs up muscle metabolism, in this way, helping increment lean tissue, bringing about the figure to need more calories to capacity (since fat units smolder next to zero calories), accordingly accelerating the fat smoldering procedure to make vigor.

Much stays to be looked into the underlying instruments by which CLA pushes its assorted physiological impacts. The profits are genuine, in spite of the fact that more research with people requirements to be carried out. You ought not feel that taking CLA alone would phenomenally make you shed pounds, in the event that you are not joining a brilliant, solid, overall adjusted eating methodology and activity program on top of it.

Reference:

  1. //en.wikipedia.org/wiki/Conjugated_linoleic_acid

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How L-Glutamine Increases Memory And Cognitive Functions!
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Date: January 20, 2014 09:26 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How L-Glutamine Increases Memory And Cognitive Functions!

 L-Glutamine

brain memoryAssuming that you are one of the numerous people that experience the ill effects of cerebrum fogginess, weakness and even laziness, you can discover the easing you require since L-Glutamine enhances memory and cognitive capacities. This amino acid is extremely pervasive in a few parts of the mind, the spinal string, and even organs of assimilation and detoxification. These methodologies all work synergistically with one another to handle optimal health conditions that abandon you feeling extraordinary constantly. When you have ever battled to recall certain occasions, data, or basic portions, you have to adjust the way your cerebrum appreciates data, which might be adequately finished when you utilize L-Glutamine to upgrade memory capacity. This compelling cell reinforcement does everything, and revitalizes your cells so you profit from improved vigor levels for your health and against maturing necessities.

How the medicinal utilization of L-Glutamine enhances your memory

Presently you can encounter all the rushes of having the ability to recall again when you use this characteristic elective health supplement for sum figure quality and persistence. This animated amino acid works through protein combination and compound transformations in distinctive parts of the form which invigorate sound responses to happen. Engaging your psyche from the cell level up, L-Glutamine enhances memory and evacuates collections of smelling salts and nitrogen in the blood which at last influences the working of your cerebrum. Smelling salts is available when this fixing is changed over into glutamic acid which obliges certain measures of alkali. When you standardize these levels, the mind fogginess vanishes as your units accept fitting measures of oxygen and supplements for sound working.

Health points of interest of utilizing L-Glutamine to improve memory capacity

Furthermore, there are other sound motivating forces to utilize this part also. The point when this valuable substance is changed over into its hostile to oxidizing structure, it improves the benefit of the focal apprehensive framework, beginning at the cerebrum. It can likewise secure your nerves from harm because of hormones, chemicals, and extreme electrical indicators. When you utilize L-Glutamine to improve memory capacity, you are likewise diminishing the dangers of experiencing tension, melancholy, and a large portion of its identified indications in view of its stimulant qualities. This elective health supplement impacts the pituitary organ to discharge certain chemicals, indicators, and hormones all around the figure to equalize out physiological capacities.

Reference:

  1. //natural-alternative-health-supplements.com


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Impacts of pantethine
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Date: January 09, 2014 04:53 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Impacts of pantethine

What is Pantethine

vitamin b5Pantethine (bis-pantethine or co-chemical pantethine) is a dimeric type of pantothenic harsh corrosive (vitamin B5). It is made out of two particles of pantothenic harsh corrosive connected by cysteamine crossing over aggregations. The monomer of this compound is regarded as pantetheine and is a halfway in the generation of Coenzyme A by the form. Pantethine is acknowledged the all the more naturally animated type of vitamin B5, yet it is less stable, disintegrating over the long haul in the event that it is not kept refrigerated most vitamins B5 supplements are subsequently as calcium pantothenate, a salt of pantothenic harsh corrosive.

Dietary supplementation

Pantethine is accessible as a dietary supplement due to proof of its health profits. In different clinical trials of patients with hoisted cholesterol and triglycerides, absolute and LDL cholesterol were diminished by 12%, triglycerides diminished by 18%, and HDL cholesterol was expanded by 9%. These clinical trials were directed with day by day admissions running from 600 to 1200 mg/day. Inside this measurement go there is no proof of a measurements impact relationship, i.e. changes in lipid focuses covered over the reach of measurements. Immediate measurements reaction proof is not accessible in light of the fact that no trial tried more than one measurement. A couple of trials tried 300 mg/day with additional unobtrusive yet factually noteworthy effects.

Further deliberately regulated trials of 600 and 900 mg/d dosages have indicated factually huge bringing down of LDL cholesterol in people with extraordinarily or reasonably raised levels of blood lipids.

Physiological impacts

Two instruments of activity are proposed for pantethine. In the in the first place, pantethine serves as the forerunner for amalgamation of coenzyme A. In the second, pantethine is changed over to two pantetheine particles which are thusly metabolized to structure two pantethenic harsh corrosive and two cysteamine atoms. Cysteamine is conjectured to tie to and therefore inactivate sulfur-holding amino acids in liver catalysts included in the generation of cholesterol and triglycerides.

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Deer Antler Benefit for Vitality and Improved Health
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Date: February 06, 2012 04:06 PM
Author: Darrell Miller (support@vitanet.net)
Subject: Deer Antler Benefit for Vitality and Improved Health

When men want to increase their strength and their vitality in doing daily activities, they can always consume deer antler extract, which is believed to be able to help the body system gain more power. Not many people may realize that using such extract can really improve their vitality and their strength. Some people may consider it as a hoax, but there're several proofs and evidences that show this particular extract can really improve the testosterone level in men.

Originally known as a part of traditional and ancient medical treatment, this deer antler extract can be consumed to improve the testosterone level as well as the overall performance of the body system. When men consume the extract, they're believed to be able to experience: - Development in body endurance, lean body ability, and muscle mass. - Quicker recovery period from any physical injury. - Better sexual functioning - this benefit can apply to men and women. - Higher and better energy level and vitality. - Improved and better immune system. - Aging delay, since the skin and the hair will have better cycle growth that make them look younger - Stronger nutritional support for the entire body system, especially the joints and the bones.

Deer antler extract isn't only helpful in those areas, but it also helps reducing stress level. Based on a medical observation done by Dr. Fenessy from New Zealand, this extract was quite beneficial when used in previous Russian study. The medical patients who had undergone gastrointestinal tumor surgeries were taking the extract prior to their operation. And they had shown quite amazing result; their stress level was decreasing. There was also another research that measured the mental ability of the students. They had been given the extract before taking math test. Based on the result, their mental ability was improving. Based on the study done in Russia and New Zealand, the Western medical societies are starting to do researches concerning the usage of the extract as vitamins so the consumer can really achieve the medical and optimal benefits.

So, what's the relation of deer antler extract and the testosterone? Medical experts believe that the antler can increase the production of the androsternedione. The androsternedione is a natural steroid that is actually produced by the body. This substance is produced in the gonads and adrenal glands, which then changed into testosterone inside the liver. So, when people consume the antler, automatically, they will produce more androsternedione. When more androsternedione is produced, naturally the number of testosterone will also increase. Testosterone itself is also responsible for the improvement of metabolism and body's recovery ability.

This typical extract is mostly available in powdery form, although it's possible that it's also available in liquid form. People can always boil it, mix it with warm water, mix it with other herbs, or dilute it with alcohol. They can: - Combine it with ginseng for improved energy - Mix it with 40% of alcohol for tonic supplement - Combine it with Drynaria or Dipsacus for kidney treatment - Mix it with Dang Gui for strengthening the blood It's advisable that they should make a medium sized boil and then store it. They only need to consume the deer antler combination per ounce a day until the storage container is empty.

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What Makes a Good Probiotic Supplement?
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Date: August 09, 2011 01:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Makes a Good Probiotic Supplement?

Kal - Acidophilus Probiotic-5 60ct 3bilProbiotics refer to a group of microorganisms that help maintain homeostasis in the digestive tract and even produce vitamins, minerals, and other nutrients. Nutrition experts have long recommended the consumptions of friendly bacteria as they curb the populations of harmful pathogens in the gut. More importantly, studies have shown that they contribute to the prevention of gastrointestinal disorders.

Scientists have identified a diverse variety of bacteria and yeasts that work as microbes. Bacteria that manufacture lactic acid are the most commonly used probiotics in the food and drug industries. They comprise a large number of Gram positive and acid tolerant bacteria that are generally recognized as safe. Most of the species are utilized in the production of yogurt in addition to nutritional supplements.

Multi-strain probiotic supplements are deemed better, though most products contain only one strain of bacteria. Nonetheless, they all work on the same principle. Apart from the fact that they produce lactic acid, almost all strains available in the market possess the enzymes responsible for the synthesis of lactase. Hence, probiotics give special benefits to individuals suffering from lactose intolerance.

Lactobacillus is the genus of bacteria best known as probiotics. They are the most extensively studied of all microorganisms identified to be beneficial for human beings. It is an established fact that they provide a steady supply of nutrients. Their fermentation activity in the gut enables them to synthesize vitamin K and other organic compounds that promote healthy metabolism and lower blood lipid levels.

Some strains prevent constipation, diarrhea, indigestion, and many other disorders of the digestive tract. For one, probiotics are capable of digesting complex carbohydrates that usually pass the small intestines largely unchanged. These compounds are beneficial for blood sugar. The by-products add bulk to stool, speed up the passage of fecal matter in the colon, and promote regular bowel movement.

There are strains that release natural antibiotics called bacteriocin. These compounds either directly kill pathogenic microbes present in the gut or suppress protein synthesis necessary for their survival. By so doing, probiotics curtail population growth of harmful bacteria that are often incriminated in the disease activity of ulcerations in the alimentary canal and complications of inflammatory illnesses.

Due to the fact that each strain provides unique benefits to health, it is best to choose a probiotic supplement that contains several strains of friendly bacteria. It is also important to read on the total bacterial count the product promises to deliver. Medical professionals caution the supplementation of probiotics with very high amounts of bacteria as they may disrupt the natural pH in the digestive tract.

Probiotic supplements that require refrigeration are usually not shelf-stable, and thus its quality is likely to get compromised during shipment. There are products that use sustained release technology and formulated to withstand the acidic environment of the stomach. Experts believe that releasing probiotics in the intestines helps as friendly bacteria take up residence in the gut.

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Probiotics are good for the intestinal tract
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Date: October 19, 2010 02:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Probiotics are good for the intestinal tract

Many people confuse prebiotics with probiotics, yet they are as different as night and day. Probiotics are live bacteria that are beneficial to your gastrointestinal system, and that are available in various foods such as yoghurts and sauerkraut. Prebiotics, on the other hand, are relatively non-digestible (to humans) foods that enable the probiotics to grow and carry out their intended function.

Basically, probiotics keep your friendly bacteria functional and healthy. The majority take the form of sugary carbohydrates known as oligosaccharides, available from foods such as legumes, fruits and cereal grains. They are not destroyed by digestion, and reach your gut practically unchanged. Although they have relatively little food value to us, they certainly do to bacteria that break them down into the nutrients needed for their growth and development.

Without taking prebiotics, these probiotics would be of little benefit to you because they would have nothing to live on. They don't eat the same foods as you, and the myth that they digest the same food that you eat is just that - a myth! ~facebook~

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Pumpkin Seed Oil
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Date: September 15, 2009 11:15 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pumpkin Seed Oil

The word pumpkin comes from the Greek word pepon, which means large melon. This word was adapted by the French to pompon. Then, the British changed to pumpion and the American colonists later changed that to the word that we use today. The origin of pumpkins is not definitely known. However, they are thought to have originated in North America. The oldest evidence of pumpkins dated back to between 7000 and 5500 B.C. in Mexico. The pumpkin is a squash-like fruit that ranges in sizes of less than one pound to over 1,000 pounds.

Because some squash have the same botanical classifications as pumpkins the names are often used interchangeably. Pumpkins generally have stems that are more rigid, pricklier, and squarer than squash stems. Squash stems on the other hand are more often softer, more rounded, and more flared when joined to the fruit. Generally, pumpkins weigh somewhere between nine to eighteen pounds, although the largest species is capable of reaching a weight of over seventy-five pounds. The shape of the pumpkin varies greatly, ranging from oblate through oblong. Even though pumpkins are generally orange or yellow, some are dark green, pale green, orange-yellow, white, red, and gray. Pumpkins have bright and colorful flowers that have an extremely short life span. Some may only open for as short a time as one day. The color of pumpkins comes from the orange pigments that are abundant in them.

The pumpkin is associated with autumn holidays such as Halloween and Thanksgiving in the United States. Generally, the seeds are thrown away as waste. However, pumpkin seeds and their oil possess great beneficial properties. There are especially for ridding the body of intestinal parasites.

Research has determined that various squash, including pumpkin, have great parasite-fighting capabilities. Although scientists are not exactly sure which compound in pumpkin seeds is responsible for expelling the worms, the seeds are known for their ability to do so quickly and safely. They are even safe for children. Pumpkin seeds work best when a laxative is taken an hour after they are used.

Pumpkin seeds are used to strengthen the prostate gland. They are also great for promoting male hormone function. They have long been used to treat an enlarged prostate. Myosin, which is found in pumpkin seeds, is known for its ability to be essential for muscular contractions.

One can apply the oil of the pumpkin seed to wounds, burns, and chapped skin. This helps to soothe and help heal injured skin. The seeds and oil of the pumpkin plant are used to provide anthelmintic, demulcent, diuretic, nutritive, parasiticide, and mild purgative properties. The primary nutrients found in this herb are amino acids, beta-carotene, magnesium, zinc, essential fatty acids, vitamin E, and carotenoids. Primarily, pumpkin is extremely beneficial in treating intestinal problems, parasites, and tapeworm.

Additionally, this herb is very helpful in dealing with burns, gastric disorders, nausea, prostate problems, roundworms, chapped skin, uterine problems, and wounds. In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen while on prescription medications. For more information on the many beneficial effects provided by pumpkin, please feel free to consult a representative from your local health food store with questions.

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L-Methionine
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Date: May 02, 2009 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Methionine

Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body.

Maintenance of Cell Membranes

It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine.

This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids.

Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics.

A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis.

Muscle Development

Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue.

Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows.

Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow.

Detoxification of the Liver

Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine.

Methionine and Autism

Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals.

Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below.

Miscellaneous Benefits

Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system.

It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract.

Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems.

So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most.

Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine.

Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement.

Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.

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Stop Constipation
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Date: March 29, 2009 10:08 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Stop Constipation

Constipation occurs when one has difficulty passing stools, or infrequently passes hard, dry stools. This is the result of food moving extremely slowly through the large intestine. From time to time, most people experience constipation. However, lifestyle changes and better eating habits can help to relieve the symptoms and prevent recurrences. Constipation usually results from insufficient amounts of fiber and fluids in the diet. Fiber can be found in plant foods like whole grains, fruits, and vegetables. Fiber that is water-soluble takes on a soft texture and is helpful in softening the stools. Insoluble fiber goes through the large intestine unchanged and is helpful in adding bulk to the stools to stimulate bowel contractions.

Other factors that can cause constipation include inadequate exercise, advanced age, muscle disorders, structural abnormalities, bowel diseases, neurogenic disorders, and a poor diet, especially a heavy consumption of junk food. Constipation can also be a side effect of iron supplements and some drugs, like painkillers and antidepressants. It is also common during pregnancy. High levels of calcium and low levels of thyroid hormone can also lead to constipation. Those with kidney failure are also prone to having problems with constipation. Constipation is often caused by dehydration in older individuals, with depression being a factor in people of any age. Some medications, like cough syrups, pain medications that contain codeine, antidepressants, iron supplements, blood pressure and heart medicines, calcium supplements, and some antihistamines can also cause constipation.

A small percentage of people with spinal injuries and other similar problems have constipation because the nerves that usually regulate bowel movement have been damaged or destroyed. A condition referred to as Hirshsprung’s disease makes the normal excretion of feces impossible because the nerves inside the bowel are missing. The nerve cells in the colon can also be damaged by long-term use of laxatives, which makes constipation inevitable. A thrombosed hemorrhoid, anal fissure, or a pocket of infection at the anus can create a spasm of pain that is strong enough to contract the muscles and prevent the evacuation of stools.

Constipation can cause a variety of other ailments such as appendicitis, bad breath, body odor, coated tongue, depression, diverticulitis, fatigue, gas, headaches, hemorrhoids, hernia, indigestion, insomnia, mal-absorption syndrome, obesity, and varicose veins. It may even be involved in the development of other serious diseases like bowel cancer. It is important to have regular bowel movements in order to remove toxins from the body. Toxins from bowel bacteria and undigested food particles play a part in the development of diabetes mellitus, meningitis, myasthenia gravis, thyroid disease, candidiasis, chronic gas and bloating, migraines, fatigue, and ulcerative colitis. People can have bowel movements as infrequently as three times a week and still not be constipated, but there are some health practitioners that believe that it is important to have a bowel movement every day.

The following nutrients are very helpful in dealing with and preventing constipation: garlic, vitamin C with bioflavonoids, apple pectin, chlorophyll liquid, essential fatty acids, a multi-enzyme complex, a multivitamin and mineral complex, vitamin B complex, vitamin D3, vitamin E. Additionally, the following herbs are also beneficial: alfalfa extract, fennel seed, aloe vera, ginger, milk thistle, triphala, cascara sagrada, goldenseal, rhubarb root, senna leaves, and yerba mate.

Adding a good fiber supplement as well as the above mentioned supplements can help one stop constipation and start normal bowel movements again. Natural fiber, vitamins, and herbs are available at your local or internet health food store. Look for name brands such as Source Naturals, Solaray, Kal, Planetary Formulas, and Natures Plus to ensure quality and safely of all your natural supplement needs.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins, herbs, and fibers are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

--
Buy Fiber at Vitanet ®, LLC

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Very Berry - Antioxidants
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Date: December 01, 2008 10:23 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Very Berry - Antioxidants

It has been suggested that eating berries may be a delicious and great way for a person to protect themselves against heart disease. Blueberries are full of antioxidants, called anthocyanins, which have been shown to keep the memory sharp as you age. Raspberries, on the other hand, contain ellagic acid, which is a compound containing anti-cancer properties. All berries are a great source of fiber for the body, a nutrient that is extremely important for a healthy digestive system.

More so, berries have recently been studied for their effects on heart health. A recent study published by the American Journal of Clinical Nutrition found that people who ate berries on a daily basis had higher levels of HDL cholesterol, which is healthy for the heart, lower blood pressure, and less blood platelet clumping, which is a factor that can help to protect people against dangerous blood clots.

A new study, which tested seventy-two people who had one or more risk factors for heart disease, tested for the effects of eating berries on markers that deal with cardiovascular health. This trial, which lasted eight weeks, had half of the people eating berry mixtures of bilberries, lingon berries, black currants, strawberries, and raspberry and chokeberry juices two times each day. A combination of different berries was used in order to ensure that a large amount of polyphenols were taken in. As a control, the other people were given sugar water, sweetened wheat or rice cereals, or marmalade.

Among those people who had the highest initial blood pressure, systolic blood pressure dropped 7.3 mm Hg in the berry group compared to only 0.2 mm Hg in the control group. Although total cholesterol levels were unchanged, those people who were a part of the berry group had a 5.2 percent increase in protective HDL cholesterol levels. Eating berries also stopped platelet function, which means that it takes longer for blood platelets to clump together and begin forming clots.

Berries are good for you because they contain many beneficial substances such as polyphenols, potassium, vitamin C, folic acid, and fiber. Polyphenols are also found in cocoa, tea, red wine, onions, and other fruits and have attracted a lot of attention recently because of their potential health benefits. Some recent reports have concluded that polyphenols may potentially help to protect against both heart disease and cancer. Although the way that polyphenols work to promote health is not completely understood, it is assumed that it is tied to their antioxidant properties and their ability to enhance the body’s immunity while repairing DNA damage that occurs from smoking and exposure to other toxins.

The findings of these studies are extremely significant because they may be partly responsible for explaining the role it holds in protecting the cardiovascular system. By eating fruits and vegetables a person increases the efficiency and health of their cardiovascular system significantly. Other types of studies have recently been warranted so that they may identify the compounds and mechanisms that are responsible for the effects that have been observed to this date. Berry supplements are also available at your local or internet health food store.

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Guar Gum Fiber
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Date: October 27, 2008 04:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Guar Gum Fiber

Guar gum is what is known as a soluble fiber, and it is well known that it promotes a healthy colon. You will not find soluble fiber in what you believe to be 'high fiber foods', yet it is a very important part of your diet, particularly if you have problems with your colon such as Irritable Bowel Syndrome (IBS) or even colon cancer.

Traditional high fiber foods, such as bran, leafy vegetables and cereals, contain insoluble fiber that mechanically act as an aid to digestion and the movement of your food through your gastrointestinal system. Soluble fiber, on the other hand, is found in what are more commonly regarded as starchy foods, although unlike starch, the chemical bonds that attach the various sugar molecules together cannot be broken by the acids and enzymes used by your gastric system to digest them.

They thus pass through the body undigested, in the same way as insoluble fibers, and so contribute to the mechanical system upon which the peristaltic pumping motion of the intestine depends. Because it is not digested, soluble fiber contains practically no calories since it does not contribute to the metabolism of your body. Fiber imparts many benefits in addition to enabling your intestine peristalsis to move your food through your digestive system.

For a start they don't contribute to your nutrition, either negatively or positively, but provide bulk to what you eat and provide help to your bowel movements by giving the intestinal muscles something to bite on. One of the benefits of such foods is their effect on your blood sugar and preventing the onset of diabetes. They can also help you to avoid obesity through providing virtually calorie-free bulk to your meals. Some fibers can bind chemically to toxins and certain fats, and can clean out your colon. So what's the benefit of soluble fiber over the insoluble type, and where does guar gum enter the equation?

Basically, soluble fiber is water soluble while insoluble fiber is not. Insoluble fiber is contained in cereals, beans and peas, fruits and in fact anything that doesn't dissolve in water, even when acted upon by that concentrated hydrochloric acid that is the basis of your digestive juices. Soluble fiber can help to prolonging the time that your stomach acids and enzymes spend in digesting your food. Soluble fiber is reported as conferring many health benefits, and guar gum and pectin are two of its major forms.

Guar gum is obtained from the guar bean, indigenous to India and Pakistan, but also grown in the USA, China Africa and Australia. The bean is edible to humans, and also used as cattle feed and fertilizer. TO obtain the gum, the seeds are dehusked and milled, and the gum is a whitish powder, not gummy as you might believe. However, when dissolved in water it gels when it comes into contact with calcium or borax.

It is effective as a laxative, due to the bulk it forms when dissolved in water, and can relieve not only constipation, but is also an effective treatment for IBS, Crohn's disease, colitis and other conditions of the lower digestive tract. Because it enables the colon to eject toxins and other undesirable waste products much more rapidly, guar gum is good for the health of your colon, and absorbs not only toxins but also undesirable bacteria.

Guar gum is what is known as thermogenic: it helps your body to burn fat by converting it to energy, with a resulting increase in your body heat. Not only that, but because it contains very little calorie content, it can bulk up a meal, help to make you feel satisfied and lower the glycemic index of your meal. It is used in many types of weight loss products and diets, although its uncontrolled use can be dangerous due to the potential blockage of your esophagus through insufficient fluid intake. For that single reason you are unable to purchase guar gum in non-prescriptive weight loss products.

Another of the benefits of soluble fiber, and guar gum in particular, is that it accelerates the absorption of calcium in the colon. Since calcium is normally absorbed in the small intestine, as opposed to the colon, this is good news for those seeking to lose weight. The reason for that is that the dairy products which traditionally contain most calcium tend to be high in calories, and guar gum enables you to get your RDA of calcium from a diet lower in these products by maximizing the calcium extraction and absorption right through the intestinal tract, and not only in the small intestine.

It has also been found to improve your tolerance to glucose. One of the problems that diabetics have is that sugars are absorbed mainly in the small intestine, whereas guar gum also enables it to be absorbed in the colon. Therefore, while the overall absorption level remains constant, there are no peaks and troughs since the absorption is constant through the entire intestinal tract rather than all the demand being in the small intestine. There is therefore less of a demand for insulin at certain times after a meal, so that the overall level of blood insulin can be reduced.

Guar gum is used as a delivery medium for certain drugs. Where it is desirable for a drug to be released into the colon as opposed to any other part of the gastrointestinal tract, this is the ideal substance. Guar gum can be degraded, if not digested, by anaerobic bacteria (bacteria that live in the absence of oxygen). Certain drugs can be attached to the guar gum molecule, and after consumption will pass unchanged through the stomach, duodenum and small intestine.

However, when it reaches the colon, the anaerobic bacteria that populate the large intestine degrade the gum, and release the drug molecules into the colon where they are needed. There are a number of delivery techniques in addition to using the gum itself, including using derivatives of guar gum, using a combination of the gum and other polymers and also multiparticulate delivery techniques.

Partially hydrolyzed guar gum also seems to increase the population of your bowel with friendly bacteria, or probiotics, such as lactobacilli and bifidobacteria. These can help to prevent or reduce the symptoms of many bowel conditions, and probiotic drinks taken with guar gum can be extremely beneficial to people suffering the symptoms of irritable bowel syndrome and other similar disorders of the lower intestinal tract.

So if you have a disorder of your lower intestine or colon, try a soluble fiber such as guar gum as a natural treatment, and where appropriate also take that with a probiotic. Most people find that their symptoms improve and in many cases they disappear altogether.



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Glycine
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Date: October 11, 2008 10:26 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glycine


The non-essential amino acid glycine is needed to generate muscle tissue and also for the conversion of blood glucose into energy. It is referred to as being ‘non-essential’ because the body can manufacture its own glycine, and is therefore not an essential component of your diet. Other uses to which glycine is put by the body includes the maintenance of a healthy nervous system, and is necessary for the proper functioning of the digestive system.

Amino acids play three essential roles in the human body:

1. They are the building blocks of proteins: proteins comprise about half of the dry weight of the majority of your body cells, and without them there would be no life. They are produced using monomers known as amino acids, and there are about 20 different amino acids used to make the vast variety of proteins that make up the human body. Proteins are needed to form enzymes, the catalysts that permit the majority of chemical reactions within our bodies, and also genes, the building blocks of DNA.

2. More relevant here, amino acids play an important role in the production of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) by phosphorylation with creatine phosphate. The more creatine phosphate available, the more ATP can be produced. Since ATP is the molecule responsible for the generation of energy, then the more ATP available the more energy is generated. Although creatine is available from many food sources, it is destroyed by cooking, and over half of what you use is made from the three amino acids, glycine, arginine and methionine. The energy produced in this way is very short-lived, and last only a few seconds - more on that later.

3. Glycine is heavily involved in the production of collagen, which is the substance that maintains the flexibility of your skin and other connective tissues while still maintaining their strength and firmness. Without glycine your skin would become slack due to the degrading effect of sunlight, free radicals and oxidation.

The non essential amino acid, glycine, is believed to offer other benefits to the human body, but it is the second of those above, the production of ATP, which interests us here. ATP is an extremely important nanomolecule, second in importance to the body only to DNA, and possibly also RNA since the two are linked. RNA makes copies of your DNA structure for use in cell division and growth.

When a cell expends energy for whatever reason, such as when I am typing this, or when your heart beats, or even when your liver synthesizes a protein, one of the phosphate groups is removed from the adenosine triphosphate molecule, and converts it to adenosine diphosphate (ADP). The ATP is then said to be 'spent', just as your energy is spent when you are tired and can exercise no more.

The ADP is then immediately reconverted to ATP in the mitochondria, a part of every cell in your body. A cell can contain hundreds, or even thousands, of mitochondria, the number depending upon that particular cell's need for energy. Hence, cells in your muscles, or in your liver where most of the body's chemistry takes place, contain thousands of mitochondria whereas those in your scalp contain a lot less. Once changed to ATP, a phosphate is again lost when energy is expended, and so the cycle continues.

Glucose is needed allow the ADP to be converted to ATP, hence the need for sugars, or the carbohydrates from which they are manufactured in your body. Each cell can contain up to a billion molecules of ATP, although the couch potatoes among you probably have a lot less! Your store of ATP molecules last about 2 to 5 seconds before being changed to ADP although more rapidly for athletes that expend a lot of energy. Then the energy stored in the form of glycogen in the liver kicks in for another 4 - 6 seconds.

Additionally, you cannot expend more energy that the (eventual) sugars that you take in your diet, which can be in the form of ordinary 'sugar' (sucrose), fruit (fructose), glucose, carbohydrates that are metabolized into sugars, or any other member of the sugar family (e.g. lactose, maltose, etc.).

Glycine is one of what are called glucogenic amino acids, which refers to their ability to provide glucose to the blood. Because it helps to maintain proper blood glucose levels, it is often prescribed for conditions that are caused by low glucose levels, such as hypoglycemia that shows symptoms of fatigue and tiredness, and also anemia and what is known as CFS (chronic fatigue syndrome).

The one activity of the human body, in fact that of any mammal, for which ATP is essential, is the heartbeat. Without that no mammal could survive, or any other creature that relies on a circulation system for life. The only reason you heart has to beat is to pump your blood around your body, and it is your blood that contains the oxygen and nutrients needed to sustain life. Your cardiovascular health relies on lots of ATP being available to power each and every heartbeat.

Analysis of the heart during the final stages of heart failure has revealed that there is a general decrease in the myocardial arginine: glycine amidinotraferase (AGAT) gene expression, which is indicative of the necessity of this enzyme for proper heart function. The enzyme is responsible for the first stage in the biosynthesis of creatine from glycine.

Creatine is well known to athletes, and while it is available naturally from some food sources, it can be destroyed during cooking, and at least 50% of the creatine needed by the body is produced in the liver, pancreas and kidneys. It is creatine phosphate that is broken down into creatine and phosphate, the latter of which is used by the mitochondria to regenerate ATP from ADP.

The study carried out on the reduced AGAT levels found in heart failure patients indicates the importance of glycine to heart health. Without a good supply of glycine, there will insufficient creatine produced biochemically to generate the phosphate needed to for the ATP to produce the energy required to keep the heart pumping with the required strength. The energy provided by the mitochondria is used locally by the cells in which it is produced, and within a few seconds of that production. As explained earlier, ATP stores are used up within 2 - 5 seconds, and glycogen stores within another 4 - 6 seconds.

That is why sprinters cannot keep running at maximum speed for more than around 10 seconds or so, because the immediate availability of glycine, and hence creatine, are insufficient to last longer than that. That is one reason why they have to finish those 100 meters as fast as possible, because otherwise they would run out of energy. Other than trying to win, of course!

