Search Term: " Cyokines "
Omega-3s are a potent way to treat depression without resorting todangerous prescription medications
May 17, 2019 04:01 PM
One can treat poor mood and depression without using pharmaceutical drugs. One of these approaches involves using omega-3 fatty acid. Foods rich in this fatty acid can help. It has been shown by many scientific studies that the risk of having depression is reduced when one takes foods rich in omega-3 fatty acid. Some of the means that have been identified as the pathways in which omega-3 fatty acids work is that they can make the CNS to release more serotonin, they can reduce the risk of an inflammation and also its severity, and they can stop phosphatidyl-inositol from releasing hormones that make a person to have depressive moods. The way omega-3 fatty acids do this has been found to be similar to the way anti-depressant drugs work. Omega-3 fatty acids have been found to counter the release of serotonin in the brain that trigger depressive moods and they also have effect on the release of cytokines in the heart that relates to lowering the risk of one having coronary heart disease. And fortunately, heart disease is linked to major depressive moods. So, omega-3 fatty acid is a powerful compound that can be used to treat both problems. But what researchers have not agreed upon though is the required dosage of omega-3 fatty acid that a person should take each day to reap these benefits.
"The fatty acids achieve their natural antidepressant effects through several means. Omega-3s can raise the activity of CNS seratonin, reduce the risk and severity of inflammation, and stop phosphatidyl-inositol from sending signals that bring about depressive moods."
Read more: https://www.naturalnews.com/2019-04-15-omega-3s-are-a-potent-way-to-treat-depression.html
Can aloe vera be used to treat sepsis?
May 10, 2019 10:42 AM
Aloe vera can be used for plenty of skin conditions, but new evidence suggests it could be used for blood infections, because of the metabolites in the plant. A Chinese and Japanese study looked at this using mice, and found that aloe metabolites suppressed inflammation, due to reduced nitric oxide level. This is important because sepsis harms the body's own tissues and organs, and can be fatal. Aloe also has other uses, such as skin care, warding off cancer, treating digestive issues, and lowering blood sugar levels.
"After using various tests to determine inflammation, the Chinese and Japanese research team found that aloe metabolites suppressed the expression of inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs). Aloe metabolites also decreased the production of proinflammatory cytokines and nitric oxide."
Read more: https://www.naturalnews.com/2019-04-17-can-aloe-vera-be-used-to-treat-sepsis.html
Corn silk and its anti-inflammatory and antinociceptive properties
May 06, 2019 02:57 PM
Corn silk has been used in ancient medicine in the Far East for several thousand years. It has anti inflammatory properties to help reduce swelling in organs as well as soft tissues and muscle. More research in recent years has found that it also has anti cancer properties and has a mild pain reducing effect for abdominal pain associated with gastrointestinal issues, gall bladder symptoms and general colon health.It has also been shown effective in helping to stablize blood sugars in those with diabetes.
"Earlier research has shown that corn silk plays a role in some biological activities like diabetes and cancer prevention."
Read more: https://www.naturalnews.com/2019-03-26-corn-silk-anti-inflammatory-antinociceptive-properties.html
Happier and healthier: Curcumin-rich turmeric can help easedepression and anxiety, researchers find
April 25, 2019 05:11 PM
Curcumin, the active ingredient in turmeric, can have benefits for mental health on top of its many benefits for cardiac and joint health and inflammation. Curcumin is believed to help reduce neuroinflammation — and the cytokines that help cause it — and moderate cortisol levels within the brain, while achieving more balanced levels of dopamine and serotonin. These actions may explain why a 2015 study indicates that turmeric supplementation can substantially improve the effectiveness of antidepressants in many people.
"Curcumin regulates levels of dopamine and serotonin in the brain, and it also decreases the markers of neuroinflammation, which is significant when you consider that inflammation contributes to mood disorders."
Read more: https://www.naturalnews.com/2019-03-11-curcumin-rich-turmeric-can-help-ease-depression-and-anxiety.html
Eating okra is an easy way to boost your immune system
January 15, 2019 04:38 PM
Okra, a popular vegetable in the Southern U.S. and Middle East, is a powerful immune boosting food that can help your body resist disease and maintain overall good health. In fact, studies using okra pods have shown that compounds in the vegetable can increase white blood cell counts in the spleen and trigger the secretion of infection-fighting cytokines. These findings point to the need for more studies on the polysaccharides in this green vegetable as a possible immunomodulator.
"Based on these findings, the polysaccharides in okra should be investigated for future use as natural immunomodulators."
Read more: https://www.naturalnews.com/2018-12-13-eat-okra-to-boost-your-immune-system.html
New study links negative mood with higher levels of inflammation
January 05, 2019 02:26 PM
New research from Penn State University has shown that being in a negative mood can be linked with higher levels of inflammation and may be a signal of poor health. Inflammation is a contributing factor to many diseases such as diabetes and cancer. These negative emotions include sadness, anger, and depression. 220 participants reported on their moods and blood samples were taken to measure the inflammation present in the body. This was the first study to research how the two are linked. The long-term goal of the researchers is that the information will eventually lead to insights into how interventions can improve mood and ability to cope with stress. That will in turn help break the cycle of disease associated with inflammation.
"New US research has found that a negative mood, such as feeling sad or angry, may be linked with higher levels of inflammation and may be a sign of poor health."
Read more: https://www.malaymail.com/s/1705392/new-study-links-negative-mood-with-higher-levels-of-inflammation
To Get Rid Of Inflammation, Avoid These 5 Foods Like The Plague
May 02, 2018 09:17 AM
Inflammation in the joints can cause tremendous pain that you certainly do not want to experience. Shockingly, it could be the foods that you are eating that is causing you to experience inflamed joints. What foods are on that list of foods to avoid at all costs? There are several that you should not eat if inflammation is of concern, but the five hee are among the worst that you should ensure yu avoid at all costs.
"You’ve no doubt heard about the growing gluten-free craze that’s sweeping the nation, and you probably have some idea that gluten is bad news for most people."
Read more: https://www.thealternativedaily.com/these-5-foods-direcly-cause-inflammation/
Cooling Brain Inflammation Naturally with Food
December 31, 2017 03:59 PM
Carbohydrates and oils cause inflammation. Staying clear of certain foods will help cool the brain and prevent inflammation. Processed foods are a likely source of inflammation. Fruits and vegetables are a very good source of foods that prevent inflammation. Brain inflammation seems to be the key to mental illnesses. Eating a healthy diet may improve these conditions and overall health. Refined sugar and oils are known to cause inflammation. More studies need to be done on how to reverse these conditions.
"As a psychiatrist passionate about the connection between food and brain health, I believe that the most powerful way to correct chemical imbalances in the brain is through food—because that's where brain chemicals come from."
Read more: https://www.psychologytoday.com/blog/diagnosis-diet/201712/cooling-brain-inflammation-naturally-food
Is chronic fatigue syndrome an inflammatory disease?
August 02, 2017 04:14 PM
Chronic fatigue syndrome has been a very controversial thing for many years. Experts have not been able to gain much insight when it comes to the cause of it. There is a new study out that puts forward the suggestion that it is actually an inflammatory disease. There are wide ranging symptoms which makes it quite difficult to diagnose. It is characterized mostly by debilitating fatigue. it is also usually accompanied by pain and difficulties in retaining focus.
"Characterized by often debilitating fatigue, and sometimes accompanied by pain and difficulties in retaining focus, CFS/ME affects between 836,000 and 2.5 million people in the United States, according to the Centers for Disease Control and Prevention (CDC)."
Read more: http://www.medicalnewstoday.com/articles/318714.php
Could Cannabidiol Be Used to Treat ASIA Syndrome?
July 28, 2017 04:14 PM
Auto immune disorders are on the rise worldwide. While many are of unknown origin, one such disorder - ASIA syndrome, seems to be brought on by the use of adjuvants, which are compounds that are added to vaccines to boost their effectiveness. This allows you to use a lesser amount of the vaccine substance, but can cause other problems. One solution that is being explored is the use of cannabidiol (and other cannabis related products. Cannabis related compounds seem to suppress the production of cytokines common to immune reactions, which in turn helps suppress the immune response.
"Cannabidiol (CBD) is known to safely treat a huge array of ailments and disorders, the most recent being ASIA Syndrome, an autoimmune disease that is steadily increasing in developed countries."
Read more: http://www.cannatech.news/2017/07/19/could-cannabidiol-be-used-to-treat-asia-syndrome/
New Research Shows Depression Linked with Inflammation
January 21, 2017 07:59 AM
Does your struggle with depression have you on the verge of exploding? Inflammation could be the reason why. Researchers study the connection between inflammation and depression. Backed by science, take charge of your inflammation and manage your Depression. Also, check out some inexpensive and easy ways to reduce your inflammation.
"But growing evidence supports that at least some forms of depression may also be linked to ongoing low-grade inflammation in the body."
How inflammation interferes with the formation of new bone material
One suffers from autoimmune inflammation when the immune system takes healthy cells to be foreign and fights them. This disease causes abnormal changes and growth in body organs; it can affect many or just one body tissue. Autoimmune inflammation usually runs in families. The main cause of the disease is not known, but theories usually rotate on factors like chemical irritants, drugs, environmental irritants and virus. Autoimmune inflammation interferes with the process of bone formation as the chemicals released by body cells increase blood flow resulting in warmth or swelling of the infected part. This swelling causes irritation of the joints and the bones cartilage wears down swelling the joint lining.With patients with autoimmune inflammation, there will be the erosion of the cartilage and the bone. It causes weakening of the bone which is as a result of deterioration of the bone structure and low bone mass. This increases the risks of fractures as the bone becomes more fragile. It affects the bone formation by reducing muscle forces on the bone which can cause paralysis. From the activation of cells and immune system, there is a production of inflammatory cytokines which induce the bone loss. This is because it causes local cartilage degradation and thus inhibits bone formation.
Bone remodeling highly depends on the balanced action between bone-resorbing and the osteoblast, in this process, an inflammatory process that would target the joint will affect the structure of the bone. This will result in impaired function of the bone and the destruction of bone tissue. OPC generally helps to lower the blood pressure, protect the brain, stop deep vein thrombosis, prevent oxidative and stop inflammation. The seed extract reduces anything damaging the joints and helps in immune regulation. They help stop the symptoms of collagen-induced arthritis. It helps in building of the backbone. It acts as antibacterial agents, preventing inflammable infections. Inflammation can also be prevented through exercises and stopping obesity. Modification of the diet and consumption of supplements will also help avoid inflammation.
Breathe. Exhale. Repeat: The Benefits of Controlled Breathing
November 22, 2016 02:59 PM
Some researchers believe that overcoming stress and depression may be as easy as breathing. Many studies have been done to test the effect of slow and steady breathing on the body. Scientists have found that people who practice breathing meditation on a regular basis are able to lower their stress hormones and cytokines that have an adverse effect on the body. So, the next time you feel stressed, just practice some deep breathing to help calm yourself.
"Controlled breathing, like what you just practiced, has been shown to reduce stress, increase alertness and boost your immune system."
Curcumin in the form of Turmeric has been used for over 6000 years
Curcumin is the active component of turmeric. It works as an anti-inflammatory to prevent cancerous cells from growing.
There is plenty of research showing curcumin's ability to stop chronic inflammation that have been linked to the aging process.
Remember, chronic inflammation = high risk of cancer rate.
If you are not currently taking curcumin, consider adding it to your daily vitamin regiment.
What are the Health Benefits of Beta-Glucans
December 22, 2014 04:54 PM
What are Beta-glucans?
Benefits of beta-glucan
Beta-glucans are use for cancer, diabetes, HIV/AIDS and high cholesterol. Beta-glucans are also use for boosting the immune system in people whose body defenses have been weakens by emotional or physical stress, chronic fatigue syndrome or by treatments such as chemotherapy or radiation. Beta-glucans are also used for ulcerative colitis, hepatitis, multiple sclerosis, aging, H1N1 flu, Lyme disease, allergies, fibromyalgia, ear infections, rheumatoid, asthma and crohn's disease.
What Is Lactoferon And How Can It Boost Your Health?
August 06, 2014 09:01 AM
What is lactoferrin
Lactoferrin is a bioactive milk protein, especially concentrated in both human and ox-like colostrum and has been sold for a long time as a wholesome supplement with, hostile to bacterial, against contagious, hostile to viral and safe fortifying exercises. However the work demonstrating its bone building properties shows significantly more prominent potential.
Bad tempered Bowel Syndrome (IBS) is the most well-known gastrointestinal issue in the United States, influencing 1 out of 5 individuals. Indeed, with a large number of individuals looking for help for this, the reasons are still not well caught on. Numerous look for regular course, when conventional techniques don't bring the help they require. Analysts accept a combo of physical and mental well being issues can prompt the entrails getting to be harmed, or delicate to specific stressors. This can prompt an issue with the data pathway between the cerebrum and the gut, bringing about modifying intestinal capacity.
Side effects of lactoferrin
Side effects could be a consequence of a contaminating or disturbance in the stomach and insides from microorganisms or other destructive creatures. One study demonstrated that individuals who had an episode of gastroenteritis were ten times more inclined to create touchy inside disorder. An alternate condition, called small digestive tract bacterial excess, is truly regular in individuals with IBS. An excess or change in the kind of microorganisms in the small digestive tract causes aggravation and indications of loose bowels, over abundance gas, weight reduction, and dietary lacks. Some gastrointestinal manifestations could be because of the abundance of yeast (candida). Intestinal candidiasis can result in indications of bloating, gas, the runs, blockage, and cramping, alongside exhaustion.
