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How ZincMunity Can Help Support Your Immune System
December 14, 2022 05:27 PM
Source Naturals Wellness ZincMunity 50 mg Bio-Aligned Zinc provides a unique blend of vitamins, minerals, and herbs that work together to support your immune system. This product is designed for individuals looking for an easy and efficient way to get the essential vitamins and minerals their bodies need on a daily basis. Read on to learn more about what this product has to offer.
What Does ZincMunity Contain?
ZincMunity contains a diverse array of nutrients including Vitamin A, Vitamin D3, B-6, Magnesium, Zinc, Copper, Alpha Lipoic acid, Quercetin, Glutamine, Andrographis, Ginger, Turmeric, and Black pepper for absorption. This combination of ingredients works together to support your overall health and well-being.
Vitamin A has been found to help strengthen the immune system by increasing white blood cell production which is important in fighting off infection or illness. Vitamin D3 helps with calcium absorption which also aids in keeping bones strong and healthy. B-6 helps with neurotransmitter production which can improve mood as well as energy levels. Magnesium helps reduce inflammation in the body while zinc helps with wound healing and boosting immunity. Copper supports collagen production for healthy skin and joints while alpha Lipoic acid provides anti-oxidant protection from free radicals in the body. Quercetin is an anti-inflammatory that can help reduce swelling associated with allergies or other illnesses while glutamine helps maintain healthy gut function. Andrographis is known for its powerful antiviral properties while ginger can reduce nausea and ginger has been used as an all natural remedy for centuries due to its many healing benefits such as reducing inflammation and aiding digestion. Finally black pepper helps increase the absorption rate of all these ingredients so you get the most out of each capsule.
What Are The Benefits Of Taking ZincMunity?
The combination of ingredients found in ZincMunity are designed to provide a wide range of benefits including supporting the immune system by providing essential vitamins and minerals necessary for optimal health as well as helping reduce inflammation which can lead to improved energy levels and better overall wellbeing. Additionally this product also helps keep bones strong thanks to its calcium absorption capabilities which may help prevent osteoporosis later in life as well as aid in wound healing due to its D3, Magnesium, & zinc content making it ideal for individuals looking for an easy way to get their daily dose of essential vitamins and minerals without having to take multiple supplements throughout the day.
Source Naturals Wellness ZincMunity 50 mg Bio-Aligned Zinc offers a comprehensive blend of vitamins, minerals, herbs that work together synergistically to support your immune system . Whether you’re looking for an easy way to get your daily dose of essential vitamins & minerals or just want something that will help boost your immunity , this product has something for everyone! With its unique blend of ingredients like vitamin A , vitamin D3 , B - 6 , magnesium , zinc , copper , alpha Lipoic acid , quercetin , glutamine , andrographis & more working together synergistically you are sure to see & feel the difference it makes! Give it a try today!
Glutathione: The Most Important Molecule You've Never Heard Of
October 22, 2022 10:17 AM
Glutathione is a small peptide molecule composed of three amino acids: cysteine, glutamic acid, and glycine. It is produced by every cell of the body, with especially high levels in the liver.* Glutathione is critical for healthy immune system function and is necessary for proper detoxification processes.* It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E.* Milk thistle extract and alpha Lipoic acid are included as complementary ingredients.
What does that mean for your health? In short, glutathione is one of the most important molecules for your overall health and wellness. Read on to learn more about this incredible molecule and how you can make sure you're getting enough of it.
Why You Need Glutathione
Your immune system is your first line of defense against illness and disease. Glutathione plays a critical role in immune system function, so making sure you have enough of it is crucial to maintaining your health. Glutathione is also necessary for proper detoxification processes. It helps your body eliminate toxins and other harmful substances. In addition, glutathione plays an important role in cellular health. It directly neutralizes free radicals, which can damage cells and lead to chronic diseases like cancer. Glutathione also helps keep vitamins C and E active, which are both important for cellular health. Milk thistle extract and alpha Lipoic acid are included as complementary ingredients to help support glutathione production.
Getting Enough Glutathione
You can get glutathione from certain foods, such as broccoli, cabbage, spinach, and garlic.* However, the best way to ensure you're getting enough glutathione is to take a supplement. supplements are the most bioavailable form of glutathione, which means they're better absorbed by the body.* Look for a supplement that contains all three amino acids (cysteine, glutamic acid, glycine) in a 2:1:1 ratio. You should also make sure that the supplement you choose includes milk thistle extract and alpha Lipoic acid as complementary ingredients.
Glutathione is a small but mighty molecule that plays a pivotal role in overall health and wellness. If you're not already taking a glutathione supplement, now is the time to start! Look for a supplement that contains all three amino acids in a 2:1:1 ratio, as well as milk thistle extract and alpha Lipoic acid. Your body will thank you for it!
Medical News Today: Alpha-lipoic acid: Everything you need to know
April 17, 2019 02:34 PM
Alpha-Lipoic Acid(also known as ALA) may be the next great discovery of how to affect health for the better on a cellular level. ALA is made in the center of a cell, in the mitochondria, and seems to help with weight loss, lessening the severity of diabetes, memory loss, cell degeneration and more. Since humans only make a small amount in their bodies, some supplements are available. However, there have been only limited studies on effectiveness and none at all for children.
"Since humans can only produce ALA in small amounts, many people turn to supplements to increase their intake."
Read more: https://www.medicalnewstoday.com/articles/323738.php
Alpha lipoic acid (ALA) treats back pain naturally: Research
April 13, 2019 11:15 AM
Studies of chronic pain sufferers that have been dealing with pain over a twelve week span have shown promising success by consuming alpha lipoic acid (ALA) supplements. By taking 600 mg per day, patients saw a large decrease in the amount of pain that they were suffering due to the consumption of the ALA pills. Researchers hope that the success of ALA in correlation to chronic lower back pain could give patients the opportunity to rely on more natural methods as opposed to opiates.
"If you suffer from chronic lower back pain, there is hope beyond a life of just taking pharmaceutical painkillers all the time to cope with the agony."