However, when it comes to the heart, ATP stores are essential, and the cells in your heart require a constant supply of ATP from creatine, which itself depends upon your intake or biosynthesis of glycine. Since dietary sources are insufficient to meet all your needs, and destroyed by cooking, a glycine supplement is the only way to ensure a sufficient intake. You cannot undernourish your heart and remain healthy.

ATP biosynthesis is essential if that of glycine theoretically is not, but the fact that 50% of your glycine requirement has to be produced by your body and the other 50% is sensitive to heat during cooking, a supplement of glycine could be essential to many people.



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Chlorella
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Date: October 03, 2008 10:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Chlorella



A lot of us eat without really thinking about the food that we are putting into our bodies. This is extremely unfortunate because diet is crucial to human health. A good diet depends on choosing what to eat and how much to eat, because otherwise food can actually harm someone. People’s food choices in Japan have significantly changed in recent years, with the Japanese diet becoming more and more like the American and European diet, leading to an increase in various diseases that are associated with the Western diet increasing in Japan. This new Japanese diet is high in protein and fat and low in fiber, just the way the Western diet is.

These dietary changes have caused an increase in body fat, sticky blood, damaged blood vessel walls, and rise in dietary-related diseases like hypertension, diabetes, hyperlipemia, cancer, heart disease, and cerebrovascular disease. These diseases are abundant in Western countries, with the number one cause of death in the United States being heart disease. It has been found that the main cause of death in many advanced countries is related to diet.

Chlorella has the ability to prevent diseases that are caused by diet. Chlorella is a type of algae, the very origin of the food chain, and is a highly regarded health-food supplement for use in maintaining the human body. Introduced to the health-food marketplace about 40 years ago, chlorella was first established in Japan and today is produced by Japan, Korea, Taiwan, and Indonesia.

Not only is it used for health-food supplementation, but also in processed foods, food additives, medication additives, marine feeds, feed additives, and fertilizers. Chlorella is helpful in supplementing nutrients of high-quality, plant-based proteins, vitamins, minerals, chlorophyll, and antioxidants. It has been shown to help lower cholesterol, regulate the intestines, detoxify the body, lower blood pressure, and regulate the immune system, In short, chlorella helps the human body to maintain balance.

It is likely that Chlorella appeared on the Earth many thousands of years ago. It is a fresh-water, one-celled green algae that can be found widely in lakes and marshes throughout the world. This plant was discovered and named by M.W. Beyerinck of Holland in 1890. In size, chlorella is 2 to 10 microns, which is slightly smaller than a red blood cell. It is an ancestor of such vegetables as spinach and pumpkins. As compared to other plants, chlorella has a high concentration of chlorophyll, making its capability for photosynthesis many times higher than that of other plants. Because of its high-quality, plant-based protein, vitamins, minerals, dietary fiber, and antioxidants, chlorella is able to maintain human health and prevent and treat disease.

Diseases including hyperlipemia, hypertension, diabetes, arteriosclerosis, heart disease, stroke, and cancer are closely related to diet. Heredity, aging, and environmental factors including chemical substances and stress are also all liked to the above diseases. These diseases are on the rise in advanced countries, with a lot of them being the most prevalent causes of death in many countries. To prevent diet-related illnesses, the diet must be balanced and lowered immune function must be improved.

The body also needs to be protected from health-threatening chemical substances and stress. Scientists have found that Chlorella is effective for balancing the diet, improving lowered cell function and resistance, and detoxifying chemicals and alleviating stress. Many diet-related diseases can be prevented and treated by simply adding Chlorella to ones diet.



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Fiber
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Date: September 12, 2008 09:43 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fiber

The ileocecal valve, which is made up of sphincter muscles that close the ileum, prevents toxins and other materials that are released by the appendix from entering into the small intestine. Additionally, the ileocecal valve helps to keep digested material in the small intestine until all of the nutrients have been absorbed. When the food residue is ready for elimination, the small intestine mixes bile, mucus, and other excretions with the food residue and releases it systematically through the ileocecal valve into the large intestine. This process prevents an overload of material in the intestine for the body to eliminate.

When the toxic material of the colon is able to enter back into the intestine, where it becomes rapidly reabsorbed, ileocecal valve syndrome occurs, which can lead to infection and disease. Symptoms of ileocecal valve syndrome include constipation, diarrhea, fatigue, irregular bowel movements, lower right bowel tenderness, acne, immune weakness, migraines, and duodenal ulcers.

To avoid ileocecal valve syndrome one should eat a diet that is high in fiber and includes whole grains. These whole grains should be soaked and cooked in order to avoid irritating the valve. Foods that cause constipation such as diary products, meat, and bananas should be avoided. Raisins, figs, and stewed prunes should be eaten for breakfast. More fresh fruits and vegetables should be added to the diet. Softer raw vegetables such as leaf lettuce, spinach, avocados, sprouts, and tomatoes should be used first.

Additionally, one should reduce the amount of meat that they eat and take a fiber supplement in order to avoid constipation. Fasting on juices two or three days a week will help to speed the healing process of the digestive tracts. Grains that are thermos-cooked are healing on the digestive tract and rich in enzymes, vitamins, minerals, and protein. The slow cooking process protects the body from destruction of vital enzymes. Milet, buckwheat, and basmati brown rice can also be eaten for breakfast, as they are easy for the body to digest and extremely nourishing. Raw vegetables and fruits, steamed vegetables, yams, and avocados are all also extremely helpful in healing the digestive tract, so they are recommended.

Nutritional supplements that can assist with ileocecal valve syndrome include antioxidants, vitamin A, B-complex, vitamin C with bioflavonoids, calcium, magnesium, essential fatty acids, blue-green algae, acidophilus, and plant digestive enzymes. Also, aloe vera juice, cat’s claw, grape seed extract, pau d’arco, licorice, goldenseal, slippery elm, and comfrey are great herbal aids for helping for ileocecal valve syndrome.

Colon health is a lot more important than most people realize, as the digestive process is directly related to the health of the body, immune system function, and overall longevity. When any disease occurs, the colon should be the first thing looked to for treatment. By understanding what it means to have a healthy colon, adding fiber, nutritional supplements, herbal aids, and a change in diet, one can promote overall colon health. Eating habits should be changed slowly and unhealthy, nutrition robbing foods should be eliminated from the diet and replaced with whole grain foods, fruits, and vegetables.

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FOS
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Date: August 22, 2008 05:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: FOS

Fructooligosaccharides, which shall henceforth be referred to as FOS for obvious reasons, are sugars with chemical linkages known as osidic covalent bonds that resist enzymic hydrolysisis, and so are broken down by neither the salivary nor the digestive enzymes. In other words, they are indigestible.

However, before discussing the biochemistry further, let's have a look at what they can be used for. Your body depends upon certain bacteria for its health. These are essential to help break down and digest certain foods, and also to provide a resistance to disease and infection. FOS is what is known as a prebiotic, which used to feed these friendly bacteria. Just like any other living organism, bacteria require nourishment and while they get plenty of food from our own diet, especially from the fiber content, they find FOS particularly appetizing.

Because fructooligosaccharides cannot be digested, it passes unchanged into the colon, where these bacteria live. As they break down the FOS and live on it, they multiply, and create an environment in your lower intestine that is hostile to many harmful bacteria such as Clostridia and E. coli. However, it is not only these harmful bacteria that cause problems with your digestion since there many other agents that can interfere with the smooth functioning of your gastrointestinal tract.

People all over the world are continually suffering from both minor and very serious digestive problems, ranging from heartburn and upset stomachs to severe diarrhea, Crohn's disease, irritable bowel syndrome and even bowel cancers. There is a multitude of reasons for that such as the effects of aging, poor diet and bacteria from contaminated food. Organic foodstuffs do not last long in many warm countries, and while spices can be used to hide the taste, they are not always successful in killing off the bacteria.

Your health depends on a healthy digestive system, and when that is wrong then you will feel ill. If your digestive system is running below par, then you will not feel good, and could suffer from a wide range of symptoms, including tiredness, nausea, constipation, diarrhea, fevers and depression. The health of your intestinal tract in particular is often neglected, and most people need to do something to give it a boost and improve its, and their, overall health.

That is what FOS can do. And it can do more than just feed friendly bacteria: it can help you maintain regular bowel movements, maintain healthy blood sugar levels, maintain a healthy immune system, break down hormones and rebuild them again (it is useful for the relief of the symptoms of PMS) and to keep down the cholesterol and fatty acid levels in your blood. It is used to feed beneficial bacteria, not to replace them, and if you are on a probiotic supplement, you can take FOS along with it.

Fructooligosaccharides are also used as artificial sweeteners, and alternative names for them oligofructan and oligofructose. There are two classes of FOS, the first of which is produced commercially by the chemical or enzymic degradation of inulin, a polymer of D-fructose linkages terminated with D-glucose. This is produced commercially predominantly in Belgium and Holland, and it also occurs naturally in chicory and Jerusalem artichoke, and in lesser amounts in bananas, garlic, tomatoes and onions. The second class of FOS is produced mainly in Japan. This is produced by a process known as the transfructosylation of a B-fructosidase from saccharose or aspergillus niger, a black mould found on onions and grapes. This is basically the same as the first class, although the chemical bonds are in different places.

While they resist breakdown by enzymes, they are fermented in the colon by anaerobic bacteria, bacteria that work in the absence of oxygen. Because they are fairly soluble, they can be added to dairy products such as yoghurt and used to feed the bacteria contained in the yoghurt. In fact many supplements containing acidophilus bacteria are fortified with FOS: you drink the bacteria along with its food.

Although FOS is only now assuming increasingly popularity in the West, it has been used as a dietary supplement in Japan for many years. Some of the specific health benefits that FOS coveys by promoting the health of essential bacteria, are:

Calcium and Magnesium Absorption

There have been several studies that have concluded that FOS and inulin improve the absorption of calcium in the intestine of both animals and humans. The fermentation of the FOS by bacteria reduces the pH of the gut, which increases the solubility of these minerals and hence extracts more of them from food. The increased solubility also helps them to be more easily absorbed through the intestinal wall into the bloodstream. FOS can therefore help to maintain bone density and prevent osteoporosis.

Strengthened Immune System

By taking a supplement of FOS, you can increase the density of friendly bacteria in your gut fivefold in a matter of weeks. This crowds out harmful bacteria, and so the level of toxins in your body is reduced. Your immune system is allowed to work properly to fight of infection and disease without having to work hard on keeping down the harmful bacteria in your gut.

Promotes Regularity

Apart from being a food for bacteria, since it is not digestible FOS is also a soluble fiber that draws water into your colon, and so promotes easy transport of feces by the peristaltic pumping action of the intestinal muscles. It also absorbs excess water in the chyme and feces and so helps to prevent diarrhea. Furthermore, improving the health of the friendly bacteria also improves your digestive health that also promotes regularity.

Increased Energy

The fermentation of FOS by bacteria produces gases and acids. These acids help the body to produce energy, and although not a massive energy boost, when allied to the improved digestion it is significant.

All of these benefits and more suggest that FOS is highly recommended in the event of sporadic and chronic gastrointestinal problems. It is a natural substance that does not have a direct influence on your body's biochemistry, but promotes the health and reproduction of those bacteria that do have a significant influence on intestinal health. Add that to the added benefits discussed above, and FOS is one of these supplements that could almost be called essential.

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What Is Fiber?
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Date: July 21, 2008 02:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is Fiber?

Fiber often has been called roughage, as it technically is a food component that is undigested and processed through the gastrointestinal tract. Since it readily absorbs water, it helps to add to the bulk that is required in order to form a good bowel movement. Fiber is often described as a complex carbohydrate, which consists of the polysaccharide and lignin substance that often gives structure to the cell of a plant and is the portion of plant food that is not digested.

Fiber which is insoluble has the capability of passing through the intestines intact and unchanged. Unlike fats, carbohydrates, and proteins, fiber does not give the body nutrients or fuel for energy, and has no caloric value. Dietary fiber can only be found in plant components including vegetables, fruits, and whole grains. Primarily, there are only two types of fiber: soluble and insoluble, with some foods containing both types.

Soluble fiber is eventually digested in the large intestine, causing it to have limited bulking power. Soluble fibers dissolve in water and have often been linked to helping prevent blood sugar highs and lows, helping to lower blood cholesterol, lowering the risk of heart disease, helping to control high blood pressure, and encouraging friendly bacteria growth. Soluble fiber can be found in pectin, lignin, gums, mucilages, and other sources such as psyllium, beans, apples, pears, and oat bran.

Soluble fiber doesn’t usually seem like fiber. It is digestible and, when broken down, it creates a gel as it absorbs water in the intestinal tract. It does not bulk the stool to the extent of insoluble fiber, but it does slow down the rate at which food is digested. Soluble fiber is found in vegetables, particularly onions, bulbs, leeks, and asparagus, and also fruits, including dried varieties.

Insoluble fiber remains undigested for the most part and promotes a faster stool transit time. Insoluble fiber can keep the bowel clean and operative and also help to bind dangerous toxins and hormones in order to promote better excretion. Insoluble fiber also fosters regularity in the body, contributes to better digestion, prevents constipation, and helps to lower the risk of bowel disease.

Insoluble fiber is primarily composed of cellulose and hemicelulose. Cellulose is a non-digestible form of fiber, found in outer portions of vegetables and fruits. Bran or seed covering of whole grains is another type of insoluble fiber. Hemicellulose fibers remain unchanged and absorb water as they travel the digestive tract. They increase stool bulk and transit time, preventing constipation and conditions like hemorrhoids. Stalks, stems, peels, and fruit and vegetable skins are all made up of insoluble fiber. However, the insoluble fiber content of fruits is actually found in its flesh and stringy membranes, rather than its peelings.

The average person needs a good variety of foods that contribute to at least 35 grams of dietary fiber in our diet daily. Most foods contain both types of fiber, but the ones that are most fiber rich are not usually the ones that we commonly eat. Whole grain cereal, raw fruits and vegetables, split peas, beans, lentils, millet, and barley are the best sources of fiber. Unfortunately, statistics have shown that most of us only get 9 grams of fiber each day, if we are lucky.

Finally, fiber has the ability to increase fecal bulk by retaining water, decrease stool transit time, keep blood sugar levels more stable, lower blood serum and liver cholesterol, help prevent weight gain by slowing the rate of digestion and absorption and controlling hunger, expediting the removal of dangerous toxins, binding with bile salts to help decrease the risk of gallbladder disease and certain types of cancer, and creating the presence of healthier intestinal bacteria.

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DIM For Estrogen Balance
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Date: July 10, 2008 03:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: DIM For Estrogen Balance

Diindolylmethane from broccoli can help with estrogen balance: There is plenty of evidence to suggest that, but before discussing the whys and wherefores, let's first have a look at the substance, where it comes from and why it should have any effect on estrogen or its balance.

Diindolylmethane is an indole contained in brassicas such as broccoli, cabbage, kale, brussel sprouts and cauliflower. It is a dimer of indole-3-carbinol, which is itself formed by the autolytic degradation of glucosinolate glucobrassicin which is found in brassicas. Both this and the dimeric diindolylmethane are currently being tested for their antioxidant, anticancer and antiatherogenic properties, although this type of research has been mainly made on animals. When the cell walls of brassicas are ruptured, the enzyme myrosinase is released, that breaks down the glucobrassicin.

Because diindolylmethane is oil soluble it is more bioavailable to the body in the presence of vitamin E and other lipophilic substances, and these are normally included in oral supplements. However, back to estrogen and its effects upon human estrogen balance. Estrogen is the name for a group of steroids that function substantially as the female sex hormone. They have many effects on the body, including regulation of the menstrual cycle, breast development and promote the formation of secondary female characteristics such as reduced height and muscle mass.

Estrogen is also present in the male, where it regulates several factors pertaining to the reproductive system. It does not, however, take part in the process that determines sexual desire. If all of these properties are considered it would seem logical to believe that estrogen levels could be used to control weight increase, although claims that it can be use to enhance sexual performance seem ill founded: based more on hope than on science!

What science appears to have found, however, is that estrogen dominance, due to an imbalance between estrogen and progesterone levels in the body, can give rise to increased weight, and even obesity, in women. It can also lead to uterine, ovarian and breast cancers, and cervical dysplasia which, while not cancer, can give rise to cervical cancer if not treated. Estrogen imbalance, therefore, is not good news and something to be avoided if it possibly can. So what can be done to avoid it?

The answer is to find a hormonal balance, and this is where diindolylmethane (DIM) comes in. The substance has been found to have a positive effect on the balance between estrogen and progesterone, although eating broccoli will not be sufficient to do the job properly. Insufficient DIM is released by breaking the cell walls of broccoli through chewing to have much effect on the balance, about a kilo of broccoli a day being needed to have any noticeable effect. It is the diindolylmethane supplements that are able to have the desired effect in restoring the hormone balance and eliminating the undesirable effects of estrogen imbalance.

But why should estrogen imbalance occur? What are the factors that cause this dangerous condition, and if it is so common how did our ancestors manage without today's science? The answer to the second question lies in that to the first, but before we discuss that don't go thinking that your ancestors managed through thick and thin. Perhaps yours did, but your life expectancy is significantly greater than that of your parents when they were born. In fact, you don't have to go too far up your family tree to when you would be doing well if you hit forty! So the argument about your ancestors doesn't wash.

In fact, an estrogen imbalance can be caused by several factors: a slow estrogen metabolism that leads to an excess of estrogen because it is not broken down quickly enough is common, but far more common is the effect of pollutants such as pesticides, car exhaust fumes, emulsifiers, household cleaners and even some soaps. They contain chemicals known as xenoestrogens that our body believes to be real estrogens. They can stick to estrogen receptors on healthy cells, and can also prevent true estrogen from binding to the cell it should bind to. This results in an increase in free estrogen that cannot bind to the estrogen receptors that it should. Your ancestors did not have these problems with such 'estrogen mimics' and so managed just fine.

There is also the fact that estrogen can be broken down in the liver by means of two different routes: one leads to a form of estrogen that metabolizes to provide many benefits, such as strong bones and a reduction in heart disease, while the other has the opposite effect of causing cancers, depression, osteoporosis and problems with your immune system. That is by no means the full list: you don't want to see that, believe me!

You might think that if estrogen is dominant over progesterone, then taking progesterone would resolve the problem. It would seem to be a good cure. In fact, it is not a good idea since progesterone can be metabolized into yet more estrogen, making the problem even worse. The real answer is to take a supplement containing the substance that solves the problem by changing the estrogen metabolism pathways in the liver: diindolylmethane. More of the so-called "good" estrogen metabolites are formed, and less of the bad. The actual estrogen levels are not changed, but the way in which the excess estrogen causes harm is changed. That way, it doesn't matter what the imbalance is, the estrogen cannot do ham to your body.

DIM possesses many potential positive benefits when used as a supplement. It can reduce your chances of getting breast, cervical and ovarian cancers, and also acts as a strong antioxidant, and helps to strengthen your immune system. It might help you to lose weight, but more studies are needed before this can be claimed conclusively. However, there is evidence at the moment that it has a weight reducing effect.

Its effect on sexual health is largely unfounded, but the effect of a placebo in this area can be astounding: that indicates how much psychology has to do with sexual performance. Nevertheless, the known and projected benefits of diindolylmethane are so significant that taking a supplement would seem a reasonable thing to do, and although your mom was right about you eating your broccoli, brassicas alone are not a rich enough source for a significant effect.

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How Important Is It To Have Proper Digestion
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Date: July 09, 2008 11:46 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Important Is It To Have Proper Digestion

The part played by food in the health of your body is to furnish it with the nutrients needed for the biochemistry that keeps you alive. The digestive process breaks the food that you eat down into a form that can be absorbed by your bloodstream, and from there to your liver which is your body’s chemical plant. That is where most of the biochemical reactions of your body take place, such as the manufacture of bile needed to break down fats during digestion.

Most people do not take this into account when eating, and in today’s hectic world nourishment is the last thing on their minds, yet the one aspect of their lives that can provide them with the energy to carry on as they do. They eat to get rid of the feeling of hunger, and any old thing will do: a burger or a pizza, but rarely an orange or some cheese on wholegrain bread.

Poor eating habits lead to poor digestion, which in turn leads to poor extraction of the nutrients from what we do eat, and therefore malnutrition. Yes, malnutrition! It is possible to suffer from that even though you fill your belly every day. It’s not the filling that matters, it’s what does the filling and how well it is digested. Proper digestion is very important to every living creature on this planet. The first step in ensuring that have a proper digestion function is to assess the quality of the food that you eat:

a) What nutrients does your food contain, and

b) Have you sufficient of the proper enzymes needed to break it down so that these nutrients can be extracted?

Nourishing meals are just as easy to find and eat as junk foods, and it is just as easy to a breakfast containing a high protein and fat content as it is to eat a chocolate biscuit. A hard boiled egg with whole meal toast and yoghurt isn’t difficult to prepare for breakfast, and some tuna, or cheese and whole meal crackers make a nutritious lunch. These foods are easier to digest than the greasy high-fat foods that most people eat at lunchtime.

Proper digestion requires relaxation, and eating when stressed or in a hurry creates the wrong pH conditions in your stomach, with hydrochloric acid production being suppressed and the production enzymes by the liver inhibited. Enzymes are essential to your health, and are types of protein that enable most biochemical reactions to take place. Without the proper production of enzymes, your food will pass through your body largely unchanged, and this indigestion can not only give you stomach pains but also weaken you because the nutritional value of your food is not being realized.

You should take the time to eat, and not try to eat on the job: that is why so many high fliers end up with ulcers. Take time to chew, and mix your food with saliva which itself contains the enzymes amylase and lysozyme. Amylase breaks down starch into sugars, while lysozyme inhibits the growth of oral bacteria. The digestive system therefore begins in the mouth when you chew your food. The breakdown of food into smaller particles also produces more surface area from which the nutrients can be absorbed.

Enzymes are very important to proper digestion, and your diet should include enzyme-rich food such as tropical fruits (pineapple and bananas), honey, and many vegetables. Yoghurt and lacto-fermented foods are also rich in enzymes, and many cooked foods also contain enzymes. An enzyme supplement can also be taken to top-up what you eat, and make up for any enzyme deficiency in your diet. Processed foods are fairly empty of good nutritional value, particularly enzymes, which is why so many people are so overweight: their food is a nutritional desert and their body keeps craving for food that leads to eating binges.

For your food to be properly digested your stomach acid has to be at a certain pH. If you drink too much liquid when eating then the acid will be diluted, and you will not properly digest your food. A glass of water is fine but two or three pints of beer, or a gallon of fruit juice, will dilute the hydrochloric acid concentration in your stomach, and it will not be able to break down your food. Consequently, your digestive system loses much of the nutritional content of what you eat. Restrict heavy drinking of liquid to about two hours before and two hours after eating each meal for maximum efficiency. Many people find that they have to take not only vitamin and mineral supplements to replace those which are lost through inefficient digestion, but also other supplements such as enzymes and extra proteins.

When food is processed or cooked, the process destroys enzymes. Since the body stores only a limited supply of enzymes, eating well cooked or highly processed foods continuously, places great strains on the enzyme reserves, and ultimately the metabolic enzyme reserves have to be used in order to digest your food. This diverts them from their proper purpose, and many of the functions of your body are disrupted.

For example, your lose energy and your immune systems begins to weaken, making you feel tired and more susceptible to illness and disease. You should therefore try to eat foods rich in enzymes, or use an enzyme supplement. Natural raw foods are an excellent addition to your diet, and salads and fruit should be regular components of your meals. Obviously you must eat some cooked foods, but that does not mean that you should avoid eating fresh raw fruits and vegetables altogether. That is a recipe for a dietary disaster.

Enzymes are extremely important components of your digestive system, as is dietary fiber. In fact if you eat a diet containing dietary fiber, some raw fruit and vegetables, and protein, either cooked or uncooked, you will be giving your digestive system a boost. If you are unable to maintain that, then enzyme supplementation, together with general multi-vitamin and mineral supplement daily, should help you to maintain a healthy digestive system. However, fiber is essential since without it you will become constipated, especially if you consume a lot of pulpy foods that mainly consist of water.

It is extremely important that you have proper digestion of the food that you eat, and that your body makes the best use of the nutrients that it contains. To achieve this, you have to maintain the correct pH of stomach acid, and eat foods with the nutritional content required by the human body. This means not overcooking a balanced diet containing protein, fiber, enzymes and other nutrients such as vitamins, minerals and phytochemicals (plant-based chemicals).

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Garcinia Cambogia
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Date: July 08, 2008 03:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garcinia Cambogia

Garcinia cambogia is a small tree bearing a small pumpkin-like fruit of the citrus family, and is steadily appearing in an increasing number of weight loss supplements. It is indigenous to parts of Africa and Asia, and the rind is commonly used in Indian cookery.

Although the fruit is particularly sour to the taste, it is used in form of an extract of the rind and claimed to act as an appetite suppressant and also to increase the body’s capacity to metabolize fat. Although there are conflicting claims being made about its efficacy, or lack of it, research shows that it definitely has promise as an agent to prevent and fight obesity and its use is steadily increasing in this respect.

The active ingredient is hydroxy citric acid, otherwise known as HCA, contained in the form of the potassium and calcium salts of the acid in the aqueous extract of the garcinia cambogia rind. It forms up to 30% by weight of the rind. It is tasteless and odorless, and so far found to have no toxic effects on humans. Animal studies have also been generally favorable.

HCA works in two specific ways both to reduce the desire to eat and to inhibit the storage of fat in the body. In each case, as with so many supplements that have an inhibitory effect on a physiological or psychological function or on a metabolic process, it involves an interaction with enzymes.

Citrate lysase is an enzyme in the body that helps to prevent lipogenesis and instead promotes the conversion of carbohydrates into fat. When this enzyme is inhibited from carrying out its intended part in the body’s metabolism, the process of carbohydrate oxidation is boosted, or, in other words, the excess carbohydrate is burned off, or changed into energy.

More fats could also be expelled unchanged from the body, but irrespective of that the end result is that less carbohydrate tends to be converted to fat. Garcinia cambogia, however, has not been found to reduce the body’s uptake of essential fatty acids which are necessary for health. Had this occurred, you would feel a raging hunger as opposed to the appetite suppressing properties the extract is claimed to have.

The oxidation of carbohydrates can also lead to thermogenesis, or the boosting of the metabolism by increasing your body temperature. An increase in the metabolic rate helps weight reduction through an increased calorie demand while your body is at rest. However, that is not the only way in which the HCA extract works to help reduce your weight, or at least help to maintain it at a healthy level. Let’s return to its specific appetite suppression properties.

Serotonin (5-hydroxytryptamine) is a neuroreceptor found in the central nervous system. It has many regulatory effects on the body, one of which is appetite. Although it is by no means the only chemical in the body that has an effect on the appetite, serotonin is a significant factor. As you get hungry, serotonin is released in the hypothalamus, an area of the brain that regulates sleep and eating. The release of serotonin increases when you see and or smell food. It is the agent that starts canine salivation, and a ravenous hunger in those that have no immediate access to food.

It also causes you to snack, and, as you eat, the serotonin level in the hypothalamus continues to increase until it reaches a point where it provides the hypothalamus with a feeling of repletion or satisfaction. You then stop eating. So the more serotonin is produced, the quicker you stop feeling hungry.

Garcinia cambogia extract has the effect of stimulating the emission of serotonin into the hypothalamus, and so suppresses your hunger quicker. You don’t stop eating altogether, but attain that feeling of satisfaction much quicker and so tend to eat less with each meal. This can not only help you maintain your weight at a healthy level, but also to reduce weight in the obese.

Although the extract can work through each of these mechanisms, it does not have such a significant effect on a very fatty diet. It can help if you switch to a relatively healthy diet, lower in fats, but the effect might not be strong enough to compensate for a poor diet in terms of fat content.

Studies have indicated an anti-oxidant activity that likely comes from the xanthones and xanthone derivatives that are also contained in the fruit. In fact there are other recorded uses of garcinia cambogia, and it has been used in traditional Indian medicine to treat fevers, dysentery, open wounds, ulcers and tumors.

According to a study carried out for the National Cancer Institute there is no documented toxicity effects on humans, and there is no regulation regarding the use of garcinia cambogia. It has not been evaluated by the FDA.

However, there are contra-indications in the case of pregnant and lactating women, more as a safety measure than for any particularly known risk. Alzheimer patients should avoid taking HCA since there is a possibility of it promoting the synthesis of acetylcholine in the brain, and its glycemic action renders it unsuitable for diabetics.

Conversely, this same action is a positive benefit by reducing the craving of healthy adults for sweet foods. However, HCA is frequently taken in combination with chromium due to the latter’s positive effect on the regulation of blood sugar levels. Nevertheless, diabetics should avoid any supplement containing chromium without professional medical advice.

The supplement should be standardized on the HCA content, and an average dose is around 500 mg – 1000 mg of 50% extract a day. However, this varies, and the most important aspect of such extracts is that when changing brands; be sure to compare the strength of the relative extracts and change your dosage accordingly.

Although the benefits of garcinia cambogia to those seeking to lose weight are debated, there is ample evidence to suggest that a regular intake of the extract is beneficial – and not only with respect to the maintenance of healthy weight.

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D-Ribose
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Date: May 17, 2008 10:07 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: D-Ribose

Discovered by Phoebus Levene in 1905, D-ribose is a monosaccharide, and is a component of RNA that is needed for genetic transcription. It is a stereoisomer of ribose, and although not regarded as an essential nutrient since it is synthesized in the body, it is essential for life. It also takes part in human metabolism, helping to generate energy from food, and is a component of all living cells – animal or vegetable. It is contained in ATP and NADH and we could not live without it.

Because it is contained in all living organisms, D-ribose is a common component of the human diet, and required as a supplement only for specific needs. It for this reason that the human species developed and survived: the chemicals needed for life are either commonly found in nature or are manufactured by the body itself from other raw materials which themselves are common in our diet. The other stereoisomer is L-ribose, and this plays no part in human metabolism.

Energy is needed not only to enable us to walk and to run, but also to drive every part of human physiological activity, and all of the physical and chemical processes of life. Because of its nature energy cannot travel round the body in our bloodstream as if were a chemical entity, but must be released or generated where and when it is needed. For that reason every cell in our body contains an area called the mitochondria in which energy is generated. The molecule of energy, if there is such a thing, is called ATP, or adenosine triphosphate.

