Search Term: " Activated "
Omega-3 fatty acids can help reduce high insulin levels, and lowerthe risk of breast cancer in the process
May 15, 2019 02:34 PM
The elevated levels of insulin found in many people with obesity can elevate their risk of breast cancer, but new studies show that omega-3 free fatty acids can help mitigate this risk. Too much insulin can increase Akt and Erk1/2 phosphorylation, but omega-3s can help to reduce this effect. Likewise, omega-3 free fatty acids were able to cut down proliferation of MCF-7 cells. The research sheds some light onto why omega-3s appear to reduce the risk of breast cancer, although more research is needed.
"Researchers found a link between consumption of omega-3s and reduced breast cancer risk by lowering insulin levels. The study, which was published in Nutrition Research, tested the ability of omega-3 free fatty acids (FFAs) to reduce insulin-induced breast cancer cell proliferation."
Read more: https://www.naturalnews.com/2019-03-26-omega-3-can-reduce-high-insulin-levels-breast-cancer.html
Can aloe vera be used to treat sepsis?
May 10, 2019 10:42 AM
Aloe vera can be used for plenty of skin conditions, but new evidence suggests it could be used for blood infections, because of the metabolites in the plant. A Chinese and Japanese study looked at this using mice, and found that aloe metabolites suppressed inflammation, due to reduced nitric oxide level. This is important because sepsis harms the body's own tissues and organs, and can be fatal. Aloe also has other uses, such as skin care, warding off cancer, treating digestive issues, and lowering blood sugar levels.
"After using various tests to determine inflammation, the Chinese and Japanese research team found that aloe metabolites suppressed the expression of inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs). Aloe metabolites also decreased the production of proinflammatory cytokines and nitric oxide."
Read more: https://www.naturalnews.com/2019-04-17-can-aloe-vera-be-used-to-treat-sepsis.html
CBD may help smokers quit cigarettes, finds new study
June 20, 2018 04:44 PM
Humans have what is called a electrochemical system that can be directly impacted by substances referred to as endocannabinoids. One of these is cannabidiol (CBD). CBD oil was given to 30 participants in a 2013 study, and it showed that it helped them successfully reduce the amount of cigarettes that they smoked by 40%. More studies have to be done to determine a direct correlation, but this is good news for those who are continuously struggling to find natural ways to quit.
"In 2013, a study published in the journal Addictive Behaviors found that smokers who were given a CBD inhaler reduced their cigarette consumption by around 40% compared to those given a placebo."
Read more: https://www.healthnutnews.com/cbd-may-help-smokers-quit-cigarettes-finds-new-study/
6 Unexpected Health Benefits of Activated Charcoal
August 16, 2017 04:14 PM
While most are not aware of the health benefits found in activated charcoal, adherents of the ancient Indian medicinal system of Ayurveda understand the true value of this underrated ingredient. Activated charcoal is excellent at soothing the stomach, as it aids digestive health and can alleviate symptoms of bloating. Activated charcoal also provides benefits to the skin as well. Thanks to its powerful cleansing properties, it can clear up even the most stubborn of breakouts. Adherents of Ayurveda also swear by activated charcoal’s superior teeth whitening potential compared to that of traditional fluoride toothpaste. This versatile ingredient also helps to lower cholesterol, can cure a hangover, and act as a natural filter for your water.
"In other words, activated charcoal can help draw out toxins from your food, water, and body."
Read more: https://www.brit.co/unexpected-health-benefits-of-activated-charcoal/
Activated Charcoal for Intestinal Detox, Food Poisoning, and Hangovers
July 23, 2017 09:14 AM
A blog about alternative health treatments has published an article about the benefits of activated charcoal. This material adsorbs chemicals and has a great surface area. Thus, activated charcoal is good for treating poisoning. The article mentions how a professor drank poison and survived because he mixed charcoal into the drink. The article states this product can be used to treat digestive disorders. It can be applied to insect bites. It can even whiten teeth. A photo of activated charcoal is included.
"This makes the fine black powder incredibly valuable as an antidote for poisons, which readily adhere to the large surface area of the pores like paper clips to a magnet."
Read more: http://criticalhealthnews.com/health-news/25-ben-fuchs-articles/310-activated-charcoal-for-intestinal-detox-food-poisoning-and-hangovers
If you get less than 7 hours of sleep, this is what can happen to your belly fat
July 21, 2017 12:14 PM
When adult don’t get the recommended amount of sleep (7-8 hours), the body is out of balance, especially with a proper eating schedule. Sleep deprivation can lead to poor nutritional habits (i.e. eating convenience food at any hour of the day). This can lead to heart disease and diabetes. Getting enough sleep allows the body to reset and can help ward off many diseases. There are many techniques, such as hypnosis shown in the video, or limited screen time before bed, to relax and aide in the sleeping process.
"Even willpower may not be enough to overcome lack of sleep’s not-so-subtle influence on your appetite, as sleep restriction is associated with activation of your endocannabinoid system — the same one Activated by marijuana."
How To Use Activated Charcoal For Pink Eye
June 20, 2017 09:14 AM
There is a way to use activated charcoal for pink eye. Pink Eye impacts many people every year across the country. People might actually wonder if it is something to even worry about. One thing to remember is that Pink Eye is not a serious thing. People that get it do not have to seek emergency treatment and it will go away on its own. But, activated charcoal can get rid of it quickly and easily.
"Activated charcoal can be used to quickly and effectively treat pink eye, all without a visit to the doctor’s office."
Read more: http://www.thealternativedaily.com/how-to-use-activated-charcoal-for-pink-eye/
Tips On How To Use CBD Oil For Anxiety
May 23, 2017 06:44 PM
Many people feel that weed is only a plant that is for getting high. In any case, an ever increasing number of individuals are discovering that it is really a restorative plant that has a considerable measure of advantages. Nervousness is the point at which you feel this mind-boggling feeling of fear about ordinary exercises. Individuals have freeze assaults which is them being in battle or flight mode and they appear to occur for reasons unknown or in light of the fact that they were activated by a specific circumstance.
Read more: Tips On How To Use CBD Oil For Anxiety
Activated Charcoal Toothpaste and Other Natural Toothpaste Alternatives
May 19, 2017 08:44 AM
Many people look for natural product to clean their homes and even their bodies. One of these products is natural toothpaste. People have been using some of the options mentioned here for hundreds of years, long before toothpaste was being sold in stores. These are safe, natural and healthy options to keep your teeth clean, a very important part of hygiene which no one should overlook. Oral health helps you to stay healthier over all.
"If you struggle with gum inflammation, also known as gingivitis, try out turmeric toothpaste"
Read more: http://www.healthnutnews.com/activated-charcoal-toothpaste-natural-toothpaste-alternatives/
What Is Activated Charcoal Used For?
May 15, 2017 11:44 AM
Activated charcoal is generally used to remove harmful substances from a person's body, but it has several additional beneficial uses. One such use is to lighten and freshen the appearance of a person's teeth. Simply brush with it, being careful to clean it up as it can discolor sinks. It can also be mixed with clay to form a facial mask that unclogs pores. Charcoal will help to prevent gas when taken before a meal, and can lower a person's cholesterol. Lastly, it may mitigate the effects of exposure to mold.
"It’s generally used to treat and trap toxins and chemicals in the body"
Read more: http://www.thealternativedaily.com/what-is-activated-charcoal-used-for/
Have you tried Activated Charcoal? Should You Be Drinking Activated Charcoal to Cleanse? Yes, Charcoal!...
March 01, 2017 05:59 AM
Apparently there are more uses for charcoal than your summertime bbq. Research now shows that drinking charcoal in a gray juice form will help remove toxins from your body. It helps with symptoms from gas and bloating as well. Charcoal can also be used as a face mask to remove impurities from the skin. Stop by your local juice bar and try it. Let me know how it tastes.
"Activated charcoal adheres to digestive byproducts that can cause discomfort, which are then flushed out of your system."
What Are The Health Benefits Of Vitamin K2?
January 29, 2017 12:59 PM
Good for a multitude of health benefits, Vitamin K2 is often overlooked in favor of much more notable vitamins such as C or B12. It can help with everything from dental hygiene and health to improving upon our cardiovascular system. K2 is mainly found in animal products such as meat or eggs, as well as non-animal products such as fermented soybeans. Though it's not easy to detect a K2 deficiency, it can lead to severe complications in the long term.
"A nutritional dose of vitamin K can improve your cardiovascular health. It is beneficial for prevention of heart disease. According to the Rotterdam study in 2004, eating foods rich in natural vitamin K2 reduces the risk of both arterial calcification and cardiovascular disease by as much as 50%. Vitamin K2 prevent arterial calcification by stopping calcium from entering areas where it should not be."
A year-end look at superfoods: What's good, bad and just odd
January 09, 2017 07:59 AM
When it comes to nutrient dense foods in general there are some that stand out more than others. A lot of these foods are loaded with antioxidants, fiber, minerals, vitamins, and other nutrients in general. Some of these include chlorophyll, Activated charcoal, maple water, almond butter, banana flour, bowls, fermented dairy beverages, turmeric, and sparkling water.
"Chlorophyll is an excellent liver detoxifier that promotes energy, mental clarity, and weight loss."
Mother Nature’s Best Secret is Grape Seed Extract
December 25, 2014 08:08 PM
Benefits of Grape Seed
Grape seed extract is a powerful antioxidant, the benefits resemble a type of fountain of youth that invigorated individuals and improved cardiovascular health and improved weakened collagen levels. Research indicated that individuals who resided in France and consumed red wine enjoyed a longer lifespan due to consuming wine that possessed a high content of a type of flavonoid called proanthocyanidin.
High blood sugar damages the heart and hardens it resulting in heart attacks and heart disease. Researches uncovered a secret of grape seed extract; it Activated a blocker at the gene level stopping the body from heart hardening. Turning on this element at the cellular level deep inside of the mitochondrial DNA of a human being has assisted diabetic cardiomyopathy. French grape seed extract has an amazing impact on the body with blood sugar levels.
Germ managing elements have been identified inside of grape seed extract; it is a powerful anti-candida, reducing harmful bacteria keeping it in a healthy balance. People that are overweight who take the extract find that they reduce their calorie intake naturally. Persons who suffer with Alzheimer’s disease, if they are given the extract improve and maintain a higher mental function. This extract is excellent for all parts of your body, boosting the immune function at all levels.
Educative And Informative Details About NADH Supplement And Its Benefits
May 12, 2014 03:34 AM
What is a NADH
Nicotinamide Adenine Dinucleotide (NADH) is an Activated form of B vitamin niacinin, which is available naturally in the body, from poultry, meat, fish and in minimal quantities from vegetables and fruits. This substance is also commonly referred to as the most important coenzyme mainly because of the import role of transforming food-based energy into energy, which can be utilized by the body cells. Due to the roles played by NADH, it has been developed into supplements, which have various benefits. NADH role in the body is important since the body cannot utilize the energy inform of whole proteins, carbohydrates and fats which are the main sources of energy.
How NADH works
Instead, when the foods that provide the body with energy are ingested, they are usually broken down into smaller parts after being absorbed and distributed into various cells. One of the things that are derived after these foods being broken down is acetyl, which is a two-carbon molecule. Enzymes are the primary components that break the foods into acetyl. However, enzymes require coenzymes to break these foods properly and extract the energy from acetyl. This makes NADH is an important coenzyme, which extracts energy from reactions between oxygen and acetyl. This coenzyme also helps in transforming tyrosine, which is an amino acid into dopamine, which is a brain chemical.
Benefits of NADH
One of the primary benefits of NADH supplement is that the brain chemical it helps to produce known as dopamine helps in improving various brain functions. Some of these functions which this chemical affects include; concentration, mood, muscle movement, sexual drive and energy. It also helps in athletic performance, slowing aging process, Parkinson's disease, depression and Alzheimer's disease.
This supplement is also helpful on people with chronic fatigue syndrome. This is achieved through helping patients reduce anxiety and reduce heart rate. Consequently, the patient is able to relax and allow the body to function normally. Therefore, NADH supplement is helpful and has many benefits if it is used properly.
Beta Glucan can Boost your Immune System in a great way
November 18, 2013 07:43 AM
What is Beta Glucan
If you are one of those people that always remain ill or if your body cannot adopt easily with weather then it’s a sign of poor immunity and you need to improve the immunity system of your body. In order to do this you can take help of some medicines or you can consume some foods that naturally contain the Beta Glucan, which is a soluble fiber and it plays a key role in improvement of immunity system of your body.
Effects of Beta Glucan
If we talk about the effect of Beta Glucan on your immunity system it work on both the component of your immunity system that are acquired immune response and innate immune response system. In order to improve the immunity system f your body beta Glucan activate both of these component and as a result of this you get better immunity system.
How is Beta Glucan Works
In this process of immunity system improvement, First Beta Glucan combines itself with a specific type of white blood cell that is commonly known as Macrophage and as a result of this particular bonding, these white blood cells can detect and eliminate harmful foreign bodies in much better way. For this action of immunity system improvement innate immunity system is responsible.
Once your body gets the information about any kind external harmful bodies such as bacteria, virus or any other infection, acquired immune response system get Activated and this is the system that fights with all these external bodies. Beta Glucan improve this system as well so your body can communicate about these intruders and can defense the body in much better manner.
Other than improvement of immunity system of your body, Beta Glucan, can help you to fight variety of other problems as well including high cholesterol, diabetes, cancer and a lot of other diseases as well.
Interesting Facts About Activated Charcoal
November 03, 2013 12:19 AM
How Activated Charcoal is Made
Activated charcoal is very similar to normal charcoal which is made from coconut shell, wood, petroleum, peat or coal. To make Activated charcoal, the common charcoal is heated in the presence of some gases like argon, oxygen or nitrogen in a variety of processes, namely; physical or chemical activation. These processes open up millions of tiny pores between the present carbon atoms. These pores help the charcoal to easily trap select chemicals in a process known as adsorption. It is known by a myriad of names from Animal charcoal, Gas black to lamp black etc.
Uses of Activated Charcoal
The earliest documented usage of Activated charcoal was reported in the early 19th century in England where it was sold as charcoal biscuits. It was generally administered as an antidote to a wide variety of stomach problems and flatulence. It has since gained mainstream usage for a wide variety of ailments and can either be sold as an over the counter drug in certain countries as tablets or capsules or be prescribed by doctors in hospitals. It can also be used for pre-hospital purposes in emergency treatments.
One of the main uses of Activated charcoal has been in treating instances of overdoses and poisonings in the human body. It does this by adsorption (attaching to the poison by chemical attraction) thereby preventing its absorption in the gastrointestinal tract. It is also known to interrupt the enteroenteric circulation of some toxins and drugs thereby preventing poisoning. The correct dosage is usually 1 gram per kilogram of body mass and is usually given once to the patient even though in very acute instances it can be given to the patient more than once. Apart from the adsorption process, Activated charcoal can also be used to filter out any harmful drugs from affected person’s blood stream. It is worth noting though that for long term accumulation of toxins in the body through a variety of methods such as toxic herbicide infection, that the use of Activated charcoal to reverse the effects will not be successful.
What Are The Health Benefits Of L-Carnosine?
February 28, 2012 07:53 AM
Among the numerous natural compounds in the body, L-Carnosine is also one such beneficial compound that is naturally contained in the human body. Numerous health benefits are offered by this compound, and it plays an integral role in maintaining the wellness of an individual. However, as people begin growing old, are frequently stressed or have undergone some sort of a trauma, then the levels of this compound in the body are decreased.
What is L-Carnosine?
This compound is basically a dipeptide that comprises of alanine and histidine, which are two different types of amino acids. The brain, heart, kidneys, muscles, skin and the stomach are the organs where L-Carnosinecan be naturally found. Due to its potent antioxidant traits, this dipeptide is regarded as an effective anti-aging agent.
What Are The Health Benefits Of L-Carnosine?
As mentioned, Carnosine is an integral dipeptide in the body and quite an array of benefits are offered by it.
Due to the intense antioxidant qualities of L-Carnosine, the free radical damaged caused within the body is minimized. Free radicals are not good for the cells present in the body since they damage and kill cells, and can also alter DNA too. Thus, Alzheimer's disease, heart disease, cancer and skin damage, are some of the health problems people can suffer from as a result of altered DNA, damaged and dead cells due to free radicals. In comparison to vitamin E, this compound can protect cell membranes from oxidation more effectively because it is water-soluble.
Other Carnosine Benefits
The compound also helps in healing wounds as well. The connective tissues in the body are effectively repaired thanks to the antioxidant qualities of Carnosine, and the skin is ideally healed. The compound also helps reducing the risk of wound infection too.
Cataracts and other eye conditions can also be relieved with the help of the health benefits offered by this compound. Even though this compound is naturally contained in the eye, however, as people get older, its amount lessens. Thus, primary and mature senile cataracts can be effectively cured with eye drops containing L-Carnosine.
Even the heart is kept healthy by this compound as well. The heart tissue muscle is strengthened by this compound and enzymes that enable the heart muscles to contract are also Activated by it.
How to Increase the Level of L-Carnosine in the Body?
Those who want to increase the amount of this beneficial dipeptide in their body should eat a diet that essentially includes fish, meat and poultry. Dietary supplements can also supply the body with this compound. L-Carnosineis contained in certain multivitamin supplements, which contain various other amino acids, minerals, vitamins and other special nutrients. Thus, the overall positive effective of this compound in the body can be further enhanced by taking such supplements.
As long as the supplement being used contains nothing but natural ingredients, supplementing this compound in the body can help an individual avail many health benefits. L-Carnosine is, therefore, an important dipeptide and those who are growing old should consider supplementing it through diet or supplements.
What is Forskoline and How Does It Help You Loose Weight?
February 09, 2012 05:46 PM
While the Ayurvedic Coleus forskohlii contains numerous ingredients, however, the most integral active ingredient in the herb is known as Forskoline. It is the mint family that this herb belongs to, and Burma,India and Thailand, which are all subtropical areas, are some of the places where this herb grows. Over the years, a lot research has been done on the main ingredient in this herb. In the recent times, this ingredient has become particularly popular for the benefits that have been discovered it offers for weight loss.
What Can Forskoline Be Used For?
In the few clinical and scientific studies that were conducted on Forskoline, this natural component was discovered to be a lipolytic or a fat burning agent. The individuals who were subjected to testing lost quite a significant weight when they were give this ingredient to use as a weight loss aid. Ever since then, several weight loss products have been produced that contain this component as their main ingredient.
What is the Function of Forskoline?
The adenylate cyclase enzyme is Activated by this component. Typically, adenylate cyclase are also Activated by fat burning hormones, however, their have higher CNS effects. On the other hand, the CNS effects of Forskoline are different so no side effects are caused if it is used for losing weight. Thus, while functioning like most fat loss agents, the levels of the lipolytic hormone are not increased by it.
Apart from acting as a safe weight loss agent, Forskoline also offers various other health benefits too. It, in fact, particular helps with cardiovascular health. As far as cardiovascular health is concerned, not only this but several others of the active ingredients that the Coleus forskohlii have been discovered to be beneficial for the cardiovascular system.
What are the Side Effects of Forskoline?
There are actually no known side effects associated with the use of this component, which has been proven by the several studies conducted on it and the herb it comes from. Nonetheless, if people decide to use Forskoline, they should consult a doctor first. There are chances that people might experience drowsiness if they consume in a really large dose, which is natural considering it is an antihistamine, however, this should be avoided. Taking it before going to bed or taking it along with stimulate is most appropriate.
Today there are numerous Forskoline products available in the market and those who are looking for the best one should pay attention to the amount of this particular ingredient the product contains. Typically, a 2% extract in a 250 mg tablet is adequate enough. Products containing 10 to 20% of this extract can be considered the best. People should start using such a product with two to three doses of 25 to 60 mg in a day, divided accordingly.
These days it is hard to find weight loss products with so many benefits and almost no side effects. The weight loss products containing Forskoline might certainly seem like a miracle for those who want to lose weight and those who decide to use will indeed be able to effectively shed the pounds.
Your Diet May Be What's Causing Your Acne
September 19, 2011 06:05 PM
Although dieticians and physicians maintain that diet does not cause acne, this is not strictly true. Even dermatologists argue the point, but while it is generally agreed that eating fatty foods or excessive quantities of chocolate will not in itself lead to acne, there are certain valid arguments that diet has a role to play. Recent research has shed new light on dietary factors that can help to promote acne symptoms, if not being the sole cause of them.
Before discussing that, it is important to understand why acne gives rise to the symptoms that it does: lesions in the form of whiteheads and blackheads, pustules and cysts. While not necessary to discuss the biochemical details, the part that your diet has to play will not be understood without considering the effect of hormones on acne.
