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	Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?	Darrell Miller	12/7/23
	A species of hawthorn has been found to control abnormally highblood sugar levels	Darrell Miller	5/2/19
	CoQ10 can help to stop nonalcoholic fatty liver disease, studyreveals	Darrell Miller	4/29/19
	High-Fiber Diet Found Beneficial To Cancer Patients	Darrell Miller	4/22/19
	Coconut oil studied for its potential to reverse Alzheimer's	Darrell Miller	4/22/19
	Antioxidant power: Blueberry extract found to improve health outcomes for women receiving radiation for cervical cancer, reducing the damaging effects of the therapy	Darrell Miller	1/6/18
	Is Fluoride Bad for You? It’s Not Just in the Water	Darrell Miller	10/19/17
	There is a cure for your child's lack of growth	Darrell Miller	8/17/17
	Nutritionist Reveals Five Prebiotic Foods That Can Feed Your Gut	Darrell Miller	8/15/17
	On Health: Do carbs make you fat?	Darrell Miller	3/13/17
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	How much protein you need a day	Darrell Miller	11/6/16
	What Is Thymoquinone Found In Black Seed Oil?	Darrell Miller	9/28/15
	What Is GABA And Why Is It Important For The Brain	Darrell Miller	12/21/13
	Melatonin spray: The Perfect Remedy for Insomnia	Darrell Miller	5/10/12
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Date: December 07, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body.

While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption.

GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age.

The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels.

In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body.

This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form.

But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them.

So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing!

Liver Health

When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ.

Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds.

During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances?

But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker!

The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning.

So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being!

Alcohol Intoxication

Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells.

To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes.

The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group.

The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver.

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels.

Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy.

In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management.

Beautiful Skin

By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions.

Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores.

Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects.

Skin Lightening

Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract.

The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women.

In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH.

Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin.

The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities.

In summary, the administration of glutathione, whether oral, buccal, or topical, has shown promising results in skin lightening and the improvement of complexion. Studies have demonstrated that glutathione not only enhances skin brightness but also reduces hyperpigmentation, wrinkles, and minimizes pores. Moreover, its effects have been evident in as little as two weeks, with a sustained impact over longer periods. These benefits were observed across a range of different skin types and ethnicities. However, it is important to highlight that these findings are based on specific populations, and more research needs to be conducted to confirm the consistency of these effects across a broader spectrum of skin types and ethnicities. The studies have also confirmed that the usage of glutathione is well-tolerated with no serious adverse effects reported.

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Date: May 02, 2019 02:45 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A species of hawthorn has been found to control abnormally highblood sugar levels

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Date: April 29, 2019 05:04 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: CoQ10 can help to stop nonalcoholic fatty liver disease, studyreveals

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Date: April 22, 2019 04:35 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: High-Fiber Diet Found Beneficial To Cancer Patients

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Date: April 22, 2019 04:31 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Coconut oil studied for its potential to reverse Alzheimer's

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Date: January 06, 2018 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Antioxidant power: Blueberry extract found to improve health outcomes for women receiving radiation for cervical cancer, reducing the damaging effects of the therapy

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Date: October 19, 2017 10:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is Fluoride Bad for You? It’s Not Just in the Water

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Date: August 17, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: There is a cure for your child's lack of growth

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Date: August 15, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Nutritionist Reveals Five Prebiotic Foods That Can Feed Your Gut

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Date: March 13, 2017 01:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: On Health: Do carbs make you fat?

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Date: February 26, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Testosterone Therapy May Have Benefits, But Risks Too

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Date: February 09, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Four foods you need to stop eating before bed if you're trying to lose weight

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Date: January 19, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A New Marijuana To Relieve Pain Without The High

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Date: November 29, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Microbes in your gut influence age-related macular degeneration

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Date: November 06, 2016 10:09 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: How much protein you need a day

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Date: September 28, 2015 08:53 PM
Author: Darrell Miller
Subject: What Is Thymoquinone Found In Black Seed Oil?

The black seed oil is obtained from the seeds of the Nigella Sativa plant. The black seeds, also known as the black cumin, were used by the ancient Egyptians because of their ability to cure a variety of health conditions such as toothaches, headaches. It was also used as a dietary supplement. Additionally, the black seed oil is effective in ensuring a stable immune system as well as combating diseases that affect the immune system. The medicinal power of this oil emanates from its active ingredient, thymoquinone.

Thymoquinone is an active compound that contains anti-inflammatory, anti-cancerous, and antioxidant properties. Research indicates that thymoquinone can thwart the cancerous cells in the colon, pancreases, and prostate. Because of the healing properties of this compound, black seed oil, therefore, remains useful as far as human health is concerned.

Some of its benefits includes:

• Treating cancer

The black seed oil has been used for a long time to treat cancer. According to the research from three Chinese researchers and four Arabian scientists, black seed oil contains the right anti-cancer properties. They noted that the black seed oil was used as a traditional medicine for many years. The active compound, thymoquinone, contained in the black seed oil is effective against many other diseases such diabetes, kidney, asthma diseases.

• Fever and flu

Taking a teaspoon of the black seed oil can help cure fever or flu. It causes the body to sweat for it to recover from the illness.

• Curing insomnia

Research indicates that black seed oil can help a person sleep well if suffering from insomnia. One teaspoon of the oil put in a warm drink before sleeping helps to eradicate the problem.

• Curing arthritis

Studies show that the black seed oil responds positively to the treatment of Rheumatoid arthritis. Further studies indicate that this oil helps reduce inflammation in the joints and the stiffness that occur in the morning.

• Curing asthma and cough

Black seed oil is an anti-bacterial and anti-inflammatory, and it is ideal for treating coughs and also addressing asthma symptoms. It achieves this by relaxing the bronchiole tube muscles.

• Radiation treatment

According to researchers from Turkey, black seed oil is potentially helpful to people receiving radiation treatment for cancer.

The thymoquinone compound in black seed oil makes this oil essential to the health of human beings. Consumption of the black seed oil will keep you off from most cancer infection and diseases.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3224)

Date: December 21, 2013 01:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is GABA And Why Is It Important For The Brain

What is GABA

The human brains need various supplements to make it work better. One such supplement is the gamma aminobutyric acid, abbreviated as GABA. It is the second most important neurotransmitter for the brain. The neurotransmitters allow synapses that transfer information to gray matter in human. This amino acid gives human an inhibiting experience thus making one calm. This makes it possible for one to have a feeling of well being and tranquility.

GABA on Human Body

GABA is useful in the human body because it acts as neurotransmitters. This means you are protected from nerve impulses. This neurotransmitter cools the brain. Research has shown that it helps to increase alpha wave production. This is related to the feeling of relaxation we have in brains.

For the brain to work, it must receive impulses smoothly. Human who lack GABA get affected by receiving impulses in spurts. Spurt makes the brain get arrhythmia. This contributes your emotional well being.

For the brain to work well, it has to be free from various conditions. Some of these conditions come because GABA is not present. Insufficiency leads to one showing symptoms of anxiety, irritability, and constant headaches, getting hypertension, palpitations, epilepsy, low sex drives and heart disorders.

GABA on Insomnia

With enough GABA, it is known to prevent the feeling of insomnia. This comes when neurons firing decreases to make one have a restful sleep. The calming effect helps an individual’s brain to have elevated moods which is an important part for reducing blood pressure. To enable an individual have more concentrations when working, they need to have increased levels of GABA.

Ideally, the brain changes as we become old. With enough concentration of GABA in bodies, we actually slow the aging effects. This helps to trigger and stimulate pituitary glands that give human beings their growing hormone, the HGH. Aging causes HGH to slow down thus leading to degenerative diseases and wrinkles.

References:

1. //www.wisegeek.com/what-is-gaba.htm
2. //bethanycarder.com/archives/238

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Date: May 10, 2012 11:02 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Melatonin spray: The Perfect Remedy for Insomnia

Melatonin Spray

Are you experiencing difficulty in sleeping or feel tired in the morning every day? Probably you are suffering from insomnia. Getting enough sleep is an aspect that you cannot just choose to overlook. receiving the desired amount of sleep helps your body in a plethora of ways. Most people even get overstressed due to lack of sleep, an aspect that can even adversely affect their quality of life in the long term and short term both. Sleep helps to boost the immune system, repair damaged cells, boost your thinking capacity and also generally helps the body to deal with the daily stresses in life.

If at all you are experiencing difficulty in breathing, you most definitely have visited your local healthcare provider recently. If they prescribed some medication for you, do they really seem to work?

You might have gotten prescription of NyQuil and Tylenol. If these options do not work, there is only one way out that case, and that is the use of melatonin spray. Melatonin is produced by the pineal gland that is located at the center of the brain. As experts state, this gland is normally inactive during the day but later during the night, it secretes melatonin into the blood stream. Melatonin is normally produced between nine at night till sunrise. The amount of melatonin produced by the body tends to reduce with age. Children produce more melatonin than adults. This explains why most cases of sleeping disorders are reported in the elderly rather than kids.

Melatonin is sold as a sleeping aid in many different forms. You most likely know about the capsules. Most of these pills do not work for many people unless they are taken for some time so that the system can get used to. Due to the limitations and lack of effectiveness witnessed in the use of capsules, companies manufacturing synthetic melatonin have now started producing melatonin spray. The melatonin spray has a higher absorption rate as compared to pills and thus more effective.

So how does melatonin spray work?

Well, this sleeping support spray helps melatonin to distribute and get absorbed evenly into the system without necessarily having to interfere with other minerals, supplements and food vitamins. If at all you are part of the population that is experiencing difficulty in sleeping, do not waste much of your time investing in less effective over the counter pills such as Tylenol PM. You can do your body a very big favor by adopting the use of melatonin spray.

This kind of spray works effectively to ensure that you regain back your sleep. It is also safer to use as compared to other sleeping aids. At least with this option, you do not have to keep worrying about side effects meaning that this is a much safer alternative. Even though the benefits you would gain from the use of melatonin spray are numerous, the safety of this alternative is still in question in various parts of the globe. It is therefore important for you to consult your doctor before you can start using this sleep aid. Working with your doctor is much recommended if at all you suffer from certain health conditions.

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Date: March 10, 2012 12:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Cordyceps Mushroom good for?

Cordycep mushrooms

Cordycep mushrooms have been receiving a lot of hype lately, as they are said to have many compounds that can benefit ones health. Cordycep mushrooms have been used for 1500 years in ancient Chinese history, and was proven to benefit a variety of factors. However, it seems as if people are having a tough time when it comes to looking for them, as they are known for being in natural habitats. Cordyceps itself is a type of fungus, and it includes over 400 kinds of described species. Cordyceps are abundant in tropical areas, as they tend to thrive better in humidity and high temperature. Cordyceps have also had an extensive history of being a medicinal fungi. Cordyceps are not really known in the Western world, as scientists have not been able to study it properly yet. However, since China has been studying the fungus for some time now, some of this fungus' secrets were already unfolded. The main reason to why Cordyceps have received so much attention is that the History Channel stated that if someone finds an ounce of Cordyceps, you will be given 900 dollars.

The Benefits To Taking A Supplement Of Cordycep.

One benefit to taking a supplement of cordycep is that it dilates the airways of your lungs, allowing more oxygen to your lungs. Cordyceps are also known for fighting the means of womens infertility. It also enhances mens sexual performance and fuction by stimulating the sex hormones. Cordyceps helps in building muscle and even improve ones physical performance as well. It also has the capability to reduce the effects of fatigue, and has anti-aging properties as well. These help in strengthening the liver and kidney, as it improves the natural flow of your blood. They help strengthen and even enhance your immune system because it has the capability to increase and improve a huge amount of natural killer cells.

Where Can You Find Cordyceps In Nature Habitats?

Cordyceps can be found in a huge array of areas such as Australia, Asia, Europe, North America, China, and Russia. However, they tend to grow in the South areas of tropical places. The best places to look for cordyceps would have to be in the areas where ants climb the moment before they pass away. Those areas are tree branches and the bottom of tree leaves. They can also be found in tropical forests as well. The fruiting body of a Cordycep sort of has a grass-like appearance, making it easy for them to be spotted. They also kind of look like worms, and though they are technically mushrooms, in wild areas, they can grow on plants, insects, caterpillars, and a variety of other fungus' as well.

Cordyceps can be found in a huge array of areas, so you must learn and know exactly what they look like to actually find a couple ounces. Cordyceps are said to be worth a fortune, and its value has even increased throughout the years. Even if it's tough to find cordyceps, at least the reward that you are given is decent.

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Date: May 24, 2011 11:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Why Are Fresh Sprouts Like Alfalfa, Barley, and Wheat So Good for Your Health?

Sprouts For A Healthier Body!

Fresh sprouts are among the healthiest of all foods. They are rich in enzymes that are not found in the human body. These enzymes help facilitate better absorption of vitamins and minerals. Alfalfa, barley, and wheat are examples of plants that are capable of sprouting when soaked in water. They are best consumed fresh when they still contain all of their nutrients. They make excellent ingredients to salads and sandwiches that can complement any meal. They can be processed in juicing machines, too.

You might have heard of the nutritional value of grasses and legumes. Wheatgrass is becoming increasingly popular nowadays as they have been receiving a lot of good press lately. Wheatgrass and barley grass has in fact earned the moniker superfoods. Alfalfa, on the other hand, is a legume recently rediscovered for its phytochemical content. It has been a forage crop for centuries, but human consumptions have steadily increased in the past few years. Apart from the fact that wheat, barley, alfalfa can be consumed as fresh sprouts, they also bring similar benefits to human health.

Restore Normal pH Levels

Proponents of the alkaline diet believe that the body is in a constant cycle of alkalinity and acidity, which is partially dependent on the foods that we eat. The body raises alkalinity with every acidic by-products of digestion to maintain pH balance. That being said, a significant fraction of the human diet is acid-forming, tipping the balance in the process. Fresh sprouts are often linked to the alkaline diet, which aims to restore pH balance of the body.

Have High Nutrient Content

Alfalfa, barley grass, and wheatgrass are very good sources of vitamins and minerals. They are particularly rich in dietary minerals that help the body function at its best. Plus, they contain amino acids, essential fatty acids, dietary fiber, and carbohydrates in amounts adequate to complement any other foods that make up a healthy diet. One of the very noticeable improvements after months of consuming fresh sprouts is the increase in red blood cell count.

Cleanse the Body of Toxins

Aside from the fact that fresh sprouts are effective free radical scavengers, they also improve the natural antioxidant defense of the human body. Wheat, barley, and alfalfa are reliable sources of potassium, magnesium, manganese, and selenium, all of which are involved in chemical reactions that lead to effective removal of toxic by-products of metabolism. Fresh sprouts are capable of neutralizing reactive oxygen species such as free radicals. Furthermore, they facilitate the excretion of toxins.

Promote Heart Health

Fresh sprouts are particularly good for the cardiovascular system. They maintain the health of red blood cells. They limit the releases of low-density lipoproteins into the blood, thus lowering bad cholesterol and free fatty acids. They help control high blood pressure and promote normal blood flow. They maintain healthy levels of blood sugar by improving glucose metabolism. And, of course, their antioxidant profile enables them to protect the heart and arterial walls from lipid peroxidation.

Have you had your sprouts today?

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Date: July 01, 2009 12:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Honey from bee's

Bees make honey out of the nectar that they sip from flower blossoms. A long and tedious process is necessary to transform nectar into the thick, golden substance that we call honey. Like each product that is produced by the honeybee, care and a number of steps are essential in order to create this beehive food, with honey being no exception. This sweet, nutritious edible substance is a viscous fluid that is exclusively created by the honeybee. Even the most sophisticated modern techniques have failed to synthetically manufacture honey. Like royal jelly, propolis, and bee pollen, honey is only available from Mother Nature. It is a precious and coveted substance that has fascinated and pleased cultures throughout time.

The ancient Greeks called honey one of nature’s most precious gifts, while the Assyrians, Chinese, and Romans routinely prescribed it for its medicinal value. Numerous biblical references refer to the “Honeycomb” and the “Land of Milk and Honey,” as well as the “Enlightenment” that comes from eating honey. Hippocrates recorded that a honey drink cures phlegm and calms down a cough. He was one of the first known advocates for using Honey and Vinegar for fevers and other ailments. All of ancient cultures believed that the use of honey each and every day would insure health and longevity. All kinds of wines and foods were routinely mixed with honey, causing them to be viewed by all peoples as a treasure which the gods provided for health.