ATP controls the production of energy everywhere in the body, and allows muscles to contract and relax. This muscular activity is responsible for all movement, including the circulation of our blood through heart contractions, the diaphragm movement that creates the vacuum that allows us to breathe, and the operation of the digestive system by means of the peristaltic motion of the esophagus and the intestines. Each of the two ways in which ATP is generated involves D-ribose.

One is by means of D-ribose being used to produce new ATP, and the other is the recycling of used ATP. In the latter, D-ribose and ATP react to form ADP (adenosine diphosphate and D-ribose-5-phosphate with the release of energy. This diphosphate then reacts again with the ADP to produce new ATP and D-ribose. The reaction is catalyzed by an enzyme known as a ribokinase, a phosphotransferase that specifically catalyzes reactions involving phosphorus groups with an alcohol receptor group.

The heart muscle is operated by means of the calcium pump that depends upon both calcium and ATP for its operation. When ADP and phosphate are created by the effect of calcium and ATP coming together, then energy is provided to the muscle fibers of the heart. ADP then reacts with the phosphate and D-ribose in the presence of magnesium to reform the ATP. ATP is therefore essential for the continuation of the pumping action of the heart that maintains life in all mammals.

D-ribose is also part of the base of RNA and DNA, without which there could be no life. Because the cardiac muscle is easily depleted of ATP, the presence of D-ribose is of extreme importance and it has been proved that cardiac failure begins with the reduction in energy levels of the heart muscle that can be brought about by a lack of ATP in the muscle cells.

An important property of D-ribose is that it is unchanged by the liver, which is the chemical plant of your body in which a large part of the biochemistry needed for life takes place. This means that D-ribose can be taken in the diet and pass through the liver virtually unchanged, and then be transported in the bloodstream to where it is needed for the maintenance of ATP levels. That is why D-ribose is frequently given to treat heart attacks: because it can rapidly replace lost ATP and enable the calcium pump to get to work and keep the heart beating at its normal strength. Maintenance levels of this important sugar would not go amiss.

However, there are other uses to which the body can put this marvelous substance. Among these is the body’s ability to form Coenzyme A from it. This coenzyme is needed in the body for the breakdown of fatty acids, and many other chemical reactions, and also provides the raw material for many other necessary substances in human biochemistry.

Patients with low energy levels can frequently fail to be able to recover from illness. This is because that when illness stresses your body, your mitochondria become overwhelmed with work and begin to fail to produce sufficient ATP to keep the body going. Naturally, as your energy level drops, and your body cells are unable to respond to this, then the condition you are suffering from gets worse, and become stronger leading ultimately to possible death. Your immune system is put under a great deal of stress that uses up what little ATP you have left.

That is why when people start to get really ill, they tend to fade very rapidly: not because of the spread of the disease, but through a reduction in the ATP needed to provide the energy required for the body to fight the disease. Without an adequate supply of energy, your body would rapidly fade.

By taking a D-ribose supplement that passes unchanged right into your bloodstream and taken to where it is needed most, you body can rapidly generate sufficient ATP to keep up the fight against the agent that is making you ill. Your immune system is given a massive energy boost, and more importantly, your heart is kept beating. D-ribose is the answer to the prayer of many sick people, and also to athletes and bodybuilders needing quick bursts of energy. But what did they use before D-ribose was discovered to have the properties that it has?

At one time, it was adenosine monophosphate (that’s right, not ATP or ADP, but AMP) that was administered intravenously to those suffering from chronic fatigue, this substance being synthesized to ATP in the body over a period of time. However, it take a lot of time to be effective, and the injections had to be made daily into the muscle tissue, so it fell out of favor.

Then came an ATP supplement that could be taken orally, but the side effects were unpleasant, and that too went out of favor. However, towards the end of the 1990’s D-ribose was found to overcome all of these disadvantages, and not only be able to be taken orally, but also to work almost immediately by providing the mitochondria with a direct source of the sugar they need to generate energy.

It is now one of the most popular energy providing supplements on the market, and also a remedy for chronic fatigue that helps the patient to overcome energy-sapping medical conditions both directly and by providing the immune system with the energy needed to keep it operating effectively against masses of invading bacteria and viruses. There is nothing better than D-ribose for providing you with the energy boost that you need, whenever you require it, either to provide energy for your sport or to help you overcome illness.

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B Vitamin Supplements
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Date: May 07, 2008 03:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: B Vitamin Supplements

The fact that B vitamins have had to be coenzymated before they can be used by your body has been known for some time, but it is only over the past few years that they have been made commercially available in that form. Before we discuss the B vitamins in their coenzyme form it might be appropriate to discuss what coenzymes are and how they differ from ordinary enzymes.

An enzyme is like an organic catalyst: it takes part in biochemical reactions by allowing such reactions to take place, but itself remaining unchanged. All enzymes are proteins formed in your body from amino acids and other protein material. A coenzyme, on the other hand, is somewhat like an enzyme for the enzymes, in that it is needed for the enzyme to do its job. Without a coenzyme, many enzymes could not promote the biochemical reaction it is responsible for.

The B vitamins are all water soluble, which means that they are readily excreted and it is not impossible that if you take a B vitamin supplement, the whole lot will be immediately excreted in your urine if not used by your body. Whether they are or not it is a fact that your body can quickly become depleted of the B vitamin group, especially if you drink a lot. Alcoholics in particular are frequently vitamin B deficient. Although the liver can store unused vitamin B, they are only very small quantities and insufficient to prevent a deficiency.

A deficiency in the B vitamins can cause a wide range of unpleasant conditions that are rapidly remedied with supplements. Pellagra is due largely to a deficiency in Vitamin B3, and causes hair loss, horrible skin lesions and many other side effects that you don’t want to know about. Vitamin B12 deficiency can cause loss of memory, and is common in alcoholics and some vegetarians (vitamin B12 is animal derived). Other symptoms of a general B vitamin deficiency include exhaustion, heart palpitations, fibrillation, anxiety, restlessness, attention deficit disorder and many, many more.

It is not pleasant so you make sure that take enough vitamin B in your diet: dietary sources are far superior to pills although supplements will help you get over the symptoms of the deficiency until your diet takes over. Supplementation is also a good way to maintain a regular supply of vitamin B complex irrespective of your diet. The effects of a deficiency are so bad that a regular supplement is well worth taking.

However, back to coenzymes and why they are needed for the metabolism of B vitamins in your body. Most B vitamins are, in fact, coenzymes themselves. Keep in mind that the definition of a vitamin is an organic substance that is essential for the normal health of your body. If you lack even one vitamin, your health with suffer and eventually you will be likely to die. That describes all of the B vitamins perfectly, and they also just happen to be coenzymes. This is not coincidence, of course, and their biochemistry must have been recognized before the concept of coenzymes was formulated.

The B vitamins proper consist of eight distinct proteins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine), B9 (folic acid), B12 (cyanocobalamin), and biotin and pantothenic acid. They are all essential components in human and animal metabolism, and most are also coenzymes.

Every cell in your body depends on B vitamins for its existence, which is why pregnant women should include a good supply of them in their diet, especially folic acid (B9). They are essential for the cellular development of the fetus. Folic acid is necessary for the synthesis of nucleic acids that allow cell growth and the production of red blood cells. However, not one can be placed in importance above any other since they are all essential.

With respect to the coenzyme factor, the vitamin B coenzymes are responsible for many of the biochemical reactions upon which life depends. Coenzyme B-12 for example is essential for two types of reaction that it catalyzes, one being a hydrogen atom exchange with alcohol and amine functional groups, the other being connected with methyl group transfer between molecules.

In humans, the first of these is responsible for an essential step that results in energy being metabolized from fats and proteins in the mitochondria and the second for DNA production in cells that is indirectly responsible for growth. Each of these is why a vitamin B-12 deficiency leads to excessive fatigue and also a lack of fetal growth (although folic acid can make up for the latter deficiency).

Thiamine (Vitamin B1) is a coenzyme for the metabolism of carbohydrates to energy. In the body it is present in the form of thiamine diphosphate, a coenzyme that assists in the decarboxylation of pyruvate as part of the citric acid cycle, otherwise known as the Krebs Cycle, that takes place in the mitochondria and is responsible for the generation of energy through aerobic respiration.

Another coenzyme that is involved in the Krebs Cycle is formed in the body from Vitamin B3, or niacin. This coenzyme, nicotinamine adenine dinucleotide, has a redox potential and can store energy for use later on. Vitamin B5 can be converted in the body to Coenzyme A that not only breaks proteins down into individual amino acids, but also takes part in the first part of the Krebs Cycle. There is a common pattern emerging here where the B vitamins have an important part to play in the generation of energy from fats and carbohydrates.

Similarly, Vitamin B6 is present in the body as the coenzyme Pyridoxal 5'-phosphate that helps to break down the body’s emergency energy store, glycogen, into energy when needed.

In these ways, and more, the coenzymes created in the body from the B vitamins help many of the reactions of life to take place, and without these coenzymes life could not exist. Hence the importance of the B vitamins themselves, and any deficiency could be disastrous to the metabolic processes that generate energy and keep you alive. It is not just the energy needed for exercise and normal human activity that will be compromised, but also that which keeps the heart beating and your diaphragm moving to allow you to breath.

Without a doubt, a Vitamin B supplement is one of the most valuable of all the vitamin supplements, and they are available in many forms. You might also find some of the B vitamins in their coenzyme form, though some of them may be unstable. However, whatever form they are taken in, Vitamin B complex should be one of the first on your vitamin supplement shopping list.

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Don’t Live With Pain, Live Pain Free – Curamin Is The Answer
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Date: April 24, 2008 04:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Don’t Live With Pain, Live Pain Free – Curamin Is The Answer

Fact, more than 50 million Americans suffer from chronic pain. Chronic, meaning pain that continues daily, weekly, monthly, and yearly, pain may which never end with out help. According to the Journal of the American Medical Association, pain is the primary reason people seek the advice of a doctor or health practitioner, and the number one reason people take alternative medicine.

A new revolutionary dietary supplement for pain and inflammation is now available on the market. Introduced by Terry Lemerond, this new formula called Curamin has changed thousands of lives. This formula contains three anti-inflammatory herbs and one amino acid that can help one live a more normal pain free life.

The first ingredient: Curcumin is a substance found in turmeric. Curcumin contains curcuminoids which have been shown to reduce inflammation and pain. Turmeric is an ayurvedic herb discovered in India and brought over to the United States has demonstrated amazing results. Turmeric has been cooked with and used as a medicine for over 2000 years. The active ingredient in turmeric is curcumin which has demonstrated six important properties. Curcumin has anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, and anti-cancer properties. As you can see this herb has made quite a name for its self.

The second ingredient is Boswellia. Boswellia contains boswellic acid which is the active ingredient in this herb as well. This herb has also demonstrated its natural ability to fight inflammation and more. Research suggests that Boswellia’s active ingredient can actually modulate the expression of the genes involved in the body’s inflammation response thus giving itself an anti-inflammatory name.

The third ingredient is DLPA an amino acid also known as DL Phenylalanine. This amino acid can help the body product more serotonin in the brain. D-phenylalanine can actually help reduce chronic pain through the production of serotonin. Serotonin helps one feel more relaxed and level headed this is something everybody needs when it comes to pain that drives them crazy all day long. Those people consuming MAO inhibitors and anti-depressants need to avoid DLPA with out a doctor’s supervision.

The forth and last ingredient in Curamin is nattokinase. Nattokinase is an extract from fermented soy cheese. For thousands of years natto has been consumed by the Japanese people with out even know the health benefits of its consumption. Nattokinase can help the body fight blood clots, thin the blood, and fight pain and swelling.

This new formula Curamin has the three top herbs that fight inflammation in the body, when combined with DLPA, this product has the amazing ability to fight pain by attacking the source of pain, inflammation.

Recommended doses for curamin are 2 capsules in the morning and 2 more capsules in the evening after work. Some may need a stronger dose at first, this is where one should take 4 capsules at one time in the morning for the first few days then step back to 2 in the morning and 2 in the evening.

We have free samples available upon request and back the curamin product with a 100% satisfaction guaranteed. So if you are un-satisfied, just return the unused portion of the product for a full refund of the purchase price minus shipping costs.

So what are you waiting for? Are you ready to live pain free? Give curamin a try!

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Blue Green Algae a Super Food that is Foods Packed With Nutrients. Vegetarian Friendly
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Date: April 11, 2008 11:24 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Blue Green Algae a Super Food that is Foods Packed With Nutrients. Vegetarian Friendly


Blue green algae are not only an excellent source of amino acids and protein, but are generally considered to be the king of superfoods. It contains just about every nutrient you could think of, and has the added advantage of being completely natural and easily assimilated into the body.

In the USA it is harvested in Oregon, in the upper regions of the Upper Klamath Lake, although it is also available in many other parts of the world. Blue green algae are about the best source of vegetable protein and amino acids available to the human diet, although are now generally used as a supplement rather than as a primary food source.

However, in spite of its name, it is not an alga at all: it is a bacterium: Aphanizomenon flos-aquae (AFA), known as cyanobacteria, after the Greek for blue. Nevertheless, bacteria or not, blue green algae offer exceptional nutritional benefits and also health benefits to people suffering from certain conditions. Here are the best of its benefits:

1. It is natural and therefore easily assimilated and digested. You get a very high useful yield from its nutrient content, unlike other foods where a large proportion can be passed through the gut unchanged. In fact a large proportion of the food you eat passes through your body unchanged, although that is mainly due to a lack of chewing!

2. It is very high in protein, and helps to maintain healthy hair, nails and skin. If you are on a vegetation diet this is an ideal source of non-animal protein (unless you class bacteria as animals!). If you want numbers, at least 60% of the solid content of this material is vegetable protein human-ready for use.

3. It is packed full of enzymes that aid digestion, and so ensures that not only is it itself fully digested, but also that you get the most nutritional benefit from any other foods you eat. A lack of enzymes is very common in the western diet, especially the North American diet, and if you take a regular supply of blue green algae, then you need not also take enzyme capsules.

4. It possesses cleansing and detoxifying properties, and so helps to reduce the incidence of headaches and allow you better and more restful sleep. Toxins can act on your body to cause pain, and is associated with the free radicals discussed below.

5. It is very high in antioxidants that destroy the free radicals in your blood and tissues. Free radicals destroy body cells and can seriously damage your health. Among the health benefits that blue green algae provide due to its antioxidant properties are:

a) It supports the immune system and helps to prevent inflammation in your joints. It also enables you to fight off bacterial and viral infections quicker. b) It maintains the integrity of your body and skin cells, and reduces cell damage by free radicals. This has an anti-aging effect and preserves the youthful appearance of your skin, resisting wrinkling and maintaining its firmness. c) Blue green algae help to prevent the free radical oxidation of the LDL lipids that transport cholesterol that cause the atherosclerosis that can lead to heart attacks and strokes.

6. It provides you with energy through its effect on your body’s metabolic conversion of blood glucose to energy within the mitochondria. This is partially due to its antioxidant effect and partially to the nutritional content of the bacteria. The bacteria are also a rich source of glycogen that is your body’s store of emergency energy. Your liver can use the bacteria to biosynthesize its own store of glycogen that your body can use if called upon for a sudden burst of energy.

7. The amino acids it contains are of low molecular size, and can cross the blood-brain barrier. It provides nutrition to the brain, and its high chlorophyll content helps to purify the blood. Its high content of trace minerals and naturally chelated minerals renders them extremely bioavailable, and able to provide a high degree of nutrition to the brain and other organs of the body. Blue green algae contain rhamnose that helps nutrients to cross from the blood to the brain, and then to the brain cells that need it.

8. Blue green algae have been shown to help memory and mood. This is likely due at least in part to its fatty acid content, and its effect on serotonin levels.

These eight benefits are more than any other individual food source can provide, and in themselves justify the claim that blue green algae is the best individual food source there is. However, when we have a look at the active ingredients, and nutritional content of the bacteria, then it seems even more impressive. There is more to blue green algae than just a few vitamins and minerals. You can get these in any multivitamin supplement: this stuff is completely natural and all of its ingredients are completely compatible with the human digestive system.

Many of the synthetic vitamins you find in boxes and tubs are only partially absorbed due to the form they are in. Either that or they need the presence of other substances before they can be assimilated. An example is calcium, which is next to useless without magnesium and vitamin C also being present to allow it to be incorporated in the structure of the bones and teeth. With blue green algae, every combination of substances that nature needs for them to work properly is there. Everything gets used and everything has a role to play.

The amino acids and proteins have already been mentioned, and these unusual bacteria contain all of the trace minerals that are necessary for the amino acids and proteins to be properly used. It also contains a large quantity of beta-carotene (a natural Vitamin A precursor and strong anti-oxidant), and is also rich in Vitamin B-12 that most vegetarians are deficient in. It is therefore the perfect food for vegetarians and vegans.

If you understand the health benefits of omega 3 and omega 6 fatty acids, which blue green algae are also rich in, then you will understand how a foodstuff containing these fatty acids and all of the other nutritional substances listed above could be regarded as a ‘Superfood’.

Blue green algae is probably the richest food available commercially to humans, but before you use it you should ensure that the content of blue algae in the supplement you purchase is clear and that you are purchasing a standardized amount in what you are purchasing.

Otherwise, it is difficult to see how anybody could go wrong with blue green algae, since it is indisputably an excellent source of protein, amino acids, vitamins and much, much more.



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Fat Controls our hunger centers in the brain!
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Date: April 04, 2008 11:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fat Controls our hunger centers in the brain!

The main cause of any chronic disease of aging including Type II diabetes, CV disease, obesity, osteoporosis, and cancer are all caused by miss communication between signals that tell your body how to turn energy into life and the brain. The two most important signals that we know of today are given by the hormones insulin and leptin.

Leptin is an extremely powerful and influential hormone that is produced by fat cells. It has totally changed the way scientific researchers look at fat, nutrition, and metabolism in general. Before leptin’s discovery in 1994, fat was regarded as strictly an ugly energy store that most everyone was trying to get rid of. However, after it was discovered that leptin is actually produced by fat, fat became an endocrine organ similar to the ovaries, pancreas, and pituitary, as it influences the rest of the body, especially the brain.

Leptin is the most powerful regulator known to date of eating and reproduction. Your fat tells your brain whether you should be hungry or eat and make more fat, whether you should reproduce and make babies, or whether to maintain and repair yourself. It can then be stated that instead of your brain being in control of your body, your body, especially its fat and leptin, controls your brain.

Throughout history, it has been in ones best interest to store some fat to call upon during times of famine. However, it is also just as bad to be too fat. For most of our history, it was necessary to run, hunt, and avoid being prey. Therefore, fat storage had to be highly regulated and it still is. When a person typically tries to lose weight, the body tries to gain it back, resulting in what is commonly known as yo-yo dieting. Because of this, it has long been theorized that there is a “set point” and there must be a hormone that determines this.

Science now believes that leptin is that hormone. So in order to break the yo-yo cycle, one must control leptin. If a person is getting too fat, the extra fat produces more leptin that is suppose to tell the brain there is too much fat stored and the excess should be burned. Signals are then sent to the hypothalamus to stop being hungry, stop eating, stop storing fat, and start burning off some extra fat. Controlling hunger is a major way that leptin controls energy storage. Hunger is a very powerful drive that will make you do all you can to eat if it is stimulated long enough.

The only way to eat less in the long-term is to not be hungry and the only way to do this is to control the hormones that regulate hunger. The primary hormone that does this is leptin. It has recently been found that leptin not only changes brain chemistry, but can also rewire the neurons in areas of the brain that control hunger and metabolism to do its bidding. The inability of the body to hear leptin’s signals plays significant and even primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, cancer, and even the rate of aging itself.

In a process called glycation, glucose reacts with protein which results in sticky, sugar-damaged proteins called advanced glycated end products, or AGEs for short. When protein is damaged, it can’t function or communicate properly. AGEs promote excessive inflammation and free radical damage. AGEs and free radicals from oxidation are two of the major molecular mechanisms that cause damage which leads to aging. AGEs cause skin and the lining of arteries to wrinkle and inflame, which contributes to plaque and heart attacks. They can also promote the formation of cataracts and macular degeneration leading eventually to blindness.

The glycation process has also been connected with the destruction of proteins and nerve cells that may lead to Alzheimer’s disease, memory loss, and a variety of neuropathies. Glycation and oxidation are two of the major molecular mechanisms where damage accrues, disease occurs, and death results. High blood sugar can suppress your immune system, making you more vulnerable to infection and cancer. Highly aggressive cancers outpace the availability of oxygen and therefore must use an anaerobic fuel, in the form of glucose. By consuming glucose (sugar), we feed cancer. Lastly, high blood levels of sugar form non-fiber carbohydrates and excess protein send leptin and insulin levels upward.

If there is a known marker for long life, it is low insulin levels. Insulin’s purpose is not only to regulate blood sugar, but to store excess energy for future times of need. Insulin also lowers blood glucose levels as a side effect from storing it away, not regulating it. Today, high glucose is quite normal, as our insulin levels are typically much higher than they were among our ancestors. When you are constantly bombarding your cells with insulin, they become insulin resistant. This causes insulin levels to rise, creating a hormonal derangement that has a catastrophic effect on the metabolism.

High insulin contributes to making you fat because it tells your cells to store nutrients as fat rather than to burn it. Repeated high levels of insulin cause insulin resistance. The more fat the body accumulates the more leptin the body can produce so fat works against to slow down insulin production causing insulin resistance..

High insulin causes the retention of sodium, fluid retention, excretion of magnesium, elevated blood pressure, cognitive heart failure, blood clotting, and arterial plaque formation. Heart attacks are much more likely to happen after a meal that is high in carbohydrates than after one that is high in fat. This triggers a stress response which can cause arterial spasm, constriction of arteries, elevated blood pressure, irregular heartbeat and sudden death. Insulin resistance along with low magnesium keeps you from metabolizing important fatty acids that are vital to your heart health in general.

As critical as insulin is in your health, leptin may even be more so. Leptin plays a significant role in obesity, heart disease, osteoporosis, autoimmune diseases, inflammatory diseases, and cancer. But there are clues as to how to live a long and healthy life which brings us back to fat and leptin and our need to control it. One can control their insulin production and fat by dietary changes and blood sugar supplements.



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Artichoke Promotes Healthy Fat Digestion and Metabolism
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Date: January 30, 2008 10:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Artichoke Promotes Healthy Fat Digestion and Metabolism

In discussing the health benefits of the artichoke, and the way it promotes healthy fat digestion and metabolism, we are talking here about the true artichoke: the globe artichoke. The alternative Jerusalem artichoke is not an artichoke at all, but a member of the sunflower family. The globe artichoke is a type of thistle.

It is in fact a perennial thistle that originated in the Mediterranean area and is now cultivated world wide. The edible portions are the lower parts of the bracts and the base of the buds, known as the heart while the inedible portion in the center of the bud is known as the ‘choke’. Globe artichokes were introduced to the USA in the 19th century by French and Spanish immigrants who settled in Louisiana and California respectively. Contrary to popular opinion its name did not come from the ‘heart’ and the ‘choke’, but from the Arabic for ground thorn: ‘ardi shauki’.

In today’s world of fast foods, a high consumption of fats and red meat and excessive alcohol consumption, your liver is put under a great strain. Its main function is as a chemical factory, to produce the chemicals, such as enzymes and other proteins, needed to maintain life and also to metabolise the nutrients we need from the food we eat. If you overtax your liver it will not work as it should, which results in poor digestion and assimilation of the nutrients in your food and an increase in the toxins in your blood.

You will feel tired and run down, with digestion problems and many other health complaints. Liver abuse can result in malnutrition, which also results in cirrhosis which is not curable. You should seriously appraise your diet, and identify the eating and drinking habits that are causing the problem, and give your liver a rest. Artichoke extract is a great liver tonic, and your liver will respond well to a break from alcohol and fatty foods, and a course of artichoke leaves and extract.

The main active ingredient of the artichoke is cynarine (1,5-dicaffeylquinic acid), a substance that stimulates the production of bile, and hence renders the artichoke an excellent starter for any meal. This is yet another example of science finding a logical reason for people eating artichokes for centuries in order to promote the health of their liver and digestive system. It is not only for its cynarine content that the globe artichoke is useful, however, but also the luteolin and chlorogenic acids that it contains.

The stimulation of bile production by the cynarine is one the more important of the effects of artichoke on your well being. Bile emulsifies fats and renders them into an easily digested form. Most of the digestive chemicals are water soluble, and without this emulsification of the fat with water then most of the fats we consume would pass through the body unchanged. We would the vats majority of the fat soluble nutrients in our food, including vitamins A, D, E and K.

Bile enables us to digest fats and to absorb vitamins from our food, and also promotes the general health of our digestive system. It is biosynthesized in the liver from various enzymes and triglycerides and then stored in the gall bladder until needed. Its use is prompted by the presence of fats in the system, and this is stimulated by the cynarine in the artichoke leaves.

Its ability to improve bile flow has been recognized by scientist’s world wide, and artichoke juice has been used by the French for many years as a liver tonic. However, it is not just for the liver and the digestive system that artichokes are useful in maintaining good health. They also have an effect on the cholesterol levels in your blood. This is believed to be due to the inhibition of the activity of enzyme HMG CoA Reductase that helps the liver to generate cholesterol. Inhibiting the activity of this enzyme reduces the amount of cholesterol produced.

This can have the effect of reduced the possibility of you developing atherosclerosis, a condition caused by deposition of low density lipid (LDL) cholesterol through the effect of free radical oxidation of the lipid. The less cholesterol to be transported by your blood, then the lower levels of the low density lipid needed to do this. This effect is also possibly due to the fact that bile is formed from cholesterol and triglycerides, and so stimulated bile production would possibly leave less cholesterol in the bloodstream.

Artichoke also possesses antioxidant properties that would contribute even further to this effect by preventing the oxidation of the LDL by free radicals. These free radicals, formed in the body both naturally and by the effects of pollutants such as pesticides, cigarette smoke and traffic fumes, are destroyed by antioxidants. In atherosclerosis the LDL lipids are oxidised and deposited under the surface cells of the blood vessels, and are then digested by certain blood cells forming a hard fatty deposit that can eventually block the arteries affected.

The result can be a heart attack or a stroke, depending on where in the body the blood vessels are affected, and if the cholesterol levels in the body are decreased through it being used to produce bile, then the concentration of LDL lipids used to transport it will also be reduced and the condition will be less likely to occur..

Apart from the liver, the gall bladder is also given a boost by artichoke because that is where bile is stored, and a regular flow to and from the gall bladder maintains its health. The only thing you should be aware of if is that if you are prone to gallstones then the increase in bile flow could cause the stones to be stuck in the bile duct. You should therefore refer to your physician before embarking on a course of artichoke extract if you have a propensity to develop gallstones.

Apart from the phytonutrients already discussed, the globe artichoke also contains a good supply of fiber and minerals such as potassium, iron, calcium and phosphorus, and also some trace elements that your body needs. It is therefore more than just a bile stimulant, but provides a wide range off essential nutrition to your body. It is know to aid conditions such as gout, high blood sugar, and digestive complaints such as flatulence, bloating and abdominal cramps.

Apart from cooking and eating the tender parts of the leaves, or bracts, you can make an infusion of the parts that you don’t eat. Chop up the tougher leaves and pour boiling water over them as if making tea. Leave it to infuse for a few minutes and then drink. Honey can be used to take away the bitter taste; honey rather than sugar due to its greater nutritional content.



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Join The Age Specific Probiotic Revolution For Better Health
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Date: January 18, 2008 10:54 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Join The Age Specific Probiotic Revolution For Better Health

Probiotics are good or friendly bacteria that may just be the most important supplement of all. Probiotics may help boost your immunity, heal disease, and according to recent research, help prevents cancer. All of the above especially applies to both babies and vulnerable older adults. Along with helping people to maintain healthy populations of beneficial bacteria, probiotics have many other health benefits. One that has recently become known is the ability to protect against colon cancer.

A recent study in Ireland found that probiotics, which are live bacteria that can benefit health, may also be just as important as vegetables, legumes, whole grains, and regular exercise in our strategies to lower the risk of cancer. This study was performed on eighty patients who had had either colon cancer tumors or polyps recently removed. Each patient received either a probiotic or a placebo. Included in the probiotic was Lactobacillus rhamnosus and a Bifidobacteria that was combined with other probiotics. These formulas which contain live probiotics and prebiotics are known as synbiotics. After three months of use, the balance of colon bacteria in those receiving the symbiotic formula had changed to having more lactobacilli and Bifidobacteria and less of the bacteria that is linked with increasing cancer risk, as compared to those patients who received placebos.

Additionally, those patients who received synbiotics showed a decrease in DNA damage in the lining of the colon along with a decreased growth and reproduction of colon cells. Also, neither of the groups reported any adverse effects of the synbiotics. These findings were also consistent with those of earlier studies, concluding that “bad” bacteria can produce substances that promote the development of colon cancer. Probiotics have also been shown to decrease abnormal colon cell development and DNA damage in animals.

However, these findings are not yet enough for the FDA to allow the claims that probiotics work against colon cancer, but rather simply state that they support colon health. These studies certainly suggest that the right beneficial strains in the right amounts of probiotics in your gut are a great amount better for you than too much of the bad bacteria.

Many people take a lifetime approach to probiotics, believing that they are appropriate for people of all ages, from babies to children to adults. Probiotics have an immunomodulatory effect at any age by stimulating and boosting the immune system. Even for infants, probiotics are critical. It has been shown that mothers who take a probiotic blend during pregnancy have babies who are less prone to eczema and other allergic conditions.

Additionally, the advent of new methods has made it possible to characterize the gut microbiota changes as we age, and in health and disease. Because of this, products that target specific issues and ages have been produced which can work with each individual’s needs. The two key bacteria helping advanced adults are Lactobacillus rhamnosus and Bifidobacteria, as they provide the additional bacterial strains that are associated with the older adult’s needs. Additionally, newborns and babies do not need the same composition as adults. Instead, products for babies include B. infantis, B. bifidum, and B. breve. The greatest thing about probiotics is that you can’t overdose. Probiotics are always quite safe and very effective.

When buying a probiotic supplement, look to your local health food store to find the freshest name brand probiotic because not all probiotics are made the same.