The reason that teenagers in particular appear to be more prone to acne is that an increased production of hormones has an effect on the condition that causes the symptoms of acne. Fundamentally, acne is characterized by the infection and inflammation of a mass of oil and dead skin cells within the pores of the skin, particularly on the face, neck, chest buttocks and back. If we discuss each of these elements first, and how they are created, then the relationship between diet and acne will become clear.
At a certain time in their lives, people experience a spurt of growth and develop sexually. This is initiated by the secretion of hormones, particularly of male sex hormones collectively known as androgens, and by various hormonal 'Growth Factors'. This stage of human development is known as puberty, although there is also an increase in androgen secretion by the adrenal glands just before menstruation and during pregnancy and menopause. Androgens such as testosterone are reserved not only for the male of the species!
An effect of androgens is to increase the rate of secretion of sebum from the sebaceous glands in the skin. The reason for this is unknown, though it has been hypothesized that its purpose is to waterproof the additional hair that is grown on the body at this time. Another suggested reason is as an olfactory warning to others to deter from sexual activity, in teenagers until their sexual development is complete, and in pre-menstrual, pregnant and menopausal women for obvious reasons. There is no substantial proof for any of these hypotheses, though the latter appears to make more sense than the former.
Irrespective of this, androgens also interfere with desquamation, and the dead skin cells within the pores tend to fall off irregularly and in clumps. This mix of dead skin cells and excess sebum clogs up the pores of the sebaceous follicles. Once this plug becomes infected with bacteria, the immune system is Activated, inflammation occurs, and leukocyte action leads to pus formation. That is what is known as acne.
In order to determine how diet and acne are connected, it would be necessary to determine what components of our diet can either stimulate sebum production, or stimulate androgen secretion. If no such link could be found, then it would be fair to descry any connection between acne and the food you eat. However, there is a connection, and it is a positive one.
In addition to their main function, insulin and a hormone known as IGF-1 (Insulin-like Growth Factor 1 that helps promote growth in children) promote the secretion of testosterone, a male hormone or androgen. Knowing, as we now do, that androgens promote the secretion of sebum, then anything that increases the levels of insulin or IGF-1 within the body will also lead to sebum production and hence to acne. What that infers is that any foodstuffs that increase the insulin levels in the blood can also lead to acne.
This inference is supported in many ways. For example, it has been found that while drinking milk promotes a greater risk of acne, eating yoghurt does not. Why is this? It is known that milk can increase insulin levels because of its high sugar content. The effect of bacterial activity to produce yoghurt reduces the amount of sugars in the milk it is made from because the bacteria live on the lactose. The same argument applies to cheese, which promotes lower insulin levels than milk, if not as low as yoghurt.
This being the case, then a diet low in sugars and carbohydrates should reduce the incidence of acne generally. Recent research has indicated that a diet high in refined carbohydrates and sugar increases both IGF-1 and insulin levels in the blood. This then creates a surge in male hormones which in turn leads to excessive sebum secretion and intermittent shedding of skin cells and so on to the growth of bacteria and acne. It is a logical progression, supported both by theory and by observation.
So how should a person with a propensity for acne change their diet? Switch to fruits, vegetables and grains. Non-fatty meats are also acceptable, and .lots of fish and other seafood. Studies have concluded that diets rich in seafood lead to very low acne rates. The Japanese and coastal Chinese suffer very little acne in comparison with those taking a Western diet, particularly an American diet.
One of the reasons for this is that omega-3 fatty acids help to reduce both inflammation and sebum production. The same is true of green tea that contains antioxidants that reduce the blood levels of dihydotetosterone and hence of sebum secretion by the sebaceous glands. We could go on, and list supplement after supplement that contain antioxidants and other substances that can reduce the production of sebum and hence of the symptoms of acne.
Vegetable oils, on the other hand, with their high omega-6 fatty acid content, can drive up sebum production and the activity of the immune system and the inflammatory response. There are few doubts left that, while acne is not specifically caused by what you eat, diet can contribute to it and that acne and its severity can be eased by eating a diet low in carbohydrates and other sugar-promoting foods.
How can I Tell if I am Magnesium Deficient?
February 09, 2011 01:25 PM
Magnesium The Essential Mineral
Magnesium is a dietary mineral that has established nutritional values in most countries. The presence of magnesium inside the human body involves many different chemical reactions, assisting more than 300 enzymes in their functional roles. That’s why we need to meet the daily recommended allowances for this dietary element, which has been calculated by the scientific community to supply the body with amounts adequate to support body functions.
An Essential Mineral
Not all enzymes are capable of producing the effects that they are programmed for on their own, and enzymes identified to rely on the presence of magnesium can be traced in almost all metabolic pathways. Molecules that comprise the structural units of RNA and DNA are extensively used as a source of energy of all cells, such as adenosine triphosphate or ATP. When enzymes utilize ATP for energy, they require another molecule that secures their binding to ATP, which is magnesium. In addition, ATP being the main source of energy that powers the functional roles of cells more often than not necessitates that it be bound to a magnesium ion to be fully Activated.
Magnesium is ubiquitous in nature, and green leafy vegetables are ideal sources of this dietary element as well as nuts, wheat, seafood, and meat. In spite of that, it has been reported that in the US alone more than 60 per cent of the population does not meet the recommended daily intake for magnesium. The availability of magnesium in our diet does not ensure absorption of this essential mineral, and a significant fraction is in fact excreted along with other waste products in the urine or feces. Interestingly, diet high in protein or fat actually interferes with the absorption of magnesium.
A general feeling of malaise must not be taken lightly, for it is key indicator of magnesium deficiency. Magnesium is indispensable at the cellular level, and insufficient amounts of this element will certainly affect the way you feel, bringing about the perception of fatigue. If you feel weak all the time for no known reason, then it is recommendable to visit your doctor and find out if you have an alarming case of magnesium deficiency.
Keep in mind that high concentrations of protein and fat in the foods that you eat contribute to malabsorption of magnesium, and subsequently malnutrition. Certain medical conditions are known to deplete your reserves of elemental magnesium present in your body, notably diabetes mellitus. Drugs and medications also washes away the magnesium found in your diet and your body especially osmotic diuretics, cisplatin, ciclosporin, amphetamines, and possibly proton pump inhibitors.
Continued exposure to stress and excessive intake of alcohol both result in the unhealthy drop of magnesium levels in the blood. While there are environmental settings that we may not be able to alter, we can certainly control what we ingest. Supplementation is the only surefire remedy for magnesium deficiency, but the best way to combat whatever symptoms you are experiencing is to seek medical advice.
It is Essential You Get Your Magnesium Daily!
Gymnema Sylvestre Leaf Extract
September 16, 2009 11:31 AM
Gymnema has been used for centuries throughout the world for medical purposes. Only recently has it gained popularity in the Western world. The herb grows naturally in Africa and India. It is traded all over the world. Generally, the leaves are the part used. However, the root seems to supply some medicinal properties as well. The plant is a vine-like woody plant that can be found growing on bushes and small tress. It is a member of the milkweed family.
Gymnema has been used by Ayurvedic physicians to treat ailments such as stomach problems, diabetes, and urinary disorders for more than two thousand years. Early physicians found that chewing some of the leaves helped an individual to lose a taste for sweets. Modern scientific research has confirmed that gymnemic acid, the active ingredient, blacks the taste of sugar and blocks sugar’s absorption by the body. It is also thought the gymnema suppresses the taste of saccharin and clycamate, which are two common artificial sweeteners. A study done in 1986 also suggests that this herb is able to significantly increase liver and pancreatic function. This ability is promising for diabetes, obesity, hypoglycemia, allergies, anemia, and osteoporosis.
This herb is used for blocking the passages that sugar is normally absorbed. This prevents calories from being absorbed and blood sugar levels are not so drastically affected. The herb is also thought to block the body’s desire for sweets. One study found a link between the taste buds and the absorption of sugar in the intestines. Because gymnemic acid, found in gymnema, has a molecular structure similar to sugar, these molecules can fill in the receptor locations on the taste buds temporarily, preventing the taste buds from being Activated by the sugar eaten. The same basic thing happens in intestines, as the structure of tissue in the intestines is similar to the taste-bud structure that detects sugar. The gymenmic acid fills in the receptors in the intestines, which prevents absorption.
One of the most promising uses of gymnema may be in cases of diabetes. Research on animals has found that a reduction of blood sugar levels occurs after the consumption of gymnema extract. The herb may help to reduce the amount of insulin needed by diabetic individuals on insulin therapy. The herb is found in combinations that are often associated with controlling blood glucose levels and metabolism. Gymnema seems to be successful in some cases of diabetes. Additionally, the herb has been found to actually improve both liver and pancreatic function.
Over time, this herb has proven to be a nontoxic remedy. Gymnema is used for many conditions. Among these are diabetes, digestion, urinary tract problems, obesity, hypoglycemia, allergies, anemia, cholesterol, and hyperactivity. Gymnema may be a useful remedy in the concern over sugar and sugar-related problems, along with many other medical ailments.
In short, the leaves and roots of the gymnema plant are used to provide antiperiodic, diuretic, and stomachic properties. Primarily, this herb is extremely beneficial in dealing with diabetes, hyperactivity, and hypoglycemia. Additionally, gymnema is very helpful in treating allergies, anemia, high cholesterol, gastric disorders, indigestion, obesity, and weight conditions. For more information on the many beneficial effects provided by gymnema, please feel free to contact a representative from your local health food store.
Strengthen The Liver and Kidneys With Leucine
April 27, 2009 02:08 PM
L-leucine is an amino acid that is used by the body to fuel exercise and muscle-building to provide you with that athletic edge that gets you ahead of your opponents. It does so in a number of ways, none of them specifically by the direct generation of energy as such.
It is also an essential amino acid, since it cannot be manufactured by your body and hence must be taken as a supplement or as part of your diet. Foods rich in leucine include nuts, whole wheat products such as wholemeal bread, and brown rice. It is a hydrophobic amino acid, meaning that it does not like water.
It is also one of three essential branched chain amino acids, the other two being L-valine and L-isoleucine, and offers many benefits to athletic performance that shall be discussed below It also helps to preserve the body's stores of glycogen, used as an emergency energy source. Other than these properties, it possesses others, such as the maintenance of the nitrogen balance in the body.
So how does it work to fuel your body while you are exercising? The answer is not as you might think. L-leucine doesn't increase your energy levels as creatine does when it elevates your ATP (adenosine triphosphate) levels. ATP is the molecule of energy that is synthesized in your body cells, and is then converted back to ADP, the diphosphate, with the release of energy in the form of muscular contractions.
This amino acid is what is referred to as a 'limiting' substance, in that the other amino acids cannot do their jobs in your body unless you have sufficient L-leucine in proportion to them. Specifically, you need two parts of L-valine and two parts of L-leucine to one part of L-isoleucine for optimum usage of the food that you eat.
Therefore you cannot just take the supplement without considering how much should be taken to ensure this balance. Excess will be wasted and a deficiency would fail to make proper use of the protein content of your food.
If you suffer from a deficiency, therefore, your body cannot make best use of the protein in your diet to the extent that muscle tissue will not be generated during exercise. In fact it causes catabolism, or the breakdown of muscle tissue, resulting in a loss of performance and possible increase in fatty tissue as opposed to lean muscle. The only way to build muscle is take in sufficient nitrogen in the form of amino acids and protein, along with L-leucine to put that protein to best use.
One of the major properties of L-leucine is in stimulating the synthesis of skeletal muscle tissue and by using a supplement, the protein balance can be positive after a workout. It has been shown that this protein balance is generally negative until specifically L-leucine is consumed.
The way it works is to activate a muscle-generating pathway known as mTOR (mammalian Target of Rapamycin). mTOR is normally Activated when the levels of ATP in the muscle cells is high, and when these levels drop then mTOR is deActivated. The activity of mTOR is sensitive to the concentration of L-leucine, and when the concentration of the amino acid in the body rises it informs mTOR that the protein in the diet is sufficient to manufacture skeletal muscle tissue, and so mTOR s Activated.
Exactly how this is done is unknown, but is a fact the mTOR depends upon both L-leucine concentration and also ATP levels. This amino acid also decreases catabolism through a number of different mechanisms, one of which involves increasing insulin levels.
In fact, when insulin and L-leucine levels increase at the same time, there is a synergy that promotes the synthesis of new protein. Not only that, but the response of insulin to the presence of carbohydrates is enhanced, this resulting in an enhancement of your body's metabolism.
The amino acid can also be used to help those suffering from kidney and liver problems because it increases liver protein synthesis. It is therefore a useful adjunct both to diabetics and those suffering from liver and kidney disease.
However, because L-leucine is an essential amino acid with so many important properties, a deficiency can have specific consequences. Catabolism has been stated earlier as one such reaction to a deficiency, and others include decreased energy levels and irregularities in the levels of blood sugar.
Everything about this substance is not good however, and when taken by itself in excess, it can reduce the amount of the other amino acids in the blood, particularly of the other two branched chain amino acids (BCAAs). This in turn upsets the balance of amino acids, and reduces further the ability of the body to produce muscle tissue until a balanced supplement is taken.
Leucine also helps to maintain the nitrogen balance. It is essential for the human body to maintain a positive nitrogen balance, and L-leucine supports this. In fact, one study has demonstrated that after 12 hours infusion with L-leucine, nitrogen balance was improved by as much as 23%.
A supplement alone is not always sufficient to maintain a positive nitrogen balance. It is generally essential that you rest your body for a sufficient length of time to allow protein to be generated. If you don't take the required amount of rest, a surplus of protein could be used to maintain energy levels rather than replace lost protein and maintain a good nitrogen balance.
A positive nitrogen balance is essential for the generation of muscle tissue, such as in bodybuilding for example, since all proteins contain nitrogen and the net nitrogen intake must exceed the excretion rate. Not in gaseous form, of course, but in the intake of amino acids and proteins. The more positive your nitrogen balance is, the faster you will recover after exercise. It is essential for anabolic exercise.
L-leucine, therefore, is a supplement that can help to maintain your current muscle mass while undergoing strenuous exercise, in addition to increasing it while resting. It offers other health benefits, one being helping to maintain clarity of thought in the aged. However, it is for its effect on muscular build-up and the athletic edge that provides that the supplement is most commonly taken.
Huperzine And Memory
December 04, 2008 01:20 PM
Chinese club moss goes by the name Huperzia serrata, and gives its name to the sesquiterpene alkaloid it contains: huperzine A. This alkaloid has been found to be a superstar in the arena of brain-saving treatments for conditions such as Alzheimer's and age-related senility. Studies in China have found up to 60% improvements in the cognitive functions of such patients, and its potential has been recorded in the Journal of the American Medical Association. This is no mere folk remedy, and is the subject of serious study.
Known as Qian Ceng Ta, Chinese club moss has been a part of traditional Chinese medicine for centuries for the treatment of fever and inflammation, which is not surprising considering that most plants contain antioxidants and anti-inflammatories. However, what is unusual is the fact that it has also been found effective in treating some forms of dementia and depression, and also helps to reduce the incidence of panic attacks in those susceptible to them.
Not only that, but the plant has been found to possess diuretic properties, and a reduction in the swelling associated with water retention could also help to reduce the pain and other effects of swelling and inflammation. However, for now it is its effect on the brain that we are concerned, and research has indicated the likely mechanism by which huperzine A works.
Huperzine is an enzyme inhibitor - specifically inhibiting the enzyme acetylcholinesterase that breaks down acetylcholine, a neurotransmitter involved in the processes of memory, learning and mood. Outside the brain, it is involved in the movement of skeletal muscle tissue as well as in the regulation of cardiac and other smooth muscles such as those of the blood vessels.
When acetylcholinesterase (AChE) attacks acetylcholine (ACh), the latter attaches to a chemical site on the enzyme where it is then destroyed. It is a deliberate function of the body, designed to terminate a synaptic transmission. The purpose of a neurotransmitter is to allow the transmission of an electrical impulse form one nerve cell to another over a gap between them known as a synapse. Once the transmission has been completed, the enzyme can destroy the neurotransmitter, and then another takes its place. In fact one molecule of AChE can destroy around 5,000 molecules of ACh.
However, with age and for other reasons, these neurotransmitters can become depleted so that it becomes increasingly more difficult for brain cells to communicate with each other, and their destruction becomes undesirable. There are drugs available to help prevent this happening (e.g. donepezil, galantamine and tacrine), and so help to improve the memory and mental function of people as they grow older or contract conditions such as Alzheimer's disease.
Huperzine A has been found to take up the site in the acetylcholinesterase molecule that would normally have been used by the acetylcholine, and so save it from destruction. The more Huperzine A molecules present, the more acetylcholine available to pass messages between brain cells, and the stronger the cognitive function of the subject or patient. The pharmaceutical drugs mentioned in the previous paragraph work in exactly the same way.
This is a very specific reaction, one molecule adopting exactly the same space as the other, and has been proved scientifically by comparing the physical shapes of the two molecules. It's just like a jigsaw puzzle, where only one piece can fit into each position. Except here there are two: Huperzine A and acetylcholine both fit into the exact same place in the chemical structure of the acetylcholinesterase molecule.
The biochemistry of the reactions involved is very complex, and shall not be discussed here, but the upshot is that Huperzine A can do exactly the same job as modern drugs to avoid this hydroxylation of the ACh needed for the proper functioning of your brain.
In fact, clinical trials have indicated Huperzine A not only to be comparable in effect to the drugs current used, but also likely safer with respect to the possible side effects. This has still to be confirmed, but the National Institute on Aging is currently carrying out a trial to evaluate this claim in tandem with its effect on Alzheimer's disease. It has also been examined at Harvard University for its effect on epilepsy on patients with whom alternative pharmaceutical treatments have been unsuccessful.
Another suggested benefit of Huperzine A is that it is an NMDA (N-methyl D-aspartate) receptor antagonist that provides protection against damage to the brain by an excess of glutamates, and that it can also help to protect nerve cells from damage. Since NDMA is responsible for the transmission of some types of pain, the antagonist can also act as an analgesic.
There are other benefits that Chinese club moss can provide, and myasthenia gravis is one of them. Although relatively rare, this is a serious condition in which acetylcholine receptors are deActivated on muscle cells. This is achieved through the autoimmune system malfunctioning and creating antibodies against the receptors, and the end result is paralysis and respiratory failure.
Huperzine A reduces the AChE available and so might possibly enable the acetylcholine to work more effectively and delay or even stop the deterioration of muscle function. When people hear of muscle paralysis they frequently forget that breathing requires muscle function, as indeed does your heartbeat. This is currently surmise, and studies are being carried out to determine whether or not this usage of Huperzine A is viable.
Another promising application of Chinese club moss extract is in preventing organophosphate poisoning. These pesticides permanently suppress acetylcholine. This results in seizures due to a lack of interruption of the signals from nerves to muscles. The seizures can result in rapid death from uncontrollable seizures, or from permanent contraction of the diaphragm muscle that allows breathing. Although no human studies have yet been carried out, animals given Huperzine A prior to organophosphate exposure have survived without seizures.
There are no doubts that Chinese club moss and the Huperzine A extracted from it are effective in preventing the suppression of acetylcholine, and in permitting the proper activity of this important neurotransmitter. It is finding an increasing number of potential uses beneficial to the human body, not the least of which would be a partial remedy for some of the effects of dementia and Alzheimer's disease.
October 02, 2008 09:36 AM
Cartilage has several roles to play in your body, an example of which is to form curved body parts that would otherwise be unsupported, such as the external contours of your ears or a large part of your nose. Without cartilage you ears and nose would flop around a lot, and it is also contained in the spine, to prevent your discs from grinding against each other.
However, the part that we are interested in is as a shock absorber between the bones of your joints. It allows bones to slide over one another without damage, either through friction or shock, and is also nature’s shock absorber, helping to support your weight while you are active. Thus, your cartilage protects from impact damage when you are running or jumping down from a height. This type of cartilage, known as articular cartilage, is bathed in a lubricating fluid known as synovial fluid, which introduces its own problems when your cartilage becomes damaged.
This damage can occur in several ways: as the result of a fall, for example, or direct contact with the joint when playing a physical contact sport such as football or soccer. It can also become damaged through wear and tear over a period of time, such with long distance runners or soccer players (again), and is also associated with age. Many years of continual use, especially amongst those with active rather than sedentary occupations, eventually lead to wear and damage.
Problems with the joint structure itself, known as osteoarthritis, can also damage the cartilage, as can being overweight for a lengthy period. You can also experience cartilage damage if you are bedridden or other wise immobile for long periods, because the cartilage needs regular movement to function correctly. This is connected with the blood supply, which will be discussed shortly.
Cartilage is constructed of cells known as chondrocytes that generate a fibrous matrix known as collagen, a mixture of amino acids known as elastin that allows the cartilage to return to its original shape after deformation, and non-collagenous matrix tissue containing proteins, water and proteoglycans that contain sulfated glycosaminoglycan chains. That last mixture is often referred to as ‘ground substance.’
