Search Term: " experimens "
Researchers reveal how the common curry spice turmeric kills coloncancer cells
April 19, 2019 02:20 PM
Studies are now showing that turmeric, which is a common spice found in curry, can actually help kill off colon cancer cells to help the disease from progressing. They believe that these healing properties are due to the curcumin content that is found within the spice itself. If you're searching for ways to take in adequate amounts of turmeric, try consuming turmeric tea. For a more savory option, turmeric tastes fantastic when sprinkled on roasted produce.
"In this study, published in the journal Nutrition Research, the researchers hypothesized that curcumin-induced ROS works against colon cancer by promoting apoptosis and inhibiting the cell cycle. They tested this through in vitro experiments involving Smd4 and p53 mutated HT-29 colon adenocarcinoma cells."
Read more: https://www.naturalnews.com/2019-02-27-common-curry-spice-turmeric-kills-colon-cancer-cells.html
Sea buckthorn oil can promote liver health and decrease the storageof body fat
September 06, 2018 09:52 AM
More study is now being done regarding lesser known fruits and vegetables, not only for the betterment of human understanding, but also to potentially augment the list of natural alternatives to pharmaceuticals for the improvement of human health.
Healthy lipids and fatty acids have been on the nutrition radar for a while now, as these items are known for having useful bioactive ingredients, including high vitamin content, making them useful for human consumption. Sea buckthorn oil is a new face on the lipid list, but offering some impressive credentials. For example, the plant shows high levels of vitamin A and E, phytosterols and unsaturated fatty acids. One study suggests that the type of oil used by humans effects how much vitamin A the liver stores. The ware-housing effect was considerably upped when rats were given sea buckthorn oil as opposed to soybean oil. Sea buckthorn oil has other pluses too. It can reverse GERD and possibly ulcers, also lower cholesterol and promote heart health. It also reduces inflammation, making it useful for sore inflamed, reddened skin.
"Lesser known fruits and plants have been gradually taking the spotlight in alternative medicine as natural remedies to various health conditions and improving overall nutrition."
Read more: https://www.naturalnews.com/2018-09-01-sea-buckthorn-oil-can-promote-liver-health.html
3 Science-backed nutritional benefits of echinacea
May 10, 2018 09:16 AM
The echinacea is a coneflower that is not only wonderful to look at in it's pink aura, but it is also a species that provides our bodies with substantial health benefits. The plant is known to help boost our immune systems, especially when it comes to ailments or symptoms that involve our respiratory systems. Experiments on lab rats have also shown that regularly taking in echinacea can help decrease anxiety levels quite a bit as well.
"The deliciously pink coneflower, otherwise known as echinacea, is one of nature’s power plants (pun intended). Healers from all disciplines recognize the healing potential of echinacea and often prescribe it as an alternative treatment for various conditions."
Read more: https://www.naturalnews.com/2018-05-08-3-science-backed-nutritional-benefits-of-echinacea.html
Can turmeric really shrink tumours, reduce pain and kill bacteria?
May 09, 2017 08:44 AM
According to Gunveen Kaur, the food turmeric is a miracle substance. This yellow-colored spice, widely used in India and South East Asia, supposedly contains anti-inflammatory, anti-bacterial, and anti-cancer properties. Additionally, this substance encourages the death of cells that are dangerous or no longer needed in the human body. According to Kaur, systemized studies have supported these assertions to certain extents. While these findings are quite promising, more work needs to be done to validate and study how much of an impact this miracle food has on the health of others.
"Although curcumin is showing some encouraging effects in reducing markers of inflammation in humans, the majority of the pharmacological effects of curcumin are in lab studies or animal experiments."
Read more: https://medicalxpress.com/news/2017-04-turmeric-tumours-pain-bacteria.html
Shocking experiments show how much damage energy drinks do to your teeth
March 14, 2017 08:59 AM
Energy drinks are used and enjoyed by many people, but it seems the dangers of doing this keep getting worse. New evidence suggests that energy drinks rot your teeth and the results of a recent study show what happens when the drinks are consumed on a regular basis. Are you interested to know what energy drinks can do to your teeth? Should you discontinue use of these drinks now that this evidence is out and about?
"The tooth that had been placed in the energy drink showed that the enamel, which is the hard coating that protects the dentine underneath, had begun to crumble away."
Read more: http://www.naturalnews.com/2017-03-09-shocking-experiments-show-how-much-damage-energy-drinks-do-to-your-teeth.html
How rare sugars might help control blood glucose
March 13, 2017 06:59 AM
Someone's glucose levels being too high can be a major problem. This can cause many health issues. It can even lead to diabetes. This talks about how rare sugars can actually help lower levels. It's funny to think of sugars being good for you but this explains it in a more understandable way.
"In an era when the label “natural” hits a sweet spot with consumers, some uncommon sugars emerging on the market could live up to the connotation."
Resveratrol Is Good For Diabetic People
March 11, 2017 02:59 PM
Resveratrol is really good for diabetic people. It can be a part of treating diabetes. In one study, it was found that resveratrol helps with controlling blood sugar levels. There were other experiments done as well to see what the effects were. It was found in the end that the drugs used to treat diabetes can now be used to treat Alzheimer's disease.
"The medications or drugs that are used to control levels of glucose and regulate diabetes can be used to halt the onset of dementia as the two diseases are very much alike."
Is CBD Crystalline the Most Effective Cannabis Medicine?
January 03, 2017 02:59 PM
Information regarding the use of medicinal marijuana has been in high demand over the past few years. This article discusses the positive impacts and benefits of CBD. There are several conditions that cannabinoids have been shown to benefit. Check out the article for those conditions and the progress researchers have been making
"CBD provides no psychoactive effects when ingested, but being that it is derived from cannabis, the potential life-saving compound is still considered a Schedule 1 substance with “no medicinal value.” This obstacle blocks many professional research facilities from conducting experiments with CBD to truly put its healing abilities to the test, at least in the United States."
New antibiotics discovered by sifting through the human microbiome
December 01, 2016 08:59 AM
For Computer software to help discover new antibiotics is incredible. It's fascinating how far we have come with technology. Synthesizing is such an interesting concept. The experiments that suggested that the humimycins worked by inhibiting an enzyme that bacteria use to build their cell walls - and once that cell-wall building pathway is interrupted, the bacteria died. Wow, such a wonderful discovery.
"The software initially identified 57 potentially useful gene clusters, which the researchers winnowed down to 30."
Why wounds heal more slowly with age
December 01, 2016 06:59 AM
Our bodies undergo many changes when we age. Once potentially problematic change is that our bodies take longer to heal when we are older. This phenomenon has been observed since WWI. Recent studies at Rockefeller University have focused on observing young and elderly mice to determine why this happens. It has been discovered that our immune cells stop communicating effectively in old age, which leads to them not doing their jobs as quickly as when we are young.
"Recent experiments at The Rockefeller University explored this physiological puzzle by examining molecular changes in aging mouse skin."
Microbes in your gut influence age-related macular degeneration
November 29, 2016 02:59 PM
Age-related macular degeneration affects over 10 million people in North America. A study performed in Montreal has recently discovered that bacteria in our guts may be the culprit behind a specific form of the disease called blinding wet age-related macular degeneration. The bacteria cause inflammation that leads to deposits of fat debris in the back of the eyes and destruction of nerve cells. It is suggested that diets with high fat intake alter the stomach bacteria and make it possible for this scenario to occur.
"Among the series of experiments conducted as part of this study, the group performed fecal transfers from mice receiving regular fat diets, compared to those receiving a high fat diet, and found a significant amelioration of wet AMD"
Kava Roots Helps Those Suffering From Anxiety
September 21, 2016 05:25 PM
Anxiety is a common mental disorder. Many treatment and preventive tips are available for these illnesses. For those who want to avoid prescription drugs, consider trying kava root as an alternative.
Kava Root has been used for:
Another common uses of kava root is for the improvement of sleep quality and pattern, and the relief of general body malaise, asthma attacks, insomnia and menopausal symptoms.
Does Beta Sitosterol Help Reduce Cholesterol?
November 14, 2013 09:47 PM
About Beta Sitosterol
A high cholesterol level in the body is a cause to worry. Many people on learning that their cholesterol levels are way above the norm resort to healthier diets and regular exercises. While these mainstream methods of lowering cholesterol work, researchers have explored other different options that involve the use of cholesterol lowering supplements; Beta Sitosterol.
What is Beta Sitosterol
Beta Sitosterol is a plant sterol that is largely medicinal. Credible studies have shown that this compound is indeed capable of reducing cholesterol. It is able to do this by inhibiting the absorption/uptake of cholesterol from the gut. Researchers have had to perform extensive experiments to come up with these findings about the Beta Sitosterol. But how exactly does this compound achieve this?
Benefits of Beta Sitosterol
Beta Sitosterol’s chemical structure is quite similar to that of cholesterol. On ingestion and during absorption in the intestine, Beta Sitosterol will effectively compete and take the place of dietary cholesterol in the micelles thus inhibiting/lowering its absorption. Furthermore, upon absorption, Beta Sitosterol gets incorporated into the cell membrane further reducing uptake of cholesterol. This happens when Beta Sitosterol inhibits the transportation of cholesterol to the smooth endoplasmic reticulum from the outer cell membrane. This reduces Low Density Lipoproteins (LDL-bad cholesterol) and serum cholesterol levels.Beta Sitosterol is also said to increase the receptability of the liver cells to LDL. This means that the liver cells are able to effectively absorb LDL from the blood stream reducing the level of cholesterol in the blood. Dietary cholesterol on the other hand is excreted. the use of Beta Sitosterol as a cholesterol reducing supplement has made it possible to reduce cholesterol without dieting or engaging in rigorous exercises. Users of Beta Sitosterol are however warned about prolonged use of this sterol. High concentrations in the body may have dire consequences.
Can Glutathione Taken Orally Be Effective?
December 28, 2012 04:12 PM
One of the main antioxidant found in the human body is glutathione. The chemical nature of it is made up of three amino acids together bound with tripeptide bonds. The many functions of glutathione in human body include gene expressions, DNA synthesis, protein synthesis, etc. It has been noted that deficiency of this chemical in human body gives rise to diseases and problems like Parkinson's diseases, AIDS, epilepsy, sepsis, Alzheimer's disease, cardiovascular troubles, trauma, Schizophrenia and many others.
The amino acid that is extracted from the protein containing food consumed by an individual helps in the formation of glutathione in the body itself. Many medical personalities might suggest the consumption of oral glutathione pills by those who have glutathione deficiency. It must however be noted that the answer to the question can glutathione taken orally be effective is a widely debated topic. Most of the recent medical tests and experiments suggest that although no forms of side effects are caused by oral consumption of this chemical as pills, but effectiveness of the medicine is not 100%.
The chemicals and organic supplements present in glutathione are not 100% absorbed by the body when it is taken orally. Without intravenous administration, this chemical would never provide the required results in maintaining a healthy body. The glutathione, when taken down orally, is partly broken in the digestive canal, especially in the small intestines through the enzymes that are present. Hence most of the benefits of this chemical would be lost adding to the cellular toxicity of the body if consumed orally. Most doctors and medical professionals suggest that instead of taking glutathione orally as pills, one should have food that is protein rich.
Consumption of protein rich food, especially protein shakes, in turn, adds to the intravenous glutathione production which is best suited for the body. Consuming NAC can help boost glutathione levels as well.
Bitter Orange Extract
November 22, 2012 10:46 AM
Indigenous to the Meditteranean region today, but brought to their shores by Arab tradesmen in 1200 , bitter orange or citrus aurantium was highly popular among herbalists all over the southern parts of Europe is mainly France, Greece, Spain and Italy. A botanical species commonly termed as seville orange and bigarade orange, this bitter citrus fruit is known for its oil extract, flavoring and use in the perfume industry.
However , the ancient Chinese used it for treating dyspepsia , abdominal distention and diarrhea. These uses also drew from its roots in ancient Greek experiments in aromatherapy, phyto-therapy and cosmetology. Its arrival in America can be credited to the Spaniards and the Portuguese who for very long had been using the fruit for its medical component. Bitter orange trees grew in abundance in the states of Florida, Louisiana and California way back in the middle of the nineteenth century.There have been numerous pharmacological indicators in the study of C aurantium actions and it has been termed as an anti spasmodic, anti fungal , anti bacterial, anti-inflammatory, sedative, tranquilizer and also a vascular stimulant.
Recent studies about its effect on cancer cells is underway. A Closer Look At Its Health Benefits Bitter orange peel, flower and seed are known to have varying effects on the human body and its studies date back centuries. Quite simply it has the ability to squeeze blood vessels, affect the heart rate and also change the level of metabolism. A closer look at its components would help focus on their particular impact on health.
It results in faster metabolism, increase in heart rate by affecting the adrenaline system, and in turn aid in weight loss. What needs to be seen is whether this metabolism booster is in any way a retardant with any other medication that you may be taking.
Many have reverted to bitter orange extracts to tackle their weight problem after the ban on ephedra by the US drug administration . what is needed is prudence as most consider bitter orange as a health supplement forgetting its rather potent effect on the body .
Benefits of magnesium chelate
June 23, 2012 02:31 PM
According to various authority websites on the internet magnesium chelate usage can result in positive effects for the human body. The fact is that people will need to balance its use and not take too much, because otherwise, like with any overdose, they will be in for some side effects.
The way it works
There are basically two types of magnesium out there and they number the insoluble and the soluble version. The latter gets absorbed by the human body very well, but when it comes to the former, it will take some time until the body manages to dissolve and absorb it. One of the benefits of using the soluble version is that the body can absorb it very easily and after that supplement the entire system, maintain a healthy level of magnesium and improve the immune system. For adults it's recommended they would take four hundred milligrams of magnesium on a daily basis, depending on their size and gender.
The truth is that magnesium chelate is an amino acid that occurs naturally in the human body. Some of its positive side effects number improving the normal functioning of the heart, of the muscles, of the bones and also an improvement in the bloodstream of magnesium deficient individuals. There are also many people who choose to take magnesium in order to improve the quality of their sleep by calming down their entire nervous system.
On top of that, magnesium also showed positive effects in helping the body absorb potassium, calcium, decrease the risk of heart attacks, maintaining a low blood pressure and reducing high blood pressure.
Diabetes is a lifelong disease, but studies and experiments have shown that taking magnesium people will be able to defer it. Those who have a deficiency in this element will oftentimes feel weak, deal with nauseas and experience fatigue. In some cases it can lead to an impaired cardiovascular function and even seizures.
For a healthy cardiovascular function and strong bones, calcium is a must for everyone. More to that, if an individual has a low magnesium level this can be mainly because of a low blood calcium.
Guidelines for taking magnesium chelate
Many health institutes recommend that adults (women) who are between nineteen to thirty years old will take three hundred and ten milligrams of magnesium on a daily basis. After the age of 30, they should take three hundred and twenty mg per day. In regards to men between 19 and 30 years old and even beyond that, they should take four hundred mg per day and four hundred and twenty mg respectively. In case of an overdose (even though it's very rare) people will experience gastrointestinal distress and to avoid it, they should strictly follow the recommended dosage.