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Eggs: An Excellent Source of Omega-3 Oils for Better Health
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Date: December 18, 2007 11:43 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Eggs: An Excellent Source of Omega-3 Oils for Better Health

Eggs have many health benefits, among them being the fact they can be an excellent source of omega-3 oils that can promote better health in those that take it as a supplement. Hens fed on flax seeds are particularly high in omega-3 fatty acids, although eggs have many health benefits other than omega-3.

Most of the health benefits of Omega fatty acids are well known, although many more are being continually discovered as scientists research the uses to which the substances can be put in our bodies. Omega-3 fatty acids have long carbon chains that are polyunsaturated, i.e. contain multiple double bonds in the hydrocarbon chain. As opposed to saturated fatty acids with no double bonds. They are important components of our neurological systems and help to build up cell membranes, but are probably best known for their effect in protecting us from cardiovascular diseases. Omega-3 fatty acids can help us to maintain a healthy heart, and so enable us to live longer.

The current western diet has been changing to reduce cholesterol intake and improve our lifestyle. However, this has not all been well advised, and the resultant diet is rich in vegetable oils as opposite to animal fats, the relative levels of omega fatty acids having changed in favor of omega-6 fatty acids. These omega-6 fats are not as healthy for us as omega-3, and can lead to a thrombogenic state that more easily leads to cardiovascular diseases and blood clots. Rather than a normal omega-6 to omega-3 ratio of around 2:1, this ‘improved’ diet has increased it to anything up to 50:1.

The American Heart Association has been advocating a diet richer in omega-3 fatty acids since 1996, yet while research continues to favor omega-3, the increase in consumption of vegetable oils has continued to increase, and with it a reduction in the overall health of a nation.

Omega-3 enriched eggs have been introduced as one means of redressing the balance. Hens fed on flax seeds lay eggs with a much higher proportion of omega-3 fatty acids than normal: up to and over 150mg per egg. Such eggs also have reduced cholesterol – over 15% less, and also are higher in vitamin E, a strong antioxidant, by up to 300%.

Two of the components of omega-3 oils, linoleic acid and linolenic acid, are what are known as ‘essential’ fatty acids. The term means that they cannot be manufactured in your body, so must essentially be introduced through your diet. When the human body developed to what it is now, the consumption of fish and other oils rich in omega-3 fatty acids was a significant part of our diets, and allowed our bodies to develop the biochemistry and metabolism that it uses today.

If we now upset that biochemistry by cutting our intake of unsaturated fatty acids, our metabolism will suffer and our general health decline. This is one reason why humans should interfere with their natural eating habits as little as possible, or if we do so excessively we should use supplements to replace what we are excluding from diets that have been natural to us for countless millennia. It is dangerous now for the human race to suddenly switch to a significantly different diet without suitable supplementation, because we do not know the long terms effects of doing so.

One way to maintain a steady intake of the fatty acids our metabolism needs in order to ensure our survival is to eat eggs, and especially omega-3 enriched eggs. Of course, eggs have a lot more beneficial health effects than just omega-3. Take choline for example. This is a trimethylated compound that is important in the metabolism of fats. It is the newest official B vitamin, and is an essential component of cell membranes. It is particularly important for the maintenance of the health of your brain, and preventing many brain disorders.

It is also important in methylation, an important biochemical process, and also in the biochemical synthesis of the neurotransmitter acetylcholine. This substance is used to pass messages between nerve cells and from nerve cells to muscles, and a deficiency can cause many health problems, including heart disease and diseases of the vascular system. Methylation is a very important biochemical reaction, being used particularly in messages between body cells and is used to switch genes on and off.

Up to 90% of Americans are deficient in choline, and subject to many diseases because of it. Symptoms include insomnia, fatigue, excess fat concentrations in the blood and problems with your nerves and muscular control. It can cause liver problems and heart problems, and cause a number of brain disorders.

Choline is available in the diet from lecithin and egg yolks, and also soya beans, flax seeds, peanuts and potatoes. The typical American diet is not conducive to an adequate choline intake, and increased egg consumption can help to redress this. This is particularly true of eggs from hens fed with flax seeds, or linseed, from which the triple benefits of choline, omega-3 fatty acids and vitamin E are obtained. Just two eggs will provide you with almost 50% of your daily requirement of choline.

Some are wary about the cholesterol content of eggs, but studies have indicated that it not so much the amount of dietary cholesterol that is eaten, but saturated fats that cause the excess deposition of cholesterol in the arteries. Cholesterol is an essential part of human biochemistry, and without any we could not survive. In fact, studies have shown that eating two eggs daily can improve your cholesterol levels

Eggs are also rich in lutein, and contain more than vegetables such as spinach. Lutein is an important carotenoid that is believed to prevent age related macular degeneration, which can lead to blindness, and also prevents the development of cataracts. Eggs also appear to have anti-clotting properties on the blood, and so help to reduce the thrombogenesis of omega-6 fatty acids.

Without a doubt, eating eggs is very good for your health, and especially so if they are rich is omega-3 fatty acids. They contain a wide variety of nutrients and truly are a complete food packaged by nature. Some may prefer to stay away from eggs and miss the omega-3 benefits so there is an alternative for diets that exclude eggs. Omega-3 is available in a supplement form that one can take on a daily basis to reap the benefits omega-3 presents.



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Loose Weight By Cutting Dietary Fat Absorption
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Date: December 08, 2007 06:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Loose Weight By Cutting Dietary Fat Absorption

You can lose weight by cutting dietary fat absorption, although in order to understand the need for this you have to appreciate the effect that fat has on your weight. Not only fat, but any form of calories.

The word ‘calorie’ appears to have a bad press, and there have been a lot of ill informed comments made about calories and whether calorie controlled diets are effective or not. Quite frankly, it is all said in ignorance. Whether you agree or not, the calorie is a measurement of energy and the calorie content of foods is what is calculated to be the energy value of these foods.

Once inside your body, that energy is either used up or converted to body mass. It is not necessarily converted to fat, since that extra weight could be in the form of muscle tissue. However, it is converted to body mass and so you can put on weight. The basic equation is that if you take in more energy than you use, then you add weight, and if you use more energy than you take in, then you lose weight. It is slightly more complex than that, but it is basically true.

That does not mean that if you eat a pound of dripping (the fat that drips off cooking meat) you will add a pound of weight. It is the calorific value of the dripping in terms of energy, whether measured in calories or in joules, that is the relevant factor, and if that is 4000 calories, which is about average for various types of dripping, then if you use up 4001 calories in exercise, you can safely spread your pound of lard on toast and eat it without putting on weight (you will have also to use up the calories in the toast).

It is the calorie equation that is important, and if this is negative then you will lose weight. You have to: it is a law of science! Whether your calories are in the form of cookies, candies, avocados (loads of them) or dripping, it is all the same. A meat calorie is the same as a vegetarian or vegan calorie. If you eat more than you use you put on weight.

Different foods contain different quantities of energy, or calories. If you buy a Big Mac you eat 570 calories, and 5 from your Super Pepsi. If the guy next to you has an English Muffin, he will have 140 calories. However, if he then goes home and slouches on the sofa watching TV and you go to the gym for a serious workout, he is liable to put on weight and you lose it. It’s all in the equation!

However, you don’t just use calories in exercise. Your metabolism is also important. In fact 65% - 75% of the calories you use in a day are used up by the body at rest: the metabolism that takes place 24/7 to keep you alive. The heartbeat, breathing and brain activity for example, all use up energy. So not all is doom and gloom, and you can burn up these calories even while you are sleeping.

However, there is another way to prevent the fat you eat from turning into weight. (Incidentally, if you exercise a lot, that weight will likely be in muscle mass, but if not then it will certainly be fat). You have a clue to the way that can be done in the first sentence of this article: ‘dietary fat absorption’.

If the fat is not absorbed into the body, then it is not available to be metabolized into body fat. It will pass through the body unchanged. It is not the fat you consume that makes you gain weight, but the amount of that fat absorbed through your intestines. But how is it possible to selectively prevent the fat in your diet from being emulsified by the bile and absorbed through the intestinal wall?

By means of chitosan. This is a fiber that absorbs part of the fat from the food you have eaten and hides it away from your digestive system. It cannot be broken down into sugars and then into fat to add to your unwanted weight. However, because it works after your meal, you get to eat what you want – that ‘finger lickin’ good’ stuff you love, but don’t suffer the consequences of failing to exercise to work it off. It’s like you just ate lettuce without the fried chicken with the crispy fatty skin.

So what is this miracle substance, chitosan? Biologists would recognize the name as being associated with chitin, the acetyl-glucosamine polymer that forms the carapaces, or shells, of crabs, lobsters and other marine shellfish. Chitosan is formed by deacetylating the chitin and is mainly used to enhance the growth of plants, and also as a filtration aid. So what does it do to help to remove some of the fat from your diet after you have eaten it?

The mechanism by which it does this is not fully understood, and in fact is still disputed in some quarters. However, the proof of the pudding is in the eating and it appears to act according to the claims. There are two possible mechanisms, one of which is connected with the deacetylation of the chitin molecule. Because of this, the resultant chitosan molecule has cationic groups on the polymer chain. Cations are positively charged, and can react with acids, not the least of which are the bile acids that break down lipids (fats) to render them into a form suitable for absorption.

It is possible for the chitosan to react with the bile acids and prevent them from breaking down the fats into a condition that enables them to be passed through the intestinal wall. However, it has also been proposed that dietary fibers work by increasing the thickness of the boundary layer of the intestine through which the fats would have to pass. This would have the effect of reducing the lipid uptake.

It is also possible that since chitosan is a fibrous substance, it attracts the fats through its charge and absorbs them into a swelling ball of fats and fiber that is not only impermeable by the bile acids, but also passes through the intestinal tract unchanged and eventually excreted. In fact, there is not proof for any of these projected mechanisms, and all are theoretically possible. The fact is that it appears to work, but must be taken for several weeks for the effects to be noticeable.

It is possible to lose weight by dietary fat absorption, and whatever mechanism is used by chitosan, it is well worth trying if you like your fatty foods but also want to lose weight. Combine chitosan with a good exercise regime and you might find that you can control your weight whatever you eat. Chitosan is available over the counter at any health food store.



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Regulating Blood Pressure Naturally
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Date: March 28, 2007 10:29 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Regulating Blood Pressure Naturally

Regulating Blood Pressure Naturally

 

High blood pressure (also known as hypertension) affects about 65 million Americans, or about 1 in 3 adults. There are many potential causes of hypertension, but not necessarily any symptoms. In fact, 30% of the people who have high blood pressure don’t even realize it.

In other words, just because you don’t have symptoms doesn’t mean you don’t have high blood pressure. That’s why it’s called “The Silent Killer.” And, make no mistake about it: high blood pressure is dangerous. It is the number one modifiable cause of stroke. Just lowering blood pressure reduces the chance of stroke by 35 to 40 percent. Other conditions, including heart attack and heart failure can be reduced from 25 to 50 percent, respectively.

In this issue of Ask the Doctor, we’re going to talk about high blood pressure and an exciting natural treatment for lowering blood pressure safely and effectively.

Of course, changing blood pressure numbers depends, in a large part, on the choices we make every day – how much we exercise, the foods we eat, and our lifestyle overall. But, for those times we need extra help, there is a new, scientifically-studied supplement to help us along our path to better health and lower blood pressure.

 

Blood pressure guidelines from the National Heart, Lung, and Blood Institute.

Category

Systolic (mm/Hg)

Diastolic (mm/Hg)

Result

Normal

Less than 120

And Less than 80

Excellent!

Prehypertension

120-139

Or 80-89

Make changes in eating and drinking habits, get more exercise and lose any extra pounds.

Hypertension

140 or higher

Or 90 or higher

You have high blood pressure. Talk to your healthcare professional on how to control it.

 

Q. What exactly is blood pressure?

A. Blood pressure is divided into two parts, systolic and diastolic. Systolic is the pressure of the heart beating. Diastolic is the pressure of the heart and vessels filling. When blood pressure numbers are written out, like “120/80,” 120 is the systolic pressure and 80 is the diastolic pressure. The unit of measurement for blood pressure is millimeters of mercury, written as “mm/Hg.”

 

Q. What is considered high blood pressure?

A. A person’s blood pressure can naturally vary throughout the day – even between heartbeats.

However, if the numbers are consistently high (over 120 systolic and 80 diastolic), after multiple visits to your healthcare practitioner, you may have either pre-hypertension or high blood pressure.

Young arteries and arteries that are kept young through healthy diet and exercise are typically more elastic and unclogged. Blood flows through them easily and without much effort. However, as we age, our arteries become more prone to plaque buildup (due to diets high in saturated fat and sedentary lifestyles) and don’t “flex” as well under pressure. The result is faster blood flow, all the time. Over the long term, it damages heart tissue, arteries, kidney and other major organs.

To get a better idea of high blood pressure, compare your arteries to a garden hose. When unblocked, a garden hose allows water to flow through it quickly and easily – without any real rush or stress. However, if you block the end of the hose with your thumb, closing it off even a little, water rushes out much more quickly.

For many years, high diastolic pressure was considered even more of a threat than high systolic pressure. That thinking has changed somewhat but high diastolic numbers could still mean organ damage in your body – especially for individuals under 50.

 

Q. What courses high blood pressure?

A. The reasons for hypertension aren’t always clear. However, there are lifestyle factors that contribute to high blood pressure that you can change:

 

Body type: Weight isn’t always a reliable indicator of whether or not you’ll have high blood pressure – but the type of weight is. Lean body mass – muscle – doesn’t increase blood pressure levels the way that fat can. However, fat body mass, especially fat around your middle, can contribute to high blood pressure.

 

Sedentary lifestyle: Too often, many of us sit down all day at work, and then sit down all night at home. Over time, this inactivity usually leads to weight gain, making the heart work harder to pump blood through the body. In a way, it almost seems contradictory, but inactivity usually leads to higher heart rates.

 

Sodium intake: Sometimes it’s hard to believe how much salt there is in processed foods. However, salt intake in itself is not necessarily bad. For people with a history of congestive heart failure, ischemia, and high blood pressure, sodium is definitely out. For those individuals, it leads to more water retention, which increases blood pressure. (Salt’s effect on water retention is one reason that so many sports drinks have fairly high sodium content – the sodium in the drink prevents your body from sweating out too much water.) But, for healthy individuals, moderate salt intake, especially a mixed mineral salt like sea salt or Celtic salt (good salt should never be white) is fine.

 

Low potassium intake: Unlike sodium, potassium is a mineral which most Americans get too little of. Potassium helps regulate the amount of sodium in our cells, expelling excess amounts through the kidneys. Low levels of this mineral can allow too much sodium to build up in the body.

 

Heavy alcohol intake: Having three or more alcoholic drinks a day (two or more for women) nearly doubles an individual’s chance of developing high blood pressure. Over time, heavy drinking puts a lot of stress on the organs, including the heart, liver, pancreas and brain.

 

Unhealthy eating: Eating a lot of processed or fatty foods contributes to high blood pressure. Adapting a diet that is rich in fruits and vegetables, whole grain products, fish, nuts and magnesium and potassium (like the Dietary Approaches to Stop Hypertension, known as the “DASH” diet) can bring it back down.

 

Smoking: If you smoke, stop. Smoking damages the heart and arteries – period. Nicotine constricts blood vessels, increases heart rate, and raises blood pressure. This in turn, increases hormone production and adrenaline levels, further stressing the body.

 

As if that weren’t bad enough, the carbon monoxide in cigarette smoke replaces the oxygen in the blood, making the heart work even harder to make up the difference. Since the effect of a single cigarette can last for an hour, smoking throughout the day leads to continuously revved-up blood pressure.

 

Some of these factors might sound like a lot to overcome. The important thing to remember is that all of these behaviors are changeable. If you have high blood pressure, modifying any of these can significantly lower blood pressure as part of an overall plan.

 

Q. What are the blood pressure numbers I should see?

A. Experts consider healthy blood pressure numbers to be 115/75 mm/Hg. The reason? They found that the risk of cardiovascular disease doubles at each increment of 20/10 mmHg over 115/75 mm/Hg. Even small jumps in blood pressure numbers increase the risk of stroke and heart attack.

 

Q. Okay, so other than diet, exercise and lifestyle changes are there other natural ways or supplements I can use to lower my blood pressure?

A. Yes, in fact, you hear about some of them in the news all the time – fish oil, CoQ10, and garlic. As effective as these symptoms are, they typically lower systolic pressure much more than diastolic pressure.

However, there is a blend of scientifically and clinically studied natural ingredients that lower high blood pressure separately, and work even better when they’re combined. This combination blend contains: dandelion leaf extract, lycopene, stevia extract, olive leaf extract and hawthorn extract.

Every one of these ingredients has been studied and recommended for years. But now, a scientific study on a supplement that combines them in one synergistic formula shows encouraging results for lowering systolic and diastolic blood pressure.

Let’s take a look at each:

Stevia leaf extract

Supports healthy blood pressure levels according to clinical studies.

Hawthorn extract

Supports the heart and balance sodium and fluid levels.

Olive leaf extract

Scientifically shown to support healthy blood pressure.

Dandelion leaf

Helps reduce fluid retention

Lycopene

Clinically shown to support arteries, circulation and heart health.

 

Stevia:

Stevia (Stevia rebaudiana) originated in South America, and is often used as a sweetener. Glycosides in stevia, particularly stevoside, give the plan its sweet flavor 0 anywhere from 100 to 200 times sweeter than sugar.

The leaf of stevia is considered the medicinal part of the plant. Research shows that extracts of the leaf relax arteries and help prevent the buildup of calcium on artery walls – keeping them healthy and reducing blood pressure.

In a long-term, randomized, placebo-controlled clinical study, stevia reduced systolic and diastolic blood pressure. On average, participants’ blood pressure reduced from baseline 150 mm/Hg to 140 mm/Hg systolic and 95 mm/Hg to 89 mm/Hg diastolic.

And, in another double-blind, placebo-controlled clinical study, stevia lowered blood pressure quite significantly – by an average of 14 millimeters of mercury in both systolic and diastolic readings. Those are impressive numbers!

Despite its role as a sweetener, stevia may have a side benefit to for those with hypertension – blood sugar regulation. Scientific studies show that extracts of stevia regulated blood sugar and reduced blood pressure.

A clinical study showed that stevia extract actually improved glucose tolerance by decreasing plasma glucose levels during the test and after overnight fasting in all participants. Regulating blood sugar is very important for those with high blood pressure. When blood sugar levels are high, blood vessels are inflamed. Many people with diabetes have high blood pressure as well. In a paired, cross-over clinical study, stevioside (one of the compounds in stevia) reduced glucose levels in individuals with type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. It shows great potential in treating type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. Its shows great potential in treating type 2 diabetes as well as hypertension.

 

Hawthorn extract:

Hawthorn (Crataegus spp. Oxycantha) has been used since ancient ties as a medicinal herb – even being mentioned by the Greek herbalist Dioscorides, in the first century AD. Traditionally, it has generally been used for support of the heart. Modern research points to bioflavonoid-like complexes in hawthorn leaf and flower that seem to be most responsible for its benefits on cardiac health, like blood vessel elasticity.

The bioflavonoids found in hawthorn include oligomeric procyanidins, vitexin, quercetin, and hyperoside. They have numerous benefits on the cardiovascular system. Hawthorn can improve coronary artery blood flow and the contractions of the heart muscle. Scientific studies show that the procyanidins in hawthorn are responsible for its ability to make the aorta and other blood vessels more flexible and relaxed, so that blood pumps more slowly and with less effort – sparing the cardiovascular system such a hard workout.

The procyanidins in hawthorn also have antioxidant properties – protecting against free radical cellular damage.

And, hawthorn may also inhibit angiotensin-converting enzyme. Angiotensin-converting enzyme is responsible for retaining sodium and water, and may have roots in our evolutionary development. It influences blood vessel contraction and dilation, sodium and water balance and heart cell development – just about everything that has to do with blood pressure. This may have developed as a way of dealing with periods of drought and stress. By narrowing the blood vessels, the body could guarantee an adequate supply of blood and focus on repairing tissue.

Unfortunately, that can lead to real problems these days. Since many of us live in an industrialized society, and frequently have pretty sedentary lifestyles, conserving sodium just makes the conditions for high blood pressure that much worse.

Like the other ingredients in this combination, hawthorn showed benefits on other body systems, too. In clinical and scientific studies, it not only lowered blood pressure, but also showed anti-anxiety properties and regulated blood sugar.

 

Olive leaf extract:

Olive leaf (Olea europaea) comes up again and again in scientific and clinical studies as having beneficial effects on hypertension. One of olive leaf’s most beneficial compounds is oleuropein – the same compound that makes olive oil so helpful in reducing blood pressure. Here again, we have to look at the traditional Mediterranean diet, which features voluminous use of olives and olive oil. Not surprisingly, blood pressure is generally much lower in Greek and Italian populations.

But it’s not just the diet – scientific studies showed that oleuropein lowered blood pressure by relaxing the blood vessels and prevented buildup of plaque in arteries. Plus, whether in olive leaf extract or in olive oil, oleuropein works as an antioxidant, too.

 

Dandelion leaf extract:

Dandelion (Taraxacum offinale) leaves provide a healthy supply of vitamins, much like spinach. In fact, although it has become the bane of North American gardeners and lawn owners, dandelion greens are a component of many gourmet salads.

Medicinally, dandelion has been used for centuries, dating back to ancient Greece. Leaves intended for medicinal use are harvested before flowering, to ensure the most nutrients.

They are a very rich source of vitamin A, and contain vitamin D, vitamin C, carious B vitamins, iron, silicon, magnesium, zinc and manganese, too. Dandelion leaves produce a diuretic effect in the body, similar to a prescription drug. Since one of dandelion leaf’s traditional uses was the treatment of water retention, it’s really not too surprising. Dandelion leaf is also rich in potassium – one of the vital minerals many Americans lack in their diet. So, even though it may act as a diuretic, it replaces more potassium than the body expels.

The diuretic effect of dandelion can relieve hypertension by drawing excess water and sodium from the body and releasing it through the kidneys as urine. Getting rid of extra water and sodium allows the blood vessels to relax – lowering blood pressure.

 

Lycopene:

If a nutrient can be called exciting, lycopene is it. Lycopene is found mostly in tomatoes and processed tomato products, like pasta and pizza sauce. Related to beta-carotene lycopene shows great antioxidant abilities among its many talents. In fact, it shows even greater free-radical scavenging properties than beta-carotene, its more famous cousin. Healthy intakes of lycopene can guard against a variety of chronic conditions, including lowering LDL (bad) cholesterol, lowering homocysteine levels and reducing blood platelet stickiness that can lead to clogged arteries. It’s even being studied for its protective effect against prostate cancer.

And, for proof, you don’t have to look too far to see the amazing effect lycopene intake can have on health. The Mediterranean diet provides an excellent example. Its high intakes of vegetables, (tomatoes, of course, playing a central role) fish, and whole grains improve cholesterol levels and lower blood pressure. The research on lycopene as a stand-alone nutrient has been compelling. A randomized clinical trial found that not having enough lycopene was associated with early thickening of the arteries.

So, it makes sense that other clinical trials, showed that higher intakes of lycopene frequently meant less thickening of arteries, and a reduced risk of heart attack. In one study, the risk of heart attack was 60% lower in individuals with the highest levels of lycopene. In a multicenter study, similar results were found – men with the highest levels of lycopene had a 48% lower risk of heart attack.

 

Q. What can I expect taking this herbal combination?

A. You should notice both systolic and diastolic numbers lowering in about two weeks. The scientific study showed that for pre-hypertensive and stage I, (early hypertensive individuals) this combination for ingredients lowers both systolic and diastolic blood pressure.

When you’re taking herbs to support your blood pressure, it’s important to keep it monitored so you have an accurate reading (and record) of your numbers. If you need to, you can pick up a home blood pressure monitoring device. These can retail for anywhere from $30 all the way up to $200, but buying one in the $30 to $50 range is a good idea and money well spent. Consider taking the machine to your local doctor’s office or fire department to have it tested for accuracy against a professional blood pressure monitor. See the chart below for tips on getting an accurate reading from a home monitor.

 

Tips for Accurate Blood Pressure Monitoring:

-Relax for about 5 to 10 minutes before measurement.

-If you have just come inside from cold outdoors allow yourself to warm up.

-Remove tight-fitting clothing and jewelry.

-Unless your physician recommends otherwise, use left arm to measure pressure.

-Sit, don’t stand.

-Remain still and do not talk while using the monitor.

 

Q. Are there any side effects?

A. There were no side effects noted in the study. However, because of the mild diuretic effect of dandelion leaf extract, you may notice an increase in trips to the bathroom. It’s always important to make sure you don’t get dehydrated, so you may want to drink more water during the day.

 

Conclusion:

High blood pressure doesn’t happen overnight. As we get older, the likelihood of developing hypertension increases. And, stressful, fast-forward lifestyles, bad diets and no exercise conspire to raise our blood pressure.

 

In my own practice I have helped patients move toward a healthier lifestyle, including diet, exercise, and blood-pressure reducing supplements. They live better, more vibrant lives as a result, and their blood pressure normalizes. It really can happen – you can bring your blood pressure back to normal, and this combination of scientifically and clinically validated ingredients can help.



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For Better Heart Health ...
TopPreviousNext

Date: February 06, 2007 12:57 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: For Better Heart Health ...

Nutrients Every Heart Needs

 

High blood pressure. High cholesterol levels. Ever increasing stress. All are factors related to the development of heart disease – the leading cause of death for both men and women. In fact, 1 in 2 women in the United States die of heart disease or stroke, while 1 in 30 dies of breast cancer. If current trends remain unchanged, not only will heart disease remain the primary killer in our country, the number of people it claims will steadily and dramatically increase in the next 20 years.

 

Fortunately, heart disease is a problem you can do something about. Proven ways to prevent or mitigate the effects of heart disease include taking targeted nutritional supplements, making changes in the foods we eat, exercising most days of the week, drinking in moderation, eliminating tobacco use and adapting a positive attitude. Research shows that those of us who are often angry and depressed have more heart disease than people that live their lives with a more positive outlook.

 

In this Ask the Doctor, we’ll talk about specific nutritional supplements that are heart healthy, whether your goal is to prevent heart disease or reduce the effects of heart disease if you currently have it.

 

Q. I am trying hard to live a healthier life. But it all seems so overwhelming. How do I start?

A. It may help to know that you’re not alone in feeling overwhelmed. Lots of people feel this way. This is why the Centers for Disease Control and the American Heart Association are both urging people to prevent heart disease by identifying their individual health risk factors.

 

A risk factor is an indicator of whether or not you may develop a certain health condition. In heart disease prevention, there are two kinds of risk factors. There are risk factor you can control – such as diet, exercise, and the supplements you take. There are also risk factors you can’t change or control –your age, race, and gender, as well as your family’s history of heart disease.

 

Examples can be really helpful. Let’s follow three adults – Fred, Jane, and Earl – and determine their risk factors.

 

Low Risk

Fred is 32, single, has a job he loves, has an optimistic attitude about his life, and works out 5 days a week. Most days Fred’s diet is fruits, vegetables, whole grains and low fat. Occasionally Fred will eat a cheeseburger and fries when he watches the game with his buddies. Fred’s risk factors are his male gender and the occasional high fat content in his diet.

 

Moderate Risk

Jane is 55, a lawyer, married, and has a very stressful job. Jane eats lots of salads, fruits, and whole grains. However, her job requires her to work long hours which leaves little time to exercise. Jane is for the most part happy with her life, but her work stress had led to times of negativity. Her father had a heart attack when he was 56. Jane’s risk factors include her age (greater than 50), negativity from job stress, lack of regular exercise, and a family history of heart disease.

 

High Risk

Earl is 65, married, and has just retired from a job he hated. He spends most of his day watching TV and eating potato chips and other high fat, salty snacks. Earl has told his friends and family since he worked so hard for so long, he is sure to drop dead soon after retiring. He has high cholesterol and high blood pressure. Earl’s father had a heart attack and died when he was 73. Earl’s risk is his male gender, age (greater than 50), sedentary lifestyle, poor diet, negative outlook on life, high cholesterol and high blood pressure, and a family history of heart disease.

 

Q. OK, it’s pretty easy to see that Fred needs to watch his diet, Jane needs to exercise more, and Earl needs lots of help. But, which supplements should they take?

A. The Whole Heart Nutrition chart is an easy way to determine the supplements each risk level needs. As you can see, everyone wanting to prevent heart disease – Fred, Jane, Earl, you, and I – need to take quality heart formula multivitamin, garlic, and a fish oil supplement providing Omega-3 fatty acids. CoQ10 is also a smart choice for complete heart heath support.

 

Q. Why do we all need to take a “heart multivitamin”? Why can’t we take a regular multivitamin to prevent heart disease?

A. Since the human heart simply cannot function without adequate amounts of certain vitamins and minerals, it seems logical that a multivitamin would be the foundation of good nutrition for your heart. Heart-health formulated multivitamins provide the exact nutrients needed to prevent heart disease.

 

That’s why we need to take a specially formulated heart-focused multi-vitamin. The cells and the tissues that make up the heart must have vitamins C, A, and E, as well as B1, B6, and B12 to function. Folic acid, the little B vitamin that is so crucial in preventing spina bifida (a birth defect), breast cancer, and Alzheimer’s disease is also needed to keep heart muscles strong. The B vitamins and folic acid are very important to heart health because they help lower homocysteine levels. Homocysteine is a potential and emerging cardiac risk factor,

 

Magnesium is a mighty mineral and healthy hearts need it every day. Aloha lipoic acid, a fatty acid, provides protection against heart cholesterol and high blood pressure. Lutein and lycopene are all-natural nutrients and keep our arteries free from the buildup of plaque, a condition linked to heart attacks and strokes.

 

Multivitamins formulated with these exact vitamins, minerals, and nutrients will work with medications often prescribed to treat heart disease and provide the nutrition our hearts need.

 

Q. Don’t all multivitamins work with medications prescribed to treat heart disease?

A. Many multivitamin formulas contain herbs and other nutrients that can interfere with prescription medications, especially mediations prescribed to treat heart disease. One multivitamin does not fit all.

The more risk factors you have, the greater your chance of developing heart disease.

Factors you CAN’T change

 

Increasing age

About four out of five people who die of coronary heart disease are 65 or older.

Male gender

Men have more heart attacks than women. Even after menopause, when women’s death rate from heart disease increases, men continue to have more heart attacks until both groups reach their 80s.