Read more: https://www.naturalnews.com/041571_alpha_lipoic_acid_back_pain_natural_treatment.html
Reduce your risk of developing an autoimmune disease withglutathione
November 21, 2018 12:15 PM
The 50 million Americans living with some kind of autoimmune disease share a deficiency of “master antioxidant” glutathione. Glutathione helps control and moderate the immune system, and reduce oxidative stress and inflammation, but lifestyle issues like lack of sleep, dietary factors, obesity and inadequate exercise can cause you to developed a glutathione deficiency. Supplements like N-acetyl-cysteine can help increase the amount of glutathione in your cells, while alpha-lipoic acid promotes recycling of oxidized glutathione. You can also address glutathione deficiency by eating a better diet and moderating your blood sugar.
"Research has shown that people with an autoimmune disease are always deficient in this antioxidant."
Read more: https://www.naturalnews.com/2018-10-24-glutathione-reduces-risk-for-autoimmune-disease.html
Did You Know Alpha Lipoic Acid Is the Best Antioxidant Out There?
November 18, 2013 07:58 AM
What is Alpha Lipoic Acid
The power of antioxidants has been being known since ancient times, primarily because these organic compounds can fight the potentially harmful substances from your organism named free radicals. Free radicals occur naturally within your body, but certain factors like pollution, improper nutrition or sedentariness can determine a substantial increase of their levels, leading to many severe diseases like cancer or diabetes. Alpha Lipoic acid is an organic compound mainly known as an essential fatty acid that is present in every cell of the organism; apart from being extremely beneficial for the brain’s functions, this compound has powerful antioxidant properties that help your organism eliminate the free radicals and prevent the oxidization of the living tissues.
Alpha Lipoic Acid as an AntioxidantAntioxidants are an important part of your organism’s immune system, because they create a protective barrier that can protect the organs from any potential disease; alpha Lipoic acid is considered the best antioxidant, because unlike vitamins which are either water or fat soluble, this fatty acid is both fat and water soluble, which means that it can recycle important antioxidants like vitamin C, so your organism can stay healthy for a longer time.
What are the Benefits of Alpha Lipoic Acid
Given that free radicals are strongly linked with an extensive variety of diseases and illnesses, as well as aging and mental disorders, the alpha Lipoic acid will benefit your organism all the way around, providing you with valuable properties that should never be neglected. Over the time, the levels of this fatty acid might decrease, so you will need to take supplements that contain it in order to supply its lack. Having proper levels of alpha Lipoic acid involves having a healthy brain, a young-looking skin and a well-functioning organism, so you need to make sure that your diet includes as many vitamins and minerals as possible, so you can enhance the powerful action of the alpha Lipoic acid and keep your organism completely healthy.
Health Benefits Of Taking L-Carnitine
November 04, 2013 07:18 PM
What is L –Carnitine
L –Carnitine is an amino acid that is naturally produced in the body. It is found in two different amino acids; methionine and lysine. Dietary sources of this amino acid include pork, beef and small amounts of milk, chicken and fish. This amino acid is highly required by the body and the following are the health benefits of Carnitine.
Important in the management of heart conditions
Carnitine is important in the management of a number of heart related conditions for example congestive heart failure, diphtheria, chronic chest pain, heart attack and high cholesterol. Studies show that Carnitine indeed is helpful in dealing with a number of heart related diseases.
Boosts overall brain function
A recent study shows that Carnitine aids in the recovery of stroke among animals. This clearly shows that this amino acid targets the brain cells. It contains nutrients that are highly required by the brain to function properly for example vitamins E, B-12 alpha-Lipoic acid and folic acid.
Helps in burning body fat
Carnitine is a portent fat burner. It is needed in the transportation of fat into cells which will be used for the production of energy in the body. When the Carnitine levels are increased in the body, the body increases the fat burning process and then boosts energy levels in the body.
This amino acid can prevent diabetes and promotes cardio vascular health. With its antioxidant properties Carnitine eliminates free radicals and also reduces oxidative stress. This is very important in the improvement of your insulin health and also help in fat loss.
Improves male fertility
Studies show that adequate Carnitine levels in the body are necessary for male fertility. According to the study fertile males had adequate levels of this amino acid it was associated with healthier sperm. While the others who were considered infertile had compromised sperm health and lower Carnitine levels.
Why Is Alpha Lipoic Acid The Best Antioxidant Supplement?
January 15, 2013 02:09 PM
Thiocitic acid, also called alpha Lipoic acid, is a natural antioxidant found in the body cells. It has been used by several people since 1950s for various purposes. It's a fatty acid that prevents oxidative destruction precipitated by free radicals and also aids in the breakdown of glucose to release energy. The health benefits of alpha Lipoic acid supplements are so many. Individuals suffering from diabetic neuropathy, premature skin aging and glaucoma can greatly benefit from the use of the antioxidant.
Water And Fat Soluble Antioxidant:
Thiocitic acid is soluble both in water and fats, therefore it reaches many parts of the cell to guard against free radical destruction. It's a potent antioxidant. Currently, these fatty acids are taken by many people in supplement forms. If you intend to use the antioxidant supplement, the following are some of the benefits of thiocitic acid.
This antioxidant is produced in the body and it can also be included in the diet; its use in the form of supplements is on the rise. When it is eaten in the form of supplement, it's converted into a very active form known as dihydroLipoic acid. It is also vital in the production of other antioxidants like vitamin C, vitamin E, and glutathione.
Both thioctic acid and glutathione assist in liver detoxification. It attaches to the toxins in the body and assist in their elimination from the bloodstream. It's also vital in promoting good health of the liver. Alpha Lipoic acid is also critical on the skin. It aids in cell regeneration and guards the skin against free radicals that precipitate aging of the skin. It assists in making the skin look younger and radiant. It may also help in decreasing wrinkles and fine lines. It is one of the most effective anti-aging supplements. It is sometimes called universal supplement. Benefits of thiocitic acid are not limited to skin, it's also vital in the treatment of conditions like neuropathy. Since it assists in changing glucose into energy, it can be important in losing weight.
Health Benefits of Alpha Lipoic Acid
July 02, 2012 07:53 AM
Alpha Lipoic Acid
Alpha Lipoic Acid, popularly abbreviated as ALA, can also be referred to as thioctic acid. It is an antioxidant as well as a fatty acid occurring naturally in the body. Every single cell in your body has this compound, which can also be sourced from food staff such as broccoli, spinach, organ meats, peas, brussel sprouts and rice bran. The following is a comprehensive list of the health benefits of ALA.