As people can see, taking magnesium can be quite beneficial for the overall healthy functioning of their body, yet as with any type of drug out there, taking too much of it can have a few undesired side effects.
Bioperine Promotes Maximum Absorption
February 06, 2012 06:19 PM
Bioperine is an extract from black pepper that contains about 95 percent piperine. Piperine is an alkaloid, the active substance that contributes to nutrients bioavailability and absorption. Bioperine can be combined with other specific nutrients to form different nutritional supplements that can be used for both animal and human consumption. Black pepper is mostly harvested before ripening, dried in the sun and then the extraction process begins.
How and why use of Bioperine promotes maximum vitamin absorption
Recent research has shown that the use of Bioperine, whose main constituent is piperine, increases thermogenic activity in the body. Thermogenesis is an accelerated metabolic process that takes place in the body cells in which conversion of glucose into energy takes place. An increase in absorption of discount minerals such as selenium and vitamins such as vitamin A has been witnessed to be triggered by the use of Bioperine. Piperine works through initiating the release of catecholamines hormones that stimulate thermogenesis. However, the nutrients should presently available during this time since; the process takes place for a short duration.
Piperine improves the necessary conditions of the intestines thus enhancing vitamins absorption. It alters the intestinal epithelial cell wall making it more permeable to vitamins and minerals. In addition, absorption of protein supplements such as those used by people who are on a dietary weight loss program is also increased. Several researchers have also shown that Bioperine has other benefits in the body, these includes the antibacterial properties and anti allergy properties.
Experiments prove that use of Bioperine increases vitamin and mineral absorption
Several studies on how much piperine promotes nutrients absorption have been carried out hitherto. For instance, an experiment was carried out on the effect of absorption of beta-carotene, vitamin B-6 and selenium which are fat soluble vitamin, water soluble vitamin and mineral in the form of selenomethionine respectively in the presence and absence of piperine. The experiment showed that absorption of these vitamins and mineral selenium increased appreciably when taken with Bioperine. There was 60 percent increase in absorption of beta-carotene and vitamin B-6 while 30 percent absorption was noticed for selenium. The experiment was carried out using 5 milligrams of Bioperine. Another experiment also showed a 30 to 200 percent increase in the absorption of Coenzyme Q-10.
Bioperine is the only piperine product to undergo comprehensive health tests and to be patented for the effect of increasing nutrients absorption, more so vitamins and minerals. By creating metabolic changes that require vitamins and minerals, Bioperine creates a nutritional need and then follows by increasing the nutrients bioavailability to meet the need. However, the process takes place in a short period. It is therefore advisable to co-administer minerals and vitamins with Bioperine so that they will be available during the right time for absorption. Unfortunately, research has shown that taking black pepper in its natural form does not yield the same results as those of taking Bioperine. This is mainly because the bioavailability of piperine is not that high in the natural form. Finally, antibacterial and anti allergy properties of Bioperine diversifies its application in medication.
Can tea Tree Oil Kill Bugs?
September 26, 2011 11:26 AM
Tea tree oil is known as an essential oil which is light yellow in color with a camphoraceous scent. It is extracted from the leaves of Melaleuca alternifolia which originates from the northeast coast of Australia. The other name of tea tree oil is melaleuca oil.
Tea tree oil has been studied on its medicinal benefits. Such studies revealed that tea tree oil has a potent anti-viral, anti-bacterial, and anti-fungal properties. In fact, since the olden times, tea tree oil can administered topically as an antiseptic agent. In addition, tea tree oil is also popularly used as one of the ingredients among many cosmetic products. Industrially, tea tree oil has been controversial whether it can be used to kill bugs or not.
Experiments on "concentrated" tea tree oil and bed bugs have shown that it can effectively kill bugs and other insects. However, it cannot be used at home because concentrated forms of tea tree oil have been found to be toxic to the human body. The commercial preparation of tea tree oil is diluted so that it cannot cause harmful effects to the body. Diluted tea tree oil, on the other hand, cannot kill bugs and insects. Health experts also further stipulated that it is significantly dangerous to use “concentrated” tea tree oil at home specifically at your bedroom. If tea tree oil in undiluted form is introduced inside the body either by ingestion or inhalation, it can have a negative effect on the liver so it is wise to always dilute this oil before ingesting.
If the room is exposed to “concentrated” tea tree oil, make sure to open the windows and provide adequate ventilation. Avoid entering the room for a short span of time because it the air is toxic. Eventually, if “concentrated” tea tree oil is smeared on the skin, it may cause inflammation as manifested by swelling and redness, blistering and itching. If swallowed, concentrated tea tree oil can cause significant diarrhea.
If diluted tea tree oil is employed for bed bugs, it can only make the bugs weak, not killed. The diluted form of tea tree oil is non – toxic to humans and is considered to be a cheaper remedy for the control of bed bug bites. Therefore, it can kill bugs but in concentrated form. However, concentrated tea tree oil must not be used as a household insect killer because of its toxicity. On the other hand, diluted form of tea tree oil is non – toxic but in cannot kill bugs and insects.
As mentioned earlier, tea tree oil is used as an ingredient of many cosmetic products such as facial creams, ointments, lotions, soaps, shampoos and even acne removing agents. Allergic reaction to tea tree oil is rare. However, if hypersensitivity occurs, manifestations include mild dermatitis, blister formation and rashes. It is important to remember that tea tree oil is for external use only. It must not be introduced inside the body even in very small amount because it can cause mild to severe adverse reactions. If untoward effects occur after use, consult your doctor.
How Does Malic Acid Help With Fibromyalgia?
August 22, 2011 12:37 PM
Fibromyalgia(FM) is a condition affecting primarily middle-aged women and is often misdiagnosed and misunderstood as an ailment which has a diverse set of symptoms, in which none are pleasant. It basically is a medical disorder defined by chronic and widespread pain, a heightened response to pressure and often time painful as well. No one really knows what the exact causes are. There are a number of studies taking place and done by reputable medical organisations (such as the Nation Institute of Arthritis and Musculoskeletal and Skin Diseases - NIAMS) which are geared towards the establishment, once and for all, of the route cause of Fibromyalgia. A part of the current scientific theories is the inherent genetic factor, but even in this it seems that geneticists are not clear as to which genes exactly may be the culprit. What has been concretely established and clarified though is that not just because your mom or dad has it you’ll have it. Stress in some studies has also been found as a contributor but may not be the main cause though.
Malic acid is an organic compound and also a carboxylic diacid and is an active ingredient in many sour or tart foods. It is mostly in unripe fruits and it has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of this diacid are called malates. The malate anion is an intermediate in the citric acid cycle. However it was not until 1785 that Carl Wilhelm Scheele first isolated it from apple juice. It is formed in metabolic cycles within the cells of plants animals and humans. A somewhat large amount of Malic Acid is produced and broken down in the body each day. Malic acid also provides stamina and endurance within the muscle cells. It is particularly useful in the blocking of aluminum toxics, which has been found to possibly be one contributing factors to fibromyalgia.
Compelling evidence has surfaced that malic acid may plays a central role in energy production, especially during hypoxic conditions. In some experiments that have been done, the improvement that came about when malic acid was administered to the subject was gone after discontinuing for 48 hours. The theory behind this is in the relative association of hypoxia to FM, if it will improve hypoxic conditions then it will be beneficial for FM sufferers as well just as Chronic Fatigue Syndrome has also been associated with FM. Additionally, many hypoxia related conditions, like respiratory and circulatory insufficiency, are related to deficiency in energy production as well. Therefore, malic acid may be of benefit in these conditions.
The mitochondria are the energy furnaces in cells which metabolize food for energy. Some findings suggest that this structure does not operate efficiently in those with FM. So, for the mitochondria to produce ample amounts of ATP, several nutrients are essential and Malic Acid is one of them. Imbalances in the mitochondria’s process can cause the body to switch from oxygen-based metabolism to the less efficient anaerobic metabolism and this would contribute to an abnormal buildup of lactic acid following even light exertion. This lactic acid buildup results in fatigue, weakness, pain and muscle spasms.
How Does Lithium Help with Memory and Mental Disorders?
July 04, 2011 08:42 AM
Lithium And The Brain
Lithium is a chemical element whose ions have been observed to display pharmacological effects. It is best known as a treatment for mania and remains to this day an approved drug for mood disorders in several countries, including the US. It has been associated with countless scientific studies since the latter half of the 19th century. It is one of the most extensively studied of all drugs that alter mood.
Depression is an ancient disease of the mind that was referred to as melancholia in the ancient world. It has been noted in religious writings over the centuries. High energy levels and mental hyperactivity characteristic of bipolar disorder were once associated with supernatural causes. Religious beliefs have historically considered mental disorders as the work of the devil, and melancholia is not an exception.
Melancholia and mania were two separate mental conditions. The former was always tied to evil forces whereas the latter were thought to be triggered by other supernatural causes. Early Greek and Roman physicians noted that active behavior deemed to be pathological could be cured by drinking spring waters. Research have studied and reported that these spring waters actually contained lithium salts.
Manic depression was first posited in the 1950s to be a mental illness distinct from both melancholia and mania. It was in France when two psychiatrists independently observed the type of insanity that oscillates from between bouts of depression and mania. It was later categorized as a specific type of psychosis in that the condition was acute, and thus the patient functions normally after recovery.
Lithium was introduced as a treatment for manic depressive disorder in the form of lithium carbonate in the first half of the 20th century. Its use was discovered when lithium urate produced tranquilizing effects on animal subjects. Lithium salts were used as tranquilizers shortly after. Human experiments have proven to be effective in controlling patients chronically suffering from bouts of manic disorders.
Bipolar disorder is now the widely used term in psychiatry, though manic depression is still preferred by many medical professionals. It was first used in the 1950s to describe oscillations between two polar behaviors: mania and depression. It is a subtype of depression, the other one being major depression or unipolar depression. Lithium remains a drug for mania amid its changing descriptions.
Medicinal concentrations of lithium are generally considered safe in that they produce no apparent psychoactive effects. Instead, they work as a therapeutic treatment. It has been widely established that lithium possesses properties that stabilize mood, though its mechanism of action is still a matter of controversy. It is believed that lithium rebalances brain chemicals and alters gene expression.
Lithium appears to have an impact on several neurotransmitters present in the central nervous system, such as glutamate and serotonin Inasmuch as these neurotransmitters are noted for their role in mood and memory, some sources have ascribed nootropic effects to regular intake of lithium supplements.
Lithium is a wonderful supplement available over the counter. Try some Lithium today and feel the difference!
Turmeric, Curcumin, And Good Health
November 11, 2010 03:48 PM
Turmeric and its historyTurmeric is not just an ancient Asian spice but also an effective traditional alternative medicine used worldwide. Turmeric is a spice that originates in India and has been long used in both Ayurvedic and Chinese traditional medicine. This spice comes from the herb Curcuma longa L. which is a member of the Curcuma botanical group, a part of the ginger family of herbs called Zingiberaceae. The root and rhizome (underground stem) of this plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning and the main ingredient in curry powders. Ground Turmeric is also the source of Curcumin, an extracted potent substance also used as alternative medicine nowadays.
Turmeric, because of its Curcumin content, has many health benefits to humans. Firstly, Turmeric has an anti-inflammatory property. Its active ingredient, Curcumin, has been proven to help reduce inflammation. Decade to decade, Turmeric has been used as an anti-inflammatory agent to treat inflammations of the skin and muscles. Experiments done by researchers also revealed that this herb has been effective in decreasing post-surgical inflammation. This important health benefit of Turmeric is considered to be a result of the herb’s ability to slow down, if not to totally stop, Eicosanoid Biosynthesis, one of the processes the immune system undergoes during an inflammatory response.
Secondly, as a result of its anti-inflammatory characteristic, Turmeric also has an anti-arthritic property. It is widely used as an alternative medicine for rheumatoid arthritis and other autoimmune disorders. In addition, this herb also has a natural painkiller effect. Studies show that it has similar actions to the commonly used medications such as COX-2 inhibitor and Nonsteroidal Anti-inflammatory Drugs.
Thirdly, several studies have shown that Turmeric is also helpful in lowering the level of bad cholesterol in the blood known as the Low Density Lipoprotein or LDL and in increasing the body’s good cholesterol, High Density Lipoprotein or HDL. An increased level of LDL promotes cholesterol plaque deposits to the walls of blood vessels, most commonly in the arteries of heart. These plaques narrow the arterial diameter hence resulting to high blood pressure and even circulation blockage. An arterial block may cause poor circulation and oxygenation to heart muscles leading to cardiac injury then infarction. This is oftentimes the cause of heart attacks. It has also been discovered that Turmeric can promote excretion of dietary fats. Thus, controlling the intestinal uptake of fats, especially cholesterol.
Turmeric - Powerful AntioxidantLastly, Turmeric is also widely used because of its anti-oxidant property. Studies demonstrate that Turmeric is effective in eliminating free radicals in the body. These free radicals are harmful. It may cause cell mutations which can lead to tumor formation and, worse, cancer.
This herbal plant can be prepared in the household by pounding and pressing its roots to be able to extract the juice out. It is then mixed with water and may be used topically or by nasal inhalation. The root can also be lightly cooked and eaten. Turmeric is also helpful in earaches and to clear clogged sinuses thus easing breathing. This herb can also be purchased in bulk powder or standardized forms to ensure its beneficial properties are intact.
September 17, 2009 10:57 AM
Ancient Greeks used hawthorn berries for heart disease. The Greeks and Romans looked to hawthorn as a source of happiness and hope for the future. The berries were used by the Chinese for digestion and circulatory problems. Christian legend says that the crown of thorns that was placed upon the head of Christ was made from hawthorn. The crushed fruit or leaves were used as a poultice for their drawing powers to remove thorns and splinters for centuries in England. Native Americans believed that hawthorn was useful for rheumatism and heart problems.
This herb contains many different components which work together to benefit the heart and body. Hawthorn can both feed and strengthen the heart and arteries. It seems to work on the heart muscle to make it work more effectively. The herb may even help a damaged heart. Hawthorn contains some mild sedative properties, which can help when heart disorders are due to stress and with insomnia. Hawthorn has been used to treat and prevent arteriosclerosis, rapid heartbeat, feeble heartbeat, enlarged heart, angina, and breathing difficulties due to a lack of oxygen in the lungs. Some people recommend using hawthorn to protect against disease before symptoms occur.
Hawthorn is known for its ability to regulate arterial blood pressure. It increases the strength of the heart muscle and also works to increase coronary blood flow. This herb is great in helping to reduce the heart rate and lessen the heart’s workload.