Heredity (including Race)

While heart disease has often been noted to occur in families, recent research has shown this link may be the result of environment more than heredity. In other words, your dad’s high blood pressure and your high blood pressure may be related more to your mutual love of salty foods than your genetics. African Americans tend to have very high blood pressure and a higher risk of heart attacks than other races.

Factors you CAN change

 

Tobacco smoke

Smokers have twice the risk of heart attack than nonsmokers.

High blood cholesterol

As blood cholesterol rises, so does the risk of heart disease.

High blood pressure

High blood pressure increases the heart’s workload, causing the heart to thicken and become stiffer.

Physical inactivity

Exercise most days of the week helps prevent heart disease. The more vigorous the activity, the greater your benefits.

Obesity and overweight

People who have excess body fat are more likely to develop heart disease and stroke even if they have no other risk factors.

Individual coping styles

Research has shown there is al ink between heart disease risk and stress, happiness, negativity, and socioeconomic status.

Alcohol consumption

Drinking too much alcohol can raise blood pressure. However, the risk of heart disease in people who drink moderate amounts of alcohol (an average of one drink for women or two drinks for men per day) is lower than in nondrinkers.

 

Q. What can garlic supplements do for Fred, Jane and Earl or other people with low to high risk factors?

A. Garlic supplements have a very long and very successful history of preventing premature death from heart attacks. Lately, however, there have been some conflicting news stories about supplemental garlic’s ability to lower high cholesterol and high blood pressure – the causes of heart disease and death. That’s because many different garlic supplements have been used in these studies – garlic oil, garlic powder, aged garlic extract, and supplements made from fresh garlic. They have all been studied clinically for their effects in heart disease.

 

The best garlic supplements (and the ones that showed the best effects in garlic studies) contain alliin, which is then converted to allicin. Allicin is the compound that lowers harmfully high cholesterol levels and dangerous blood pressure readings. Allicin is also responsible for garlic’s characteristic odor. Because alliin is very stable when dry, properly prepared and enteric coated fresh garlic preparations preserve the allicin-producing action until the garlic mixes with the fluids of the intestinal tract. Fresh garlic extract’s enteric coating also prevents garlic breath. In contrast, aged garlic contains absolutely no allicin or allicin potential. This fact is probably responsible for the poor results noted in lowering cholesterol and blood pressure from aged garlic preparations.

 

The most effective garlic supplements are made from fresh garlic, enteric coated, and provide a daily dose of at least 10 milligrams (mg) alliin or a total allicin potential of 4,000 micrograms (mcg). Taking a once-daily garlic supplement that delivers 4,000 mcg of allicin will lower Jane’s and Earl’s high blood pressure and Earl’s high cholesterol, naturally and effectively.

 

Whole Heart Nutrition

Supplement

Low Risk

Moderate Risk

High Risk

Heart multivitamin

Every day

Every day

Every day

Garlic supplement 4,000 mcg allicin

1 tablet each day

1 tablet each day

1 tablet each day

Fish oil supplement with omega-3 fatty acids

600 mg each day

1200 mg each day

1800 mg each day

CoQ10

60 mg

100-200 mg each day

200-400 mg each day

Each additional risk factor requires additional supplements or increased doses for protection from heart disease.

 

Q. What about fish oil supplements? I know they can prevent heart disease but I’ve also heard they contain harmful substances, too.

A. You’re right on both counts. But, there are excellent fish oil supplements naturally loaded with Omega-3 fatty acids, powerful nutrients that prevent heart disease, that are also certified free of harmful contaminants.

 

In the 1980s, researchers first began noticing the native Inuit (Eskimo) populations of Greenland and Alaska had hardly and heart disease despite a very high-fat diet. The deep-water fish that these peoples eat (and continue to eat to this day) are indeed quite fatty. But, this kind of fat, rich in Omega-3 fatty acids actually protects the heart instead of harming it.

 

Research has shown that the Omega-3 fatty acids in fish oil supplements can:

-Reduce the risk of arrhythmias, lethal heartbeat rhythms that cause sudden death.

-Lower the levels of triglycerides, fats in the blood that can increase a person’s

risk of dying from a heart attack, even if a person’s cholesterol levels are normal.

-Slow atherosclerosis – the growth of harmful plaque on artery walls.

Atherosclerosis develops over many years. If the plaque growth is slow and

stable, chances are low that a heart attack will result. However, rapidly growing

or unstable plaques can rupture. The body responds with inflammation, which

causes blood clots to form. These blood clots block the artery and cause a heart

attack.

-Keep blood pressure levels low. Many people have high blood pressure for years

without knowing it. That’s because it has no symptoms. Uncontrolled high

blood pressure can lead to stroke, heart attack, heart failure, and kidney failure.

While 25% of Americans have high blood pressure, nearly one-third of these

people don’t know they have it. This is why high blood pressure is often called

the “silent killer.”

 

You can get all of this heart disease preventive protection from just 600-1800 mg of fish oil. It’s pretty simple to see why Fred, Jane, Earl, and you and I need to take fish oil supplements every day.

 

However, it is absolutely critical that the fish oil supplement you take is free of contaminants and guaranteed fresh! Make sure that the manufacturer of the fish oil supplement you buy is able to provide documentation of purity in their product. Supplements should contain no detectable dioxin (a widely used toxic preservative), DDT (a toxic insecticide), PCBs (polychlorinated biphenyls) or heavy metals such as mercury and lead.

 

Before you buy any fish oil supplement, ask the clerk if you can open the bottle or jar and smell the contents. A fishy smelling fish oil supplementation means it is rancid. Rancid fish oil is not going to help your heart at all and may actually hurt it.

 

Q. That leaves CoQ10. Why is it important for Jane and Earl?

A. CoQ10, also known as ubiquinone, is the premier heart supplement! CoQ10 is part of our energy producing system. It works directly in the mitochondria of each cell. Mitochondria are highly specialized structures within each cell and are often referred to as powerhouses. These tiny energy producers generate 95% of the energy the body requires. The number of mitochondria in a cell depends on its function and energy needs. The heart has very important functions and requires a vast amount of energy. Thus, the heart has a lot of mitochondria or little powerhouses.

 

CoQ10 is incredibly crucial to the health of our hearts. Especially to hearts that are pumping blood with too much cholesterol. But, in a dangerous paradox, CoQ10 levels can become dangerously depleted when physicians treat high cholesterol in their patients with certain medications. The so-called “statin” drugs (Mevacor/lovastatin and Crestor/rosubastatin are two examples) are powerful and medications prescribed to lower harmful cholesterol levels. However, one very harmful side effect they share is that they deprive cells of CoQ10. While some physicians are aware of this serious side effect and tell their patients to take at least 400 mg of CoQ10 each day, most are not. The result? Any good the statin drugs may be doing is actually negated by their depletion of CoQ10.

 

Q. How does CoQ10 actually work? Has it been studied in heart disease?

A. Yes, it has! CoQ10 has been extensively studied in heart disease. This natural nutrient is present in every nucleated cell in our body (the only cells that don’t contain CoQ10 are red blood cells). Heart cells, however, are absolutely loaded with CoQ10. Its job is fairly simply – CoQ10 is vital to the production of adenosine triphosphate (ATP), the compound our body uses for 95% of its energy needs.

 

In 1998, 144 patients who had been admitted to the hospital after a heart attack, participated in a CoQ10 study. Half of the patients received 120 mg of CoQ10 a day in addition to the usual treatments given to heart attack patients. The other half, the control group, received the usual treatments and a placebo, but no CoQ10.

 

The results showed that the group taking CoQ10 had less irregular heartbeat, experienced less angina (a type of heart pain), and had much better function in the left ventricle (the most essential chamber of the heart), compared to the placebo group. Total deaths due to sudden heart failure or another heart attack were also reduced in the CoQ10 group.

 

Q. What if I have already been diagnosed with Congestive Heart Failure? Will CoQ10 still help me?

A. CoQ10 has been proven in study after study to help slow down the destruction that occurs in congestive heart failure (CHF), a serious heart disease, and heal the heart muscles damaged by heart attacks. In fact, heart attacks often occur when the body’s CoQ10 levels are low.

 

In a CHF study, patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the researchers introduced a catheter into the right ventricle of the patients’ hearts to determine the degree of muscle damage CHF had caused. In the group who took CoQ10, the pumping ability of the heart improved significantly. The placebo group’s hearts did not. The researchers conducting the study recommended that people with CHF add CoQ10 to the other medications they need to take to stay alive and well.

 

Q. Are some types of CoQ10 better than others?

A. Indeed they are. CoQ10 products are not created equally. The key to this natural medicine is the quality of the manufacturing. Take a CoQ10 supplement that’s been used in research conducted by prestigious universities (it will tell you this right on the label). Researchers want the best CoQ10 for their studies. You want the best CoQ10 for yourself and your loved ones.

 

The best CoQ10 has to meet the following criteria:

1. Must be easily absorbed during the digestion process so that it can get into the

bloodstream.

2. Must reach the mitochondria in the cell.

3. Must be proven effective in studies.

4. Must be safe and free of impurities.

 

Q. It sounds as if CoQ10 is only for people with moderate or high risk factors. Can others benefit from this supplement?

A. Many people, including those like Fred with low risk factors or no risk of heart disease take CoQ10 every day. CoQ10 supplements may reduce your risk of cancer, prevent gum disease, and help certain nerve cells work more effectively.

 

Conclusion

Understanding your personal risk factors, making it better lifestyle choices, taking a multivitamin formulated for your heart, an enteric-coated fresh garlic supplement, fish oil supplement with Omega-3 fatty acids, and CoQ10 – the heart’s super-nutrient – can help keep your heart healthy and strong.

 

Helen Keller, the famous lecturer and author, who was both blind and deaf wrote, “The best and most beautiful things in the world cannot e seen or even touched. They must be felt with the human heart.”

 

Healthy hearts have the most opportunities to “feel” the best and are the most beautiful thing our world has to offer.

 



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Med schools failing on nutrition teaching
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Date: September 19, 2006 05:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Med schools failing on nutrition teaching

Almost 60 percent of US medical schools do not meat recommendations for nutrition education for med students, producing physicians – the first port of call for nutrition advice for many consumers – who may have inadequate nutrition knowledge.

Twenty years ago the National Academy of Sciences (NAS) reported that 21 hours of education in nutrition was required but found that many medical schools did not offer nutrition courses.

Surveys show that hasn’t changed much, so it appears we are producing a pool of physicians who feel largely unprepared to counsel their patients about nutrition.

“Sooner or later, everyone sits down to the banquet of consequences.” Robert Louis Stevenson.

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Remifemin symptomatic relief, scientifically supported*
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Date: August 26, 2006 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Remifemin symptomatic relief, scientifically supported*

Remifemin

 

Symptomatic Relief, Scientifically Supported*

 

The only RemiSure black cohosh

 

Unique to Remifemin® - Exclusive standardized isopropanolic black cohosh extract, subject of over 90 scientific papers.

Proven Effective – The most clinically studies natural intervention for menopausal symptoms with over 40 years of use worldwide*

 

  • Relief from hot flashes, night sweats, mood swings, irritability, and related occasional sleeplessness*
  • Particularly in women in early stages of menopause*

 

Safe – Completely hormone free

 

  • Works naturally without plant-based estrogens that can affect breast and uterine cell growth
  • Can be used safely by women with a history of breast cancer who cannot take estrogen

 

Efficacy

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

1. Twelve-week, randomized, multicenter, double-blind clinical trial comparing the efficacy and tolerability of Remifemin® in the treatment of climacteric complaints compared with placebo.  The primary efficacy measure was the change from baseline on the Menopause rating Scale 1.

·          Remifemin® effectively relieved menopausal symptoms, particularly in women in the early stages of menopause*

·          Most significant reduction was in hot flash occurrence*

·          Other symptoms resulting in significant reduction include: psyche (irritability and memory), and atrophy (vaginal dryness)*

·          No significant adverse effects reported

40mg qd

Osmers R, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms.  Obstet Gynecol. 2005 May; 105(5):1074-83.

2. A review of 29 randomized controlled trials of complementary and alternative therapies for menopausal symptoms.

·          Black cohosh is one of the only herbal remedies shown to be effective for menopausal symptoms, especially hot flashes*

 

Kronenberg. F. Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002 Nov 19;137(10:805-13.

3. Four-week, pilot study, open clinical trial of menopausal women with hot flashes, including women with a history of breast cancer.

·          Remifemin® reduced mean daily hot flash frequency by 50% after 4 weeks*

·          Overall, participants reported less trouble with sleeping, less fatigue, and fewer night sweats* 

·          No participants stopped therapy because of adverse effects

40mg qd

Pockaj BA, et al. Pilot evaluation of black cohosh for the treatment of hot flashes in women.  Cancer Invest. 2004;22(4):515-21

4. Double-blind study involving the use of Remifemin® in women ages 43 to 60 with menopausal complaints lasting 6 months.

·          Majority of woman saw a 70% reduction of physical and emotional symptoms after 12 weeks, including hot flashes, night sweats, mood swings, and irritability*

·          Significant improvement was noted after 4 weeks use*

·          Remifemin® works safely and effectively to treat menopause symptoms without affecting hormone levels or vaginal cytology (pap smear)*

40mg qd

Liske J, et al. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizome): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med. 2002 Mar; 11(2): 163-74

5. Double-blind, 6 month study in hysterectomized women under 40 with at least one ovary.

·          As effective as estriol, conjugated estrogens, or hormone combinations at decreasing physical menopausal symptoms at 4, 8, 12, and 24 weeks*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Lehmann-Willebrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa. Zentralbl Gynakol. 1988; 110(10):611-8

 

6. Women aged 45 to 58 with menopausal complaints were studied in a double-blind, 12 week, placebo-controlled trial.

·          Remifemin® decreased physical symptoms of menopause by approximately 60% (Kupperman menopausal indeed)*

·          Daily hot flashes decreased by 86% in the Remifemin® group(from 4.9 to 0.7 per day)*

·          Emotional complaints were also dramatically reduced*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Stoll W. Phytopharmacon influences atrophic vaginal epithelium: Double Blind study – Cimicifuga vs. estrogenic substances. 1987.

 

Safety

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

7. in vitro, MCF-7 cell culture model to determine estrogen-agopnist and antagonist activity of commercially available herbal menopause preparations containing red clover, soy black cohosh, or a combination of herbs.

·          Remifemin® had no effect on estrogen-sensitive cells in vitro.

·          Results suggest safety for women with a history of breast cancer who cannot take estrogen.

In Vitro(10^3-10^5 dilutions)

Bodinet C, Freudenstein J. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation.  Menopause. 2004 May-Jun;11(3):281-9.

8. Six-week, in vivo investigation of Remifemin®’s ability to stimulate estrogen-receptor positive cells in an animal model

·          No estrogen stimulating effects were found.

·          Prolactin, follicle-stimulating hormone, and luteinizing hormone levels were unchanged.

0.714m 7.14 or 71.4mg/kg/day

Freudenstein J, et al. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res. 2002 Jun 15;62(12):3448-52.

 

 

 

9. Comprehensive review examining all published literature pertaining to pre-clinical and clinical safety of various forms of Cimicifuga racemosa, as well as FDA and World Health Organization (WHO) adverse event reporting systems, monographs, compendia, internal unpublished data from a major manufacturer, foreign literature, and historical, anecdotal report.

·          Uncontrolled reports, postmarketing surveillance, and human clinical trials of more than 2,800 patients demonstrate a low incidence of adverse events (5.4%).

·          Of the reported adverse events, 97% were minor and did not result in discontinuation of symptoms, and the only severe events were not attributed to Cimicifuga treatemtn.

·          Confirms the safety of specific Cimicifuga extracts, particularly isopropanolic preparations (Remifemin®), for use in women experiencing menopausal symptoms and as a safe alternative for women in whom estrogen therapy is contraindicated *.

Various

Low Dog T, et al. Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause: Journal of the North American Menopause society. 2003;10(4):299-313.

 

Relevant Reports and Guidelines

ORGANIZATION

PUBLICATION

EXCERPT OF KEY CONTENT

American Botanical Council

The ABC Clinical Guide to Herbs including a black cohosh monograph issues September 2002

“Of 10 clinical studies, including a total of 1,371 participants, nine of these studies demonstrated positive effects for menopausal symptoms.  Numerous clinical trials with varied methods and designs have been conducted on the standardized isopropanolic/ethanolic extract of black cohosh root, Remifemin®, from 1981 to the present.”

National Institute of Health

Questions and Answers About Black Cohosh and the Symptoms of Menopause issued October 2002

“Other preparations of black cohosh have been less well studied than Remifemin® …black cohosh is used primarily for hot flashes and other menopausal symptoms.  A number of studies using various designs have been conducted to determine whether black cohosh affects the menopausal symptoms… To provide more definitive evidence on the effects of black cohosh on menopausal symptoms, NCCAM is funding a 12-month, randomized placebo controlled study to determine whether treatment with black cohosh is effective in reducing the frequency and intensity of menopausal hot flashes.”

The North American Menopause Society

Alternatives to Hormone Replacement Therapy: Suggestions for the North American Menopause Siciety issued July 2002

Reseach suggests that mild hot flashes can be relieved by consuming a serving of soy foods daily or taking a supplement of black cohosh.”

 

Responding to the need for alternative menopausal symptom relief*

 

Natural, Safe alternative to HRT for menopausal symptoms*

 

  • Remifemin black cohosh was as effective as HRT for menopausal symptoms*

 

Superior Manufacturing Quality

 

  • Prepared according to Good Manufacturing Practice (GMPs) which ensure delivery of a product with the highest quality and consistency
  • Convenient dosing – one 20mg tablet twice a day (one in the MORNING, one in the EVENING)
  • 100% RemiSure black cohosh – not a combination of herbs

 

VitaNet Recommends Remifemin

 

  1. Remifemin unique standardized isopropanolic extract is the most widely studied and clinically tested natural alternative treatment for relief of menopausal symptoms.
  2. Remifemin black cohosh proven effective in reducing menopause and peri-menopause symptoms, including hot flashes, right sweats, mood swings, and irritability without estrogenic effects.
  3. Used safely by millions of patients worldwide for over 40 years.  Remifemin has been proven effective and is the most clinically studied natural intervention of menopause.
  4. Remifemin doesn’t have the side effects that are experienced with hormonal drugs prescribed for the relief of menopausal symptoms.

 

Lit source: Enzymatic therapy.

*this statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treate, cure, or prevent any disease.



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Perplexed about Protein? immunoglobulins to boost the immune system.
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Date: April 29, 2006 01:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Perplexed about Protein? immunoglobulins to boost the immune system.

The Wellness Revolution

Perplexed about Protein?

As protein and whey powders have advanced in popularity, the confusion about them has grown. In particular, protein processing technology has advanced by leaps and bounds; consumers are being presented with protein claims and counter-claims that are highly contradictory.

The confusion is part of a rapid growth. Little Miss Muffet’s quiet dish of curds and whey has expanded from a minor sideline aid for weight lifters, with sales increases around to percent a year, into an explosive $1 billion a year industry, with some companies announcing sales growth of 110 percent in just the last year.

The increase in market is from whey’s expanding appeal. As new technology has made whey’s nutritive value beneficial to a wide range of consumers, more people are using whey, and whey is being added to more products. The problem is, those advanced nutritive qualities are not included in all whey products. The fantastic immune benefits, for example, apply to only the top tier of whey products.

Protein Quality

The standard of protein quality—the ability to provide indispensable amino acids—is judged on the basis of digestibility, nutrients, and amino acid composition. Whey has historically been acknowledged as on of the best sources of high quality protein.

With the increasing popularity of whey, attention on new processing methods has raised the bar on quality, and new products have greatly expanded nutritional values. What may have been an acceptable high-quality whey protein a few years ago, no longer makes the grade. Tony Lucchesi, Natural Sales Trainer at Source Naturals says, “The different processing methods have changed the entire protein market.”

He explains, “In separating casein from whey, (a process used to make cheese), most processing methods use heat, chemical modification, or pH adjustments. These all damage the native protein structure. The result is little or no biological activity in the whey product. All the low temperature drying and micro-filtration won’t help if the raw material is denatured before a protein is dried and brought to market.”

Damaged Proteins

Damaged protein may have been acceptable a few years ago, but it isn’t now. Lucchesi continues, “Animal experiments have shown that polypeptides—whole, non-denatured proteins—have greater nutritional value than protein isolates.”

Protein isolates are what is left after the pasteurization process. The protein has traditionally been “Cross cooked” out of its normal balance. “What you have left are incomplete bits and pieces of whole protein,” he says. These protein bits have only partial nutrients.

New Whey

The latest introduction to the protein category are concentrates, which are intact, biologically-active whole proteins. The entire difference is in the processing; high heat, acids, and traditional methods of separating the caseins from the whey are no longer used. The new processing preserves the nutrients of the protein. This is the method that is the basis for a new Source Naturals whey product, True Whey.

Lucchesi says, “TRUE WHEY is different in that it was designed to provide nutritional support for enhanced immune function. The entire process was designed for nutritive value. The preservation of these nutrients—lactoferrin, glutamine, immunoglobulins—give TRUE WHEY a huge benefit to athletes, children, and anyone interested in boosting their immune system.”

Per serving, TRUE WHEY offers 8 grams of un-denatured protein that includes 900 mg immunoglobulins and 190mg of lactoferrin. Its vanilla flavoring has gotten very high reviews, and it has a two-year shelf life. It appears that the bar has truly been raised in the whey protein category!

THE TRUE WHEY 16 oz. from SOURCE NATURALS

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Cholesterol Support FAQ's
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Date: January 06, 2006 12:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cholesterol Support FAQ's

Cholesterol Support FAQ's

What ingredients does NOW® Cholesterol Support contain, and how many capsules should I take daily?

NOW® Cholesterol Support is specially formulated to support your body’s normal metabolization of cholesterol. This supplement contains essential nutrients like Vitamins C & E, and Tocotrienols derived from natural source Vitamin E. The active ingredients include Chromium, Guggul Extract, and PureGar® Garlic, specialized dietary ingredients that work synergistically to support healthy cholesterol metabolism.

Has the formula for NOW® Cholesterol Support been changed?

Recently the U.S. FDA ruled that Red Rice Yeast extract has a drug effect on the body and has banned dietary supplements from containing this ingredient.

In order for NOW® to continue to offer Cholesterol Support with Red Rice Yeast extract, we would have to register this supplement as a drug, which would entail years of clinical trials. Due to the complications associated with this ingredient, NOW® has decided to reformulate this top seller. We’ve increased the levels of certain key nutrients to account for the absence of Red Rice Yeast extract, and this new formulation is as effective as the original. Disclaimer: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

CHOLESTEROL SUPPORT 90 VCAPS 1 from NOW


Nutrition Info
Servings Per Container: 30
Serving Size: 3 Vcaps®
Amount Per Serving % Daily Value
Calories 5
Total Carbohydrate 1 g < 1%*
Dietary Fiber 0.5 g 2%
Vitamin C (from Ascorbyl Palmitate) 8 mg 12%
Vitamin E (as d-alpha Tocopherol) 18 IU 30%
Chromium (from Chromium Chelavite®) 200 mcg 170%
Pure-Gar®; Garlic (Allium sativum) 300 mg
Guar Gum (Cyamopsis tetragonoloba) (Seed) 300 mg
Guggul Extract (10% Guggulsterones) 220 mg
Tocotrienols (from Red Palm Oil) 33 mg
Alpha Tocotrienols 10 mg
Beta Tocotrienols 1 mg
Gamma Tocotrienols 17 mg
Delta Tocotrienols 5 mg
Policosanol (min. 60% Fatty Alcohol from Phytowaxes) 10 mg
* Percent Daily Values are based on 2,000 calorie diet.
† Daily Value not established.






Details

Serving Size: 3 Vcaps®

Suggested Use: As a dietary supplement, take 3 Vcaps® 2 times daily, preferably with meals.

Free of: salt, yeast, wheat, milk, soy or preservatives.

Other Ingredients: Cellulose (capsule), Maltodextrin, Gelatin, Silica and Magnesium Stearate (vegetable source).

Warnings: Not intended for pregnant or lactating women. Individuals currently using 'Statin' drugs should consult their health practitioner before using. Please discard the inedible freshness packet enclosed.


Recommended by Dr. James Balch, Cholesterol Support TM is a dietary supplement specifically formulated to support your body's natural metabolism of cholesterol.* In addition to this effective supplement, we recommend a diet low in saturated fats and regular aerobic exercise.




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Vitamin C FAQ's
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Date: December 27, 2005 05:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin C FAQ's

Vitamin C FAQ's

What is Calcium Ascorbate?

Calcium Ascorbate is a buffered salt (mineral) form of the water-soluble antioxidant Vitamin C (ascorbic acid). Calcium is reacted with ascorbic acid to buffer the acidic nature of this vitamin, making it more gentle for the special needs of those who may have a sensitive gastrointestinal tract. The pH of this buffered mineral Ascorbate is approximately 6.8—7.4 as compared to ascorbic acid that is about a pH of 2.5. Calcium Ascorbate provides approximately 10% elemental calcium.

What does Calcium Ascorbate do?

Ascorbate (vitamin C) is a reducing sugar (has a reactive ene-diol structure) that is involved in biochemical processes such as hydroxylation of proline and lysine utilized in the formation of collagen and healthy connective tissue. A deficiency in Ascorbate results in a disease called scurvy which manifests as weakened collagen fibers, rotting teeth, delayed healing and open sores on the skin. Ascorbate is involved in many other vital functions such as the mobilization of iron, stimulation of immune system and as an anti-oxidant for scavenging of reactive free radicals.

Is this a necessary vitamin or can our bodies make enough to satisfy our needs?

Many plants and animals do not need to consume foods high in ascorbic acid to meet their need for Vitamin C because they are genetically programmed to produce enzymes that convert glucose into ascorbic acid. Unfortunately humans have only 3 of the 4 enzymes necessary for internal production of ascorbic acid, therefore we must satisfy our physical needs for this important vitamin through our intake of foods rich in vitamin C and/or take a good supplement.

What is the function of the Citrus Bioflavonoids?

Bioflavonoids are biologically active Flavonoid compounds found throughout the entire plant kingdom. Since the discovery of Flavonoids in 1936 when they were first isolated from lemons and called citrin and Vitamin P over 4,000 different types have been characterized. Though there are several forms of Bioflavonoids in the complex the predominant form is Hesperidin. These Flavonoids exhibit beneficial effects on capillary permeability and therefore support blood flow. They are antioxidants that work synergistically with Vitamin C as well as exhibiting anti-inflammatory activity.

Why are there color variations in your different Vitamin C products, and are they safe to take?

Most natural Vitamin C products vary in color from batch to batch and bottle to bottle. There are normally variations in the color of the raw material used during manufacturing, which is a normal occurrence. This is due to natural color variations in the source of the Vitamin C – generally, you will find C supplements to range in color from a light tan color to a light gray color.

Over the course of the shelf-life of a Vitamin C supplement, oxidation can cause a slight change in color, so you may find the light tan C-1000 you bought has changed to a darker tan six months later. This is a normal occurrence, and the product is safe to use up until the expiration date, and even beyond. NOW® is generally conservative with expiration dates, so a Vitamin C product is still safe after the date, it just may not be as effective due to oxidation.

Why does your Ester-C Complex say 625mg on the front of the label but list 500mg on the Supplement Facts panel? The key word is “complex”. Ester-C Complex is a combination of ascorbic acid (natural Vitamin C) and Calcium Ascorbate, which ultimately yields 500 total mg of Vitamin C. It is complexed with Calcium Ascorbate and other metabolites for greater absorption and faster utilization by your body. So the total complex is 625mg of Ester-C Complex, which yields 500mg of natural Vitamin C as ascorbic acid.

NOW Ester-C Pure Powder states the serving size is ½ teaspoon. How much Vitamin C am I getting with this serving size? ½ teaspoon of Ester-C Pure Powder is equivalent to 2000mg of natural Vitamin C and 250mg of Calcium.

Can I pour the powder in NOW® Vitamin C capsules into a liquid instead of swallowing the capsule? Many people do not want to or cannot swallow capsules, tablets or softgels, for various reasons. Encapsulated Vitamin C products from NOW® can be opened and dumped into a liquid for consumption. Juice or water is recommended if you choose this method. However, taking Vitamin C with water on an empty stomach is the recommended method of ingestion. We do not recommend trying this method with Vitamin C in tablet form, although you can grind or smash a tablet into powder form and add to water or juice. If you choose to do this, use a mortar and pestle for best results and minimal loss of product. Why go through the trouble when NOW® carries Vitamin C in a powdered form already. Save yourself time and trouble by ordering this form instead. Disclaimer: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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GliSODin Anti-Aging and Antioxidant Protection
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Date: December 19, 2005 08:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GliSODin Anti-Aging and Antioxidant Protection

GliSODin Anti-Aging and Antioxidant Protection

  • Superior Anti-Aging Formula
  • Stimulates Natural Antioxidant Defenses
  • Helps Protect DNA
  • Reduces Oxidative Stress
  • Prevents Oxygen Related Cell Damage

In the time it takes you to finish reading this article, you, your body and your cells will have aged. Some, more than others. Nevertheless, every second that ticks away should serve as a reminder that our time here is temporary. How much time we actually end up with depends on many things. Diet. Lifestyle. Environment. Superoxide Dismutase? I’ll explain. What some of the healthiest individuals fail to realize is that our bodies age from the inside out. Aging is not the result of passing time, but rather the result of what we’re exposed to environmentally, physically and chemically. It is the integrity of our cells, not our clocks, that determine how smooth the aging process fares.

Each day, we’re subjected to millions of elements that affect us in ways seldom seen, felt or noticed. From the moment we’re born, we rely on our cells to work around the clock - producing energy, fighting infections and sustaining life. These same cells eventually determine the rate at which we show (or hide) our age.

Taking into consideration that our planet has no shortage of toxins & germs, the need to safeguard our cells becomes very real. Constant exposure to exhaust, secondhand smoke, heavy metals, lead, fluoride and uncountable other noxious compounds should ideally provide us with nothing more than a routine immune system workout. Unfortunately, over long periods they hinder our “resistance” abilities and become stepping stones to accelerated aging.

Antioxidants. We’ve all heard the term before, and may even have a general understanding of their role. But to better grasp just how vital they are, it helps to know what’s happening at the cellular level. Free radicals are unstable molecular thieves that often lack electrons. To compensate, they rob healthy cells - a process better known as oxidation. Antioxidants work with the immune system to prevent oxidation, and clean up the mess it leaves behind. Hence, the name.