One of the problems with cartilage is its lack of a direct blood supply, and it relies on the compression and decompression of the articular cartilage, or on the flexing of elastic cartilage, to create a pumping action that drives blood to the chondrocytes. This is why inactivity can cause cartilage damage, due to a lack of blood supply, and why it is repaired more slowly than other body components.
Once an injury or wear and tear damages a joint, the body’s natural defense, the immune system, is Activated, and the major part of that involved in cartilage damage is the inflammatory response. The joint becomes inflamed, the quantity of synovial fluid is increased to provide more protection and swells the joint, and enzymes (hyaluronidase) are produced which, although part of the natural defense system, actually degrade the synovial fluid and the cartilage.
This increases the amount of inflammation and the process becomes self-perpetuating, leading to the condition known as degenerative joint disease (DJD) because the body is unable to produce enough glucosamine to generate the proteoglycan needed for repair.
This is where glucosamine sulfate enters the scene. Glucosamine is a precursor for glycosaminoglycans (GAG), which as mentioned as above are components of proteoglycans in the cartilage matrix ground tissue. It has been shown to stimulate the biosynthesis of proteoglycan, and analysis has shown its presence within articular cartilage after administering it orally to patients with cartilage disease. It therefore makes its way to the right place.
Glucosamine is administered in the form of glucosamine sulfate, the highly electrically charged sulfate groups believed to aid in the compression properties of cartilage. It is rapidly absorbed into the bloodstream, although only about a quarter of the oral dose is eventually available to the body, and high concentrations accumulate in the liver, kidneys and in articular cartilage where it is used in the biosynthesis of GAG.
When in solution, glucosamine sulfate separates into ions: sulfate and glucosamine. Glucosamine ions are involved in the synthesis of GAG, that then combine with proteins to form proteoglycans, a component of the non-collagenous matrix of the cartilage. Although glucosamine is the major active component, there is evidence that the sulfate group contributes the stability of the matrix of the connective tissue since the uptake of sulfate ions increases with the amount of glucosamine sulfate used.
Another consideration here is that sulfate is an important part of proteoglycans, and glucosamine sulfate promotes not only the synthesis of glycosaminoglycans, but also of proteoglycans in general. Glucosamine is also active in regenerating the lubricating properties of the synovial fluid, and in hindering the activity of hyaluronidase, the enzyme that breaks down the hyaluronic acid in the synovial fluid.
Some people find that glucosamine, taken either alone or in conjunction with chondroitin sulfate and/or methyl sulfonyl methane (MSM), is more effective than the non-steroidal anti-inflammatory drugs (NSAIDs) used to reduce inflammation (e.g. Aspirin and Ibuprofen) and without the side effects of these substances. MSM contains dietary sulfur, which is necessary for cell structure and healthy cell repair. Methyl sulfone methane is know to be beneficial for painful conditions such as arthritis, and also improves the blood circulation. It might also play a part in helping glucosamine sulfate get to the site of the cartilage damage.
Glucosamine is a large molecule, however, and finds it difficult to make its way to the area around the joint due to the lack of a direct blood supply. It is therefore taken in relatively large doses to ensure that sufficient amounts get to where it is needed. Many people insist that glucosamine sulfate is very effective in reducing, or even eliminating, their pain, and it is finding increasing popularity in the treatment of arthritis and other conditions involving cartilage damage.
Activated Charcoal - Highly absorbent material to combat poisoning
April 24, 2008 02:44 PM
Activated charcoal has been treated by heat to open up millions of small spaces between the carbon atoms and turn it literally into an atomic sponge that adsorbs both organic and organic impurities.
This heat treatment is carried out in the absence of oxygen, so the charcoal cannot burn. Instead, what oxygen it did contain is driven off leaving behind all of these interstitial gaps that multiply the effective surface area by factors of ten. Since it is the surface area of the charcoal that determines its potency, then the greater this is the better.
Activated charcoal has a massive surface area, and just ten grams has the same surface area as nine American football pitches or 77 tennis courts. Ten grams is just marginally more than a third of an ounce. The term adsorb has a different meaning to absorb, and while a real sponge absorbs water by mopping it up through capillary action and suction, activation carbon adsorbs substances through a form of chemical attraction. You get rid of water from the sponge by squeezing it, but that doesn’t work with Activated charcoal, since the substances are bound to it, not just physically constrained.
This huge surface area provides Activated charcoal with innumerable bonding sites, and when chemicals that are attracted to carbon pass by they are attached to the surface. They cannot get free again, as water in a sponge can, but are bound to the surface of the carbon. Because the digestive system has no effect on charcoal then whatever is bound to it passes naturally through the body.
It is most effective at binding other carbon-based materials, and other substances with the right electronic arrangement, but others will just pass straight through. Because it is a chemical process, once all of the empty bonding sites have been taken up, the charcoal loses its effectiveness and has to be replaced. It is possible to regenerate it, but hardly worthwhile for you to do so because of the small quantities you use.
Because of the way it works, Activated charcoal can help people to recover from some forms of food poisoning. It can adsorb gases in the intestine and help to relieve the pain of excessive gas in the gut. It has many additional uses that will be touched on later, but for now we will look at its effect on poisons because that is where Activated charcoal is of greatest benefit to us.
It does not adsorb and neutralize all poisons, but is very effective with those that it can be sued for. Professor Touery proved a point when he drank a lethal dose of strychnine in front of colleagues at the French Academy of Medicine in 1831 and came through unscathed. He had mixed the strychnine with Activated charcoal, and the fact that he lived after drinking a dose that would certainly have led to a very painful death within minutes testifies to the powerful effect of Activated charcoal as an potential antidote for poisoning.
Ever medicine cabinet should have an emergency supply of Activated carbon, especially those with young children in the household. However, this is not good news for the pharmaceutical companies who have reacted by refuting some of the claims made in its favor: they have claimed that it is not effective against arsenic. If that is so, then how did Michel Bertrand survive after swallowing 5 grams of arsenic trioxide – 150 times what is regarded as the lethal dose? He did this is 1813 after mixing it with Activated charcoal, just as Professor Touery was to do 18 years later with ten times the lethal dose of strychnine.
It is true, however, that it does not have this degree of activity with all poisons, and it has no effect on cyanide, alcohols, antifreeze (glycols) and lithium. It also has no effect on corrosive poisons such as the strong alkalis used in oven clearers, or hydrocarbons such as kerosene. The way it works is adsorb the poison and prevent it being released into the body. For that to happen, the poison must have an affinity for carbon, and its adsorption site, and not all substances possess that property. Those that do however are permanently bound and therefore safe.
For charcoal to be effective in neutralizing a poison, it must be swallowed within an hour of taking the poison, or the poison will be too far advanced ion the digestive process for the charcoal to do any good. Keep in mind, though, that it is not selective, and Activated charcoal can adsorb nutrients and other beneficial constituents of your body’s chemistry. It is important therefore that you take in only when necessary: you might need several doses if the poison was severe, but once it has done its job it is not meant to be used as a maintenance material to take ‘just in case’. Used like that, it can do harm.
If charcoal can adsorb poisons then it makes sense to believe that it can also adsorb some of the harmful agents that cause food poisoning. Not all food poisoning of course, but certainly those organisms that emit toxins that are attracted to carbon. And this is, in fact, the case. Food poisoning is caused by bacteria rather than viruses, and is not the presence of the bacteria that make you vomit and feel very ill.
As bacteria grow in your body they release toxins, or poisons, into your digestive system. These poisons are what make you ill. They can seriously affect the complete gastro-intestinal tract, causing vomiting, diarrhea, and inflammation and swelling of the small and large intestine. The latter can cause abdominal cramps and severe colic, and the severity of the symptoms depends very much upon the type of bacteria and the number of them in your body.
Many of these toxins are attracted to carbon since they are frequently organic based, and Activated charcoal can be used to adsorb them. Once adsorbed they lose their potency, and since carbon is not digested by the body, they are passed harmlessly through the colon and eliminated in the faeces. It can also be used to eliminate many other foreign bodies from your gut, including viruses and fungi and might possibly reduce the concentration of uric acid, which can bring relief to gout sufferers.
Activated charcoal has many uses, and is normally available in capsule form. It can be dangerous to take too much, particularly if you suffer from intestinal problems that cause constipation, because the charcoal itself can have that effect. However, there is no better emergency treatment for accidental poisoning in the home, although, since it is not suitable for all poisons, you must still regard poisoning as an emergency and contact the emergency services.
Activated charcoal, or Activated carbon as it is sometimes called, is also a good emergency treatment for vomiting and the other unpleasant effects of food poisoning. It deals with bacterial toxins in the same way as any other, though once again you must refer to your physician before or after using it – preferably the former.
The Prevention and Treatment or Prostate Cancer
April 10, 2008 01:36 PM
Last week I shared with you the controversy surrounding the use of PSA screening to determine the status of the prostate. There are many doctors who do not believe that using PSA is accurate enough to rely on for determining whether or not a high PSA indicates prostate cancer. Many men, who have a high PSA, after more detailed examination, did not have cancer and men with a low PSA did have cancer. Some physicians do not believe that the current methods of diagnosing prostate disorders are saving lives. Also, there is a group of physicians nationwide that strongly believe the best treatment is no treatment but rather a “watch and wait” approach. Prostate cancer usually is slow growing and more than 70% of men who develop it are over 65.
The older a man is, the more likely he is to die of some other condition before his prostate cancer becomes a real threat. To reiterate, the American Cancer Society states, “at this time watchful waiting is a reasonable option for some men with slow growing cancers because it is not known whether active treatment such as surgery, radiation therapy or hormone therapy prolongs survival”. So what action can be taken? While prostate enlargement (BPH) is not related to prostate cancer, it can elevate PSA scores and can cause symptoms in 50% of men by age 80 and nearly all will show signs of BPH by age 85.
If you have early symptoms of BPH such as frequency of urination, a burning feeling after urination and the caliber of stream that isn’t what it used to be, getting up several times through the night and low back pain, taking a good prostate support formula will be your best treatment and prevention. Most men will notice a remarkable improvement within a few weeks. A good prostate support formula will provide relief for 80-90% of all men from these annoying symptoms.
But what about prostate cancer?
The best cure for prostate cancer is prevention. I’ll give you a complete supplement program for prevention but first what about PSA testing? “I don’t believe in screening for something when it’s too late. By the time cancer develops a positive mammography or a true high PSA are likely too late, or if fortunate, that particular cancer will not be a problem. It makes far more sense to prevent the problem in the first place. And there is clear data, prevention is possible”. Dr. Robert J. Rowen, MD, Second Opinion, Soundview Communications. My recommendation, based on research of several scientific studies, includes various nutritional supplements and herbal extracts.
Following are several very important studies that all men should be aware of. In 1966 Dr. Larry Clark of the University of Arizona published startling data suggesting that prostate cancer could be reduced by as much as an amazing 60% by supplemental yeast derived selenium, 200 mcg per day. Selenium is a powerful antioxidant and participates in key and crucial detoxification and free radical scavenging enzymes (80-90% of all disease is caused by free radical damage and inflammation).
Selenium is one of a number of antioxidants to prevent this free radical damage; In 1999 a New Zealand study published in the British Journal of Cancer documented a 40% lower incident of prostate cancer in men with the highest levels of omega-3 fatty acids EPA and DHA in their blood. These findings have been confirmed in other omega-3 fatty acid studies. Conversely, another published report documents a high level of omega-6 to omega-3 fatty acids in invasive prostate tissue samples. Taken together with recent reports on high levels of omega-6 fatty acids (soy, sunflower, safflower, peanut, corn and most vegetable oils) linked to breast cancer, a common thread emerges. The American diet is overwhelmed with omega-6 oils.
Excessive use of omega-6 fatty acids are cancer causing and also cause inflammation. Trans fatty acids from hydrogenated oils seriously add to the problem. There are other nutrients that have shown to reduce prostate-cancer risk. Vitamin E and lycopene have also shown to prevent prostate cancer. Lycopene is commonly found in tomatoes, especially cooked tomatoes. If you like spaghetti sauce or salsa, this is a great way to fight prostate cancer. While vitamin E, selenium, lycopene and omega-3 fatty acids are all great prostate supporting nutrients, through research I found a much more powerful combination of food grade molecules that can prevent and treat cancer.
Extensive research in the last few years has revealed that regular consumption of certain fruits and vegetables can reduce the risk of prostate cancer. Fruits and vegetables having the highest degree of prostate cancer protection are the following: grapes (resveratrol), garlic, tomatoes, hot peppers, turmeric (curcumin), ginger, berries, milk thistle, cloves and fennel. These foods are protective because they are extremely active and excellent antioxidants. My favorite is turmeric (curcumin) because not only is it an antioxidant, it is also an anti-inflammatory agent. When it has this dual effect it is many times more potent than other types of food. In the United States there is 30 times more prostate cancers diagnosed than there are in India where turmeric is consumed liberally in most of the Indian dishes. Cancer does not begin shortly before it’s diagnosed.
The origin of cancer may be years or decades in the process before it is even diagnosed as such. It is a multi-step process that goes through various phases such as cellular damage and transformation and culminates in the acquisition of invasive potential angiogenic properties and establishment of metastatic lesions. This process, and probably rightly so for all cancers, can be Activated by any one of the various environmental carcinogens (cancer causing); all forms of tobacco products, industrial emissions, gasoline vapors, inflammatory agents, food coloring and preservatives, excessive UV rays, alcohol, hair dyes, cleaning products and drugs.
The multi-step process of these cancer causing compounds progress in three stages; tumor initiation, promotion and progression phases. A powerful antioxidant/anti-inflammatory can prevent most if not all of the damaging effects when taken on a daily basis. Several population based studies indicate that people in Southeast Asian countries have a much lower risk of acquiring colon, gastrointestinal, prostate, breast and other cancers when compared to their western counterparts. It is very likely that constituents of their diet such as garlic, ginger, turmeric, onion, tomatoes, cruciferous vegetables, chili’s and green tea play an important role in their ability to avoid these cancers.
These foods, or key active extracts from these foods, are known to block the NF-kB activation process. Also, several phytochemicals such as curcumin, resveratrol and green tea catechins have been shown to suppress AP-1. Several chemopreventative phytochemicals including curcumin, resveratrol and green tea have been recently shown to be powerful inhibitors of several growth factor receptors including EGFR. Curcumin also possesses the capacity to inhibit the activation of the EGF-Receptor indicating that it has the potential to break the autocrine loops that are established in several advanced cancers.
Studies also suggest that curcumin, resveratrol and green tea can actually be used as safe, non-toxic treatments in drug resistant cancers. These natural phytochemicals (food grade) can help fight certain cancers thereby requiring a smaller dose of drug chemotherapy. They also can protect the body from the damages of drug chemotherapy and radiation. “This mini review presents evidence that chemopreventative agents, curcumin, green tea and resveratrol, can be used not just to prevent cancer but also to treat cancer. Because of their pharmacological safety, most chemopreventative agents can be used in combination with drug chemotherapeutic agents to enhance the affect at lower doses and thus minimize chemotherapy- induced toxicity. Because cancer is primarily a disease of old age, less toxic therapy is a major priority. This review reveals that molecular targets of chemopreventative agents are similar to those currently being used for the treatment of cancer. Tumor cells use multiple cell survival pathways to prevail and thus agents that can suppress multiple pathways have great potential for the treatment of cancer”1,2. Curcumin, resveratrol and green tea were as effective in preventing and treating certain cancers based on lab and animal studies. There have been approximately 20 human positive studies but much more needs to be done.
From the research that I have done, I am convinced sufficiently enough to take many of these compounds as a preventative of cancer. These compounds are completely safe and non-toxic even in high doses. What does one have to lose? Why not take the positive preventative measure? –Compliments of Terry Naturally
Ref: 1. Role of chemopreventaive agents in cancer therapy. Comprehensive Cancer Center Our Lady of Mercy Medical Center, New York Medical College, Bronx New York
2. Cytokine Research Section, Department of Bioimmuno Therapy, University of Texas, M.D Anderson Cancer Center, Houston Texas
First, the Painful Inflammation
April 03, 2008 12:43 PM
Inflammation occurs because of the reaction of your immune system to what it perceives as being the presence in your tissues of dangerous foreign particles. Your immune system generally reacts to particles. Typical particles are bacteria and viruses, pollen, smoke, your own body cells that are not doing what they should, moulds and fungi, and various other things that can circulate in your blood.
There are several reasons for the immune system being Activated, some of them historical due to your body having an imprinted memory of previous bacteria and viruses that it has dealt with, and others the reaction to new invaders that it has never met before, and for which your immune system creates antibodies to destroy. Another is the recognition of abnormal body cells that have to be destroyed before they can proliferate, and yet another is when the immune system gets confused and itself damages your own tissues such as in rheumatoid arthritis.
Whatever the cause, inflammation is a common result of the immune system going to work, and can be extremely painful. It can cause damage to our own joints, vascular system and major organs, although treatment of the inflammation does not reduce the effectiveness of the immune response. You can safely treat the inflammation with anti-inflammatories and painkillers without the condition getting worse.
Common physical manifestations of inflammation are the swollen and painful joints of rheumatoid arthritis (osteoarthritis is not an immune response), the swelling in the airway of asthma, the spots and swellings of measles and chickenpox, the lesions of psoriasis and the swelling and pain of abrasions and cuts that have gone ‘septic’ or ‘poisoned’. The latter two are simply examples of the effect of phagocytes and leucocytes on bacterial infection – the white blood cells and their cohorts!
The reason that inflammation causes pain is that it affects nerve endings, and causes pressure against the damaged tissues that initiated the immune response. Although regular painkillers can control the pain of inflammation to an extent, they are generally not the ideal treatment. Herbal treatments are not necessarily always the ideal treatments either, but boswellia is one herb that has been proved to be effective in reducing the pain of inflammation.
How to Manage Migraines Naturally: Magnesium - Feverfew - Butterbur - Ginger
December 21, 2007 10:41 AM
Before you can understand how to manage migraines naturally, it is necessary to understand exactly what they are and how certain treatments could work. It is not generally known that the word ‘migraine’ means ‘half the head’ because it frequently hurts only on the right or the left of the head of sufferer. Some people with migraines do feel pain on both sides at once, although this is not generally the case.
A migraine occurs in stages which are Activated by fluctuations in the hormone content of the blood. The ‘aura’, when you see spots and flashing lights in front of your eyes, is the first stage of a migraine attack, and during this time the blood vessels in your neck and head are contracting. You could also find it difficult to concentrate and your fingers could feel cold. At this point they do not have the headache that starts when the blood vessels begin to dilate.
Rather than the contracted blood vessels slowly returning to normal, your hormones have an excessively strong reaction, and cause them to dilate rapidly and become much wider than they should be leading to a severe headache due to pressure on the nerves. Different hormones can be involves with each attack, and the range of effective natural treatments reflect this fact. During this period, your brain could swell slightly, your muscles can tense up and other things can happen to the chemical and hormonal balance of your body. That is why some herbal treatments work for some but not for others, and different people find different treatments effective for them. What works for you might not work for somebody else if their migraine has a different cause. Basically, though, migraines occur in two phases, one being associated with an excess of hormones and the other with a shortage.
It is not easy to live with a migraine since it can be completely debilitating. Some just have a severe headache, while others are affected for days at a time. The headache can become before and after the onset of the shimmering lights and other optical effects that are generated by the brain. It would certainly be useful if those prone to migraines had one or more of the possible natural remedies to hand since there is rarely time to seek to seek professional medical help once the migraine begins, and through the use of natural remedies a potentially bad attack could be nipped in the bud, and at least its effect on you reduced.
Magnesium is common in green leafy vegetables such as spinach and cabbage, whole grains, nuts and seeds. It is an essential mineral for human biochemistry, and is also needed with calcium for healthy bone development and maintenance.
Magnesium is a muscle relaxant, and relaxes the muscles of the blood vessels helping them to relax their dilatancy that cause the migraine pain. It is also useful to help the immune function, reduces blood pressure (by the same blood vessel relaxing mechanism) and also the rhythm of your heart. Magnesium therefore provides you with many health benefits, and though the western diet is not generally deficient in magnesium, some areas can be and a magnesium-containing supplement will not do you harm.
However, particularly high dose of magnesium can lead to nausea, diarrhea, low blood pressure and many other unpleasant side effects, so do not take more than the RDA (recommended daily allowance) in your supplement. Many studies have confirmed its effectiveness in reducing the symptoms of migraine, but not all studies have been successful. However, the condition is so debilitating to so many people, that it should be tried although not in excess. Make sure, however, that your doctor is informed since it could interfere with other medication you are taking for your migraine.
Riboflavin, vitamin B-2, is also believed to useful in reducing the duration and frequency of migraine attacks, working in much the same way as magnesium. It is known that there are many cases of people who suffer from vitamin B-2 deficiency also suffering from migraines, and a riboflavin supplement is also worth trying if you are a consistent victim of this condition.