Some studies have found that this extract is responsible for dilating the blood vessels, which results in reduced peripheral resistance. Hawthorn may also have some further cardio-protective effects that become pronounced after prolonged use. Research on 132 patients found substantial positive results with the use of this herb. These stage two stable heart failure patients had improved exercise tolerance, and a reduction in shortness of breath and fatigue after exercise. The researchers noted that for maximum effect, hawthorn must be used for one to two months. Cardiac improvement accelerates with long-term use and relatively high doses. One of the most positive facts about hawthorn is its safety. This herb is believed to be safe for long-term use without side effects. Some experiments have found that hawthorn dilates the blood vessels, lowers blood pressure, and strengthens the heart. This herb is commonly prescribed by German physicians to treat minor heart problems. Hawthorn also contains a mild sedative effect. This effect may contribute to a healthy heart. Stress, anxiety, and nervousness are often associated with heart conditions.
The berries and flowers of the hawthorn plant are used to provide alterative, antispasmodic, astringent, cardio-alterative, diuretic, sedative, and vasodilator properties. The primary nutrients found in hawthorn are choline, inositol, and vitamins A, B-complex, and C with bioflavonoids. Primarily, hawthorn is extremely beneficial in dealing with angina, arrhythmia, arteriosclerosis, high and low blood pressure, heart conditions, heart palpitations, and hypoglycemia.
Additionally, this herb is very helpful in treating arthritis, blood clots, edema, hypertension, insomnia, liver disorders, rheumatism, sleeplessness, and stress. For more information on the many beneficial effects provided by hawthorn, please feel free to contact a representative from your local health food store.
October 09, 2008 01:11 PM
The Indians in South American discovered that the Pau d’Arco tree possesses a lot of medicinal ability in the inner back by observing that the inner bark repelled the insects that flooded other trees in the rain forest. The Indians also found a bush that is found in a certain canyon increased their eyesight, so they named it Eyebright. Similarly, the Arizona Apache and Pima Indians found that if they took a twig of the Chaparral bush and heated it and placed it in or next to a tooth hoe, the pain and infection were relieved.
Because of the above, it can be inferred that man has been using herbs for an extremely long time. This is important, especially when taking it to comparison just how short-term the use of chemicals has been. There is no doubt to anyone that chemical use over a long period of time causes a negative effect on the human body. It seems extremely odd that the scientific community prefers their scientific laboratory experiments with chemicals over 4,000 to 5,000 years of herb use. It seems as if someone would see the inadequacy of trying to find a medicine in laboratories by working with animals over a period of months versus the use of herbs by humans in their natural habitat for thousands of years.
Chemicals are not food for the human body as they have all sorts of negative effects including unwanted immune responses which cause inflammation. They do not provide any nutritional affects. Herbs, on the other hand, are foods that fuel the human body, nourishing it and also cleansing it so that it may be energized. Additionally, these herbs have a lot of unknown positive effects. This seems so simple that some wonder how anyone in a professional status could see the truths in prescribing a drug for their spouse or client. A lot of times it is suggested that patients ask their doctors if they would prescribe the same drug or surgery for their wife or children. We need to become aware of the responsibility we have to our bodies. Many herbs have Glyconutrients and polysaccharides that can feed the immune system. These Glyconutrients or polysaccharides are simple sugars that provide raw materials for the body to build its self better and stronger. Every cell in the body is wrapped with instructions. When the immune system come in contact with each cell, it determines whether its friend or foe. Herbs can help the body build its self better.
Those people who ask if they will become dependant on an herb are thinking of the herbs as a drug instead of food. Although we are dependant on food, it is better to eat food that has been proven to help our body, rather than one which will poison it. Herbs are foods that have proven elements involved which will provide a positive effect on our body. Each specific herb can provide a specific need to our body.
September 10, 2008 09:23 AM
Found growing on trunks or stumps of trees in deciduous forests in temperate climates, the maitake mushroom is native to Eastern Canada and the Northeastern and Mid-Atlantic regions of the United States. Maitake also can be found thriving in northeastern Japan and parts of Europe. With fan-shaped caps on stalks that may be fused together in masses, the mature maitake plant can weight up to twenty pounds. Also called dancing mushroom because of people dancing for joy when they found the maitake mushroom, one legend explains that the name refers to the fact that maitake overlaps other forms of fungi and has the appearance of butterfly wings flapping in a dance.
Only thirty years ago this type of mushroom had yet to become cultivated or well-known. Before 1979 maitake could only be found in the wild. However, now cultivation techniques have made it possible for maitake to be enjoyed all over the world, with some Japanese research finding that it is useful for the healing of a variety of ailments. Maitake is quickly becoming more and more important in the field of natural health. Like other mushrooms, maitake is rich in polysaccharides, which are complex natural sugars that have great benefits in healing as they work to strengthen the immune system to help it fight disease. Beta D-glucan is the powerful polysaccharide that is found in maitake, a compound that helps to stimulate the immune response.
Studies have found that maitake mushroom has the ability to reduce blood pressure in laboratory experiments that took place on animals. A study that was conducted in 1994 at the Ayurvedic Medical Center of New York found that maitake can also be of great value for humans too. This study, which involved individuals who had mild to moderate hypertension, was performed on eleven volunteers. Each volunteer was given three 500 mg doses of maitake twice a day for one month.
The results showed that blood pressure was reduced by 5 to 20 percent. Maitake may also be able to help lower blood cholesterol levels, which is a major factor in fighting and preventing heart disease. Several studies on humans have found impressive results, with three out of four patients with hypertension showing reduction in blood pressure after taking three to five grams of maitake each day.
Maitake also contains properties that are able to protect the liver from damage and even potentially reverse the damage that has already occurred. Demonstrating a hepato-protective effect, maitake works against toxins and potential liver damage. It has also been found to help protect the liver from harmful effects of hepatitis, as a group of thirty-two chronic hepatitis-B patients were studied. Each patient was give maitake extract, with the results showing that 72 percent recovered while only 57 percent of the group the used traditional therapy recovered.
As cancer continues to be leading cause of death in the western world, Human studies are beginning to find that D-fraction polysaccharides in maitake mushroom can help to treat various types of cancer. D-fraction seems to inhibit carcinogenesis and metastatis. Maitake also seems to help to lessen the severity of treatments that are hard on the body and produce debilitating side effects.
Finally, maitake was also the first mushroom that was found to inhibit the activity of HIV in laboratory studies, as it possesses the ability to kill the HIV virus. It stimulates T-cell action and prevents T-cells from being destroyed by HIV cells. Maitake is valuable for increasing the lifespan of individuals who are infected with HIV, but also there quality of life as it may help to slow the development of AIDS symptoms.
Supplements to Fight Prostate Cancer
July 29, 2007 11:41 AM
Prostate Cancer and Nutritional Supplements
Years of research have discovered that the foods a man chooses to eat (or doesn’t eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of cancer (after smoking-related lung cancers).
Recently, there has been an incredible amount of research and investigation of prostate cancer. Many of these studies have explored the use of certain nutrients to prevent and actually treat prostate cancer. These nutrients, calcium D-glucarate selenium, broccoli, green tea, maitake, and lycopene are powerful prostate cancer fighters. All are available as nutritional supplements that men can take every day as an important part of a healthy diet.
In this issue of Ask the Doctor, we will discuss prostate cancer and how men can actually prevent it with the use of these six nutrients. Plus, if men already have prostate cancer, these nutrients can be an important part of their treatment regimen in fighting their disease.
Q. What does the prostate gland do?
A. The prostate is a gland in a man’s reproductive system. It makes and stores seminal fluid, the milky fluid that nourishes sperm. This fluid is released to form part of the semen. The prostate is about the size of a walnut and it is located below the bladder and in front of the rectum. The prostate actually wraps around the upper part of the urethra, the tube that empties urine from the bladder through the penis.
Q. What are the symptoms of prostate cancer?
A. Early prostate cancer often does not cause any symptoms. However, many symptoms of prostate cancer are also symptoms of other problems with the prostate, such as an infection or benign prostatic hyperplasia, a prostate enlargement associated with age-related changes.
A man who has any of these symptoms should see his health care practitioner for evaluation:
-A need to urinate frequently, especially at night
-Difficulty starting urination or holding back urine
-Inability to urinate
-Weak or interrupted flow of urine
-Painful or burning urination
-Difficulty in having an erection
-Blood in urine or semen
-Frequent pain or stiffness in the lower back, hips, or upper thighs.
Q. Are certain men more prone to get prostate cancer?
A. Age is the biggest risk factor: most prostate cancers occur in men over 65 years of age. A man’s risk for developing prostate cancer is higher if his father or brother has had the disease. African-Americans are at higher risk for the disease. Mechanics, farmers, sheet metal workers, and workers exposed to cadmium have also had high rates of prostate cancer.
Q. How is prostate cancer diagnosed?
A. A man who has any of these risk factors may want to ask his health care professional whether to begin screening for prostate cancer (even though he does not have any symptoms), what tests to have, and how often to have them.
The usual prostate tests include: Digital rectal exam: the doctor inserts a lubricated, gloved finger into the rectum and feels the prostate through the rectal wall to check for hard or lumpy areas.
Blood test for prostate-specific antigen (PSA): a lab measures the levels of PSA in a blood sample. The level of PSA may rise in men who have prostate cancer, benign prostatic hyperplasia (a non-cancerous enlargement of the prostate gland), or an infection in the prostate.
These tests will only determine if there is a problem with a man’s prostate gland. They cannot determine if the problem is cancer. Only a biopsy of a sample of prostate tissue can reveal the presence of actual prostate cancer.
Q. What nutrients help prevent or treat prostate cancer?
A. The prostate health nutrients, calcium D-glucarate, selenium, broccoli, green tea, maitake, and lycopene, each work in unique ways. Some help men’s bodies’ work more effectively some keep cancer cells from growing, while others actually kill prostate cancer cells. Let’s discuss each nutrient and how it works.
It is a troubling fact of modern life that we are continuously exposed to cancer-causing chemicals and toxins. These toxins come in part from contaminants in the food we eat and pollutants in the air we breathe. There are also “natural” toxins that are produced in our bodies. Excess hormones, such as estrogen and testosterone, can cause cancer when they are no longer needed. Cancer causing chemicals not only initiate cancer, but exposure to them can also cause existing cancers to grow bigger, stronger, and more deadly.
Our bodies do a fairly good job of eliminating some of these toxins before they can cause us harm. In the liver, the toxin is bound or attached to a chemical called glucuronic acid. The bound toxin is then excreted in bile and eventually eliminated as a waste product in the stool. However, yet another chemical, an enzyme called glucoronidase, can break this bond between the toxin and glucuronic acid. When this happens, the hormone or toxin is released back into our bodies, capable of causing us harm once more. The longer the toxins and excess hormones are in our bodies, the greater the chances they can make us seriously sick. Scientists have discovered that increased glucuronidase activity in the body is strongly associated with prostate cancer.
Fortunately, scientists have also discovered that a natural substance found in foods, calcium D-glucarate, can greatly reduce the activity of glucuronidase. Calcium D-glucarate helps our bodies keep the harmful toxins and chemicals bound to glucuronic acid. While CDG is found in fruits and vegetables, the amounts may not be sufficient to maintain effective levels to stop beta-glucuronidase. CDG has been shown in many experimental studies to significantly stop prostate cancer growth. Studies have shown that by taking calcium D-glucarate, our bodies and get rid of the toxic chemicals and excess hormones that might stimulate cancer formation.
Selenium is an essential trace mineral fund in the soil. Both plant foods like oatmeal and meats that we eat, such as chicken and beef, contain selenium. How much selenium, however, is difficult to determine. This is because the amount of selenium in soil, which varies by region, determines the amount of selenium in the plant foods that are grown in that soil. Animals, too, will have varying levels of selenium in their muscle, depending on the amount of selenium in their feed. The actual selenium level in the grasses and grains that make up animal feed reflect the amount of the selenium in the soil where they grew.
A major antioxidant, selenium slows down aging, keeps our skin supple, and helps prevent dandruff. Selenium also keeps our blood vessels healthy and protects us from heart disease. However, some of selenium’s most powerful effects are on the prostate gland.
In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. Half of the men were given selenium supplements and half were given a placebo. Researchers, who did know which group got the placebo, watched and recorded the men’s progress. The researchers were amazed to learn that selenium cut the rate of prostate cancer by 63%!
The results of this study were so impressive that it has led to many other studies of selenium and prostate cancer. In fact, researchers at the
Scientists have observed over for a long period of time, that men who eat lots of broccoli have a lower risk of getting prostate cancer. It seems that sulforaphane, a compound abundant in broccoli, is the secret ingredient responsible for this connection. Sulforaphane increases certain enzymes in the body, called phase 2 enzymes, which deactivate cancer-causing chemicals. In lab experiments, prostate cancer cells that were exposed to sulforaphane, the compound inhibited the growth of the cancer cells up to 80 percent.
There is a potent plant substance in green tea that is a very effective killer of prostate cancer cells. A recent study tested four common components of green tea and determined that one of these compounds, epigallocatechin gallate or EGCG, has a special affinity for prostate cancer cells. Scientists discovered that EGCG can stop the growth of prostate cancer dead in its tracks. The chemical structure of EGCG is very similar to substances in red wine and cruciferous vegetables, known cancer killers.
For many years, maitake mushrooms have been linked to good health in those who eat them. Called “dancing mushrooms” (possibly due to their wavy, rippling appearance or possibly due to the little dance of joy mushroom hunters perform when they find them in the woods), maitakes contain an important compound called D-fraction.
A recent study at
Some of the most exciting nutritional news in relation to prostate health involves lycopene. This carotenoid is found primarily in tomatoes, and men who eat lots of cooked tomatoes have very low rates of prostate cancer. Because promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, there has been an explosion of lycopene and prostate cancer studies.
In one of these studies, 32 prostate cancer patients ate a pasta meal covered with three-fourths cup of tomato sauce every day for three weeks. Results showed their PSA levels dropped two points. Even signs of DNA damage dropped sharply. The ability of lycopene to drop these levels in just three weeks has impressed researchers and scientists worldwide.
Q. Do I have to take each nutrient separately?
A. While you can purchase each one of these nutrients and take them separately, all of these nutrients are available in prostate health formulas. Make sure the formula you buy contains calcium d-glucarate, lycopene, and selenium, broccoli standardized to contain a minimum of 125 mcg sulforaphane, green tea, and maitake mushroom extract. Standardized ingredients provide consistently effective nutrients.
Q. What else can men do to prevent prostate cancer?
A. Adopting a healthy diet, including eating 5 to 9 servings of fruits and vegetables every day, eating several servings of whole grain cereals and bread, and reducing red meat consumption to 2 or 3 servings per week has been shown to reduce the risk of all kinds of cancer. In addition, the recent lycopene studies suggest that a diet that regularly includes tomato-based foods may help protect men from prostate cancer.
Men 50 years and older should have a digital rectal exam (DRE) and PSA test each year. African-Americans and those at higher risk should begin at age 40. Talk with your health care professional to determine how frequently the test should be done.