Of all the ancient cultures, Egyptians prized honey enough to use it as a form of money. Hieroglyphics often refer to honey as the universal healer and jars of honey were routinely placed in tombs of the dead. Because of its superior preservative properties, honey used to be an integral part of the formula that was used in the mummification process. Throughout all of history, honey has been used to treat open wounds and fight infection. Unfortunately, the advent of refined sugar caused honey to take a back seat to other more popular sweeteners. Thankfully, today honey is experiencing resurgence, as it was once an often overlooked beehive food that is full of nutritive and medicinal value.

When a bee lands on a flower, it sucks a tiny amount of nectar to its honey sac. It is within this sac that the transformation of nectar to honey begins. The nectar is mixed with acid secretions to eventually form the coveted honey that we consume. Substantial amounts of nectar are necessary to produce significant amounts of honey, making flying the distance of up to three miles necessary to obtain the amounts of nectar that is needed to fill the sac. Once the sac is full, the honeybee returns to the hive, where a receiving bee takes the nectar and continues the process, changing, enriching, and concentrating the nectar. Following this, the receiving bee drops the mixture into the empty cells of the honeycomb.

In order to produce a single pound of honey, bees must provide the hive with over 70,000 loads of nectar. A healthy beehive can produce about 300 pounds of honey each season. The health benefits of honey have now been captured by manufactures like Premier one and Montana big sky. Natural honey is available in liquid form at your local or internet health food store. Look for name brands to ensure quality and purity of the product you purchase.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Honey is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

Fine Honey Products from Premier one are available at VitaNet ®, LLC Health Food Stores.

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Date: October 16, 2008 03:42 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Dangers Of Over The Counter Drugs

Parents have recently been hit with shocking information about the potential dangers to their children. First it was lead contamination that came from toys that were manufactured by some of our most trusted companies. Next, it was super antibiotic resistant bugs that may lurk in day care centers and schools. The latest information is of greatest concern. Every study performed in the recent years has found that children’s cough and cold remedies are ineffective and may, in fact, be potentially dangerous. The American Academy of Pediatrics recommended against the use of multi-symptom, over-the-counter, cold medicines in children under the age of three unless the parents are advised by a physician.

Many parents have depended on these medicines for years to help with runny noses, coughs, and sleep disruptions. However, our kids are not the first generation to suffer from frequent respiratory troubles. Herbal and dietary remedies have been the first line of defense for centuries, with Elderberry being rich in flavonoids, essential oils, vitamin C and organic acids. It reduces mucous secretions, helps ease breathing, and soothes an irritated nose and throat.

If your child frequently deals with a runny nose, earache, and sinus infection, he or she may have hidden food intolerances. One doctor states that there are various ways that you can recognize hidden childhood allergies. A classic symptom is the “allergic salute”, which the child demonstrates when he is constantly rubbing his or her hand across the end of a runny nose.

Food allergies are difficult to determine with standard allergy testing, but by avoiding common allergic provoking foods like dairy, wheat, corn, and tree nuts, often brings relief to the child. Changing the family diet is the best way to eliminate offending foods. Replace all forms of sugar and other refined carbohydrates, as they slow down bowel transit time and increase exposure to toxic bowel contents. Natural sweeteners, which can be found in most health food stores, can be used instead. Since dairy products top the list of provoking foods, they should be replaced as much as possible with other beverages. Inspect labels carefully to determine if they contain casein, which is a milk protein that often causes problems. A liquid calcium supplement is a good idea to give your children if they are not receiving dairy products.

Allergic children are often prone to digestive problems, which is a condition referred to as intestinal dysbiosis. Antibiotic use disturbs the microflora in the gut by killing helpful bacteria. Psychological stress can also impact microflora, which poses the question of whether or not stress is having a negative impact on our children’s health. Studies in which some children were placed in a stress relieving program showed that treated groups of children increased their levels of secretary IgA, which gives them a greater ability to resist colds.

Allergic children also have disturbed bowel function, making them constipated, frequently pass gas, be bloated, and have foul smelling hard stools. A low fiber diet is one cause of constipation, but an imbalance in microflora in the gut is another reason, which causes toxins to enter circulation. Supplementing with Bifidobacteria and other helpful probiotics can restore normal gut function, alleviate allergic symptoms, restore immune competence, and reduce allied bowel problems. Supplementing with fiber can also support proper elimination of toxins in children as well as adults. Acidophilus, fiber, and herbal cold aids can be found at your local health food store.

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Vitanet ®, LLC

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Date: September 26, 2008 03:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lutein 20mg (FloraGlo)

Maintains Healthy Visual Function*

It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the first four weeks of the study, plasma levels increased five-fold from pre-supplement measures, and then remained at this level for the duration of the study. It was also shown that, due to increased deposition of lutein in optical tissues, macular pigment density increased by an average of 5.3% at the 4-week mark, and continued to increase until the duration of the study.1

A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids might play a protective role in supporting the maintenance of healthy vision.2

The Age-Related Eye Disease Study (AREDS) was a landmark study of the effects of diet and antioxidant supplementation on eye health. The study enrolled over 3500 subjects aged 55 to 80 years who were followed for approximately 6 years. Among the data collected in this multi-faceted study was a self-administered Food Frequency Questionnaire (FFQ). The AREDS Report No. 22 examined the data from the FFQs and determined that, of the nutrients evaluated, only lutein and zeaxanthin were directly related to maintaining eye health with statistical significance3. These findings corroborated similar results of an earlier multi-center study published in the Journal of the American Medical Association that also found that those with a higher intake of lutein and zeaxanthin maintained healthier eye function.4 These promising results have spurred the design of a second major clinical trial (AREDS2), which is currently enrolling participants to study the impact of supplemental xanthophylls (FloraGLO® Lutein and zeaxanthin) and other nutrients on age-related eye health.5

In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg FloraGLO® lutein, 10 mg FloraGLO® lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the FloraGLO® lutein and FloraGLO® lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.6 These results demonstrate FloraGLO® lutein’s beneficial effect on maintaining healthy visual function.

Newly published research has demonstrated that lutein and zeaxanthin supplementation may enhance visual performance under glare conditions. Forty healthy subjects took daily doses of 10 mg FloraGLO® Lutein plus 2 mg zeaxanthin for six months. They were evaluated for changes in macular pigment, glare disability and photostress recovery at the onset of the study, and at 1, 2, 4 and six months. After six months, subjects experienced an average increase in macular pigment optical density (MPOD) of 39% compared to baseline, and all but two participants experienced some increase in MPOD. This increase in MPOD was also directly related to measured improvements in visual performance after exposure to bright light, as well as photostress recovery.7 This study suggests another way in which lutein and zeaxanthin can help support optimal visual function in healthy individuals.

Potent Antioxidant Protection*

Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.8

More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol9 demonstrating its potential as a high-powered antioxidant.

A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental models of a number of body systems.10

Supports Healthy Skin*

A recent randomized, double blind, placebo-controlled study has demonstrated the positive effects of oral and topical administration of lutein on skin health parameters (surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation). Forty female subjects were divided into four treatment groups. Treatment options included oral administration of 5 mg of FloraGLO® Lutein twice daily or placebo and topical administration of 50 ppm FloraGLO® Lutein twice daily or placebo. Each treatment group received either an active oral treatment with a placebo topical treatment, a placebo oral treatment with an active topical treatment, both active treatments, or both placebo treatments. Statistically significant improvements were seen in all five parameters tested in all treatment groups compared to the group receiving only placebos. The greatest overall improvements were seen in the group receiving both active oral and topical treatments, while lesser but still significant improvement was seen in both the active oral only and the active topical only groups. Additionally, oral administration of lutein conferred superior photoprotective activity (as measured by skin surface redness after exposure to ultraviolet light) and prevention of lipid peroxidation (as indicated by levels of malondialdehyde in skin lipids after exposure to ultraviolet light) than either topical lutein or placebo.11

Diverse Cinical Benefits*

Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.12

Suggested Adult Use: One softgel daily with food, or as directed by a health care professional.

Does Not Contain: milk, egg, wheat, sugar, sweeteners, starch, salt, or preservatives.

Scientific References

1. Berendschot TT, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Opthalmol Vis Sci. 2000 Oct; 41(11): 3322-6.

2. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7.

3. Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9): 1225-32.

4. Seddon JM, et al. Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration. JAMA. 1994 Nov; 272(18):1413-1420.

5. www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=120. Clinical Studies Database. Age-Related Eye Disease Study 2 (AREDS2). Last Updated 2/28/2008. Viewed 5/15/2008.

6. Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230.

7. Stringham JM and Hammond BR. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008 Feb; 85(2):82-8.

8. “Lutein and Zeaxanthin”. PDR Health. www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/lut_0164.shtml

9. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32.

10. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S.

11. Palombo P, et al. Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol. 2007; 20: 199-210.

12. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.

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Date: July 31, 2008 02:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Feverfew Leaves

Feverfew is most commonly used in the treatment and prevention of migraine headaches. Migraines are extremely common and can be very difficult to treat. Other methods of relieving pain have been explored because, for many migraine sufferers, conventional treatments have not been successful. Feverfew is one of the most successful forms of alternative treatments that have been found for treating migraines. Many studies have been conducted which have validated the already existing knowledge of many herbalists: feverfew is a great tool for helping to prevent migraines in many cases.

Although feverfew had long been used for treating headaches, its popularity declined with the advent of modern medicine. The herb has resurged into medical interest after the wife of a doctor who worked for the British National Coal Board had been suffering from migraines and was told by a coal miner to trey chewing on two feverfew leaves a day. After trying the herb, the woman noticed improvement, with fewer and less severe migraines. Her husband then urged a migraine specialist in London, Dr. E. Stewart Johnson, to test feverfew, with the results of several studies now showing it to be effective.

Dr. Johnson agreed to try the herb because he had many patients who had been suffering from migraine pain for years and had yet to find a successful treatment. Originally, he tried the herbal remedy on only ten of his patients. The results of this trial were so promising that it led to a study of another 270 of his patients, with seventy percent reporting that they received significant improvement when receiving feverfew for their headache pain.

Following this, a group of researchers in the City of London Migraine Clinic were led by Dr. Johnson to conduct a study, which was reported in the British Medical Journal, investigating seventeen patients who had already been using feverfew for at least three months. All were asked to discontinue use of their original method of treating with feverfew. Eight patients were given a capsule of feverfew, while the other nine were given a placebo.

Those that were given a placebo had an increase in frequency and severity of headaches, nausea, and vomiting, while those that were given feverfew capsules had no increase in frequency or severity of their migraines. This research has led to the belief that feverfew is advantageous in the prevention of migraines. Many other studies have been done to further test the effects of feverfew. It has been concluded that feverfew treatment is effective and there were always definite improvements in the group that used feverfew. Additionally, there were no serious side-effects that appeared to exist.

Feverfew seems to have similar properties as NSAIDs such as aspirin and ibuprofen. Also, the parthenolide that is found in feverfew is the main inhibitor for the formation of compounds that promote inflammation. Parthenolide reduces the secretory activity of blood platelets and white blood cells. This is important because migraines are thought to be associated with abnormal platelet behavior, as they are responsible for the release of serotonin, which constricts blood vessels and leads to migraine pain.

Feverfew is now recognized by the British and Canadian governments as a migraine treatment and is often prescribed by doctors. Many physicians and pharmacists have recent began to take more interest in the use of herbal remedies, especially since patients are beginning to become more interested in natural methods of healing.

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Date: May 30, 2008 02:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bacopa Extract

You're ready to leave the house, you're already running late and you can't remember where you put the keys. You try retracing your steps, check all of your coat pockets and start to panic. You can't remember where you put them or where you last saw them. Does this sound familiar? Do you have trouble focusing clearly? Our thinking process slows as we age. It is as if a cloud lingers over our brains, making it impossible to think clearly.

Improve Your Mind with Bacopa Extract

There is help for people who can't learn or think as fast as they once could. An all-natural product, bacopa extract, has been used for thousands of years as a "brain tonic" in India. It has been used to enhance memory, learning and concentration. This aquatic plant has strong antioxidant powers. It helps people retain new information by stimulating the brain's neurotransmitters.

Bacopa extract can be used for:

* Relieving anxiety
* Lessening depression
* Improving memory and learning
* Activating the brain
* Neutralizing free radicals
* Relieving stress
* Lessening the effects of ADHD in children
* Helping students learn
* Increasing mental alertness
* Producing a calming effect on the brain
* Learning new information quickly
* Retaining information longer
* Improving concentration and focus
* Treating Alzheimer's disease

It also has antispasmodic and anti-allergic properties.

Clinical Study Proves Benefits of Bacopa Extract

A study reported in the August 2002 issue of Neuropsychopharmocolgy, "Chronic Effects of Brahmi (Bacopa) on Human Memory," stated positive results. The study found that "Brahmi decreased the rate of forgetting of newly acquired information."

This means you can learn faster and think more clearly when taking a bacopa extract. Consider, for example, a situation in which you are meeting people for the first time and being introduced to them by name. Will you be able to remember any of their names when you see them across the room in 10 minutes? How about if you run into them a few weeks later?

What if you couldn't remember their name, or worse, called them by the wrong name? That doesn't send a very good first impression. Or maybe you have been on the receiving end of this and have been repeatedly called the wrong name by someone. You know how irritating it can be. Bacopa extract can help in this type of situation. Taken daily over an extended period of time, you will see a difference in the amount of information you can retain. You won't have to struggle so much to recall where you left your keys or the name of the person you just met.

Studies have shown that bacopa extract is effective for mental acuity. It helps by smoothing neurotransmitters and relaxing the brain. It has no known side effects and is deemed safe for children, as well.

Pair Bacopa Extract with a Healthy Lifestyle for Best Results

As with any natural supplement, bacopa will not improve your mental health unless it is accompanies by healthy lifestyle choices. Make sure you get the proper rest your body needs, daily exercise and good nutrition. Furthermore, it is important to exercise your brain. Find ways to challenge your mental alertness on a daily basis. Combine this with a daily dose of bacopa extract and you will see improvement in the clarity of your thinking.

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Vitanet ®, LLC

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Date: January 21, 2008 11:59 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Why Should I Take A Liquid Vitamin Supplement?

There are more and more liquid products appearing on store shelves, but most people are unaware that they all fall into one of seven categories of people who should be using them. Below are the seven categories of people that can really benefit from liquid nutrition.

Type #1 consists of those people who have age-related poor digestion or a loss of appetite. As we get older, our ability to digest foods decreases. When liquids are manufactured correctly, they are much easier to digest and absorb for almost every person. Nutritional deficiencies go right along with poor digestion and loss of appetite. Therefore, a small capful of a multiple vitamins and mineral liquid offers a good amount of nutritional benefit to persons who have impaired digestion and loss of appetite. Also, a collagen-based liquid supplement can work to help build healthy tissues and keep lean muscle weight on people. Since collagen is the foremost protein in the body and makes up all our tissues, which include our hair, eyes, and nails, its role in our health is essential.

Type #2 people are usually too busy to eat and are very low in fiber. A lot of people are too busy to eat right, so liquid nutrition helps to meet the challenge. 9 out of 10 Americans do not get the daily recommended amount of fiber and most don’t even get half the recommended amount. Newly available liquid fiber has made it more likely and easy for those Americans lacking fiber to achieve the recommended daily amount. The liquid can be taken “as is” from the bottle or added to any food or beverage.

Type #3 is those people who have difficulty swallowing which includes both children and adults. A liquid nutritional multiple vitamin and mineral provides a complete mix of vitamins, minerals, antioxidants, and phytonutrients in one single serving.

Type #4 people are those who are undergoing chemotherapy or radiotherapy. Liquid supplements are often the only way for these people to receive adequate nutrition as chemotherapy can diminish gastric function.

Type #5 consists of those people who are undergoing surgery, chronic disease, and recovery from illness. As some medical conditions can increase your nutritional needs and make it harder for you to meet those requirements from foods alone, liquid supplements, which are highly concentrated and typically supply many nutrients in a few ounces, are perfect for these individuals. With liquid supplements, these individuals are able to properly nourish their bodies to make up for what they are missing in food.

Type #6 is those people who are seeking nutrition insurance. Even though some people are consuming the minimum recommended dietary allowance for some nutrients, it does not mean that they are actually receiving enough for optimal health. Some recommended amounts are actually set too low for what we now know is needed for the average healthy individual. For these people, liquid supplements provide nutritional insurance and are easy to take and digest.