Feverfew is the best known of the herbal remedies for migraine, and has been used for centuries in the treatment of fevers, headache, migraine and other painful conditions such as arthritis. The active ingredient is parthenolide, an anti-inflammatory that is also an anti-hyperalgesic, and that would explain its effect on reducing the pain. It also blocks lipolysaccharide-induced osteolysis by suppressing the activity of a eukaryotic transcription factor protein known as NF-kappaB that can cause a number of immune response problems, including inflammatory conditions such as arthritis, hence its use to relieve that condition.
Its effect on migraines could be explained by this activity in repressing the inflammatory response to certain stimuli that could be brought about by hormonal activity. Because it must be taken for a few weeks before the actual problem arises in order to be effective against it, feverfew is not effective to treat an existing attack, but to prevent future attacks. Double blind studies have proved its effectiveness in many tests, but not in all. However, if you take feverfew as a regular supplement in you diet, you might never have to try magnesium or vitamin B-2 supplements.
Some people swear by the leaves of feverfew, eating one per day which is easy way to take it. It is important, however, that you do so regularly, since it can take for up to 6 – 8 weeks for you to notice a reduction in your attacks. Don’t give up after 5 or 6 weeks, but continue, since the results will be well worth it. If you stop for a week or two you will have to start all over again. You might get a sore mouth and perhaps mouth ulcers to start with, but these will eventually go once your body is used to it.
You are probably best not to take if you are pregnant since it could cause you to abort. Otherwise, however, it has been shown to be effective in many severe cases. Feverfew is bitter, and can be used as a tea with other herbs, such as rosemary, lavender and sage. If you are taking warfarin, aspirin or other blood-thinning drugs, see your doctor first, and the same is true of NSAIDs (non-steroidal anti-inflammatory drugs). If you are taking these for arthritis, the feverfew itself might be more effective!
If you are taking feverfew as a supplement using commercially available dried leaf then the recommended dosage is around 125mg of the dried leaf. It should contain at least 0.2% of parthenolide (0.25mg/daily), although other studies have indicated that a total of 0.7 mg parthenolide a day should be taken (100mg at 0.7%). Parthenolide is unstable so don’t take it after its sell by or best by date.
Butterbur is also useful in the treatment of migraines. The active ingredient here is petasin, a sesquiterpene ester that also has anti-inflammatory properties, all though it works in a different manner to feverfew. Here, it inhibits the activities of leukotriene generation in neutrophils and eosinophils, which indicates that it also possesses anti-allergenic properties that could help asthmatics that also suffer from migraines. It does not prevent the release of histamine, but does appear to reduce smooth muscle spasm.
You should never take the raw herb, only the extract, because it contains alkaloids that can harm you. The butterbur extract, however, is a perfectly safe supplement and found effective by many people in the treatment of migraine.
If your migraine is at the front of the head, then you should try ginger. Unlike feverfew, ginger works on a migraine as it is occurring, and improvement can be achieved for a bad migraine within half an hour. In fact if, like many people, you can feel a migraine coming on, half a teaspoon of freshly ground ginger can stop the pain before it starts.
Many herbal treatments for migraine include a combination of some of the above remedies, and many people swear by them. However, migraine treatment is very personal, and you should use what works best for you. If you are also taking other medical treatments however, please make sure that you refer to your physician before using any others, and that includes herbal remedies or supplements.
Elderberry Can Boost The Immune System In The Winter
December 03, 2007 09:44 PM
The immune system is frequently overworked when the days get shorter and the temperature starts to drop, and elderberry can boost the immune system in winter for those that find themselves susceptible to all the colds, flu and other viral infections that seem to come out of the woodwork at that time.
Elderberry is the fruit of the elder tree that is native to Asia, Europe and North America. They are found just about anywhere due to their tolerance for a wide range of climates and soil types, and are frequently found by river banks. There are a number of different types of elder, in both small tree and shrub form, and it is those with the black and blue berries that are useful medicinally, not those with red berries. It is not only the berries that are used, but also the elder flowers. Elderflower wine has long been a favorite country wine, and the berries are used to make jam, pies and also drunk as juice.
Elder has been used for countless years for treating viral diseases such as influenza and colds, and it has also been found by some to be effective for the treatment of cold sores (herpes simplex). Its effect on flu is thought to be that it prevents the virus from entering and infecting the body cells, but more on this later. Historically, it has been used to promote the excretion of waste products through urination and sweating, which might be another reason why it is effective against colds and flu and some general respiratory problems.
The juice contains anthocyanins in the form of anthocyanidin-3-glycosides that appear to be very bioavailable to the body. The anthocyanins are more easily absorbed than those of blackcurrant juice, and are very strong antioxidants. The antioxidant effect is reinforced by the presence of large quantities of vitamin C. This difference in bioavailability has been proved though the administration of both blackcurrant and elderberry juice to volunteers, and testing the presence of the anthocyanins in the urine. This is a measure of their bioavailability, or how easily they are absorbed by the body, and the greater this bioavailability, then the more effective is their antioxidant effect.
Separate studies have indicated that anthocyanins derived from berries in general, not just elderberry, can reduce oxidative stress due to age, and also to help brain function. An improvement in the memory of the elderly has been seen to have improved after a course of berry juices rich in these powerful antioxidants. Elderberry antioxidants also improve the stability of LDL cholesterol by protecting against free radical oxidation, and thus helping to reduce the incidence of atherosclerosis that is promoted by the deposition of the oxidized LDL cholesterol on artery walls. This in turn helps to reduce the possibility of cardiovascular disease.
However, it is its effect on the immune system for which elderberry is generally studied by the medical professions. Elderberry helps to boost the immune system predominantly through the production of cytokines. To explain how these work, a quick summary of how part of the immune system works will first be necessary.
When intrusion into the body by an antigen (foreign body) is detected, the initial response is the inflammatory response. Chemical messengers called cytokines are released into the blood to inform the other parts of the immune system that an invader has been spotted.
The immediate effect is to increase the flow of blood to the affected part of the body by dilation of the blood vessels. The spaces between the cells in the vessel walls increase to allow the larger components of the immune system, such as the phagocytes that consume and destroy bacteria. Proteins also congregate and the temperature at the site rises to promote the reactions that the body uses to eject the invaders. The tissue therefore swells due to all the extra fluid and gets hot. The area becomes painful due to the accumulation of material aggravating the nerves, and if there is an infection, pus will eventually be formed from the dead neutrophils used to kill the bacteria or virus.
There are many different types of cytokine, including those that initiate the inflammatory response and others that stop the immune response once the invader has been killed off. Other cytokines, such as the interferons, stop viruses from multiplying, and others take part in the response only to specific types of antigen. Each cytokine has a specific message to pass to the relevant components of the immune system in order that the immune response is appropriate to the invasion concerned and does not overreact. Hence, a grain of pollen in the nose will elicit a lesser response than a varicella antigen that leads to those horrible chickenpox pustules.
In general terms, cytokines give the immune system a kick start once an antigen is spotted. The elderberry anthocyanins produce predominantly inflammatory cytokines, but also one anti-inflammatory cytokine, and so helping to boost the inflammatory response.
Some viruses use what are known as spike proteins that mimic the molecules of their host in order to gain access to cells by binding to the target cell receptors. However, these spikes are easily recognized by the immune system, and the elderberry anthocyanins are active in promoting this recognition. For that reason, viruses vigorously continue to change and mutate to overcome this, one manifestation of their success in achieving this being in the annual infections of influenza that have overcome last year’s antibodies by means of this mutation.
The influenza virus contains what are known as hemagglutinin spikes on its surface which, when deActivated, cannot break through your cell walls, enter the cell and replicate, thus leading to influenza. That is the mechanism by which the constituents of elderberries help to control influenza and reduce its effect on your body. If not deActivated, the spikes allow the virus to invade the cell and provoke the immune response that you know as the flu.
Many such winter ailments have a similar mechanism, which is why, apart from its general health benefits through its high antioxidant content, that elderberry can boost the immune system in winter.
Do you experience muscle pain and inflammation?
April 25, 2007 03:30 PM
Everyone experiences muscle pain and inflammation due to overuse and exertion. We’ve all had those softball games, weekend camping trips or chore-intensive days when our body lets us know we’ve overdone it.
So, what can you do about it? Well, fortunately, there is a proprietary formula with clinically studied ingredients that provides a natural solution: FlexAgility MAX.
FlexAgility MAX is designed to reduce pain and inflammation due to overuse. Its clinically studied ingredients have been shown to help balance the body’s own inflammatory response. Let’s take a look at FlexAgility MAX and answer a few questions you may have about it.
Q. What is inflammation? Why does it happen?
A. Inflammation is actually an essential part of your body’s natural healing process. When some form of physical stress affects the body, the immune system responds by supplying defensive compounds to the stressed site. This is what causes the fluid build-up, pain and redness we typically associate with inflammation. And until the situation is resolved those symptoms will stick around. So, why is that good? Because without these signals – pain and inflammation – we’d probably do even more damage. In a sense, pain and inflammation are very effective stop signs.
The problem is, if our bodies are continuously bombarded by factors that trigger inflammation, these defenders (and their symptoms) are always around. This can mean unnecessary pain and inflammation following overuse and exertion.
Q. What does FlexAgility MAX have to do with inflammation?
A. FlexAgility MAX provides triple-action activity against occasional pain and inflammation, with powerful antioxidant free-radical scavengers, the enzyme bromelain, and a natural COX-2 inhibitor.
Q. So what is COX-2 and why should I inhibit it?
A. We’ve all been hearing a lot in the news about COX-2 inhibition and may have wondered about its connection to pain and inflammation. Let’s take a look:
Cyclooxygenase is an enzyme that comes in two main types, abbreviated for convenience: COX-1 and COX-2. The COX enzymes regulate compounds involved with inflammation, including prostaglandins. COX-1 is found throughout the body, and maintains the integrity of the stomach lining, circulation and kidneys.
COX-2 on the other hand, cruises along the central nervous system – it’s much more attuned to our brain’s sense of “what hurts.” Primarily Activated by inflammatory stress, COX-2 generates prostaglandins – the hormone-like defensive compounds that cause the responses we associate with pain and inflammation due to overuse.
You can understand why so much research has focused on COX-2 inhibition. Decreasing its activity means short-circuiting the “inflammation cascade” that follows occasional overuse.
Because COX-1 is associated with a healthy stomach lining, it is not an enzyme you want to inhibit. Unfortunately, many products don’t know the difference between COX-1 and COX-2 – filing both with one blast.
Fortunately, there are ingredients in FlexAgility MAX that can tell them apart. One of them is IsoOxygene.
IsoOxygene is a patented hops extract shown in scientific studies to significantly inhibit COX-2, while leaving COX-1 alone. And, it is a 20 times more potent COX-2 inhibitor than other tested popular botanic products, including curcumin and grape seed.
Q. How do antioxidants support the body during times of inflammation due to overuse?
A. Overall, the body ahs a pretty darn good repair system. However, oxidative stress due to free radical damage can take its toll, especially during times of occasional physical stress. Free radicals and reactive oxygen species can damage cells, because they are hungry, unstable molecules in search of electrons. To find them, they attack other cells. These pillaged cells then become free radicals themselves, setting off a chain reaction of oxidative stress.
Free radicals are formed during the body’s normal functions, and can have benefits, such as neutralizing viruses and bacteria. However, in doing do, they erode the body’s own antioxidant defenses, too. And, free radicals typically become very active during times of inflammation due to overuse or other stressors.
The good news is that the herbal and antioxidant elements in FlexAgility MAX help support the body’s own natural anti-inflammatory defenses.
Take vitamin C, for instance. This extremely well-known antioxidant has been scientifically studied for its beneficial effects on muscle, collagen and connective tissue health. Collagen and connective tissue is what helps hold us together – literally.
And famous antioxidant, green tea, has been well-studied for the benefits of a polyphenol called epigallocatechin-3-gallate, or simply EGCG. In scientific and clinical studies, EGCG from green tea works as an overall antioxidant, scavenging free radicals, and supporting healthy collagen. In fact, one study showed that green tea polyphenols supported collagen health by 50% versus only 16% in controls.
The green tea extract in FlexAgility MAX is especially focused on these beneficial polyphenols. It’s standardized to contain 70% polyphenols – half from EGCG. The green tea acts in concert with elderberry and ginger in the formula to help prevent oxidative stress to the body due to occasional overuse.
Anthocyanins are natural antioxidants found in berries and vegetables. Black elderberry extract, one of the herbal ingredients in FlexAgility MAX, was shown in scientific studies to be more bioavailable – that is, more readily used by the body – than the natural bioflavonoids of other plants. Again, antioxidants help keep the body in optimum health- especially during times of physical stress.
Ginger, used for centuries in Ayurvedic medicine, provides strong, natural antioxidant activity. In fact, a recent scientific study found more than 50 separate antioxidants in ginger root.
Of course, there are many components of plants that show strong antioxidant properties. A scientific study comparing flavonoid antioxidant activity and inflammation have shown that rutin was the most effective in reducing the inflammation cascade.
Boswellia serrata is a tree found growing in the dry, hilly regions of
Another antioxidant ingredient in FlexAgility MAX, N-acetylcysteine (NAC), even helps the body produce more of its own antioxidants, cysteine and glutathione. In a double-blind, placebo-controlled clinical study, N-acetylcysteine inhibited occasional pain and inflammation due to overuse and attenuated fatigue by 26% compared to controls!
N-acetylcysteine has also been shown in scientific tests to act as an antioxidant, supporting healthy collagen and synovial fluid.
The last ingredient, bromelain, provides the enzymatic pathway used by FlexAgility MAX. Bromelain is a proteolytic enzyme derived from pineapple. Clinical and scientific studies showed benefits from bromelain in reducing pain and inflammation from occasional overuse.
So, there you have it- the triple action of FlexAgility MAX: COX-2 inhibition (and COX-1 sparing), antioxidant benefits, and enzyme support.
Q. Is there another product you’d recommend that I use with FlexAgility MAX?
A. One other product I recommend without hesitation is GS-500, a glucosamine sulfate supplement that has been shown to help build and support cartilage. The body’s connective tissue and cartilage include a natural compound called glucosamine. Supplemental glucosamine sulfate is up to 98% absorbable, so more glucosamine reaches the target structures. It has been clinically studied on its effect in building cartilage.
About Enzymatic Therapy:
Like Chris, Enzymatic Therapy is a trailblazer. Since our founding in 1981, we’ve been leading the industry with innovative natural products. After all, in 1993, Enzymatic Therapy introduced glucosamine sulfate, shown to help build and support cartilage, to the
In the intervening years, Enzymatic Therapy has been at the frontline of innovation and invention. Many revolutionary precuts, including Saventaro, Cell Forte, Heartburn Free, Petadolex Patented Brain Support, Whole Body Cleanse, Earth’s Promise, Hot Plants for Him and Hot Plants for Her have been introduced by Enzymatic Therapy.
One of the newest products, (and the reason you’re reading this) is FlexAgility MAX. FlexAgility MAX works with the body’s own natural anti-inflammatory pathways to relieve pain and reduce inflammation due to occasional overuse. Our proprietary FlexBend of ingredients, combined with antioxidants and the proteolytic enzyme, bromelain, is unique among natural products.
Complete Liver Cleanse
April 19, 2007 04:17 PM
Complete Liver Cleanse
Technical Data Sheet
The liver performs over 500 functions, including metabolizing carbohydrates and proteins, synthesizing and storing vitamins, and regulating hormones – naming just a few. To do this job, the liver is also required to be exposed to potentially harmful toxins and chemicals, every day.
One way to support the liver is through periodic supplementation with the proper balance of herbal ingredients, phytosterols, and fiber. Complete Liver Cleanse is a convenient, multi-ingredient formula that supports overall liver health and detoxification.
Complete Liver Cleanse:
Includes ingredients for various aspects of liver and gallbladder support:
-Herbal ingredients that support liver and gallbladder health
-Detoxifying ingredients that keep bound toxins from being reabsorbed
-Phytosterols to block cholesterol absorption in the intestines
-Fiber that moves cholesterol and toxins out of the body
-Oat beta-glucan fiber with up to 4 times higher viscosity than other beta-glucan
-Simple, two week liver cleanse program
Each 3 capsules contain:
Calcium (as calcium D-glucarate) 13 mg
Proprietary PuraFiber Blend: 1 mg
Viscofiber Oat B-Gucan Concentrate, phytosterols
(beta sitosterol, campesterol, stigmasterol, brassicasterol,
and other plant sterols), and glucomannan
Milk Thistle (Silybum marianum) Fruit Phytosome 220 mg
One part Milk Thistle Extract, standardized to contain 80%
Silymarin bound to two parts phosphatidylcholine (soy) using
a patented process
Burdock (Arctium lappa) Root Extract 4:1 100 mg
Calcium D-Glucarate 100 mg
Boldo (Peumus boldus) Leaf Extract 2:1 75 mg
Turmeric (Curcuma longa) Rhizome Extract 50 mg
Standardized to contain 90% curcuminoids
Dandelion (Taraxacum offinale) Root Extract 4:1 50 mg
Artichoke (Cynara scolymus) Leaf Extract 30 mg
Standardized to contain 13-18% caffeylquinic
Acids calculated as chlorogenic acid
Contains no: sugar, salt, yeast, wheat, dairy products, artificial coloring, artificial flavoring, ingredients of animal origin, or preservatives. This product contains natural ingredients; color variations are normal.
Other ingredients: See label for most current information
Viscofiber is a registered trademark of Cebena Bioproducts, Inc. The use and composition of the Viscofiber proprietary formula is protected by patients and patent applications filed in the
This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, LLC, and protected by
HOW DOES IT WORK?
Every day, the liver must process an almost unbelievable amount of blood – at a rate of three pints every minute. All the while, the liver performs over 500 physiologic functions, including protein and glucose synthesis, carbohydrate metabolism, vitamin and mineral storage, synthesis of clotting factors, urea formation, metabolism of medications, and the production of bile. The liver also assists in hormonal regulation, blood glucose control, and other regulatory functions.
Harmful substances that have been neutralized by the liver are carried to the intestines and kidneys for excretion. They are transported by bile, a greenish, watery solution that is synthesized, and continuously being excreted, by the liver. Stored in the gallbladder, a small sac cupped in the under surface of the liver, bile is also required for the digestion of dietary fats. However, in the case of toxins, bile is primarily an early transporter of the toxic compounds to the intestines, where they can be bound to fiber that helps transport them out of the body. Environmental toxins, including lipid (fat) soluble toxins, are broken into water-soluble components by bile to be excreted through the kidneys or colon.
Detoxification refers to the process of excreting potentially harmful compounds that are both generated by the body and acquired through exposure to the environment. In the body, toxins are generated as by-products of cellular metabolic processes. Examples include dead and digested bacteria, hydrogen peroxide, cellular debris, and carbon dioxide.
The Environmental Protection Agency has determined that the amount of environmental toxins in the air, groundwater, and soil has increased significantly in the last 40 years. In fact, the use of pesticides has doubled every ten years since 1945. Americans are increasingly exposed to heavy metals, pesticides, fossil fuel emissions, sulfur oxides, hydrocarbons, and other harmful chemicals. The Environmental Protection Agency reports that traces of toxic chemicals can now be found in nearly every American.
Herbal Liver Support
One of the major components in Complete Liver Cleanse is its milk thistle extract, standardized to contain 80% silymarin, the plant’s most bioactive compound. Milk Thistle provides support, at a cellular level, for healthy liver function. A patented delivery system, known as the Phytosome process, provides superior absorption of the milk thistle extract.
Silymarin, a key compound found in milk thistle, is a mixture of flavonoids with a long history of liver support. Silymarin supports the health of Kupffer cells, specialized liver cells responsible for removing bacteria, old blood cells, and other foreign matter from the liver’s blood supply. Silymarin scavenges free radicals (superoxide anion radical and nitric oxide) produced by Activated Kupffer cells, supports healthy leukotriene levels, and supports glutathione production that is used in detoxification.
Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic functions. Studies of silymarin have demonstrated that it supports the health of the hepatocyte outer membrane, which is crucial to the liver’s detoxification processes. Silymarin also supports the healthy regenerative ability of the liver through support of protein synthesis in the hepatocytes.
A special, patented proves known as Phytosome enhances the absorption of milk thistle in Complete Liver Cleanse. The Phytosome process pairs herbal ingredients with phosphatidylcholine molecules. Phosphatidylcholine is a naturally occurring substance found in soybeans, egg yolks, and some vegetables. In the body, phosphatidylcholine is an important building block of cell membranes.
When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine molecule facilitates absorption through the intestines into the bloodstream. Research has shown increased blood and serum levels for phytosome herbs in comparison to the individual herb alone.