Lactoferrin helps the side effects by:
1. Tying to free iron drifting around. This is essential on the grounds that most microbes and candida need iron to develop. Free iron meddles with our resistant cell work, so this viably starves the destructive life forms while keeping our invulnerable frameworks solid.
2. Entering the microbes or candida and harming their phone layer. This will either murder them straightforwardly, or it meddle with their vitality and debilitate them.
3. Keeping candida from adhering to the coating of the digestive tract and uprooting it once it is appended.
4. Repressing the activity of cytokines in the gastrointestinal tract. Cytokines are proteins found in the body that cause aggravation.
5. Sustaining the digestive tract with probiotic properties, which additionally help with GI well being. Probiotics sustain the well disposed microbes that live in your digestive tract. An equalization of great to unsafe microscopic organisms is required to avert gastrointestinal manifestations
Manufactured prescription drugs applied for the treating Ostepenai or perhaps Osteoporosis can certainly simply just carry out 1 or perhaps one other these projects. Bisphosphonates Actonel, Boniva, Fosamax in addition to Calcitonin Calcimar, Cibacalcin, Calsynar, Miacalcin, Osteocalcin in addition to Salmonine modest the particular evacuation connected with old bone tissue by means of restraining the particular action connected with osteoclasts. These kinds of prescription drugs carry out nothing at all to help secure osteoclasts to produce brand new bone tissue progress. Raloxifene Evista in addition to Strontium ranlelate Protelos invigorates the particular progress connected with brand new bone tissue yet never restrain the job connected with osteoclasts of their operate connected with evacuating old bone tissue. So this overdue study displaying a new compound that could carry out both projects is actually quite energizing. To a new significant component of most of these prescription drugs get understandably real allergic reactions that will block their employment by means of a lot of folks.
Lactoferon has been indicated to be a characteristic solution for IBS. It ensures the coating of your gastrointestinal tract, help your safe framework, and support in destroying living beings that can result in manifestations. It has been named by the FDA as GRAS (for the most part perceived as sheltered) for the whole populace, even the individuals who are susceptible to grain and dairy
What Is Beta Glucan 1.3/1.6 And How Does It Improve Your Health?
December 16, 2013 11:58 PM
What is Beta Glucan
Beta glucan, precisely 1-3, 1-6-beta-glucan or Beta 1, 3/1, 6 Glucan is defined as sugar (glucose) or a naturally occurring polysaccharide that is extracted from bacteria, fungi, yeast and mushroom cell walls, the fiber of oats, rye, wheat as well as barley and cellulose from plants. It can well be described as an immunostimulant or immunomodulator agent which stimulates the body microphages to produce cytokines and fight disease causing pathogens in order to boost the immune system of the body.
Beta Gluan Source
Since beta glucan is got from natural food sources such as shiitake mushrooms, it is a natural way to enhance the performance of the white blood cells in fighting diseases. It helps in the reduction of the cholesterol level from the body and it is the key to a Low Density Lipoprotein, which is essential in boosting the immune system of the body. For individuals whose immune systems have been greatly lowered by HIV/AIDS, stress or other conditions, this supplement is the way to go in restoration of their immune systems
In addition, beta glucan acts as an anti-carcinogenic substance which reduces the risk of suffering from the much dreaded cancer disease. It is also essential in keeping diabetes, hepatitis and cardiovascular diseases at bay. Beta glucan also inhibits tumor growth and proliferation and Lyme disease
What are some Benefits of Beta Glucan
Broadly speaking, beta glucan improves the overall ability of the body to resist various infections such as burns, common cold, asthma, allergies, ear infections and multiple sclerosis, to mention but a few. It is also an effective weight loss dietary supplement, and given that weight loss is the current health and fitness mantra, the use for beta glucan has is rampant in the contemporary world. To add color to the already good package, it is has mild or no side effects depending on the user.
Health benefits of Bromelain and its mechanism of fighting inflammation
April 20, 2013 09:54 AM
Bromelain is a blend of enzymes found in the juice and the stems of pineapples and is often used as a health supplement to assist in various disorders and enhance overall health. Here are the health benefits of Bromelain.
Improved Heart health
Bromelain functions as a blood thinner by breaking down the fibrins thus helps prevent blood clotting. It allows blood to move more freely throughout the circulatory system. Thinner blood is linked with lower possibilities of stroke, cardiac arrest and other heart problems.
Improved Breathing conditions
Bromelain is linked to improved breathing conditions that occur as a result of thicker mucus like asthma. It has similar effects on mucus as it has on blood thus making mucus thinner and thus does not clog the bronchial tubes.
It serves as an immunity booster and helps certain immunity boosting receptors within the body. As a result it fortifies the immune response by improving the response of body's front-line immune defense called the T-cells.
If the pancreas is not very active, it may produce insufficient quantities of enzymes, making the food we eat just getting digested partially. Consuming a bromelain supplement might help to cure any resulting digestive complaints like stomach upset, heartburn, diarrhea or indigestion. It is especially effective when used in in conjunction with other enzymes such as amylase and lipase because of its protease functions.
An external application of bromelain might help getting rid of undesirable skin tissues in the third-degree burns. Bromelain could also reduce inflammation due to insect bites and their stings.
Bromelain helps decreasing congestion and the cough that comes with sinusitis. Its anti-microbial attributes may wipe out viruses and bacteria associated with sinus infections.
Relieves varicose veins and Hemorrhoids
Bromelain is used as a complementary medicine in treating chronic venous insufficiency, hemorrhoids and varicose veins.
Enhanced Acid-alkaline balance
Bromelain can help in balancing the acidity and also the alkalinity in the small intestine. The anti-bacterial effects of bromelain helps relieving bacteria-related diarrhea connected with E. coli attacks and inflammatory bowel disease.
Bromelain and Inflammation
While inflammation aids mending the entire body during an injury, excessive swelling can result in health complications and speed up aging. Bromelain is beneficial in treating inflammation. The mechanism of how bromelain fights inflammation involves the inhibition of many bio-chemical responses and reactions that induce inflammation. Treatment with bromelain manages and regulates the activity of various bio-chemical messengers referred to as cytokines in our body. These cytokines are the chemical substances that trigger inflammation. By inhibiting the activity of cytokines, bromelain reduces the impulses that induce an inflammatory reaction.
Bromelain also decreases the deposition of kinins, a by-product of inflammation and also prostaglandins, the hormone-like compounds found through the entire body Thus Bromelain assists fighting the majority of inflammation occurring after having a sports injury or after surgery, or from minor sprains and tendonitis. Certain kinds of arthritis which involve inflammation also benefits from bromelain, particularly in combination with some other typical anti-inflammatory medications.
Do you take bromelain daily? If not, why not?
What Are The Health Benefits Of Solaray Avena Sativa?
December 28, 2012 12:52 PM
Avena Sativa is a botanical that is used for food and as medicine. Commonly known as groats or oats, the plant is available as tea or as a liquid extract. Over the years, Avena Sativa has been used as medicine for improving the functions of certain body organs. This plant is beneficial in so many ways. Let us look at some of its benefits.
Calms the Nerves
Avena serves as a remedy for anxiety, stress and depression. It helps to calm the nerves and may be taken by an individual who finds it difficult to concentrate. It can also be used to relieve insomnia associated with stress and nervous irritation.
Improves heart health
Medical experts have revealed that Avena Sativa can help to lower the “bad” low density lipoprotein and cholesterol level. It contains ingredients such as beta glucan, a soluble fiber which is very beneficial to the body. Further more, Avena sativa helps to treat palpitation and various heart problems. Such benefits help to strengthen the heart and make it healthy at all times.
Avena Sativa helps to fight inflammation, thanks to a molecule called avenanthramides. This molecule helps to reduce the levels of inflammatory cytokines. When the levels of cytokines are high they raise the risk of chronic illnesses like heart diseases and diabetes.
Natural Sex Booster
Dr. Ray Sahelian, the author of “natural sex boosters, identified avena sativa as a mild sex enhancer. Hence, its impact on the libido cannot be pushed aside. As you can see, Avena Sativa has lots of benefits. It can boost hormone levels and stimulate cell growth. Since it is rich in minerals, it may help an individual who is suffering with the thyroid glands.
Meanwhile, you can opt for the Solaray avena sativa available at VitaNet (R), LLC
Elderberry An Immune Booster And More!
December 21, 2012 12:00 PM
Elderberry Flower And Fruitelderelder
Elderberries are fruit shrubs that are native to North America and Europe. Unlike other organic foods that claim to have medicinal benefits, elderberries have crossed the border of being just a folk medicine to becoming an authentic treatment for a host of ailments, as backed by scientific research and studies. Today, elderberry has become a popular medicine for prevention and treatment of diseases. It is available in powder, syrup, capsule, and extract form.
A Good Antioxidant
Elderberries contain carotenoids, flavonoids, anthocyanins and polyphenols. These are antioxidants that fight free radicals. Free radicals are naturally occurring as by-products of metabolism, but as a person ages the antioxidants that the body produces cannot fight these anymore, as aggravated by pollution, smoke, and radiation. This causes the death of cells, which hastens aging and makes the body vulnerable to diseases. The antioxidants that you get from elderberries can reverse this process, putting a stop to the damage caused by free radicals.
Makes Your Heart Healthy
The number one enemy of the heart is bad cholesterol or LDL. Bad cholesterols form plaques in the arteries, which increase the risks for heart attacks and strokes. Elderberries are known to lower the levels of LDL in the body, thus, prevent the occurrence of cardiovascular diseases.
Strong Immune System
Elderberry boosts the production of cytokines, proteins that send signals to the immune system. With a faster communication between cells when the body is under attack by virus or bacteria, immune molecules can take abrupt actions to travel to the site of the attack and fight it off. Therefore, even if the body is exposed to a contagion, it can recover with less damage because of a strong immunity.
As proven during the influenza outbreak in Panama in 1993, elderberry has aided in the hasty recovery from the virus. According to studies, the extract from the fruit contain glycoprotein that inhibits the replication of the virus, thus, stopping its attack. The high vitamin content in elderberries also helps in the prevention of respiratory diseases like colds, bronchitis, and asthma.
What Supplements Are Useful In Combating Blood Clots?
October 04, 2011 03:14 PM
Vitamins And Your Health
As we know for a fact, one of the properties of blood is its ability to coagulate in order to stop bleeding. This coagulated blood is commonly known as a clot. Blood clot is important to the body to prevent excessive bleeding and serves as a vital part in the process of inflammation and wound healing. However, if a clot occurs abnormally it can cause significant danger to the body. A blood clot can cause obstruction in the circulation and may result to life - threatening health conditions such as heart attacks, cerebrovascular accident or strokes and pulmonary embolism. It can also cause poor tissue oxygenation and perfusion which can damage the affected cells and might cause disability or inability to function of certain organs or body part.
There are many traditional modalities in preventing and treating abnormal blood clot formation. One of the most commonly used is the medication called Aspirin in low – dosage. This conventional drug is popularly prescribed by doctors to decrease the clotting property of the blood. However, in emergency cases, a surgical procedure may be deemed important to remove the blood clot which significantly interrupts proper blood circulation.
Aside from medications, there are many supplements that have the capacity to decrease the risk of abnormal blood clotting. These include supplements high in:
1. FISH OILS. Fish oils are rich in omega-3 fatty acid which has the capacity to thin the blood. Therefore, if the blood is not viscous, the pressure inside the blood vessel is lesser as well. A high blood pressure can cause damage to the walls of the blood vessels, thus activating blood clot formation. Also, a non – viscous blood can also better circulate into smaller blood vessels than that of a viscous blood, therefore, enhancing tissue oxygenation. Clinical studies also revealed that omega – 3 fatty acids can effectively decrease Thromboxane A which is one of the clotting factors found among platelets.
2. CHAMOMILE. This herb has an anti – platelet property. It has a mild to moderate effect in regulating clot formation.
3. GINGER. Ginger has many health benefits. One of its promising benefits is its mild anti – platelet property and its ability to dissolve fibrin. This herb is widely used as a supplement to enhance blood circulation all over the body.
4. CATECHIN AND QUERCETIN. These chemical compounds are classified as antioxidants. They can effectively reduce the adhesion property of platelets.
5. CURCUMIN. This chemical comes from the spice called turmeric. This is considered to be an anti – thrombotic, as well as a potent anti – inflammatory agent.
6. DEHYDROEPIANDROSTERONE (DHEA). This substance is primarily an anti – aging agent. However, studies reveal that it can significantly reduce the process of inflammation by preventing the substance that can generate inflammation within the veins, arteries and capillaries called Cytokines. With decreased production of cytokines, it will result to lesser coagulation and clumping of platelets and reduced movement of bad cholesterol or Low Density Lipoprotein (LDL) into the walls of the blood vessels, thus decreasing the chance of clot formation and atherosclerosis.
7. VITAMINS C AND E. These vitamins are important for preventing abnormal collagen – induced platelet activation by inhibiting the production of hydrogen peroxide. Vitamins C and E are also important in many enzymatic actions that regulate blood cholesterol levels.
How Does Serrapeptidase Support A Healthy Immune System, Regulate Inflammation, And More?
September 01, 2011 02:25 PM
What Does Serrapeptidase Do In The Body?
Serrapeptidase is an enzyme which is protein - digesting by nature. It is considered to be one of the types of proteolytic enzymes which consist of the chemical substance protease. This chemical is derived from a non - genetically engineered fungus of the family of Aspergillus. Serrapeptidase is a dietary supplement which may be isolated from Serrapeptidase oryzae and Serrapeptidase melleus. Studies have claimed that this dietary supplement is effective as an anti - inflammatory, respiratory aid, cardiovascular or immune support. Other names of Serrapeptidase include serration - peptidase and serrapeptase.