Type #7 people are those who are living on a budget. Liquid supplements actually save consumers money as compared to the number of different supplements you would need to purchase to equal what you would get in one capful of a super-concentrated liquid supplement. People who care about their health and take vitamin supplements can now enjoy their pills in liquid form.

Whether you fall under one of these categories or not, taking a liquid vitamin supplement can improve health and help you meat your bodies nutritional needs at a less expensive price than conventional multiple vitamin supplements. Visit your local health food store for brands and availability.

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Date: January 18, 2008 10:54 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Join The Age Specific Probiotic Revolution For Better Health

Probiotics are good or friendly bacteria that may just be the most important supplement of all. Probiotics may help boost your immunity, heal disease, and according to recent research, help prevents cancer. All of the above especially applies to both babies and vulnerable older adults. Along with helping people to maintain healthy populations of beneficial bacteria, probiotics have many other health benefits. One that has recently become known is the ability to protect against colon cancer.

A recent study in Ireland found that probiotics, which are live bacteria that can benefit health, may also be just as important as vegetables, legumes, whole grains, and regular exercise in our strategies to lower the risk of cancer. This study was performed on eighty patients who had had either colon cancer tumors or polyps recently removed. Each patient received either a probiotic or a placebo. Included in the probiotic was Lactobacillus rhamnosus and a Bifidobacteria that was combined with other probiotics. These formulas which contain live probiotics and prebiotics are known as synbiotics. After three months of use, the balance of colon bacteria in those receiving the symbiotic formula had changed to having more lactobacilli and Bifidobacteria and less of the bacteria that is linked with increasing cancer risk, as compared to those patients who received placebos.

Additionally, those patients who received synbiotics showed a decrease in DNA damage in the lining of the colon along with a decreased growth and reproduction of colon cells. Also, neither of the groups reported any adverse effects of the synbiotics. These findings were also consistent with those of earlier studies, concluding that “bad” bacteria can produce substances that promote the development of colon cancer. Probiotics have also been shown to decrease abnormal colon cell development and DNA damage in animals.

However, these findings are not yet enough for the FDA to allow the claims that probiotics work against colon cancer, but rather simply state that they support colon health. These studies certainly suggest that the right beneficial strains in the right amounts of probiotics in your gut are a great amount better for you than too much of the bad bacteria.

Many people take a lifetime approach to probiotics, believing that they are appropriate for people of all ages, from babies to children to adults. Probiotics have an immunomodulatory effect at any age by stimulating and boosting the immune system. Even for infants, probiotics are critical. It has been shown that mothers who take a probiotic blend during pregnancy have babies who are less prone to eczema and other allergic conditions.

Additionally, the advent of new methods has made it possible to characterize the gut microbiota changes as we age, and in health and disease. Because of this, products that target specific issues and ages have been produced which can work with each individual’s needs. The two key bacteria helping advanced adults are Lactobacillus rhamnosus and Bifidobacteria, as they provide the additional bacterial strains that are associated with the older adult’s needs. Additionally, newborns and babies do not need the same composition as adults. Instead, products for babies include B. infantis, B. bifidum, and B. breve. The greatest thing about probiotics is that you can’t overdose. Probiotics are always quite safe and very effective.

When buying a probiotic supplement, look to your local health food store to find the freshest name brand probiotic because not all probiotics are made the same.

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Boost Health At Vitanet®, LLC

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Date: January 17, 2008 03:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pine Bark Extract Boosts Nitric Oxide Production

A recent study has found that Pycnogenol, which is an antioxidant plant extract from the bark of the French maritime pine tree, helps individuals by enhancing the production of nitric oxide (NO), which in turn leads to an increase in blood flow and oxygen supply to muscles. Nitric oxide is a key cardiovascular chemical that is produced by the body. It increases blood flow which allows more nutrients and oxygen to be delivered to the muscles. This helps muscles to cope with increased physical activity. The study also suggests that taking Pycnogenol provides more NO in response to neurotransmitters which allows for better expansion of arteries, which can then carry more blood. This process meets the enhanced oxygen demand of muscles and helps to avoid anaerobic metabolism. The results of this study also lead researchers to believe that Pycnogenol can be a natural alternative therapy in diseases involving oxidative stress.

The study was held at the Hiroshima University Graduate School of Bio-medical Sciences in Japan. Each day for two weeks, healthy, young men were given either 180 mg of Pycnogenol or a placebo. In order to identify Pycnogenol's effect on the release of nitric oxide, patients were infused with an inhibitor of L-arginine, which restricts arteries from expanding in response to the neurotransmitter acytelcholine. After two weeks of supplementation, the results revealed that blood flow had increased by forty two percent. Additionally, the group receiving a placebo did not show a significant blood flow increase at all. NO causes the muscle surrounding the arteries to relax, resulting in an increase in the diameter of the blood vessel, while acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster. When the subjects being tested had taken Pycnogenol, the arteries relaxed and blood flow increased by Fourty two percent, as compared to the placebo group.

Although more research is warranted, this breakthrough is especially encouraging to athletes since Pycnogenol seems to allow people to move faster when they are exercising. It does this by satisfying the enhanced muscle oxygen demand and also increases the blood flow to the active muscles. People who are performing heavy physical activity experience the release of acetylcholine by nerves to arteries that are supplying the active muscles. This acetylcholine makes them expand, while the whole process requires that there is an enhanced production of nitric oxide.

A great variety of studies about Pycnogenol and sports nutrition have been conducted over the past years. The most recent one occurred a year ago. In this study, Pycnogenol was found to improve blood circulation even in extended aerobic muscle activity. Pycnogenol also enhanced sports endurance be alleviating the cramping and muscular pain that occurs in the majority of athletes. To sum it up, Pycnogenol is not only effective for enhancing and prolonging the performance of muscles during support, but it also supports muscle adaptation to a higher workload and allows the body to recover from physical faster.

When shopping for a good pycnogenol supplement, look for a standardized extract that guarantees that each capsule or tablet contains a specific amount of active ingredients per serving, otherwise you might be purchasing something that is ineffective.

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Pine Bark Extract available at Vitanet®, LLC

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Date: January 17, 2008 02:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Better Vision Through Bilberries

"Eat your carrots! They're good for your eyes!" Isn't this what your mother always told you? Isn't that what you learned as a kid? Well, how about re-writing that phrase? How about making it into the phrase: "Eat your bilberries!"

What is a bilberry? A bilberry is a shrub just over a foot tall. The bilberry plant possesses a fruit, the cousin of the blueberry, that is indigenous to Northern Europe. These fruits contain bioflavonoids, an antioxidant with a variety of health benefits. A thousand years ago bilberries were used to relieve diarrhea and kidney stones. Today, the bilberry sees use as a treatment and preventive measure in a variety of situations. Some of the benefits seen in the modern age include possible prevention of heart disease and macular degeneration. In fact, bilberries may help strengthen the eyes when used by people regularly who aren't suffering from any ocular conditions.

The active ingredients in the fruit are tannins, which are an astringent and anti-inflammatory. The bilberry also contains anthocyanidins, which are compounds that strengthen capillaries and improve the flow of blood through the circulatory system. These anthocyanidins also increase the body’s production of rhodopsin, which is a pigment responsible for enhanced night vision and increased adaptability to changes in light by the eye. In fact, a jam made from the fruit was used by British Royal Air Force pilots in World War II who often reported that it improved their night vision, a crucial aid in an ace pilot's career.

The anthocyanidins in the bilberry fruit are a bioflavonoid. A bioflavonoid is a substance found in plants which helps strengthen the walls of capillaries. Many bioflavonoids support human health in various ways, such as naringenin which aids in cancer prevention. Others may be useful in treating liver conditions such as cirrhosis. The variety of bioflavonoid uses is a field that is still being developed.

Bioflavonoids have an extensive history. From the previously mentioned uses for bilberries to research after World War II into the connection between bioflavonoids and vitamin C, these biologically active wonder substances are an exciting branch of health supplements. They are available in various forms for your convenience.

Bilberry extract comes in a capsule form, usually meant to be taken three times daily. The manufacturer will have instructions in case of varying dosages. Bilberry extract contains the most potent dose of bioflavonoid that the bilberry has to offer. It is this potency that makes the extract the best choice for maximum ocular benefit. But it is not the only choice, in case you are looking for another way to enjoy receiving its unique health bonuses.

Bilberry tea is also made from the dried berries or the leaves of the plant. The berries are also eaten fresh or made into jam, just like the aforementioned British pilots did. The taste of a bilberry is very similar to that of a blueberry: slightly tart, slightly sweet. It has traditionally been baked in pies and it a special treat with syrup and ginger ice cream. That's a taste worthy of the fruit's pedigree!

In the world of health supplements, the unique properties and advantages this fruit, particularly bilberry extract, make it a worthy addition to anyone's daily regimen. Maybe there's a toddler in the house who won't eat his carrots. He will get similar eye benefits by eating the sweet fruit of the bilberry plant. Perhaps a tasty dessert that packs its own reward would be a welcome addition to the dinner table. The possibilities are limitless. Try some of the fruit or extract and invest in a healthier future.

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Buy Bilberry at Vitanet®, LLC

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Date: November 04, 2007 03:19 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Digestive Enzymes To Improve Wellness For Kids

It is very safe to say that most people experience some type of digestive difficulty, as digestive disturbances are very common, especially for those who do not practice healthy eating. The numerous advertisements for antacids and acid blockers clearly identify the degree of this problem. But, what about our children? It has been proven that kids are suffering from digestive problems more than ever before due to unhealthy eating habits and nutritionally deficient diets that are high in saturated fats and processed sugars and carbohydrates. The food that is served in school cafeterias often contains too much fried food and not enough fresh produce. Additionally, parents have to constantly fight a losing battle against advertisements for junk food. Many children follow in the footsteps of their parents, picking up the same bad eating habits, which frequently leads to poor digestion and health problems. Overeating, eating too fast, or not chewing food well hinders digestive capability leading to symptoms such as gas, heartburn, bloating, burping, bad breath, diarrhea, constipation, and general discomfort or fatigue after meals. Although these symptoms are common, they should not be considered normal as they are distress signals sent by our body telling us that the digestive process is not going smoothly and we are not receiving the full nutritional benefit of the food we eat. If digestion is not efficient or complete, inflammation may develop, which causes “leaky gut syndrome,” leading to various allergic reactions.

The brain is especially susceptible to protein fragments, which come from the incomplete digestion of grain gluten and dairy casein. Researchers believe that these fragments, which are called exorphins, are the main factors in the cognitive symptoms and abnormal behaviors of those kids with ADHD and autism. A recent study on thirty-six autistic children found that a majority of these children had digestive disorders including esophageal reflux and inflammation, gastritis, duodenitis and low carbohydrate digestive enzyme levels. Some doctors believe that seventy-five percent of the children that they treat have major deficiencies of pancreatic enzymes.

Enzymes are often called the spark of life or the missing link in nutrition because no plant or animal can exist without them. Digestive enzymes are protein catalysts which break down food so the body can absorb nutrients. Therefore, enzyme supplementation can be extremely helpful, especially when it is done in conjunction with dietary changes. And, yes, kids can take enzymes supplements, too. In children with digestive symptoms, enzyme supplements help to establish proper weight because better assimilation of nutrients helps growth and repair while still supporting a healthy metabolism. Digestive enzymes come in mild-potency enzyme formula which covers all of the food groups for children. Children should take a powder which is safest so there are no caps to swallow and chock on and powdered enzymes allow children to get their digestive enzymes through one scoop which can be added to your child’s favorite juice. Some formulas add potassium carbonate, this form of potassium adds a fun fizz to whatever beverage is used, but is not recommended in milk or water. Look for a powdered supplement that is sweetened with xylitol, a safe and natural sugar substitute which supports tooth and gum health. Since more children than ever suffer from the consequences of incomplete digestion, digestive enzymes are a safe and effective way to support digestion and assimilation of important nutrients into your child’s diet in an enjoyable way.

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Get Digestive Enzymes for Children

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Date: October 22, 2007 10:02 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Tongkat Ali: The Natural Viagra?

Tongkat Ali is also known as Longjack, and is a well known aphrodisiac in South East Asia, the root of which has been found effective both as an aphrodisiac and in treating certain sexual problems including failure to achieve an erection. What Viagra does in the west, Longjack does in the east, only cheaper.

The tree is also called Pasak Bumi, and had originally been used for many years as a treatment for malaria, the side effects being accepted but not understood as originating from the malaria medication. Some though that the malaria itself perhaps caused them, and was a long time before the effect of tongkat ali on the testosterone levels in the body was understood.

The name literally means Ali’s walking stick, and is named after the long roots from which it is extracted. The tree itself is about ten metres high, and grows beneath the canopy of the Indonesian rainforests. However, due to a heavy demand for the product, the older trees are increasingly more difficult to find, and most of the herbal preparation is extracted from younger trees. The tree itself is not easy to cultivate outside its natural environment, and is very slow growing.

Unlike many herbal remedies used in Asia, the effects of Tongkat Ali on the libido have been supported by scientific medical evidence, and it has been demonstrated to support the availability of unbound testosterone and to support hormonal balance in general. It had been used for many years to promote sexual desire and sexual ability before the medical evidence was obtained to provide scientific support to what was already known by the indigenous population: that it was effective in improving sexual ability, stamina, and endurance and to reduce mental fatigue in general.

Although it was originally used as a treatment for malaria, Longjack increases the natural production of testosterone in the body and hence improving the male sex drive and also that of women. It is a little known fact that women, too, need testosterone for their sexual impulses. However, it is probably more important from a physiological point of view that testosterone is essential to women in that it increases the metabolic rate and accelerates the burning and elimination of fats, and the production of red blood cells and the development of muscle tissue.

As the production of testosterone drops off with age, generally starting after about thirty years, bodybuilders find it increasingly more difficult to maintain a good body shape and muscle shape. They are interested in anything that could feasible maintain or even increase the production of testosterone by the body, and Tongkat Ali does this. To them, the increase in their libido, or sex drive, is a bonus that they will not refuse to take advantage of!

Eurycoma longifolia, the scientific name for the tree, increases the amount of adenosine triphosphate (ATP) in the body. ATP, along with its cousin adenosine diphosphate (ADP), is responsible for the availability of energy for use by the body. It is normally created from ADP and glucose, and an increased availability in the blood can reduce the fatigue caused by its consumption through vigorous exercise. However, if too much ATP is available, the subject can suffer from insomnia and restlessness since there is too much ATP in the body.

The function of the ATP is to provide available energy that can be used by the muscles in exercise. When energy is used up the ATP is converted to ADP, which needs more glucose to reform the ATP. If there is excess ATP, it is like a charged battery within the body, and we become restless until the energy available is used up.

Another benefit of this amazing substance is that it helps the body to increase its own production of sex hormones, rather than simply provide them for it. People who suffer from sexual dysfunction conditions tend to be provided with HRT (Hormone Replacement Therapy) from their physicians or doctors which involve the introduction of testosterone intravenously. The result of this is that your body recognizes that it has a sufficient supply of testosterone and so stops making it for itself. Eventually your body just stops testosterone production, and relies on the artificial supply it has got used to receiving. Longjack treatment, however, does not provide a supply of testosterone, but stimulates your body to produce its own, which is better for it in the long run.

You should, however, be made aware of the possible side effects or testosterone administration which are insomnia, anxiety and a possible reduction in your immune functions. There are also other possible side effects if you suffer from diabetes, or heart liver or kidney disease, and you should always refer to your doctor before commencing its use. If you start off your treatment with small doses and check out the side effects at each stage, then you will be able to safely find out if these side effects relate to you. If not, then you are all set as long as you obey the advice of your physician.

Another natural product that is recommended as an aphrodisiac is Horny Goat Weed, but when used in combination with Tongkat Ali it appears to have a synergistic effect. Horny Goat Weed is also called Fairy Wings and a number of other alternatives names, and is not one but about 60 different flowering plants found in southern China. It works by increasing the nitric oxide concentration in the body that helps to relax the smooth muscles.

By itself Horny Goat Weed is an effective aphrodisiac, but the combination of its effect in relaxing the penile muscles and the increased testosterone levels promoted by Longjack is extremely powerful, and much more effective in resolve sexual problems in men that either of them alone.