This year doctors expect to find 180,000 new cases of prostate cancer is the
More cancers are caught early and new treatments might help make it possible for men to live long and healthy lives following their diagnosis. By taking a few simple steps, men diagnosed with prostate cancer can take charge of their lives and overcome much of the fear and anxiety that accompany a cancer diagnosis.
What can we do about it?
June 26, 2007 02:01 PM
The answer to this problem is amazingly simple. It’s called remineralization. “Remineralization is important because we are missing the minerals and trace elements in our food that should be there,” says Joanna Campe, president of a non-profit organization called Remineralize the Earth. “We can address this by returning minerals to the soil just as the earth does. The natural formulation of soil occurs through the recycling of organic matter, the crushing of rocks onto the earth’s soil mantle by glaciers, and volcanic eruptions that add minerals to the soil. We can add these minerals back ourselves and create fertile soils.”
Remineralized soils can provide two to four times the yield of current unhealthy soils, and greatly increase the health of plant biomass—a well-validated fat that even amazed a group of missoouri high-school students who, in conducting experiments with remineralization, watched pecan plants germinate 7-9 days earlier and grow consistently faster than non-mineralized plants.
Remineralization is also fundamental in solving global warming. “When forests are unhealthy and dying off, they release carbon dioxide into the atmosphere,” Campe says. “When they’re healthy, they store carbon.” And remineralization’s effects are already being felt in this area. Highly successful remineralization on trees has been done by Dr. Lee Klinger, an independent northern California scientist. In the last three years his methods have been used on more than 5,000 Californian oak trees afflicted with malnutrition and other disease conditions, with all but a handful responding with a flush of healthy canopy growth (see www.suddenoaklife.org).
Additionally, there are early-stage studies indicating that spreading rock dust can help bind up atmospheric carbon in the soil and contract global warming.
This sour Indian fruit can have a sweet appetite-stifling effect
May 26, 2007 05:44 PM
Stay satisfied with garcinia
This sour Indian fruit can have a sweet appetite-stifling effect.
It’s funny how modern science continues to support ancient systems of herbal healing. Such is the case with garcinia: the yellowish, pumpkin like fruit of the Garcinia cambogia tree, log valued in tropical Asian cooking for its sweetly acidic taste, is a traditional Indian remedy for digestive problems that is also used to make meals more filling. Today, garcinia (also known as brindleberry and Malabar tamarind) is used in natural weight-loss products based on research supporting its stomach satiating powers. Scientists also believe that garcinia helps block fat formation and regulate glucose (blood sugar) usage vital functions in an increasingly overweight world.
Filling up Faster
One reason so many people losing the battle of the bulge is that temptations to eat – and eat – are absolutely everywhere, often as the focal points of clever and well designed advertising campaigns. (Remember the slogan “belch’a can’t eat just one”?) To make matters worse, restaurants often serve overly generous portions and experiments have shown that the more food you serve, the more people will consume. For example,
The answer would seem simple – just eat less. But knowing when to say when isn’t easy. That’s where garcinia comes in, specifically an extract taken from the rind called HCA (Hydroxycitric acid). In laboratory animals HCA has upped levels of serotonin, a brain chemical that helps suppress appetite and elevate mood, which might help take the edge off the depressing and binge-eating urges that often affect would-be weight losers. At the same time HCA appears to reduce levels of another substance in the brain called neuropeptide Y, which enhances appetite (Experimental Biology meeting 4/06).
What is it: the pumpkin-like fruit of the garcinia cambogia tree; this Indian native is used in cooking and in Ayurveda, the country’s system of traditional medicine.
What is does: A popular ingredient in natural weight-loss aids, garcinia is being investigated for possible fat blocking and appetite-suppressing functions; it may also help regulate glucose (blood sugar).
Fat Smack down
The fat that stubbornly clings to your frame doesn’t always start out that way. In many cases, your body actually creates fat from excess carbohydrates (such as the icing encrusted doughnut you couldn’t pass u at breakfast). If you don’t burn off those extra carbs through exercise, they are broken down into citrates that are then transformed into the building blocks of body fat. This process is controlled by an enzyme called citrate lyase; HCA interferes with this crucial enzyme, an action that inhibits fat formation. Researchers believe the body uses those extra carbs to provide more energy; this mechanism may also have the happy side effect of further checking appetite. In addition, results from a Dutch lab study indicate that garcinia may blunt sugar-induced increases in glucose, which can help forestall diabetes development.
Garcinia works best when teamed with out nutrients and herbs, such as chromium, green tea and forskolin. In one investigation, over weight people who stuck to a supervised diet and exercise program supplemented with a combination of HCA, chromium and another herb called Gymnema lost body weight and mass, and showed improved fat burning capacity (Nutrition Research 1/04). This modern usage mirrors Ayurveda’s ancient precepts, according to which individual remedies are generally used in combination for more effective results. Looking to get your meals more staying power? Then look for garcinia in your favorite weight loss formula. –Lisa James
Breast Cancer and Natural Supplements
May 11, 2007 10:47 AM
Breast Cancer and Nutritional Supplements
There is probably nothing more frightening for a woman than the discovery of a lump in her breast. Cancer and all its consequences quickly come to mind. This quick association may materialize, in part, because no woman is immune. Most have a friend, a sister, a mother, or a coworker who has been diagnosed with the disease. And they know how difficult dealing with this disease can be. Fortunately, 80% of all breast lumps are not cancerous. Most are cysts or a benign clump of tissue.
Over her lifetime, a woman’s breasts undergo many, many changes. From before puberty and on, breast tissue is continually evolving. Breasts often feel different before menstrual cycle, returning to normal a few days after. Pregnancy certainly causes changes in a woman’s breasts, as does breastfeeding. And as women age, breast tissue becomes less dense.
Because of these continual changes, breast tissue especially requires adequate nutrition. While everyone benefits from a healthy diet, there are additional nutrients from which women can specifically benefit.
In this issue of Ask the Doctor, we will discuss breast cancer and the vast amount of research that has explored the role nutrition plays in this serious and still deadly disease. Specifically, we will discuss how two B vitamins, calcium D-glucarate, broccoli extract, green tea, maitake mushrooms, and iodine can all help prevent breast cancer.
Q. How can these nutrients prevent breast cancer?
A. Scientists learn a lot about disease from simply observing what is happening around them. One observation that has been recognized for many years is that certain cultures have very low incidence of breast cancer. Women n
Moms (and dads) have also learned a lot about diseases simply by observing what is happening in their families. They have notices that certain vegetables play a large role in the prevention of all types of diseases, including cancer. And, accordingly, they have been urging their offspring to eat their vegetables for several generations.
Building on these observations, scientists have designed and carried out many studies to determine what it is about these nutrients that can prevent breast cancer. What they have discovered, so far, follows. Let’s start with the B vitamins.
Deficiencies of this vitamin can result in a serious type of anemia. Nerve damage can also occur if B12 levels are too low. Researchers are now investigating whether breast cancer may, in part, be caused by a B12 deficiency as well.
Another study, this one taking place in a laboratory setting, discovered that vitamin B12, applied directly against experimental breast cancer cells, actually stopped the cancer cells from growing. The researchers conducting the experiment believe that giving vitamin B12 to women with breast cancer as part of a chemotherapy regime, might help keep the cancer in check.
Low folic acid intake is linked to the development of all cancers. This is because folic acid is crucial to the making and continual repair of DNA, the molecule that carries our genetic code. A recent study discovered that high intakes of folic acid might actually reduce the risk of breast cancer. The researchers looked at the diets of over 2600 women. During interviews with the researchers, the women reported what they usually ate. Once the data was collected, the results showed that women, who ate lots of foods that contained folic acid, had much lower rates of breast cancer.
There is no clear-cut, single cause of breast cancer. Many factors are required for the disease to appear. One such factor is estrogen. A recent study showed that women who developed breast cancer tended to have higher levels of estrogen circulating in their bodies than women without breast cancer. This means that women who got their periods before age eleven or entered menopause after age fifty-five have a higher risk of breast cancer. This also supports the theory that the number of menstrual cycles a woman has affects her risk for breast cancer.
Another factor is drinking alcohol. Because alcohol raises estrogen levels, if a woman consumes even moderate amounts of alcohol her risk of breast cancer also is increased. The link between alcohol and breast cancer may even be stronger than other dietary links. However, an important study has discovered that folic acid may uncouple this link.
A very large study of over 34,000 women recently studied the effect of folic acid on the risk of breast cancer. This project was part of the Nurses’ Health Study, an ongoing, long-term study that looks at nutrition’s role in the development of disease. The women in the folic acid and breast cancer study were followed for 12 years. The participants completed detailed food questionnaires that provided the researchers with important data.
The women were divided into four groups:
<![if !supportLists]>1. <![endif]>Women with low folic acid levels and drink alcohol
<![if !supportLists]>2. <![endif]>Women with high folic acid levels and rink alcohol
<![if !supportLists]>3. <![endif]>Women with low folic acid levels and don’t drink alcohol
<![if !supportLists]>4. <![endif]>Women with high folic acid levels and don’t drink alcohol
Within these four groups the women were further divided into subgroups according to the amount of alcohol they consumed each day and their specific folic acid intake.
The researchers found that women who consumed the lowest amounts of folic acid and drank at least one alcoholic beverage a day had the highest rate of breast cancer. In contrast, women who had high intakes of folic acid and also drank at least one alcoholic beverage a day, had the same rate of breast cancer as the women with high folic acid intakes who did not drink. In other words, women who had high levels of folic acid in their diet erased their alcohol-related increase in breast cancer risk.
It seems estrogen can be both friend and foe. While women need the hormone to soften skin, thicken hair, and fill out hips and breasts, estrogen can also nourish breast tumors, helping them grow bigger, stronger, and more deadly. Thanks, in part, to good nutrition, American women get their periods early and go through menopause alter in life. Women today also have fewer pregnancies; families with one or two children are quite common.
All of these factors increase the time women’s bodies are exposed to estrogen. As we discussed before, longer exposure means increased opportunities for estrogen to cause trouble. It is also a troubling fact of modern life that we are continuously exposed to cancer-causing chemicals and toxins. These toxins come in part from contaminants in the food we eat and pollutants in the air we breathe.
The body does have a system that eliminates some of the excess estrogen and toxic chemicals before they can cause harm. In the liver, they are bound or attached to a chemical called glucuronic acid. The bound toxin or estrogen is then excreted in bile and eventually eliminated as a waste product in the stool.
However, an enzyme called beta-glucuronidase can break this bond between estrogen and glucuronic acid. When this happens, the hormone or toxin is released from its bone, capable of causing harm once more. Increased beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependant cancers like breast cancer.
Fortunately, scientists have discovered that a natural substance found in foods calcium D-glucarate (CDG) can stop the activity of beta-glucuonidase. CDG keeps the harmful estrogen bound to glucuronidase. While CDG is found in fruits and vegetables, the amounts may not be sufficient to maintain effective levels to stop beta-glucuronidase.
CDG has been shown in experimental studies to significantly stop beast cancer growth. And several human trials are currently underway with CDG to determine its capability to decrease the breast cancer risk in women at high risk for the disease.
There are some very interesting connections between breast tissue and thyroid tissue. Iodine is an essential trace element present in a hormone of the thyroid gland and is involved in several metabolic functions. One iodine function is the protection of breast tissue from cancerous cells.
In a laboratory study, researchers exposed breast cancer cells and breast tissue without any cancer to a type of seaweed that contains high levels of iodine. The seaweed killed all of the cancerous cells, yet did not harm the normal breast cells. Japanese women frequently eat this type of seaweed and have very low rates of breast cancer. The study’s researchers believe one reason for this low incidence of breast cancer may be the iodine in the seaweed.
And, for some as yet unknown reasons, women who have thyroid cancer are at higher risk of developing breast cancer. While they are unsure why this happens, researchers are continuing to study this link, and support of healthy thyroid function remains an important consideration.
For quite some time, scientists have observed that cruciferous vegetables, such as broccoli, cabbage, and cauliflower, significantly reduce the risk of disease, including cancer. It seems a phytochemical in broccoli sulforaphane, is one of the chemicals responsible for this beneficial activity. Sulforaphane increases certain enzymes in the body called phase 2 enzymes that deactivate cancer-causing chemicals.
Breast cancer cells exposed to sulforaphane in several lab experiments showed that the compound inhibited the growth of the cancer cells up to 80 percent. Researchers are in the process of setting up clinical trials to study sulforaphane’s effect in women who have breast cancer.
There is a tall amount of research, including finding from the Nurses’ Health Study, that suggest green tea beverage consumption is associated with a lower incidence of breast cancer. In fact, researchers have long noted the low rates of breast cancer in
The active compound in green tea responsible for breast cancer inhibition is epigallocatechin-3 gallate or EGCG. When breast cancer cells are exposed to EGCG in lab experiments, the cells stop growing, lose their ability to replicate, and die.
In a recent study, researchers discovered that drinking green tea prevented the recurrence of breast cancer in women who have previously been diagnosed and treated for the disease. This study involved over 1100 Japanese women. The women who drank green tea every day had very low rates of their breast cancer returning.
For thousands of years, maitake mushrooms have been linked to good health in those who eat them. Called “dancing mushrooms” (possibly due to their wavy, rippling appearance or possibly due to the little dance of joy mushroom hunters perform when they find them in the woods), maitakes contain an important compound called D-fraction.
Not only does the D-fraction in maitake mushrooms stop the growth of cancerous tumors, it also alerts and stimulates immune cells (including macrophages and natural killer cells) to fight the disease. Maitake also inhibits some of the mechanism that promotes metastasis, or spread, of cancer cells in the lymph and bloodstream.
Because of this success, maitake is now being used in clinical trials of women with breast cancer. One study reported significant improvement of symptoms, including reduction of the tumor. The maitake was given to breast cancer patients in addition to standard chemotherapy.
Q. Should these nutrients be used in place of traditional treatment for breast cancer?
A. Absolutely not. None of these nutrients can cure breast cancer. However, they can be a part of a validated plan of treatment. If you have breast cancer, talk to your health care practitioner about these nutrients. Remember, nutritional supplements are just that: supplements to food, medication, and treatment. They are intended to enhance and prevent, not replace.
Despite apprehension in performing self-breast exams, women are very proactive in their health. Yearly mammograms and pap tests have been an important part of their lives for many years, and newer and more accurate diagnoses are emerging. The prevention of health problems in themselves and their families has always been a high priority for women. And for women, nutrition has played an important part of health problem prevention.
Nutritionally speaking, what benefits your breasts benefit your whole body. However, as we have learned, there are specific links between nutrition and developing breast cancer that seem to be fairly strong.
Making a few changes may reduce the risk of developing the disease. The nutrients listed here, vitamin B12, folic acid, calcium d-glucarate, iodine, broccoli, green tea, and maitake mushrooms can be an important part of a woman’s preventative health regimen.