During the early 1990’s, Serrapeptidase was isolated from the microorganism Serratia marcescens which is a known human pathogen found in the digestive tract of the Japanese silkworm. Many studies have been conducted to uncover the medicinal purposes of this bacterial enzyme. In fact, it has been widely used clinically in specific areas of Asia and Europe primarily as an inflammation relief agent.
These are some of the uses of the enzyme Serrapeptidase:
1. ANTI – THROMBIC AND FIBRINOLYTIC. Serrapeptidase can significantly prevent the build – up of blood clots. These clots must not be accumulated to prevent thromboembolism which can cause life threatening health conditions such as heart attack and stroke. Aside from its ability to prevent clot formation, Serrapeptidase also has a good fibrinolytic ability. It can lyse or dissolve already – formed blood clots.
2. PH REGULATOR. This proteolytic enzyme is considered to be an alkaline metalloprotease enzyme. It can selectively act on specific biological systems and prevent the activation of immunoglobulin G and immunoglobulin A. These body chemicals are immune system factors which helps the body prevent from infections and illnesses.
3. GOOD PROTEIN DIGESTER. Clinical studies have revealed that Serrapeptidase has a very good ability to digest protein molecules and its substrates. This is the reason behind why Serrapeptidase can effectively dissolve protein – based tissues such as fibrins, blood clots, cysts and certain inflammations. The advantage of this enzyme is that it can dissolve unnecessary tissues without harming the normal living tissues.
4. PROFOUND ANTI – INFLAMMATIORY AGENT. Serrapeptidase can effectively prevent and reduce inflammation, thus reducing swelling and pain sensation. The mechanism of action is said to be that Serrapeptidase blocks the synthesis of pain – inducing amines. Another mechanism is that it can effectively inactivate pro – inflammatory chemicals known as cytokines. In fact, this chemical is one of the components of analgesic drugs in Europe. The positive effect of this enzyme is that it does not have any digestive side effects.
5. RESPIRATORY AID. This enzyme is also helpful in improving the health of the respiratory system. It effectively alters the elasticity and viscosity of the dense mucus in people with respiratory problem such as sinusitis, bronchitis, asthma, and pulmonary diseases. People who are taking this enzyme supplement have shown improved liquefaction and expectoration of the mucus, thus Serrapeptidase is considered to be an effective mucolytic agent widely used all over the world.
Serrapeptidase is generally safe. Clinical studies have revealed that the sources of this enzyme are non – pathogenic except of one strain known as Serratia marcesens. This strain is pathogenic to human body. It may cause hypersensitivity or any untoward signs and symptoms. Therefore, it is best to consult a doctor before starting such supplementation.
Can Nettle Leaves Help with Allergies?
July 12, 2011 12:48 PM
Nettle And Allergies
Nettle leaf is a traditional medication for excessive inflammation in many European countries. It is valued for its hollow hairs called trichomes, which work as a counter-irritant. In addition to its putative effect on allergic rhinitis or hay fever, it remains extensively used as a treatment for joint pain, muscle spasms, back ache, osteoarthritis, atopic eczema, gout, and other disorders induced by inflammation.
Urtica dioica is the plant species referred to as the common nettle or stinging nettle, from which nettle leaf is harvested from in general. It is an herbaceous shrub that grows up to 2 meters in height. It is botanically noted for its trichomes, which inject list of inflammatory agents into the skin upon contact. In alternative medicine, these organic compounds are processed to combat excessive inflammation.
Nettles enjoy a wide distribution in almost all continents, with the exception of Antarctica and South America. In particular, stinging nettle has been successfully naturalized in all regions outside the Frigid Zone. It prefers soils that retain moisture and receive high rainfall. Hence, it thrives well in tropical and subtropical regions. In temperate zones, it is often found in the wild and abandoned settlements.
Nettle leaf has had a centuries-old association with folk medicine of England, Germany, Sweden, and much of Northern Europe. It is mentioned in the Old English poem called Nine Herbs Charm, which describes the common nettle as a treatment for poison and infection. In Germany, herbal preparations that contain nettle extracts are among the leading adjuvant remedies for allergic rhinitis and joint pain.
Hypersensitivity disorder of the immune system in the form of allergies is a reaction to otherwise harmless substances called allergens. These reactions include eczema, hives, hay fever, asthma, anaphylaxis, insect bites, and even systemic allergic reactions. Modern herbalists have long employed nettle leaf for the prevention, amelioration, and cure of hay fever and related allergic reactions.
The hollow stinging hairs of nettle leaf are a natural source of organic compounds that are similar to the chemicals released by the body during allergic reactions, such as histamine and acetylcholine. It produces optimum results when applied directly, as is the case with topical creams and alcoholic tinctures. Allergies subside when these compounds are introduced to local tissues underneath the skin.
Extracts of nettle leaf contain phytochemicals that display anti-inflammatory activities when ingested. The exact mechanism of action is still under investigation. Based on initial results, researchers are positive that nettle leaf exerts an inhibitory effect on pro-inflammatory cell-signaling protein molecules known as cytokines, which are directly involved in hypersensitivity disorder, especially hay fever.
More importantly, nettle leaf has been observed to inhibit the transcription of tumor necrosis factor alpha, which is responsible for a diverse variety of inflammatory responses of cells and tissues. As a results, it downregulates the production of cytokines and interleukins incriminated in excessive inflammation during joint pain, back ache, food allergies, asthma attacks, and allergic rhinitis.
Using Cherries to Deal with Arthritis
May 25, 2011 03:41 PM
Call it what you will: arthritis, osteoarthritis, rheumatoid arthritis or gout - cherries can deal with it and enable you live and sleep more comfortably than without them. When the bones and lubrication systems of your joints become worn you begin to feel pain - not because your bones are grinding against each other but because of the inflammatory response of your immune system.
Your cartilage begins to wear and your body reacts to the damage first by activating cells already close by - macrophages, mastocytes, dendritic cells and so on, and then calls on the release of leukocytes such as neutrophils. Your blood vessels dilate to enable the large cells to get to the general area of the problem, and then leak to enable fluids to get right to the exact spot where they are needed.
With arthritis, the joint swells because of the above actions, and the synovial fluid can become infected and inflamed. The temperature around the joint increases in temperature to render it less attractive to invading cells and pathogens, and you feel pain because of the pressure on your nerve endings. Then you should take some cherry extract.
The activity of the cytokines and prostaglandins that are creating this situation is suppressed, and the temperature starts to drop. The blood vessels are contracted and the situation begins to return to normal. One more bout of inflammation successfully dealt with, and now that you understand what has caused it you will be better placed to get the cherry extract down your throat next time.
Buy It And Try It Today!
Fight Inflammation With Herbs from Planetary Herbals
June 02, 2010 04:39 PM
Our modern lives have untold benefits, as well as challenges. Our dependence on man-made toxic chemicals, junk food, nutrient imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health.
These lifestyles and environmental change can challenge immune health, so that the various components of the immune system are not able to carry out their protective functions. Or our immune systems can go into overdrive, often leading to a state called metabolic inflammation.
A Powerful Herbal Blend
Inflamma-Care is a potent, herbal response to the metabolic inflammation that can result from inappropriate immune response. The main component of inflama-care is the rhizome of the curcuma spicies, long used as a spice in India. Known worldwide as turmeric (curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines – inflammation messengers.
This world-renowned spice is supported by boswellia, which inhibits pro-inflammatory enzymes, and ginger an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skullcap, corydalis, holy basil, and hops.
Inflama-care also contains systemic enzymes to clear and protect the arteries and circulatory system. Systemic enzymes like bromelain and papain cleanse the bloodstream and enable the blood to flow smoothly. A free-flowing bloodstream helps the body by circulating important nutrients to the cells while clearing the body of wastes.
Immune Activating Mushroom
Planetary Herbals also offers you new Full Spectrum Chaga in 1000mg tablets and a 1:4 liquid extract. Preliminary studies suggest that chaga triggers immune responses and protects the cells with antioxidant activity.
Chaga is a mushroom that is found attached to trees like birch, alder, beach, and other hardwoods, throughout the northern latitudes. A polyphore, the mushroom looks somewhat like coal – a brownish black mass often seen in tree trunks. In China, Siberia, Finland, Japan, Poland and North America, ancient and native peoples have long known the benefits of chaga. In an acient treaties, the Chinese monk shen nog declared in 100 BC that chaga is “a precious gift of nature.”
In modern research, chaga has been shown to have 215 phytonutrients, including 29 beta-glucans. Chaga also absorbs a nutrient from the outer birch tree bark: betulin, a natural anti-inflammatory. Among the components in chaga are triterpenes, sterols, beta-glucans, flavonoids, melanins, polyphenols, saponins, lignin, amino acids, vitamins, minerals, and fiber. This fascinating combination of nutrients is being studied worldwide.
The PhytoDynamic Difference
Both inflama-care and full spectrum chaga are formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. The result: herbal products unsurpassed for quality and consumer satisfaction.
Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination
March 22, 2010 09:07 PM
Turmeric / Boswellia Complex
Our modern lives have untold benefits, as well as great challenges. Our dependence on man-made toxic chemicals, junk food, nutrient-imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health. These unhealthy lifestyles and environmental changes have set our immune system on overdrive, a state call metabolic inflammation. Planetary Herbals Inflama-Care is a potent, herbal response to these modern challenges.
The Inflammation Cycle
As toxins and stress begin to alter our body chemistry and change the function of vital tissues, our body reacts with metabolic inflammation just as if it were being attacked. This reaction may result in a perpetual cycle of chemical imbalances and suboptimal health. Yet metabolic inflammation is often below the threshold of perception, not noticed or felt for years after its starts. It is only much later that the altered biochemistry and the system imbalances that it generates are noticed.
A Powerful Herbal Blend Inflama-Care helps support the body’s natural response to metabolic inflammation. The main component of the formula is the rhizome of the curcuma species, long used as a spice in India. Known worldwide as turmeric (Curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines—inflammation messengers. This world-renowned spice is supported by boswellia, which inhibits proinflammatory enzymes, and ginger, an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skull cap, corydalis, holy basil, and hops.
The PhytoDynamic Difference
Planetary Herbals presents inflama-Care to help maintain the body’s biochemical balance and integrity. Inflama-care was formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. Thie result: herbal products unsurpassed for quality and consumer satisfaction.
March 05, 2009 01:31 PM
Inflammation is a normal part of the body’s defense against pathogens. The increase in body temperature, flood of toxic free radicals and inflammation-signaling proteins, and release of killer macrophage cells are the main signs of an inflammatory event that is the body’s long-established means of defending against a clear and present danger. This adaptive response can now become a cause for debilitating disease. It is even thought that the aging process may be linked to the very defense mechanism that keeps us healthy when we are young. As we grow older, our ability to regulate inflammation begins to diminish. Instead of protecting us, inflammation becomes silent and systemic, allowing degenerative disease to take root. The symptoms of silent inflammation are extremely different from acute inflammation of redness, heat, swelling, and pain, and can lie undetected until it has been around for far too long.
Silent inflammation causes the body to turn on itself, as its immune system begins attacking its own organs. Over time, inflammatory cytokines such as C-reactive protein, interleukin-6, and inflammation producing eicosanoids like prostaglandin E-2 and leukotrienes B-4, start to destroy tissue all over the body. In response to this attack, the body produces even more inflammatory cytokines and free radicals, which creates a self-perpetuating cycle. Silent inflammation damages arteries, destroys nerve cells and organs, compromises the immune system, and promotes cancerous growths. Despite how well they feel today, those with silent inflammation are on a fast track toward degenerative disease. On the good side, preventative measures that are taken today to reduce inflammation can prevent degenerative diseases like cardiovascular heart disease, cancer, diabetes, and Alzheimer’s tomorrow.
When there are equal numbers of good and bad eicosanoids, a state of wellness is able to prevail within the body. However, when they become chronically unbalanced, many problems result. This balance is, interestingly, highly dependant upon the level of insulin that is found in the body. High insulin levels, whether they are induced by sugar overload, the onset of insulin resistance, or the hormonal effects of excess fat, set the stage for systematic inflammation. As insulin levels climb, oxidative stress increases dramatically, causing the production of inflammatory cytokines. Along with being too high in refined sugar, the average North American diet is filled with inflammation-promoting fats and scarce in inflammation-reducing omega-3 fats; the consequence of this chronic fatty acid imbalance in an increase in systemic inflammation.
As inflammation rises, so does the production of cortisol, which is produced in the adrenal glands and is intricately involved in the body’s response to stress. In an attempt to reduce inflammation, cortisol increases blood pressure, elevates blood-sugar levels, and suppresses the immune system. This means that systemic inflammation produces chronically elevated levels of cortisol, which then place a heavy physiological burden on all organs, causing a dramatic increase on the risk of degenerative disease.
Fortunately, changing the balance within the body to favor the production of anti-inflammatory eicosanoids can be achieved through a conscious dietary change. By simply increasing your dietary intake of fatty fish, eating raw nuts and grains rich in healthy fats, and supplementing with a high-quality cold-pressed fish oil or flaxseed oil, and concurrently decreasing your intake of red meats, eggs, high-glycemic foods, and foods high in saturated fats, chronic inflammation can be reduced greatly. Vitamin supplements can boost ones antioxidant intake and help fight inflammation as well. Quality vitamins are available at your local or internet health food store.
December 19, 2008 12:35 PM
Inosine is a specific type of glycosylamine that consists of a base bound to a deoxyribose or ribose sugar. This type of glycosylamine is referred to as a nucleoside, others being adenosine, thymidine and cytidine.
It is available naturally in brewer’s yeast and major organ offal such as liver and kidney. It’s function in animal biochemistry is in the production of ATP (adenosine triphosphate), often known as the molecule of energy, that is essential for the generation of energy by the mitochondria in our body cells. It’s biochemistry is described below.