To test whether binding an herb with phosphatidylcholine increased its bioavailability, researchers gave volunteers identical amounts of either milk thistle alone, or milk thistle phytosome. The researchers then took blood sample from the participants and measured the level of silybin (a key compound in milk thistle). The measurements showed that silybin levels in participants taking the phytosome form of milk thistle were higher, and that silybin was detected for a longer time, than those who took milk thistle without the phytosome delivery system.
Other Herbal Liver Supportive Ingredients
Herbal extracts are often at their best when they are working synergistically – that is, when different constituents of each plant work together and support each other. Complete Liver Cleanse contains a variety of herbal extracts that have noted benefits for supporting the body’s healthy bile flow and free-radical scavenging effects. These ingredients provide a wide spectrum of liver supportive benefits.
For instance, dandelion root extract supports healthy bile flow from the gallbladder.
Burdock is originally native to Europe and Asia, but was introduced to
Burdock root (Arctium lappa) supports the natural physiologic processes of organs involved in detoxification and elimination: notably, the liver, kidneys, and intestines.
Bolodo (pemus boldus) is a small evergreen native to South America, but naturalized to southern
In scientific studies, boldo appears to have strong free-radical scavenging ability, mostly attributed to the catechin and flavonoids content of its leaves. In a clinical study, boldo also appears to relax smooth muscle and support intestinal transit time.
Artichoke Leaf extract specifically supports healthy bile production in the liver and healthy gastrointestinal function in general. Research into artichoke’s gastrointestinal supportive properties has included at least three clinical trials. Artichoke’s role in supporting healthy cholesterol levels within normal limits has also been investigated.
Turmeric (Curcuma longa) is a perennial shrub native to southern
More recently, turmeric has been investigated for its support of healthy bile secretion, and pancreatic and gastric function.
In a scientific study, dietary curcuminoids derived from turmeric supported healthy lipid metabolism and cholesterol levels already within normal limits.
Curcumin has also been shown in scientific studies to enhance the activity of glutathione S-transferase - an enzyme responsible for linking glutathione (one of the body’s natural antioxidants) with toxins to help remove them from the body. In this way, it provides additional support for healthy liver function.
The process of detoxification is the breakdown and excretion of substances that are no longer needed or may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding them to glucuronic acid in the liver, and then excreting this compound in the bile.
However, this process can be disrupted by B-glucuronidase, an enzyme that is produced by intestinal bacteria. This enzyme has the ability to break (uncouple) the chemical bond established by glucuronic acid. This action releases the bound toxins, which are then reabsorbed into the body instead of being excreted.
Calcium D-Glucarate is the calcium salt of d-glucaric acid. It is found in both the human body, and in some plant sources, including broccoli and oranges.
Calcium d0glucarate enhances the body’s detoxification systems by inhibiting the actions of beta-glucuronidase. This helps decrease the portion of active compounds that could be hazardous to the body.
Cholesterol is a waxy, fat-like substance that is vital to fat digestion, cell structure, nerve insulation and hormone production. Cholesterol comes from two sources: dietary or “exogenous” cholesterol absorbed in the intestine, and “endogenous” cholesterol formed mostly by the liver and stored in the gallbladder.
Cholesterol occurs in two forms known as lipoproteins. Lipoproteins act as transports that carry fat s to and from the cells.
High-density lipoprotein (HDL) carries low lipid density cholesterol (LDL) away from arterial walls and returns it to the bloodstream. LDL then travels back to the liver, which processes and eliminates it. While high levels of HDL cholesterol is desirable, high amounts of LDL cholesterol is not supportive of optimal health.
LDL-cholesterol is both synthesized in the body, or absorbed into the bloodstream through receptor sites in the intestines. Think of these receptors as “parking spaces” for cholesterol. As it happens, the liver can receive up to 500 mg per day of cholesterol from intestinal absorption. (It can also produce as much as 1000 mg per day).
One way to help reduce the absorption of LDL cholesterol molecules it to occupy their “parking places” in the intestines. Phytosterols in Liver Cleanse are essentially the “fat” of plants. They’re found in nuts, corn and rice and are some of the “good” fats associated with the benefits of olive oil, flaxseed oil and other healthy oils.
The structure of phytosterols is so similar to cholesterol that they fit perfectly in the specially-shaped intestinal parking spaces that LDL-cholesterol would normally occupy.
Taken with, or just before meals, phytosterols block the cholesterol receptor sites so that cholesterol is excreted from the body rather than absorbed. Phytosterols also have the additional role of helping promote healthy bile salt excretion in the intestines.
The phytosterol blend in Complete Liver Cleanse can help minimize the absorption of cholesterol from high-protein food sources, help retain healthy cholesterol levels that are within normal limits, and move bile sat through the digestive system.
Fiber and detoxification
Fiber plays a key role in the removal and excretion of intestinal toxins in detoxification. Only fibers that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when combining different fiber types. Complete Liver Cleanse contains a combination of oat beta-glucan and konjac fiber that has been shown in scientific studies to bind to bile salts.
Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are resistant to digestive fluids or enzymes – that is, they aren’t absorbed into the bloodstream. So, while fiber itself doesn’t necessarily provide nutrients, it does promote laxation and modulate gastric and intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the formation of short chain fatty acids, or SCFA.
SCFA have a simple, but important job: to be absorbed by the colon mucosa, increasing fecal matter bulk and providing energy. Fiber has been demonstrated in numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and endocrine function health.
Complete Liver Cleanse also features two unique fibers to promote detoxification – konjac and oat beta-glucan.
Konjac, (Amorphophallus Konjac) is a tuber native to
As a fiber, konjac has shown positive results maintaining healthy cholesterol levels within normal limits in clinical studies. This beneficial effect is due to konjac’s ability to boost excretion of bile acid.
Oat beta-glucan has been a widely studied fiber source for supporting healthy cholesterol levels within normal limits.
In a randomized clinical study, oat beta-glucan showed support of healthy HDL/LDL ratios already within normal limits in individuals over a three week trial.
Closely linked to cholesterol, oat beta-glucan has also been studied for its support of healthy bile excretion.
Fiber has benefits beyond maintaining healthy cholesterol levels already within normal limits. It also contributes to healthy blood sugar levels already within normal limits. In a double-blind, clinical study, the oat beta-glucan fiber used in Liver Cleanse was shown to have 4 times higher viscosity than another high concentrate beta-glucan fiber.
Viscosity – the resistance to flow – is an important factor in beta-glucan, and all fiber. Water, for instance, would have a low viscosity, because it provides very little resistance to movement. Fiber, on the other hand, should have a higher viscosity in order to maximize its transit time through the GI tract, providing a gentle “scrubbing” on the intestinal walls. Therefore, the higher the viscosity, the greater the potential benefit.
Three capsules in the morning and three capsules at bedtime for 14 days.
Warnings: Do not use if you know or suspect you have an obstructed bile duct or problematic gallstones. If pregnant, nursing or taking prescription drugs, consult your healthcare practitioner prior to use. Keep out of reach of children.
April 09, 2007 05:02 PM
EpiCor® is a unique and novel dietary supplement used for support of immune health, with a fascinating history of discovery. In 1943, a company in
Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product. This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness” of the employees at the fermentation plant. This investigation and subsequent research studies led to the formation of a new company called Embria Health Sciences, which now produces EpiCor® as a supplement for humans to support immune system health.1 Doctor’s Best® is proud to now offer the benefits of EpiCor® to its customers.
Beneficial Support of the Immune System and Activation of Natural Killer (NK) Cells in vitro*
A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age and gender matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group. These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor™ specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes. These results represent benefits on various cellular players of both the specific and innate parts of the immune system.1,3,4
NK cells are one of the first lines of defense used by the immune system. An in vitro study performed on human cells showed that NK cells were Activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker. The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree.1,2 B cell activation was also noted through increased expression of CD80 and CD86 markers.2 Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.2
High Metabolite Immunogen*: Nutrient Make-up
Production of EpiCor® utilizes the common and harmless bakers or brewers yeast Saccharomyces cerevisiae in a patented process called MetaGen4™, a multi-stage fermentation and drying process. It differs from other yeast products in that it contains both the yeast itself as well as the metabolites or “nutrilites” formed by the fermentation process, which are present in the media.1 Together the media containing the metabolites and the yeast are dried to form EpiCor®. Analysis of EpiCor® reveals that it contains a mixture of natural polyphenols, phytosterols, beta-glucans, mannan oligosaccharides, fiber, trace amounts of B vitamins and minerals, as well as a host of other nutritional compounds.1,2
Beneficial Antioxidant Activity*
EpiCor® was tested for antioxidant activity in an in vitro assay called the Oxygen Radical Absorbance Capacity assay (ORAC). In this assay, EpiCor® was shown to have a total ORAC antioxidant level of 610 micromol TE (tocopherol (vitamin E) equivalents) units (ORAC units) per gram dry weight, which soared above other high antioxidant level foods such as cranberries (93 ORAC units per gram dry weight) and blueberries (62 ORAC units per gram dry weight).1,3,5
In another study, freshly isolated human neutrophils were treated with EpiCor® followed by the free radical generator hydrogen peroxide. Cells were treated with a dye that fluoresces when attacked by free radicals. Those cells treated with EpiCor® showed decreased fluorescence intensity compared to control cells not treated with EpiCor®, verifying antioxidant activity in vitro.2
Numerous safety tests have been conducted on EpiCor®, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor®. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.1,3
In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor®. EpiCor® also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor® does not cause over-reactivity of cells1,3.
The effect of EpiCor® on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor® and compared to both positive and negative controls. EpiCor® did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.1
Lastly, EpiCor® was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found1.
EpiCor® also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists1.
EpiCor® is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.*
Suggested Adult Use: Take one capsule daily with or without food.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Embria Health Sciences
2. Hart et al. A new Saccharomyces cerevisiae based product has anti-inflammatory effects while specifically activating human NK and B lymphocyte subsets. Unpublished study, personal communication.
3. Schauss AG, Jensen G, Vojdani A, Financsek I. After decades of ingestion by farm animals, the discovery of a yeast fermentate with unexpected significant immune modulatory activity when consumed by humans. [abstract] Journal of the
4. Schauss AG, Vodjani A. Discovery of an edible fermentation product with unusual immune enhancing properties in humans. [abstract] FASEB J, 2006; 20(4):A143.
5. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the
The Power Plant of the Amazon
March 02, 2007 11:34 AM
It may surprise most Americans to know that rainforest plants are the original source for one-fourth of the chemotherapy medications used today. Plants offer a plethora of beneficial compounds, and rainforests contain a superabundance of beneficial plants.
In fact, plant medicines are the most widely used medicines of all types in the world. Over eighty-five percent of the world’s population uses plant and herbal medicines as their primary medicines. That’s 5.1 billion (5,100,000,000) people worldwide! While Americans overwhelmingly use synthetically manufactured pharmaceuticals to cure their ills, the vast majority of Earth’s inhabitants use healing plant medicines instead.
One of the most powerful healing rainforest plant medicines is cat’s claw, or Uncaria tomentosa. This high climbing woody vine grows at the base of tall trees in the Peruvian rainforest. The plant’s claw-shaped thorns latch onto the trees and spiral further upward, nourished by the lush rainforest environment. For over 2,000 years, the Ashaninka, a tribal people of the Peruvian rainforest, have used the root of U. tomentosa to treat illnesses in the tribe, including asthma, bladder infections, infected wounds, arthritis, bone pain, bowel inflammation, and cancer.
Q. I’ve heard about cat’s claw, but what does it do and how do I know which one is right for me?
Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today. One reason that it’s so confusing is there are so many kinds of cat’s claw supplements-there are cat’s claw leaves, cat’s claw bark, and even cat’s claw twigs. While each of these supplements claim to help the immune system, it is the root of Uncaria tomentosa that is proven to impart the true cat’s claw health benefits.
Scientists, who have extensively studied every part of the plant, discovered that extracts made from selected cat’s claw roots possess the healing power to treat and prevent diseases like cancer, rheumatoid arthritis, ulcers and degenerative diseases. In addition, it demonstrates anti-inflammatory, anti-viral and anti-microbial benefits.
Adding to the confusion is the fact that not all Uncaria tomentosa roots actually contain healing properties.
Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. The Ashaninka healers, or sancoshi, are able to actually “see” the good spirits hidden inside the root of the plant before they harvest them.
Some cat’s claw plant roots have the good spirits. Some don’t. If the good spirits are mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no apparent differences in the plants or the roots to the untrained eye, only certain cat’s claw roots possess the power to heal. And, for a very long time, only the Ashaninka tribal healer seemed to be able to identify them. They call the good spirit cat’s claw Saventaro, or “powerful plant”.
However, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they could “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to be important medicinal compounds called pentacyclic oxindole alkaloids (POAs). Research has learned that POAs provide powerful benefits for the human immune response.
Q. Why are good spirits, or POA’s, good for the immune system?
Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.
Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest m ore bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin that is secreted by macrophages. This macrophage-secreted interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals that are essential to an Activated immune system.
POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies. And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T cells, Suppressor T cells, and Killer T cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.
Q. Can cat’s claw and other plants in the rainforest really cure diseases? Isn’t that just folklore?
It’s folk use and modern science combined-plants have long been known for their ability to kill cancer cells. In fact, the National Cancer Institute (NCI) has identified over 3000 plant extracts that can kill cancer cells. More than 70 percent of these plants are found only in the rainforest.
Q. What is it about the rainforest that gives plants like cat’s claw these cancer killing compounds?
Most of the time when we talk about rainforests, we’re talking about the tropical rainforests. While other forests, like the old-growth temperate forests of the Pacific Northwest, also have high rainfalls and tall trees, the tropical rainforests located near the equator are where most plant medicines come from.
The Amazon rainforest in South America is the world’s largest, covering an area about two-thirds the size of the continental United States. Depending on the elevation and distance to the equator the Amazon rainforest receives between 160 and 400 inches of rain per year. The rain is spread pretty evenly from January to December-it’s always the rainy season-and the temperatures remain between 75-80 degrees Fahrenheit all year.
This fertile environment continually recycles itself. When leaves fall from the trees, flowers wilt, and animals die in the rainforest-all of the nutrients are recycled back into the roots of the trees and plants. Because the rainforest reuses almost everything that falls to the ground, the plant growth is amazingly rich in alkaloids and other medicinal compounds. Researchers think these compounds and alkaloids, like POAs, protect the plants from illness and insect attacks. These are the very same compounds that protect us from disease.
Q. When the Ashaninka harvest the cat’s claw roots, does it impact the rest of the plant?
No. The Ashaninka work intelligently to keep rainforest cat’s claw plants perpetually healthy. The Ashaninka employ responsible and innovative harvesting techniques to keep the plants alive and tribal members healthy. Individual cat’s claw plants are never completely harvested. Only one third of the lateral roots are collected at any one time to allow re-growth by the remaining root. Once a plant’s lateral roots have been partially harvested, that plant is left to regenerate, and no more root is harvested from it for 10 years.
Q. Why are the Ashaninka willing to share their cat’s claw?
They are generous people. The Ashaninka see no benefit in hoarding cat’s claw for themselves alone. They also want to make sure that the plant’s healing properties continue on. As their homelands continue to be destroyed by deforestation, rainforest peoples are also disappearing. There were an estimated ten million tribal and indigenous peoples living in the Amazonian Rainforest in 1510. Today there are less than 200,000.
Since the 1900’s more than 90 indigenous tribes have died out and disappeared. Each time a rainforest medicine man or woman dies without passing their arts on to the next generation, the tribe and the world loses thousands of years of irreplaceable knowledge about medicinal plants. With them, centuries of accumulated knowledge of the medicinal value of rainforest species have been lost.
A good example of the impact of this loss can be seen in cat’s claw. When European explorers began venturing into the Amazon River basin, t hey were skeptical of the stories the Ashaninka people told them of U. tomentosa’s amazing healing powers. But when the explorers became sick with colds, flu, or other illnesses, they harvested cat’s claw root for themselves and gave the plant a try. Sometimes the explorers got better when they used the cat’s claw root, sometimes they stayed the same.
Q. Why didn’t the cat’s claw root help all the explorers?
Because some cat’s claw plant roots have good spirits-POAs-and some cat’s claw plant roots have tetracyclic oxindole alkaloids, or TOAs. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all. All U. tomentosa plants look virtually identical, so it’s hard to tell if they have the healing POAs or non-helpful TOAs.
What makes cat’s claw identification even more challenging is the fact that plants with POAs one year will have TOAs the next. Cat’s claw plants seem to change their alkaloid chemotypes at will, an incredibly powerful accomplishment for a plant to possess. Harvesting of cat’s claw roots that contain POAs is very tricky. Unless the person gathering the root extract is an Ashaninka sancoshi. These medicine men know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root. When scientists studying cat’s claw discovered they could “see” presence of TOAs using HPLC technology, they were able to harvest cat’s claw root extracts with POAs that consistently helps people get and stay healthy.
Q. Do some cat’s claw root extract supplements contain TOAs?
Yes they do. And buying those products will only benefit the cat’s claw distributor; they won’t help you stay healthy. When cat’s claw root is harvested from the rainforest, responsible supplement maker examine the root with HPLC to make sure that only POA roots are collected. But, this identification of the chemotypes takes significant time and costs money. For these reasons, many cat’s claw distributors don’t include this important process in their harvesting. The POAs and TOAs are simply just mixed together and sold as a cat’s claw product with no mention of any alkaloid content on the label.
Q. Why should I avoid TOAs?
While the POAs in cat’s claw root extracts have numerous benefits to the immune system, the TOAs have different effects in the body, none helping the immune system cells. Most importantly, however, when POAs and TOAs are mixed together, the TOAs actually work against the POAs. TOAs reduce the capacity of POAs to beneficially modulate the immune system.
Q. How can I be sure the cat’s claw I buy is POA cat’s claw?
Read the label of the cat’s claw root extract product you are considering buying. If it does not clearly state that it is the high POA cat’s claw, then chances are that it’s not.
Q. What do the Ashaninka receive in return for the cat’s claw harvesting?
The Ashaninka and reputable distributors of cat’s claw root extract have established a mutual and ethical relationship. Both groups benefit from the sale of the plant material. Maintaining this relationship is important for both the tribe and the distributors.
The distributors are paying a fair price for the raw material directly to the tribe. No intermediary is involved. This payment covers the raw material itself, a license-fee for the k knowledge of the plant, and a guarantee (from both sides) of a lasting relationship. Payment is also made for the protection of the rainforest. No deforestation is allowed. The area where the cat’s claw materials are processed is also leased and payment is made for this, as well.
This arrangement allows the Ashaninka to make independent decisions in how to spend this income from sale of their cat’s claw plants. They have been able to make improvements in the tribe’s water supply and in their living areas. They are also able to obtain outside medical aid as needed and provide for education of their children.
The partnership with cat’s claw distributors has created a sustainable resource for the Ashaninka. The tribe has been able to not only preserve their rainforest, but also compete financially with unsustainable income sources offered by timber and agricultural firms.
Q. Why is it important to preserve the rainforest?
The most amazing fact about these impressive medicinal plants is the vast number that5 has yet to be discovered. In fact, the rainforest’s abundance is one reason it is home to so many healing plants. Within a four square mile patch of rainforest, you could see 1500 species of flowering plants, 750 species of trees, 125 mammal species, 400 species of birds, 100 reptile species, 60 amphibian species, and 150 different species of butterflies.
Unfortunately, not everyone looks to the rainforest for the same reasons. Many consider its real value in board feet and cultivated acreage. The forces pushing industrial development move quickly; experts estimate that we’re losing over 130 plant, animal, and insect species every day/ That amount to almost 50,000 species a year.
A combination of logging, petroleum interests, cattle grazing operations, and, of course, our own consumer appetites are putting pressure on rainforest resources. The consequences are sobering:
By leaving the rainforest intact, however, and harvesting its many nuts, fruits, oil-producing, and medicinal plants, the rainforest has more economic value than if it was cut down for timber or to make grazing land for cattle. If managed properly, the rainforest can provide the world’s need for sustainably harvested natural resources on a perpetual basis. That’s what the Ashaninka are doing with their cat’s claw harvesting.
The discovery of medicinal plants is dependent upon healthy rainforests. When an acre of tropical rainforest is lost due to deforestation, the impact on the number of plant and animal species lost and their possible uses is staggering.
We can all help the development of sustainable rainforest industries. By purchasing renewable and sustainable rainforest products, like POA type cat’s claw root extract, we are keeping rainforests alive and well. By benefiting from the innate wisdom of the Ashaninka people we are keeping ourselves just as alive and well. By honoring the science and the sacred of the world’s rainforests, like my friend the oncology nurse, the massive wealth and diversity will be there for generations to come.