About George’s and Warren Laboratories
April 21, 2007 01:58 PM
George Warren, and independent research chemist in Houston Texas, developed the special processing method that prevents the spoilage with out diminishing the essential properties of the Aloe Vera Plant. This new method completely eliminates the aloins, which gives a bitter taste (and the greenish color) to Aloe Vera juice. He also successfully removed the starches and sugars from the polysaccharide molecular chain and thus George’s “Always Active” Aloe requires no refrigeration, will not spoil in its natural state. This method adds no water, no preservatives, no chemicals of any kind. The finished product looks and tastes like spring water.
In 1965 George Warren began analytical chemical separation studies that led to the development of a procedure for separating aloe vera juice into 34 component parts. At the time plants in a commercial aloe vera field were numbered. Eight leaves from each plant were harvested. Bagged and labeled. The leaves were then chemically analyzed under laboratory conditions. The results of this testing concluded that six distinct groups were found, and for field testing, were designated as aloe plants A, B, C, X, Y, and Z. this procedure was used to analyze over 2,000 aloe vera plants and it was determined that the aloe vera field contained six different types of aloe vera plants. The chemical make-up of each plant fell into one of six aloe plant groups designated. Aloe-X exerted a very pronounced and measurable effect upon the digestive system. The ability of the digestive system to convert food to energy was greatly improved, but only when Aloe-X juice was consumed daily. The other aloe groups (A, B, C, Y, and Z) did not exert this effect. The improved digestion typified only by group X seemed to occur regardless of the type of digestive system. Listed below are Warren’s findings by daily consumption of Aloe-X.
During these animal feed experiments it was noted that in the control group the digestive system was often swollen and the animal’s hide and carcass did not appear to be healthy. In the Aloe-X test group this was very noticeably not the case. In fact, the digestive system, meat, hide and hair all seemed very healthy.
During the seven years of working with the farm animals the Aloe-X plants originally harvested were growing and multiplying. The chemical analysis of each plant-X offspring revealed that they indeed were only Aloe-X plants.
Up to this point, investigators found that aloe vera did not seem to always work. They were hindered by trying to correlate chemical structure to clinical performance. The primary and reasonable deduction for aloe vera not performing consistently was the fact that only Aloe-X had the ability to cleanse the membranes in the digestive system. If Aloe-X was not present in sufficient concentrations then the aloe vera juice did not seem “active” and did not perform.
Also noted was the phenomenal ability of the plant to quickly reduce swelling and bruised, swollen tissue. Thus, it is further hypothesized that Aloe-X exerts a pronounced effect on the digestive system, rejuvenation the tissue system. By making the digestive system work properly the body appeared to be capable of repairing itself and reverting back to a healthy state. Consequently, it is the firm and un-contradicted belief of Warren that allergies, asthma, emphysema, migraine headaches, and digestive problems are improved by Aloe-X through the membranes in the digestive system.
In the early stages of experimentally using Aloe-X, it was noted that other chemical compounds were present which should not be consumed on a regular basis. In fact, the work of the University of California Professor Bruce Ames clearly points out that all plants have their own toxin defense system against predators. Therefore, not all chemical compounds of plants are good for your health. With this thought in mind, standard conventional pharmaceutical chemical engineering principles were used to remove many undesirable components. Aloe vera by nature spoils easily requiring preservatives to be added to most commercial brands to extend the shelf life of the product. This short shelf life has consistently been a problem for the exploitation of the many benefits of this remarkable plant. Thus, in Warren’s products, starches and sugars of the mucopolysaccharide molecular chain have been removed. These starches and sugars act as an energy source for undesirable micro-organisms. Several other components which earlier testing revealed to be undesirable have also been removed. These substances are removed by a proprietary purification and filtering method. Consequently, preservatives are not required. The micro0organisms picked up in the processing and handling are removed immediately prior to packaging. Testing performed by Warren supports its finding that the purification system does not destroy the active components in the company’s aloe products. Such tests, as well as the votes of confidence (indicated by the thousands of humans and confirmed by testing on chickens, pigs, birds, cows, horses, fish, dogs and cats) confirm that findings. Warren has been successful in developing and proving a unique fractional distillation process that allows for capturing the therapeutic benefits of Aloe Vera.
Scientific Method of Evaluating the Effectiveness of Natural Medicines
April 21, 2007 01:57 PM
Author Dale Ericsson, M.D.; Shinian Cao, M.D.; Fred Crawford, Ph.D; Dale Haufrect, M.D. and Tommy E Hall, Jr.; USA
It has been traditionally assumed that long chain mucopolysaccharide and other natural ingredients found in aloe vera are active only in aloe vera are active only in their unadorned and non-modified state. There is little scientific evidence, however, to support this conclusion. In fact, certain isolated components of aloe vera have pronounced specific pharmaco-therapeutic effects. The purpose of this series of experiments is to evaluate this unique method of scientifically evaluating biological and herbal products and to specifically compare fractionally distilled aloe preparation from a traditional ale preparation.
Utilizing the scientific method of white blood cell (T lymphocyte) culture, stimulation and metabolic turnover rates of more than 25 substances it was determined that:
1. the pivotal study had demonstrated that this type of T lymphocyte cell culture metabolic analysis is useful for evaluation the safety and efficacy of a variety of treatments in which there is only antidotal or clinical studies to support the therapeutic effect.
2. This technique of single blinded study has been employed to define the efficacy as well as compare fractionally distilled aloe vera (warren Aloe) and a traditional aloe vera product. Application of this type of blinded study to two different forms of aloe vera showed that the following conclusion may be expressed with certainty.
This data suggest that the fractionally distilled Aloe vera is bio-pharmaceutically active and provides specific changes in T cell cultures when compared to baseline and with natural aloe vera juice.
This information has been condensed. For entire report refer to EXPLORER! For the processional magazine; volume thirteen: number Two: Pages 15-19.
Growing Older, Feeling Better
March 28, 2007 02:15 PM
Growing Older, Feeling Better
Not long ago, when a man turned sixty-five, he became officially old – the best years of his life far behind him. The milestone meant his working days were done and if he was lucky, he might get four or five years to spend as he wished before illness and infirmity set in. It was simply expected and accepted that the older a man got, the sicker he got.
Well, not anymore. Today, a man age 65 is just as likely to be found hiking in the hills, running in a marathon, or even dancing in the streets than rocking in that proverbial front porch rocker. Because it’s becoming more and more evident that the older a man gets, the healthier that man has been.
Eating healthy, exercising, and kicking harmful habits (like smoking) can add years to a man’s life. Aging research is proving over and over again, that we can prevent and delay heart disease, cancer, diabetes, and Alzheimer’s disease – the major causes of disability and death in men over 50.
Now, it’s very true that good clean living from early on is preferable to sixty five years of bad habits and five years of good. But it’s also true that it’s never too late for men to make changes and vow to take better care of themselves. And one of the easiest and most effective ways men can improve their health is the addition of high quality nutritional supplements.
In this issue of Ask the Doctor, we’ll talk about specific dietary supplements that have been scientifically shown to improve the health of men over fifty, prevent the diseases that often strike at this crucial time in men’s lives, and actually slow the aging process.
Q. I just turned 50 and I’d like to begin taking nutritional supplements, but they seem so confusing. Where should I begin?
A. Many men feel the same way. There are literally hundreds and hundreds of nutritional supplements on health food store shelves. Figuring out which supplements provide the best health benefits for a 50+ man can be overwhelming.
The best foundation supplement is a high quality multivitamin. Research is repeatedly finding that even very healthy men who take daily multivitamins can significantly improve their health. In fact, an article published in the Journal of the American Medical Association (JAMA) recommends that all adult Americans take a vitamin supplement. Look for solid doses of vitamin supplement. Look for sol doses of vitamins and especially minerals. Multivitamins designed to be taken once a day are often woefully deficient in calcium, magnesium, and potassium. The only mineral a man should avoid is supplemental iron. Iron should only be in formulas for women prior to menopause. Men over 50 get all the iron they need from food and too much iron can cause health problems.
Look for men’s multivitamins that contain lycopene in the formula. Lycopene is the pigment that makes tomatoes red. The redder the tomato, the more lycopene is present. Numerous studies have shown that when men have high lycopene levels in their blood, they have a much lower risk of heart disease, age-related macular degeneration (a leading cause of vision loss) and prostate cancer.
Other important considerations are antioxidant blends, especially fruit- and tea-derived extracts; ginseng for energy and stamina; and digestive enzymes to aid in absorption and compensate for age-related decreased enzyme levels.
In fact, years of research has shown the foods a man chooses to eat (or not to eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of non-smoking related cancers.
Q. Aside from taking a quality multivitamin for general health, what nutritional supplements prevent and treat prostate cancer?
A. Six vital and all-natural nutrients can prevent prostate cancer from developing and even help fight the disease.
When men are exposed to excess levels of hormones, their risk of prostate cancer increases. A natural substance found in fruits and vegetables called calcium D-glucarate (or CDG), helps men’s built-in detoxification systems get rid of these harmful excess hormones.
This antioxidant has powerful effects on the prostate gland. In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. The researchers found that selenium cut the rate of prostate cancer by 63%!
Green tea is the most widely consumed liquid in the world, after water. Men in
For many years, maitake mushrooms, or dancing mushrooms, have been linked to good health in those who eat them. That’s because maitakes contain an important compound called D-fraction. A recent study showed that maitake D-fraction destroyed 95% of human prostate cancer cells in lab experiments.
Promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, so there has been an explosion of lycopene and prostate cancer research.
Q. What exactly happens to men’s hormones as they get older?
A. Just as women experience significant hormonal changes as they age, so do men. In fact, the term andropause has been used to describe men’s mid-life changes. Similar to menopause in women (where the decline of estrogen causes a myriad of symptoms), andropause in men signals the slow decline of testosterone, the chief sex hormone in men. While estrogen levels decline faster and more abruptly in women than testosterone levels do in men, testosterone decline can cause a number of unpleasant symptoms. These include abdominal weight gain, hair loss, reduced energy and sex drive, heart disease, and prostate enlargement. Whether a man labels these age-related changes as andropause or just the consequences of aging, most men will unfortunately experience some or all of them as their birthdays mount.
Q. So, is there a supplement that can give me the hormone level of a 20 year old?
A. Sadly, no, at least not yet! But there is a nutrient that can help the testosterone in a man over fifty “behave” more like a younger man’s testosterone.
A study that took place at the
The secret of DIM’s prostate cancer prevention is its ability to metabolize estrogen. While estrogen is generally thought of as a “female” hormone, a precise ratio of testosterone-to-estrogen is needed to maintain a man’s healthy sexual response, effective sexual function (erection of the penis and intercourse), strong bones and muscles, viable sperm, and a well-functioning prostate gland. As men enter their fifties, this ratio begins to change.
When men take DIM, however, their estrogen metabolism improves, testosterone metabolism accelerates, and the unwanted conversion of testosterone into estrogen is eliminated. This results in higher testosterone levels, similar to those seen in young men. As a result, DIM may speed weight loss, reduce prostate gland enlargement (benign prostatic hyperplasia or BPH), and help men over 50 feel stronger and leaner.
Some supplements on the market today contain indole-3-carbinol (I3C), a precursor to DIM. However, I3C is unstable and requires activation in the stomach to be converted into DIM. This means I3C must be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach and colon. DIM is by far the preferred supplement.
Q. What is saw palmetto? Does it reduce symptoms of Benign Prostate Hyperplasia (BPH)?
A. Yes it does and very effectively too. Saw palmetto is a small palm tree native to
The prostate gland is about the size of a walnut and is located below the bladder and in front of the rectum. It wraps around the upper part of the urethra and its primary job is the production and storage of semen, the milky fluid that nourishes sperm. BPH is one of the most common health conditions in older men. Half of all men aged 40-60 and more than 90 percent in men over 80 have BPH. BPH causes the prostate gland to enlarge, putting pressure on the urethra.
Men have trouble starting or maintaining a stream of urine, find they can’t completely empty their bladders, and have to urinate frequently, even during the night. They may also have episodes of uncontrollable dribbling or complete loss of urine. BPH is caused by the conversion of estrogen to a very potent form of testosterone called, dihydrotestosterone (or DHT). When prostate cells are exposed to DHT, they multiply in number and get much larger.
BPH rarely improves. It most often remains the same for years or gets gradually worse. The need to continually urinate, interrupted sleep, dribbling, and loss of urine can significantly interfere with a man’s quality of life. Prescription medications that have been developed to treat BPH are only partially effective. And surgical removal of the prostate gland may result in even more persistent urinary incontinence and the inability to achieve an erection (ED).
However, saw palmetto berry extract relieves the symptoms of BPH by inhibiting the production of DHT. And, in study after study after study, saw palmetto caused none of the side effects that happen with prostate surgery or medications.
Q. There seem to be plenty of ads for supplements that claim they make men into Sexual Superheroes. Is there an “honest” nutritional supplement to help me sexually?
A. That’s a very good observation. And yes, there are honest nutritional supplements for men’s sexual health.
Sexual intimacy is an important, complex, and lifelong need. It makes us feel better physically and mentally and adds to our sense of security, belonging, and self-esteem. But just like other changes that happen to men as they get older, men’s sexual response most often changes, too. Declining testosterone levels, changes in blood flow to the penis, certain medications that older men are prescribed, and the presence of diabetes or heart disease can all affect men’s ability to engage in sexual activity.
When men have a chronic inability in obtaining and/or maintaining an erection, it’s called erectile dysfunction (ED). While ED is not an inevitable part of getting older, it does occur more frequently as men age. About 5% of 40-year-old men have ED, but more than 23% of 65-year-old men have difficulty maintaining erections.
The development of prescription medication Viagra (sildenafil citrate) has revolutionized ED treatment. When a man is sexually stimulated, Viagra helps the penis fill with enough blood to cause an erection.
Like all medicines, Viagra can cause some side effects, including headache, flushing of the face, and upset stomach. But because Viagra is a prescription medication, it requires a visit to a licensed healthcare practitioner. For many men, telling anyone (even a professional) that they are having trouble getting or keeping an erection is simply too embarrassing. Viagra is also fairly expensive and many older men do not have prescription drug health insurance.
These reasons may explain that while an estimated 30 million men in the United States – 10% of the male population – experience chronic ED, as few as 5% of men with chronic ED seek treatment.
Not every man can take Viagra, either. Men who use nitrate drugs, often used to control chest pain (also known as angina), must not take Viagra. This combination can cause their blood pressure to drop to an unsafe or life-threatening level. Men with serious liver and kidney problems who take Viagra must be monitored closely for possible serious side effects.
The good news is there is a nutritional supplement that’s formulated with vitamins, herbs, and glandular products that targets male sexual organs. The formula contains vitamin E, liver fractions, wheat germ, beta-sitosterol, and herbal extracts of muira puama, Mexican damiana, saw palmetto, cola nut, ginseng, and ginkgo biloba.