For this reason tongkat ali is frequently sold in combination with horny goat weed. Although not unusual, it is not common to find natural herbs that have such a profound effect on the libido and whose effect is backed up by scientific evidence. Tongkat ali is one of those, and although it is still currently mainly used in Asia, demand for it in the west is rising.

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Boost Libido at Vitanet, LLC ®

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Date: May 28, 2007 11:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Paulings Vindication

Decades later, in January 2007, the FDA finally acknowledged the legitimacy of Pauling’s approach by approving the Cancer Treatment Center of America’s investigation of high-dose intravenous vitamin C and its effects on cancer patients. Meanwhile, Korean researchers undertaking a similar investigation reported in February 2007 that cancer patients receiving mega-dose intravenous vitamin C were found to show greater physical, emotional and cognitive function, while reporting less fatigue, nausea, vomiting, pain and appetite loss.

Intravenous mega-dose vitamin C is entirely different league from supplementation—but many studies suggest that vitamin C supplements may help prevent cancer.

In the Nurse’s Health Study, premenopausal women with a family history of breast cancer who consumed an average of 205mg of vitamin C every day (well above the RDA) experienced a 63% lower risk of breast cancer than women who consumed an average of 70mg a day. A prospective study that tracked 870 men over 25 years found that those who consumed over 83mg of vitamin C daily had a 64% reduction in lung cancer. University of California researchers tracking 12,000 adults for an average of ten years found that those with the highest vitamin C intake had the lowest death rates for all cancers. Finally, an analysis of 90 separate studies found that vitamin C and vitamin C rich foods offered significant protective effects against various forms of cancer.

Vitamin C is already a supplement superstar—but, as it turns out, we may just be beginning to understand its far-reaching health benefits. –Patrick Dougherty

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Date: April 10, 2007 11:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: D-Ribose Powder Benefits!

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Date: March 08, 2007 12:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Revita

Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.

Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.

To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.

Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.

Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.

Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.

In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."

In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:

• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.

• 78.9% of subjects showed an increased mean value of hair diameter.

• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."

Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.

Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:

• Total Number of Hairs: Significantly Increased

• Total Number of Terminal Hairs: Significantly Greater

• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher

• Hair Follicle Activation: Intensive

In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.

Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.

Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.

The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.

Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.

Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.

Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.

Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.

Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.

If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.

Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.

The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.

After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.

Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.

MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.

The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.

MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.

Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.

The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.

According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.

The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.

Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.

Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.

The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.

Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.

Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.

Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.

L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.

The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.

Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.

In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.

Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.

Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.

Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.

Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.

After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.

This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.

Q. Is Revita safe ?

A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.

Q: Can I use hair sprays, mousses, gels, etc.?

A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.

Q: Can I have my hair colored or permed while using Revita ?

A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.

Q: What is SLS/SLES free ?

A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.

Q: Can I blow dry my hair after using Revita ?

A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.

Q: Who is a candidate for Revita ?

A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.

Q: What type of results should I expect with Revita ?

A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.

Q. Does Revita have any systemic side effects ?

A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.

Q. Does Revita work for women?

A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.

Q. I am using other topical treatments. Can I use Revita at the same time ?

A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.

Q. Do I need to use Revita for a long time ?

A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.

Q: Is stress a factor in hair loss?

A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1480)

Date: February 25, 2007 12:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Neurological Health and CoQ10

Between 1946 and 1965, 78 million Americans were born, creating the largest number of children in U.S. history. This Baby Boom generation has greatly influenced the makeup of American society and undoubtedly w ill continue to do so. Thanks to good nutrition and health care, Baby Boomers are aging well and have an excellent life expectancy. For the first time in history, we have more people turning 60 every day, and record numbers of adults reaching their seventh decade. As a result, neurological diseases associated with aging, such as Parkinson’s disease, are becoming major health care concerns. The good news is CoQ10 has applications for neurological diseases, in addition to its better known use for cardiovascular diseases.

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone (existing everywhere there is human life). CoQ10 is vital to the production of adenosine triphosphate (ATP). ATP is the energy-rich compound used for all energy-requiring processes in the body.

Q. Isn’t CoQ10 a supplement for heart health?

A. Yes, it is. Because the heart requires lots of ATP to meet its high energy needs, CoQ10’s function in heart health is well understood. Numerous clinical studies have demonstrated that when individuals with heart disease take CoQ10, their symptoms improve, sometimes quite dramatically. Supplemental CoQ10 improves the heart’s pumping ability, improves blood circulation, increases tolerance to exercise, and improves the heart’s muscle tone. CoQ10 also is a powerful antioxidant and protects heart tissue from free-radical damage.

Q. How does CoQ10 affect brain health?

A. CoQ10 works in the brain the same way it works elsewhere in the body: it’s essential to ATP production. Nearly all human cells contain tiny structures called mitochondria. Mitochondria are referred to as cell powerhouses because they produce cellular energy. Depending on what each cell’s job is. There can be several thousand mitochondria in one cell. If a cell needs a lot of energy, it will have more mitochondria. This explains why heart cells contain so many mitochondria; the continual pumping of blood requires continual ATP production.

The brain also requires huge amounts of uninterrupted energy to regulate, integrate, and coordinate ongoing nervous system transmissions. To meet this need, ATP production within the mitochondria of brain cells is vital. Since CoQ10 exerts such a powerful influence on heart cells in ATP production, it was a natural progression for scientists to wonder how it affects brain cells. Brain and nervous system research led to the conclusion that the same intracellular principles apply. CoQ10 is produced in the body to assist in ATP production. Without it, ATP cannot be produced.

The most important discovery regarding CoQ10 and the brain is that CoQ10, when formulated with certain ingredients, can cross the blood-brain barrier and enter the brain’s mitochondria. If large amounts of CoQ10 can get into the brain cell’s mitochondria, its ability to make ATP is greatly enhanced.

Q. What is the blood-brain barrier and why is it important?

A. The blood-brain barrier is a unique anatomical structure. The cells that make up the blood vessels that provide blood to the brain are extremely close together. This greatly restricts what can leave the bloodstream and enter the brain. While the blood-brain barrier protects the brain and spinal cord from potentially toxic substances, it also can be a significant obstacle to therapy of central nervous system disorders. Only substances with certain solubilities or those that have a transport system can cross the blood-brain barrier to a significant degree.

Obtaining optimal absorption of CoQ10 is difficult. The CoQ10 molecule is large and inflexible. The easiest and least expensive way to increase absorption levels is with the use of harsh solvents such as propylene glycol. However, at higher doses, these types of chemicals are considered dangerous (neurotoxic) to the person with a serious neurodegenerative disease. It is more difficult, as well as more expensive (considering raw materials, research, and proper manufacturing methods) to promote absorption with less harmful alternatives. However, reputable companies ensure that their products are safe for all their customers. Look for CoQ10 products formulated with vitamin E and other safe ingredients such as Micosolle.

Nearly all CoQ10 supplements enter the bloodstream. But, only CoQ10 supplements with special formulations have been scientifically shown to enter the mitochondria and cross the blood-brain barrier.

Q. If CoQ10 is made in the body, why take supplements?

A. While CoQ10 is synthesized in the body, these levels may be insufficient to meet the body’s requirements. Researchers have discovered CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. They also have determined some medications significantly reduce CoQ10 levels in the body.

Although CoQ10 exists in some dietary sources, it may not be realistic to obtain CoQ10 through food alone. For example, it would take approximately 3 pounds of sardines, 7 pounds of beef, or 8 pounds of peanuts to equal 100 mg of supplemental CoQ10.

Q. How does CoQ10 help people with Parkinson’s disease?

A. CoQ10 seems to have several beneficial actions in the illness. Researchers have looked at mitochondria in brain cells and determined people with Parkinson’s disease have reduced activity of Complex I in the electron transport chain. Recent research has proposed the reduced activity of Complex I interferes with the brain-signaling chemical dopamine. Stored and newly synthesized dopamine is depleted. The dopamine depletion causes nerve cell degeneration.

A recent clinical study involved 80 patients with Parkinson’s disease (both men and women). The researchers first evaluated all the participants to establish scores for basic motor skills (measuring the ability to control physical movements such as walking), mental status (whether the person was depressed or experiencing memory loss) and the activities of daily living (whether the person was experiencing difficulty with handwriting, dressing themselves, using utensils such as knives and forks, and so on). This scale is known as the Unified Parkinson’s Disease Rating Scale (UPDRS). This process is known as establishing “baseline values,” that is, the condition of the patient before receiving any treatment.

Participants were divided into 4 groups. Each group received either 300 mg, 600 mg, or 1200 mg of the special form of CoQ10, or a placebo. The researchers observed the participants for 16 months.

The results of the study showed that all the participants who received CoQ10 had smaller declines in function compared to the placebo group, but the smallest decline was experienced by the group taking the highest amount of the special form of CoQ10.

The most significant results were noted specifically in the activities of daily living scores by the people taking 1200 mg of CoQ10 daily. These people retained better ability to feed and dress themselves, speak, walk, and bathe or shower by themselves. They maintained greater independence for a longer time. Parkinson’s disease, as with other neurodegenerative diseases, robs the sufferer of their ability to control the movements of their own body and care for themselves. Supplementation with CoQ10, while not a cure, is the first intervention that showed a slowing in the progressive deterioration of the function associated with this disease.

Q. What were the results of clinical research on Huntington’s Disease?

A. A randomized, double-blind, placebo controlled study respected type of study, was conducted at the University of Rochester. All of the 347 Huntington’s disease (HD) patients were experiencing some HD symptoms, but were still in the early stages of the disease. The patients (who did not know which drug they were receiving) were randomly assigned to four different treatment groups: 25 percent received Remacemide, 25 percent received CoQ10, 25 percent received both, and 25 percent received a placebo, or sugar pill. The researchers, who also did not know which patients got which drug, watched and recorded their progress for two and one-half years. Remacemide is a new drug made by Astra Seneca that blocks the neurotransmitter glutamate in the brain, that has long been suspected of contributing to the death of brain cells in Huntington’s disease.

Unfortunately, in the CARE-HD study, Remacemide had no effect on the progression of the disease in patients in the early stages. However, the individuals who received 600 mg of CoQ10 per day experienced some slowing of the disease progression. They were able to manage daily activities, such as meal preparation, housekeeping tasks, and personal care longer than those not on CoQ10. They were also able to focus their attention better and were less depressed and irritable. The portion of the studied patients receiving 600 mg of CoQ10 per day experienced a 15 percent decline in the progression of HD. According to the researchers conducting the study, a 15 percent decline in the progression of HD would roughly translate into approximately one more year of independence for patients. This is the very first study from more than a dozen Huntington’s disease patient trails that showed any modification of the course of the illness.

Of note, the effects of the CoQ10 had not abated at the end of the research study. That is, the benefit of using CoQ10, 600 mg per day, was still increasing; this suggests that the longer a patient supplements with CoQ10, the greater the decline in the progression of HD. The next phase of the CARE-HD research will test a higher dose of CoQ10 (1200 mg or more per day), with more patients (over 1000), for a longer period of time (approximately 5 years). This study should improve our understanding of the optimal dose and the total achievable decline in the progression of HD. The CoQ10 product used in the CARE-HD study was designated an Orphan Drug by the FDA. The product utilizes a proprietary, patent-pending delivery mechanism, which is proven to be safe and tolerable at high doses for people suffering from neurodegenerative diseases, substantially improving brain tissue levels of CoQ10.

Q. What other diseases could benefit from CoQ10 supplementation?

A. Studies show CoQ10 levels are greatly reduced in Alzheimer’s patients. Mitochondrial abnormalities also are noted; however, research has yet to determine how or why this occurs. Some scientists believe damage to mitochondria is an early feature of the disease. Free-radical damage also is a feature of Alzheimer’s.

In a study of 27 Alzheimer’s patients, subjects were given 60 mg of CoQ10, 150 mg of iron, and 180 mg of vitamin B6 daily. Each patient’s mitochondria activity was effectively activated. All patients continued to experience gradual decline. However, researchers believed that with this combination, the progression was much slower and allowed the patients to experience 1 to 2 years of extended good health.

ALS (also known as Lou Gehrig’s disease) is a progressive, fatal, neurological disease. It occurs when the nerve cells in the brain that control voluntary movement gradually degenerate. Investigation of CoQ10 in individuals with ALS is just beginning. Researchers at the Eleanor and Lou Gehrig ALS Center at Columbia University recently conducted a small clinical pilot trial of CoQ10 in ALS. The study was an open label study, which meant that everyone enrolled received CoQ10, 400 mg three times per day. Of the 16 patients originally enrolled, nine patients completed the study. Six of these nine patients experienced some benefits. The patients declined from 0 – 25 percent in functional scores, 6 percent in strength, and 10 percent in breathing ability. These scores reflect a positive trend compared to the 50 percent decline that is seen in the natural history of ALS over the same period of time (5 to 9 months). Citing the need to conduct more studies of the effectiveness of CoQ10 for people with ALS is rapidly and efficiently as possible to get answers to patients and clinicians, another clinical trial is currently underway at the Gehrig ALS Center. This is a pilot study to determine if CoQ10 has short-term effects on motor nerves in the brain using magnetic resonance spectroscopy (MRS). The researchers are going to try to “see” if CoQ10 can change the chemical sin the brain’s upper motor nerves of people with ALS, an important next step of the investigation.

Q. Can taking CoQ10 prevent neurodegenerative disease?

A. To date, there have been no studies or research examining whether CoQ10 can prevent these diseases.

Alzheimer’s disease prevention is being clinically investigated. Researchers have determined that people who take certain anti-inflammatory medications seem less likely to develop the illness. A large, multi-centered trial is studying this connection.

Q. How much CoQ10 should I take?

A. Depending on your family history of neurological disease and your disease experience, studies show benefits at doses of 100 to 200 mg of CoQ10 daily. Some studies used doses of up to 1,200 mg per day.

CoQ10’s safety has been evaluated. To date, no toxicities have been reported. Mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.

Q. What should I look for in a CoQ10 supplement?

A. Use products which have a strong clinical research track record, supported by product-specific research from reputable institutions, and have been proven to be safe, tolerable and effective in treatment of neurodegenerative diseases. The CoQ10 product you choose should be proven to: be absorbed, enter the blood stream, cross the blood brain barrier and increase mitochondrial levels of CoQ10. If the product you are considering does not have evidence to support these points, keep looking. Once you have found a candidate, examine the product’s safety and efficacy record for neurodegenerative diseases- if the product has not been proven to be safe and effective, keep looking. Good products exist; however, caveat emptor.

Conclusion

CoQ10 supplementation for people with neurodegenerative diseases is supported by contemporary clinical research. CoQ10 is certainly not the only answer to the complex issues of management and treatment of these types of diseases. However, research indicates that it is a bigger piece of the puzzle than physicians and scientists ever imagined. As we continue to study this naturally occurring compound, we are finding more and more benefits to the body.

All CoQ10 is not created equal. For safety and overall effectiveness, use a CoQ10 product that is supported by product-specific research from reputable institution, which is proven to be safe, tolerable and effective at high doses; deviating from this set of criteria may do more harm than good for people with these serious illnesses. Choose clinically tested products from a well-respected company and increase the potential to achieve and maintain brain and neurological health.

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Buy Coenzyme Q10 (COQ10) at Vitanet

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1459)

Date: January 26, 2007 06:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mushrooms are good for the Immune System

Medicinal Mushrooms Grown on Purple Kculli Corn Yield Life Changing Results

Even though we treat them like vegetables, mushrooms aren’t really plants. They’re fungi and fungi grow much differently than fruits and vegetables. Most food plants, like strawberries, broccoli, and red bell peppers make chlorophyll from sunlight to gain the nutrients they need to grow. Mushrooms don’t make chlorophyll; to get the nutrients they need to grow, mushrooms release enzymes into the forest floor or flora they’re living on to break down the organic matter into a form the mushroom can absorb.

Because most mushrooms that we eat or use today are raised as crops, or cultivated, they are grown on a variety of substrates. Similar to the commercial potting soils you can buy at nurseries and garden stores, mushroom substrates vary widely in quality and the kinds of nutrients within. Mushrooms are really unique in that they can grow on almost anything, such as sawdust, shredded newspaper, and straw.

However, mushrooms are only as nutritious as the substrate they were grown on-even those unique varieties called medicinal mushrooms. While the simple button mushrooms found on pizza are most often eaten for their woodsy taste and texture, the use of medicinal mushrooms is much more complex. These mushrooms are valued because they contain numerous compounds that have been extensively studies by researchers for their ability to activate cells of the immune system.