Inosine is synthesized as inosine monophosphate by means of a complex series of biochemical reactions. The inosine monophosphate is a precursor for adenine, a nucleotide and purine base that reacts with ribose to form adenosine. This is another nucleoside that can be phosphorylated to produce adenosine monophosphate (AMP), the diphosphate (ADP), the triphosphate (ATP) and cyclic adenosine monophosphate (cAMP).
Each of these is involved in the metabolism of energy in the mitochondria. Glucose undergoes a number of enzyme-catalyzed reactions in the presence of oxygen that ultimately breaks it down to water and carbon dioxide, plus at least 36 molecules of ATP via glycolysis and then the Krebs cycle. The ATP reacts with water to release energy and form ADP. The ADP can then be phosphorylated to produce more ATP. The starting point of all of this is inosine, and it is little wonder this nucleoside is used by athletes to help boost their energy.
Not only that, however, but adenine is also the precursor of amino and nucleic acids responsible for the generation of RNA and DNA, and it is also responsible for the production of many coenzymes. These provide other opportunities for its use elsewhere in medicine, and it has also been found to possess other medical properties that will be discussed later.
It was in the 1970s that inosine was first used to boost athletic performance due to its part in the generation of the energy needed by every muscle in the body. Its use began in eastern countries, although evidence at the time did not support the theory. Nevertheless, this did not deter its advocates, and inosine continued to be used by athletes, a practice that has now spread world-wide.
It has been found to be a metabolic activator, in that it supports metabolism through the generation of energy. Inosine has been used by power lifters for heavy weight training to increase the capacity of the blood to carry oxygen, and strength athletes, particularly of the Eastern Bloc, used it from the mid 1970s onwards.
Inosine appears to increase the natural ability of the body to handle strenuous workouts, although there is no scientific proof of this. However, those that use it claim an increased ability to carry out intensive training workouts and an improvement in their competitive performance. The nucleotide can penetrate the cell walls and get to where it is needed to take part in the metabolism of energy through the production of ATP.
Now, however, inosine has an entirley different application in medicine. Studies have shown that it could support those suffering from MS (multiple sclerosis) and strokes through its pereceived neuroprotective properties. It appears to promote axonal rewiring, where undamaged neurons appear to grow new connections with damaged areas of the brain, and undamaged neurons seem to branch out to replace some of the damaged neurons.
Inosine is also an intermediate in the production of uric acid through purine and purine nucleoside degradation. Uric acid is a powerful antioxidant, particularly in respect of peroxynitrite, a nucleophile that causes the type of axonal degradation that is associated with multiple sclerosis. It thefore helps in two ways: through the production of uric acid, and in promoting axonal rewiring that can improve brain function in patients.
Another potential medical use for the substance is based upon the discovery that inosine and related compounds can act as powerful anti-inflammatories through their effect on inflammatory macrophage proteins. Certain conditions can cause the release of these macrohages, and where it is an undesirable side-effect, inosine can be administered to prevent it occuring.
Inosine appears to inhibit the production of pro-inflammatory cytokines without inhibiting anti-inflammatory cytokines. It appears to do so extracellularly, although the effect can be reversed by the blockading of adenosine receptors. However, it is a convenient way of avoiding this sometimes serious condition, which is a natural function of the immune system, without affecting any other part of that system’s essential work.
It is not an essential nutrient, since it is synthesized biochemically, but a supplement of inosine is certainly worth taking if you want to increase your ability to carry out athetic exercise requiring a high energy output and increased blood oxygen availability. It also helps to reduce recovery time, and proponents of its use claim that it enables you to exercise at a higher level for longer.
Although the medical evidence for this is scant, not a lot of work has been done in trying to establish it, and those that use inosine in this way swear that it is effective. The theory certainly indicates that it should be effective in helping to produce more energy, and also that it should be able to make more oxygen available, and some athletes have been taking it for decades with excellent results.
There are no known side effects of its use, although pregnant women and nursing mothers are recommended not to use it, as with many other health supplements the pathology of which have not been closely studuied. As with any supplement, you are highly recommended to consult your own doctor or physician when taking any supplement, particular if you have a current medical condition or are taking prescriptive medicines.
If you are predisposed to gout, and some people are, the uric acid it produces can render inosine unsuitable. Uric acid reacts with calcium to produce the sodium urate that is deposited on the cartilage and tendons of the joints, particularly the big toe. It is a very painful condition, so those that have suffered gout in the past should not take inosine as a supplement.
Otherwise, its effect on your athletic performance might be academic!
Hyaluronic Acid can help Restore Joint Function
December 01, 2008 10:03 AM
Hyaluronic acid, also known as hyaluronan, is one of the main components of the extracellular matrix of connective tissue and joints, and is one of the main chemicals contained in the synovial fluid that lubricates your joints. Before we discuss how it can be used to help restore the function of damaged joints, let's have a look at what causes joint pain, and why joints can break down long before their time.
You might have heard that arthritis is an inflammatory condition, or that it is due to the immune system. This is true to an extent, and rheumatoid arthritis is an immune system problem, although osteoarthritis is a different problem altogether. Arthritis is not the only cause of joint pain of course, but is by far the most common cause. As already inferred, there are two forms of arthritis, each with a different basic cause.
Osteoarthritis is the most common form of joint disease, and is largely due to wear and tear, injury or can be hereditary. However it is usually initiated by damage, the joint surface becomes roughened and the bone around the damaged area gets thicker to compensate. A joint is where two bones meet, and not all joints move. You have the fixed joints in your skull, for example, and those between the ribs and the spine. However, arthritis generally affects the joints associated with movement, mainly the knees, hips, fingers, toes and elbows.
The ends of the bones are covered with a thin layer of cartilage, which can absorb shocks and both cushion the joint and allow the ends of the bones to move smoothly over each other. Round each joint is a membrane known as the synovium that is filled with the thick synovial fluid, which lubricates the cartilage. The bone ligaments hold them close to the joint, and prevent them moving too much and dislocating. Finally, the joint is completed by the tendons that attach the muscles to the bones they control.
Osteoarthritis causes a joint to deteriorate: the cartilage becomes rougher and wears, and the bone beneath the cartilage gets thicker. At the edge of the joint the bone tends to grow outwards, forming spurs and the synovium swells producing extra synovial fluid. This causes swelling and pain, and ultimately the joint can be damaged beyond repair. This process takes a number of years to reach a stage whereby pain and discomfort are felt.
Before that situation occurs, however, the joint tries to repair itself, and hyaluronic acid can take part in this process. It is mainly involved in the reparation of connective tissues such as cartilage, although there are other connective tissues which hyaluronan has been found to repair. These include skin, eyes and heart valves and hyaluronic acid can arguably be used to help repair all of them.
However, it is joint tissue with which we are concerned here, and hyaluronan is an important component of articular cartilage: the type of cartilage involved in movement (knees, hips, etc), as opposed the type that forms your nose or the external part of your ears. It is believed that injections of hyaluronic acid can help to repair damaged articular cartilage. However, osteoarthritis is only one of the two forms of arthritis. The other is rheumatoid arthritis, and this is much more sinister.
Rheumatoid arthritis is caused by the attack of your joints by your own immune system, although why this happens is unknown. The most likely theory is that certain infections trigger the immune system, and it then proceeds to attack the synovial joints. Cytokines are responsible for inflammation of the synovial fluid, which can also cause fever, loss of weight and appetite, and inflammation of the blood vessels.
The body tries to generate more synovial fluid which causes swelling round the whole joint, putting pressure on the damaged areas, and generating even more pain. The inflammatory response commences and the whole area becomes seriously painful.
The smaller joints are most commonly affected, such as the fingers and toes, but it can progress to the elbows, hips and the knees. The joints become red, swollen and finally too stiff to be used. The sinusitis eventually leads erosion of the joint and deformation.
Because hyaluronic acid behaves like the synovial fluid, it is believed that it can be used to treat both forms of arthritis. It is a glycosaminoglycan, an unbranched polysaccharide of the same type as chondroitin sulfate that is commonly used to treat arthritis. It can be used to increase the viscosity of the synovial fluid, and render a more effective lubricant.
However, it is in treatment of osteoarthritis that hyaluronan is most likely to find success. It is used to improve the viscosity of the synovial fluid, so providing increased lubrication to the joint and helping reduce the pain. In fact it not escaped notice that those who eat a diet rich in hyaluronic acid tend to live longer and look younger than those that do not do so.
Commercial preparations are currently in use or under evaluation for disorders such as glaucoma, fractures, and detached retinas, damage to cartilage, healing ligaments and osteoarthritis. These last three are particularly of interest to arthritis sufferers, and signs are that they are effective with many cases.
However, it has also been established that smoking cigarettes can negate the effect of hyaluronic acid, and excessive levels of Vitamin C can also degrade it. Estrogen treatment, however, can enhance its effect in repairing connective tissue. Zinc deficiencies have also been found to have negative results, so make sure that these factors are addressed if you are using hyaluronic acid to treat arthritis.
Something to keep in mind if you are taking hyaluronic acid orally is the size of the molecule. It is a very large molecule, and suffers from the same absorption problems as chondroitin sulfate. There are smaller hyaluronan molecule versions available if you can find them, that improve the absorption through the intestine, but if not then the dose will generally be greater than expected due to the low absorption levels due to the molecule being too large to be easily absorbed through the tissues into the bloodstream.
NK Immune Boost
September 25, 2008 03:59 PM
The immune system is the ultimate bodyguard that can prevent illnesses before it even takes hold in the body when it is properly taken care of. Immune impairment has become a major concern within recent decades among health professionals. The strength of the immune system directly influences the quality of health. However, it is often something that we take for granted. There are a lot of things that can interfere with proper immune function, including diet, stress, and level of activity. It is within our ability to create a health immune system for ourselves.
If we do something that makes us a little bit healthier, we will experience less disease and suffering. Each of us individually must do what is necessary to protect ourselves from common health threats that can occur if the immune system is compromised like heart disease, arthritis, fibromyalgia, gastrointestinal problems, AIDS, cancer, and many other illnesses. We will be able to avoid disease and the suffering it causes if we do what is necessary to keep our immune system healthy and balanced.
In order to understand how to fight against health problems in the best way, it is necessary to first understand the basics of how the immune system functions. The smallest components of the immune system are biomolecules, which are also called immune factors or immuno-regulatory molecules. The immune system fights against the potential health dangers by identifying and then eliminating dangerous and unfamiliar particles, which include bacteria and viruses. The immune system can very selectively discriminate between self and non-self, a trait that is extremely unique. It then destroys the foreign antigens and leaves itself alone.
Biomolecules called cytokines work to regulate and simulate the body’s defense system. Cytokines help to fight against foreign molecules, also called pathogens, by inducing the production of antibodies. These antibodies work to neutralize antigens and create immunity to them. Additionally, a functioning immune system remembers the foreign antigens that it has encountered before so that it can prevent or quickly defeat secondary attacks by the same pathogen.
There are many immunity agents that are found in the body. An antibody is a molecule of the immune system that is secreted into the blood and helps to fight against antigens like bacteria and parasites to help create immunity, Antigen are substances that stimulate the production of an antibody when it is introduced into the body. Antigens include toxins, bacteria, foreign blood cells, and the cells that are found in transplanted organs. Colostrum, antibody-rich milk, is produced by a mother during the first week of her child’s life. Cytokines consist of any of several regulatory molecules that are released by cells of the immune system and acts as a mediator in the generation of an immune response. Cytokines assist in the regulating and controlling of the immune system.
Interleukin is a type of cytokine which encourages the growth of immune cells. There are many types of interleukins, with three of the most common stimulating the inflammatory response, the growth of blood stem cells, and the production of helper T cells. Pathogens are agents that cause disease, while tumor necrosis factor is a type of cytokine that has anti-tumor properties. It affects blood vessels, therefore, regulating both inflammation and killing tumors. Lastly, white blood cells help to protect the body from infection and disease.
Keeping the immune system in tip top shape is very important. There are a variety of natural substances such as colostrum that can help the immune system function at optimal levels. Natural supplements are available at your local or internet health food store.
September 24, 2008 09:17 AM
Balance is crucial for a healthy immune system. A variety of stressors such as bacteria, parasites, pollutants, strong emotions, and improper diet, can cause the immune system to become imbalanced. If the immune system is weakened then it is less able to fight against invading antigens. Disorders and reactions such as allergies, arthritis, multiple sclerosis, fibromyalgia, lupus, Crohn’s disease and diabetes can also occur if the immune system is overactive and begins to fight against itself. However, if the immune system is healthy and balanced, the body will be protected and healed from foreign invaders. But if the immune system is under active or non-responsive, it is susceptible to infection, illness, and emotional distress. By supplementing with natural immune modulators, the immune system can achieve and maintain optimum balance.
Cytokines consist of a variety of multifunctional molecules which work to regulate and control the body’s defense system. These biomolecules are crucial for optimal immune function as they play a key role in immunity, infectious disease, blood production, tissue repair, and cellular development and growth. Cytokines actually play an important role in a variety of body functions, ranging from general maintenance and the regulation of inflammatory responses to the direct interference of invading pathogens.
Cytokines are also important messengers that are used by the immune system to inform the rest of the body that an infection has been discovered. Any immune system imbalance can lead to interference between cytokines and proper body function. Different cytokines have different actions on the same cell. However, there is a large degree of overlap between the actions of one cytokine and another. Cytokines have been given a variety of names throughout the years including chemokines, monokines, interferons, interleukins, lymphotoxins, lymphokines, and leukokines. Cytokines are part of large signaling network that have additive, inhibitory, and synergistic effects.