Vitamin E is a powerful antioxidant and men’s testicles, adrenal glands, and pituitary glands need high levels of this fat-soluble vitamin for proper functioning. Extracts of Muira puama, Mexican damiana, and cola nut have been studied for their beneficial effects on male hormones.
Study of ginkgo in sexual response came about when a patient in a nursing home who was taking the herb for memory enhancement noted that his erections were improved. Since then, study of ginkgo has shown it helps blood flow to the penis. Sexual response research in one ginkgo study showed that 76% of men taking ginkgo experienced improved sexual desire, erections, and orgasms.
While other nutritional supplements sold to improve sexual stamina often make outrageous claims, reputable manufacturers rely on science and results to sell their products.
An important note
Most often sexual problems are simply part of the aging process. They can also be signs of serious health problems. If the use of nutritional supplements for two months does not improve your erections, you do need to see your healthcare practitioner. Almost all practitioners understand how difficult this problem is for men to discuss and are experienced in getting the information as quickly and as painlessly as possible.
No man has the power to stop the passage of time. But every man has the power to make aging more healthy and less harmful. Research conducted on men who live to be 100 and beyond, has determined that those who reach extreme old age do so by avoiding ill health, rather than by enduring it. As I like to remind my patients, “Age is not determined by years, but by function.” And it’s never too late for men to detour around the major illnesses of getting older. With good nutrition, healthy habits, and high quality nutritional supplements, the best years of a man’s life can absolutely and positively be those he spends in his 70s, 80s and even his 90s.
This is sour Indian fruit can have a sweet appetite stifling effect.
January 13, 2007 02:44 PM
It’s funny how modern science continues to support ancient systems of herbal healing. Such is the case with Garcinia: The yellowish, pumpkin like fruit of the Garcinia Cambodia tree, long valued in tropical Asian cooking for its sweetly acidic taste, is a traditional Indian remedy for digestive problems that is also used to make meals more filling. Today, Garcinia (also known as brindleberry and Malabar tamarind) is used in natural weight-loss products based on research supporting its stomach satiating powers. Scientists also believe that Garcinia helps block fat formation and regulate glucose (blood sugar) usage—vital functions in an increasingly overweight world.
Filling Up Faster
One reason so many people are losing the battle of the bulge is that temptations to eat-and eat—are absolutely everywhere, often as the focal points of clever and well designed advertising campaigns. (Remember the slogan “belch’a can’t eat just one”?) To make matters worse, restaurants often server overly generous portions and experiments have shown that the more food you serve, the more people will consume. For example, Chicago moviegoers ate 45% more popcorn from larger containers even when they were given stale product (Food Quality and Preference 1/01).
The answer would seem simple—just eat less. But knowing when to say when isn’t easy. That’s where garcinia comes in, specifically an extract taken from the rind called HCA (Hydroxycitric acid). In laboratory animals HCA has upped levels of serotonin, a brain chemical that helps suppress appetite and elevate mood, which might help take the edge off the depression and binge-eating urges that often affect would-be weight losers. At the same time HCA appears to reduce levels of another substance in the brain called neuropeptide Y, which enhances appetite (Experimental Biology meeting 4/06).
What it is: the pumpkin-like fruit of the Garcinia cambogia tree; this Indian native is used in cooking and in Ayurveda, that country’s system of traditional medicine
What it Does: A popular ingredient in natural weight-loss aids, garcinia is being investigated for possible fat blocking and appetite suppressing functions; it may also help regulate glucose (blood sugar).
The fat that stubbornly clings to your frame doesn’t always start out that way. In many cases, your body actually creates fat from excess carbohydrates (such as the icing encrusted doughnut you couldn’t pass up at breakfast). If you don’t burn off those extra carbs through exercise, they are broken down into citrates that are then transformed into the building blocks of body fat. This process is controlled by an enzyme called citrate lyase; HCA interferes with this crucial enzyme, an action that inhibits fat formation. Researchers believe the body uses those extra carbs to provide more energy; this mechanism may also have the happy side effect of further checking appetite. In addition, results from a Dutch lab study indicate that garcinia may blunt sugar-induced increases in glucose, which can help forestall diabetes development.
Garcinia works best when teamed with other nutrients and herbs, such as chromium, green tea and forskolin. In one investigation, overweight people who stuck to a supervised diet and exercise program supplemented with a combination of HCA, chromium and another herb called Gymnema lost body weight as mass, and showed improved fat burning capacity (Nutrition Research 1/04). This modern usage mirrors Ayurveda’s ancient precepts, according to which individual remedies are generally used in combination for more effective results.
Looking to give your meal more staying power? Then look for garcinia in your favorite weight loss formula. –Lisa James.
Benefits - Supports joint function and tissue health*
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.
Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3
Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3
Promotes optimal joint comfort, function and flexibility*
Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4
Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7
Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8
Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11
Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.
Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*
Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14
Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.
Sustained Release – For lasting joint comfort and convenient dosing
To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.
Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.
3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.
4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.
7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.
8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.
9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.
10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.
11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.
12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.
13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.
14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.
15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
Perplexed about Protein? immunoglobulins to boost the immune system.
April 29, 2006 01:58 PM
The Wellness Revolution
Perplexed about Protein?
As protein and whey powders have advanced in popularity, the confusion about them has grown. In particular, protein processing technology has advanced by leaps and bounds; consumers are being presented with protein claims and counter-claims that are highly contradictory.
The confusion is part of a rapid growth. Little Miss Muffet’s quiet dish of curds and whey has expanded from a minor sideline aid for weight lifters, with sales increases around to percent a year, into an explosive $1 billion a year industry, with some companies announcing sales growth of 110 percent in just the last year.
The increase in market is from whey’s expanding appeal. As new technology has made whey’s nutritive value beneficial to a wide range of consumers, more people are using whey, and whey is being added to more products. The problem is, those advanced nutritive qualities are not included in all whey products. The fantastic immune benefits, for example, apply to only the top tier of whey products.
The standard of protein quality—the ability to provide indispensable amino acids—is judged on the basis of digestibility, nutrients, and amino acid composition. Whey has historically been acknowledged as on of the best sources of high quality protein.
With the increasing popularity of whey, attention on new processing methods has raised the bar on quality, and new products have greatly expanded nutritional values. What may have been an acceptable high-quality whey protein a few years ago, no longer makes the grade. Tony Lucchesi, Natural Sales Trainer at Source Naturals says, “The different processing methods have changed the entire protein market.”
He explains, “In separating casein from whey, (a process used to make cheese), most processing methods use heat, chemical modification, or pH adjustments. These all damage the native protein structure. The result is little or no biological activity in the whey product. All the low temperature drying and micro-filtration won’t help if the raw material is denatured before a protein is dried and brought to market.”
Damaged protein may have been acceptable a few years ago, but it isn’t now. Lucchesi continues, “Animal experiments have shown that polypeptides—whole, non-denatured proteins—have greater nutritional value than protein isolates.”
Protein isolates are what is left after the pasteurization process. The protein has traditionally been “Cross cooked” out of its normal balance. “What you have left are incomplete bits and pieces of whole protein,” he says. These protein bits have only partial nutrients.
The latest introduction to the protein category are concentrates, which are intact, biologically-active whole proteins. The entire difference is in the processing; high heat, acids, and traditional methods of separating the caseins from the whey are no longer used. The new processing preserves the nutrients of the protein. This is the method that is the basis for a new Source Naturals whey product, True Whey.
Lucchesi says, “TRUE WHEY is different in that it was designed to provide nutritional support for enhanced immune function. The entire process was designed for nutritive value. The preservation of these nutrients—lactoferrin, glutamine, immunoglobulins—give TRUE WHEY a huge benefit to athletes, children, and anyone interested in boosting their immune system.”
Per serving, TRUE WHEY offers 8 grams of un-denatured protein that includes 900 mg immunoglobulins and 190mg of lactoferrin. Its vanilla flavoring has gotten very high reviews, and it has a two-year shelf life. It appears that the bar has truly been raised in the whey protein category!
Benefits of L-Carnitine
February 12, 2006 03:24 PM
A Medical History
February 10, 2006 06:39 PM
Curcumin’s antioxidant powers are the common thread connecting the many health benefits and therapeutic virtues attributed to turmeric spice in the Ayurvedic medical tradition of India. Curcumin is the subject of numerous test-tube studies and animal experiments demonstrating various effects linked to reduction of free radicals and control of free radical based abnormalities. Preliminary human trials bolster these findings, suggesting Curcumin helps keep joints soothed and flexible, while protecting cells and tissues from free radical attack.
Pomeratrol™ Fact Sheet
December 19, 2005 09:09 AM
Pomeratrol™ Fact SheetNeil E. Levin, CCN, DANLA 9/28/04
USER: Those needing antioxidant protection; People with a family history of cell growth abnormalities; Anyone concerned with aging
KEY INGREDIENT(S): Pomegranate fruit standardized extract 200 mg. (Punica granatum) containing 80% total polyphenols, including 40% Ellagic acid, Resveratrol (100% trans-resveratrol) 20 mg. from a blend of Japanese knotweed root extract (Polygonum cuspidatum) and grape skin extract (Vitis vinifera)
POTENTIAL BENEFITS: Ellagic acid is a polyphenol compound found in raspberries, strawberries, pomegranates, and other fruit. It has been shown to normalize cell death of abnormal cells, a process called apoptosis. This enhances the body’s cell growth control system by providing an important plant substance. It may bind to DNA to prevent damage to this all-important genetic material. This is a key step in preventing cell damage that leads to signs of aging.
The American Cancer Society says that research in animal and laboratory models has found that ellagic acid inhibits the abnormal growth of certain cells. Research at Ohio State University indicates that berries typically contain a few milligrams per ounce of ellagic acid, the actual level varying quite a bit from variables such as species, variety and growing conditions.
Resveratrol is an antioxidant compound that is a phytoestrogen, or plant estrogen, which is protective of hormone-mediated cells in the body. Resveratrol is a potent antioxidant if stabilized. If not stable, it may quickly metabolize out of the body. This compound is believed responsible for some of the beneficial effects of moderate red wine drinking on the cardiovascular system. Resveratrol is also considered to be beneficial to smokers’ lung tissue if it is stabilized to last long enough in the system to be transported there. Resveratrol is also an inhibitor of the COX-2 inflammatory enzyme and encourages cell death (apoptosis) of abnormally growing cells. In insect experiments resveratrol even repaired DNA, leading to a longer life for healthy cells even as it helped get rid of unhealthy cells. Again, this ability to protect cells and help the body rid itself of abnormal cells is a key factor in preventing signs of aging. One liter of red wine contains between 1.5 and 3 mg. of resveratrol.
OTHER IMPORTANT ISSUES: Resveratrol is a difficult substance to stabilize. Because of the difference between resveratrol produced in the oxygen-poor environment in red wine and the form of resveratrol in unstabilized supplements, it has long been thought that resveratrol supplements were not very effective in comparison with wine. Knowing the importance of how a resveratrol supplement is metabolized, Now’s scientific staff has recently developed a special technique of stabilizing this compound in order to have an antioxidant effect closer to drinking a good glass of wine. While both trans and cis forms of resveratrol are naturally occurring, most of the recorded health benefits are attributed to the trans form. Now’s Pomeratrol provides trans-resveratrol.
DOSE: One capsule per day. Resveratrol has been used safely in studies at doses equivalent to 500 mg./day.
COMPLEMENTARY PRODUCTS: Other antioxidants and plant compounds: Vitamin C, pycnogenol, grape seed extract, and alpha lipoic acid.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. There are some indications that resveratrol is a mild anticoagulant ("blood thinner"), and it also may help keep blood vessels to remain open and flexible. Caution should be used by those on blood-thinning drugs. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Comprehensive Prostate Formula-the Clinical Studies
October 13, 2005 04:32 PM
Helps maintain a healthy prostate gland.
Supports normal urinary function.
Comprehensive Prostate Formula-the Clinical Studies
Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.11,12,13 For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months.1 The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate.
The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT.14 Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells.15 The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions.14,16 These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. Clinical studies have used extracts containing 85 to 90 percent fatty acids and sterols.
Like Saw palmetto, Pygeum contains natural sterols and fatty acids.2 Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation.17,18 In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.19
Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract.20 As far back as 1950, German investigators have observed favorable effects on the prostate with the use of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a recent double blind study published in the journal Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days.3 Urination was significantly improved.
L-Alanine, Glutamic Acid and Glycine
As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and glycine has a positive effect on prostate-related urinary function.5 A controlled study of 45 men was conducted to follow up on these initial observations.21 The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency.
2. Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and Comparisons, St. Louis, MO.
3. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clinical Therapeutics 1993; 15(6):1011-19.
4. Wagner, H., Willer, F., Samtleben, R., Boos, G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots Phytomedicine 1994; 1:213-224.
5. Feinblatt, H.M., Gant, J.D. Palliative treatment of benign prostatic hypertrophy. Journal of the Maine Medical Association, March 1958:99-124.
6. Giovanni, E., et. al. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995;87(23):1767-76.
7. Wallace, A.M., Grant, J.K. Effect of zinc on androgen metabolism in the human hyperplastic prostate. Biochemical Society Transactions 1975; 3(3):540-42
8. Badmaev, V., Majeed, M., Passwater, R. Selenium: A quest for better understanding. Alternative Therapies 1996; 2(4):59-67.
9. Fouhad, M.T. Selenium and cancer, chromium and diabetes: two trace elements that have merits as dietary supplements in human nutrition. Journal of Applied Nutrition 1979:31(1&2):14-17.
10. Vescovi, P.P., et. al. Pyridoxine (Vit. B6) decreases opoids-induced hyperprolactinemia. Horm. metabol. Res. 1985; 17:46-47.
11. Tasca, A., et. al. Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo. Minerva Urologica e Nefrologica 1985; 37:87-91.
12. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C. Medical treatment of prostatic adenoma. A controlled test of PA 109 vs. placebo in 110 patients. Ann. Urol. 1984; 18(6):407-410.
13. Crimi, A., Russo, A. The use of Serenoa repens extract in the treatment of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983; 4:47-51.
14. NiederprŸm, H.J., Schweikert. H.U., ZŠnker, K.S. Testosterone 5 alpha-reductase inhibition by free fatty acids from Sabal serrulata fruits. Phytomedicine 1994; 1:127-133.
15. Sultan, C., et. al. Inhibition of androgen metabolism and binding of liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J. Steroid Biochem. 1984; 20(1):515-519.
16. Weissner, H., et. al. Effects of the Sabal serrulata extract IDS 9 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. The Prostate 1996;28:300-06.
17. Yablonsky, F. Nicolas, V., Riffaud, J.P., Bellamy, F. Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. J. of Urology 1997; 157:2381-87.