Researchers have recently discovered that when medicinal mushrooms are grown on a Purple Kculli (pronounced ka-coo-lee) Corn substrate, the resulting mushrooms are jam-packed with powerful and potent disease-fighting compounds. Beautiful Purple Kculli Corn has long been used by the people of the Peruvian Andes as a tasty vegetable, natural food color, and powerful functional food-keeping them healthy and free of disease.

In this issue of Ask the Medicine Hunter, we’re going to talk about four powerful medicinal mushrooms that, when grown on Purple Kculli Corn, have even more potent compounds to prevent and treat cancer and other serious health problems.

Q. How exactly do medicinal mushrooms prevent and treat cancer?

A. Medicinal mushrooms are very complex. They contain numerous compounds that have been extensively studied for their ability to activate cells of the immune system. Some of the most amazing immune boosting compounds in medicinal mushrooms are beta-glucans 1-3, beta glucans 1-6, arabinogalactins, and arabinoxylans – compounds that work “hand-in-hand” with certain cells of the immune system. But to get abundant amounts of these compounds, medicinal mushrooms must be grown on substrates with high levels of nutrients. And the most nutrient dense substrate of all comes from Purple Kculli Corn.

Q. Why is Purple Kculli Corn extract good for growing medicinal mushrooms?

A. You’ve probably heard that brightly colored fruits and vegetables (like beets, broccoli, and blueberries), have more antioxidant power than paler fruits and vegetables (like iceberg lettuce, onions, and garlic). In fact, the deeper the color, the better. And there is no deeper color in nature than the deep purple of Purple Kculli Corn grown in the lush coastal plains of Peru. The kernels from Purple Kculli Corn are not only naturally beautiful, the pigment itself is extremely healthy and have been used by the people of the Peruvian Andes for centuries as both food and food coloring.

Once harvested, the Purple Kculli Corn is naturally processed into an antioxidant-rich extract. When certain medicinal mushrooms are grown on Purple Kculli Corn extract, the Purple Kculli Corn becomes a super-substrate, producing medicinal mushrooms with incredible amounts of the immune-boosting compounds. And when Purple Kculli Corn extract is added to medicinal mushroom formulas the antioxidant power increases, too.

Q. How do the medicinal mushroom compounds fight disease?

A. When bacteria, viruses, or other pathogens are present in the body, white blood cells, or leukocytes, swing into action. Leukocytes work together to defend the body against infections, like colds or the flu, as well as diseases that start within us, like cancer. These disease fighting cells are the backbone of the body’s defense system. And each type of cell works in different ways.

The macrophage, a name that means “big eater,” is a first-strike leukocyte that protects us from disease by, quit literally, devouring invading pathogens. Natural Killer (NK) cells act like sentries – constantly prowling for cancer cells, killing them quickly when they’re discovered. B-cells are the immune system’s military intelligence, seeking out targets and communicating their coordinates, while T-cells are the foot soldiers, destroying the invaders that the intelligence system has identified.

Scientists have long known that medicinal mushrooms help make white blood cells more deadly. But until recently, they weren’t sure how. Research has now shown that macrophages and NK cells have receptor sites specifically for beta-glucans 1-3 and beta-glucans 1-6. When the beta-glucans bind to the macrophages and NK cells, they make the lymphocytes stronger and more lethal. By increasing the lymphocytes’ strength, beta-glucans help them churn out more of the specialized chemical messengers, too.

Arabinogalactins and arabinoxylans, powerful polysaccharides found in medicinal mushrooms, are potent stimulators of the immune system. These compounds increase the activity of interleukins, interferons, and a tumor necrosis factor, all key components in a healthy immune system. When medicinal mushroom extracts with high amounts of Arabinogalactins and arabinoxylans are taken, diseases are dramatically reduced.

Researchers found that complex polysaccharides in four varieties of medicinal mushrooms – Agaricus blazei (Agaricus), Grifola frondosa (Maitake), Coriolus versicolor (Coriolus or Turkey Tail), and Ganoderma lucidum (Reishi) – are serious cancer fighters. The chart below explains how:

Mushroom Health Benefit

Agaricus (Agaricus Blazei)

Agaricus not only contains the greatest number of medicinal compounds, it also contains a powerful anti-tumor polysaccharide that all other medicinal mushrooms are lacking. Recently, 100 women who were receiving carboplatin, a chemotherapy drug used to treat ovarian cancer, volunteered for an important study. Half of the women were given an extract of Agaricus mushrooms, while the other half were given a placebo or dummy pill. The researchers discovered that NK cell activity was significantly higher in the Agaricus group. The women in this group were also less nauseated, fatigued, and wear than the women taking the placebo, an important consideration for people with cancer.

Maitake (Grifola Frondosa)

Maitake is one of the most researched of all medicinal mushrooms. In one clinical study, the effect of Maitake mushroom compounds were studied in ten patients with cancer who were not currently taking any chemotherapeutic drugs. The researchers found that the Maitake not only significantly stimulated NK cell activity, it also repressed the cancer’s growth, and stopped the tumors’ ability to metastasize, or spread to other parts of the body. And in another clinical study, 165 patients with various types of advanced cancer were given Maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, 69% of breast cancer patients, and 62% of lung cancer patients. Plus, when Maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.

Coriolus(Coriolus Versicolor)

Versicolor compounds show great promise as cancer immunotherapy agents in all cancer stages. In one clinical trial, 34 patients with advanced terminal lung cancer were given Coriolus versicolor polysaccharides or a placebo (dummy pill) for 28 days. While the group getting the Versicolor felt less fatigued and sick, very important considerations at the end-of-life, there were no changes in the placebo group.

Reishi (Ganoderma Lucidum)

Reishi mushrooms are too tough to eat, but they’ve been used medicinally for centuries and have been extensively researched. In a safety study to determine Reishi’s effect on blood thinning mechanisms, healthy volunteers received 1.5 gm Reishi or placebo daily for 4 weeks. There were no significant changes in either group and all blood clotting measurements remained within the normal range, demonstrating its safety. In a recent clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.

Not only do Agaricus, Maitake, Coriolus, and Reishi have incredible amounts of immune boosting polysaccharides, when they are grown on Purple Kculli Corn, they also have a much higher ORAC value than mushrooms grown on other substrates.

Q. What are ORAC values?

A. ORAC, or Oxygen Radical Absorbance Capacity, is a measurement of the antioxidant power in fruits and vegetables. The higher the power, or ORAC value, the stronger the antioxidant is against free radicals. While free radicals are made by breathing oxygen and digesting food, and are simply the consequences of being alive, the older we get the more free radicals we make. And the more free radicals we make the more destructive they can be. Free radicals will rip membranes, wreck cells, cripple mitochondria, and ruin DNA. As this damage accumulates, even more free radicals are made. And if not stopped or slowed, this might lead to heart disease, arthritis, diabetes, dementia, and cancer.

Q. How does Purple Kculli Corn increase the ORAC value of medicinal mushrooms?

A. All brightly colored fruits and vegetables have very high ORAC values; and the higher the ORAC value – the greater the antioxidant power. Not only can we measure the ORAC values of fruits and vegetables, we can also measure the ORAC values of mushroom substrate extracts. Purple Kculli Corn extract has an ORAC value of 1789 (measured in umolesTE/gram). Now, remember that mushrooms are fungi, not fruits and vegetables, and they gain most of their nutrients from the ground (or substrate) they are grown on. When mushrooms are cultivated or “farmed” on substrates with a high ORAC value, they will absorb compounds from the substrate giving them a higher ORAC value, too. So growing mushrooms on antioxidant rich, high ORAC value, Purple Kculli Corn yields medicinal mushrooms with high ORAC values as well.

Q. Some mushroom supplements have more than four medicinal mushrooms. Wouldn’t a mushroom supplement with seven mushrooms or more have a higher ORAC value than a supplement with only four?

A. Well, more is not always better – especially when it comes to medicinal mushrooms. Some supplements have a “kitchen sink” selection of mushrooms. The makers of these supplements hope that by adding modest amounts of many mushrooms, they will end up with a product that just might have some health benefits.

Clearly, it’s not how many or how exotic the mushrooms are in a medicinal mushroom supplement, it’s the substrate that mushrooms are grown on that makes the difference.

Q. How can I make sure the medicinal mushroom supplement I buy contains natural and organic mushrooms grown on Purple Kculli Corn substrate?

A. Become a label reader! Medicinal mushroom formulas have a statement showing accreditation from a certifying agency, such as the American Food Safety Institute, International; California Organic Farmer Association, Minnesota; or Crop Improvement Association, on the label, and have met certain criteria. They must be grown without chemicals or pesticides. The growers must be certified as organic mushroom produces by an accredited third party. And the growers must keep a record of their production and handling practices.

Conclusion

Of the nearly 38,000 varieties of mushrooms, Agaricus blazei, Grifola frondosa, Coriolus versicolor, and Ganoderma lucidum have impressive medicinal properties. With a little help from Purple Kculli Corn, these mushrooms can provide even more potent and powerful cancer preventing properties for superior mushroom supplements.

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Date: December 11, 2006 03:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits - Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8

Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release – For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Scientific References
1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L. Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal antiinflammatory drugs. Pharmacological Research Communications 1978; 10(6):557-569.

2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.

3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.

4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.

6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.

7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.

8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.

9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.

10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.

11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.

12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.

13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.

14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.

15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.

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for Great Joint Health buy Best Joint Support at Vitanet

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1438)

Date: September 19, 2006 05:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Drugs Do Not Resolve Our Nutritional Deficiencies

The Soviet Union did a 6 year study of the effects of daily AM and PM supplementation of the diet with Glyconutrients in 10,096 assembly line workers.

In 1973, the number of days absent was 266 with 41.8 percent sick. By 1979, only 11 absences and only 2.7 percent sick.

Another study on 1,000 truck drivers receiving Glyconutrients for six years.

In 1973, 296 had flue, 171 had hypertension and 282 had heart disease. By 1979, only 11 had flu, 5 had hypertension and 3 had heart disease.

The point is, how about the self-insured companies getting a clue, providing the employees with Glyconutrients, lowering their insurance premiums and keeping them at home?

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1390)

Date: February 12, 2006 01:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Acetyl-L-Carnitine

Benefits Supports cognitive function* ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days.2 Hospitalized elderly people taking ALC have shown improvements in mental outlook.3 While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5 Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve function* Brain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC.6 It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine.7 ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.8 Helps supply the brain with energy by improving energetics in the mitochondrion* The acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. 9 Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.10 Stabilizes intracellular membranes* ALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients.11 Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes.12 ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.13 Increases nerve growth factor production* The body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes.14 Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF.15 These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.16 Has a protective influence on brain neurons* Several animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC.17 Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+.18 ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue.19 ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation.20 ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.21 As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption. Safety Suggested Adult Use: 1 to 4 capsules daily. ALC is considered safe and well-tolerated when consumed orally. ALC has been administered in doses as high as 3 grams per day for periods of two to six months, with no reports of serious side effects. Some patients have experienced occasional mild abdominal discomfort, nausea, skin rash, restlessness, vertigo and headache. The severity and incidence of these side effects are reported as minor.22 Scientific References 1. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32. 2. Salvioli, G. Neri , M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exptl. Clin. Res. 1994; 20(4):169-76. 3. Tempesta, E, et al. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs. placebo. Drugs Exptl. Clin. Res. 1987;8(7):417-23. 4. Spagnoli, A et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 1991;41:1726-32. 5. Rai, G et al. Double-blind, placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia. Curr. Med Res. Opin. 1990;11:638-47. 6. Falchetto, S, Kato, G, Provini, L. The action of carnitines on cortical neurons. Can J Physiol Pharmacol 1971; 49(1):1:7. 7. Dolezal, V., Tucek, S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 1981;36(4):1323.30. 8. Passeri, M, et al. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. Int. J. Clin. Pharm. Res. 1988;8(5):367-76. 9. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32. 10. Parnetti, L, et al. Pharmacokinetics of IV and oral acetyl-L-carnitine in multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin Pharmacol 1992;42:89-93. 11. Pettegrew, JW, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiology of Aging 1995;16(1):1-4. 12. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32. 13. Arduni, A, et al. Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 1990;47(26):2395-2400. 14. Taglialatela, G, et al. Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol 1992;44(3):577-85. 15. Taglialatela, G, et al. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol 1994;29(1):55-56. 16. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32. 17. Forloni, G, Angeretti, N, Smiroldo, S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J Neurosci Res 1994;37(1):92-6. 18. Steffen, V, et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol 1995;14(11):865-71. 19. Fariello, RG, et al. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA. Life Sci 1988;43(3):289-92. 20. Calvani, M, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann Ny Acad Sci 1992;663:483-86. 21. Calvani, M, Carta, A. Clues to the mechanism of action of acetyl-L-carnitine in the central nervous system. Dementia 1991;2:1-6. 22. Zdanowicz, M. Acetyl-L-carnitine's healing potential. Continuing Education Module. New Hope Institute of Retailing. October, 2001. -- Buy Acetyl-L-Carnitine at Vitanet ®

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Date: December 27, 2005 09:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Now Foods -QUALITY- High Standards and Attention to Detail

QUALITY “High Standards and Attention to Detail”

• Family Owned and Operated since 1968
• In-House Microbiology Lab
• Member-NNFA and AHPA
• “A” Certified GMP Manufacturer
• 203,000 Square Foot Manufacturing Packaging Facility

As you shop for dietary supplements you’re faced with an almost dizzying array of choices. Naturally, every product claims to be this, that and the other. But you’ve heard the stories in the media of products that don’t live up to their claims. So how do you know who’s telling the truth? Perhaps a better gauge of a product’s quality is the manufacturer and their history. Do they have a legacy of producing quality goods? How long have they been in business? Is their track record good or do they have a history of product recalls and bad press? If you’re responsible for your family’s health and well-being, it pays to do your homework when it comes to the products you purchase for them. NOW® Foods has been manufacturing dietary supplements and whole foods for 35 years.

Companies that thrive and continue to grow for this long don’t do so because they produce poor quality products. They do so by maintaining extremely high standards and paying special attention to every detail, which is the secret to product quality. At NOW® Foods, these high standards and attention to detail are evident in every aspect of our operations, from receiving to production to finished goods, just as they have been for 35 years. You’re committed to buying only the best for your family, and we’re committed to supplying only the best for our customers.

Quality products are made using the highest quality ingredients. NOW Foods purchases raw materials from only the most reputable vendors, who are required to provide detailed specification sheets and lot-specific certificates of analysis for every shipment we receive. These documents provide information on the quality of the raw material and the various analyses used to verify that quality. Shipments that do not meet our quality standards are sent back to the manufacturer with a point by point report card of why the shipment was refused. We simply don’t just accept every shipment that’s delivered to our dock – no ingredient gets a free pass into our production facility. In addition, we also perform random vendor audits throughout each year to ensure that they’re meeting our stringent quality standards. NOW ® Foods is always vigilant when it comes to quality, just as you are. Another way we maintain high quality standards is by choosing to buy and incorporate registered and/or trademarked ingredients into our products. Each of these ingredients are exclusively produced by a company that owns proprietary manufacturing rights and licenses selected companies like NOW® to use these top quality ingredients in their products.

These registered/trademarked ingredients must undergo even more rigorous analysis and controls than other ingredients, and so offer additional assurance that products containing them are properly manufactured and labeled. Additionally, to maintain the integrity of their ingredient’s reputation, the trademark owner will independently test finished products from manufacturers to verify the quality meets their standards and the label claim of the company licensed to use it. You may be familiar with some of the trademarked ingredient NOW® uses such as, Ester-C® vitamin C, Chromemate® Chromium and L-Carnipure® Carnitine.

Scientific analysis of ingredients is extremely important to ensure the integrity of any dietary supplement. NOW Foods has made substantial investments in the development, construction and staffing of numerous inhouse laboratories, including an advanced instrumental analysis laboratory, a “wet lab” and a state-of-the-art microbiology lab. This saves us the time and expense of having to send samples out to commercial labs for analysis. While we use independent labs to verify our in-house test results, our capabilities allow us greater control over product quality and quicker approval of raw material shipments for production, which means fresher products for consumers. Our investment ensures that NOW® will be able to meet ever-increasing demands for accurate product analysis and outstanding product quality. NOW® is unique in the industry in that we annually spend more on Quality Assurance & Control than we do on Marketing and Advertising combined. What good is a lab without qualified people? NOW® employs an expert team of highly qualified scientists and technicians, including four Ph.D.’s. They’re constantly working to develop new and improved analytical methods, and their efforts contribute not only to our product quality but that of the entire industry as well.