Neurological Health and CoQ10
February 25, 2007 12:06 PM
Between 1946 and 1965, 78 million Americans were born, creating the largest number of children in U.S. history. This Baby Boom generation has greatly influenced the makeup of American society and undoubtedly w ill continue to do so. Thanks to good nutrition and health care, Baby Boomers are aging well and have an excellent life expectancy. For the first time in history, we have more people turning 60 every day, and record numbers of adults reaching their seventh decade. As a result, neurological diseases associated with aging, such as Parkinson’s disease, are becoming major health care concerns. The good news is CoQ10 has applications for neurological diseases, in addition to its better known use for cardiovascular diseases.
Q. What is CoQ10?
A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone (existing everywhere there is human life). CoQ10 is vital to the production of adenosine triphosphate (ATP). ATP is the energy-rich compound used for all energy-requiring processes in the body.
Q. Isn’t CoQ10 a supplement for heart health?
A. Yes, it is. Because the heart requires lots of ATP to meet its high energy needs, CoQ10’s function in heart health is well understood. Numerous clinical studies have demonstrated that when individuals with heart disease take CoQ10, their symptoms improve, sometimes quite dramatically. Supplemental CoQ10 improves the heart’s pumping ability, improves blood circulation, increases tolerance to exercise, and improves the heart’s muscle tone. CoQ10 also is a powerful antioxidant and protects heart tissue from free-radical damage.
Q. How does CoQ10 affect brain health?
A. CoQ10 works in the brain the same way it works elsewhere in the body: it’s essential to ATP production. Nearly all human cells contain tiny structures called mitochondria. Mitochondria are referred to as cell powerhouses because they produce cellular energy. Depending on what each cell’s job is. There can be several thousand mitochondria in one cell. If a cell needs a lot of energy, it will have more mitochondria. This explains why heart cells contain so many mitochondria; the continual pumping of blood requires continual ATP production.
The brain also requires huge amounts of uninterrupted energy to regulate, integrate, and coordinate ongoing nervous system transmissions. To meet this need, ATP production within the mitochondria of brain cells is vital. Since CoQ10 exerts such a powerful influence on heart cells in ATP production, it was a natural progression for scientists to wonder how it affects brain cells. Brain and nervous system research led to the conclusion that the same intracellular principles apply. CoQ10 is produced in the body to assist in ATP production. Without it, ATP cannot be produced.
The most important discovery regarding CoQ10 and the brain is that CoQ10, when formulated with certain ingredients, can cross the blood-brain barrier and enter the brain’s mitochondria. If large amounts of CoQ10 can get into the brain cell’s mitochondria, its ability to make ATP is greatly enhanced.
Q. What is the blood-brain barrier and why is it important?
A. The blood-brain barrier is a unique anatomical structure. The cells that make up the blood vessels that provide blood to the brain are extremely close together. This greatly restricts what can leave the bloodstream and enter the brain. While the blood-brain barrier protects the brain and spinal cord from potentially toxic substances, it also can be a significant obstacle to therapy of central nervous system disorders. Only substances with certain solubilities or those that have a transport system can cross the blood-brain barrier to a significant degree.
Obtaining optimal absorption of CoQ10 is difficult. The CoQ10 molecule is large and inflexible. The easiest and least expensive way to increase absorption levels is with the use of harsh solvents such as propylene glycol. However, at higher doses, these types of chemicals are considered dangerous (neurotoxic) to the person with a serious neurodegenerative disease. It is more difficult, as well as more expensive (considering raw materials, research, and proper manufacturing methods) to promote absorption with less harmful alternatives. However, reputable companies ensure that their products are safe for all their customers. Look for CoQ10 products formulated with vitamin E and other safe ingredients such as Micosolle.
Nearly all CoQ10 supplements enter the bloodstream. But, only CoQ10 supplements with special formulations have been scientifically shown to enter the mitochondria and cross the blood-brain barrier.
Q. If CoQ10 is made in the body, why take supplements?
A. While CoQ10 is synthesized in the body, these levels may be insufficient to meet the body’s requirements. Researchers have discovered CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. They also have determined some medications significantly reduce CoQ10 levels in the body.
Although CoQ10 exists in some dietary sources, it may not be realistic to obtain CoQ10 through food alone. For example, it would take approximately 3 pounds of sardines, 7 pounds of beef, or 8 pounds of peanuts to equal 100 mg of supplemental CoQ10.
Q. How does CoQ10 help people with Parkinson’s disease?
A. CoQ10 seems to have several beneficial actions in the illness. Researchers have looked at mitochondria in brain cells and determined people with Parkinson’s disease have reduced activity of Complex I in the electron transport chain. Recent research has proposed the reduced activity of Complex I interferes with the brain-signaling chemical dopamine. Stored and newly synthesized dopamine is depleted. The dopamine depletion causes nerve cell degeneration.
A recent clinical study involved 80 patients with Parkinson’s disease (both men and women). The researchers first evaluated all the participants to establish scores for basic motor skills (measuring the ability to control physical movements such as walking), mental status (whether the person was depressed or experiencing memory loss) and the activities of daily living (whether the person was experiencing difficulty with handwriting, dressing themselves, using utensils such as knives and forks, and so on). This scale is known as the Unified Parkinson’s Disease Rating Scale (UPDRS). This process is known as establishing “baseline values,” that is, the condition of the patient before receiving any treatment.
Participants were divided into 4 groups. Each group received either 300 mg, 600 mg, or 1200 mg of the special form of CoQ10, or a placebo. The researchers observed the participants for 16 months.
The results of the study showed that all the participants who received CoQ10 had smaller declines in function compared to the placebo group, but the smallest decline was experienced by the group taking the highest amount of the special form of CoQ10.
The most significant results were noted specifically in the activities of daily living scores by the people taking 1200 mg of CoQ10 daily. These people retained better ability to feed and dress themselves, speak, walk, and bathe or shower by themselves. They maintained greater independence for a longer time. Parkinson’s disease, as with other neurodegenerative diseases, robs the sufferer of their ability to control the movements of their own body and care for themselves. Supplementation with CoQ10, while not a cure, is the first intervention that showed a slowing in the progressive deterioration of the function associated with this disease.
Q. What were the results of clinical research on Huntington’s Disease?
A. A randomized, double-blind, placebo controlled study respected type of study, was conducted at the University of Rochester. All of the 347 Huntington’s disease (HD) patients were experiencing some HD symptoms, but were still in the early stages of the disease. The patients (who did not know which drug they were receiving) were randomly assigned to four different treatment groups: 25 percent received Remacemide, 25 percent received CoQ10, 25 percent received both, and 25 percent received a placebo, or sugar pill. The researchers, who also did not know which patients got which drug, watched and recorded their progress for two and one-half years. Remacemide is a new drug made by Astra Seneca that blocks the neurotransmitter glutamate in the brain, that has long been suspected of contributing to the death of brain cells in Huntington’s disease.
Unfortunately, in the CARE-HD study, Remacemide had no effect on the progression of the disease in patients in the early stages. However, the individuals who received 600 mg of CoQ10 per day experienced some slowing of the disease progression. They were able to manage daily activities, such as meal preparation, housekeeping tasks, and personal care longer than those not on CoQ10. They were also able to focus their attention better and were less depressed and irritable. The portion of the studied patients receiving 600 mg of CoQ10 per day experienced a 15 percent decline in the progression of HD. According to the researchers conducting the study, a 15 percent decline in the progression of HD would roughly translate into approximately one more year of independence for patients. This is the very first study from more than a dozen Huntington’s disease patient trails that showed any modification of the course of the illness.
Of note, the effects of the CoQ10 had not abated at the end of the research study. That is, the benefit of using CoQ10, 600 mg per day, was still increasing; this suggests that the longer a patient supplements with CoQ10, the greater the decline in the progression of HD. The next phase of the CARE-HD research will test a higher dose of CoQ10 (1200 mg or more per day), with more patients (over 1000), for a longer period of time (approximately 5 years). This study should improve our understanding of the optimal dose and the total achievable decline in the progression of HD. The CoQ10 product used in the CARE-HD study was designated an Orphan Drug by the FDA. The product utilizes a proprietary, patent-pending delivery mechanism, which is proven to be safe and tolerable at high doses for people suffering from neurodegenerative diseases, substantially improving brain tissue levels of CoQ10.
Q. What other diseases could benefit from CoQ10 supplementation?
A. Studies show CoQ10 levels are greatly reduced in Alzheimer’s patients. Mitochondrial abnormalities also are noted; however, research has yet to determine how or why this occurs. Some scientists believe damage to mitochondria is an early feature of the disease. Free-radical damage also is a feature of Alzheimer’s.
In a study of 27 Alzheimer’s patients, subjects were given 60 mg of CoQ10, 150 mg of iron, and 180 mg of vitamin B6 daily. Each patient’s mitochondria activity was effectively Activated. All patients continued to experience gradual decline. However, researchers believed that with this combination, the progression was much slower and allowed the patients to experience 1 to 2 years of extended good health.
ALS (also known as Lou Gehrig’s disease) is a progressive, fatal, neurological disease. It occurs when the nerve cells in the brain that control voluntary movement gradually degenerate. Investigation of CoQ10 in individuals with ALS is just beginning. Researchers at the Eleanor and Lou Gehrig ALS Center at Columbia University recently conducted a small clinical pilot trial of CoQ10 in ALS. The study was an open label study, which meant that everyone enrolled received CoQ10, 400 mg three times per day. Of the 16 patients originally enrolled, nine patients completed the study. Six of these nine patients experienced some benefits. The patients declined from 0 – 25 percent in functional scores, 6 percent in strength, and 10 percent in breathing ability. These scores reflect a positive trend compared to the 50 percent decline that is seen in the natural history of ALS over the same period of time (5 to 9 months). Citing the need to conduct more studies of the effectiveness of CoQ10 for people with ALS is rapidly and efficiently as possible to get answers to patients and clinicians, another clinical trial is currently underway at the Gehrig ALS Center. This is a pilot study to determine if CoQ10 has short-term effects on motor nerves in the brain using magnetic resonance spectroscopy (MRS). The researchers are going to try to “see” if CoQ10 can change the chemical sin the brain’s upper motor nerves of people with ALS, an important next step of the investigation.
Q. Can taking CoQ10 prevent neurodegenerative disease?
A. To date, there have been no studies or research examining whether CoQ10 can prevent these diseases.
Alzheimer’s disease prevention is being clinically investigated. Researchers have determined that people who take certain anti-inflammatory medications seem less likely to develop the illness. A large, multi-centered trial is studying this connection.
Q. How much CoQ10 should I take?
A. Depending on your family history of neurological disease and your disease experience, studies show benefits at doses of 100 to 200 mg of CoQ10 daily. Some studies used doses of up to 1,200 mg per day.
CoQ10’s safety has been evaluated. To date, no toxicities have been reported. Mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.
Q. What should I look for in a CoQ10 supplement?
A. Use products which have a strong clinical research track record, supported by product-specific research from reputable institutions, and have been proven to be safe, tolerable and effective in treatment of neurodegenerative diseases. The CoQ10 product you choose should be proven to: be absorbed, enter the blood stream, cross the blood brain barrier and increase mitochondrial levels of CoQ10. If the product you are considering does not have evidence to support these points, keep looking. Once you have found a candidate, examine the product’s safety and efficacy record for neurodegenerative diseases- if the product has not been proven to be safe and effective, keep looking. Good products exist; however, caveat emptor.
CoQ10 supplementation for people with neurodegenerative diseases is supported by contemporary clinical research. CoQ10 is certainly not the only answer to the complex issues of management and treatment of these types of diseases. However, research indicates that it is a bigger piece of the puzzle than physicians and scientists ever imagined. As we continue to study this naturally occurring compound, we are finding more and more benefits to the body.
All CoQ10 is not created equal. For safety and overall effectiveness, use a CoQ10 product that is supported by product-specific research from reputable institution, which is proven to be safe, tolerable and effective at high doses; deviating from this set of criteria may do more harm than good for people with these serious illnesses. Choose clinically tested products from a well-respected company and increase the potential to achieve and maintain brain and neurological health.
Q. What effect do the POAs from cat’s claw root have on our immune system?
November 22, 2006 01:38 PM
A. Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as cold and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.
Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest more bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin, that is secreted by macrophages. Interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals essential to an Activated immune system. (90% of white blood cells are in reserve)
POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies.
And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T-cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T-cells, Suppressor T-cells, and Killer T-cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.
European health care providers are often very comfortable integrating the use of herbal and nutritional supplements as vital components of their patients’ cancer treatments. In Austria alone, cat’s claw extract is used together with conventional treatment (chemotherapy, radiation, and/or surgery), to treat hundreds of cancer patients every year!
A recent clinical observational study looked at POA cat’s claw extract in 78 people with very advanced brain cancer. All of the participants reported that the special POA cat’s claw helped them feel better, have more vitality, and reduced side effects (such as nausea) caused by their conventional cancer treatment. The researchers felt that POA cat’s claw extract may also prove to have benefit in extending the life span of people with these types of deadly brain cancers.
The Important Role of Nutritional Magnesium & Calcium Balance in Humans Living with Stress
August 23, 2006 03:14 PM
Part I. The Stress Response
The stress reaction is a host of responses necessary for any animal to live in the world. Commonly called the fight-or-flight reation, we as humans often experience it in rapid heartbeat and increased breathing rate. It comes when we exercise more vigorously than usual, or when we are suddenly and unexpectedly frightened.
We are all different. We show a range in how strongly we experience the stress response. Most of us are usually calm and experience the stress response when an unexpected noise frightens us to alertness, or we run to first base as fast as we can in a benefit baseball game that is not on our usual playtime schedule. We breathe harder for a while and notice our hearts beating faster and harder then usual, but after a while these responses all calm down, and we are again in our usual state—out or the stress response. Others of us are very low key, and it takes a lot to disturb our physiological calm. Still others of us are very sensitive to triggers of the stress response and go into it “at the drop of a hat” and to a greater degree than do calmer people. For some, parts of the stress response are almost always engaged—never really calming down all the way—giving one a hyper-vigilant or anxious demeanor.
When a stress trigger occurs, the body puts out stress hormones, magnesium and calcium, among other things, into the bloodstream. At the same time, nerve cells begin to “fire,” telling heart and muscles to “speed up. NOW!!!” These blood, nerve and organ changes make possible the instantaneous and collective rise in the body’s heart rate, blood pressure, and other necessities for the fight-or-flight reaction.
Much research has been done on the stress response, especially on the effects of stress hormones, such as adrenaline (also called epinephrine) on body, organ and cell. You can get an idea of how widespread the stress response is-affecting every aspect of physiology—by noting some of the reactions to adrenaline, one of the major stress hormones. See Table 1.
Much study as the cellular, biochemical and physiological levels has shown that the stress response vitally involves the influx of calcium into cells, resulting in a drastic change in the cells’ internal magnesium-to-calcium ratio (Mg:Ca).
In simple solutions, such as salt water, all ions are evenly dispersed. Not so in living cells. Ions are carefully and meticulously separated in living cells, and this ion “packaging” is vital to life processes and health. Calcium ions, for the most part, are kept outside cells while magnesium ions are kept mainly inside cells. The stress response changes this. During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio. This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently. Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet comes as a team. For example:
Scientific study shows more and more that the underlying cellular change enabling the stress response is a low Mg:Ca ratio caused by a large and sudden influx of calcium into cells. This stress response subsides when the cell’s magnesium returns to its dominant presence inside cells, moving extra calcium back outside cells to its “normal” Mg:Ca ratio. This underlying principle is present in studies of nerve cell-stress hormone response, organs such as hearts, the high blood pressure response to stress, and the blood-clotting reaction during stress, among many others. See Table 2.
In the normal healthy state, the stress response occurs when necessary, and subsides when the crisis or trigger is over. Since magnesium and calcium—two essential nutrients that must be obtained by the body from its dietary environment—are so essential to this important response, it is not surprising that nutritional magnesium and calcium status can affect the response.
Let’s see how.
In the normal unstressed state, cellular Mg:Ca ratio is high. If this cannot be maintained due to lack of adequate body magnesium or an overwhelming amount of body calcium, the ratio may not be able to maintain or return itself to its healthy nonstressed ratio. In such a case, the stress response, in the absence of an appropriate trigger, can occur. This can be seen when nutritional magnesium deficits cause high blood pressure or increase blood stickiness (platelet aggregation). Additionally, since a low Mg:Ca ratio can increase adrenaline secretion as well as cells’ response to adrenaline, a too low magnesium state can keep the stress response from subsiding in a timely way. Even worse, when body magnesium becomes drastically low, this becomes a stress trigger in itself, alarming the body into further stress response with out enough magnesium to back it up, resulting in a low magnesium-high stress crisis that can end in sudden death.
In the industrialized world, we live in a state of chronic, on-going stress. This environmental reality increases our daily need for magnesium in order to maintain a healthy stress response that can calm when not necessary.
Part II. Heart Disease Is Often a Magnesium Deficiency
Clearly, an adequate amount of nutritional magnesium—in proper balance with adequate nutritional calcium—is key to a healthy stress response. And yet today we have diets dangerously low in magnesium. Add the recent additions of nutritional calcium via supplements and food fortifications meant to stave off osteoporosis, and many of us are getting inadequate magnesium plus too much calcium. This results in a large occurrence of heart disease.
Not all, but much of the heart disease in the industrialized world can be explained by the low magnesium state of these societies. People with heart disease—for the most part—are people who are in a state of magnesium that is borderline or deficient. Many studies on heart disease patients exist due to medicine’s effort to understand and treat this widespread malady. Although not intended as such, this body of research shows us what stress can do to a person in a magnesium deficient state.
Part III. Mental and Emotional Stress Deplete Magnesium
It is commonly accepted that certain traditional risk factors for heart disease exist. This include high cholesterol, high blood pressure, family history of heart disease, and other factors, all of which can be linked to a shortage of nutritional magnesium. Recent studies tell us that stresses—both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.
The sudden stress of the
Emotional stress and phobic anxiety cause heart problems in patients with heart disease—a population we know to be mostly low in their nutritional magnesium status. Chronic states of emotional stress, including a history of childhood abuse, neglect or family dysfunction, depression, and panic disorder, must now be added to the list of traditional risk factors for heart disease such as high blood pressure and high cholesterol. Depression can be a symptom of low magnesium status. So can anxiety, panic attacks, irritability, hyperactivity, and over-sensitivity to loud noises. Do these newly found risk factors cause heart disease, or are they risk factors because the, as well as heart disease, can all be aspects of low magnesium status? These chronic sources of stress can increase the human need for magnesium as well as be caused by its deficit.
Emotional stress triggers in susceptible people can even bring a sudden death due to heart attack, presumably by initiating a stress/low-magnesium crisis. Such emotional “triggers” include work stress, high-pressure deadlines, social isolation and loneliness, low socioeconomic status, anxiety, war, fear of war, anger and rage. Identical stress triggers cause more human heart attacks regardless of age, race, gender, or geographic location, including continent.
Mental stress, such as working out a math problem, can be shown to have impact upon the magnesium-stress response connection, since it can bring on heart attacks in people with heart disease.
Part IV. Stress, Magnesium and Aging
We are hearing a lot about stress in the health media, and rightly so as this constant companion to our lives brings on the fight-or-flight syndrome, a stress response that, when Activated, has been shown to shorten lifespan. When we realize that the stress response is exacerbated when we are low in magnesium, that we are living on low-magnesium foods for the most part, and that our lifestyles are more and more filled with chronic stresses and stressful events, we are not surprised to see that several aspects of magnesium deficiency are remarkably like aspects of the aging process.
When faced with out stressful lifestyles, coupled with a society presenting a chronically low-magnesium/high-calcium diet, what is our best defense? For many of us, magnesium supplements can help to preserve or restore a healthy Mg:Ca balance, so important to our health in these stressful times.
Peter Gillham's Natural Calm
Oxy Boost – Oxygenate your Life!
July 06, 2006 02:43 PM
Oxygen is the basis of all life and is found in the air we breathe and the water we drink. Increasing oxygen levels can have very positive effects, including improved mental clarity, endurance, immunity, better digestion and increased energy.
Oxygen is the key to a healthy immune system as well as every metabolic function in our bodies. Trillion of cells use oxygen to create energy every second of every day of our lives. Atmospheric pollution and deforestation play an important role in terms of the quality of air we breathe.
Oxy boost is all natural. It contains distilled water, sodium chloride (from sea salt), bioavailable oxygen, and essential and trace minerals. Oxy boost is the world’s premier stabilized oxygen supplement, containing one of the highest concentrations of Activated oxygen available today. It is pH balanced (approximately 7.4—a perfect pH for internal and external use). This is why Oxy Boost is so unique in the field of oxygen supplements.
Oxy boost has been proven in independent laboratory studies to be completely non-toxic in any concentration and at any amount. Oxy boost is safe to use both orally (sublingually or in water) and topically. Oxy boost does not depend on the digestive process to be absorbed.