18. Marconi, M. et. al. Anti-inflammatory action of Pygeum extract in the rat. Farmaci. & Terapia. 1986; 3:135.
19. Barlet, A, et. al. Efficacy of Pygeum africanum extract in the treatment of micturational disorders due to benign prostatic hyperplasia. Evaluation of objective and subjective parameters. A multicenter, randomized, double-blind trial. Wien. Klin. Wocheschr. 1990; 22:667-73.
20. The Complete German Commission E Monographs. 1998, Blumenthal, M., ed., (p.216) Austin, TX: American Botanical Council.
21. Damrau, F. Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. American Journal of Geriatrics 1962; 10:426-30.
October 06, 2005 10:08 PM
Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance .
Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium . An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake . Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.
An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" . The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups . Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium .
In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body . It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys .
Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium . Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.
Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 . The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.
Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.
Magnesium-the Versatile Mineral
The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."
Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP . ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".
Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles .
Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat . Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress . This has been found true even in the absence of an actual magnesium deficit in the body.
Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density . The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men . In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency . While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.
Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes .
A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.
Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption . Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide .
Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 .
Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® .
Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Doctor's Best•1120 Calle Cordillera•Suite 101, San Clemente, CA 92673
Curcumin - Turmeric Extract
August 19, 2005 12:47 PM
Turmeric- History and Traditional Usage
Native to Southeast Asia, Curcuma longa is a tall
In addition to its
Turmeric is named in
Protects cells and tissues by fighting free radicals.*
Supports joint function*
The numerous beneficial
Animal studies- In vivo protective effects
Through its free radical scavenging
Curcumin exhibits free-radical scavenging ability when
Bioperine-Nature’s Absorption Enhancer
Traditional Ayurvedic herbal
Curcumin is poorly absorbed in the intestinal
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
PYCNOGENOL - ITS REMARKABLE BENEFITS
July 13, 2005 12:26 PM
PYCNOGENOL - ITS REMARKABLE BENEFITS
New to North America but not to Europe, this natural product is considered safe and effective in the treatment of various diseases and for the maintenance of optimal health. This family of bioflavonoids is non-toxic, water soluble and highly bioavailable. Because proanthocyanidins scavenge free radicals so effectively, they have shown remarkable curative effects. Extensive research demonst rates that proanthocyanidins are such potent antioxidants, they find and neutralize free radicals with great rapidity, allowing cells to regenerate rather than deteriorate. Specific actions associated with Pycnogenol include:
PYCNOGENOL SPECIFICALLY TARGETS: SKIN AND ELASTICITY
Testing has suggested that Pycnogenol flavonoids exhibited an anti-enzyme effect which prevented the break down of collagen and elastin, the very compounds which keep skin firm and inhibit the formation of wrinkles.7
TUMOR RELATED DISEASES
Unquestionably, studies have shown that Pycnogenol has the ability to inhibit cellular mutations.8 The implications of this finding for anyone suffering from tumor related disease which originates from cellular malfunctions should not be underestimated.
The potential of Pycnogenol to pr e vent cellular deterioration or uncontrolled growth is profound to say the least. Several investigations have shown that if it is taken on a daily basis, Pycnogenol benefits people suffering from cardiovascular diseases and breast tumors.9 In addition, double blind placebo controlled studies have indicated that patients suffering from circulatory insufficiencies and diseases of the lymph system showed significant improvement in pain control and vessel elasticity after taking these flavonoids.10
Subsequent experiments concluded that the family of bioflavonoids contained in Pycnogenol is capable of improving night vision and initialing “a rapid and marked improvement of visual performances after glare in comparison with control group.”11
WATER RETENTION AND EDEMA
Pycnogenol is particularly valuable for anyone who suffers from water retention and edema. Studies at the Institute of Physiology at the Bulgarian Academy of Sciences confirm that this biofl avonoid compound stabilized capillary walls, which decreased fluid leakage into tissues which causes swelling and pressure.12
WHAT PATHOLOGICAL CONDITIONS RESPOND TO PYCNOGENOL?
The bioflavonoids found in Pycnogenol have been clinically indicated in the following pathological conditions:
PYCNOGENOL HAS THERAPEUTIC VALUE FOR THE FOLLOWING CONDITIONS:
PYCNOGENOL CAN CROSS THE BLOOD-BRAIN BARRIER
One of the most significant advantages of this flavonoid compound is its ability to cross the blood-brain barrier. Consequently, it acts as an invaluable therapeutic agent in treating depression, chronic fatigue, insomnia or loss of memory.
ANTI-ULCER FORMING PROPERTIES
Other scientific tests have indicated that proanthocyanidins also posses anti-ulcer properties and may work to prevent the formation of undesirable chemicals in the stomach.13
THE DEADLY DEATHCAP MUSHROOM, SILYMARIN, AND LIVER DAMAGE
July 12, 2005 09:58 AM
THE DEADLY DEATHCAP MUSHROOM AND SILYMARIN
The protective action of Silymarin in the liver has been confirmed through several experimental and clinical studies. Animals who have had their livers exposed to toxic chemicals such as carbon tetrachloride, amanita toxin (deadly mushroom) and galactosamine were protected from damage by Milk Thistle.3 Animals who had their livers partially removed experienced some organ regeneration when treated with Milk Thistle.
In the 1970’s, additional research on the ability of Milk Thistle to de-toxify liver cells of deadly mushro o m poisoning was conducted. The poison of this mushroom is extremely toxic and usually results in death within two to five hours. Amantine causes severe hemorrhagic liver dystrophy and inevitable death. Even when the studies were undertaken, scientists did not expect Milk Thistle to offer any significant protection against such a volatile and deadly toxin. The two peptides which comprise the poison are the most potent liver damaging substances currently known. Sixty patients who had severe amanita poisoning in Europe were treated with Milk Thistle. The results were impressive.
In experiments where silymarin was given before the amanita toxin was ingested, it was 100 percent effective in preventing liver toxicity.4 If given within ten minutes, it still neutralized the poison. Even after 24 hours, it was found to prevent death and liver damage.5
Not only did Milk Thistle protect the liver fro m amantine damage, it also helped to prevent the loss of weight normally seen in animals that have ingested the poison. The impressive results of these tests resulted in stepped up production of Milk Thistle extract, which has made it much more available now.
HAWAIIAN NONI (Morinda citrifolia)
July 11, 2005 08:50 PM
In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.
The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.
Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.
Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.
ROOT AND ROOT BARK
Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.
Body Systems Targeted
The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.
Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.
Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .
NONI: ITS USE AND HISTORY
Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .
Wonder Herb of Island Folk Healers
Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.
Noni’s Medical Reputation
Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.
A Timely Reemer gence
Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.
TRADITIONAL USES OF NONI
Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15
decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI?
One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .
Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18
How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.
MODERN APPLICATIONS OF NONI
Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.
Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.
xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.
A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21
In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.
with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.
The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.
The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.
The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.
While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.
A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29
Skin Healing Agent
One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.
burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30
The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.
Complementary Agents of Noni
PrimaryApplications of Noni
June 29, 2005 05:38 PM
Bio-Chelation* By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt In The Beginning The Bio-Chelated¨ process describes a proprietary cold extraction technique developed by Mr. Frank D'Amelio Sr., founder and owner of Nature's Answer¨, and well- respected author*. Long before Nature's Answer¨ was formed (early 1970's), Mr. D'Amelio was immersed in the study of botanical medicine, researching the various herbal texts including the national USP/N.F. (United States Pharmacopeia/National Formularies) dating back to the mid -1800's. (The USP/N.F. is a reference source that provides manufacturing standards and extraction techniques used to make herbal formulas; these standards were considered official prior to 1938.) This authoritative formulary discussed the use of plant parts such as leaf, stem, bark, flowers and roots. It recommended certain solvents known as "menstruums", in which plant parts were soaked in order to extract their active constituents. High heat was also often utilized to concentrate the extract. Mr. D'Amelio noticed that high amounts of solvents, usually alcohol, were often recommended, and that sediment would fall to the bottom (precipitate) in certain solutions. He began to investigate how he could offer the consumer potent herbal products made with very low heat, with minimum precipitation, and without a lot of alcohol!
A Clue From Nature In working towards the goal of attaining a final botanical extract product with little alcohol, Mr. D'Amelio turned to Nature for the apparent answer. He realized that plants were composed of 80-85% water as well as some alcohols, fats, etc. If plants were able to keep the active constituents in solution and use them as needed mainly through water, not alcohol or other solvents, why couldn't he? Thus, he began a long, in-depth series of experiments with many different plants. Through rigorous research protocols and scientific testing, he discovered that the active constituents of some plants could be extracted using lower alcohol amounts with water and other natural solvents such as organic apple cider vinegar or vegetable glycerine. At other times, however, higher alcohol was necessary, such as when he was extracting volatile oils like menthol from peppermint. The experimentation process continued, with Mr. D'Amelio documenting the optimum menstruum combinations required for each plant to yield the maximum beneficial components. (Note that there are differences in alcohol. The alcohol consumed in wine and beer is derived through a natural fermentation process with no processing other than filtration. When distilled alcohol is added to an extraction, which some herbal manufacturers use, it effects the body in a more detrimental way; thus the development of the Bio-Chelation¨ process, which uses only organic alcohol).
The Bio-Chelated¨ Method Is Developed As Mr. D'Amelio continued his experimentation with various plants and menstruums, his extraction processes became more refined, and eventually led to the development of the Bio-Chelated¨ method. The Bio-Chelated¨ method incorporates soaking for a period of time, using different menstruum ratios for different plants to optimize their therapeutic values. Furthermore, this procedure offers additional significant advantages when compared with other types of extraction processes commonly employed by competitors in the herbal industry.
Bio-Chelation includes the use of "cold extraction", where the plant parts are extracted without being exposed to excessive amounts of heat. Cold extraction helps the herb maintain vital minerals and other trace elements in solution, thus enabling the herb to keep its Holistic Balanceª intact. (Holistic Balanceª means that extracts retain as many of the natural constituents of the original plant as possible.) In addition, the Bio-Chelated¨ process incorporates the use of an exclusive technique that removes much of the alcohol used during the menstruum soaking (maceration) phase, replacing it with vegetable glycerin instead. The resulting yield is an herbal extract that is either alcohol-free, or has a low alcohol content. (Both alcohol-free and low alcohol products from Nature's Answer feature vegetable glycerin only. Glycerin is used because it helps bind certain plant constituents, is natural to the body, is easily absorbed by the cells and has little insulin response. Only vegetable glycerin has been used since 1972. In addition, all alcohol used in Nature's Answer's low alcohol formulas is certified organic.)
The Bio-Chelated¨ method was the first extraction process to yield a 12-14% alcohol extract in the herbal industry!
Nature's Answer Stands The Test of Time Over the last quarter of a century (since 1972), the Bio-Chelated¨ cold extraction process has been painstakingly tested and proven to stand the test of time. Incorporating Mr. D'Amelio's proprietary cold extraction process in today's manufacturing procedures continues to yield a measurably superior product. One such example is Saw Palmetto from Nature's Answer¨, a product that is produced utilizing our Bio-Chelated¨ method versus the more expensive CO2 method. Our Bio-Chelated¨, cold extraction process yields a product that not only contains the same amounts of active constituents as the more expensive CO2 extracted product, but features a higher percentage of polyphenols, the compounds responsible for the herb's antioxidant properties. The end result is a Saw Palmetto extract that maintains its holistic balance! (Note that most prior successful studies done on Saw Palmetto utilized grain alcohol extracts which contained naturally occurring polyphenols; the CO2 extracted products do not contain polyphenols!) Although larger quantities of herbal products are now being produced as compared to the earlier experimental batches made by Frank D'Amelio, his founding corporate philosophy remains intact - combine the greatest care with the highest quality of raw material to create the ultimate herbal extract that works. After all, that's what it's all about, isn't it? Bio-Chelated¨..Another reason to count on Nature's Answer Without Question! Manufacturing Highlights:
State-of-The-Art Laboratory Manufacturing Equipment HPLC, UV, IR, GC/MS, LC/MS, TOC and Densitometer 316 Pharmaceutical Grade Stainless Steel or Glass Lined Extraction Vessels (instead of the inexpensive, more commonly used plastic or polyethylene extraction vessels; these vessels are porous and may contain microorganisms, residual plasticizers that are difficult to clean and could cross contaminate different batches of herbs) FDA Registered & Pharmaceutically Licensed cGMP and SOP Compliant Manufactured in the U.S.A. *Botanicals - A Phytocosmetic Desk Reference (1999), Botanical & Herbal Folklore (1974), The Botanical Practitioner (1978) Bio-Chelated¨ is a registered trademark of Bio-Botanica Inc.¨ Holistic Balanceª is a trademark of Bio-Botanica Inc.¨
Alcohol-Free Herbal Extracts
June 29, 2005 05:20 PM
Alcohol-Free Herbal Extracts By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt
Alcohol: The First Menstruum
Liquid extracts are a time tested, effective delivery system for medicinal herbs. When choosing liquid extracts, read the label. You will usually see that they contain quite a bit of alcohol. Alcohol is used as a menstruum, or solvent that frees all of the constituents from the fiber and cellulose of the plant, so that the specific medicinal constituents we want become more bio-available to the body. Alcohol has traditionally been used as the menstruum of choice because it is one of the most effective solvents (materials used to pull out the constituents of the herb) that is both reasonably priced and not too toxic on the body. Most of the herbal extracts on the market today have an alcohol content between 30 to 70%.
Bio-Chelation: A Revolutionary Concept
In the 1970’s Mr. Frank D’Amelio Sr., CEO and founder of Nature’s Answer®, noticed that the United States Pharmacopeia (the text that was used as a formulary for herbal processing), recommended using high amounts of alcohol to extract active constituents from the plant. He began to wonder how he could offer consumers potent herbal products without a lot of alcohol. One clue from Nature that became apparent to him was the fact that plants themselves were composed of 80-85% water. Since plants were able to keep their active constituents in solution and use them as needed through the use of water, not alcohol or other solvents, why couldn’t he? He began a long, in depth series of experiments with many different plants. Through rigorous research protocols and scientific testing, he discovered that the active constituents of some plants could be extracted using lower alcohol amounts along with water and other natural solvents, such as organic apple cider vinegar. (Conversely, higher alcohol was necessary at times when volatile oils were being extracted such as menthol from peppermint.) The experimentation continued, as Mr. D’Amelio recorded the optimum menstruum combinations required for each plant to yield the maximum medicinal components. He further refined the process, eventually developing the proprietary Bio-Chelation® cold extraction method.
The Bio-Chelation technique describes an exclusive process that removes much of the alcohol used during the menstruum, or soaking phase, and replaces it with vegetable glycerin, yielding extracts that are either alcohol-free, or have a low alcohol content. In addition, the alcohol used in any Nature’s Answer herbal extract product has the further distinction of being ‘organic’.
The Bio-Chelation method yielded the first 12-14% alcohol extract in the herbal industry!