This is all great, you say, but what about your facility and the equipment you use to manufacture products? Our 203,000 square foot facility is designed and built to standards that exceed food-packaging guidelines. It supports pharmaceutical-grade operations, which greatly enhances our ability to produce the highest quality products quickly. All this means fresher, more effective products on store shelves for consumers. NOW® Foods is an ‘A’ rated GMP-certified manufacturer, one of the first companies in the industry to attain GMP (Good Manufacturing Practices) certification. We’re also certified by QAI (Quality Assurance International) as an organic manufacturer. As consumers become increasingly demanding of supplement quality and safety, NOW® is ready to meet this demand with sound science and state-of-the-art research, manufacturing, and packaging capabilities. We are certain that our efforts to consistently maintain the highest product quality will help make your natural product purchasing decisions easier.

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Date: December 22, 2005 09:37 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: JOINT HEALTH

Glucosamine & Chondroitin - JOINT HEALTH

Everyone old enough to walk appreciates the value of fl exibility and ease of movement. Unfortunately many of us take such good things for granted. A famous folksinger sang, “You don’t know what you’ve got till it’s gone.” That’s certainly true for millions of Americans who live with stiff and uncomfortable joints.

Fortunately there are a number of nutrients available that provide the vital components of healthy joint structure and function and ease of mobility. These nutrients are referred to as “chondroprotective agents,” and include glucosamine and chondroitin, which supply the raw material necessary to produce new cartilage, and may even help rebuild worn cartilage. Other chondroprotective nutrients and herbs, like Cetyl Myristoleate, MSM, and Boswellin, work synergistically with glucosamine and chondroitin and further support normal joint function To understand how chondroprotective agents work, one must fi rst understand how joints work. The key element in human joints is articular cartilage, the shock-absorbing tissue that connects two bones together and allows pain-free movement. Articular cartilage is comprised of two different molecules, collagen and proteoglycans, with the remainder composed primarily of water (65-85%). Collagen, a protein that binds tissue together, provides elasticity. Proteoglycans, composed of sugars and protein, absorb water, which provides lubrication and resiliency, nature’s shock absorber for your joints. Both compounds are produced by chondrocytes, caretaker cells responsible for the formation and maintenance of cartilage. A defi ciency in any one of the above constituents will increase the likelihood of wear and tear on articular cartilage, which can eventually lead to compromised joint function.

Glucosamine and chondroitin are safe, natural and effective nutrients that support healthy joint function by supplying the materials needed to produce collagen and proteoglycans.

GLUCOSAMINE

Glucosamine is composed of glucose (a sugar) and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG) and proteoglycans (PG). Both of these constituents attract and bind water into cartilage, increasing resiliency. Research indicates that glucosamine may actually help your body repair damaged or eroded cartilage. A number of studies have been conducted on glucosamine sulfate and glucosamine hydrochloride, with a preponderance of positive results. Glucosamine sulfate is considered the more effective of the two. One study from the University of Liege in Liege, Belgium studied the effects of glucosamine sulfate on 212 patients with knee osteoarthritis. Participants took either 1,500 mg glucosamine or a placebo once daily for three years. The study compared joint-space width at enrollment, one year, and at the study’s conclusion.

The 106 patients on placebo had a progressive jointspace narrowing, while participants taking glucosamine experienced no significant joint-space loss, indicating glucosamine may benefi cially modify cartilage structure.3 A study published in the journal Osteoarthritis and Cartilage in 1998 investigated the in vitro effects of glucosamine sulfate on proteoglycan and collagen production by chondrocytes taken from osteoarthritic articular cartilage. The results showed “a statistically signifi cant stimulation of PG production by chondrocytes from human osteoarthritic cartilage cultured for up to 12 days in 3-dimensional cultures.” 4 Another study from Italy enrolled eighty inpatients with established OA. They received either 1,500 mg of glucosamine sulfate or placebo daily for 30 days. The patients treated with glucosamine sulfate experienced a reduction in symptoms almost twice as large and twice as fast as those receiving placebo. Researchers also used electron microscopy of patient’s articular cartilage to support this hypothesis. Patients who received glucosamine sulfate showed a picture more similar to healthy cartilage. The researchers concluded that glucosamine sulfate tends to rebuild damaged articular cartilage and restore articular function.5

CHONDROITIN

Chondroitin is classifi ed as a glycosaminoglycan. It bonds with collagen to form the basis of connective tissue. Chondroitin helps attract fl uid into proteoglycans, thereby bringing nutrients into cartilage and providing shock absorption. While glucosamine helps manufacture and maintain cartilage, chondroitin keeps cartilage from becoming malnourished. Chondroitin works synergistically with glucosamine, and these two nutrients form the basis of most joint health supplements on the market today. A 6-month randomized, multi-center, double-blind, doubledummy study published in 1996 compared the effectiveness of chondroitin versus a popular non-steroidal anti-infl ammatory drug (NSAID) in patients with knee osteoarthritis (OA). One hundred and forty-six patients with knee OA were recruited and separated into two groups; an NSAID group and a chondroitin sulfate (CS) group. The NSAID group was given the NSAID and a placebo for the fi rst month, then placebo alone for months 2-3. The CS group was given the NSAID and CS for the fi rst month, and then CS alone for months 2-3. Both groups were then given 1200mg of CS for months 4-6. “Patients treated with the NSAID showed prompt and plain reduction of clinical symptoms, which, however, reappeared after the end of treatment; in the CS group, the therapeutic response appeared later in time but lasted for up to 3 months after the end of treatment. CS seems to have slow but gradually increasing clinical activity in OA; these benefi ts last for a long period after the end of treatment.”6

NOW® Foods is your source for natural joint support products. Our Extra Strength Glucosamine & Chondroitin is one of our best-selling products, and we also have combination supplements that include MSM, Concentrace® minerals, and more. We also carry both glucosamine and chondroitin as separate products, as well as in powder and lotion forms.

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Date: December 08, 2005 04:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Butterbur Extract Fact Sheet

Butterbur Extract Fact Sheet

LIKELY USERS: People wanting to support healthy blood flow to the brain and healthy neurological function 1-6,10 Those maintaining normal seasonal immune responses 7-10

KEY INGREDIENTS: 75 mg of Guaranteed Potency Butterbur Root (Petasites hybridus) Extract, min. 15 Sesquiterpenes as Petasines; 200 mg of Feverfew Leaf (Tanacetum parthenium) min. 0.4% Parthenolides

MAIN PRODUCT FEATURES: Butterbur (Petasites hybridus) is a native shrub of Europe, North America, and Asia that has been used by herbalists for centuries. Modern scientific studies have demonstrated that Butterbur supports healthy blood flow to the brain and healthy neurological function.1-6, 10 In addition, Butterbur may help to maintain balanced seasonal immune responses.7-10 In a synergistic base of guaranteed potency Feverfew leaf.11-26

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW Butterbur is free of harmful levels of Pyrrolizidine Alkaloids (PAs), the undesirable compounds naturally found in Butterbur, so it is safe to use regularly.

SERVING SIZE & HOW TO TAKE IT: Take one VCap one to three times per day, or as directed by your physician.

COMPLEMENTARY PRODUCTS: Magnesium, Ulcetrol, B-2, B-12, Fish Oil (EPA, DHA), SAM-e, Ginger, Ginkgo Biloba

CAUTIONS: None.

SPECIFIC: Do not discontinue use abruptly; taper off use if discontinuing. Discontinue use at least 14 days before surgery or oral surgery. Use with caution if you have ragweed allergies or blood disorders and let your physician know that you plan to use it before you take it. May be contraindicated for pregnant women.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:

1. Diener HC, Rahlfs VW, Danesch U (2004) The First Placebo-Controlled Trial of a Special Butterbur Root Exract for the Preventio of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 51:89-97.
2. Lipton RB, Gobel H, Einhaupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventative treatment for migraine. Neurology 63:2240-2244.
3. Pothmann R, Danesch U (2005) Migraine Preventiuon in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 45:196-203.
4. Rapaport AM, Bigal ME (2004) Perventive migraine therapy: what is new. Neurol Sci 25:S177-S185.
5. Wu SN, Chen H, Lin YL (2003) The mechanism of inhibitory actions of S-petasin, a sequiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells. Planta Med 69(2):118-124.
6. Wang G-J, Wu X-C, Lin Y-L, Ren J, Shum AY-C, Wu Y-Y, Chen C-F (2002) Ca2+ channel blockin effect of iso-S-petasin in rat aoritic smooth muscle cells. Eur J Pharmacol 445(3):239-45.
7. Lee DKC, Carstairs IJ, Haggart K, Jackson CM, Currie GP, Lipworth BJ (2003) Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy 33:882-886.
8. Lee DKC, Haggart K, Robb FM, Lipworth BJ (2004) Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 34:110-114.
9. Lee DKC, Gray RD, Robb FM, Fujihara S, Lipworth BJ (2004) A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 34:646-649.
10. (No Author) (2001) Petasites hybridus (Butterbur). Alt Med Rev 6(2):207-209.
11. Hayes NA, et al. The Activity of Compounds Extracted from Feverfew on Histamine Release from Rat Mast Cells. J Pharm Pharmacol. Jun1987;39(6):466-70.
12. 2 Groenewegen WA, et al. A Comparison of the Effects of an Extract of Feverfew and Parthenolide, a Component of Feverfew, on Human Platelet Activity In-vitro. J Pharm Pharmacol. 1990;42(8):553-57.
13 Capasso F. The Effect of An Aqueous Extract of Tanacetum parthenium L. on Arachidonic Acid Metabolism by Rat Peritoneal Leucocytes. J Pharm Pharmacol. Jan1986;38(1):71-72.
14. 4 Bejar E. Parthenolide Inhibits the Contractile Responses of Rat Stomach Fundus to Fenfluramine and Dextroamphetamine but not Serotonin. J Ethnopharmacol. Jan1996;50(1):1-12.
15. 5 Prusinski A, Durko A, Niczyporuk-Turek A. [Feverfew as a Prophylactic Treatment of Migraine]. Neurol Neurochir Pol. 1999;33(Suppl 5):89-95.
16. 6 Barsby RW, et al. Feverfew Extracts and Parthenolide Irreversibly Inhibit Vascular Responses of the Rabbit Aorta. J Pharm Pharmacol. Sep1992;44(9):737-40.
17. 7 Pittler MH, Vogler BK, Ernst E. Feverfew for Preventing Migraine (Cochrane Review). Cochrane Database Syst Rev. 2000;(3):CD002286.
18. 8 Pattrick M, et al. Feverfew in Rheumatoid Arthritis: A Double-blind, Placebo Controlled Study. Ann Rheum Dis. 1989;48:547-49.
19. 9 Makheja AM, et al. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostaglandin Leukotri Med. 1982;8:653-60. 20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada . Ottawa , Canada
20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada. Ottawa, Canada.
21. 14 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996:119-21.
22. 15 PDR for Herbal Medicines, 2nd ed. Montvale , NJ: Medical Economics Company; 2000:307.
23. 16 Pribitkin ED. Herbal therapy: what every facial plastic surgeon must know. Arch Facial Plast Surg. Apr2001;3(2): 127-32.
24. 17 Schmidt RJ. Plant dermatitis. Compasitae. Clin Dermatol. Apr1986;4(2):46-61.
25. 18 Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13): 1221-7.
26. 19 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London : The Pharmaceutical Press; 1996:119-21.

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Butterbur at Vitanet ®

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Date: December 07, 2005 01:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Astragalus Fact Sheet

Astragalus Fact Sheet

LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg)

MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides.

ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!).

SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants.

CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
2. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
3. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
4. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
5. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
6. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
7. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
8. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
9. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.
10. Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1103-11. PMID: 15249203
11. Zhang BQ, Hu SJ, Shan QX, Sun J, Xia Q. [Relaxant effect of Astragalus membranaceus on smooth muscle cells of rat thoracic aorta.] Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Jan;34(1):65-8. Chinese. PMID: 15693127
12. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD, Chen J. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett. 2004 Jun 17;363(3):218-23. PMID: 15182947
13. Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem. 2004 Jun;11(11):1423-30.
14. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 521–3. 15. Klepser T, Nisly N. Astragalus as an adjunctive therapy in immunocompromised patients. Alt Med Alert 1999;Nov:125–8 [review].
16. Qun L, Luo Q, Zhang ZY, et al. Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Clin Nephrol 1999;52:333–4 [letter].
17. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: Springer Verlag, 1992, 1056.
18. Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus. Chung Kuo Chung His I Chieh Ho Tsa Chih 1995;15:77–80 [in Chinese].
19. Chen LX, Liao JX, Guo WQ. Effects of Astragalus membranaceus on Left Ventricular Function and Oxygen Free Radical in Acute Myocardial Infarction Patients and Mechanism of Its Cardiotonic Action. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Mar1995;15(3):141-3.
20. Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on Left Ventricular Function of Angina Pectoris. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1994;14(4):199-202,195.
21. Geng CS, et al. Advances in Immuno-pharmacological Studies on Astragalus membranaceus. Chin J Integ Trad West Med. 1986;6:62.
22. Shi HM, et al. Intervention of Lidocaine and Astragalus membranaceus on Ventricular Late Potentials. Zhongguo Zhong Xi Yi Jie He Za Zhi. Oct1994;14(10):598-600.
23. Griga IV. Effect of a Summary Preparation of Astragalus cicer on the Blood Pressure of Rats with Renal Hypertension and on the Oxygen Consumption by the Tissues. Farm Zh. 1977;6:64-66.
24. Kurashige S, Akuzawa Y, Endo F. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine. Cancer Invest. 1999;17(1):30-5.
25. Wei H, Sun R, Xiao W, et al. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep. Sep2003;10(5):1507-12.
26. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:56. American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=984)

Date: December 07, 2005 01:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immune Renew Fact Sheet

Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)

MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.

ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels

SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.

This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.
4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.
5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.
6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].
7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.
8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.
9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].
10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.
11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.
12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.
13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].
14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A Phase I/II Trial. J Med. 1998;29(5-6):305-30.
19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.
20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.
21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.
22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.
23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.
24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.
25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.
27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.
29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.
30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.
31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457
32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807
33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83. PMID: 15380649
34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.

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Date: November 11, 2005 09:32 AM
Author: Darrell Miller (dm@vitanetonline.com)

Benefits of Omega-3 Fatty Acids

Cardiovascular Disease:
Numerous epidemiological and observational studies have shown that omega-3 fatty acids enriched diets are associated with reduction of cardiovascular mortality, myocardial infraction and sudden death. Higher fish intake was associated with decreased incidence of coronary artery disease and cardiovascular mortality in several prospective cohort studies. Putting it in prospective, a minimum of one fish meal a week was associated with a 52% reduction of sudden cardia death.

Randomized clinical trials are adding to the evidence that omega-3s are beneficial in cardiovascular disease, especially from secondary prevention of myocardial infraction.

One of the earliest randomized clinical trials was the diet and reinfraction trial (DART). This trial was designed to examine the effects of dietary intervention in the prevention of secondary myocardial infraction. The subjects advised to increase their intake of oily fish had a 29% reduction in 2-year all-cause mortality. This ovservation lead to the hypothesis that omega-3 fatty acids might protect the myocardium against acute ischemic stress. A post hoc analysis of patients receiving fish oil supplements (900mg/day of EPA and DHA) suggested that the protective effect was attributed to omega-3 fatty acids.

Another randomized placebo-controlled trial of patients admitted to the hospital with suspected acute myocardial infraction showed that supplementation with 1.8 g of omega-3 (EPA and DHA) for on year decreased total cardiac events by 29%. Both total cardiac death and nonfatal myocardial infractions were also reduced by 48%.

The largest randomized clinical trial to test the efficacy of omega-3 fatty acids for secondary prevention of cardiovascular disease is the GISSI-prevention study. From 1993 to 1995, 11,324 patients surviving myocardial infraction were randomly assigned either vitamin E (300mg daily, as synthetic-a-tocopherol), omega-3 fatty acids (1 g daily, standardized to 850 mg EPA and DHA), both or none. Compared with the control group, patients taking the fish oil showed a 15% reduction in the primary end point of death, nonfatal myocardial infraction, and nonfatal stroke. Patients supplementing with vitamin E online showed no benefit.