The body’s first line of defense
A lack of sufficient oxygen in the blood stream reduces the body’s first line of defense. This has been clearly established in medical literature. Oxy boost safely increases the available oxygen levels in the bloodstream.
Works with other nutrients
Oxy boost can be taken with other nutritional supplements in fact; it may be safe to assume that oxy boost can even increase the efficacy of such supplements. Oxy boost works hand in hand with all other nutrients including amino acids, minerals and vitamins. These all require oxygen to be assimilated by the body and for utilization in the metabolic processes. The higher the oxygen saturation level in the blood and tissues, the more efficient and effective are the metabolic processes involving these nutrients.
We recommend that Oxy boost be taken on an empty stomach, preferably 30 min before eating or two hours after eating, to get the greatest physiological benefits from the product. Oxy boost is available in regular and therapeutic (2.5 times the concentration of regular Oxy boost) strengths.
This Amino Acid may help your heart… and your heart’s desire.
May 24, 2006 05:45 PM
Give all to love, obey thy heart,” cries the poet, and most of us have felt the link between our hearts and our passionate feelings. In the more reasoned language of science, what connects the heart with the heat of amore is blood flowing freely through relaxed, wide-open arteries.
That’s where Arginine comes in. This amino acid (protein building block) has stirred excitement because of its ability to improve blood flow. Scientists now think that one reason nuts promote heart health, in addition to their high omega-3 content, is because they provide plenty of Arginine (as do other high-protein foods such as meat, cheese and eggs), and supplemental Arginine has been linked to improvements in cardiovascular function. This nutrient is also under the microscope as a way to promote healthy sexual functioning in both men and women.
As often as we’ve heart the heart described as a pump and the blood vessels as pipes, the plumbing analogy doesn’t entirely hold. For one thing, arteries—those vessels that carry oxygen and nutrient rich blood from the heart to the body are dynamic creations, with muscular walls that can narrow or widen as needed. One of the chemicals that control this process is called nitric oxide, and Arginine plays a crucial role in nitric oxide production.
Because the body can create its own stores, Arginine is classified as a non-essential amino-acid. However, scientists now think that getting a supplemental supply (in the form of L-Arginine) may be best for optimal well-being. In a well-designed multinational study, for example, men with high cholesterol who took l-Arginine experienced drops in both blood pressure and homocysteine, a substance associated with heart attack and stroke (Journal of nutrition 2/05). And a research team at UCLA believes that combining l-Arginine with such antioxidants as vitamin C and E may reduce inflammation that can lead to blocked coronary blood vessels.
Arginine’s ability to stimulate bountiful blood flow supports enhanced intimacy, which is both genders depends on a fully Activated circulatory system. In fact, Arginine’s effects on nitric oxide are similar to those of Viagra and comparable drugs except that Arginine “is much less dangerous,” according to nationally noted herbalist Ellen Kamhi.
Men and women experiencing sexual dysfunction enjoyed greater levels of satisfaction after taking an Arginine based supplement, and the ladies reported having better relationships with their partners. What’s more, Arginine has helped infertile men by making sperm stronger and healthier.
Arginine may also help keep things pumping smoothly as the gym. It promotes the release of human growth hormone, which helps muscles grow bigger, and boosts the production of creatine, which serves as a power pack for high-intensity sports. What’s more, Arginine helps the body rid itself of ammonia, a toxic byproduct of physical activity. The amino acid’s ability to enable protein creation aids not only athletes but also people recovering from wounds, including those associated with surgery and burns. (note: the herpes virus that causes cold sores thrives on Arginine; avoid supplements if your having an outbreak.)
When the mind is willing but the body falls short, let Arginine unleash your potential. –Lisa James, Energy Times.
Benefits of L-Carnitine
February 12, 2006 03:24 PM
Potent Antioxidant Protection *
February 11, 2006 09:28 AM
Goji berry possesses a unique combination of flavonoids, vitamins, minerals and polysaccharides that are thought to be responsible for the antioxidant and anti-aging properties attributed to Goji. Studies have been conducted which characterize some of these antioxidant nutrients and show possible beneficial effects of the berry and its extracts on various systems and organs.
In a study published in 2004, scientists undertook an experiment to assess whether Goji berries contained compounds that would be known to exert potential beneficial effects on skin complexion and anti-aging properties. After analyzing the berry, leaf and roots of the Goji plant, they found that the Goji berry contained a unique analog of vitamin C known as 2-O-(beta-D-glucopyranosyl) ascorbic acid. They determined that this compound was unique to the berry and not found in the other parts of the plant. Furthermore, the vitamin C compound was present in levels equivalent to those found in citrus fruits such as lemons. However, the question remained as to whether this vitamin C analog served as a precursor to vitamin C when ingested in the body. A further experiment in rats was performed to determine the intestinal absorption and tissue uptake of this vitamin C analog. The results showed that some of the compound was indeed metabolized into vitamin C in the blood, while the rest was absorbed intact. These studies suggested that the compound was easily transported from the blood into cells and tissues, where it is Activated to active vitamin C. Therefore, the vitamin C from Goji berries seems to be highly absorbable and targeted for delivery to the cells that utilize it.1
Zeaxanthin is a carotenoid that is widely distributed in fruits and vegetables and, along with lutein, is present in significant amounts in the macula of the human eye. Studies suggest that the presence of zeaxanthin is highly desirable for healthy visual function. Goji berries are used in traditional Chinese herbalism to support eye health and are also known to contain a high level of zeaxanthin dipalmitate. Researchers compared the bioavailability of this naturally esterified zeaxanthin to that of an unesterified form in 12 individuals who underwent a 23-day study in which they received one form or the other, and then switched. Administration was done on day one followed by a three-week washout period. The individuals were then crossed over to get the other form on day 23 in a single administration. Analysis revealed that the esterified zeaxanthin from Goji berry caused a higher increase in plasma levels than the non-esterified form, indicating higher bioavailability.2
A second study confirmed these findings. In this study, fourteen individuals consumed 15 grams of whole Goji berries daily for 28 days. These individuals were compared to thirteen age and sex-matched controls who did not consume the berries. Fasting blood samples were taken for all individuals before and after the 28-day period. Results indicated that zeaxanthin plasma levels increased 2.5-fold in the group who consumed the berries daily, suggesting the high bioavailability of zeaxanthin from the berries.3
Goji berry was also studied on various measures of antioxidant activity. Researchers subjected three Chinese herbs, one of which was Goji berry, to various assays of reactive oxygen scavenging potential. The results indicated that all of the herbs had significant free radical scavenging properties; however, Goji berries showed the most potent scavenging effect in the assays. Goji berry was especially strong at inhibiting the formation of superoxide anion and scavenging free radicals. The researchers concluded that among these herbs, Goji could be considered the best antioxidant to promote healthy aging.4
An interesting study was performed in human skin cultures to determine the mechanism of the potentially protective effect of Goji berry extracts. Researchers found that bathing human skin cultures with an extract from Goji berry impacted the function of several enzymes that promote skin aging. This provides evidence of an anti-aging and antioxidant effect of Goji berry extract in these human skin cultures. Researchers also noted that when these skin cultures were subjected to suboptimal growth conditions (lack of adequate nutrients), supplementing the medium with this Goji berry extract allowed the skin to maintain normal metabolic functions.5 Goji berry extract contains numerous compounds that confer potent antioxidant protection to various tissues.*
AHCC® Fact Sheet - from Now Foods.
December 08, 2005 10:20 AM
AHCC® Fact SheetNeil E. Levin, CCN, DANLA 6/30/05
LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity.
KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound)
MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product.
AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and Activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system.
This formula is suitable for vegetarians and is offered in Vcaps.
SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach.
COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6),
PRODUCT SPECIFIC: None
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.
DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496.
Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315.
Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.
Immune Renew Fact Sheet
December 07, 2005 01:07 PM
Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)
MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.
ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels
SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.
This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
Effects of Cat's Claw on the immune system.
November 11, 2005 05:50 PM
Q. What effect do the POAs from cat’s claw root have on our immune system?
A. Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.
Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest more bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin, that is secreted by macrophages. Interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals essential to an Activated immune system. (90% of white blood cells are in reserve) POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists look at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies.
And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T-cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T-cells, Suppressor T-cells, and Killer T-cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.
European health care providers are often very comfortable integrating the use of herbal and nutritional supplements as vital components of their patients’ cancer treatments. In Austria alone, cat’s claw extract is used together with conventional treatment (chemotherapy, radiation, and/or surgery), to treat hundreds of cancer patients every year!
A recent clinical observational study looked at POA cat’s claw extract in 78 people with very advanced brain cancer. All of the participants reported that the special POA cat’s claw helped them feel better, have more vitality, and reduced side effects (such as nausea) caused by their conventional cancer treatment. The researchers felt the POA cat’s claw extract may also prove to have benefit in extending the life span of people with these types of deadly brain cancers.
Sytrinol can lower Cholesterol by 27% - 34%
September 20, 2005 09:56 AM
Sytrinol – MultiPronged Heart Health
According to the American Heart Association, more than 60 million Americans suffer from on of more forms of cardiovascular imbalances. When we add in those individuals with blood cholesterol concerns, we see over 100 million Americans who may be in need of specific diet and lifestyle recommendations for achieving and maintaining heart health.
Aside from the generalized recommendations that we typically hear for heart health (lose weight, exercise more, and eat less fat and more fruits and vegetables) There are a number of potentially beneficial dietary supplements that may help to maintain cholesterol levels in the normal range. Among supplements there is a wide range of safety and efficacy between products—but a newer product called Sytrinol stands out for its clinical effectiveness.
Sytrinol is a patented blend of polymethoxylated flavones (from citrus) and tocotrienols (from palm fruit). One of the factors that sets Sytrinol apart from existing natural products for heart health is its multipronged approach to controlling multiple factors related to overall heart health—including control of cholesterol, cellular irritation, oxidation, triglycerides, and others.
While it is unarguable that cholesterol is an important contributor to overall heart health, it couldn’t be further from the truth that cholesterol is the “only” or even the most important factor when it comes to protecting your heart. Did you know that approximately HALF of all serious heart challenges each year are experienced by people with NORMAL cholesterol levels? If Cholesterol is not to blame, then what is?
In addition to total cholesterol levels (the “number” that you may know as 200 to 240 of other values in “mg/dl” units), we know how that LDL and HDL matter a lot (Low-density lipoprotein—the “bad” cholesterol, and High-density lipoprotein—the “good” cholesterol). We also know that some forms of the bad and LDL can be “Badder” than others—specifically those with lots of structural protein called “apolipoprotein B” (which tends to encourage LDL cholesterol to become embedded in your blood vessel linings—bad!). In addition to our total cholesterol, LDL, HDL, and the various apoproteins, we also need to know our triglyceride levels, our levels of cellular irritation, what our free radical load looks like, and what our antioxidant defenses are. Sytrinol addresses each of these important aspects of heart and health simultaneously.
The Sytrinol Solution
Polymethoxylated Flavones (PMFs) in Sytrinol are just what they sound like – flavonoid compounds with extra methoxy groups compared to “regular flavones. Like all flavonoids, the PMFs deliver potent antioxidant activity, but the PMF version is about three times more potent in its ability to address cholesterol levels (20% - 30% reduction in clinical Studies). The two primary PMFs are nobiletin and tangeretin.
In addition to the PMFs, Sytrinol contains palm tocotrienols—one of the most potent antioxidant nutrients known. An interesting effect of tocotrienols is a reduction in cholesterol synthesis in the liver—by a mechanism similar to (but safer than) the commonly utilized mechanism of inhibition of the HMG-CoA Reductase Enzyme.
Sytrinol is known to work via several unique mechanisms to reduce triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). First, by reducing DGAT activity (Diacylglycerol acetyl transferase) and increasing liver PPAR (Peroxisome porliferator-Activated receptor)—Sytrinol can reduce overall synthesis of TG (DGAT inhibition). The overall effect is to reduce TG levels in the blood by two complementary mechanisms.
In terms of LDL effects, Sytrinol also reduces both Apolipoprotein B levels (ApoB—needed for the synthesis of LDL particles) and MTTP levels (microsomal triglyceride transfer protein-needed to transfer fat into the new LDL particles). By reducing levels of both these tructural LDL components, Sytrinol reduces overall LDL levels, and thus total cholesterol levels, in the blood.
The clinical results behind Sytrinol are impressive—showing a reduction in levels of total, LDL, and triglycerides by 27% - 34% within 4 weeks. In one of these studies, ApoB levels were reduced (suggesting reduced LDL) and ApoA1 levels were increased (suggesting increased HDL)—as would be expected based on the biochemistry of PMFs and tocotrienols.
Sytrinol is also wonderfully safe—and at the effective dose of 300mg daily, users will benefit from its multipronged effects. One aspect of Sytrinol safety that I especially like is the finding that, unlike some flavonoids like naringin from grapefruit, there are no known risks of drug interactions with the form of citrus derived PMFs found in Sytrinol (certain grapefruit flavonoids can interfere with liver enzymes needed to metabolize many prescription drugs).
Not since Red Yeast Rice was removed from the market by the FDA, have we had a truly effective, multimechanism solution for cholesterol control (and nearly total heart health). There are certainly other options for addressing heart health and cholesterol levels, but among the available choices, such as policosanol, guggulipid, niacin, and plant sterols, we’re looking at about half the cholesterol-lowering ability (10% - 15% in most cases) compared to Sytrinol. If youre in the “borderline” zone of cholesterol levels (about 240mg/dl and below), you should absolutely consider Sytrinol to keep your cholesterol levels under control.
Kurowska EM, manthey Ja. Hypolipidemic effects of absorption of citrus polymethoxylated flavones in hamsters with diet-included hypercholesterolemia. J Argic food chem.. 2004 may 19;52(10):2879-86.
Kurowska EM, manthey Ja, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, Tangeretin. Lipids 2004 feb;39(2):143-51.
Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL, Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human moncytes. J Nat Prod. 1999 mar;62(3)441-4.
Mora A, Paya M, rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Parmacol. 1990 Aug 15;40(4):797-7.
Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol exp. Ther. 2000 Apr;293(1):230-6.
By: Shawn M. Talbott, PH.D.
Disclaimer: The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
ANTIVIRAL PROPERTIES OF ST. JOHN'S WORT
July 15, 2005 09:25 AM
ANTIVIRAL PROPERTIES OF ST. JOHN'S WORT
As stated previously, hypericin has recently gained much of the medical world’s respect as an antiviral agent, with activity against a broad range of enveloped viruses and retroviruses. The effective virucidal activity emanates from a com-bination of photodynamic and lipophilic properties. A recent article in the journal Transfusion details exactly how hypericin works in inhibiting viral activity among cells:
Hypericin binds cell membranes (and, by inference, virus membranes) and crosslinks virus capsid proteins. This action results in a loss of infectivity and an inability to retrieve the reverse transcriptase enzymatic activity from the virion.14 Another recent study, carried out in 1991, focused on hypericin’s ability to inhibit virus activity, more specifically, in the murine cytomegalovirus (MCMV), Sindbis virus, and human immunodeficiency virus type 1 (HIV-1). The Sindbis virus was significantly more sensitive than the MCMV virus. The inActivated MCMV, when used to infect cells, was incapable of synthesizing early or late viral antigens. In addition to the direct virucidal effect, when hypericin was added to cells infected with viable MCMV, inhibition was also observed, particularly when the compound was added in the first two hours of infection. The researchers also indicated that the effect was aided significantly by visible light, pointing again to the plant’s photodynamic property.
The study states that hypericin appears to have two modes of antiviral activity: “. . . one directed at the virions, possibly on membrane components, and the other directed at virusinfected cells. Both activities are substantially enhanced by light.”15 And there are other viruses that fall under St. John’s wort’s antiviral blanket. Contemporary research points to the equine infectious anemia virus, the lentivirus, the Sindbid virus, the radiation leukemia virus, and most importantly, the human immunodeficiency virus (HIV).
HERBAL FIRST AID KIT
July 11, 2005 09:44 PM
HERBAL FIRST AID KIT
It is important to know the area where you will be going to determine plants that will be available in case they are needed and access to emergency help if necessary. The herbal first aid kit is meant to be used for minor conditions that may occur while traveling. Any serious condition should be seen by a health care professional. Gathering herbs along the trail can be fun as well as useful. Simple plant remedies can be brought along in the first aid kit. Major injuries require immediate medical attention by a professional. Minor problems can often be taken care of with simple herbal remedies. Supplies can be obtained from the local health food store or by collecting plants locally.
Along with the herbs, a few supplies should be part of the kit available at the local drugstore or market.
ALOE VERA: Aloe is great for minor skin abrasions, burns and as a natural laxative. It is excellent to soothe and repair damage from a sunburn. Aloe can be applied to stings and bites to soothe and heal.
TEA TREE OIL: Tea tree oil is a natural antiseptic and contains many antibacterial, antifungal and antiviral properties. It helps to speed the healing process and is excellent to apply externally on wounds to promote healing and prevent infection. It is also a natural bug repellent and can soothe and promote healing after bites and stings.
ECHINACEA: One of the most often used herbs, echinacea is useful for pre venting infection by stimulating the immune function. It can be found in herbal salve preparations and applied directly to the wound. A salve can also be applied to skin irritations from contact with poison ivy or oak. LAVENDER: Lavender is a natural bug repellent and can be applied topically to bites and stings.
GINGER: Ginger root is excellent for an upset stomach. It is effective when used to combat motion and altitude sickness. Studies have found ginger to be just as effective when treating motion sickness due to riding in the car, boating or flying in and airplane, as over the counter remedies which often have side effects such as drowsiness. Ginger can be made into a tea or taken in capsule form. ARNICA: Arnica can be applied externally to areas of bruising and swelling, but not to broken skin. It can help to reduce inflammation.
PLANTAIN: A poultice of plantain can help reduce inflammation when applied to the affected area. It can also help with bites, stings, scratches and cuts. GARLIC: Along with being a natural antibiotic to help prevent infection, garlic also helps to keep mosquitoes away. They don’t seem to like the scent of garlic. Capsules or pills should be taken internally.
CAYENNE (CAPSICUM): This is effective for both internal and external bleeding. Externally, apply pressure and raise affected area. Sprinkle cayenne powder over the wound. MINT: Mint leaves, often found growing in the wild, can be made into a tea to help with digestion and calm the nerves. Some members of the mint family include peppermint, spearmint, catnip and horsemint.
FEVERFEW: This daisy like plant found growing in the wild, can help with migraine headaches and inflammation.
Chew the leaves, make into a tea or take in capsule form. Some have developed mouth irritations from chewing the leaves.
Tea Tree Oil Fights Staph Infection
There is much concern regarding the overuse of antibiotics leading to drug resistant strains of bacteria. Some forms of bacteria are difficult to control as they change form. Tea tree oil holds promise as an effective treatment for inactivating Staphylococcus aureus.
A study reported in the Journal of Antimicrobial Chemotherapy, (1995; 35: 421-45), and lead by Dr. C. F. Carson, researched tea tree oil at the University of Western Australia. The results were significant. Tea tree oil successfully inActivated the staph bacteria which was resistant to methicillin, a salt of penicillin. It is a versatile substance with a broad spectrum of capabilities. It is generally used topically.
Blueberries for Health
Blueberries are packed full of nutritional value. A study published in the Food and Nutrition Re s e a rch Br i e f s , January, 1997, found that two-thirds of a cup of blueberries had more antioxidants than the recommended daily amounts of vitamins E and C. Blueberries were followed by Concord grape juice, strawberries, kale and spinach in their antioxidant content.
Antioxidants are an important part of optimal health. They protect the body from free radical damage which can lead to a variety of conditions such as aging, cancer, heart disease and other diseases. Adding blueberries could aid in p rotecting the body and strengthening the immune response.
Worldwide Concern About Antibiotic Overuse
A recent report called for doctors throughout the world to be careful in administering antibiotics needlessly. Overuse of antibiotics has lead to germ mutations resistant and untreatable with current antibiotics. Pediatricians in the United States have received a brochure from the American Academy of Pediatrics urging them to take precautions before prescribing. Antibiotics are not always the answer as they do not work on viral infections which cause the common cold, sore throats and some ear infections. Staphylococcus aureus is one example of an antibiotic resistant strain. Over 90 percent of this staph strain are resistant to penicillin and other antibiotics. And other bacteria are also developing a resistance to antibiotic therapy. Save antibiotics for conditions that require their use.
Aloe Vera, Woodland Health Series
Aloe vera is one of the most widely used plants for medicinal purposes. It has been used for over 4,000 year for its therapeutic benefits. Aloe Vera, a pamphlet written by Deanne Tenney, offers valuable information and up to date research on the aloe vera plant.