The Alcohol-Free Advantage
There are many reasons why people may not want to use herbs with high alcohol content. Some people dislike the strong taste of alcohol. Alcohol can stress a weakened or under-functioning liver in sensitive individuals, such as those suffering from allergies, environmental sensitivities, systemic candida, and/or a host of other health concerns. Furthermore, people in recovery from alcoholism cannot use alcohol. Finally, alcohol is not appropriate for young children.
Nature’s Answer's alcohol-free extract formulas replace alcohol with natural vegetable glycerin because glycerin helps to bind certain plant constituents and is easily absorbed by the cells. Glycerin occurs naturally throughout the body. It also makes up a portion of the cellular membranes. This gives glycerin an affinity for the body, making it an excellent carrier for herbs. (Nature’s Answer only uses “vegetable glycerin” in their products.) Another advantage of using glycerin over alcohol is that glycerin serves to protect and preserve the potency of the herbal extract in the bottle over the life of the product longer than alcohol would. Since alcohol easily evaporates, it can lose its effectiveness as a preservative for the herbal constituents as the amount of the alcohol in the bottle decreases. Glycerin, due to its viscosity (thickness) aids in maintaining the freshness and potency of the herb for the life of the product. Finally, glycerin has the added advantage of acting as a sugar-free natural sweetener, thus making the taste of some bitter herbs more palatable.
Nature's Answer®, the pioneer of the alcohol-free extraction process, is proud to offer a comprehensive line of both single herb extracts and combination herbal formulas that do not contain alcohol.
June 25, 2005 08:13 PM
1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. 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J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. From Obesity to Diabetes. Pathophysiological Considerations. Int. Journal of Obesity 1992;16:937-952. 34 Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women age 18-79. J Chronic Diseases 1987;40:421-8. 35 Haffner SM, Stern MP, Hazuda HP, et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellits in Mexican Americans and non- Hispanic whites. Diabetes Care 1986;9:153-61. 36 Bonadonna RC, deFronzo RA. Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism. 1991;17(1 Pt. 2):12-35. 37 Shoemaker JK, Bonen A. Vascular actions of insulin in health and disease. Canadian J. of Applied Physiology. 1995;20(2):127-54. 38 Resnick LM. Ionic Basis of Hypertension, Insulin Resistaince, Vascular Disease, and Related Disorders. The Mechanism of ‘Syndrome X’. Am. J. Hypertension. 1993;6(suppl):123S-134S. 39 Trautwein EA. Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. Laeger. 1991;153(13):908-13. 46 Lissner L, Heitmann BL. Dietary fat and obesity: Evidence from epidemiology. European J. Clinical Nutrition. 1995;49(2):79-90. 47 Lissner L, Heitmann BL. The dietary fat: Carbohydrate ratio in relation to body weight, Current Opinion in Lipidology. 1995;6(1):8-13. 48 Ravussin E. Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care. 1993;16(1):232-8. 49 O’Dea K. Westernisation, insulin resistance and diabetes in Australian aborigines. Med J. Australia. 1991;155(4):258-64. 50 Bailey C. Fit or Fat . Houghton Mifflen, Boston, 1991. 51 McCarty MF. Optimizing Exercise for Fat Loss. Unpublished report. 52 Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate and fat-free mass and the the metabolically active components of fat-free mass in humans. Am. J. Clinical Nutrition. 1992;55(4):790-4. 53 Evans WJ. Exercise, nutrition and aging. J. Nutrition. 1992;122(3 suppl):796-801. 54 Schlicker SA, Borra ST, Regan C. The weight and fitness status of United States children. Nutrition Reviews. 1994;52(1):11-7. 55 Raben A, Jensen ND, Marckmann P, Sandstrom B and Astrup A. Spontaeous weight loss during 11 weeks’ ad libitum intake of a low fat/high fiber diet in young, normal weight subjects. Stockholm Press. 1995;916-23. 56 Blundell JE, Cotton JR, Delargy H, Green S, Greenough A, King NA, Lawton, CL. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Short Communication 1995:832-835. 57 Reinhold RB. Late results of gastric bypass surgery for morbid obesity. J Am Coll Nutr 1994;13(4):307-8. 58 McCredie M, Coates M Grulich A. Cancer incidence in migrants to New South Wales (Australia) from the Middle East, 1972-1991. Cancer Causes Control 1994:5(5):414-21. 59 Schiff ER, Dietschy JM. Steatorrhea Associated with Disordered Bile Acid Metabolism. Am. J. Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.
June 25, 2005 08:04 PM
Chitosan is not only very useful, it is also very safe. Chitosan has been used extensively in nummerous industrial, health, and food applications.66,71 Nevertheless, all substances when taken improperly or in gross excess can be detremental to our well-being. For example, water is normally safe when swallowed. On the other hand, breathing large amounts of water can be deadly. Similarly breathing air is relatively safe whereas intraveneous injections of air are usually fatal. To determine the relative safety of various foods, scientists run experiments to determine the food’s toxic level or LD50. Chitosan has been found to have an LD50 of over 16 grams/day/kg body weight in mice.122 Chitosan is a fiber which expands to form a gel in the acidic environment of the stomach. The problems encountered with extremely high doses of chitosan were caused by gastric dehydration and impaction due to the expansion of the fiber.123 To put these data in context, the authors compared Chitosan to common sugars stating “[I]t appears that chitosan is less toxic than these substances.”122 Mice are not men. For safety purposes data gathered in mice is divided by 12 to get the human equivalent.124 The relative LD50 in humans then would be 1.33 grams/day/kg. Given that an average person weighs 150 pounds or 70 kg, this means that the toxic amount for a person would be greater than 90 grams per day. Conservatively, one could feel very confident below the 10% level, or 9 grams per day. Clinical studies have used amounts in the 3-6 grams per day range with no adverse effects. As with any fiber, a person is well advised to drink plenty of water. Changing our diets affects our colon function. Constipation or diarrehea may occur in some persons depending on their individ-ual constitutions and on how well the Chitosan supplement was originally formulated. Even though Chitosan is not digestible by our enzymes, it can and is degraded by soil and water microorganisms. This makes Chitosan environmentally friendly. This was recently acknowledged by the US Environmental Protection Agency when it exempted Chitosan from tolerance level testing.68 Any breakdown of chitosan by our colon microflora would release D-glucoseamine which is itself a wonderfully beneficial nutrient for osteoarthritis sufferers.125 Because Chitosan can bind lipids and certain minerals, it is best to take essential fatty acid supplements, fat soluble vitamins and mineral supplements separate from Chitosan. Taking Chitosan with D- or L-ascorbic acid helps increase the amount of fat bound and decrease the loss of minerals. 77,126
MECHANISMS OF CHITOSAN FAT- BINDING
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MECHANISMS OF CHITOSAN FAT- BINDING
The exact way(s) that Chitosan prevents fat absorbtion is not fully understood but a number of experimental observations support two basic mechanisms. The first mechanism involves the attraction of opposite charges which can be compared to the attraction of opposite magnetic poles. The second entrapment mechanism can be compared to the effect of a net. In the first mechanism the positive charges on chitosan attract the negatively charged fatty acids and bile acids binding them to the indigestible chitosan fiber. This mechanism can explain why chitosan reduces LDL cholesterol levels.
Our bodies make bile acids in the liver using the cholesterol from LDL. When chitosan binds bile acids it increases the rate of LDL loss thus improving the LDL to HDL ratio. If enough bile acids are bound, the fats are not solublized, which prevents their digestion and absorption. The second mechanism (figure 2) describes a netting effect of chitosan fiber.
In this model the Chitosan wraps around fat droplets and prevents their being attacked and digested by lipid enzymes. Fats unprotected by Chitosan are digested and absorbed. The “netting” mechanism has been seen to operate in vivo. 108
Substances that Enhance the Action of Chitosan
Fibers can be likened to a tangled-up chain. Fibers must “unravel” in order for them to be of maximum benefit to us. “Unraveling” is especially critical for chitosan because each link has a hook on which to attach lipids. Chitosan can absorb an average of 4 to 5 times its weight in lipids. Reports of numbers above and below this range have also been reported and may well reflect the rate or extent of unraveling that had taken place. Fiber formulations can be prepared that unravel rapidly and swell quickly. These highly effective formulations are called superabsorbants. When certain substances are added to chitosan, its remarkable fat-binding ability can be significantly enhanced.
D-Ascorbic acid (erythorbic acid) and L-ascorbic acid are C-vitamins which enhance chitosan’s ability to bind lipids. Combining chitosan with ascorbic acid results in even less fat absorption and greater fecal fat losses.77,108 In one study the addition of ascorbic acid to a chitosan enriched diet increased fecal fat losses by 87 percent and decreased fat absorption by over 50 percent.77
Cholesterol oxides cause lesions in artery walls which predispose blood vessels to collect plaque. These dietary cholesterol oxides profoundly influence the initiation of heart disease.Free radicals can also contribute to the formation of cholesterol oxides which are even more likely to damage the heart. Cholesterol oxides have been found in deep-fried foods, powdered eggs, processed meats and in human blood itself. Consequently, taking antioxidants like ascorbic acid is vital to protect against the cellular damage this type of free radical causes.112
In feeding experiments with animals, adding citric acid to a chitosan enriched diet resulted in a decreased feed consumption.77 The most likely explanation for this effect is that the citric acid may be enhancing the swelling action of chitosan leading to a sense of fullness, producing satiety and appetite suppression.
Indoles are remarkable phytochemicals which have the ability to selectively activate certain Mixed Function Oxidases (MFOs).113 These MFO’s help balance estrogen metabolism and prepare dietary toxins for elimination before they are absorbed. The presence of fiber in the intestines provides a bulk agent to carry the metabolized toxins out of the body. Chelat ed Minerals The very best approach to weight loss is to nutritionally augment food choices with nutrient supplementation. Certain biochemical compounds are essential to promoting vigor during the process of thermogenesis. Chelated minerals act to bolster, support and protect the organ systems of the body.114,115
For example, when fat is burned, heat and energy are released. If a lack of certain minerals exists, energy levels will drop. Minerals help to transport needed nutrients to depleted areas of the body, thereby stemming off the fatigue we so often experience after eating a fatty meal. Even more importantly, free radicals are released whenever fat is consumed and burned and the presence of chelated minerals helps to expedite the removal of these metabolites and facilitate the availability of fuel for energy.
Essential Fatty Acids
Prostaglandins control and balance many body functions. The dietary building blocks for making prostaglandins are the essential fatty acids (EFAs). The role of prostaglandins in weight loss has been extensively discussed in a recent review.116 EFAs exert profound lipid-lowering effects.They reduce the synthesis of triglycerides and very low density lipoproteins (bad cholesterol) in the liver. EFA supplementation coupled with a low-cholesterol, low-saturated fat in diet produces a complementary effect in lowering serum lipid levels.117 Garcinia Cambogia ( Hydroxy Cit ric Acid) Garcinia Cambogia contains hydroxycitric acid (HCA). This form of citric acid inhibits the liver’s ability to make fats out of carbohydrates.118
Carbohydrates are converted to glycogen stores, not fat stores, giving the body a better energy reserve and an increase in stamina.119 Ephedra And Thermogenisis Thermogenesis means “creating heat.” This is one of the ways our bodies have of burning off excess calories and maintaining a constant weight.120 This is an area of weight management research that is being intensely studied. When we repeatedly yo-yo diet or abuse ourselves by eating too much, our thermogenic ability may be reduced. Numerous animal and human studies have confirmed the benefits of ephedra and methylxanthines in inducing weight loss and restoring thermogenic responsiveness.43,44,121
Physical and Mental Stamina
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Many studies have been done to determine the effectiveness of ginseng in a variety of countries. Incomplete results have occurred in some instances. Long-term studies are most often recommended because ginsengs properties may not be seen in immediate experiments but are more effective when taken in small doses over a period of time. There have been enough credible studies done to now determine that high quality ginseng plants do contain active constituents known to be beneficial. Research has shown that the roots are effective against bronchitis and heart disease.16 Ginseng has been found to reduce blood cholesterol, build the immune system, improve brain function and memory, increase physical stamina, stimulate the function of the endocrine glands and strengthen disorders of the central nervous system.
Physical and Mental Stamina
A study down in the late 1950s and early 1960s by Brekhman and Dardymov in Russia involved an experiment with Soviet soldiers. They were studying the pharmacology and reactions of different varieties of East Asian ginseng. Some were given an extract of Asian ginseng and others a placebo before running a 3-kilometer race. Those given the ginseng ran faster with less fatigue than those given the placebo.17 Other tests performed by Brekhman involved gauging reading capacity after taking ginseng. It was noted that not only was the work and reading ability improved, but the effects continued for up to six weeks after the treatment.18
Another study giving radio operators either an Asian ginseng extract or placebo. The group given the ginseng performed better with fewer mistakes. The ginseng helped to increase stamina and mental function.19 A study involving rats followed the results when they were put in extremely cold water and forced to swim for a long period of time. The rats given the Asian ginseng were able to swim longer than the control group which indicated anti-fatigue activity. It is also important to note that ginseng increased the recovery rate of the exposed rats. The process was initiated in order to see if the point of exhaustion could be increased with the addition of ginseng. The results were favorable.20
Ginseng seems to be able to help slow glycogen utilization in the muscles when exercising. Fatigue accom-panying prolonged exercise is due in part to the depletion of glycogen and lactic acid build-up. Fatty acids are used as the energy source when there is enough oxygen available to reach the muscles reserving the glycogen stores to increase the body’s performance and reduce fatigue.21 Athletes may benefit from using ginseng to help improve and prolong their performance and abilities under stress during training and competition.
Serious athletes throughout the world use ginseng regularly. Some Olympic athletes take ginseng daily to increase and enhance their physical performance. Siberian ginseng has been found to help improve mental abilities in geriatric patients.22 This may be of benefit to all individuals as they age especially those prone to senility and Alzheimer’s patients. It is also thought to help an aging heart and brain tissue under stress and sustained work.23
Siberian ginseng has also been found to help increase energy and performance. Japanese medical researchers studied the extract of Eleuthero ginseng to determine anti-fatigue activity. The results showed increased physical performance and ability after taking the ginseng.24
Ginkgo: A Hair Tonic t hat Lowers Cholesterol Levels?
June 25, 2005 12:04 PM
Ginkgo: A Hair Tonic t hat Lowers Cholesterol Levels?
Japanese experiments have recently found that the ethanolic extract found in ginkgo leaves demonstrated the ability to stimulate hair re g rowth in mice which had been given a normal and a high butter diet. Test results found that ginkgo extract not only inhibited the increase of serum triglyceride levels in the mice who ate a highly saturated diet, it also significantly promoted the growth of hair in shaved areas.13 When ginkgo is combined with garlic, a considerable drop in cholesterol levels is also observed. A number of patients with elevated cholesterol levels showed an improvement rate of 35 percent versus a control group.14 The secret to keeping cholesterol leve l s consistently low is long-term therapy with garlic and ginkgo. When the extracts were no longer taken, cholesterol levels began to rise again.