There are two types. Exogenous antioxidants are derived from our diet and include vitamins A, E, and C along with others such as alpha lipoic acid, selenium, CoQ10, grape seed, pycnogenol and zinc. To date, we’ve been limited to exogenous antioxidants as a way to increase the rate at which our body wards off oxidation. They are not, however, our first line of defense. At birth, each and every one of us is equipped with three primary endogenous enzymatic antioxidants; SOD (Superoxide Dismutase), Glutathione Peroxidase (GPx) and Catalase.

While both types of antioxidants are beneficial, we’ve become reliant on those from the diet to compensate for our inability to boost the effectiveness of our 3 primary antioxidants. For years, researchers have been examining ways to enhance the activity of our built-in bodyguards. One in particular, Superoxide Dismutase (SOD) has been of foremost interest. SOD targets what many researchers regard as one of our greatest health threats and aging accelerators - Superoxide radicals. These highly reactive, merciless molecules incite enormous amounts of oxidative stress and are capable of wreaking havoc on healthy cells. When cells are left unprotected by SOD, the results can be disastrous - respiratory problems, premature aging, memory loss, cardiovascular challenges, vision failure and joint structure damage, among others.

Until now, we’ve been at the mercy of our natural SOD reserves to fight superoxides. Researchers have been working feverishly to produce an effective oral SOD supplement, but have continually encountered a frustrating hurdle - exposure to gastric acid denatures SOD, rendering it useless. As a result, the only effective way to supplement SOD was through injections. These, however, only yielded short-term spikes. And then something remarkable happened that changed everything. Nutrition scientists in France determined that by combining Cucumus melo (a melon high in SOD) with a wheat gliadin stabilizer, it would be possible to prevent SOD from deteriorating in the digestive tract, while preserving it in the blood for extended periods. Not only is this the answer to a puzzle that has plagued researchers, it’s a breakthrough that will impact the life of anyone seeking longevity and vitality.

As the first proven oral SOD supplement ever introduced to the public, GliSODin® has taken antioxidant protection, immune support and antiaging science to an entirely new level. The primary function of GliSODin® is to scour the body for superoxide radicals and reduce them to less reactive ions that can be swept away; a process known as dismutation. In addition, GliSODin® reduces the oxidation vulnerability of healthy cells, protects mitochondrial activity and safeguards DNA structure.

What’s most remarkable is that GliSODin® has actually been shown to stimulate the body’s own natural production of all three enzymatic antioxidants, including SOD. For the first time in history, we will have the ability to enhance the effectiveness of our body’s primary defense mechanism.

New GliSODin® from NOW® represents the ultimate in antioxidant protection. By increasing one’s level of SOD while stimulating the natural production of Glutathione Peroxidase and Catalase, GliSODin® delivers antioxidant protection unlike any previously released dietary supplement. Remember, the aging process begins at a level that we simply can not see, the cellular level. Shielding your cells from superoxide damage is one of the smartest steps you can take against aging before your due time. GliSODin® has made this a reality.



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CRN Steps Up Efforts Against Calif. High School Sports Supplement Bill
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Date: September 26, 2005 09:16 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CRN Steps Up Efforts Against Calif. High School Sports Supplement Bill

Washington - The council for Responsible nutrition (CRN) has stepped up its efforts to amend Calif. S.B. 37, an oft-amended bill that originally sought to protect high school athletes from performance-enhancing substances, but has been recently changed to focus on two supplements—ephedra and DHEA—already illegal to California minors, As well as synephrine, which is on the U.S. Anti-doping Agency (USADA) watch list. In addition to its regular opposition efforts, including a position statement, CRN gave each legislator a poster, detailing concerns about the narrow focus on the bill and the possible motives behind the bill’s current focus on dietary supplements.

“We are not opposed to preventing young athletes from abusing harmful products”, said Judy Blatman of CRN. “We are suggesting a simple amendment—change the words ‘dietary supplements’ to ‘performance enhancing substances.’ Broadening the language to include steroids, growth hormones and illegal drugs would encourage athletes to avoid use of harmful substances.”

The bill, created by Jackie Speier (D-Hillsborough), was introduced last year but was vetoed by Gov. Arnold Schwarzenegger for being to “broad, vague and unfocused,” according to Blatman. Schwarzenegger then drew fire for his connections to supplement marketers and several sports nutrition-based magazines.



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Pain - Post Op and Relaxation
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Date: July 13, 2005 09:24 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pain - Post Op and Relaxation

Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR.

"Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music.

Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good.

"These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization.

Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz.

On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed.

Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery."

Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill.

-----------------------------

Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association.

The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998.

A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study.

There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity.

Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density.

The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group.

These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70.

"We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research.

"Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus.

As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D.

Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine.

-----------------------------

Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds.

"The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander.

"When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt."

Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain.

These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood.

"This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added.

------------------------------

Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher.

Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal models, natural killer cell activity was suppressed by physical stress or surgery, resulting in a significant increase in tumor development.

These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study.

"We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University.

Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery.

The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page.

"Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk."

The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.

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Supports Healthy Blood Sugar Levels-Herbally
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Date: July 05, 2005 10:18 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Supports Healthy Blood Sugar Levels-Herbally

  • Supports Healthy Blood Sugar Levels-Herbally
  • Ancient Spices for Modern health
  • Weight Loss & Lean Muscle Mass- An Important Key to Increased Insulin Sensitivity

  • Supports Healthy Blood Sugar Levels-Herbally

    The introduction of refined sugars into the modern diet has had tremendous negative health consequences on world health. For example, diabetes, especially insulin-independent diabetes (Type 2), is growing rapidly in the United States particularly among children. This type is partly due to the inability of insulin to effectively transport sugar to receptor sites and into cells, where the sugar can be metabolized. Instead of being "burned up," sugar builds in the blood, creating a potentially serious health problem. This inefficiency can occur for a number of reasons, including: insufficient insulin production due to pancreas dysfunction (though many Type 2 diabetics produce excess insulin); the inability of insulin to carry sugar to receptor sites; a defect in the insulin; or a defect in the receptor that does not allow for the sugar to be transported through the cell membrane. Even if one does not have diabetes, it is important to maintain healthy blood sugar levels through proper diet, exercise, and weight management. This is especially important in children who were recently found to obtain 14% of their daily calories from sweet drinks (sodas), overtaking white bread as the primary source of total daily caloric intake. Regardless of the reason, a number of botanicals, in addition to key lifestyle recommendations, have been shown in modern research to support healthy blood sugar levels by enhance sugar metabolization. (Cinnamomum aromaticum syn. C. cassia*) is one botanical that has been shown to have a positive effect on potentiating the effects of insulin.

    *The study referrd to the material used as Cinnamomum cassia. The officially accepted botanical nomenclature has changed and is now Cinnamomum aromaticum.

    Ancient Spices for Modern health

    Spices have been used historically to increase metabolism, raise body heat (thermogenesis), improve digestion and assimilation, and potentiate the effects of other substances. For this reason, in many herbal traditions, small amounts of hot pungent spices were added to many traditional compounds. Regarding sugar metabolization, a study by the United States Department of Agriculture (USDA) looked at the potential effects of 49 spices on insulin function (Broadhurst et al. 2000). These researchers found that cinnamon was the most bioactive in directly stimulating cellular glucose metablosim, i.e. the ability of cells to utilize sugar. The same researchers followed up with constituent studies and determined that it was water-soluble compunds in the extract that had this insulin-potentiating effect. This was followed by a clinical trial (60 subjects), also with involvement of the USDA, on the effects of cinnamon for potentiating insulin. The equivalent of 1, 3, and 6 grams (g) of cinnamon powder (approximately 1/4 to 1.5 teaspoons) reduced blood glucose levels 18-29% in 40 days (Khan et al. 2003).

    There was a significant increase in efficency between the 1 and 3 g doses, but an insignificant increase between the 3 and 6 g doses. One mechanism of action that has been postulated is that cinnamon increases the activity of PI-3 kinase, an enzyme that is critical in regulating the ability of glucose to be transported into the cell, where it can be utilized as energy. In addition to its ability to potentiate insulin, the cinnamon also supported healthy triglyceride and cholesterol levels, both important health benefits in general.

    There is an additional benefit of using cinnamon for many Americans; like many spices it is a potent thermogenic agent. This means it can be used as a healthy adjunct to a weight loss program that includes dietary modification and proper exercise. The excessive consumption of simple sugars in conjunction with poor diet and sedentary lifestyles can cause unhealthy blood sugar levels while providing themogenic support can have long-lasting health benefits.

    There have been a number of popular articles on the recent studies. This had led some to ask if crude cinnamon powder can be used with the same effect and safety. This has not been tested. As with all spices, cinnamon is rich in essential oils. Essential oils have beneficial effects, but the insulin-potentiating effect was found to occur in the water extract. This would suggest that many of the oil soluble compunds were lost in the processing. Also, essential oils can be stimulating and irritating, one of the reasons they are generally used in small amounts as flavoring agents. Therefore, it would be best to look for products that contain the water extract to ensure you are delivering the preparation that most closely reflects the preparation used in the studies.

    Weight Loss & Lean Muscle Mass- An Important Key to Increased Insulin Sensitivity

    Maintaining healthy weight and increasing lean body mass are key components in the supporting healthy blood sugar levels. Recently it was reported that only two days of inactivity resulted in a decreased level of insulin sensitivity. Therefore, supporting healthy blood sugar levels is extremely important for those wanting to maintain a healthy lifestyle. In obesity, or in those with a significantly higher percentage of body fat over lean muscle (body mass index greater that 25), it is very difficult for insulin to do its job effectively. The reason is quite simple: fat cells can prevent insulin from actually reaching insulin receptor sites; the fat physically blocks the receptor, and the sugar that should have been burned off through cellular function remains in the blood. It is important to know that, in such cases, there is often nothing at all wrong with the pancreas (the insulin-producing organ), the insulin, or the receptor sites. The fat simply prevents insulin and sugar from reaching their target. In many cases, people are over-producing insulin in an attempt to get more sugar to the receptor sites. After awhile, the pancreas can become exhausted and no longer produce adequate amounts of insulin. Therefore, a primary therapy for supporting healthy blood sugar levels is proper weight management through diet and exercise.

    References

    Broadhurst CL, Polansky MM, Anderson RA. 2000. Insulin-like biological activity of culinary and medicinal plant extracts in vitro. J agric Good Chem. 48(3):849-852. Khan A, Safdar M, Khan M, Khan K, Anderson R. 2003. Cinnamon improves glucose and lipids of people with Type 2 diabetes. Diabetes Care 26912):3215-3218.

    Roy Upton is trained in Western and traditional Chinese herbalism, and has been a professional herbalist for 18 years. He is past president and current vice-president of the American Herbalists Guild (AHG) and is also executive director and editor of the American Herbal Pharnacopoeia. an organization dedicated to the development of authoritative monographs on botanicals used in supplements and medicines. Roy is general manager of Planetary Formulas and a memeber of the Standards Committee of the American Herbal Products Association. He is the author of several books, including St. John's Wort and Echinacea in the Keats Publishing Good Herb Series and co-author of the Botancial Safety Handbook, published by CRC Press. Roy lectures and writes extensively.

    Disclaimer: The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



    --
    Vitanet ®


    Also try: Now Vitamins brand for low priced vitamins!

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    Introduction
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    Date: June 22, 2005 09:40 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Introduction

    Introduction

    Next time someone you know puts a burger on a charcoal grill, notice how the fat drops, sizzling, onto the briquettes beneath. As the drippings burn, the chemical content changes. This really is what burning is, a chemical change from a complex form of the substance to a more simple form. As it changes, many chemicals emerge—some harmless, others less so. One of those chemicals, benzopyrene, can cause mutation of bacteria in the test tube, and that led some scientists to believe it might cause cancer.1 Benzopyrene becomes part of the smoke that rises from the charcoal to settle back on the surface of a cooking burger. This was known as far back as the 1970s, and, for those interested in good health, it became another reason to cut meats from the diet and replace them with healthy grains and vegetable products. Many left it at that. Thankfully, scientists began digging more deeply into this phenomenon, measuring other chemicals and other methods of cooking. One such scientist was Michael Pariza. In 1978, Pariza studied heterocyclic amines to see if they were “mutagenic,” that is, if they would cause bacteria to mutate in the test tube. He found that burgers can be quite safely cooked with care.2 But what changed the direction of his research was an entirely original discovery, separate from what his paper set out to find. This discovery has shaped his career since and may well, in the years to come, help thousands, indeed millions, of people improve their health. What he discovered was that something in hamburger has a “mutagenic inhibitory” effect. That is, something in meat seemed to counteract the bad effects of these mutagens, indeed was an anti-mutagen. In his research, Pariza used a popular scientific test called the Ames Test, named for a scientist at the University of California at Berkeley. This test is still used today for its simplicity by numerous scientists. The test requires enzymes form rat livers stimulated with certain chemicals. Scientists put these enzymes and the possible mutagen onto bacteria. They observe the bacteria in a microscope to see if they have mutated. Pariza changed the experiment slightly. Instead of stimulating rat livers, he used enzymes from normal rat livers. The results showed this anti-mutagenic effect, but just what substance caused it was still a question. For nearly another decade, Pariza and others tried to isolate this substance. Finally, they managed to do so in 1987.3 Call it a previously undiscovered nutrient, one, by the best research now available, that seems essentially vital for optimal health. The substance is CLA— conjugated linoleic acid. Laboratory studies using animals show:

  • • CLA has powerful anti-cancer potential.
  • • It seems to help keep arteries from getting clogged as easily.
  • • It helps a body deal with the cascade of effects that occurs when an infection sets in, helping animals, and potentially humans.
  • • It can help cut body fat while building lean muscle tissue, and that means animals are healthier and, perhaps, lose weight.
  • • Though this question is debated, many researchers believe it is a powerful antioxidant as well. Significantly, because of modern agricultural techniques, the amount of CLA in our diets today is much lower than it used to be, and that may, at least in part, explain America’s growing girth.

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    The A Team
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    Date: June 14, 2005 06:04 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The A Team

    The A Team

    by Gregory Meade Energy Times, October 11, 2004

    Want the A Team playing to improve your health? When you accumulate enough antioxidants to help you attack the molecular marauders out to mar your well-being, you improve your chances of avoiding illness.

    Nowadays you hear plenty of talk about the benefits of antioxidant nutrients. Antioxidants are the ammunition the body uses to fight off internal damage. They offer the body the means to fight against disease but, at the same time, your body must be in the position to use them optimally. That means getting enough sleep, consistently exercising and avoiding overly processed foods. Those lifestyle habits allow your body to garner its resources and effectively implement antioxidants in its quest for well-being.

    Your body has a love-hate relationship with oxidation: Can't live without it, often has trouble living with it. For instance, the production of energy in your cells requires oxidation. But the byproducts of that process, problematic molecules called free radicals, have to be chemically changed or eliminated to avoid the damage that results when they interact with other parts of the cell. Left unchecked, these molecular troublemakers can wreak havoc, oxidizing and punching holes in cell membranes and damaging other structures they contact. Antioxidant nutrients are used to defend against oxidation, quell these harmful destroyers and limit the potential harm they can cause.

    For a quick glimpse of one of your basic antioxidant defenses, look in the mirror. The color in your eyes represents antioxidant protection against oxidative injury from the ultraviolet rays in sunlight. Sunlight's energy sets loose free radicals every time it enters the lenses in your eyes. Pigments absorb this radiation and, in most cases, render it harmless.

    As part of your vision's defenses, two of the antioxidant pigments in your food, lutein and zeaxanthin, are deposited by your body in certain areas of your eyes-in a section called the macula as well as the lens (BJ Opthalmol 1998; 82:907-10).

    Lutein and zeaxanthin are classified as carotenoids, chemical relatives of beta carotene, the antioxidant pigment that makes carrots orange, and lycopene, the anticancer red coloring found in tomatoes. These fat-soluble nutrients are also present in algae. In both your eyes and plants, these nutrients absorb the destructive ultraviolet rays that give birth to free radicals.

    Blindness Protection

    Studies show that consuming large amounts of these pigments lowers your risk of a common form of blindness called age-related macular degeneration (ARMD) and drops your chances of age-related cataracts. (More than 30 million people worldwide suffer from ARMD, and cataracts is the leading cause of blindness across the globe.)

    When the sun's rays enter the eye, lutein and zeaxanthin absorb and filter out dangerous radiation before it can injure the macula. The macula is the central part of the retina that allows us to see very fine detail. Otherwise, over time, as the macula deteriorates, our vision worsens. In addition, some researchers believe these nutrients help lower your chances of cancer.

    Lutein and zeaxanthin are found in spinach, Brussels sprouts, corn, collard greens, green beans, egg yolks, broccoli, cabbage, kale, lettuce, kiwi and honeydew melons. The petals of yellow flowers like marigolds and nettles are also rich in these antioxidant nutrients.

    Broccoli Protection

    You can also increase your chances of better sight as you age by consuming sulphoraphane, an antioxidant found in broccoli. Researchers at Johns Hopkins University have found that sulphoraphane takes part in the body's efforts to shield eye cells from free radicals generated by ultraviolet light (Proc Natl Acad Sci 2004; 101(28):10446-51).

    The researchers who performed this study believe that unlike the antioxidant nutrients vitamin C and natural vitamin E, sulphoraphane acts as an "indirect" antioxidant. That means that while those two vitamins are used by the body to directly defuse the harmful oxidative force of free radicals (and then must be replaced or regenerated in the cells), sulphoraphane acts indirectly, boosting the body's immunity defenses. Because of that indirect action, researchers point out, sulphoraphane lasts longer in the body and may produce a more profound, long-term antioxidant effect.

    In other laboratory tests, researchers have discovered that sulphoraphane can kill Helicobacter pylori, a bacterium recognized 20 years ago as the cause of debilitating stomach ulcers and often-fatal stomach cancers (Proc Natl Acad of Sci 5/28/02). This research shows that sulphoraphane is even effective against antibiotic-resistant Helicobacter. Adding to its benefits, sulphoraphane can help kill bacteria both inside and outside stomach cells; when this bacteria hides inside of cells it is particularly difficult to fight.

    " We've known for some time that sulforaphane had modest antibiotic activity," says Jed Fahey, a plant physiologist at Hopkins. "However, its potency against Helicobacter, even those strains resistant to conventional antibiotics, was a pleasant surprise."

    Looking for Mr. Good Diet

    For the biggest bang for your antioxidant buck, combine antioxidants with good lifestyle habits. A laboratory study of the heart-healthy effects of taking supplements of the antioxidant vitamins C and natural E along with L-arginine (an amino acid) found that exercise magnifies benefits (Proceedings of the National Academy of Sciences 5/24/04, online). The scientists who performed this study recommend exercise along with antioxidants to boost your nutritional advantage.

    The box score shows that when playing with the A Team you've got the best chance of hitting an antioxidant home run.



    --
    Vitanet ®

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    Marilu Henner: Energy Personified!
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    Date: June 14, 2005 11:50 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Marilu Henner: Energy Personified!

    Marilu Henner: Energy Personified! by Stephen Hanks Energy Times, January 3, 2005

    Marilu Henner is an actress, dancer and author, a health, fitness and cooking guru and a devoted mom. Now she's also an advocate for nutritional supplements. In this revealing interview, she offers her thoughts on the battle to support consumer rights and to create a better health care system in America.

    "So, you want to know what my schedule is after I finish talking with you?" Marilu Henner says, in an almost breathless voice. "Today's Tuesday, right? Tomorrow morning I leave Los Angeles [where she lives] for New York City so I can do the Tony Danza Show first thing Thursday morning, Then, I take a 9 am flight back to LA because my son has a sleepover birthday party. I have a 7 am flight to New Jersey the next morning because I'm speaking about mental health at a conference at a big country club. The next morning, I catch a 7 am flight back to LA for my son's soccer games, one at noon and the other at 2. Whew!"

    Trying to keep up with Marilu Henner would make anybody feel out of breath because the woman is energy personified. At 52, her schedule includes acting in movies, on television and in the occasional Broadway show, writing books (she's authored seven, including Total Health Makeover and Healthy Life Kitchen), teaching online diet and exercise classes through her website (marilu.com), taking Pilates classes three times a week and raising two sons, Nicholas (10) and Joseph (8).

    But now, on top of all that, the former star of the TV show Taxi has become a health and nutrition activist, speaking out in favor of the use of dietary supplements whenever she can. This past September, Henner testified at a hearing of the House Subcommittee for Human Rights and Wellness to advocate increased funding for research and full implementation of the Dietary Supplement Health and Education Act (DSHEA). During her testimony, Marilu described why she believes consumers should have access to more information about supplements and why the products should be made more accessible through both government initiatives and private health plans. "I believe that dietary supplements should be part of a campaign to improve our nation's health," Henner testified.

    Energy Times recently caught up with Marilu at her Los Angeles home for a freewheeling conversation. Here, this vibrant yet down-to-earth celebrity displays her passion for health, nutrition and consumer issues.

    Energy Times: You've become one of the most high profile celebrities to advocate a consumer's use of dietary supplements. What was your motivation to get involved in such a public way?

    Marilu Henner: As a teenager, I had been a yo-yo dieter. I could be around 135 pounds and balloon up to 174. I knew I needed a different way of looking at my life. I couldn't concentrate on those stupid diets where I could lose 20 pounds in a week and then gain it all back over a weekend. But after my mom died at 58 in 1978, I said to myself, "It's not really about my body anymore, it's really about my health." I just became obsessed with health. I read everything I could get my hands on. I starting taking human anatomy classes, going to medical libraries and seeing nutritionists and doctors. And I started experimenting on myself, turning myself into my own guinea pig. It took me about eight years to put together a program. I always say that my health birthday was 1979, but it wasn't until 1987 that I could say I was living a completely healthy lifestyle.

    ET: Were you ever really heavy when you were performing in a show? MH: Sure. When I first performed the role of Marty in "Grease" more than 30 years ago I weighed about 175 pounds. But I hid it well. When you wear those 1950s clothes you can get away with it.

    ET: When did you start incorporating supplements into your health program? MH: Before I became pregnant with my first son in 1993, I had never been a supplement taker. But I started taking prenatal vitamins and dietary supplements when I was breastfeeding and they made me feel really good. After the pregnancy, I just kept taking them because I was getting the essential nutrients that I couldn't get from food alone. I was getting great stuff from my food, but with all the travel I do-you know, the eating on planes and in restaurants-I couldn't always shop for organic food. I had a doctor who understood the value of dietary supplements and encouraged me to use them. I've taken them ever since and I recommend them to my family and friends, as well as to people through my books and classes.

    ET: What supplements other than vitamins do you find helpful in your total nutrition program? MH: I take vitamin E, omega-3 fish oils, antioxidants, garlic, coral calcium and echinacea supplements.

    ET: So let's get back to why you decided to testify before Congress in support of supplement use. MH: I know that as soon as you put a celebrity face on an issue, people tend to pay a little more attention. When I was in Washington, I was able to tell Congress the personal stories I've heard about people who turned their lives around-from debilitating illness to vibrant health-when they got the information they need to make good choices. By good choices, I mean rejecting the manufactured foods of our society, with their over-reliance on sugar, meat and dairy, and the chemicals, hormones and steroids that usually accompany these products. Instead, we should be moving towards an organic, vegan diet that produces a sense of physical health. I also believe that a healthy diet includes the use of appropriate dietary supplements.

    ET: Do you think that government is moving fast enough to reduce the restrictions on safe supplements? MH: Things could always move faster. But I remember years ago writing letters on behalf of people who wanted supplements without needing a prescription. When I would tell people about the benefits of soy products or supplements, they'd think I was nuts. Now those ideas are mainstream. The floodgates are open and people want to know more. You can't even keep up with all the information. I think that the government knows they're not going to get away with making people have a prescription to take their vitamins.

    ET: What is the citizen's responsibility in all this? MH: We're in a real transitional phase and people should take responsibility to educate themselves. You have to question your doctors and recognize when something is or isn't working. You have to find a health practitioner who really knows their stuff.

    ET: As you said, there's so much information out there, how do you decipher it all? How can someone be an educated information consumer?

    MH: I know it's very difficult because there are so many options. Believe me, I've been doing this a long time and I'm glad I did the research. I think you have to read everything. You have to find a nutritionist/herbalist/doctor who's the real deal and knows what they're talking about. You have to recognize the symptoms in your own body and try to figure it out. I think if you start out with a good multivitamin, a calcium supplement, fish oils and vitamin E, that can be your base and you can't go wrong.

    ET: Isn't a diet built on buying organic foods much more expensive? MH: Sure, it's a little more expensive. But there's nothing more expensive than bad health. There's nothing more expensive than food being thrown away because it doesn't taste right. Organic fruit tastes so much better than the perfect-looking fruits and vegetables sprayed with pesticides.

    ET: What's your advice to people who want to start a workout and weight-loss program? MH: I'm always saying to people, "Look, you walk your dog, your cat stretches, your hamster runs on a hamster wheel. You're an animal, too, so go move, go do something." I know a lot of people believe that when you want to lose weight you have to go on these 1,200-calorie-per-day diets.

    Well, my weight is always between 120-124 pounds and I eat close to 2,000 calories a day, but everything I eat is of quality. And I burn a lot of calories because I wear comfortable shoes and I move around in my life. I'm always strong, I never get sick and I feel like an animal.

    ET: How do you view the future of healthcare policy in this country and where do you think nutritional supplements fit in? MH: I strongly believe that the general public needs more access to dietary supplements to maintain essential good health. American research and development has come up with really great products, but the American Medical Association and the drug companies have stigmatized supplements. So what's the result? Most Americans don't have access to safe supplements because they are not covered by their health plans, nor recognized as effective by the federal government. This really needs to be changed.

    I think we should take 90% of what we're spending on drugs that barely keep people alive and start spending it on prevention, nutrition and changing lifestyle habits. In this country we're all about curing the disease rather than curing the patient. We don't look at the patient holistically and try to find out how the disease developed. Your doctor should be in charge of keeping you well, not keeping you in that strange state of, what I call, "dis-ease." It's like the medical and pharmaceutical establishment wants to keep you just sick enough so you'll continue to be a paying customer. They've convinced people to think they've got to take a pill to cure themselves rather than use their own bodies.

    ET: Do you think medical schools will start training doctors to treat patients holistically and focus more on preventative medicine?

    MH: I think we're seeing a lot more nutrition and alternative medicine specialists these days. And the general public is becoming more aware of health and nutrition issues then they were years ago. There's this groundswell of people saying "Wait, I need more information. Wait, my doctor's no longer God. I can't just keep taking these pills and trying to figure out all these warning labels and side effects."

    ET: Do you plan on becoming more politically active on these issues? MH: Absolutely, I want to work with any organization that wants to improve school lunch programs, improve the healthcare system and get people more involved in understanding nutrition and disease prevention.



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    Your Healthy Harvest
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    Date: June 14, 2005 11:05 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Your Healthy Harvest

    Your Healthy Harvest by Marjorie Flakowitz Energy Times, August 15, 2004

    Once frowned on by conventional farmers, organic food has won respect from everyone concerned about the health of both the earth and the people who inhabit it.

    Today, organic farming is considered one of the most rapidly growing areas of American agriculture. Organic foods sales topped $9 billion in 2002 and grew about 20%, up to almost $11 billion in 2003 (Organic Trade Association).

    So when you buy organic, you join an expanding market that takes advantage of great-tasting, good-for-you food. Long ago, when the practice of farming was first devised, all farming was organic farming. So today's organic movement is bringing farming back to its roots.

    But, safe to say, that is not what's motivating most consumers. A main reason for the popularity of organic food derives from the reassurance that organic foods, raised without artificial chemicals and pesticides, cut your exposure to toxic residues. A growing body of research shows organic food is richer in beneficial natural substances, too.

    " Organic food and organic farming represent a philosophy that goes beyond just the quality of the food," says Steve Meyerowitz in The Organic Food Guide (Globe Pequot). "It strives to maintain the integrity of the entire food chain-plants, soil, air, water, animals and people. We are all part of the same ecosystem."

    By eating organic, you eliminate pollution both from your body and the earth. Because our bodies are made of the animal and plant products we consume, our internal, physiological ecosystem and the earth's environment are inexorably entwined.

    Chilling Arctic Evidence

    As evidence of this connection, consider what's happened in the Arctic. Researchers who have analyzed Arctic water, ice, snow, soil and plants have found that chemicals used in farming and industry in other parts of the world have traveled north and accumulated in alarming quantity. How and if these chemicals break down depends on sunlight and the amount of organic matter contained in Arctic waters (American Chemical Society, 9/11/03).

    " Once pollutants enter the water column, their behavior is poorly understood-particularly the processes that govern their lifetime and concentrations," says Amanda Grannas, PhD, a researcher at Ohio State University. "Such pollutants are now being found in wildlife, from fish to seals to whales, and even in people living in the Arctic."

    Dr. Grannas and others looked at the pesticides lindane and hexachlorobenzene (HCB), two chemicals that have migrated to Arctic waters. Lindane is used by American farmers to treat seeds before they are planted. HCB, banned in the US in 1984, is still used in other countries to protect wheat from fungus.

    The scientists found that sunlight at the top of Arctic waterways can help break down some pesticides. At lower depths, however, cut off from the sun's rays, pesticides can remain largely intact. In this research, lindane proved to persist much more readily than HCB.

    " Lindane is one of the most persistent of pollutants," warns Dr. Grannas. "This could be because it's photochemically inert, whereas pollutants like HCB degrade relatively quickly. The main message is that pollutants can behave quite differently. These pollutants already affect local ecosystems, and could have repercussions for human health."

    Organics Means More Benefits

    Researchers are also finding that organic produce contains larger quantities of beneficial natural chemicals. For instance, one study (Journal of Agriculture and Food Chemistry 2/26/03) showed that berries and corn grown organically can have almost 60% more polyphenolics. Polyphenolics are antioxidants plants use for protection against disease and which are good for humans. Researchers believe that when crops are grown conventionally, protected by pesticides and herbicides, they produce fewer of these substances. " This really opens the door to more research in this area," says Alyson Mitchell, PhD, assistant professor of food science at University of California at Davis, who led the research.