Health benefits of ALA on the aging process
ALA is known to delay the aging process. It does this through its antioxidant properties that help reduce cell damage, a condition that contributes to early aging of cells. This function also helps protect you from chronic illnesses that are attributed to old age.
Health benefits of ALA on brain cells
ALA also protects your brain from the damage caused by free radicals, thus protecting you from dementia and memory related problems. Studies conducted on animals have shown that this acid helps boost memory. Free radicals are also associated with brain cancer, and so this antioxidant helps protect you from developing malignant tumors in your brain. It also protects you from diseases such as Alzheimer.
Health benefits of ALA on blood sugar
Lipoic acid has been found to help regulate blood sugar thus helping relieve the symptoms of diabetes. It helps relieve the numbness, tingling, pain and itchiness experienced by diabetes patients. This function makes ALA an effective remedy for diabetes-related conditions such as peripheral neuropathy, cardiac autonomic neuropathy and autonomic neuropathy.
Health benefits of ALA on the skin
ALA has been used to manufacture a wide range of beauty creams because of its ability to improve the skin texture. This acid also protects the skin against sun damage, thus reducing chances of developing sunburns. It reduces the size of your skin pores thus helping correct specific types of acne. Finally, ALA helps improve the radiance of your skin thus giving you a beautiful and glowing skin.
Other health benefits of ALA
ALA plays almost all the roles of antioxidants, since it also helps boost your immunity. This function helps protect you from diseases such as:
• Multiple sclerosis
One of the advantages that ALA has over other antioxidants is that it is both water soluble and fat soluble, unlike the other antioxidants that are soluble in either water or fat only. Therefore, its health benefits can be felt all over your body. In addition, ALA is found in all cells within your body and so deficiencies are rare.
Even though ALA is synthesized naturally within your body cells, their production goes down as you age. This is why alpha Lipoic acid supplements are available. They are often presented in the form of capsules. There is no recommended daily dose of this supplement, but you need the guidance of a health physician in order to determine the right dosage for you. These supplements may cause serious reactions with specific drugs, and so your doctor will determine whether they are appropriate for you. Children are not allowed to take alpha lLipoic acid supplements because their bodies are still in a position to release enough for their needs.
Preventive Measures for Metabolic Syndrome/ Diabetes
February 10, 2012 07:55 AM
Metabolic syndrome is a serious health problem associated with cluster of conditions like high cholesterol level, high blood pressure, high sugar level and excessive fats in the abdomen. It increases risks of diabetes, heart attack and stroke. Having one of these conditions doesn't mean that you have metabolic syndrome. However, frequent occurrence of any of these symptoms can increase risk.
Knowing your family's medical history can prevent metabolic syndrome that can lead to diabetes. If it runs in the family, consult your doctor to have your blood sugar, cholesterol and blood pressure checked.
Avoid high carb diet to prevent metabolic syndrome and diabetes. During digestion, carbohydrate rich foods are broken down into sugar or glucose. Glucose gives energy to the body while calorie is the measure of burned energy. When high amount of carbohydrate is digested, it increases sugar level in the blood. The brain prompts the pancreas release insulin to neutralize blood sugar level. Diabetes happens when the body becomes resistant to insulin or when the pancreas does not produce enough insulin.
Replace high carb diet with more nutritious foods like oats, whole wheat, rye, red rice, sweet potatoes and buckwheat. They are energy giving food rich in dietary fibers. Fibers keep a healthy digestive system by improving digestion and eliminating body wastes. It maintains sexy abs by flushing out excess belly fats.
Stay physically active by engaging into sports and exercises. Inactive body does not use much energy. Unused energy is stored in the body in form of fats. Fat cells are resistant to insulin thus, increase blood sugar and cholesterol level. Fat cells slow down metabolism and increase weight gain. While lean muscles hastens metabolism even when the body is at rest. Lean muscle protects the body against insulin resistance.
Maintain a well balanced diet to reverse diabetes and metabolic syndrome. Raw fruits like oranges, berries, pineapple, grapes and other citrus fruits are good alternative for desserts like cakes. They are rich in Vitamin C that lowers cholesterol and burns fats. It is also rich in antioxidants that shield the body against harmful toxins.
Add green leafy vegetables to your diet to increase immunity from sickness like diabetes and metabolic syndrome. Green leafy vegetables are rich in Vitamin E that repairs and regenerates damaged cells.
Develop a healthy sleeping pattern. Sleep disturbances and staying up late at night prompt the pancreas to continually release insulin. This creates stress on the pancreas that leads to insufficient production of insulin. A well rested mind and body keep metabolic syndrome and diabetes away.
Try natural remedies like cinnamon, pine bark, and blueberry leaf extract. Cinnamon prevents diabetes and metabolic syndrome by lowering cholesterol and blood sugar level. Pine bark, when extracted produces pycnogenol that absorbs glucose in the blood. It also protects the eyes from blindness and blurred vision caused by diabetes. Blueberry leaf extract regulates blood sugar level by increasing the body's sensitivity to insulin.
Health supplements like chromium and alpha Lipoic acid have shown great results in preventing and managing diabetes. Chromium is a mineral that metabolizes carbohydrates to prevent weight gain. It stabilizes blood sugar and prevents hypertension.
What Are The Organic Compounds That Provide Our Brains With Their Basic Fuels?
October 12, 2011 01:58 PM
Brain health and nutrition has shown vast growth in interest in terms of research the past years and correctly so because the brain is a very important part of the body. This is something in my point of view that could never be replaced. Other organs like the heart, liver or kidneys can be transplanted or who knows in the far and distant future that it may even be replaceable. Well, I guess that may be just the sci-fi geek in me talking but seriously though, with the complexity in which the brain is made I do not think there will be any possibility even in the wildest of imaginations that humanity will be able to figure out a way to replace the brain.
The irony in all of this though is with human beings pushing the boundaries of their minds and manifesting the results through technological advancements all the more are we needing to protect our brains because life has become more complex. Things that were supposed to make life easier for us now seems to do the exact opposite and each technological advancement causes more and more Americans to have less and less time to devote to making sure they get the right nutrition through the right food preparation so the brain will have all the nutrients it needs. So with this we should look at how we can help augment our efforts in trying to keep our brain functioning healthily in a natural way.