With this mounting data, the American Heart Association (AHA) recommends eathing at least two servings of fish per week (particularly fatty fish). The FDA has also announced a qualified health claim linking a reduced risk of coronary heart disease with the long-chain omega-3 polyunsaturated fatty acids.

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Read about the benefits of Omega 3 at Vitanet ®

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Date: October 28, 2005 05:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Best Bladder Support

Benefits

• Maintains normal urinary sphincter tone*

Crateva Nurvala

Crateva nurvala is an ancient herb used for generations in the traditional Indian sys tem of medicine kn own as Ayurveda. Ancient Ayurvedic practitioners used it as an internal purifier that helped maintain homeostasis and balance. This herb has a long history of use as the herb of choice to maintain healthy urinary tract and bladder function. The tree that is the source of this herb is often found growing along the banks of rivers in the sub-Himalayan regions of India. The stem bark is the part used to benefit urinary health.1

Studies with Crateva nurvala have been conducted in India demonstrating the herb's efficacy in maintaining healthy urinary bladder function. Animal studies with the water extract of Crateva have shown that the herb has the ability to increase the tone of smooth muscle and skeletal muscle. In a rat model of kidney stones, researchers were able to show that rats given Crateva extract had significantly smaller stones than in the untreated group.3 In addition, a study conducted in dogs showed that the animals receiving Crateva extract for 40 days had significantly higher maintenance of bladder tone than control animals.

2 A tea prepared from the bark of the plant was given to 30 individuals (50 ml twice daily). Baseline measures of urinary function and bladder tone were assessed at the beginning of the study. It was found that when compared to baseline, the Crateva tea showed a high ability to promote healthy urinary function and enhance bladder tone in these individuals after 3 months of use.2

Equisetum Arvense

Equisetum arvense, also known as horsetail, is a traditional plant that is especially rich in silica and other essential minerals. It is a member of a prehistoric family of plants that is now one of the most common species in northern temperate climates. In addition to being extremely rich in the mineral silica, horsetail also contains saponins and flavonoids. The combination of these constituents is thought to be responsible for its beneficial properties.

4 Traditional cultures have used horsetail over the years for its various healing properties. Traditional herbalists recommended horsetail for healing wounds be cause of its noticeably astringent effects. Internally,horsetail was used to promote healthy digest ive function.5

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The “Power” of trace Minerals…

Date: October 08, 2005 11:56 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The “Power” of trace Minerals…

The “Power” of trace Minerals…

These articles piqued hartley’s interest with information about the amazing results people were receiving from drinking a little bit of sea water each day. This led him to research the great salt Lake, an inland sea located near his home. He found that the Great Salt Lake not only had the same minerals and balance discussed by George Crane, but that it was 6 to 10 times more concentrated than regular sea water without the pollution. Hartley knew there was a need for these minerals himself and had seen results from other people that the company was established with initial product sales.

Science was slow to provide answers as to why the minerals from this desert sea caused such a dramatic and varied results in people, but Hartley knew from his growing stack of testimonials that the company’s first product, Inland sea water, was effective. He and his wife, Gaye, founded Trace Minerals Research in 1968 and started selling pure Great Salt Lake water to the public and a short time later, they discovered how to use nature’s own processes to remove the sodium, thereby creating low-sodium, Concentrace TraceMineral Drops.

Hartley and Gaye founded their company on the principle that nutritional supplements should get results and that if a customer does not actually feel an improvement in their health, they should not have to pay for it. This same principle is still evident today in Trace Mineral Research.

Not a single bottle of product leaves our manufacturing facility unless we can confidently back it up with the guarantee of “Feel the Difference or your Money Back.” This guarantee is made possible because minerals and trace minerals needed by Americans today are found in rich abundance, a natural balance and a highly assimilable principle ionic form from the Great Salt Lake. Trace Mineral Research sent most of their products into development because of the spectacular results many people were already discovering from low sodium ConcenTrace and Trace Mineral Drops. The company then combined their formulas of vitamins, herbs, enzymes and other nutrients to enhance the specific benefits people were reporting.

Trace Minerals Research now has a complete line of highly effective nutritional supplements each backed by our guarantee of “Feel the Difference of Your Money Back”. These products are also backed by research and we are continually researching new information on our existing and new products.

Our Philosophy at Trace Mineral Research has always been that the Earth was created with the prefect balance of all the nutrients that humans need to be healthy and happy. The only problem is that over the years humans have become victims of the water cycle. Dr. U. Aswathanarayana states, “Soil erosion leads to the depletion of essential nutrients elements in crops grown in depleted soil. When people consume a diet derived from such crops, the intake of essential elements becomes inadequate. This leads to the impairment of the relevant physiological functions, and causes disease.” For millions of years, every sprouting seed and towering tree has dissolved minerals to ionic form and raised them from the depths of the soil where they could easily be washed away by water. To add to this problem, aggressive farming has further depleted the soils. Furthermore, many fertilizers and pesticides bind trace minerals in the soil so that fewer minerals are absorbed by fruits and vegetables. The importance of minerals in the soil and their effects on human health are not new concepts. Dr. Alexis Carrel, Winner of the Nobel Prize in Medicine in 1912, states, “Soil is the basis of all human life and our only hope for a healthy world… All of life will be either healthy or unhealthy according to the fertility of the soil. Minerals in the soil control the metabolism of cells in plants, animal and man … Diseases are created chiefly by destroying the harmony reigning among mineral substances present in infinitesimal amounts in air, water and food, but most importantly in the soil. Even the AMA recognized the importance of minerals in our diet. “Variations in the distribution of certain minerals in the environment are known to have an effect on health.

The Lack of minerals in our soil is evidenced through the need for constant fertilization. Plants need nitrogen, hydrogen, oxygen, chlorine, carbon, boron, sulfur, potassium, magnesium, phosphorous, iron, zinc, copper, manganese, and molybdenum, some of which are commonly replaced through fertilizers to provide maximum crops through minimum investment. However, humans are known to additionally need calcium, sodium, fluorine, bromine, chromium, iodine, silicon, selenium, beryllium, lithium, cobalt, vanadium and nickel, which would not necessarily be replaced through fertilization for plants.

This continual cycle of soil depletion and minor replacement of minerals through fertilization in conjunction with a diet of processed foods has left many Americans deficient in minerals and trace minerals. This does not need to follow the water cycle. As water goes through the constant cycle from evaporation to precipitation, minerals are transported through rivers and streams where it is then collected in the seas thereby creating a natural equilibrium.

Today, Trace Minerals Research harvests minerals and trace minerals from the Great Salt Lake, a uniquely rich and pure desert sea. These minerals are the basis for each of their unique products and help provide a strong foundation for balanced supplementation.

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Celadrin - Benefits

Date: July 27, 2005 11:09 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Celadrin - Benefits

Benefits

Increased Range of Motion in Joints*

Research has shown that Celadrin can have an impact on improving the range of motion in joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin for 2 months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.1 Another study conducted on Celadrin published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.3

Maintains Joint Comfort*

The anti-inflammatory actions of Celadrin have been demonstrated by one double-blind, placebo controlled trial that showed Celadrin, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin may work by down-regulating the effect of certain precursors of the body’s inflammatory response.1

Safety

Suggested Adult Use: One capsule three times daily, with or without food.

Scientific References
1. Hesslink R Jr., et al. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatology 2002;8:1708-1712.

2. Anonymous. Monograph: Glucosamine sulfate. Alt Med Review 1999;4:3;193-195.

3. Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatology 2004;4:767-74.

4. Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: a controlled clinical evaluation. Curr Med Res Opin 1980;7:104-109.

5. Rovati LC. Clinical research in osteoarthritis: design and results of short-term and long-term trials with disease modifying drugs. Int J Tissue React 1992;14:243-51. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.

6. Bassleer C, et al. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis and Cartilage 1998;6:427-434. Med. 2002 Oct 14;162(18):2113-23.

7. Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-56.

8. Macario, J. T., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68. 9. Kraemer WJ, et al. Effect of acetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol.2004 Apr;31(4):767-74. 10. Kraemer WJ,et al. Acetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. J Strength Cond Res.2005 May;19(2):475-80.

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RECENT RESEARCH

Date: July 15, 2005 09:16 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: RECENT RESEARCH

RECENT RESEARCH

A recent study (August, 1996) exploring the effect of Hypericum perforatum on depression re vealed some fairly stunning results. The British Medical Jo u rn a l published the results of one major studies, which consisted of twenty - three randomized trials, including a total of 1757 outpatients with mainly mild or moderately seve re depressive disorders. Testing was conducted with single preparations and combinations of extracts of the plant, and with placebo and anther drug treatment. As just mentioned, the results were very promising. In all aspects of the study, Hypericum extracts were shown to be “significantly superior” to placebo and similarly effective as standard antidepressants. There were nearly twice the number, percentage-wise, of dropouts due to side effects from the standard drugs than those taking the Hypericum extracts. Side effects occurred in eighty-four patients using standard antidepressants, while only fifty patients taking the Hypericum extracts experienced side effects. And the scores on the Hamilton depression scale, which measures severity of one’s depression, showed those taking Hypericum treatments scored slightly higher than those taking the standard antidepressant and significantly higher than those taking the placebo. 9 This study provides some firm ground for St. John’s wort to stand on in the treatment of depression, both in sheer numbers and its quality of treatment.

Another contemporary study, carried out in 1995 by Witte, et. al, showed the Linde study to be accurate in its findings. This particular study, carried out as a multicenter, placebo-controlled double-blind trial, used a highly concentrated Hypericum preparation to treat ninety-seven outpatients. The course of the illness was assessed with the Hamilton Depression Scale, the von Zerssen Depressivity Scale and the Clinical Global Impression Scale. The authors of the study noted this in their abstract:

Treatment resulted in an appreciable improvement in the symptoms of depression, and the seventy percent response rate (n=43) corresponded to that of chemical antidepressants. The preparation also showed an anxiolytic effect. The substance [hypericum] was extremely well tolerated, and no side effects were reported by any of the patients.10 Again, this study’s findings correlate that of the Linde and other studies in that treatment with Hypericum is at least as effective as standard synthetic antidepressants without producing near the number of side effects.

The Nursing Times also reported on recent findings dealing with Hypericum’s effect on depression. Stating that psychiatric medications are notorious for their undesirable side effects, and that the need for safer antidepressants is widely acknowledged, the blurb refers to a double-blind study, done by G. Harrer and H. Sommer (published in Phytomedicine, 1994 (1): 3-8), using St. John’s wort on 105 patients experiencing mild to moderate depression. They were aged twenty to sixty-four and had diagnoses of “neurotic depression or temporary depressive mood.” Patients were divided into two groups and monitored over four weeks, with one group receiving 300 mg of Hypericum extract three times daily and the other group receiving a placebo. All patients received psychiatric evaluations before the start of the study and after two and four weeks of treatment.11

The results of the study support the findings of other recent studies dealing with Hypericum and depression: 67 percent of the Hypericum group had responded positively to the treatment without any adverse side effects, whereas only 28 percent of the placebo group displayed any improvement. Harrer and Sommer state that the patients treated were experiencing strictly mild forms of depression; combining this with the study’s results and the results of other studies suggest that Hypericum treatment can be a very effective treatment for mild to moderate depression without severe side effects. The authors themselves even recommended that Hypericum should be considered as a remedy of choice. 12

These and other studies point to the strong possibility of using St. John’s wort, and specifically hypericin, on a wide scale to treat various forms of depression. Linde’s study suggests that St. John’s wort may have its most valuable asset in that of few or no side effects, something many sufferers of depression are very concerned about. The authors do note, however, that more research is necessary, especially in determining the severity and nature of depression, length of treatment, treatment dosage, preparation of Hypericum extracts, and occurrence of long-term side effects. Nevertheless, the results of this study and others are extremely promising for the millions of those who suffer from depression.

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Pain - Post Op and Relaxation

Date: July 13, 2005 09:24 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pain - Post Op and Relaxation

Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR.

"Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music.

Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good.

"These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization.

Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz.

On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed.

Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery."

Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill.

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Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association.

The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998.

A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study.

There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity.

Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density.

The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group.

These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70.

"We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research.

"Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus.

As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D.

Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine.

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Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds.

"The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander.

"When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt."

Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain.

These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood.

"This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added.

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Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher.

Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal models, natural killer cell activity was suppressed by physical stress or surgery, resulting in a significant increase in tumor development.

These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study.

"We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University.

Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery.

The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page.

"Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk."

The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.

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HAWAIIAN NONI (Morinda citrifolia)

Date: July 11, 2005 08:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HAWAIIAN NONI (Morinda citrifolia)

INTRODUCTION

In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:

kidney disease menstrual

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Immune Health - Herbs to Maintain A Healthy Immune System

Date: July 01, 2005 04:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immune Health - Herbs to Maintain A Healthy Immune System

Immune Health By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt The immune system has been receiving a lot of media attention, especially since the rise in recognized immune system deficiency diseases. The efficient functioning of the immune system is of paramount importance to everyone, adults and children alike, since it controls our ability to fend off illness, whether it is a common cold or more deadly disease. The immune system is made up of a combination of specialized cells, chemicals, tissues and organs. These include the lymph nodes, thymus gland, spleen, bone marrow and tonsils, as well as specialized white blood cells, which recognize and engulf invading microorganisms and cellular debris.

The ability of the immune system to function optimally is influenced by many factors. These include inherent genetic makeup, environmental influences (such as pollution, pesticides, hormones, artificial flavoring/colorings in food), obesity, stress levels, exposure to infective agents, etc. Specific research suggests that consuming excessive amounts of sugar interferes with immune function. We can aid our immune system by eating a high amount of organic green vegetables, whole grains and nuts, while cutting down on 'junk food' consumption. Stress reduction, through prayer, meditation, yoga and moderate exercise can also help.

Herbs may be used in two different ways to help the immune system. Tonics strengthen the immune system over time, while strong immune system stimulants have a more immediate action, and are used during an acute infection.

Tonics

Herbal tonics work to help maintain a dynamic balance in the body and usually need to be taken long-term. Astragalus is said to build "Wei chi". "Chi" is the Chinese concept of life energy force. "Wei chi" is thought of as 'protection'. Current scientific studies confirm the positive benefits of Astragalus on the immune system. One study by the National Cancer Institute demonstrated Astragalus' ability to help strengthen resistance of the immune system, especially to viral infections. Reishi, called the "mushroom of immortality", has been used for centuries as an overall tonic. Chinese physicians have used Ligustrum berries specifically for their immune-enhancing activities. They are often combined with Astragalus for a synergistic effect. Coptis is another Chinese herb that contains the bitter yellow compound, berberine. This herb helps the immune system prevent infections. Many of these herbs can be found in the unique combination formula called Immunotonic™ (alcohol-free). Immunotonic™ offers the ideal way to experience the benefits of many herbs in one convenient supplement.

Other immune system tonic herbs include Siberian Ginseng and Schisandra. Siberian Ginseng is an adaptogen that helps to balance the immune system. It gives strength and fortitude, especially when dealing with environmental stress. Schisandra has been shown to build non-specific resistance, improve brain function, increase work capacity and build strength.

Immune Stimulants

Osha Root has been used traditionally by both Chinese and Native Americans (who called it Chuchupate) for colds and flues, sore throats and other health ailments requiring a higher level of immune support. Echinacea is a well-researched and respected immune system stimulant. (Refer to our Echinacea article for further information). It helps increase the activity of white blood cells, which engulf invading microorganisms. Thuja is an herbal extract from the Northern White Cedar tree. It is a strong immune stimulant that Native Americans used for colds, coughs, bronchitis and other respiratory infections. Possibly the mushroom with the greatest capability of stimulating the immune system is the Maitake. It is known as the "dancing mushroom" because it was so highly prized that whoever found some would dance for joy. Maitake contains specific chemical components that have been scientifically studied for their strong immune enhancing effects; (refer to Maitake Bio-Beta-Glucan™ article for further information). Nature's Answer® combines these herbs in Immune Boost™, a combination formula for use during acute illness and infections. Try it along with the combination formula Echinacea & Goldenseal. Nature’s Answer® offers a selection of all these herbs in liquid and/or capsule forms. Check with your local health food store, or visit www.naturesanswer.com, for more information.

For Kids

Children can often use a boost to their immune system to help ward off colds and flues. Nature's Answer® comes to the rescue with three alcohol-free formulas specifically designed for their special needs - E-KID-nacea™, E-KID-nacea Plus™, and NatChoo™. All of these outstanding formulas help promote a healthy immune system.