    These scientists compared levels of total polyphenolics and vitamin C content in marionberries (a type of blackberry) and corn grown organically, sustainably or conventionally, and also looked at chemicals in strawberries grown either sustainably or conventionally. (Sustainable farming falls between the organic and conventional methods, and concentrates on farming that's self-sufficient-for example, feeding cows hay you've grown yourself, and then using the cows' manure to fertilize another crop.) They found that organic marionberries and corn had 50% to 58% more polyphenolics. The sustainably grown strawberries had 19% more polyphenolics. And all the organic produce contained more vitamin C.

    Self-Defense for Plants

    According to Dr. Mitchell, the organic crops contained the high levels of polyphenolics you'd expect to find in wild plants, suggesting that, on conventional farms, pesticides reduce the necessity for plants to make these protective, natural chemicals. " If an aphid is nibbling on a leaf, the plant produces phenolics to defend itself," she says. "[P]henolics guard the plant against these pests."

    Pesticides kill insects like aphids and thereby reduce the antioxidants produced by the plant. " This helps explain why the level of antioxidants is so much higher in organically grown food," Mitchell says. "By synthetically protecting the produce from these pests, we decrease their need to produce antioxidants. It suggests that maybe we are doing something to our food inadvertently.

    " We know [polyphenolics] are beneficial [to human health], but we don't know what types of polyphenolics are beneficial, or in what quantities," Dr. Mitchell notes. " Originally, the question was just really intriguing to me. I found that the higher level of antioxidants is enough to have a significant impact on health and nutrition, and it's definitely changed the way I think about my food."

    Vitamin C in Oranges

    Meanwhile, nutritional research on the vitamin C in oranges turns up similar results: organic oranges are richer in this antioxidant nutrient than conventionally grown oranges (Great Lakes Regional Meeting, American Chemical Society, 6/2/02).

    The more common supermarket oranges are significantly larger than organically grown oranges, and they have a deeper orange color. Because of their larger size, "we were expecting twice as much vitamin C in the conventional oranges," says Theo Clark, PhD, chemistry professor at Truman State University in Kirksville, Missouri.

    But when he isolated the chemicals in the oranges and further refined his search with nuclear magnetic resonance (NMR), spectroscopy demonstrated that organically grown oranges possess 30% more vitamin C than the conventionally grown fruits-even though they are only about half as large.

    Dr. Clark isn't sure why organic oranges are richer in vitamin C, but he says, "...[W]e speculate that with conventional oranges, [farmers] use nitrogen fertilizers that cause an uptake of more water, so it sort of dilutes the orange. You get a great big orange but it is full of water and does not have as much nutritional value.

    " However, we can only speculate. Other factors such as maturity, climate, processing factors, packaging and storage conditions require consideration." Along with analyzing oranges, Dr. Clark and his research team questioned about 70 people to measure their concept of the nutritional value of organic oranges. In this survey, 85% of the respondents thought that organic oranges have a higher nutritional content than conventionally grown fruit.

    Dr. Clark's laboratory work shows that "they were right on." In Dr. Clark's view, these issues are important because consumers have a right to know the real nutritional content of organic produce, and the fact that analyses show that organic fruit has much more vitamin C validates the benefits of eating organic.

    Defense Mechanism

    Both plants and animals protect themselves from disease with many of the same chemicals. The natural substances that, in a farmer's field, defend vegetables from insects and microbes before they are harvested for your dinner go to work defending your body after you eat and digest them.

    When you eat organic you bolster your health with more of these natural wonders. No wonder organic is becoming so popular!



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    Fats for Life - the quality of the fat you eat is probably much more important than the...
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    Date: June 12, 2005 02:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fats for Life - the quality of the fat you eat is probably much more important than the...

    Fats for Life by Henry Wolfe Energy Times, August 6, 2003

    For years, many experts argued that the only good fatty foods were the ones you didn't eat. That was a big, fat mistake. Overwhelming evidence now shows that certain fats are not only necessary for optimal health, but that the quality of the fat you eat is probably much more important than the quantity.

    Threatening Trans Fats

    "The biggest thing wrong with the fats Americans eat today is that they are eating too many trans fatty acids," says Fred Pescatore, MD, author of The Allergy and Asthma Cure (John Wiley). "About 42,000 foods contain trans fats. These fats are linked to a higher risk of heart disease, stroke and cancer."

    Trans fatty acids are fats that form when food manufacturers add hydrogen to fat molecules, a process called hydrogenation that makes fats stay fresh longer without growing rancid. Trans fats also form when foods are fried.

    Hydrogenation extends the shelf life of refined foods like cakes, donuts, and crackers. Unfortunately, it also creates fats that many experts believe can compromise your health. In a study of the health effects of trans fats, 26 people agreed to eat a diet that changed every five weeks, continually shifting the types of fats in their meals (American Heart Association's Scientific Sessions 2000). All of the diets in the study provided 30% of calories from fat. One fifth of the fat came from either soybean oil, semi-liquid margarine, tub margarine, shortening, stick margarine or butter.

    "We were interested in assessing what would happen when we substituted one fat for another," notes researcher Alice H. Lichtenstein, DSc, professor of human nutrition at Tufts University, Boston.

    The study showed that as people ate more trans fatty acids (in the more solid margarines) and fewer polyunsaturated fats (in the liquid oils), their triglycerides increased after each meal. Triglycerides are blood fats that boost heart disease risk.

    For instance, when these folks ate stick margarine, which is high in trans fats, their triglycerides climbed an average 18% higher than when they ate semi-liquid squeeze bottle margarine, a type of margarine that is softer because it is less hydrogenated. Stick margarine raised heart disease risk by causing a drop in HDL, or "good" cholesterol. Although butter increased HDL, it also caused a significant increase in LDL, the "bad" cholesterol that raises heart disease risk.

    Dietary Advice

    "The best dietary advice we can give people is to minimize their intake of animal and hydrogenated fats in order to reach the American Heart Association's target of 10% or less of total calories from saturated fat and trans fatty acids," Dr. Lichtenstein says. "That would mean consumers choosing low-fat and non-fat dairy products and lean cuts of meat, and the food industry decreasing the amount of hydrogenated fats used in their products." According to a study at Johns Hopkins University (Amer Coll of Card, 52nd Scientific Session, 3/30/03, Chicago), people who eat saturated fat have more visceral fat, fat surrounding their internal organs. This fat around the waist is now seen as a risk factor for heart disease and other illnesses.

    Another hidden problem in our fat consumption, according to Dr. Pescatore, hides within canola oil. Dr. Pescatore says that although many consumers believe canola oil is beneficial to health, the refined canola oil sold in the US has had its potential health benefits removed during processing.

    "People still think canola oil is healthy and eat too much of it," he says. "The problem with canola is that it is highly processed and refined....Processors hydrogenate canola oil to keep it from getting rancid."

    According to Fred Ottoboni, PhD, coauthor of The Modern Nutritional Diseases (Vincente Books), "Canola oil is lightly hydrogenated to take out the omega-3 fatty acids (the healthiest, but most unstable, fats) and then the food manufacturers filter the trans fats out. I don't worry about the trans fats in canola, but the problem is the huge ratio of omega-6 fatty acids to omega-3s."

    To get more of the omega-3 fatty acids, which are lacking in most Americans' diets, Dr. Pescatore advocates using macadamia nut oil. "Macadamia nut oil is higher in monounsaturated fats than olive oil; it is the healthiest fat with an omega-3 to -6 ratio of one to one."

    The Omega-3 Difference

    Omega-3 and omega-6 fatty acids are basic forms of fat found in oils. Fish oil, hempseed and flax oil are high in what are called omega-3s. Certain plant-derived oils like corn and soy are richer in omega-6 fatty acids.

    "Primitive humans ate a diet that contained a one-to-one ratio of omega-3s and omega-6s," says Dr. Pescatore. "Today we (Americans) eat 20 times more omega-6 than -3; that's why we suffer so much chronic disease and chronic inflammation. For instance, the Japanese eat a (much better) diet that contains a two-to-one ratio of omega-6 fatty acids to omega-3." "Not all omega-6s are bad," he adds, "we just eat too many of them."

    Switching to healthier fat isn't hard. Eat more fish. When cooking, stick to oils like olive oil and macadamia oil. The quality of your oil and your health may improve in a big, fat way.



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    Energy Cycles - Stress and lack of energy don't just frazzle your nerves
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    Date: June 12, 2005 02:09 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Energy Cycles - Stress and lack of energy don't just frazzle your nerves

    Energy Cycles by Sylvia Whitefeather Energy Times, August 2, 2003

    Feeling stressed out and exhausted from an overburdened schedule? Regenerating your personal energy necessitates defusing stress. Stress and lack of energy don't just frazzle your nerves; they can leave you depressed, anxious and vulnerable to a long list of health problems.

    According to J. Douglas Bremner, MD, a psychiatrist at Emory University, Atlanta, when your brain overcharges on prolonged stress, your body pays a heavy, tiring price.

    "If stress has effects on the brain and neurological function, then stress has effects on all parts of the body, including the heart, blood vessels, immune system and digestive system," says Dr. Bremner, author of Does Stress Damage the Brain? (Norton). "The long list of damaging effects can include heart disease, memory impairment, depression and even increased susceptibility to stroke and cancer."

    A Good Night's Sleep

    Although getting a good night's sleep is a basic part of lowering stress and boosting energy, many of us seem to be tossing and turning through an epidemic of insomnia. The fact that so many people appear to suffer from disturbed and unsatisfying sleep may signal not only a personal energy lack, but also a deeper health crisis developing on the horizon. Lack of sleep, along with stress, not only contributes to those lackluster afternoons of the blahs, but it can also derail your basic body rhythms, weaken your immune system and make you age quicker.

    Researchers at the University of Chicago report that lack of sleep may deplete your get-up-and-go by upsetting basic metabolic functions and interfering with hormones. Pretty serious stuff: When people in this experiment cut back their sleep time to about four hours each night, their bodies behaved as if they were twenty years older and they started showing signs of developing diabetes. These effects happened in only a week of missing sleep (The Lancet, October 23, 1999).

    The drastically reduced sleep schedule slowed the thyroid gland, reducing the production and action of thyroid hormones. As a result, metabolism slowed and the non-sleepers developed that awful sluggish feeling too many of us know and hate.

    Stress from lack of sleep also coaxed the adrenal glands into releasing extra amounts of cortisol, a stress hormone whose purpose is to force the body into providing short-lived energy boosts. But after a while the body flames out, its ability to cope with daily demands drained even further.

    "We found that the metabolic and endocrine changes resulting from a significant sleep debt mimic many of the hallmarks of aging," says Eve Van Couter, PhD, professor of medicine at the University of Chicago and director of the study. "We suspect that chronic sleep loss may not only hasten the onset but could also increase the severity of age-related ailments such as diabetes, hypertension, obesity and memory loss."

    And when are you are constantly short-changed of sleep, it builds up an accumulative effect. Particularly susceptible are busy parents, shift workers, menopausal women and college students.

    One way to take back your energy from this metabolic madness is to get twelve hours of sleep a night for a week. But aside from hitting the snooze button a few hundred times, a possible antidote to this cortisol nightmare may be vitamin C.

    Fight and Flight

    The human body, which evolved before the advent of split-level houses and SUVs, was built to survive life-threatening, physical danger. When it encounters modern-day stress, such as traffic jams and credit card bills, it releases extra cortisol, heightening the body's immediate ability to run or fight. As a result of cortisol release, senses go on high alert, heart rate speeds up, blood flow to muscles increases, and the immune system mobilizes to deal with what it thinks is an imminent crisis.

    However, unlike physical danger that rapidly resolves (either you get away from what's trying to harm you or it does you in), today's stress drags on and on (at least till the next exit on the expressway), and the cortisol in the body continues to circulate.

    The long-range result of persistent cortisol is a drop in energy, rampant fatigue and lowered immunity. You feel constantly tired and you get sick more often. You may also gain weight.

    But researchers at the University of Alabama at Huntsville have found that large doses of vitamin C "reduce...the levels of stress hormones in the blood and also reduce...other typical indicators of physical and emotional stress, such as loss in body weight, enlargement of the adrenal glands, and reduction in the size of the thymus gland and the spleen," according to P. Samuel Campbell, PhD (American Chemical Society, 1999). Dr. Campbell believes that our prehistoric ancestors probably consumed large amounts of vitamin C in a tropical diet rich in fruits. "If so, the physiological constitution we have inherited may require doses far larger than the present RDA (the amount the government recommends) to keep us healthy under varying environmental conditions, including stress."

    Iron Out the Fatigue

    If you are a premenopausal woman, a lack of iron may also be draining your body of energy. According to experts, as many as one of every five women who menstruate may suffer anemia caused by a lack of iron. This type of problem is also frequent in teenagers and during pregnancy. (But before you take iron supplements, talk to your health practitioner to make sure this is the source of your fatigue.)

    "Women with heavy menstrual flow have the greatest risk (of anemia)," points out Susan Lark, MD, in Healing with Vitamins (Rodale). Dr. Lark recommends eating more iron-rich foods (like organic red meat) even if you are not anemic, since a mild iron deficiency can drag you down into the doldrums.

    Vegetarians necessarily eat fewer iron-rich foods than do meat eaters. But if you take a vitamin C supplement when you consume such iron-rich vegetables as lima beans, pinto beans and spinach, your body can absorb more of the iron in these foods.

    The Krebs Cycle: Keep the Wheel Turning

    All of your cells make the energy that keeps you going. This process, a complicated chemical reaction called the Krebs cycle, transforms fatty acids and carbohydrates into ATP (adenosine triphosphate) for cellular energy. Mitochondria, small structures in each cell, are the centers of this energy production.

    Energy production requires oxygen. The more oxygen available to the cells, the more energy is produced. Deep breathing and moderate exercise are simple, quick ways to oxygenate the body and boost energy. That is why walking, jogging and other physical activity wakes up your brain and restores pep.

    If you've been looking for ways to feel more energetic, take a deep breath and go for a long walk before you sit down to your rejuvenating lima beans and vitamin C. And another thing...take a pass on those late-night TV shows. Sleep is more important.



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    The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
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    Date: June 09, 2005 05:22 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

    The Latest Breakthroughs in Garlic Research

    on Cancer and Cardiovascular Disease

    Presented at the 2005 World Garlic Symposium

    Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

    “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

    Presentation highlights included:

  • • Clinical Intervention Trial and pre-clinical substantiation on Cancer using Garlic, presented by National Cancer Institute scientists, Mitchell Gail and John Milner Mounting evidence points to the anticancer properties of aged garlic extract and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis.

  • • Inhibition of Coronary Arterial Plaque Accumulation by Garlic, presented by Matthew Budoff, Harbor-UCLA Medical Center

    Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.

  • • Influence of Garlic on Endothelial Dysfunction in Hyperhomocysteinemia, presented by Norbert Weiss, University of Munich in Germany Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute high homocysteine on endothelium-dependent brachial artery vasodilatation and on acetylcholine-induced stimulation of skin perfusion.

  • • Anti-glycation properties of aged garlic extract: possible role in prevention of diabetic complications, presented by Nessar Ahmed, Manchester Metropolitan University in England Aged garlic extract inhibited the formation of advanced glycation end products, which have been previously shown to increase the risk of diabetic complications ranging from heart disease to retinopathy, kidney failure, impaired wound healing and many more.

    “Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

    Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

    Abstracts

    PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

    Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

    INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

    Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

    INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

    Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

    Bibliographies

    David Heber, MD, PhD, FACP, FACN

    Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

    Matthew Budoff, MD, FACC

    Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.



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    Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids
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    Date: June 09, 2005 09:35 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids

    Essential Fatty Acids and Phospholipids

    Essential fatty acids & phospholipids are primary constituents of cell membranes, and as such they are vital to the makeup of the human body. Essential fatty acids are used to generate certain intra-cellular hormone-like substances, including prostaglandins and leukotrienes, which are responsible for regulating key bodily processes. Source Naturals essential fatty acid supplements are potent, effective and chemical-free.

    LIPIDS, CELL MEMBRANES & EICOSANOIDS

    Almost by definition, life is composed of cells, and cells are defined by membranes. One theory suggests that, around four billion years ago, self-replicating molecules, similar to the ribonucleic acid or RNA in our own cells, were synthesized from organic molecules. These self-replicating molecules adapted to changes in their environment to increase their potential for survival. Thus began the process of evolution that has led, over the eons, to us. One turning point was when these molecules developed membranes - envelopes which could help concentrate chemicals needed for the cell's survival. There existed in the "primordial soup" substances uniquely suited to this purpose: a class of organic compounds we call lipids . Lipids are more commonly called fats, and in this health and image-conscious age people often think of them as something to be avoided. However, the word fat refers to a variety of substances with a diverse range of chemical properties, which are essential for survival and well-being . The simplest lipids, fatty acids such as palmitic acid, consist of a hydrocarbon "tail" connected to a carboxyl group (COOH). The majority of lipids in food and in the human body occur in the form of triglycerides - a molecular configuration in which three fatty acid chains are attached to a 'backbone' of glycerol (an organic alcohol composed of a 3-carbon chain with an alcohol group attached to each carbon). The major roles of lipids can be described as energy and storage, structural, and metabolic.

    Energy and Storage

    Molecules can contain more or less chemical energy. In living systems most of the energy needed to drive chemical reactions is derived from oxidation. Oxygen, the ultimate electron acceptor, is a strong oxidant: it has a marked tendency to attract electrons, becoming reduced in the process. When a molecule undergoes a chemical reaction from a high-energy reduced state to a low-energy oxidized state, energy is released. This is what happens in a fire: the high-energy carbohydrates in wood, such as glucose, react with oxygen, releasing heat and the low-energy molecules of carbon dioxide and water. This is similar to what happens in metabolism.

    Most of the carbon in a fatty acid chain is highly reduced, which makes fats more energy-rich than the other organic molecules that can be burned as food. This is what we mean when we say fats are high in calories - a measure of the amount of energy released when a substance is oxidized. Fats contain more than twice as many calories as carbohydrates. This makes fats an important storage fuel for most of the body.

    Structure

    Another important class of lipids in the human body consists of the phospholipids. Like triglycerides, phospholipids contain fatty acid chains- in this case two, one saturated and one unsaturated, attached to a glycerol backbone. Unlike triglycerides, in phospholipids the third carbon of the glycerol molecule is attached to a phosphate (a molecular group that contains phosphorus and oxygen), which is in turn attached to either an amino acid or, in the case of phosphatidyl choline, a molecule of the B-vitamin - like substance, choline.

    Their unique molecular structure makes phospholipids amphipathic, which means 'likes both':

  • The phosphate-containing head group is strongly dipolar (it has positive and negative charges and can mix with water, and thus is hydrophilic, which means 'water-loving').

  • The two fatty acid chains make up a long tail group which is nonpolar (it has no charge and cannot mix with water, and thus is hydrophobic, which means 'water-hating').

    Fats, being hydrophobic, tend to separate out from water. When fat is mixed with phospholipids in the presence of water, the phospholipid molecules attach themselves to the molecules of fat and bring them into the water solution, enabling the fats to dissolve in water.

    Phospholipids form a structure called a lipid bilayer, a two-ply sheet of phospholipid molecules in which the hydrophilic head groups face outward and are in contact with the water, and the hydrophobic tails face each other on the inside of the bilayer. This structure is one of the key constituents of the cell membranes that surround every living cell.

    The lipid bilayer of cell membranes is a fluid in which membrane-embedded proteins "float." These proteins serve a wide variety of different functions. Some are enzymes, serving to carry out chemical reactions in the adjacent solution. Some are involved in signaling, in which a biochemical action in a cell is 'commanded' by means of a hormone or some such other signaling molecule. Still others are involved in transporting substances across the membrane, into or out of the cell.

    The functions of membrane-embedded proteins are dependent on a very precise balance of phospholipids for their function. Phosphatidyl serine, for instance, has a negatively-charged head group that associates preferentially with a class of membrane-bound proteins called ATPases. ATPases regulate, among other things, the balance of sodium and potassium in intra- and extracellular fluids, a balance that is necessary for the integrity of our cells and also for the electrochemical impulses that make up our thoughts and feelings. Without phosphatidyl serine, these vitally important membrane-embedded proteins could not function.

    Cholesterol is a waxy substance that is essential to the structure of cell membranes, which depend for their function on a delicate balance between fluidity and solidity. Cholesterol provides a semifluid matrix, as well as enhancing membrane fluidity. About 80% of the cholesterol the body uses is manufactured by the liver; the other 20% is consumed in food. Elevated blood cholesterol levels are associated with heart disease. Saturated fats are converted into cholesterol more readily than unsaturated fats, and polyunsaturated fats usually depress blood cholesterol concentration to some degree. Researchers have thus recommended that people lower their consumption of saturated fats and increase their consumption of polyunsaturated fats. A process called hydrogenation , in which hydrogen molecules are added, is used to harden these unsaturated fats to create solid spreads, such as margarine. This process causes formation of altered fats called trans fatty acids. Although the results are not conclusive, human and animal studies have pointed to possible deleterious effects from consumption of trans - fatty acids, which are estimated to account for 5.5% of all fats consumed by Americans. These studies include one in men and women that showed harmful effects of trans - fatty acids on blood cholesterol ratios.

    Metabolic

    When each link of a fatty acid chain contains an atom of hydrogen, as in palmitic acid, that fatty acid is said to be saturated . If two carbon links are double bonded to each other, each has one less hydrogen atom, and the fatty acid chain is said to be unsaturated. If a fatty acid contains one double bond, it is said to be monounsaturated, and if it has two or more double bonds it is said to be polyunsaturated . Certain polyunsaturated fatty acids cannot be manufactured by the body and must be obtained from the diet. These nutrients are called essential fatty acids and are necessary for the normal function of all tissues. The essential fatty acids fall into two categories:

  • (1) Those with an unsaturated double bond between the 6th and 7th carbon in the chain, called omega-6 fatty acids, which include linoleic acid (LA), gamma-linolenic acid (GLA), and arachidonic acid (AA).

  • (2) Those with a double bond between the 3rd and 4th carbons, called omega-3 fatty acids, which include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

    In addition to being phospholipid precursors, essential fatty acids can be converted to a class of hormone like intracellular messengers called eicosanoids. The physiologic effects of eicosanoids are potent in minute quantities. Their effects are so powerful that they need to be produced near the site of their action and are quickly inactivated. The important eicosanoids include the thromboxanes, leukotrienes and prostaglandins (PGs ). Prostaglandin molecules consist of a five-carbon ring with two side chains. They can be distinguished from each other by numbers that refer to the number of double bonds in their molecular side chains: 1-series PGs have one double bond, 2-series have two double bonds, and so on. Prostaglandins mediate a variety of bodily processes, including inflammatory reactions, blood vessel contraction and dilation, and platelet aggregation. The different PGs have different effects on the body, and different essential fatty acids act as precursors for different PGs.

    Important essential fatty acids in humans are the omega-6 fatty acids, which include linoleic acid (LA), gamma-linolenic acid (GLA), and arachidonic acid (AA). 1-series PGs are derived from GLA and tend to cause blood vessels to dilate and reduce the stickiness of platelets (cell fragments in the blood that help initiate blood clotting). 2-series PGs are derived from arachidonic acid and tend to increase platelet stickiness and cause blood vessels to constrict. Meat and dairy products are dietary sources of the PG2 precursor, arachidonic acid; American diets tend to be rich in these foods. The rate-limiting step for production of GLA in the human body is an enzyme called delta-6-desaturase (D6D). The action of this important enzyme can be blocked by a number of different lifestyle factors, including a diet high in saturated or trans- fatty acids and chronic alcohol consumption. A modest increase in consumption of GLA will significantly increase the ratio of GLA to AA in the tissues, which may have a beneficial effect on the homeostasis of the cardiovascular system. Supplementation with omega-3 fatty acids, such as flaxseed oil or fish oil, is beneficial for similar reasons. Omega-3 fatty acids are precursors for 3-series PGs, which reduce platelet stickiness. Series-3 PGs also tend to inhibit conversion of AA into its metabolites, the 2-series PGs.

    The lipid composition of our diets has changed radically in the 20th century. Our intake of saturated fats has increased dramatically, and trans fatty acids, which did not exist before the advent of modern food processing technology, now form a major part of our diets. We eat less fish and green leafy vegetables, important sources of omega-3 fatty acids, than our ancestors did. Far from being an inert, homogeneous substance, fat is dynamic and varied - a subtle and interactive matrix for many of the biological processes taking place in our bodies, minute by minute.



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    PREGNENOLONE - The Balancing Hormone
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    Date: June 04, 2005 01:40 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: PREGNENOLONE - The Balancing Hormone

    Pregnenolone

    Hormones are potent regulators of the most intricate biochemical functions involved in our metabolism, growth, development, emotion and behavior. For our bodies to function properly, our hormones must be in balance with one another. But aging, stress and environmental factors can contribute to hormonal imbalances, with serious impact on our well-being. Today, science has rediscovered a beneficial hormone with the capacity to reduce stress, fatigue and support mental alertness. This hormone is broad – spectrum in its influences - with the ability to balance the levels of other hormones in our bodies. Unfortunately, our production of this hormone declines as we grow older - suggesting the desirability of supplementation. Introducing: Source Naturals PREGNENOLONE.

    A Wide Range of Beneficial Properties

    Pregnenolone - a hormone produced from cholesterol in our adrenal glands, liver, skin, testicles, ovaries, and brain - was the subject of intense interest in the 1940’s. Some of the earliest studies, performed by well-known researcher Hans Selye, found it to be helpful in reducing stress and fatigue. Additional studies were conducted throughout the decade, with positive results. Pregnenolone supplementation was found to benefit people who were under excessive stress. It also was reported to support joint and tissue function and to contribute to skin elasticity. Pregnenolone is believed to affect stress levels through its influence on the adrenal glands, which produce more steroid hormones when people are under stress. Pregnenolone may also affect brain chemistry in beneficial ways. It has been found to inhibit the GABA receptors in brain cells - which may result in increased mental alertness. It may also stimulate the NMDA (N-methyl-D-aspartate) receptors, which play an important role in regulating synapses, thus influencing learning and memory.

    Pregnenolone: The Unique Hormone

    Much of the current interest in pregnenolone is related to its role as “the grandmother of all steroid hormones.” Pregnenolone is the starting point from which all steroid hormones are manufactured in our bodies. As a “hormone balancer,” it has the capacity to increase the levels of steroid hormones that are deficient in our bodies and to reduce the levels of excess circulating hormones. Some scientists believe pregnenolone is converted into other hormones only as they are needed by our bodies. The conversion of pregnenolone follows different pathways, depending upon cellular requirements. Pregnenolone may be converted into DHEA (dehydroepiandrosterone), which in turn can be changed into androgens (including testosterone), estrogens and other steroids; or, it may be converted into any or all of a chain of hormones including progesterone, corticosterone, and aldosterone. These characteristics make pregnenolone unique. Because cells may only convert pregnenolone into other hormones on an “as needed” basis, pregnenolone may correct imbalances in the levels of some hormones, without affecting others. This is a great advantage over steroid hormones like DHEA, which may create excess estrogen and testosterone. Pregnenolone is also distinctive because of the innumerable bodily activities it can influence. As a steroid hormone precursor, it is believed to be involved in every biochemical action exhibited by any steroid hormone. This means it may impact memory, mental alertness, stress responses, female reproductive cycles, the body’s natural defenses, and joint and tissue function. With such a wide spectrum of involvement, the potential uses of pregnenolone could be boundless. Source Naturals PREGNENOLONE is available in 10 mg sublinguals and tablets, as well as in 25 mg tablets. All potencies are sold in 60 and 120 tablet bottles.

    References
    1. Akwa, Y., et al. J. Cell Biology, (1993). 121(1), 135-143. 2. Flood, J.F., et al. (1995, Apr.). Physiology and Behavior, 57(4), 669-73. 3. Flood, J.F., et al. (1995). Proc. Natl. Acad. Sci., 92, 10806-10810. 4. Flood, J.F., et al. (1992). Proc. Natl. Acad. Sci., 89, 1567-1571. 5. Henderson, E., et al. (1950). J Clin Endocrinology, 10, 455-474. 6. Hoagland H. (1944). Science, 100(2587), 63-67. 7. Jung-Testas, Z.Y., et al. (1989). Endocrinology, 125(4), 2083-2091. 8. Mayo, W., et al. (1993). Brain Research, 607, 324-328. 9. Pincus, G., et al. (1945). Psychosom. Med., 7, 347-352. 10. Pincus, G. & Hoagland, H. (1944, Apr.). Aviation Medicine, 98-115. 11. Pincus, G. & Hoagland, H. (1945). Psychosom. Med., 7, 342-346. 12. Roberts, E. (1995). Biochemical Pharmacology, 49(1), 1-16. 13. Roy, R., & Bélanger, A. (1992). Endocrinology, 131(3), 1390-1396.



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    Positive Thought - Balance Emotions and Mood...
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    Date: June 04, 2005 01:34 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Positive Thought - Balance Emotions and Mood...

    As modern life becomes increasingly stressful, people are seeking out natural products that promote calmness and relaxation. But unless your supplement addresses multiple body systems, a healthy positive outlook may be out of reach. POSITIVE THOUGHTS Bio-Aligned Formula supports the interrelated systems and functions involved with emotional balance: inhibitory, stimulating and balancing neurotransmitters, and energy metabolism. This comprehensive herbal-nutrient blend features St. John’s wort, which has been clinically shown to support a good mood.

    A Bio-Aligned Formula™

    POSITIVE THOUGHTS is designed to bring alignment to the multiple, interconnected systems that influence a positive mood. Here’s how:

    Neuro-Modulation—Inhibitory

    Neurotransmitters are brain chemicals that aid in the process of nerve cell communication. Inhibitory neurotransmitters, such as GABA, reduce brain stimulation, helping to support a sense of relaxation and calm. The nerve cell membrane- stabilizing properties of taurine also support relaxation, as do the included herbs. In addition to supplying GABA and taurine, POSITIVE THOUGHTS supports inhibitory neuro-modulation with kava, lemon balm, valerian, and vitamin B-6.

    Neuro-Modulation—Stimulating

    Stimulating neurotransmitters help promote drive, ambition, alert mental functioning, and memory. They support a positive mental outlook by providing a feeling of energy and vitality. POSITIVE THOUGHTS supports stimulating neuromodulation with DMAE, L-phenylalanine, L-tyrosine, N-acetyl-L-tyrosine, and vitamins B-5 and B-6.

    Neuro-Modulation—Balancing

    In our high-powered, stress-filled world, the balancing properties of St. John’s wort can help maintain a positive outlook and a sense of well-being. Studies have shown that St. John’s wort can help support a positive mood.