The most important immune functions are carried out by groups of cytokines that are known as interleukin 1 and 2, interferons, and tumor necrosis factor. They help to modulate the immune system when the tissue is being threatened or damaged. Interleukin 1 helps to protect against the effects of radiation and encourage the growth of immune cells, while tumor necrosis factor is produced in response to bacteria and other disease-causing agents. Additionally, tumor necrosis factor also promotes the production of more cytokines. Tumor necrosis factor also has anti-tumor properties which increases the activity of other cells that fight tumors and also affects the blood system in tumors. It also effectively helps to slow down or reverse tumor growth by starving cancer cells of the nutrients they need and reducing blood flow.
Researchers are currently looking at treating various disorders with cytokines because it is clear that cytokines link the immune system to other physiological systems. Because of the intricate network of the cytokine processes, many researchers believe that the treatment of various immune disorders could potentially require a combination of immuno-regulatory factors. Many scientists are trying to recombining cytokines; however it is extremely limited because they are extremely expensive; they may be toxic and cause symptoms such as fever, muscle aches and fatigue; and they may create imbalances in the patient that would not benefit them.
As a result of these facts, researchers are turning their attention to a natural immune modulator such as hyperimmune egg and colostrum. Hyperimmune egg and colostrum can stimulate the production and activities of powerful immune agents and jump-start the body’s own defense system, instead of having to rely on drugs to fight invading pathogens.
August 13, 2008 12:44 PM
A lot of people are eating healthier nowadays, as empty processed diets are being restored to more wholesome foods, causing a more conscious society to be emerging. It is important now more than ever to understand how natural foods can help us to lose weight and create a better life. Spirulina is a small spiral-coiled organism that is one of the oldest living things on earth. Spirulina also called blue-green algae is a nutritional powerhouse and supplies numerous benefits. For centuries it has been nourishing people and is becoming an increasingly popular option among dieters and health seekers.
Spirulina thrives in hot climates where it grows in ponds and lakes, producing twenty times more protein than soybeans that grow on an equal-sized amount of land. It actually has the richest known protein content at 60 to 70 percent. This vegetable is easy to digest and allows dieters to meet their needs for this nutrient while fighting off the craving for meat, unwanted fat, and cholesterol. The concentrated protein found in spirulina can encourage natural body weight by eliminating the highs and lows in blood sugar that come along with a high-carbohydrate diet. This effect of stabilizing blood sugar helps people with hypoglycemia.
Spirulina was originally used for food by African villagers before the Aztecs recorded consuming spirulina in what is now Mexico over five centuries ago. In India, small amounts of spirulina were used to help improve the general well-being, by enabling vegetarian villagers to maintain a healthy weight without eating meat. Spirulina was rated a better food than most other protein sources by researchers at the Toronto’s McGill University when studying severely malnourished children. If you aren’t consuming the recommended servings of fruits and vegetables, just one spirulina serving can give you ten times more beta carotene than carrots.
In a study at McGill University, spirulina was given to thirty men with mild hypertension and high cholesterol; results were shown to reduce cholesterol levels in all participants. The total cholesterol levels dropped significantly, but returned to baseline when the spirulina was stopped. Spirulina contains gamma-linolenic acid, which is the same nutrient that is found in mother’s milk. When it is taken in large quantities, GLA has been shown to contribute to the prevention of cardiovascular disease and hormone regulation.
Scientists at UC Davis School of Medicine found that spirulina increases the production of cytokines, which provide a major defense against viruses and cancer cells. Cytokines are good for the body because they stimulate the cells that target cells which target certain pathogens. The more of these cells that you have available, the more attack forces you have to fight the cells.
The chlorophyll which is found in spirulina makes it a natural cleanser, as well as a natural appetite suppressant; making it favorable for dieters. This is extremely useful for people who are trying to lose weight or are fasting. Because spirulina is so rich in vitamin B12, iron, and magnesium, it is great for men, women, children, and vegetarians who are prone to deficiencies in these nutrients.
In conclusion, today’s spirulina is grown using modern methods and available in tablets, capsules, and powders. Spirulina is a great addition to one’s diet whether they are trying to boost overall health or manage weight. Stop in to your local health food store and ask about spirulina and how it can help boost your health.
Flax Seed Oil
August 07, 2008 01:53 PM
Flax seed naturally contains a variety of different categories of essential fatty acids, which includes alpha linoleic acid, linoleic acid, and omega-9 oleic acid. A lot of flax seed’s benefits are a function of its content of alpha linoleic acid, which is converted in the body to a longer chain of omega-3 EPA. Research has proven that supplementation with flax seed oil can help to increase the EPA concentrations in many tissues of the body. One of the main areas of research has been inflammation.
Many factors contribute to inflammatory reactions, including omega-6 linoleic acid, which can be converted into pro-inflammatory substances. Flax alpha linoleic acid can convert into EPA, which has the ability to convert into a prostaglandin that has anti-inflammatory properties. In inflammatory states, alpha linoleic acid and EPA compete with linoleic acid for enzymatic metabolism, resulting in a decreased production of pro-inflammatory substances. Many studies have found that the use of flax seed oil in domestic food preparation can reduce the production of inflammatory cytokines.
These studies have also shown the ability of omega-3 rich fish oils to inhibit inflammatory mechanisms in the autoimmune disease lupus nephritis, which lead to the investigation into flax having any abilities in this area. One trial found that 30g/d of flax seed was optimal for improving kidney function, decreasing inflammation, and reducing atherosclerotic development. Flax also contains antioxidants, which may be helpful to those who have SLE.
Research has also been conducted to investigate the hormonal modulating effects of ingesting lignans, which are antioxidant and phyto-estrogenic compounds that are found in flax seed. Clinical evidence indicates that phytoestrogens have an anti-cancer effect on the breast. Experimental studies in animals and humans have also demonstrated flax’s anti-cancer effects, with a 1998 review indicating that the consumption of flax may be used as a secondary prevention method against breast cancer. Flax seed has also been shown to promote prostate health, as it plays a key role in the treatment of an enlarged prostate.
The cardiovascular system is also another area of research focus for flax seed. One study showed that three months of flax seed supplementation resulted in LDL cholesterol levels dropping significantly, while HDL cholesterol did not change. Other research has shown serum lipid level reduction, but a large amount of flax seed was required to be consumed to get the same lipid-lowering effects as fish oils. Flax lignans also possess anti-platelet activating factor activity and antioxidant activity. Animal research has shown that flax seed reduced the development of aortic atherosclerosis’ by 46 percent and suppressed oxygen-free radicals.
The research concluded that dietary flax seed supplementation could prevent hypercholesterolemia-related heart attack and strokes. Lastly, the elasticity of arteries is an important factor of circulatory function, which decreases as the cardiovascular risk increases. Research has proven that obese people consuming a diet high in ALA from flax seed oil experience a marked rise in arterial elasticity, which reflects a rapid improvement in the arterial circulation.
Although flax seed offers many potential benefits, ingesting the right form of supplemental flax is crucial to gaining these benefits. Flax oil supplements are a good source of EFAs, but they do not provide great amounts of lignans. On the other hand, whole or ground flax seed is effective, but is not especially palatable. The best option of flax seed is the liquid in capsule form, as it delivers both EFAs and lignans. The nutritional value and certain beneficial results can be gained by consuming about 3,000 mg daily.
Fight Heart Burn
April 18, 2008 11:38 AM
In a search to promote a long and healthy life, a lot of Americans forget about their stomachs, which results in things ranging from simple heartburn to ulcers and even cancer. The effects of alcohol, smoking, and stress added to the rate of infection create the perfect conditions for stomach distress and disease. A combination of four nutrients: zinc, carnosine, licorice extract, and cranberry, work together to protect stomach function from the environment. These nutrients not only relieve distress, but they also support the body’s natural defense mechanisms against inflammation and the changes that can lead to cancer. A fifth nutrient, picrorhiza, protects the mucosa and can now be included as part of a natural gastric health remedy.
The human stomach, with its extreme acidity, provides a primary defense against infection and also helps in the first stages of digestion. A thick coating of protective mucus is steadily secreted by the surface mucous cells in the stomachs lining to continually protect its self from Hydrochloric acid. Almost everyone has experienced some kind of “upset stomach”, which we associate with overindulgence foods and stress. Although these are only thought of as mild annoyances, each episode causes a bit more lasting damage, which eventually results in cellular injury, which in turn causes inflammation. This inflammation then produces free radicals, which go on to create more tissue destruction and eventually damage DNA, thus potentially leading to cancers of the stomach worst case.
Many natural substances have been used around the world for thousands of years to promote stomach health. Modern science is finding that some of these “folk remedies” actually have potent effects on boosting immunity, reducing inflammation, and simply improving physical protection of the stomach lining. Zinc, a micronutrient that has multiple functions in human biology, mainly functions as a defender against free radical damage. It has been found that the more severe the inflammation in people is directly related to lower levels of zinc in individuals.
Zinc also helps to stabilize the membranes of cells that release burst of inflammatory cytokines when they are stimulated by injury or allergy. This mineral is also a well known immune modulator, which can reduce the recurrence rate of certain inflammation-sensitive cancers. There’s no doubt that zinc is a potent anti-inflammatory, and gastroprotective nutrient, but when it is added to amino acid carnosine, these effects can be boosted even further.
Certain fruits, cranberries particularly, are rich in anthocyanins, which have extreme antioxidant abilities. Other compounds that are found in cranberries also prevent bacteria from settling in the urinary tract. A review by nutritional experts found that regular intake of cranberry juice and other dietary products may be an alternative solution for those people who are at risk for H. pylori colonization. It also seems as though cranberries and there extracts can be placed alongside zinc-carnosine as an important component of an effective stomach health regimen.
Licorice extracts have also been shown to help fight stomach infection. Various studies have found that these extracts have potent anti-inflammatory activies, as they reduce cytokine production and increase the protection of the protective stomach mucus. These characteristics, when placed alongside those of zinc-carnosine and cranberry extracts, provide hope that a basis for an alternative therapeutic agent fighting H. pylori can form.
Picrorhiza, which is already used to speed healing in other infections such as hepatitis A, demonstrates unique wound-healing properties, stimulating tissue growth, nerve cell recovery, and blood vessel formation. Even though the multi-armed approach to gastric protection and improved stomach health seems to be complete with zinc-carnosine, cranberry, and licorice extract, picrorhiza extract brings together the infection-fighting, anti-inflammatory, antioxidant, and tissue-healing capabilities of multiple compounds, which all have complementary actions.
If you’re looking for a alternative approach to boost stomach health, the vitamins and herbs listed above are a great starting point. Please do not discontinued prescription medication from your doctor, some cases of stomach issues must be consulted with your doctor before discontinuing use.
Boost digestion with Bifidus Longum and Acidophilus Probiotics
March 21, 2008 12:19 PM
Prior to discussing how you can boost digestion with bifidus longum probiotics, let's first have a look at probiotics in general and why they are so beneficial to us.
Probiotics are also known as microflora, and are beneficial organisms that live in your digestive tract. Not all microorganisms are bad news, and many are essential for good health. Included in these organisms are various types of bacteria and yeasts, each of which has a specific part to play in the proper functioning of your body. Because of this they are found in foods all over the world, including yoghurt and fermented vegetables such as German sauerkraut and Korean kimchi.
Among their major benefits to health are that they help to support your immune system, they aid the digestion and absorption of food, they provide increased energy by improving the metabolic conversion of blood glucose to energy, and they can also help to delay aging. However, you should be aware that not all probiotics are the same, and when used properly some can have the same effect as antibiotics.
They are used to cure many digestive problems such as irritable bowel syndrome and diarrhea, and can also help to relieve heartburn and acid reflux. In fact your lower intestine should contain a minimum of 85% friendly bacteria, and 15% at most of unfriendly bacteria that can cause disease if they over-colonize your colon. It might surprise you to learn that you have around twenty times more bacteria in your body than body cells.
One of the best known of the probiotics are members of the lactobacillus family that are contained in yoghurt and curds and whey, so Little Miss Muffet had the right idea. However, you might not have the right idea in eating commercial yoghurt because, while raw yoghurt does contain these helpful bacteria, the type that you buy in pots in the supermarkets has likely been pasteurized - a process that kills off the bacteria. Unless the product has been seeded with live bacteria after pasteurization, then there will likely be none in your yoghurt! Make your own!
So what are the probiotics that do you most good, and in what form should you consume them? The common friendly bacteria are the already mentioned lactobaccilus, and then lactococcus, streptococcus thermophilus, enterococcus, bifidobacterium and others. Bacteria are easily killed off by the acidic conditions in your stomach, and since they must be taken live they should be consumed in a form that can resist the stomach acid.
There are many ways in which they benefit you, the main ones that are currently understood being:
Lactic acid production: the presence of lactic acid in the gut prevents stops or slows the growth of harmful bacteria by increasing the acidity. Some probiotics, known as lactic acid bacteria (LAB) can do this. Most bacteria do not like acidic conditions.
Supporting the immune system: LAB bacteria have been shown to increase the production of cytokines that stimulate the activity of the macrophages that attack foreign viruses and pathogenic bacteria. The LAB also promotes the formation of NK-cells (natural killer cells) that destroy cells that have been infected by viruses.
Adhesion site blockage: bacteria attach themselves to your intestinal walls at specific adhesion sites. Friendly bacteria can colonize these sites and so prevent the pathogens from adhering.
Effect on the Intestinal wall: the intestinal wall has a natural mucous barrier that helps to prevent the passage of allergens and pathogens into the bloodstream through the intestine. Probiotics can strengthen this barrier, and also alter the nature of the mucous to render it less liable to penetration by these unwelcome visitors.