Brain Health and Organic Compounds
There is a wide variety of organic compounds out there and too many of them to mention in this article in fact. Basically, organic compounds are compounds that contain carbon however not all are considered organic but that is irrelevant to what we are trying to achieve right now. So for brain health, the first organic compound that has proven to be very important is the vitamin family of rich antioxidant properties like Vitamin C and E as a couple of examples. Increasing antioxidant levels in the body through these vitamins is a very good way to reduce the risk of diseases and allow better protection for our brain against oxidative stress.
Not only that, it will also allow better health for our nerves and neurons which plays a big role in brain functions. Another example of a potent antioxidant to promote brain health is DHA and ALA or Alpha Lipoic Acid because it is able to get into the brain much easier compared to other antioxidants and fight free radicals there. Carnitine and choline are also essential contributors in modulating brain health as they are precursors to the production of acetylcholine which is an important neurotransmitter to aid in efficient neurological functions. And lastly but certainly not the least, ATP or adenosine triphosphate is also very important to brain function as this compound supplies energy to virtually all the cells in the body and any bodily processes that require energy to function efficiently needs ATP and that includes our entire nervous system.
Keeping your brain healthy is important especially since Alzheimer’s is an ever growing problem in the United States. Keeping your brain healthy with DHA, ALA, and vitamins is the right step for anybody who wants to take preventive measures and protect the brain.
Free Radicals And Cancer, How Do I Combat Free Radicals?
October 12, 2011 01:09 PM
Free Radicals Overview
Free radicals, just the very sound of those words are so dreaded in so many consultation clinics around the country today, this substance has mainly been linked to cancer and its proliferation but what else is there to know about free radicals and cancer. This is what we will be looking at as we go along this article. These free radicals are organic molecules which are primarily the cause for aging, damaged tissues, and a variety of diseases. The main property that causes them to bind with other molecules in the body there by causing damage is because it is unstable. This is the non-stop process that these molecules will do, destroy cells, takes away its vigor and initiate this pro aging process. In a way it is the natural order of things, our world is filled with so many unstable molecules and just like us, there survival instincts kick in and they have to keep stable. Outside the body, that’s all good, no harm for us, but when the same process occurs inside that’s where our own survival instincts come in and helps us think of ways to stop this process of degeneration. With this degeneration process of cells being damaged, it is not far fetch to see these free radicals as the cause of some disease most especially Cancer.
Cancer has been a close second as the top killing disease in America for the past few years now, 2011 is not over yet so there is no ranking out but my guess is, the top 2 will most likely be the same with number one still being heart disease. Cancer is basically characterized by out of control cell growth. There are many classifications of cancer and one thing remains constant, it is characterized or named based on what type of cells it began to damage to cause the eventual cancer. For many of us out there what we do not want to here are malignant tumors in the body and this can occur based on 2 things, when cancerous cells spreads around the body through the bloodstream which is often referred to as an invasion process and the second is when the cancerous cells divide and grow leaving tissues metastasized in a process called mestastasis. Tumors grow and uncontrollably which are lumps of masses that interfere with our normal bodily functions and causes systems to crash like our digestive and nervous systems just to name a few.
Antioxidants has been well known to be one of the best ways to fight cancer, present in many foods, these molecules does its handy work against cancer by going to the source. More research needs to be done in its healing effects but as an effective treatment it has been proven to be an integral part in minimizing further proliferation of damaged cells. Antioxidants have been shown to have an amazing characteristic against free radicals and that it plays an integral role in killing these cell damaging molecules in the body.
List of antioxidants:
This by far a complete list, but it will get you get started with an antioxidant program to help prevent disease caused by free radical damage.
Here are recommendations made by Dr. Oz.
September 22, 2011 12:47 PM
FYI - Here are recommendations made by Dr. Oz. See in blue the NOW Foods options.
1. Vitamin D:
- The only nutrient that's also a hormone
- 60% of Americans are deficient
- Helps immunity and cancers, especially colon cancer
- Take if not getting enough sleep
- 3 mg
- Take 2 hours before bedtime
- You should see a change in your sleep pattern within 1-2 weeks
3. Alpha Lipoic Acid
- Increases energy
- Slows the aging process
- Helps with diabetes that affects 80 million Americans
• 400 mg 3 times a day
• keeps immune system strong
• take as soon as symptoms develop
• fights respiratory infections
• NOW Foods Air Defense contains a patented form of Andrographis plus other lung supportive ingredients. a GREAT formula for seasonal health and the frequent traveler.
Can Alpha Lipoic Acid Help Lower Blood Sugar?
August 06, 2011 12:10 PM
Alpha Lipoic acid is a nutritional supplement best known as an antioxidant. It is an organic compound that plays many important physiological functions at the cellular level. For one, it is widely regarded as a potent scavenger of free radicals. It also affects the rate of metabolism and the production of energy. In fact, it has become one of the most popular supplements available in the past few years.
Often abbreviated as ALA, alpha Lipoic acid is a derivative of caprylic acid or octanoic acid. As its name suggests, caprylic acid is generally linked to goat milk, though it can be obtained from several other sources of food, such as vegetable oils. ALA has been the subject of studies in recent years. Apart from its role it in the prevention of oxidative stress, it also contributes to the regulation of blood sugar.
Modulates Insulin Function
Blood sugar is the concentration of glucose present in the bloodstream as measured by whole blood, plasma, or serum. Glucose is obtained from complex carbohydrates found in the human diet. It enters the circulatory system, travels through the bloodstream, and nourishes cells. It is the precursor of biochemical energy that supports the physiological functions of cells, tissues, and body organs.
There is good scientific evidence that alpha Lipoic acid influences the uptake of glucose. Insulin is the hormone responsible for regulating blood sugar levels as it instructs cells to take up glucose from the blood. It has been observed that alpha Lipoic acid induces the activation of insulin receptors, raises the number of glucose transports in cell membranes, and enhances glucose uptake in the process.
Increases Glucose Utilization
Alpha Lipoic acid is a dietary supplement popular among body builders largely owing to the fact that it increases glucose utilization. There is a growing body of scientific literature devoted to the effects of ALA on overall metabolic rate, the reason why it has been marketed as a weight loss supplement for years. As a general rule, glucose utilization by cells increases as the rate of metabolism increases.