The benefits of the aloe plant are truly amazing. It has been used to treat burns, radiation burns, skin disorders, wounds, scratches, sunburn, dermatitis, constipation, digestion, ulcer, kidney stones, bacterial and viral infections, and to relieve pain. It is widely used for skin disorders, but its benefits go far beyond the skin.
As a natural home remedy, there are few plants more valuable than the aloe. It is a simple and easy way to treat minor injuries. The plant contains antiseptic, antiviral, antibacterial, anesthetic and tissue healing properties. The Aloe Vera pamphlet offers historical as well as modern uses for this ancient plant. Aloe Vera is available through Woodland Publishing.
Tea Tree Oil, Woodland Health Series
Tea tree oil is derived from the leaves of the Melaleuca alternifolia, a shrub-like tree found in Australia. It contains significant medicinal value and beneficial properties. Another pamphlet in the Woodland Publishing Health Series, Tea Tree Oil offers historical uses as well as current scientific information.
The essential oil of the tea tree leaves is one of the most powerful essential oils. It is used extensively in Australia, and popularity is growing throughout the world. It contains antibacterial, antiviral, and antifungal properties helping to prevent and heal infection.
Tea tree oil has been used successfully for many conditions such as athlete’s foot, acne, burns, warts, vaginal yeast infections, ringworm, skin rashes, herpes, cold sores, canker sores, insect bites and in preventing infection to name a few. Tea tree oil is a natural alternative that can be used effectively for extended periods of time without.
Guggulsterones - Natural Support for Cholesterol Health
June 29, 2005 10:44 AM
Today’s lifestyle, with its high-fat, processed food diet, lack of exercise, and high stress levels, leaves you at risk for imbalanced cholesterol levels. Source Naturals is committed to your optimal health and longevity. That’s why we developed GUGGULSTERONES. GUGGULSTERONES is a natural solution to help keep your cholesterol levels in the normal range. Guggulsterones are compounds found in guggul, the resin of a shrub used in traditional Ayurvedic herbalism to support a healthy heart. Research shows guggulsterones help maintain cholesterol levels in the normal range by helping to promote bile production, which removes cholesterol from the blood. They also boost thyroid activity, which supports cholesterol regulation by the liver. Source Naturals offers you natural guggul extract, standardized to provide a clinically effective daily dosage. As one of the most important botanicals to support cardiovascular health, GUGGULSTERONES is at the heart of Source Naturals’ commitment to empower people to take charge of their own health.
Cholesterol, Guggulsterones and Bile Production
Much of the cholesterol made by your liver is utilized to create bile, a substance used in digestion to emulsify fats. Because excess cholesterol and triglycerides are excreted from our bodies in the form of bile, it is important to support the liver’s bile-producing mechanism. Research shows that certain guggul compounds— guggulsterones—help maintain cholesterol levels in the normal range and act at the farnesoid X receptor (FXR) to promote bile production. Guggulsterones appear to be farnesoid X receptor (FXR) antagonists. FXR is a bile acid receptor. If FXR is Activated, this results in down-regulation of the amount of bile acids produced by the liver. Bile is made out of cholesterol, which gets used up when bile is produced. When bile levels are high, the production of more bile is slowed through negative feedback of the FXR pathway. As steroids, guggulsterones can enter the nuclei of liver cells and block FXR, which results in more bile production.
Guggulsterones and Thyroid Stimulation
Guggulsterones have been shown to stimulate thyroid activity in animal studies. This is important because 90% of individuals with sluggish thyroid glands also experience challenges to healthy cholesterol levels. Since the thyroid regulates the metabolic rate of many organs, when thyroid hormone levels are too low, the body’s overall metabolic rate declines. This impairs the liver’s ability to clear cholesterol from the bloodstream. The liver regulates cholesterol levels in blood as well as producing bile, and it contains thyroid hormone receptors. This is how the thyroid gland controls the metabolic rate of the liver. Several studies have shown that guggul supports normal cholesterol levels, including LDL, serum triglycerides, and HDL levels. Because normal levels of serum lipids, including cholesterol, are supported by increased circulating thyroid hormones, it is believed guggul works by stimulating the thyroid gland, in addition to its effects on bile production.
Clinically Effective Dosage
According to several clinical studies, the amount of guggulsterones used to maintain normal cholesterol levels is 75 mg per day, when taken with a diet low in saturated fats. This is the daily dose delivered by SOURCE NATURALS GUGGULSTERONES.
A Wellness Revolution in Cardiovascular Care
At a time when our cardiovascular health faces numerous lifestyle challenges, research into the remarkable heart-supportive properties of the plant world is critical. Source Naturals is your connection to this research, dedicated to quickly bringing you nutritional benefits now available only through the natural products marketplace.
Life Force - The Energy Activator
June 29, 2005 10:35 AM
Don’t Be Confused About Multiples – Get the Top-Ranked Multiple That Scores 100%
We can help you decide how to pick the most advanced daily multiple for your wellness. Listen to the experts. Source Naturals LIFE FORCE MULTIPLE was honored as a leading formula in an independent scientific analysis of 500 multiples, ranking higher than any other national brand. Lyle MacWilliam, author of the Comparative Guide to Nutritional Supplements (ide.com) ranked multiples based on criteria developed from the published recommendations of the most renowned nutritional authorities: Phyllis Balch, C.N.C.; Michael Colgan, Ph.D.; Earl Mindell, Ph.D.; Michael Murray, N.D.; Richard Passwater, Ph.D.; Ray Strand, M.D.; and Julian Whitaker, M.D. Source Naturals’ success in this rigorous scientific analysis reflects our Bio-Aligned™ formulation method. LIFE FORCE goes deep to the underlying cause of health imbalances by supporting multiple body systems. And now, based on the latest scientific research, we have improved the formula by adding even more antioxidants and other cutting-edge ingredients. According to Lyle MacWilliam, “Source Naturals made a top ranked multiple even better!” And based on Lyle’s analysis of the new formula, LIFE FORCE is now the highest rated multiple of any evaluated in the current edition of this guide, scoring a 100% rating.
Bio-Align™ Yourself with Life Force
LIFE FORCE MULTIPLE was chosen as one of America’s most elite and comprehensive multiples, as reported in the Comparative Guide to Dietary Supplements by Lyle MacWilliam, 3rd ed. LIFE FORCE received this acknowledgement by nutrition experts because it is uniquely effective. This Bio-Aligned Formula™ goes beyond ordinary multiples that simply replace nutrients missing from the diet. LIFE FORCE provides key organ-specific nutrients to support your body’s energy generation, heart, brain, immune system, musculoskeletal system, skin, liver, eyes, and more. When all your body systems function in harmony, everything in life comes together. Your mood is positive, your mind is clear, you’ve got energy in your step—that’s your LIFE FORCE working for you.
Get Ahead with Activated Energy and a Healthy Metabolism
Your metabolism determines how much you weigh, how energetic you feel, and the effective functioning of all your systems. LIFE FORCE is a rarity – a unique multiple containing an incredible number of nutrients at the potency levels that truly support your healthy metabolic function. For example, it contains coenzyme Q10, which plays a crucial role in cellular energy production. CoQ10 is a vital intermediate in the electron transport chain, one of the body’s energy production cycles, which converts glucose, or blood sugar, into ATP (Adenosine Triphosphate), a high energy molecule that is the body’s “energy currency.” LIFE FORCE also supplies alpha-lipoic acid and the potent R-lipoic acid form of lipoic acid, which are both referred to as the universal antioxidants and important intermediaries in the Krebs cycle, another energy production cycle.
LIFE FORCE also contains tyrosine and iodine, both precursors to thyroid hormones. These hormones regulate key metabolic functions like heart rate, digestive function, weight management and energy levels. No discussion of metabolism would be complete without mentioning the B vitamins and their coenzymated forms, such as thiamin cocarboxylase, riboflavin mononucleotide, and the methylcobalamin form of vitamin B- 12. These critical vitamins and their immediately bioavailable coenzymated forms are formulated to play critical roles in thousands of enzyme reactions that promote carbohydrate metabolism, energy production, and the mental functions that invigorate and activate you as you move through your busy days. And now green tea extract with EGCG (Epigallocatechin Gallate) has been added to the formula for added metabolic support.
Protect Your Heart and Circulatory System
The amazing muscular organ that is your heart beats more than 100,000 times a day, 365 days a year, promoting vitality and alertness by constantly oxygenating our tissues. LIFE FORCE supports your cardiovascular system with antioxidant coenzyme Q10, which helps support heart muscle metabolism. LIFE FORCE also contains the minerals potassium and magnesium, electrolytes vital for healthy heartbeat and heart function, and the herb hawthorn, a rich source of antioxidant flavonoids, which has traditionally been used as a heart tonic. LIFE FORCE also supplies vitamins B-6, B-12 and folic acid to help maintain healthy homocysteine levels and vitamin K to support healthy circulation. Unlike common multiples, it supports cholesterol wellness, circulatory health and antioxidant cardiovascular protection, with both the typical d-alpha form of vitamin E but and the more potent and effective gamma-tocopherol and similarly structured tocotrienols.
Skin and Musculoskeletal Support
LIFE FORCE furnishes nutrients to build healthy bones, muscles and skin. We all know that calcium and magnesium are crucial for bone health, but many people don't know that there are a variety of nutritional cofactors that help build bone, such as vitamin D (which enhances calcium absorption and utilization), boron, manganese and copper. LIFE FORCE also supplies vitamin C and copper, necessary nutrients for collagen production (collagen is a key constituent of connective tissue in joints, skin and other areas), and the cutting-edge nutrient methylsulfonylmethane (MSM), an assimilable form of the mineral sulfur, used by the body to build and maintain connective tissues, including joint cartilage, hair, skin and nails. Additional nutraceuticals to support healthy skin include DMAE bitartrate, CoQ10, and alpha lipoic acid. LIFE FORCE also now includes rutin, quercetin, green tea extract and 65% more turmeric extract for your joint comfort.
Brain and Nerves Nutrition
The hectic pace and constant demands of life can keep our pulse racing, our nerves jangling and our temples throbbing. Our nervous systems are crying out, “Help!” LIFE FORCE provides that help. LIFE FORCE supplies the most highly bioavailable and bioactive forms of the amino acid tyrosine – the N-acetyl form and the acetyl-L form. Tyrosine is an important precursor to epinephrine and norepinephrine (collectively known as the catecholamines), which helps you respond to stress. It also contains high doses of vitamins C and B-6, required by the adrenal glands to produce the catecholamines. In addition, LIFE FORCE delivers the full spectrum of B vitamins, all important for healthy nervous system function. Now LIFE FORCE also contains a more bio-available form of tyrosine, acetyl-L-Tyrosine. And LIFE FORCE contains Neuroceutical® nutrients that support healthy brain function by furnishing DMAE and choline. Both are precursors to the important neurotransmitter acetylcholine and are important for memory focus and muscular movement. Choline is also a precursor to phosphatidylcholine, an important constituent of the cellular membranes that surround and protect our brain cells. In addition, LIFE FORCE contains the renowned herb Ginkgo biloba and now even more grape seed extract, both effective antioxidants that can prevent lipid peroxidation, which is critically important for the high amounts of fatty tissue in the brain. LIFE FORCE—good food for the brain.
LIFE FORCE MULTIPLE supports your immune system, so you can feel your best through the seasons. LIFE FORCE contains the immunosupportive nutrient vitamin A, which fosters cell-mediated immunity and protects the epithelial linings of the respiratory and digestive tracts. Two forms of vitamin A are supplied: preformed vitamin A and its precursor, the potent antioxidant betacarotene. Other immuno-supportive nutrients in LIFE FORCE include vitamin B-6, vitamin C and zinc, which is fundamental for proper functioning of our T-cells, the “seek and destroy” cells of our immune system. LIFE FORCE also now includes 40% more lipoic acid, including the highly bioavailable alpha and R-isomer forms. Lipoic acid along with the B vitamins and CoQ10 promote building the energy reserves needed when the immune system needs to kick into high gear.
Powerful Liver Support
Your liver is responsible for converting many nutrients into their metabolically active forms before your body can use them. After activation, these nutrients travel through the blood stream to target organs where they perform their metabolic functions. Not only does the liver activate nutrients, but it also plays a crucial role in a variety of other metabolic functions, from fat digestion and cholesterol production to blood sugar regulation to the processing and elimination of toxins, an important role in today’s increasingly polluted world. For all these reasons, nourishing the liver is crucial. And LIFE FORCE does just that. LIFE FORCE contains alpha-lipoic acid, turmeric, silymarin and N-acetyl cysteine (NAC) – all potent antioxidants that support healthy liver function. NAC and alpha-lipoic acid both help produce glutathione, one of the liver’s primary detoxifying molecules. Silymarin, the active flavonoid complex of the herb milk thistle, as well as coenzyme Q10, have been shown in vitro to inhibit lipid peroxidation of cell membranes. Turmeric extract promotes bile flow and is a rich source of the antioxidant, curcumin. LIFE FORCE also contains choline and inositol, vitamin- like molecules which act as lipotropics, unique substances that prevent the deposition of fat in the liver. Since the liver is naturally high in fats, LIFE FORCE is one of the only multiples that contains the fat-soluble form of vitamin C, ascorbyl palmitate, for antioxidant protection.
Complete Antioxidant Defense
Oxidative stress is the primary cause of accelerated aging. This and other forms of free radical damage are constantly threatening your body. Whether it is from pollution, ultraviolet light, food additives, or from other sources, it is more critical than ever to protect your body with antioxidants. LIFE FORCE contains 24 of the most powerful antioxidants known to science, including eight new antioxidants based on the latest research. It contains antioxidants that are water soluble, such as quercetin and rutin, and ones that are fat soluble, such as alpha-lipoic acid and lycopene. There are antioxidants that are especially protective of specific body systems, such as lutein to protect the macula in your eye, lycopene to protect your prostate gland, and tocotrienols to protect your arteries.
Cutting-Edge Vision Nutrition
The structure and functions of your eyes are very complex. LIFE FORCE contains nutrients to help support and maintain healthy eye tissue, which is particularly susceptible to oxidative stress from free radicals. To support your healthy macula, aqueous tissue and optical nerve signals, LIFE FORCE includes ingredients such as lutein, astaxanthin, beta carotene, bilberry, zinc, lipoic acid and quercetin.
Life Force Replenishes Essential Nutrients to Support Your Low Carb Lifestyle
LIFE FORCE contains optimal levels of many nutrients that might be deficient in low carb meals. Counting carbs can lead to restrictions of nutrient-dense foods, such as dairy products, grains, fruits and vegetables. LIFE FORCE contains many of the same protective antioxidants, vitamins and minerals as fruits and vegetables, including betacarotene, vitamin C, vitamin E, flavinols, magnesium and selenium. It also contains high levels of the same vitamins found in grains, including all of the B vitamins, to support your body’s healthy energy metabolism. And it contains nutrients found in dairy products, such as calcium, potassium, vitamin A and vitamin D.
Support Healthy Fat and Protein Consumption with Life Force
Low carb lifestyles mean higher consumption of proteins and fats. Unfortunately, there are artery, heart, colon and many other health concerns associated with meals that are high in fat and protein and low in fiber and produce. However, the nutrients in LIFE FORCE can help you better process these foods when eating this way. LIFE FORCE contains high levels of protective fat-soluble antioxidants such as alpha lipoic acid, ascorbyl palmitate (vitamin C ester) and vitamin E to protect your body from the free radicals generated by consuming more fats. It also contains many nutrients for liver health, such as silymarin, CoQ10, NAcetyl Cysteine and turmeric to help support the fat metabolism your liver is responsible for. LIFE FORCE also contains a high level of the B vitamin biotin, which aids in fat, protein and energy metabolism.
Complete Energizing Nutrition
LIFE FORCE is the only multiple to target organ systems with specific nutrients and bio-botanicals, antioxidants and Neuroceuticals® for total body harmony and energy activation, system by system. Only this dedication to going deep to the cellular root of system imbalances can produce a multiple so effective that it is acknowledged in a prestigious scientific review, the Comparative Guide to Nutritional Supplements. A nutritional program with LIFE FORCE at its center can be an easy first step in joining the Wellness Revolution. The goal of this revolution is a long, healthy and fulfilling life. Allow yourself to feel your best, to achieve mental and physical harmony, to radiate energy and vitality. Feel your LIFE FORCE!
CLA and the Catabolic Cascade
June 22, 2005 09:49 PM
CLA and the Catabolic Cascade
Next fall, when you or a friend goes to the doctor to get a flu shot, notice how a low-grade fever starts. Notice how rundown you or your friend begin to feel for a day or so after the shot. It is as if you are dealing with a small portion of the disease. In some respects you are, but, in reality, the icky, yucky feelings we associate with sickness come from our body’s own response to an invasion. When the immune system goes on the o f f e n s i ve, it puts out hormones called cytokines. T h o s e cytokines cause fever and pain.
Doctors call this process the catabolic cascade. It is our body that produces it. An extreme example might have been when Jim Henson, the wonderful creator of Kermit the Frog, got an extreme bacterial infection. He died within about 12 hours. Although the bacteria caused some severe reactions, it was his body’s intense catabolic response that may have been the direct cause of death.
Cytokines are involved in more than just stimulating the immune system, they are involved in how the body accumulates fat, in how veins accumulate deposits and in how our body during disease can sometimes cause dangerous, rapid weight loss. CLA changes how cytokines work, but how it does it is not certain.
Here’s an example of why this is important: When young animals get sick, their immune systems kick into action. Besides contracting a feve r, the animals’ growth slow s . Furthermore, weight and muscle mass can be lost, not just because of loss of appetite, but because of degradation of muscle tissue. For a poultry farmer, this can be significant. In organized farms, bacteria can abound and young chicks often face sickness. Because their immune systems are firing, the cytokines can stunt growth and, accordingly, stunt the farmer’s profits.
Dr. Mark Cook was working on this dilemma in 1990 and jogging at the campus of the Un i versity of Wi s c o n s i n - Madison. During one of his regular exercise sessions, he began chatting with Dr. Pariza. As researchers do, they began talking about their work. They decided to collaborate, seeing if CLA had an effect on this problem.
In 1993, the scientists at the University of Wisconsin-- Madison injected rat pups with endotoxin, the substances bacteria produce to do their damage.40 This injection Activated their immune systems. They also did the same thing in two studies using chicks. In all three studies, the weight-loss was about half what it was during the other studies.
In a study published in 1994, re s e a rchers also injected endot oxin into mice. To some, they gave CLA, to others they didn’t After three days, the scientists weighed the mice and discove re d that those who also re c e i ved CLA in their diets lost much less weight. Indeed, after three days they weighed as much as the c o n t rol gro u p, which re c e i ved no endotoxin at all. The CLA - f e d g roup also had a much better appetite than those that re c e i ve d no CLA with endotoxin. They also had a higher muscle mass.41 Let’s repeat that. CLA gives a higher muscle mass in rats. Stop and think about the implications. Other studies have shown, and, we will get to them, that CLA also cuts the amount of food converted to fat. In an era of increasing battles with the bulge, CLA seems to show great promise. (That weight gain seems to be involved somehow with the immune system and cytokines indicates that working with cytokines may be how CLA affects body fat accumulation.) Yes, CLA can help cut the effects of immune stimulation, but does it do that at the expense of making our immune systems less effective? Does CLA affect how the body battles disease? Not from any evidence in any study. The 1993 studies measured several immune functions, and, if anything, the immune system worked better.42
Again, these are animal studies, not necessarily involved with how humans work. However, these studies involve more than one kind of animal, making it, again, more likely to be useful in humans.
Let’s speculate for a minute. When CLA cuts the catabolic cascade, doesn’t it make sense that the body would feel better, if only because the appetite is better? When CLA cuts weight loss, couldn’t that have immense benefits for patients suffering from long-term illnesses—including those illnesses that affect the immune system—who grow weak from a loss of muscle tone and from a loss of weight?
For the animal industry, of course, this nutrient clearly means better production methods and healthier animals. For those same animals, it seems possible to speculate that CLA may actually work as a growth factor for their young.43 For humans, this nutrient could mean feeling better and feeling stronger while the body fights off disease.
At the beginning of this booklet, we learned that CLA may be one of the most important nutrients discovered in recent years. The support for that statement should be clear. CLA, if the human studies hold true, could cut your risk for cancer, could lower your risk of heart disease, could help you feel better when you are ill, and improve muscle tone while decreasing body fat.
This research has one other interesting side effect. Cook says that during much of the research, graduate students helping in the work would continually report that animals were eating less. Indeed, the animals ate up to 30 percent less while gaining weight or helping the immune system.
If all animals in the world were fed CLA, and it cut feed intake by 30 percent, this would have strong implications on world starvation and feed efficiency. Especially in a world w h e re meat consumption may be growing. Cutting the amount of animal feed necessary to produce the same number of animals is vital. This, too, is a possible result of CLA.44