So where does bifidobacteria come into this? There is a number of strains of this bacterium living in the human body, but Bifidus longum is the most common or most abundant of these. Although it is the most common bacterium found in commercially available probiotic products, high numbers have to be consumed for the proper health benefits. However, commercial yoghurts contain very little of this bacterium, or even none at all. This is largely due to the pasteurization previously discussed, that kills the bacteria at high temperatures. Unfortunately this process is not selective, and in ridding the products of bacteria that could make you seriously ill, the beneficial bacteria are also destroyed.
This is a shame because Bifidus longum has been shown to inhibit E.Coli that can cause serious conditions of the digestive system. Among these are severe diarrhea and an inflammatory condition in the colon as the immune system tries to expel these nasty bacteria. This bacterium is particularly dangerous to the weak, such as the aged, children and people already weakened by illness.
It also helps to counteract yeast and other vaginal infections and when taken with other probiotics is believed to help in colon cancer cases. Among its other benefits are its part in the biosynthesis of thiamine, riboflavin and other vitamin B forms in your intestine, and also the absorption and assimilation of these vitamins by your body. It is also believed that it might help to reduce the cholesterol level in your body through its uptake of bile salts from the colon.
The major destructive elements of Bifidus longus are antibiotics of any kind, whether they be penicillin variants or tetracycline, and although the latter is used mainly for infections of the respiratory tract, it is ingested by the gut and effectively reduces the population of the bacteria that are needed for optimum health. That is one of the reasons why antibiotic use should be restricted to only what is necessary, and not use indiscriminately for all infections. Unless administered intravenously or site targeted, antibiotics kill off the good with the bad!
The other activities of Bifidus longus, such as removing the by-products of our metabolism that could be toxic if left to roam our bodies, render this bacterium as useful to your body as any vitamin or mineral supplement you could take. It is a supplement that many either overlook or are not even aware of, yet one that can make a significant difference, not only to your digestive and intestinal health, but also to you general overall wellbeing.
Your Mouth Has A Lot To Say About Your Health
January 10, 2008 08:24 AM
For those of you have read every magazine article on improving your health and sex life, tried every trick suggested to you, and still have not found the solution, you may be missing one fact that most people don’t even consider towards improving their love life with better health. A woman’s sexuality has to do with a great variety of factors including both physical and emotional issues. Physical influences include hormonal imbalances, which play a major role. Most women experience the rage of this imbalance during pre and post menopause, as well as our menstruation cycle, commonly known as PMS. But most people have not considered one other important physical factor that is affecting their sexual mood, which is gum disease. Although this connection is rarely talked about and may seem odd at first, it becomes obvious how it all works when you learn the science behind it.
Throughout the different stages of our lives, our hormones fluctuate greatly. From puberty to pregnancy and menopause, many of our tissues are affected, which includes our gums. The gums can swell up, bleed easily, and even change color during times of related hormone events. Gum disease may be prevented with Coenzyme Q10 supplementation. Once the hormone balances, the hormones often do not go back to their healthy state automatically. If you practice good oral hygiene, your gums will go back to normal, but if not, it will stay the same or get worse with out proper nutrition and Coenzyme Q10.
Most people never realize that the slight bleeding of their gums during pregnancy or pre-menopause has anything to do with their hormones and nutritional deficiencies. Slight bleeding, red gums, and swelling are all signs of the inflammation that is associated with gum disease. Most people do not pay attention to the signs of inflammation when it occurs in the mouth, as gum disease affects 23 percent of women ages 30-54 and 44 percent of women ages 55-90. Proper nutrition may help reduce the number of individuals affected by gum disease.
Even the beginning stages of gum disease, which are known as gingivitis, can greatly impact your mood and health. If it is not treated, gingivitis will advance into chronic inflammation, leaving devastating results on your health. When your gums are not healthy, a great amount of events involving chemicals takes place both locally and systematically. These chemical changes trigger your immune system to respond, leaving inflammation on the gum tissue. During inflammation, immune cells release substances called inflammatory cytokines, which boost immunity but also induce dark moods in some people. If these cytokines stay too high for too long, they can even potentially trigger depression. Chronic inflammation leaves your body feeling tired and burned out. Unfortunately, a lot of people who have gum disease do not even know they have it. Except for the sign of slight bleeding when flossing or brushing, an unsuspecting person may not be aware there is tissue breakdown until it’s too late.
The solution to the situation is really simple. Taking 100 to 400 milligrams of Coenzyme Q10 to boost the immune system and help the body reduce its production of cytokines as well as boost energy. Coenzyme Q10 can improve periodontal health so be sure to consider the health of your mouth as an important part of your overall health. When you feel healthy, your sex drive is also healthy. If you’re feeling run down and have no interest in sex, make a visit to your dentist and have your gums checked. There is no excuse to not get regular dental check-ups and visit your local health food store to practice good oral hygiene and boost over all health.
Elderberry Can Boost The Immune System In The Winter
December 03, 2007 09:44 PM
The immune system is frequently overworked when the days get shorter and the temperature starts to drop, and elderberry can boost the immune system in winter for those that find themselves susceptible to all the colds, flu and other viral infections that seem to come out of the woodwork at that time.
Elderberry is the fruit of the elder tree that is native to Asia, Europe and North America. They are found just about anywhere due to their tolerance for a wide range of climates and soil types, and are frequently found by river banks. There are a number of different types of elder, in both small tree and shrub form, and it is those with the black and blue berries that are useful medicinally, not those with red berries. It is not only the berries that are used, but also the elder flowers. Elderflower wine has long been a favorite country wine, and the berries are used to make jam, pies and also drunk as juice.
Elder has been used for countless years for treating viral diseases such as influenza and colds, and it has also been found by some to be effective for the treatment of cold sores (herpes simplex). Its effect on flu is thought to be that it prevents the virus from entering and infecting the body cells, but more on this later. Historically, it has been used to promote the excretion of waste products through urination and sweating, which might be another reason why it is effective against colds and flu and some general respiratory problems.
The juice contains anthocyanins in the form of anthocyanidin-3-glycosides that appear to be very bioavailable to the body. The anthocyanins are more easily absorbed than those of blackcurrant juice, and are very strong antioxidants. The antioxidant effect is reinforced by the presence of large quantities of vitamin C. This difference in bioavailability has been proved though the administration of both blackcurrant and elderberry juice to volunteers, and testing the presence of the anthocyanins in the urine. This is a measure of their bioavailability, or how easily they are absorbed by the body, and the greater this bioavailability, then the more effective is their antioxidant effect.
Separate studies have indicated that anthocyanins derived from berries in general, not just elderberry, can reduce oxidative stress due to age, and also to help brain function. An improvement in the memory of the elderly has been seen to have improved after a course of berry juices rich in these powerful antioxidants. Elderberry antioxidants also improve the stability of LDL cholesterol by protecting against free radical oxidation, and thus helping to reduce the incidence of atherosclerosis that is promoted by the deposition of the oxidized LDL cholesterol on artery walls. This in turn helps to reduce the possibility of cardiovascular disease.
However, it is its effect on the immune system for which elderberry is generally studied by the medical professions. Elderberry helps to boost the immune system predominantly through the production of cytokines. To explain how these work, a quick summary of how part of the immune system works will first be necessary.
When intrusion into the body by an antigen (foreign body) is detected, the initial response is the inflammatory response. Chemical messengers called cytokines are released into the blood to inform the other parts of the immune system that an invader has been spotted.
The immediate effect is to increase the flow of blood to the affected part of the body by dilation of the blood vessels. The spaces between the cells in the vessel walls increase to allow the larger components of the immune system, such as the phagocytes that consume and destroy bacteria. Proteins also congregate and the temperature at the site rises to promote the reactions that the body uses to eject the invaders. The tissue therefore swells due to all the extra fluid and gets hot. The area becomes painful due to the accumulation of material aggravating the nerves, and if there is an infection, pus will eventually be formed from the dead neutrophils used to kill the bacteria or virus.
There are many different types of cytokine, including those that initiate the inflammatory response and others that stop the immune response once the invader has been killed off. Other cytokines, such as the interferons, stop viruses from multiplying, and others take part in the response only to specific types of antigen. Each cytokine has a specific message to pass to the relevant components of the immune system in order that the immune response is appropriate to the invasion concerned and does not overreact. Hence, a grain of pollen in the nose will elicit a lesser response than a varicella antigen that leads to those horrible chickenpox pustules.
In general terms, cytokines give the immune system a kick start once an antigen is spotted. The elderberry anthocyanins produce predominantly inflammatory cytokines, but also one anti-inflammatory cytokine, and so helping to boost the inflammatory response.
Some viruses use what are known as spike proteins that mimic the molecules of their host in order to gain access to cells by binding to the target cell receptors. However, these spikes are easily recognized by the immune system, and the elderberry anthocyanins are active in promoting this recognition. For that reason, viruses vigorously continue to change and mutate to overcome this, one manifestation of their success in achieving this being in the annual infections of influenza that have overcome last year’s antibodies by means of this mutation.
The influenza virus contains what are known as hemagglutinin spikes on its surface which, when deactivated, cannot break through your cell walls, enter the cell and replicate, thus leading to influenza. That is the mechanism by which the constituents of elderberries help to control influenza and reduce its effect on your body. If not deactivated, the spikes allow the virus to invade the cell and provoke the immune response that you know as the flu.
Many such winter ailments have a similar mechanism, which is why, apart from its general health benefits through its high antioxidant content, that elderberry can boost the immune system in winter.
Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?
November 10, 2007 11:29 AM
Inflammation, immunity diseases and allergic reactions are all connected with your immune system, and the way the body reacts to what it considers to be foreign invaders that are a risk to your health. Although you may not understand that all three have the basic underlying cause, in fact they do, and here is why.
Inflammation manifests as pain and swelling in the inflamed area, and not only can the area also get hot, but it can also raise your temperature in general, commonly called a fever. Fever is the body’s way of raising temperature above that at which foreign organisms such as bacteria and viruses can live, so any inflammatory condition that results in fever by definition must be an immune response through the body trying to eliminate foreign invaders.
If your body gets injured in any way, your immune system responds, and usually calms down again if decides that the injury is not serious. Your immune system is actually initiated by what are known as pro-inflammatory hormones, such as prostaglandins that stimulate the nerves to signal pain and swell the blood vessels close to the injury to make room for the large white blood cells when they arrive. That also allows blood and plasma to rush out and cause swelling at the site of the injury. Other prostaglandins act to quell the immune response, and get your body back to normal.
Another such hormone is a cytokine, which informs the brain of the intrusion. Some cytokines called leukocytes stop the immune system when necessary to prevent the destruction of healthy tissue, and also halt the inflammatory response. If the leukocytes are not working properly, the body can be severely damaged as the immune system becomes uncontrolled and starts to attack healthy tissue.
Then there are the histamines that allow you to expel the agents causing the problem by sneezing, watery eyes, runny noses and scratching. They lead lymphatic fluid and blood to the site of the problem in order that the invasion can be attacked and destroyed.
It is the histamines that provide what is commonly referred to as an allergic reaction, which is really the immune system coming into action to remove invaders such as pollen, dust mites and any other agent that can cause an allergy. Immunity is caused by introducing small amounts of the agent into the blood, so that the immune system can develop a memory of them. Then, when the same invader returns at a later date, the system can immediately attack them with the antibodies that have been produced.
All of these: inflammation, immunity and allergies, are caused by the reaction of the immune system to what it perceives as an invader. Normally these are bacteria and viruses, but sometimes they react to other foreign bodies such as pollen. In some people this provokes no response at all, while in others it provokes the immune system to create antibodies against the pollen, and emit histamine to expel it.
Substances that cause allergies are referred to as allergens. Many allergens are environmental, such as dust, pollen and peanuts. Some people are allergic to certain animals, such as cats or dogs, and others to chemicals in the air such as hydrocarbon emissions, particularly when in particulate form.
The symptoms can be simple, such as a runny nose, a cough and hay fever or more complex such as hives, eczema and asthma. All of these are caused by the immune system reacting to an invader. There are also foods that cause internal inflammation, such as shellfish and whitefish, eggs and tomatoes. Many of these can be extreme, leading to serious illness and can even be fatal. So what can be done to treat people who are particularly prone to inflammation and allergic reactions?
Omega-3 fatty acids have been found to reduce inflammation, unlike their Omega-6 cousins that appear to increase it. Omega-3 oils contain chemicals known as eicosanoids, of which the prostaglandins are an example. While this might seem paradoxical, since prostaglandins are what set off the whole process, there are many types of these. Prostaglandin E2 is the type that leads to allergic immune reactions, and omega-3 fatty acids reduce the concentration of these in the blood.
Those who eat little fish tend to suffer more from inflammatory conditions such as arthritis and other conditions indicating a lack of control of the immune system. On the other hand, processed foods contain more omega-6 fatty acids that can promote these conditions. The major components of omega-3 oils are alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) and also DHA, docosahexaenoic acid. These are all anti-inflammatories and have been shown to have very positive effects on inflammatory conditions such as rheumatoid arthritis, Crohn’s disease and eczema. Each of these is a different type of inflammatory condition caused by inappropriate immune response.
However, it not just fish oils that can help resolve problems with our immune system. Quercetin is what is known as a flavonoid. It is a strong anti-oxidant and natural anti-histamine that combats histamine release and the swelling associated with the immune response to allergens. It also counters the inflammatory agents of arthritis and so helps to reduce the pain associated with many of these conditions. It appears to work better in conjunction with bromelain, a very powerful anti-inflammatory that also possesses anti-allergen response properties. Bromelain is extracted from pineapple stems.