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GARLIC: A NATURAL IMMUNITY BOOSTER

Date: June 25, 2005 10:05 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GARLIC: A NATURAL IMMUNITY BOOSTER

GARLIC: A NATURAL IMMUNITY BOOSTER

With the arrival of new and frightening viral diseases like AIDS and flesh eating bacteria, boosting immunity is receiving new attention. Because these types of diseases have no effective cures or treatments, strengthening the body’s ability to fight off infection has become even more important.

Garlic has an abundance of sulphur containing amino acids and other compounds that seem to initiate increased activity in the immune system. For example, macrophages, which kill invading pathogens are stimulated by the presence of garlic.20 The Journal of the American Medical Association states, “it [Garlic] may become known as one of the grand conductors of the body’s immune symphony,”21 Several studies have shown that garlic stimulates immune function by making macrophage or killer cells more active. In so doing, garlic can prevent the onset of colds and fevers by increasing resistance to infection and to stress. It is common knowledge now that stress can compromise immune function. We are constantly assaulted by inadequate nutrition, cigarette smoke, physical injury, mental tension, and chemical pollution. Recently, the notion that vaccinations may also tax the immune system has emerged. In light of the enormous pressure which our immune systems sustain, supplemental nutrients like garlic are clearly needed.

Unfortunately stress, is here to stay and affects us daily through poor diets, environmental pollution and nervous tension. One study from Japan revealed that when mice were exposed to stress, their immunoglobulin production decreased making then more susceptible to infection. When Garlic extract was added to their diets before experiencing stress, their immune systems were protected to some degree.22

Another reason why garlic is such a powerful immune system booster is offered by a medical doctor. Concerning garlic, Dr. Robert Atkins, M.D. of New York City has said: “Garlic is an important nutritional food, The most reasonable explanation for its effectiveness [as a contributor of power to the immune system] is that it picks up toxic materials and transports them out of the body.”23 The food factors contained in garlic also play a role in beefing up the body’s defenses against disease. Garlic is full of nutrients including 17 amino acids. Recent studies have found that the changes which occur in the immune system when autoimmune disease is present are the same as those found in malnutrition.24 Garlic is one of the best immune system fortifiers available.

remarkable content of germanium alone offers excellent immunostimulation. In addition to germanium, Garlic contains thiamine, sulfur, niacin, phosphorous, and selenium. Mother Nature knew what she was doing when designing garlic for human consumption.

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GARLIC AND CARDIOVASCULAR HEALTH

Date: June 25, 2005 09:59 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GARLIC AND CARDIOVASCULAR HEALTH

GARLIC AND CARDIOVASCULAR HEALTH

Recent research has supported the fact that garlic shows excellent potential in the treatment of cardiovascular diseases. Disorders of the heart and the circulatory system claim more lives than any other disease. It is the obstruction or clogging of the coronary arteries which causes more deaths that any other factor. The arteries, which supply the heart with blood and oxygen, become increasingly narrower as plaque builds up over time. When blood supply becomes so restricted that a certain portion of the heart is deprived of oxygen, a heart attack occurs.

The two greatest predictors of heart disease are high blood pressure and high blood serum cholesterol levels. Both of these determinants are directly impacted by the therapeutic action of Garlic. What is particularly relevant about the role of Garlic in coronary heart disease is that several studies done on rabbits found that even pre-existing atherosclerotic deposits and lesions could actually be reversed if garlic was consistently consumed.4

Granted, the above study has not been performed on humans, however, its implications are extremely significant. It is important to remember that it is not always what we are eating that causes heart disease, but what we are not eating. Studies like the one just described suggest that even if our diets were high in cholesterol, adding chemical compounds like the ones found in garlic may keep us from developing cardiovascular disease. This might explain why some cultural groups which consume high fat diets do not suffer the coronary consequences so typical of our population.

What is particularly exciting about the potential of garlic for anyone suffering from heart disease is that it can help reverse the disease and substantially reduce the risk of a second heart attack. The longer garlic is used, the better its results are. For example; people who have heart disease showed more improvement after the third year of garlic therapy than before. A possible explanation for this is that using garlic consistently over time progressively reverses hardening of the arteries, therefore the longer the garlic usage, the less the risk of heart attack.5 The New York Times ran an article on garlic in their September 4, 1990 edition. Concerning heart disease and garlic, it stated:

“...most exciting to those attending the conference, which was co-sponsored by Pennsylvania State and the Federal Department of Agriculture, were the results of a three year study in India among 432 coronary patients who had already suffered one heart attack. The patients were randomly divid ed into two groups, with one group receiving daily supple ments of garlic juice in milk. Those who took the garlic sup plements suffered fewer additional heart attacks, had lower blood pressure and serum cholesterol levels and were less likely to die during the study. After three years, nearly twice as many patients had died in the group not taking garlic . . . Patients who drank the garlic supplement were more likely to report such subjective benefits as an increase in vigor, energy and sexual desire, improvements in exercise tolerance, and a decrease in joint pains and asthmatic tendencies.”

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CLA and Cancer

Date: June 22, 2005 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CLA and Cancer

CLA and Cancer

Because of Pariza’s 1979 research, some of the earliest studies done on CLA were to see if it could block the development of cancer. Dr. Pariza and his colleagues at the University of Wisconsin/Madison’s Food Research Institute in Madison took extracts from beef that they knew had “mutagen modulators” (this was before they isolated CLA.).15 They took two groups of mice, to one they applied this extract on their skin. On the other group, they did not apply the extract on the skin. Then, on both sets, researchers put a cancer-causing substance called dimethylbenaanthracene—DMBA for short—and applied it to the skin.

Sixteen weeks later, doctors counted the mice that had tumors and how many tumors each of those mice had. The number of mice with tumors was 20 percent lower when given the beef extract, and, significantly, the numbers of tumors on those mice that did develop cancer was half what it was on the untreated mice. This meant that this extract could, perhaps, prevent some cancers in mice and, slow tumors after they develop. (Today, Pariza writes that CLA inhibits cancer development at various stages, from initiation to metastasis.)16 After isolating CLA by itself, Pariza and others found that CLA also cut the incidence of skin tumors.17

Scientist Clement Ip at the Roswell Park Cancer Institute in Buffalo did a similar study using DMBA with rats, this time feeding different amounts of CLA into the diet and over a longer period of time. He and his team measured how many breast tumors these rats developed. As might have been expected with the earlier work, 20 percent fewer animals developed the tumors—among those receiving the most CLA—than the rats that received none, and the total number of tumors that developed was 60 percent less. In general, the data showed that the more CLA, the greater the protective effect.18 This is significant in the human world because many researchers see a link between a woman’s consumption of fat and her risk of getting breast cancer, and CLA could help modulate that. Any research to lower a woman’s chance of contracting breast cancer is useful. Today in the United States, as many as one in eight will contract the dread disease.19 In 1990, Dr. Pariza and his colleagues also found a lower incidence of cancers in parts of the stomach.20 Rats were given something called 2-amino-3-methylimidazo (4,5-f]quinoline, which can give them colon cancer. Again, the total number of aberrant growths was lower for those given CLA compared with those given safflower oil, which is rich in essential oils but not so high in CLA.21

Does this mean that CLA will prevent cancer in humans? Perhaps. You might even say probably—in some circumstances Still, science can be imprecise in predicting cancers from animal models to humans, and scientific tests must be controlled in ways that don’t mimic the complexities and confounding factors of daily life. Few of us, for example, will be exposed daily to DMBA. T h e re f o re, all the science says for certain is that CLA seems to hinder the development of cancer in these animals when the cancer is caused by one particular substance. T h a t’s a little way, at least, from saying it pre vents cancers in humans.

However, the animal models are encouraging, and often meet mathematical tests to be “statistically significant.” In fact, scientists have taken to saying CLA has an anti-carcinogenic effect without hedging. Ip himself says, “CLA is more powerful than any other fatty acid in modulating tumor development.” 22 Indeed, so excited have many scientists become that some say one day governments may want to fortify our foods with CLA much the way we fortify our morning bran flakes with vitamin C.23 Furthermore, since at least several ways of giving different species of animals cancer have been studied, and in all of the tests, cancer was hindered, it gives better evidence to the notion that CLA hinders cancer in humans as well. Pariza wrote, “Few anticarcinogens, and certainly no other known fatty acids, are as effective as CLA in inhibiting carcinogenesis in these models.”24 This is clear language saying scientist believe this to be a powerful nutrient in the war against cancer. However, until human research is completed, and human research is underway, the positive effects of CLA on humans as a possible preventative of cancer best be considered preliminary.

Another important point about this is: Since the breakdown and changing of fats and fatty acids like CLA occur in the liver, CLA may have unknown effects on this vital organ. One study showed that fats increase in the livers with the increase of CLA in the diet.25 Could this lead to an increased risk of liver cancer?

Scientists do not have a complete answer to that question either.26 Pariza says, however, that such problems of fat accumulation do not occur in higher mammals, and is something specific to mice and some rats.27

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Mental Edge - Support proper Brain Function...

Date: June 03, 2005 06:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mental Edge - Support proper Brain Function...

Mental Edge

Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MENTAL EDGE® is a Bio-Aligned Formula™ that supports the interdependent body systems involved with healthy brain function. These include neurotransmitter production, myelin sheath generation, stress response, energy metabolism, and antioxidant defense.

Mental Edge®: A Bio-Aligned Formula™

Many scientists believe that only a small portion of the brain is fully utilized. MENTAL EDGE is a literal multivitamin for your brain. This comprehensive herbal-nutrient formula optimizes brain function by addressing the multiple body systems involved with cognitive health.

Neurotransmitter Production

Neurons (nerve cells) communicate with each other when neurotransmitters (brain chemicals) cross a small gap called a synapse to convey a message from one neuron to the next. Second messengers help transmit the message from the membrane of a receiving neuron to its inner environment. MENTAL EDGE supports neurotransmitter production with L-glutamine, L-phenylalanine, L-pyroglutamic acid, taurine, L-tyrosine, manganese, vitamins B-1 and B-6, and inositol.

Acetylcholine Production

Acetylcholine is one of the most important neurotransmitters. It is vital for memory and muscle movement. The ingredients DMAE, phosphatidylcholine, L-pyroglutamic acid, vitamin B-5 and choline are precursors to acetylcholine. DMAE is particularly important because it crosses the protective blood-brain barrier more easily than the others. DMAE also enhances mental concentration.

Stress Response

Adaptogenic herbs help provide the brain with the support and energy it needs to deal with the physical and mental stresses of an ever-changing environment. MENTAL EDGE supports stress response with the botanicals gotu kola, schizandra, and Siberian ginseng, and with the nutrients taurine, calcium, magnesium, potassium, vitamins B-5 and C, and inositol.

Energy Metabolism

Just as every cell needs the proper nutrients to survive, so do neurons. The brain accounts for 2% of our body weight, yet uses 15% of our total energy supply. Adequate levels of energy-generating nutrients are vital to the high-powered functioning of this organ. MENTAL EDGE supports energy generation with ginkgo biloba, L-glutamine, calcium, magnesium, manganese, potassium, zinc, B-vitamins, biotin and folic acid.

Myelin Sheath Generation

Myelin, composed of fat and protein, makes up the myelin sheath that forms a protective insulating covering around certain nerve fibers. Properly formed myelin increases nerve impulse conduction. MENTAL EDGE contains vitamins B-5 and B-12, which are needed for myelin sheath generation.

Lifestyle Tips for Cognitive

Health: A Strategy for WellnessSM Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a highfat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Long-term anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities through the use of memory aids such as “to-do” lists, notes, or calendars.

Neurotransmitter Production: L-Glutamine, L-Phenylalanine, L-Pyroglutamic Acid, Taurine, L-Tyrosine, Manganese, Vitamins B-1 & B-6, Inositol

Acetylcholine Production: DMAE, Phosphatidylcholine, L-Pyroglutamic Acid, Vitamin B-5, Choline

Antioxidant Defense: DMAE, Ginkgo Biloba, Zinc, Vitamin C

Stress Response Gotu Kola, Schizandra, Siberian Ginseng, Taurine, Calcium, Magnesium, Potassium, Vitamins B-5 & C, Inositol

Energy Metabolism: Ginkgo Biloba, L-Glutamine, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6, & B-12, Biotin, Folic Acid

Myelin Sheath Generation: Vitamins B-5 and B-12

*The term symptom as used above refers to the effects of nutrient shortages or imbalances and is not related to the diagnosis, treatment, cure, or prevention of any disease.

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VitaNet ®
VitaNet ® Staff

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CHOLESTEROL LEVELS

Date: May 18, 2005 06:16 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CHOLESTEROL LEVELS

CHOLESTEROL LEVELS

High cholesterol levels have been linked to many serious conditions such as heart disease and cancer. Acidophilus seems promising in helping to lower cholesterol levels. It may work by converting cholesterol to coprostanol which is not absorbed in the body; thus working to lower overall body cholesterol levels.13 Some research has found that Lactobacillus acidophilus may help to lower blood cholesterol levels.14 Blood cholesterol levels of 54 volunteers were monitored. Volunteers were given either milk or yogurt containing Lactobacillus acidophilus. After one week, the individuals given the yogurt had lowered their choles- terol levels by five to ten percent.15

A study involving pigs also found beneficial effects in lowering cholesterol using Lactobacillus acidophilus. Pigs were fed pure crystalline cholesterol. One group received acidophilus in their diet while another was not. The animals receiving the acidophilus showed lower gains in serum cholesterol levels.16

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VitaNet ®
VitaNet ® Staff

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Garlic as a Lipid Lowering Agent-A Meta-Analysis

Date: May 12, 2005 12:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garlic as a Lipid Lowering Agent-A Meta-Analysis

Garlic as a Lipid Lowering Agent-A Meta-Analysis

Author:
Silagy C, Neil A

Source:
Journal of the Royal College of Physicians of London. 1994; 28(1):39-45.

Abstract:
Garlic supplements may have an important role to play in the treatment of hypercholesterolaemia. To determine the effect of garlic on serum lipids and lipoproteins relative to placebo and other lipid lowering agents, a systematic review, including meta-analysis, was undertaken of published and unpublished randomized controlled trials of garlic preparations of at least four weeks duration. Studies were identified by a search of MEDLINE and the ALTERNATIVE MEDICINE electronic databases, from references listed in primary and review articles, and through direct contact with garlic manufacturers. Sixteen trials, with data from 952 subjects, were included in the analyses. Many of the trials had methodological shortcomings. The pooled mean difference in the absolute change from baseline to final measurement in mmol/l) of total serum cholesterol, triglycerides, and high-density lipoprotein (HDL)-cholesterol was compared between subjects treated with garlic therapy against those treated with placebo or other agents. The mean difference in reduction of total cholesterol between garlic-treated subjects and those receiving placebo (or avoiding garlic in their diet) was -0.77 mmol/l (95% CI: -0.65, -0.89 mmol/l). These changes represent a 12% reduction with garlic therapy beyond the final levels achieved with placebo alone. The reduction was evident after one month of therapy and persisted for at least six months. In the dried garlic powders, in which the allicin content is standardized, there was no significant difference in the size of the reduction across the dose range of 600-900 mg daily. Dried garlic powder preparations also significantly lowered serum triglyceride by 0.31 mmol/l compared to placebo (95% CI: -0.14, -0.49). HDL-cholesterol was non-significantly lowered by 0.04 mmol/l (95% CI: -0.11, 0.03 mmol/l). Side effects from garlic therapy, other than odor, were rare. In conclusion, use of garlic therapy, either as dried garlic preparations (in doses as low as 600 mg per day) or as fresh, high allicin yielding garlic (10-20 g per day) appears significantly to reduce total serum cholesterol over a 1-3 month period. However, more rigorously designed and analyzed trials are needed. --
VitaNet®
VitaNet ® Staff

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Date: May 09, 2005 06:10 PM
Author: Darrell Miller (dm@vitanetonline.com)

It's in the Blood

Natural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul Bubny

The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.

“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.

“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”

At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.

While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”

Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”

And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”

Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”

King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”

Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.

"Blur of Products"

With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”

To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:

Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.

Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.

Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”

“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”

On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.

Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.

Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.

Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.

Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.

Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”

Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.

“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.

Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.

Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.

“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.

For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”

Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.

Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.

Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.

Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.

Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.

“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”

Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”

Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.

However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”

Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”

Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.

Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”

New Weapons

There are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise.

With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”

Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.

“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR

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