The synthesis of adenosine triphosphate requires the presence of glucose, which the human body uses as a source of cellular energy. Numerous studies have reported that alpha Lipoic acid is capable of upregulating the production of energy in the form of adenosine triphosphate. Its presence triggers cells to convert glucose to energy at a faster rate, effectively affecting and lowering blood sugar.
Alleviates Diabetes Mellitus
Alpha Lipoic acid is especially helpful for people suffering from diabetes mellitus and its complications. In addition to its role in the management of blood sugar, it also protects the nervous system from cellular damage brought on by reactive oxygen species, as is the case with diabetic neuropathy. As a reputed free radical neutralizer, ALA not only alleviates diabetes but also prevents its complications.
Liver Protection With Lipoic Acid and R-Lipoic Acid
May 05, 2011 03:42 PM
Early biochemistry studies pioneered by Linus Pauling associated R-Lipoic acid with orthomolecular medicine in that proponents argued that it biological roles provide protection against diseases. Succeeding research in the latter half of the 20th century supported its status as an essential nutrient, but more recent studies proved that all it is produced in vivo by almost all mammals, including human beings. In the past few years Lipoic acid has been strongly linked to glutathione as its supplementation appears to raise levels of endogenous glutathione.
Strengthens Antioxidant Defense
Lipoic acid is believed to raise the antioxidant capacity of the human body. Its biological roles benefits all cells, most notably hepatocytes, the cells that make up a significant fraction of the liver. For one, it affects productions of glutathione throughout the body. Glutathione is tripeptide that protects cells from the damage caused by reactive oxygen species, such as free radicals. Furthermore, it is a major transport of toxins found in the systemic circulation, facilitating their excretion through the urine.
R-Lipoic acid has been observed to be the form of Lipoic acid that is capable of activating nuclear factor erythroid-derived-2-like 2, commonly abbreviated as NFE2L2, the protein that binds to DNA sequences responsible for regulating the antioxidant defense of the human body. Proponents believe that oral intake of R-Lipoic acid produces more visible results than its racemic counterparts.
Displays Higher Bioavailability
Research on Lipoic acid is one of the most advanced, starting in the 20th century and spanning over 5 decades. It is widely accepted that the forms available in the market are not bioequivalent. Most of the studies in the 1950’s utilize the enantiomer S-Lipoic acid and R/S-Lipoic acid race mixture because they were cheaper to produce. Recent developments in chiral chemistry have increasing allowed for large-scale productions of R-Lipoic acid.
Many scientists today believe that R-Lipoic acid is superior to racemic forms. Its rate and extent in availability after oral administration has been noted to be far better, and thus its efficacy is expected to be more remarkable. It is postulated that its higher bioavailability allows it to effective fill the roles of endogenous Lipoic acid, not to mention manage to influence the master regulator of antioxidants.
Shows Vitamin-like Properties
The popularity of R-Lipoic acid lies in vitamin-like properties. Researchers are particularly enthusiastic about its purported benefits on human health, though more studies are needed. It is one of the organic compounds needed for enzyme function just like vitamins, and supplementation is believed to produce preventative benefits against diseases. Its pervasive roles at the cellular level enable it to affect energy metabolism, leading to healthy weight loss.
Free Radicals and how to Combat Them!
November 30, 2010 02:41 PM
Vitamin C and E
Chances are you have heard about antioxidants. They’re everywhere: in the news, on the internet, and, of course, in our body. The first group of antioxidants that spurred the war against free radicals are Vitamin C and Vitamin E. As early as the 15th century, seafarers knowingly consumed citrus fruits in treatment of scurvy, which today we refer to as a disease caused by a deficiency of Vitamin C. On the other hand, intake of green leafy vegetables results in healthy cells in the body, touted lately as one of the benefits of Vitamin E. Since the latter half of the 20th century the term antioxidants have come into wide use, sparking a series of studies that led scientists and health professionals to a much more well-informed understanding of how important these vitamins are to human life.
Antioxidants and Free Radicals
Two things about biochemistry that have been a part of our growing concern about eating right are antioxidants and free radicals, which you might have learned outside the classroom. The human body deploy free radicals for the purpose of killing harmful microorganisms, but somehow these chemical entities get out of control. It should be noted that most known free radicals are short-lived, explaining how we survive as they are toxic to the body. When not properly disposed of, free radicals are one of the reactive oxygen species that create a chain reaction damaging everything, including DNA. The problem arises when the body fails to detoxify these reactive oxygen species, and then the latter run amok inside the body. This is when antioxidants come into the picture.
Vitamin C, Vitamin E, and Peroxyl Radicals
Vitamin C and Vitamin E are lipids that protect the interior of cells from the outside environment and play a role in storing energy for use by the human body. Different groups of lipids encompass several major chemical reactions in the body, including securing the proper functions of physiological communication lines. In a process called lipid peroxidation, peroxyl radicals go on a killing spree by depriving the lipids of electrons, which continues as they bring in more radicals. The human body make use of Vitamin C and Vitamin E to police the proliferation of lipid radicals in time to deactivate lipid radicals and avoid unwanted effects on cell membranes.
Ascorbate and Tocopherol as Co-Antioxidants
In chemical reactions, the body utilizes forms of tocopherol in Vitamin E and ascorbate ions in Vitamin C. These antioxidants work on the principle of pairing with peroxyl radicals, taking on radical forms, ascorbate and tocopherol, to stop the oxidation process initiated by free radicals. At the molecular level, ascorbate makes an ideal antioxidant as it does not react with oxygen and terminates harmful peroxyl radicals that continue to oxidize. Studies say that Vitamin C and Vitamin E are co-antioxidants in that ascorbate works with tocopherol. For example, when continuing oxidation damage lipids, tocopherol, Vitamin E, removes the harmful radicals, and ascorbate recycles Vitamin E back to its usable tocopherol form.
The Perfect Match
Alpha Lipoic Acid recycles both Vitamin C and Vitamin E because alpha Lipoic acid is both water and fat soluble.
Take Control Of your Inflammation With Supplements
May 27, 2010 12:40 PM
Chronic inflammation is often induced by uncontrolled oxidative stress (free radical damage). It is the principle mechanism by which degenerative disease takes hold. By reducing oxidative stress and changing the balance within the body to favor the production of anti-inflammatory chemical messengers, one can lower their levels of inflammation. This can be achieved through conscious changes to diet and lifestyle, which includes appropriate supplementation.