    Acetylcholine Production

    Acetylcholine is one of the most important neurotransmitters in the brain. It is vital for memory, cognitive function, focus, concentration, and muscle movement. POSITIVE THOUGHTS contains DMAE, vitamins B-1, B-5 and B-12, and pantothenic acid to support acetylcholine production.

    Energy Metabolism

    The brain’s energy supports the vast electric, chemical, and structural processes that are the basis of a positive outlook. The brain uses 60% of the glucose used by the body at rest. Nutrients help convert glucose to the energy that the brain requires. They are also a component of many coenzymes needed for the synthesis of key neurotransmitters. POSITIVE THOUGHTS addresses energy metabolism with these nutrients: magnesium, manganese, zinc, vitamins B-1, B-2, B- 3, B-5, B-6, B-12 and C, biotin, and folic acid.

    Strategies for WellnessSM: A Healthy Mood Plan

    Lifestyle choices can help you maintain a positive attitude in response to the normal stresses of everyday life.

  • • Simplify Your Life: Is it important to have a luxury car or a large house? If so, you will have to work long hours and worry about making ends meet. How important are all the activities in your busy schedule? Choose one or two you truly enjoy and reevaluate your commitment to the others.
  • • Eat Well: Anxiety drains your energy, so it is important to nourish your body in the face of stress. Eat fruits, vegetables, whole grains, and highprotein foods, and consider taking nutritional supplements. What you eat can influence your mood—keep track of which foods help or hinder you. Avoid excessive caffeine, alcohol and sugar, which raises energy in the short term but leads to depleted energy over time.
  • • Get Active: Exercise improves blood flow to your brain, and helps release “feel good” chemicals called endorphins into your blood stream. Physical activity also takes your mind off your troubles and helps you focus on things outside yourself.
  • • Meditate: This effective relaxation method can divert your mind from problems, give you time to recuperate, and help with clear thinking, focus and concentration. It also slows your breathing, allowing your lungs to fill with fresh oxygen—your body’s fuel—and to release waste products.
  • • Express Yourself: Keeping a journal is a great way to think about what upsets you and how it can be changed. Artistic expression—drawing, painting, or sculpting—may help reconcile inner conflicts and foster self-awareness. Dance or movement therapy may be your preferred mode of expression, especially for gaining a sense of ease with your body. Or music may help you relax or feel upbeat.
  • • Share Your Feelings: Develop supportive relationships—just talking to friends or family, even without finding solutions, can help you feel better. And you may get insights that help you articulate what you are struggling with. Know when to seek professional help if problem become overwhelming.

    Neuro-Modulation—Inhibitory: GABA, Kava Kava, Lemon Balm, Taurine, Valerian, Vitamin B-6

    Neuro-Modulation—Stimulating: DMAE, L-Phenylalanine, LTyrosine, N-Acetyl-L-Tyrosine, Vitamins B-5 & B-6

    Neuro-Modulation—Balancing: St. John’s Wort

    Acetylcholine Production: DMAE, Vitamins B-1, B-5 & B-12, Pantothenic Acid

    Energy Metabolism: Magnesium, Manganese, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6, B-12 & C, Biotin, Folic Acid

    References:
    Johnson, D. et al. (1994). J Geriatr Psychiatry Neurol:7 (suppl 1), S44-S46. Johnson, D. et al. (1992). TW Neurologie Psychiatrie:6, 436-444. Leathwood, P.D. et al. (1982). Pharmacology Biochemistry & Behavior:17, 65-71. Sabelli, H.C. (1986). J Clin Psychiatry:47(2), 66-70. Schulz, H. & Jobert, M. (1994). J Geriatr Psychiatry Neurol:7 (suppl 1), S39-S43. Wurtman, R.J. et al. (1974). Science:185, 183-184.



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    Heart Science - A Five-Tiered Approach to Heart Health ...
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    Date: June 02, 2005 12:07 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Heart Science - A Five-Tiered Approach to Heart Health ...

    Heart Science 30 tabs

    Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.

    Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health

    Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
    1) generating energy,
    2) decreasing harmful homocysteine levels,
    3) fighting oxidized cholesterol,
    4) maintaining the heart’s electrical rhythm, and
    5) protecting artery and capillary linings.

    Energy Generators for An Energetic Organ

    Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.

    There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.

    CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10

    Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.

    Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21

    HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.

    Homocysteine Regulators

    B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.

    The Dangers of Oxidized LDL Cholesterol

    While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.

    When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.

    The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.

    Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.

    Cholesterol Fighters

    Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:

  • • Beta Carotene, a plant pigment, is the naturally occurring precursor to Vitamin A. When the body takes in high enough amounts of Beta Carotene, this lipid-soluble free radical scavenger concentrates in circulating lipoproteins and atherosclerotic plaques, where it performs its antioxidant functions. Beta Carotene is particularly unique and powerful as an antioxidant because it is capable of trapping a very toxic form of di-oxygen, called singlet oxygen, which can result in severe tissue damage. Beta Carotene is one of the most efficient quenchers of singlet oxygen thus far discovered. Six tablets of HEART SCIENCE provide an unprecedented 45,000 IU of Beta Carotene!
  • • Vitamin C is found in plasma, the watery component of blood, where it functions as a potent antioxidant. In addition to strengthening artery linings through collagen manufacture, Vitamin C is involved in the regeneration of Vitamin E within LDL particles. Vitamin C also plays an important role in the conversion of cholesterol into bile acids by the liver, a crucial step in reducing blood cholesterol levels. Once converted into bile acids, and then into bile salts, cholesterol can be excreted from the body, preventing build-up. Supplementation with Vitamin C may lower levels of LDL cholesterol and increase those of HDL cholesterol.25 It may also have a part in actually removing cholesterol deposits from artery walls — good news for people who are already experiencing plaque buildup.25 Each daily dose of HEART SCIENCE provides 1,500 mg of Vitamin C in its bioactive mineral ascorbate form.
  • • Vitamin E, together with Beta Carotene, protects lipids from free radical attack. It is the major antioxidant vitamin that is carried in the lipid fraction of the LDL particle, where it protects the LDL particle from damaging oxidation. Within an LDL particle, one molecule of Vitamin E has the ability to protect about 200 molecules of polyunsaturated fatty acids from free radical damage! Vitamin E also aids in protecting the heart by interfering with the abnormal clumping of blood cell fragments, called platelets, within blood vessels.4 It has been shown to inhibit the formation of thromboxanes and increase the production of prostacyclins, which together decrease abnormal platelet aggregation.11 A high potency of Vitamin E — 400 IU’s — is included in six tablets of HEART SCIENCE in the natural d-alpha succinate form, recognized by scientific researchers to be the most absorbable form!
  • • Selenium is an important mineral which has only recently gained attention. When incorporated into the enzyme Glutathione Peroxidase, it has highly powerful free radical-scavenging abilities, and has been shown to work synergistically with Vitamins A, C, and E. An essential mineral, Selenium used to be derived from eating foods grown in Selenium-rich soil. However, modern agricultural practices have depleted soil of its natural Selenium content, leaving many Americans deficient in this vital nutrient. Several epidemiological studies show that the incidence of advanced fatty deposits in blood vessels is much greater in individuals living in geographic areas of the United States and other parts of the world where the Selenium content of the soil is very low.27
  • Proanthodyn,™ an extract of grape seeds, is being called the most powerful antioxidant yet discovered. This highly potent, water-soluble bioflavonoid contains between 93-95% proanthocyanidins, the highest concentration of any nutrient available today. The protective actions of proanthocyanidins may help to prevent the development of plaque in artery walls by inhibiting the free radicals which are produced during the oxidation of cholesterol. The optimal daily amount (100 mg) of Proanthodyn is included in six tablets of HEART SCIENCE. In addition to the protective actions of antioxidants, several other nutrients can contribute to healthier cholesterol ratios.
  • • Chromium is a trace mineral which functions to aid the entrance of glucose into cells. Six tablets of HEART SCIENCE provide 300 mcg of Chromium in the form of Chromate® Chromium Polynicotinate and Chromium Picolinate — the most bioactive forms of Chromium. Not many people are familiar with the vital role Copper plays in the body. This trace mineral is found in all tissues of the body, and is particularly concentrated in the heart. Copper is part of several enzymes, and, in this capacity, is necessary for the development and maintenance of the cardiovascular system, including the heart, arteries, and other blood vessels. Because of its role in elastin production, Copper deficiency can severely damage blood vessels and heart tissue. In fact, researchers have found an inverse relationship between Copper status and increased risk for heart damage.10
  • • L-Proline and L-Lysine are two natural amino acids which show exciting promise in helping to prevent fatty deposits in blood vessels. Researchers have recently identified a particle associated with LDL called apoprotein (a) which is believed to be a main culprit in plaque development. 17 Scientific investigation has revealed that the lipoprotein (a) particle has an adhesive quality that makes the lipoprotein fat globule stick inside blood vessels. The sticky fat globules accumulate, leading to fatty deposits in blood vessels and the subsequent clogging of the arteries. L-Proline and L-Lysine tend to form a barrierlike layer around the apoprotein (a) particle, helping to push it away from the blood vessel wall, and impeding deposit.21

    The Regulating Trio

    Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.

  • • Magnesium is one of the single most important nutrients for maintaining a healthy heart. It plays an extremely vital role in maintaining the electrical and physical integrity of the heart muscle. It has been well established that Magnesium deficiency predisposes humans to serious disruptions of normal cardiac rhythm. One theory is that because Magnesium has a relaxing effect on muscle tissue, inadequate Magnesium stores may make the coronary arteries more susceptible to muscle spasm.10 Too little Magnesium can cause a Calcium/Magnesium imbalance, which can lead to the influx of too much Calcium into heart cells, and potentiate spasms in heart tissue. Another point for consideration is that because it relaxes the blood vessels, Magnesium keeps these vessels open, allowing for maximum blood flow to the heart. Magnesium also has the unique ability to stop unnecessary blood clotting by helping to reduce platelet adhesion.31 Blood clots are naturally produced by the body as a protective device to stop excessive blood flow when the body is injured. The clotting response happens when the body senses that the normally smooth blood vessel linings are rough, indicating that there is a cut. However, sometimes the body mistakes the rough surface of plaque-covered arteries as cuts, and creates unnecessary blood clots. Or, if a high fat meal has just been eaten, tiny fat globules called chylomicrons enter the bloodstream and can cause platelets to become abnormally sticky, possibly creating clots. When these clots flow through the bloodstream and reach a part of the artery which has plaque buildup, normal blood flow is blocked, and the amount of blood which reaches the heart is severely compromised. Magnesium is also crucial for the entrance of Potassium — a key mineral for many bodily functions — into the cells. Even if the body’s Potassium stores are high, without enough Magnesium, the Potassium will not be able to enter the cells and be utilized by the body. 300 mg of Magnesium (75% of the U.S.RDA) are contained in each daily dose of HEART SCIENCE. Along with Magnesium, Potassium helps to regulate normal heartbeat and blood pressure, and is necessary for the contraction and relaxation of muscle tissue. Potassium and Sodium are present in all body fluids; Potassium is found primarily within cell fluids, while Sodium is usually present in fluids surrounding cells. Together, they function to maintain the normal balance and distribution of fluids throughout the body. The body ideally should have a Potassium/Sodium balance of about 1:1; however, because the body holds onto Sodium, yet eliminates Potassium quickly, it is important that the dietary ratio of these two minerals be at least 3:1. Unfortunately, the typical American diet, with its emphasis on processed, salty (Sodiumrich) foods and lack of fresh fruits and vegetables, severely alters the body’s natural Potassium/ Sodium balance. Diets in the United States are extremely high in Sodium — sometimes containing as much as 15 times the recommended daily intake! A high Sodium/low Potassium diet interferes with the normal regulation of heartbeat and blood pressure, and has been linked with elevated blood pressure.25 Taurine is an amino acid which helps normalize electrical and mechanical activity of the heart muscle by regulating Potassium flux in and out of the heart muscle cells.

    Artery Lining Protectors

    Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6

    Capillary Strengtheners

    Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.

    Heart Smarts

    The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.

    Source Naturals HEART SCIENCE™


    The Five Tiered Approach to Heart Health
    Six tablets contain:
    Vitamins and Minerals %USRDA
    Pro-Vit A (Beta Carotene) 45,000 IU 900%
    Vit B1 (Thiamine) 50 mg 3333%
    Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
    Vit B6 (Pyridoxine HCl) 25 mg 1250%
    Coenzyme B6 (Pyridoxal-5-Phosphate)
    25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
    Vit B12 (Cyanocobalamin) 500 mcg 8333%
    Folic Acid 800 mcg 200%
    Vit C (Magnesium Ascorbate) 1500 mg 2500%
    Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
    Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
    Copper (Sebacate) 750 mcg 37.5%
    Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
    Potassium (Citrate) 99 mg *
    Selenium (L-Selenomethionine) 200 mcg *
    Silicon (From 400 mg of Horsetail Extract) 13mg *
    * U.S. RDA not established.
    Other Ingredients and Herbs
    Coenzyme Q10 (Ubiquinone) 60 mg
    L-Carnitine (L-Tartrate) 500 mg
    Hawthorn Berry Extract 400 mg
    Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
    L-Proline 500 mg
    L-Lysine (HCl) 500 mg
    NAG™ (N-Acetyl Glucosamine) 500 mg
    Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
    Taurine (Magnesium Taurinate) 500 mg
    Horsetail Extract (Yielding 31 mg of Silica) 400 mg
    Inositol (Hexanicotinate) 50 mg

    Reference:
    1. Azuma, J., Sawamura, A., & Awata, N. (1992, Jan). “Usefulness of Taurine... and its Prospective Application.” Japanese Circulation Journal, 56(1), 95-9.
    2. Blazso, G and Gabor, M. (1980). “Odema-inhibiting Effect of Procyanidin.” Acta Physiologica Academiae ScientiarumHungaricae, 56(2), 235-240.
    3. Brattstrom, E. L, Hultberg, L. B., & Hardebo, E. J. (1985, Nov.). “Folic Acid Responsive Postmenopausal Homocysteinemia.” Metabolism, (34)11, 1073-1077.
    4. Colette, C., et al., (1988). “Platelet Function in Type I Diabetes: Effects of Supplementation with Large Doses of Vitamin E.” American Journal of Clinical Nutrition, 47, 256-61.
    5. England, M. R., et al. (1992, Nov. 4). “Magnesium Administration and Dysrhythmias...A Placebo-controlled, Double-blind, Randomized Trial.” Journal of the American Medical Association, 268(17), 2395-402.
    6. Felton, G. E. (1980, Nov.). “Fibrinolytic and Antithrombotic Action of Bromelain...” Medical Hypotheses (11)6, 1123-33.
    7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
    8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
    9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
    10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
    11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
    12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
    13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
    14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
    15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
    16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
    17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
    18. Mortensen, S.A.et al. (1985). “Long-term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure.” Drugs Exp. Clin. Res., 11(8), 581-93.
    19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
    20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
    21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
    22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
    23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
    24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
    25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
    26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
    27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
    28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
    29. Tsuyusaki, T. et al. “Mechanocardiography of ischemic or hypertensive heart failure,” in Yamaura Y et al., Biomed. & Clin. Aspects of Coenzyme Q.2 Amsterdam, Elsevier/North Holland Biomedical Press, 1980, 273-88.
    30. Verlangieri, A. J., & Stevens, J. W. (1979). “L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan S Incorporation...” Blood Vessels, 16(4), 177-185.
    31. Werbach, M. R. (1987). Nutritional Influences on Illness: A Sourcebook of Clinical Research. New Canaan: Keats Publishing, Inc.
    32. White, R.R., et al. (1988, Jul-Aug.). “Bioavailability of 125I Bromelain after Oral Administration to Rats.” Biopharmaceutics and Drug Disposition, 9(4), 397-403.
    33. Whitney, E. N., Hamilton, Nunnelly, E. M. (1984). Understanding Nutrition, (3rd ed.). St. Paul: West Publishing Company.
    34. Willard, Terry, Ph.D. (1992). Textbook of Advanced Herbology. Calgary, Alberta, Canada: Wild Rose College of Natural Healing.
    35. Xiang, H., Heyliger, et al. (1988, Nov.). “Effect of Myo-inositol and T3 on Myocardial Lipids and Cardiac Function in Streptozocin-induced Diabetic Rats.” Diabetes, 37(11), 1542-8.



    --
    VitaNet ®
    VitaNet ® Staff

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    Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...
    TopPreviousNext

    Date: May 24, 2005 09:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...

    Cognitive Improvement in Mild to Moderate Alzheimer's Dementia After Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Maria De Jesus Moreno Moreno, MD Instituto Nacional de la Senectud, Mexico City, Mexico


    This study assessed the efficacy and tolerability of the cholinergic precursor choline alfoscerate (CA) in the treatment of cognitive impairment due to mild to moderate AD (Alzheimer's disease).

    in both men and woman they consistently improved after 90 and 180 days versus baseline with adiministration of GPC three times a day, whereas in the placebo group they remained unchanged or worsened. Statistically significant differences were observed between treatments after 90 and 180 days.

    Keypoints:

  • improved cognition and global function
  • showed a statistically significant improvement after 90 and 180 days of treatment
  • Increased neurotransmission
  • With out treatment men and woman declined consistantly
  • references:

    Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction, Science. 1982;217:408-414. 2. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: Dementia and Alzheimer's disease. Annu Rev Public Health. 1992;13:431-449. 3. Hofman A, Rocca WA, Brayne C, et al, for the European Prevalence Research Group. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int d Epidemiol. 1991;20:736-748. 4. Blackwood W, Corsellis JAN, eds. Greenfield's Neuropathology. 3rd ed. London: Arnold; 1976. 5. Geldmacher DS. Cost-effective recognition and diagnosis of dementia. 5emin Neurol. 2002;22:63-70. 6. Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 1978;2:1457-1459. 7. Perry EK. The cholinergic hypothesis--ten years on. Br Med Bull. 1986;42:63-69. 8. Giacobini E. From molecular structure to Alzheimer therapy. Jpn d Pharmacol. 1997;74:225-241. 9. Giacobini E. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications. Neurochem Int. 1998;32:413-419. 10. Brinkman SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's disease. J Gerontol. 1982;37:4-9. 11. Davis E, Emmerling MR, Jaen JC, et al. Therapeutic intervention in dementia. Crit Rev Neurobiol. 1993;7:41-83. 12. Amenta E Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropiate approaches? Mech Ageing Dev. 2001;122:2025-2040. 13. Sigala S, Imperato A, Rizzonelli P, et al. k-Alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eurd Pharmacol. 1992;211:351-358. 14. Govoni S, Battaini E Lucchi L, et al. Effects of alpha-glycerylphosphorylcholine in counteracting drug-induced amnesia: Through cholinergic and non-cholinergic mechanisms [in Italian]. Basi Raz Ter. 1991;21:75-78. 15. Canonico PL, Nicoletti F, Scapagnini U. Neurochemical and behavioral effects of alpha-glycerylphosphorylcholine [in Italian]. Basi Raz Te~ 1990;20: 53-54. 191 CLINICAL THERAPEUTICS ® 16. Parnetti L, Amenta E Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: An analysis of published clinical data. Mech Ageing Dev. 2001;122:2041-2055. 17. Venn RD. The Sandoz Clinical Assessment-Geriatric (SCAG) scale. A general-purpose psychogeriatric rating scale. Gerontology. 1983;29:185-198. 18. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991;19:330-341. 19. Frattola L, Piolti R, Bassi S, et al. Multicenter clinical comparison of the effects of choline alphoscerate and cytidine diphosphocholine in the treatment of multi-infarct dementia. Curt Ther Res Clin Exp. 1991;49:683-693. 20. Muratorio A, Bonuccelli U, Nuti A, et al. A neurotropic approach to the treatment of multi-infarct dementia using L-c~-glycerylphosphorylcholine. Curt Ther Res Clin Exp. 1992;52:741-75l. 21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: APA; 1994. 22. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944. 23. Folstein ME Folstein SE. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198. 24. Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke. 1983;14:399-401. 25. Hamilton M. A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960;23:56-62. 26. Hamilton M. Development of a rating scale for primary depressive illness. BrJ Soc Clin Psych& 1967;6:278-296. 27. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. AmJ Psychiatry. 1984;141:1356-1364. 28. Reisberg B, Ferris SH, De Leon MJ, et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136-1139. 29. National Institute of Mental Health. Clinical global impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Revised edition. Rockville, Md: National Institute of Mental Health; 1976:217-222. 30. Burns A, Russell E, Page S. New drugs for Alzheimer's disease. Br J Psychiatry. 1999;174:476-479. 31. Kumar V, Anand R, Messina J, et al. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159-169. 32. Knapp MJ, Knopman DS, Solomon PR, et al, for the Tacrine Study Group. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 1994;271:985-991. 192 M. Moreno 33. Lindstrom MJ, Bates DM. Newton-Rapshon algorithms for linear-mixed effects models for repeated measure data. J Am Stat Assoc. 1998;83:1014-1022. 34. Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-711. 35. Rogers SL, Friedhoff LT, for the Donepezil Study Group. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia. 1996;7:293-303. 36. Rogers SL, Doody RS, Mohs RC, Friedhoff LT, for the Donepezil Study Group. Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Arch Intern Med. 1998; 158:1021-1031. 37. Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group. A randomized trial evaluating the efficacy and the safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1998;1:55-65. 38. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial. BMJ. 1999;318: 633-638. 39. Amenta E Bronzetti E, Del Valle M, Vega JA. Effects of alpha-glycerylphosphorylcholine in neuroanatomy of aging brain in experimental animals [in Italian]. Basi Raz Te~: 1990;20:31-38. Address correspondence to: Scientific Department, Italfarmaco SpA, via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy.

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    KudZu, Treatment of alcohol dependence or alcohol abuse
    TopPreviousNext

    Date: May 19, 2005 09:29 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: KudZu, Treatment of alcohol dependence or alcohol abuse

    For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.

    Alcohol abuse

    Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.

    While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.

    Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:

    CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH

    In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:

    CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH

    Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).

    Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.

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    Androgens and 4-Diol and 4-Dione conversion to Testosterone...
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    Date: May 17, 2005 04:47 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Androgens and 4-Diol and 4-Dione conversion to Testosterone...

    The androgens 4-androstenediol and 4-androstenedione are natural testosterone precursors. The biosynthesis of testosterone takes place within the testicular Leydig cells in two metabolic pathways. During the progesterone-pathway (.delta.-4 pathway), pregnenolone is metabolized to progesterone by the 3-.beta.-hydroxy-steroid deydrogenase and an isomerase. Progesterone is then changed to 17-.alpha.-hydroxyprogesterone by the 17-.alpha.-hydroxylase and C.sub.17C.sub.21-lyase to androstenedione, then to testosterone by reduction of the 17-keto-group by 17-.beta.-hydroxy-steroid dehydrogenase. The DHEA-pathway (.delta.-5 pathway) leads from pregenolone to 17-.alpha.-hydroxypregnenolone to dehyroepiandrosterone (C.sub.17C.sub.21-lyase), to 5-.delta.-androstenediol. See FIG. 4; Wichmann et al., 83(3) EXP. CLIN. ENDOCRINOL. 283-290 (1984).

    As a testosterone pro-hormone and metabolite, 4-androstenedione may be used by athletes and bodybuilders to improve muscle mass. Levels of .delta. 4-androstenedione increase significantly with moderate exercise in healthy men. Velardo et al., 97(1) EXP. & CLIN. ENDOCRINOL. 99-101 (1991). Additionally, supplementation with 4-androstenedione has been known to produced elevations in serum testosterone. Mahesh et al., 41(3-8) J. STEROID BIOCHEM. MOL. BIOL. 495-513 (1992).

    4-androstenediol is also metabolized into testosterone and is produced by conversion of dehyroepiandrosterone. Inaba et al., 13(2) ENDOCRINOLOGIA JAPONICA 160-72 (1966). It was first shown to produce elevations in human serum testosterone levels in 1965, and this was also demonstrated in in vitro studies in animals (Kundu, 6(5) STEROIDS 543-51 (1965) and human fibroblast cultures. Faredin et al. 32(2) ACTA MEDICA ACADEMIAE SCIENTIARUM HUNGARICAE 139-52 (1975). Supplementation with 4-androstenedione, 4-androstenediol, and 19-nor-4-androstenedione has been studied to determine whether a rise in testosterone is produced. Uralets et al., 23 ANAL. TOXICOL. 357-366 (1999). Testosterone is excreted in the urine unchanged and is metablized through 5.alpha.- and .beta.-DHT as 5.alpha.- and .beta.-androstanediol, while androstenedione is similarly excreted as androsterone and etiocholanolone. Both the final excreted steroid and the intermediaries stanediones and DHT intraconvert so that androsterone, 5.alpha.- and .beta.-androstanediol and etiocholanolone are seen in urine. Supplementation with 4-androstenediol produced a 10-fold greater urine testosterone concentration than 4androstenedione. (Uralets, 1999)



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    Important Information for Allergy Sufferers
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    Date: May 13, 2005 09:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Important Information for Allergy Sufferers

    Important Information for Allergy Sufferers

    Richard Conant, L.Ac. C.N.

    Imagine you are one among millions who greet each spring with worry about the flood of pollen that fills the air this time of year. When the pollen season arrives, as it inevitably does, you find yourself with two choices. You can either take over-the-counter antihistamines and put up with unpleasant side-effects, or endure the sneezing, runny nose, itchy, watery eyes and other discomforts of hay fever.

    If there was a natural ingredient, a nutritional substance found throughout nature in many foods and plants, that could offer an alternative, would you not be interested?

    Quercetin, one among hundreds of flavonoids found throughout the plant kingdom, is this ingredient. Quercetin has been researched in numerous pharmacological studies. The results of this work strongly suggest that quercetin helps to stabilize the fundamental process in the body which causes an allergic reaction. Quercetin, as shown in test-tube ("in vitro") studies, prevents the release of histamine from "mast cells," immune cells that stand guard in the tissues which meet the outside environment—the nasal passages, the lungs, the digestive tract and skin. While this has yet to be confirmed by human clinical trials, in the picture that emerges from the research so far, quercetin looks like a rescue nutrient for allergy sufferers.

    Reports from Quercetin Users

    I have seen numerous reports from individuals who have indeed achieved significant reductions in allergic sensitivity by using quercetin. And this includes food allergies as well as environmental allergies. Anecdotal stories like these carry little weight among scientists, because they do not provide evidence that the observed result will be repeated in other cases. Only placebo-controlled, double-blind studies can produce this kind of scientific proof. Yet, when anectodal evidence (this includes physician "case reports") correlates with the results of pharmacological research such as we have on quercetin, I believe it should be taken seriously. And quercetin is a nutrient that works effectively when taken as a dietary supplement.

    For example, one gentleman writes that his wife, who is allergic to pollen and dust, is now "sneeze-free" after using quercetin for three years. A Pennsylvania woman writes that her husband, also a long time allergy sufferer, "seems to be nearly allergy free" after one month of use. Another man says that "quercetin has literally changed my life." These are not isolated cases; a respected nutritionist who specializes in allergies and environmental problems has seen many similar outcomes with a quercetin. Clearly something significant is going on with respect to quercetin as a nutritional approach for overcoming allergies.

    Bear in mind, though, that quercetin does not function like an antihistamine medication; it is not a quick fix. As a nutrient that helps to normalize body functions naturally, quercetin needs time to work, and should be taken for at least two or three weeks to achieve these results.

    Quercetin Quiets the Allergic Response

    Exerting a broad range of biological effects, quercetin is perhaps the most active and versatile flavonoid. In test-tube studies, quercetin acts directly on the mast cell in a way that quiets the allergic response.

    An allergic reaction occurs when IgE antibodies, positioned on the mast cell surface, come in contact with a potential allergy-causing substance like pollen. The mast cell is then signaled to release histamine from storage granules located inside the cell, through a process called "degranulation." The histamine circulates throughout the body, causing the runny nose, itching and other discomforts associated with allergies.

    Quercetin stabilizes mast cell membranes, in effect turning down the allergic response signal. Quercetin also slows other mechanisms which are involved with inflammation, such as the production of inflammatory prostaglandins and leukotrienes. This adds to its membrane-stabilizing effect, and its value in allergy control.

    Quercetin appears to substantially raise the threshold for initiation of an allergic reaction. In allergy sufferers this threshold is low, for reasons which are not well understood. They may have more IgE antibodies than normal, making the mast cells overly "trigger happy." Histamine has its proper place in the immune response that defends us against truly harmful foreign substances in the body. But like many chemicals produced by the body, histamine is a two-edged sword. In allergy-prone individuals, the mast cells have become overreactive, releasing too much histamine, unnecessarily. With quercetin in the bloodstream, histamine release from mast cells is kept under control. Quercetin's ability to down-regulate both the inflammatory and allergic responses makes it, I believe, a highly important nutrient for humans to consume on a regular basis.

    Quercetin-the Scientific Evidence

    Several studies, published in respected journals such as the Journal of Allergy and Clinical Immunology and others, have demonstrated quercetin's ability to control the release of histamine from mast cells. (Quercetin has the same effect on basophils, a type of white blood cell that also contains histamine.) In these experiments, mast cells taken from both animals and humans are exposed in the test tube to various substances—called "antigens"— that stimulate histamine release. The researchers then add an inhibiting agent such as quercetin to the mixture and measure the differences in histamine output. Quercetin has shown itself to be one of the more powerful histamine inhibitors, more powerful, in fact, than disodium cromoglycate, an anti-asthma drug.

    Quercetin has other beneficial properties. A strong antioxidant, Quercetin has a higher level of antioxidant activity than both vitamin C and vitamin E. (Quercetin enhances the antioxidant activity of vitamin C; quercetin and vitamin C are true synergists.) Quercetin has been shown to block the oxidation of LDL cholesterol by free radicals. Quercetin also protects cell membranes from being injured by oxidized LDL. The damage that oxidized LDL causes to the delicate membranes of blood vessel linings allows plaque deposits to form, setting the stage for atheroslcerosis. These observations point to quercetin as a key nutrient for maintaining cardiovascular health.

    Like all flavonoids, quercetin is not classified as an essential nutrient, although flavonoids were once called "Vitamin P." In view of its many beneficial actions, quercetin is a nutrient that clearly has important roles to play in human nutrition, for allergy sufferers, and for everyone.

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