Another natural product is a resin extract that is obtained from the Boswellia serrata tree. It has powerful anti-inflammatory properties, and has been recommended for the treatment of arthritis (rheumatoid and osteo), Crohn’s disease and has been suggested as a treatment for asthma, though studies are still under way. However, world wide experience is that Boswellia is effective against gout, psoriasis and ulcerative colitis, to name another three totally different inflammatory conditions.
What all of this indicates are two things. First that inflammation, immunity and allergic reactions are connected conditions, and due to either poor control over or an over stimulated immune response to what the body perceives as being abnormal, in the way that hormones and other chemicals that are used to control our immunity detect it to be.
Secondly, there are many natural products that can be used as supplements to treat these effects caused by the immune system, and that their effectiveness has been proven, if not by scientific study, then by generations of traditional application as treatments of the symptoms of the conditions concerned.
However, although many have been proved by scientific study, others have not, and you should always refer to your physician before undergoing any treatment other than that prescribed. Also, there is incontrovertible evidence that the role for supplements in the treatment of inflammation, immunity and allergic reactions are beneficial. Many use nothing else.
September 15, 2007 02:48 PM
For decades, researchers have known about the correlation between polysaccharides and immune system activity. Extensive research has shown that, once successfully absorbed by the bloodstream, these large polysaccharide molecules can potentially support the immune system by increasing the body’s natural production of cytokines—a group of specialized peptide proteins that serve as signaling mechanisms for cells and their target receptors.
Cytokines, such as lymphokines, monokines, interleukins, interferons, and TNF (tumor nectrosis factor) work within the body and encourage the activity of NK cells, T, cells, and B cells. Although specialized polysaccharides are derived from indigestible plant fibers, those same fibers may actually prevent them from entering the bloodstream, thereby minimizing their benefit to the immune system.
More recent scientific advances have determined that, by breaking these long polysaccharides into smaller components called hemicelluloses, these compounds could have a great effect on immune system support. Now Mushroom Glyconutrients was scientifically formulated to support optimal immune system function. It contains RBAC (Rice Bran Arabinoxylan Compound), a specialized type of glyconutrient that is formed when rice bran fibers are broken down using enzymes from select shiitake mushrooms. RBAC has been clinically shown to support the body’s overall immune system.
For added support, NOW Mushroom Glyconutrients also contains a blend of shiitake, maitake, and reishi mushrooms—an excellent source of innate and adaptive immune supporting 1,3 beta-glucans.
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
Air Defense from Now Foods
October 03, 2006 01:36 PM
When it comes to good health, you are constantly on the frontline of defense against an Army of environmental invaders. Exhaust, smoke, airborne toxins and a flurry of other environmental antagonists can make it difficult for even the healthiest of individuals to keep their guard up. Factor this into today’s fast paced, on the go lifestyles, and the need for powerful immune supporting nutrition becomes all to real.
Introducing New Air Defense Immune Booster, from Now Foods. This optimally balanced immune system supplement was scientifically formulated to provide some of the industry’s most trusted cellular safeguards, in one convenient, easy to use formula. One of its most impressive compounds is Paractin – a patented extract of Andrographis Paniculata that has been shown in studies to significantly increase the immune system’s production of interferon gamma (IFNg). Interleukin-s (IL-2), and T-cells. Collectively, these infection-fighting cells make up the body’s primary line of defense against scores of everyday threats.*
Many experts agree that the upcoming flue season could potentially be one of the most devastating and widespread on record. Numerous clinical studies have demonstrated Paractin’s ability to significantly increase cell-mediated immunity (CMI) in response to stresses, such as those commonly encountered during seasonal changes. By stimulating the body’s natural defense mechanisms, Paractin has been shown to increase the body’s production of cytokines – a key factor in healthy immune system response.*
Each serving delivers an impressive 1,000 mg of free radical quenching vitamin C along with an herbal complex of Astragalus, Elderberry, Echinacea, ImmunEnhancer AG (Arabinogalactan, from Larch Tree) and Olive Leaf. Our expert formulators have also included immune-supporting minerals, such as Zinc and Selenium. This advanced, one-of-a-kind formula unites some of the most trusted nutritional compounds available today, and was scientifically formulated to support healthy immune function during seasonal changes and year-around!
New Frontiers in Enzyme Supplementation
February 16, 2006 04:17 PM
New Frontiers in Enzyme Supplementation
By Nick Rana, CN, NOW Quality Assurance
Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.
Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.
The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.
Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.
Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.
The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.
Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).
While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).
The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.
Folic Acid: Strengthening the Immune System in the Elderly
January 09, 2006 09:38 AM
Folic Acid: Strengthening the Immune System in the Elderly
By Greg Arnold, DC, CSCS, December 20, 2005, abstracted from “Dietary folate improves age-related decreases in lymphocyte function” in the January 2006 issue of the Journal of Nutritional Biochemistry Recent research has elucidated health-promoting roles for folic acid beyond that of insuring normal development of the fetus. In addition to helping decrease neural tube defects,1 folic acid can also help treat inflammatory bowel disease 2 improve memory 3 and help decrease an amino acid in the body, homocysteine,4 that increases heart disease risk.5 Now a new study 6 has found another way that folic acid can help us age more gracefully: by helping strengthen our immune system. Recognizing the importance of nutrition in the overall health of the immune system 7 and knowing that certain types of immune system cells, called “T cells”, decrease with age,(8,9) researchers fed 11-month-old and 23-month-old male rats either a control diet or a diet fortified with 35.7 mg per kg of folic acid for three weeks. Researchers found “a significant” increase in immune system strength in the folic acid group, specifically that of increased T cell levels, other immune system proteins called IL-2, IL-4, and anti-cancer proteins called “tumor necrosis factor”. While the study reaffirmed the immune system’s weakening with increasing age, the researchers concluded that “supplementing…with additional folate improves [immune system function] and that dietary folate requirement may be higher in the older population than in the younger population to support immune functions.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com Reference:
Tru-E Bio Complex
December 08, 2005 04:58 PM
Tru-E Bio Complex TMNeil E. Levin, CCN, DANLA 7/27/05
LIKELY USERS: Most Americans are deficient in Vitamin E 8,9,10; People needing superior antioxidant protection3,5,6; People needing cardiovascular or cholesterol support27,30,31; People needing nervous system support7; Those wanting healthier skin6; Diabetics may need additional Vitamin E24 KEY INGREDIENTS: Tocopherols from IP-Preserved, non-GMO Soy; Tocotrienols and tocopherols from non-GMO virgin palm; Tocotrienols from non-GMO annatto seed
MAIN PRODUCT FEATURES: NOW Tru-E Bio ComplexTM is a unique biologically balanced, patent-pending formula designed to provide optimal Vitamin E activity. This product features 100% natural, Non-Genetically Modified sources of all 8 isomers (forms) of the Vitamin E “family” in ratios similar to what is found in a healthy diet. It provides the superior benefits of foodsource Vitamin E versus those obtained from traditional E supplements.
NOW® Tru-E Bio ComplexTM has been carefully blended to supply high levels of the natural gamma and delta “desmethyl” forms of both tocopherols and tocotrienols. This is important because recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues. This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants. This science-based natural Vitamin E supplement is unlike any other and the first to combine all of these benefits in one convenient non-GMO formula! 25-32
Recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues.1-4, 25-32
This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants.1,4-7
Levels of Vitamin E above 100 IU daily are associated with decreased risk of coronary heart disease and certain types of cellular disorders, as well as enhancement of immune function. These vitamin E intakes are considerably above levels obtainable from diet alone. 11,12,13
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:
This is a product that is Patent Pending, based on months of research into optimal forms, potencies and ratios of the 8 isomers of natural Vitamin E. All of the Vitamin E formulas currently on the market use potencies of tocopherols that are very dissimilar to what is found in a healthy diet, with either too low or too high amounts of gamma and alpha tocopherols for a good balance. Some do not even include tocotrienols.
All of the Vitamin E formulas on the market that do contain a mixture of tocopherols and tocotrienols tend to use either 400 IU or 100 IU of alpha tocopherol, some as little as 50-60 IU, combined with varying doses of gamma tocopherol. We have reduced the alpha tocopherol from the standard 400 IU per capsule to 200 IU, allowing more gamma tocopherol in the capsule to follow the typical ratio in a healthy diet. Other brands either cut the alpha tocopherol too low (to keep the gamma tocopherol at a good level) or else cut the gamma and other tocopherols too low (to keep the alpha tocopherol at 400 IU).
Special care was used to maintain a certain ratio of tocopherols and of tocotrienols that is unique and from natural sources. Our formula is also unique in mixing sources of tocotrienols to achieve our desired balance, whereas other formulas include only one source, despite the dissimilarity of the mixture to what is found in a healthy, varied diet.
Other formulas use either Vitamin E derived from genetically engineered soybeans and/or add soybean oil from similar sources as a base. NOW uses expensive non-GMO sources, the first formula to do so, with no soybean oil added. This enhances the quality of our product compared to every other formula on the market.
We use the expensive virgin palm oil rather than the cheap palm distillates because it is un-denatured and contributes additional, valuable oil nutrients such as CoQ10, Squalene and Sterols. Also, much of the clinical research done on tocotrienols was done using virgin palm oil sources 32
Natural Vitamin E is more effective than synthetic Vitamin E.14 - 23
SERVING SIZE & HOW TO TAKE IT: One or two capsules per day, preferably with meal(s). Oils enhance the absorption of Vitamin E. Concentrated fiber supplements may decrease the absorption of Vitamin E, so it is best not to take both at the same meal.
SYNERGISTS: Antioxidants (Alpha Lipoic Acid, Vitamin C Complex, Pine or Grapeseed Extracts, VitaBerry Plus+, CoQ10, etc.), Plant Sterols, Fish Oil, Flaxseed Oil, GliSODin, EGCg Green Tea Extract, Lecithin, Nuts and Seeds
SPECIFIC: Aspirin and blood thinners should not be taken with Vitamin E without physician’s approval. Many other pharmaceutical drugs deplete Vitamin E, adding to the likelihood that a person will be deficient.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
1. Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) g-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714-722.
AHCC® Fact Sheet - from Now Foods.
December 08, 2005 10:20 AM
AHCC® Fact SheetNeil E. Levin, CCN, DANLA 6/30/05
LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity.
KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound)
MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product.
AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system.
This formula is suitable for vegetarians and is offered in Vcaps.
SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach.
COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6),
PRODUCT SPECIFIC: None
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.
DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496.
Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315.
Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.
VitaBerry Plus+ Fact Sheet
December 07, 2005 05:38 PM
VitaBerry Plus+ Fact SheetNeil E. Levin, CCN, DANLA 3/18/05
LIKELY USERS: Antioxidant users who want the best food source formula; People seeking polyphenols or ellagic acid supplements; Those who don’t eat fruit and want some of their benefits
KEY INGREDIENTS: VitaBerry extract, Hi-Active Orange Extract, Pomegranate Extract (420 mg) (400 mg) (100 mg)
MAIN PRODUCT FEATURES: This is a high antioxidant (high ORAC: 2,500 units per serving of oxygen radical absorbing capacity), proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry extract, Grape & Grape seed extract, Raspberry & Raspberry seed extract, Cranberry, Prune, Tart Cherry, Wild Bilberry extract & Strawberry powder. Fortified with Hi-Active Orange Extract (Freeze-dried Orange (Citrus sinensis) powder with minimum of 40% vitamin C) and Pomegranate Extract (80% Polyphenols and 40% Ellagic Acid).
Provides a broad-spectrum antioxidant blend with phytochemicals such as anthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol etc. in a single “0” size vegetarian capsule. There is a synergistic effect of mixing fruit antioxidants that provides antioxidant protection greater than is predicted by measuring each fruit source used in the mix individually.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: There will be some natural variation in color, taste and odor from these fruit sources. A special freeze drying technique preserves the antioxidant value of whole fruits in a concentrated form.
SERVING SIZE & HOW TO TAKE IT: Serving is 2 Vcaps. Take one or more servings per day as an antioxidant supplement. May be taken with food or on an empty stomach (this is food).
COMPLEMENTARY PRODUCTS: All antioxidants.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This information has not been reviewed by the FDA or the company posting it. Information given here may vary from what is given on the product label because this page represents my understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80, 1 p preceding 75. Review. PMID: 14972022
Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci. 2002 Jul 15;22(14):6114-20. PMID: 12122072
Huang D, Ou B, Prior RL. The Chemistry behind Antioxidant Capacity Assays. J Agric Food Chem. 2005 Mar 23;53(6):1841-1856. PMID: 15769103
Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr. 2002 Oct;88(4):389-98. PMID: 12323088
Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem. 2002 Dec 18;50(26):7731-7. PMID: 12475297
Prior RL, Cao G. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J AOAC Int. 2000 Jul-Aug;83(4):950-6. Review. PMID: 10995120
Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med. 1999 Dec;27(11-12):1173-81. Review. PMID: 10641708
Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, Hampsch-Woodill M, Huang D, Ou B, Jacob R. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J Agric Food Chem. 2003 May 21;51(11):3273-9. PMID: 12744654
Proteggente AR, Pannala AS, Paganga G, Van Buren L, Wagner E, Wiseman S, Van De Put F, Dacombe C, Rice-Evans CA. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. Free Radic Res. 2002 Feb;36(2):217-33. PMID: 11999391
Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic property of edible berries. Free Radic Res. 2002 Sep;36(9):1023-31. PMID: 12448828
Sofic E, Rustembegovic A, Kroyer G, Cao G. Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy. J Neural Transm. 2002 May;109(5-6):711-9. PMID: 12111462
Stintzing FC, Stintzing AS, Carle R, Frei B, Wrolstad RE. Color and antioxidant properties of cyanidin-based anthocyanin pigments. J Agric Food Chem. 2002 Oct 9;50(21):6172-81. PMID: 12358498
Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 2004 Jun 16;52(12):4026-37. PMID: 15186133
Allibiotic CF Fact Sheet
December 07, 2005 01:37 PM
Allibiotic CF Fact SheetNeil E. Levin, CCN, DANLA 03/09/05
LIKELY USERS: People seeking support of the immune system and intestinal flora
KEY INGREDIENTS: Allicin (“AlliSure” patented, stabilized allicin from fresh garlic); Olive Leaf Extract (Olea Europaea with 18% minimum Oleuropein content); Elderberry extract, from fruit/berry, 60:1 concentrate (equivalent to 2,500 mg. of fresh berries of Sambucus nigra); Oil of Oregano (wild oregano from Origanum vulgare) ImmunEnhancer AG (trademarked Arabinogalactan from Larch Tree, Larix occidentalis)
MAIN PRODUCT FEATURES: AlliSure is the clinically tested, patented and stable form of allicin. Not allicin potential, but actual allicin. Allicin represents the immune supporting nutrients of raw garlic, and is chemically similar to penicillin, though with different physical properties. AlliSure shares garlic’s abilities to help maintain healthy cholesterol and blood pressure levels, and also has been shown to raise levels of a key T cell to enhance immune system function. Like raw garlic, AlliSure has antimicrobial properties linked to its ability to react with sulfur-containing metabolic enzymes. Allicin is also shown in studies to play a role in controlling blood sugar and abnormal cell growth.