By consuming foods that are rich in omega-3 essential fatty acids, EPA, and DHA, derived from fish oil or flax seeds, one can greatly influence and reduce inflammation. When the body has appropriate balances of omega-3 and omega-6 essential fats, the production of anti-inflammatory prostaglandins is favored and inflammation is kept in check. Increasing the consumption of foods that are rich in omega-3s or supplementing with a high quality fish oil suppresses the formation of harmful prostaglandins and also promotes the synthesis of beneficial prostaglandins. Since the average North American diet contains 10 to 20 times the amount of omega-6 oils that we need, the most sensibly dietary approach is to reduce sources of omega-6 oils and supplement with a high dose of omega-3 oils in order to achieve the optimal 4:1 ratio of omega-6 to omega-3.
Supplementing with flaxseed oil is another effective way to optimize your omega-6 to omega-3 ratio. Anti-inflammatory EPA can be manufactured in the body by converting the alpha-linolenic acid that is often found in flaxseed oil. Supplementing with this oil, along with restricting omega-6 fatty acid intake, raises tissue EPA levels to those comparable to fish oil supplementation. It should even be noted that flaxseed oil contains more than twice the omega-3 fats as fish oil. Additionally, alpha-linolenic acid can be found in a variety of other plant source including pumpkin seeds, walnuts, and other nuts. However, flaxseed is by far the richest source of omega-3 oil, carrying 58% by weight.
Another nutrient that plays a crucial role in inflammation is gamma tocopherol. This nutrient acts through a mechanism that is unavailable to alpha tocopherol by reacting with RNO radicals to subdue inflammation. Gamma tocopherol also has the ability to reduce inflammation by inhibiting COX-2 , which is an enzyme that has a central role in the inflammatory process as it controls the synthesis of the inflammatory prostaglandin. The consuption of gamma tocopherol has been found to reduce several other inflammatory protagonists at the site of inflammation. Strong evidence has found that this form of vitamin E exhibits potent anti-inflammatory properties that are extremely important for human disease prevention and therapy.
Similar to essential fatty acids is resveratrol and green tea polyphenols each of which have the ability to inhibit the activation of NFkB and control a wide variety of inflammatory pathways. Green tea polyphenols are also believed to be neuroprotective, as they invoke a spectrum of cellular mechanisms such as the chelation of metals, scavenging of free radicals, and modulation of mitochondrial function in nerve tissues. Green tea polyphenols are now considered to be therapeutic agents that can alter brain processes and serve as neuroprotective agents in the progression of neurodegenerative disorders like Alzheimer’s and Parkinson’s disease.
There are a wide variety of nutrients that are involved in fighting systemic inflammation. These nutrients and nutrient categories include EPA and DHA, linolenic acid, gamma tocopherol, alpha-Lipoic acid, vitamin C, flavonoids, procyanidolic oligomers, and the phenolic compounds found in green tea, turmeric, and olive extracts. When changing your diet from saturated fats to unsaturated fats and adds more fruits and vegetables to their diet along with antioxidant vitamin supplements, one can successfully reduce inflammation naturally and live a healthier happier life.
Antioxidants and your health
May 17, 2010 10:44 AM
There is an impressive amount of scientific evidence supporting the health benefits of supplementing with a wide variety of antioxidants. Consequently, there are many health practitioners who have begun to recommend high dietary intakes of these crucial nutrients in order to prevent against oxidative stress. It was anticipated over two decades ago by leading researchers that high-dose supplementation with antioxidants is developing a significant role in the prevention and treatment of a lot of today’s common illnesses. It should be noted that antioxidants do not work in isolation. When an antioxidant neutralizes a free radical, it, itself, is oxidized and must be regenerated by another antioxidant before it can be used again. Because of this, it is crucial to supplement with a wide variety of antioxidants, in order to reflect what actually occurs in nature.
Vitamin C, an aqueous-phase antioxidant, is the main guard against oxidative attack in the extra-cellular matrix, as well as within the cytoplasm of the cell. Vitamin C happens to be a substrate for eight different enzyme systems that are involved in various cellular functions. Among these functions are collagen synthesis, ATP synthesis in the mitochondria, and hormone biosynthesis. Its main antioxidant partners are vitamin E and beta carotene, both of which help to regenerate vitamin C.
Of all the antioxidants, it seems as if vitamin E offers the greatest protection against heart disease because of its ability to protect the cardiovascular system from oxidative damage. It is lipid-soluble, making it an important component of the cell membrane, where it works to protect the cell against lipid peroxidation and control oxidation-induced inflammatory events. Recently, the gamma tocopherol form of vitamin E has shown a great deal of promise in its ability to reduce the risk of several oxidative stress related disease.
Beta-carotene is a member of a diverse group of photosynthetic pigments. It plays a huge role in human nutrition. As an antioxidant, it possesses a double-bond structure that allows it to react effectively with single oxygen radicals, absorbing and diffusing their energy. Beta-carotene also acts as a precursor for vitamin A by supplying a portion of the body’s requirement for the vitamin. This act alone plays a central role in the chemistry of vision. Beta-carotene and vitamin A both prevent the oxidation of cholesterol, reduce oxidative damage to DNA, and disable oxygen free radicals that are produced by exposure to sunlight and air pollution. These antioxidants are also involved in the activation of gene expression and the control of cell differentiation.
When combined together, vitamin C, vitamin E, and beta-carotene produce and important antioxidant trio that plays a huge role in fighting oxidative and inflammatory events. There are several other antioxidants that should be noted due to their ability to work synergistically with the vitamin C, vitamin E, and beta-carotene trio. These include vitamin A, alpha-Lipoic acid, lycopene, coenzyme Q10, and the antioxidant mineral, selenium. In order to determine whether a nutrient provides antioxidant support, scientists question whether the product contains vitamin C, vitamin E, vitamin A, beta-carotene, alpha-Lipoic acid, lycopene, coenzyme Q10, and selenium and to what strength these vitamins and minerals are per serving.
Protect The Liver with Glutathione And Cysteine
April 23, 2009 01:54 PM
The tripeptide L-glutathione is synthesized in the body from L. glutamic acid, L-cysteine and glycine, a reaction that can occur in any cell of the body although it is essential that it also occurs in the liver. Should glutathione concentrations drop, they can be increased by supplementing with cysteine or any other of the three amino acids that are used in the biosynthesis of this important if substance
The tripeptide exists in two forms: the reduced form (GSH) which contains a sulfhydryl (SH) functional group attached to the cysteinyl part of the molecule, and the oxidized form glutathione disulfide (GSSG). As electrons are lost from the reduced form, two molecules combine to create a dimer formed by a disulfide bridge, the process which can be reversed through reduction of the GSSG. Such electrons are lost during its reaction with free radicals, in which the free radicals are neutralized by the donation of an electron from the oxidized version of glutathione.
The definition of a free radical is a molecule that is lacking one electron from an electronic pair. Its prime purpose is then to steal an electron from the nearest molecule to it. In doing so, it can not only destroy that molecule, but also destroy body cells and lead, not only to premature aging, but also to some potentially fatal conditions.
It is an unusual peptide in that it involves a link between the cysteine amino grouping and the carboxyl functional group of the glutamic acid. It is a powerful antioxidant, acting as an effective free radical scavenger and protecting the body cells from the effects of free radical oxidation. However, it is on its detoxification effect in the liver that we shall focus here prior to discussing some other uses to which the body puts glutathione in its two manifestations.
Much of the detoxification is connected with the thiol group in the molecule. Take mercury for example. The thiol grouping forms a strong Hg-sulfydryl chemical bond within the liver, in the form of a glutathione-mercury chelate. In this form mercury is unable to exert any toxic effect on the body and can be excreted in the normal manner. The same reactive pathway is followed by other heavy metals that can bond to thiol groupings. In this way L-glutathione can protect the liver from the effects of a number of toxic heavy metals such as cadmium and chromium.
This is an important property of the amino acid, particularly in industrial and urban environments where the population is more prone to exposure to heavy metals than their rural counterparts. However, the end result on the glutathione is that it is removed from the body, and, particularly with city dwellers, a supplement may be required to maintain a healthy concentration of this amino acid in the body and in particular in the liver. Therefore, although L-glutathione is not considered an essential amino acid, in that it is biosynthesized within the body, a supplement is sometimes required, particularly by those who live in large cities.
It is important to consider the form in which the glutathione supplement is administered. This is because of the presence of gamma-glutamyltranspeptidase within the digestive system. This enzyme appears to destroy L-glutathione before it can be absorbed in the intestine so normal oral forms of supplementation are likely to be ineffective. Possible forms of effective administration include buccal (between the cheek and teeth) and hypodermically.
An alternative means of supplementation is to take substances such as selenium, methionine, alpha-Lipoic acid, vitamin C and glutamine that stimulate the biosynthesis of glutathione. Also, since the substance utilizes the raw materials of L-cysteine, glutamic acid and glycine in its intracellular production, supplementation with these amino acids should also help to produce L-glutathione.
That said, let's return to its antioxidant properties and its effect on the liver that contains the largest stocks of glutathione in the body. It is generally regarded as the most important antioxidant in the body. It protects cellular cytoplasm from oxidation by reducing disulfide groups and maintaining a highly reducing environment within the cytoplasm. It reacts with hydrogen peroxide and other oxidative agents, and is converted to the oxidized form GSSG. It is then reduced back to GSH through the combination of the reducing agent and an enzyme. The reducing agent is nicotinamide adenine dinucleotide phosphate (NADPH), the enzyme being glutathione reductase.
The implications that this strong reducing effect has on the liver are significant. Reduced GSH L-glutathione levels have been found in patients suffering from HIV, hepatitis C and other liver diseases. Supplementation with GSH has been found to restore normal levels of glutathione to the liver, and it has been demonstrated that the treatment has improved such conditions significantly.
Atherosclerosis is a condition of the arteries caused by the deposition of plaques formed from oxidized low-density lipoproteins, otherwise known as bad cholesterol. The strong antioxidant effect of GSH prevents this from LDLs from being oxidized and deposited on the arterial wall. There are other results of glutathione supplementation that indicate the effectiveness of antioxidants in the treatment of serious liver conditions, and there are no doubts that combating the effects of free radicals and oxidizing agents within the liver has a positive effect on many potentially serious liver diseases.
Many of these are exacerbated by the generation of free radicals by relatively modern pollution sources such as pesticides, petrol and diesel emissions, tobacco fumes and various other chemical emissions. A strong antioxidant such as L-glutathione cannot be anything other than an effective means of reducing the biological effect of these oxidants. It protects not only the liver but also the lungs and cardiovascular system.
For all these reasons a supplement consisting of L-glutathione or its constituent parts, glutamic acid, cysteine and glycine, provide significant protection against the stresses and strains of modern living. Increased pollution levels and heightened oxidative stress levels within the body are playing havoc with our body defenses, and GSH is an important one of them that can easily be enhanced by supplementation. There are no known reactions to L-glutathione supplementation, but pregnant women and babies should receive expert medical advice prior to taking it.
Glaucoma (loose your eye sight)
February 16, 2009 01:18 PM
Glaucoma is a group of diseases that affect the optic nerve and can lead to irreversible vision loss. It is usually associated with elevated fluid pressure within the eye. All forms of glaucoma can cause damage to the optic nerve and lead to vision loss, even blindness, if left untreated. About 2.2 million Americans have been diagnosed with glaucoma and as many as 2 million more could have it and not yet know. It is one of the lading causes of blindness and is expected to become more prevalent in years to come due to the growing population of older adults.
Those people who are at greatest risk for developing glaucoma are people over the age of sixty, people of African ancestry, and people with diabetes, high blood pressure, severe myopia, or a family history of glaucoma. Smokers also have an elevated risk, as do those who have sustained eye injuries or who have used steroids for an extended period of time.
About 3 percent of Americans are believed to have open-angle glaucoma, which is the most common form of this disease. Because this disorder causes no symptoms until it is quite advanced, only about half of those who have it are actually aware of it. In open-angle glaucoma, there is no physical blockage and the structure of the eye appear to be normal. However, the drainage of fluid is inadequate to keep the intraocular pressure at a normal level.
The most pronounced symptoms of open-angle glaucoma are the gradual loss or darkening of peripheral vision and a marked decrease in night vision or the ability of the eye to adjust to darkness. Other possible symptoms include chronic low-grade headaches, the need for frequent changes in eyeglass prescription, and/or seeing halos around electric lights.