Black Elderberries have strong antioxidant properties, containing flavonoids like anthocyanidins. They have been studied in relation to inhibition of viral replication and of minor inflammations.
Olive Leaf has been used as an antioxidant, cholesterol and blood viscosity regulator, and vasodilator. But its most important use has been as a way to help the body deal with undesirable organisms in the vital respiratory and intestinal areas.
Oil of Oregano (wild oregano, wild marjoram) contains carvacrol and thymol, which are responsible for much of its antimicrobial activities. It also has some anti-inflammatory effects.
Arabinogalactan from Larch tree bark (ImmunEnhancer AG) can help speed the immune system’s response to undesirable organisms and is often compared to Echinacea. It has also been shown to promote the growth of beneficial intestinal bacteria.
ADDITIONAL PRODUCT INFORMATION: Patented and trademarked ingredients enhance quality controls and have clinical research. Rosemary Oil provides antioxidant protection for the capsule contents. Enteric coating protects the capsule from stomach acid to deliver its contents past the stomach. This helps to assure full potency and reduces the possibility of the oils repeating.
SERVING SIZE & HOW TO TAKE IT: One softgel twice daily, preferably with meals. Try one before using the full dose.
COMPLEMENTARY PRODUCTS: Probiotics, Antioxidants, D-Flame
CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Discontinue use if any uncomfortable side effects occur. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. (AlliSure was used in this study.)
Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9. PMID: 10562920
Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997 Oct;41(10):2286-8. PMID: 9333064
Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7. PMID: 8739190
Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. Indian J Med Res. 1991 Jan;93:33-6.
Eilat S, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 1995 Dec;6(12):985-90. PMID: 8723021
Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T. The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens. 2003 Dec;16(12):1053-6. PMID: 14643581
Feldberg RS, Chang SC, Kotik AN, Nadler M, Neuwirth Z, Sundstrom DC, Thompson NH. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8.
Focke M, Feld A, Lichtenthaler K. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett. 1990 Feb 12;261(1):106-8.
Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38(2):245-54. PMID: 11525603
Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol. 2004 Feb;16(2):275-81. PMID: 14734613
Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):144-153. PMID: 11118647
Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44. PMID: 9528659
Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004 Apr;111(4):391-9. PMID: 15056375
Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24. PMID: 15044429
Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 1985 Oct;(5):460-1. PMID: 3001801
Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author's transl)] Jpn J Antibiot. 1975 Aug;28(4):638-42. PMID: 1099271
Yasuo Yamada and Keizô Azuma. Evaluation of the In Vitro Antifungal Activity of Allicin. Antimicrob Agents Chemother. 1977 April; 11(4): 743–749.
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Mascolo N, Autore G, Capasso G, et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987;1:28–31.
Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study. Eur J Clin Nutr. Feb2004;58(2):244-9.
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 104–5.
Yesilada E. Inhibitory Effects of Turkish Folk Remedies on Inflammatory Cytokines: Interleukin-1Alpha, Interleukin-1Beta and Tumor Necrosis Factor Alpha. J Ethnopharmacol. Sept1997;58(1):59-73. Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radical Biol Med 2000;29:51–60.
Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Alt Compl Med 1995;1:361–9.
OLIVE LEAF EXTRACT:
American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.
Bennani-Kabchi N, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie. Nov1999;54(6):717-23.
Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4. Gonzalez M, et al. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58:513-515. Visoli F, et al. Oleuropein protects low density lipoprotein from oxidation. Life Sciences. 1994;55:1965-71. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:557.
Petroni A, et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.Thromb Res. Apr1995;78(2):151-60. Pieroni A, et al. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie. Oct1996;51(10):765-8. Zarzuelo A, et al. Vasodilator effect of olive leaf. Planta Med. Oct1991;57(5):417-9. OREGANO OIL (OIL OF OREGANO, WILD OREGANO, WILD MARJORAM):
Dorman HJ, et al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. Feb2000;88(2):308-16. Force M, et al. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. May2000;14(3):213-4.
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985–90.
Kelm MA, Nair MG, Strasburg GM. Antioxidant and Cyclooxygenase Inhibitory Phenolic Compounds from Ocimum sanctum Linn. Phytomedicine. Mar2000;7(1):7-13. Lamaison JL, et al. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm Acta Helv. 1991;66(7):185-8.
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Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67–72. ImmunEnhancer AG (Larch tree Arabinogalactan)
Corado J, et al. Impairment of Natural Killer (NK) Cytotoxic Activity in Hepatitis C Virus (HCV) Infection. Exp Immunol. 1997;109:451-457. Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. PMID: 12725568
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Astragalus Fact Sheet
December 07, 2005 01:15 PM
Astragalus Fact SheetNeil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg)
MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides.
ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!).
SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants.
CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
CLA Extreme Fact Sheet
December 07, 2005 12:59 PM
CLA Extreme Fact Sheet Neil E. Levin, CCN, DANLA 01/31/05
LIKELY USERS: People wanting to control body fat; People wanting to increase their body’s lean mass (muscle tissue); People wanting an oil that helps to reduce pro-inflammatory body chemicals; Those wanting to prevent undesirable cellular changes through diet KEY INGREDIENT (S): CLA from safflower oil, L-Carnitine amino acid, Guarana Seed extract (20% naturally occurring caffeine), Green Tea extract (40% polyphenols), Chromium Picolinate
MAIN PRODUCT FEATURES: Conjugated Linoleic Acid (CLA) is a derivative of linoleic acid, an essential fatty acid. The softgel is formulated with CLA (derived from safflower oil), Green Tea extract (polyphenols), Guarana extract (caffeine), L-Carnitine, and Chromium (III) Picolinate for synergistic effects of reducing body fat and increasing lean muscle mass.
OTHER IMPORTANT ISSUES: One study, titled "Efficacy and Safety of One-Year Supplementation with Conjugated linoleic Acid in Moderate Overweight," found that compared to placebo, CLA-supplemented subjects had Body Fat Mass index scores averaging 9% lower than the placebo group and had Lean Body Mass results showing lean muscle mass averaging 2% more than the placebo group. Analyses of blood tests showed no side effects over this one-year period. CLA plus Guarana reportedly reduces the size and number of fat cells in another report. CLA may also reduce insulin resistance and prevent undesirable cellular changes.
AMOUNT and HOW TO USE: One to five capsules a day, preferably with meals.
COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, Vitamin E, other Antioxidants
CAUTIONS: CLA may reduce insulin resistance, so people on blood sugar medications may not need as much of their drugs. Use with caution to avoid an overdose of your blood sugar medication when using this oil. Please notify your physician about your supplement use if you are using any drugs!
Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 79(6):1118–1125 (2004).
Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-1 0,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 80(6):1626–1633 (2004).
Aminot-Gilchrist DV, Anderson HDI. Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1159S–1163S Suppl. S (2004).
Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui YZ, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127(3):777–791 (2004).
Bergamo P, Luongo D, Rossi M. Conjugated linoleic acid - Mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. Cell Physiol. Biochem. 14(1–2):57–64 (2004).
Bouthegourd JC, Martin JC, Gripois D, Roseau S, Tome D, Even PC. Fat-depleted CLA-treated mice enter torpor after a short period of fasting. Appetite 42(1):91–98 (2004).
Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK. Conjugated linoleic acid induces human adipocyte delipidation - Autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279(25):26735–26747 (2004).
Cheng WL, Lii CK, Chen HW, Lin TH, Liu KL. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappa B pathway. J. Agric. Food Chem. 52(1):71–78 (2004).
Choi JS, Jung MH, Park HS, Song JY. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20(11–12):1008–1017 (2004).
Cortes HN. CLA and body composition: Research shows conjugated linoleic acid can help maintain a healthy balance between lean muscle and body fat. Agro Food Industry Hi Tech 15(2):49–51 (2004).
Dauchy RT, Dauchy EM, Sauer LA, Blask DE, Davidson LK, Krause JA, Lynch DT. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. Cancer Lett. 209(1):7–15 (2004).
Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med. Sci. Sport Exercise 36(5):814–820 (2004).
Field CJ, Schley PD. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Am. J. Clin. Nutr. 79(6):1190S-1198S Suppl. S (2004).
Hirao A, Yamasaki M, Chujo H, Koyanagi N, Kanouchi H, Yasuda S, Matsuo A, Nishida E, Rikimaru T, Tsujita E, Shimada M, Maehara Y, Tachibana H, Yamada K. Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats. J. Nutr. Sci. Vitaminol. 50(1):9–12 (2004).
Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 323(2):679–684 (2004).
Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions. Lipids 39(7):611–616 (2004).
Lamarche B, Desroches S. Metabolic syndrome and effects of conjugated linoleic acid in obesity and lipoprotein disorders: the Quebec experience. Am. J. Clin. Nutr. 79(6):1149S–1152S Suppl. S (2004).
Malpuech-Brugere C, Verboeket-van de Venne WPHG, Mensink RP, Arnal MA, Morio B, Brandolini M, Saebo A, Lassel TS, Chardigny JM, Sebedio JL, Beaufrere B. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Res. 12(4):591–598 (2004).
McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SB, Trevisan M, Freudenheim JL. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB study). Cancer Epidemiol. Biomarkers Prevent. 13(9):1480–1484 (2004).
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PepZin GI™ helps relieve occasional discomfort.
September 20, 2005 05:40 PM
PepZin GI™ helps relieve occasional discomfort.* CLINICAL TRIALS
In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-carnosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-Lcarnosine group. Of the group, 92% of the participants were rated as “moderately improved” or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.3
In another study, 28 patients with gastric discomfort were given a zinc-L-carnosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be “significantly improved” was 68.4%. After eight weeks, the “significantly improved” number was 68.8%. Over 60% of these patients remained in the “significantly improved” category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-carnosine compound beyond the time it is taken.4
Maintains a healthy GI environment.*
The mineral zinc in PepZin GI™ is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds,and maintenance of carbohydrate and lipid metabolism.2
PepZin GI™ may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-carnosine co m pound may have effects on certain strains of harmful bacteria and, therefore, may be able to help maintain a GI environment that is favorable to health.1 By supporting the bacterial balance in the stomach, PepZin GI™ can help maintain a healthy mucosal lining.
Supports the health of gastric cells.*
PepZin GI™ has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-carnosine, or a combination of zinc-L-carnosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-carnosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress and alcohol induced damage.5
Additional research further confirms the gastro-protective effects of PepZin GI™. In another rat study, stomach lesions were induced by administration of the chemical monochloramine, a known pro-oxidant (producer of free radicals). One of the groups of rats was fed the zinc-Lcarnosine compound prior to being exposed to monochloramine. The researchers found that the size of the lesions in the group pre-treated with zinc-L-carnosine was significantly less than the lesions in the control group. The authors concluded that the zinc compound exerted a beneficial protective effect against monochloramine-induced stomach lesions.6
The zinc-L-carnosine in PepZin GI™ has also been shown to slow the development of aspirin induced stomach damage in rats. The researchers measurably detected lower levels of TNF-alpha in rats given zinc-L-carnosine as compared to the control rats. TNF-alpha is an inflammatory cytokine that is known to be released in response to gastric damage.7 These results may suggest a role for PepZin GI™ in protecting gastric cells by occasionally reducing the levels of certain cytokines in minor inflammation of the stomach.
1. Kuwayama H, et al. Polaprezinc. Nippon Rinsho 2002 Feb; 60 Suppl 2:717-720. 2.Matsukura T,Tanaka H. Applicability of zinc complex of l-carnosine for medical use. Biochemistry (Moscow) 2000;65(7):817-823. 3.Miyoshi A, et al. Clinical evaluation of Z-103 on gastric ulcer - a multicenter double-blind comparative study with cetraxate hydrochloride. Jpn PharmTher 1992;20(1):199-223. 4.Misawa T, et al. Clinical study of Z-103 - clinical effects on gastric ulcer and influence on endocrine function. Jpn PharmTher 1992; 20(1):245-254. 5. Hiraishi H, et al. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacl Ther 1999;13:261-269. 6. Kato S, Nishiwaki H, et al. Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate. Dig Dis Sci 1997;42(10):2156-2163. 7.Naito Y, et al. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci 2001;46(4):845-851.