A far less common, yet more serious, form of glaucoma is closed-angle glaucoma. Closed-angle glaucoma is much more dangerous than open-angle forms because it almost never manifests any symptoms until very late in the condition. By that time, vision may be irreversibly damaged.
Glaucoma probably has many causes, with many scientists believing it may be closely linked to stress and nutritional problems or disorders like diabetes and high blood pressure. Some think that excessive amounts of glutamic acid, which is a nonessential amino acid, may be involved. Glaucoma has also been linked to deficiency in nitric oxide, which is a molecule that is critical for healthy blood vessels. Problems with collagen, the most abundant protein in the human body, have been linked to glaucoma as well. Collagen increases the strength and elasticity of tissues in the body, especially those of the eye. Collagen and tissue abnormalities at the back of the eye contribute to the clogging of the tissues through which the intraocular fluid normally drains. This results in elevated inner eye pressure, leading to glaucoma and related vision loss.
The following nutrients are considered to be very important when dealing with and preventing glaucoma: choline, essential fatty acids, glutathione, rutin, vitamin A, vitamin B complex, vitamin C with bioflavonoids, vitamin E, alpha-Lipoic acid, magnesium, a multivitamin and mineral complex, and zinc. Additionally, the following herbs are helpful: bilberry, chickweed, eyebright, coleus forskohli, fennel tea, chamomile, ginkgo biloba, zinc sulfate, jaborandi, and rose hips.
To resolve issues with the eyes, one must change their diet, exercise, and take supplements and herbs like what are listed above. Medical doctors are at a loss as to how glaucoma happens but they can help stop the progression of this disease if detected early on. Always consult your doctor before adding vitamins and herbs to your diet, vitamins and herbs are available at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
Alpha Lipoic Acid
December 11, 2008 11:19 AM
Alpha Lipoic acid is the ideal antioxidant for five main reasons. It can scavenge free radicals of all kinds of both fat and water-based cell structures. It rapidly assimilates and absorbs into cells. Alpha Lipoic acid boosts the action of other protective compounds. It chelates free meal ions and it also promotes normal cell replication.
Alpha Lipoic acid (ALA) is both fat and water soluble, which makes it a superior free-radical scavenger because it can protect lipid (fat) and aqueous (water) cell parts from free-radical damage. This ability allows ALA to offer excellent cellular protection because it can easily transport across cell membranes and give oxidant protection outside and inside cell structures. ALA has the ability to freely move throughout all cell parts, scavenging for free radicals in a way that is definitely more effective than other antioxidant compounds. Vitamin C, for example, is a good antioxidant but is strictly water soluble and only affects the interior of cells. On the other hand, vitamin E is only fat soluble, meaning that it affects only the lipid portion of cell structures or the membrane, which leaves other areas unprotected.
Cellular glutathione, which is produced in the body and works to neutralize free radicals, is very difficult to artificially boost. Although oral glutathione supplements are available, they have to go through the GI route before they enter the blood stream, leaving little glutathione which actually survives this process. Because of this, cellular levels are not significantly increase by oral supplementation. ALA has been found to help regenerate glutathione by providing extra cellular protection.
If the body becomes deficient in ALA, other antioxidant compounds may not work well. ALA plays an important role in boosting the activity of protective compounds such as vitamin E. ALA dramatically extends the life and effectiveness of other vital compounds.
ALA has been used for decades to treat diabetic conditions and complications including diabetic neuropathy, with ALA actually having the ability to initiate a reverse in the condition in some cases. Additionally, ALA helps to boost glucose uptake and results in less insulin dependency in some cases. Among its other properties, ALA can protect brain tissue on a cellular level, as well as protect brain cells from certain hazardous chemicals.
Research has shown that ALA may even play a role in the treatment of neurological disorders such as Huntington’s disease. As we are all aware, LDL cholesterol has a huge role in the development of cardiovascular disease. LDL cholesterol, which is particularly susceptible to free-radical damage, can be protected by ALA from free radical damage itself. Along with the above properties, ALA has been shown to help in strokes, cancer, cataracts, HIV, liver regeneration, and detoxification.
ALA can be purchased in tablet and capsule form and works well when it is orally ingested so that it can be easily assimilated through the walls of the gastrointestinal tract. Taking between 40 to 50 mg of ALA is recommended for best results. The primary applications of alpha Lipoic acid are aging, aids, alcoholism, atherosclerosis, bell’s palsy, cataracts, cancer, cirrhosis, diabetes, diabetic neuropathy, multiple sclerosis, liver disease, radiation sickness or exposure, Alzheimer’s disease, senile dementia, stroke, Huntington’s disease, Parkinson’s disease, and heavy-metal poisoning. Have you had your alpha Lipoic acid today?
Green Coffee Bean Extract
October 22, 2008 04:59 PM
It is known that aging is largely a result of the effect of free radicals on our body cells, and that green coffee bean extract can be used to fight against these. While we intuitively understand what the term ‘aging’ means, very few people can actually describe it in words, although there are several theories of why it occurs.
The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition.
However, by far the most acceptable and best understood theory is the Free Radical Theory of Aging, which green coffee beans have been found to help fight, and it is on that which we shall focus here.
The Free Radical Theory of Aging
Free radicals are oxidants created by unpaired electrons. Electrons generally go around in pairs, but occasionally molecules lose one of these electrons, creating a situation where it possesses an unpaired electron. In this condition, that molecule has only one purpose in life and that is to oxidize other molecules by stealing an electron from them.
Oxidation can cause untold damage to cell membranes, and also to other molecules that are vital to life, such as DNA. The end result is aging, and the onset of many diseases and conditions connected with aging. Free radicals are believed to be behind inflammatory diseases such as arthritis and Crohn’s disease, strokes, cardiovascular disease, Parkinson’s disease, Alzheimer’s disease and cancer among many others. Each of these is associated with aging.
Free radicals are generated in the body in four different ways:
1. Energy is generated by the intercellular mitochondria by the production of ATP (adenosine triphosphate). By-products of the mechanism by which this is done include hydrogen peroxide, the superoxide anion, and a hydroxyl radical. Over 20 billion molecules of antioxidant are produced in each individual cell daily, and every one of these has the capability to do damage to your body. The figure for inefficient cell metabolism is significantly higher.
2. Peroxisomes are eukaryotic cell components that contain oxidative enzymes, whose function is to produce hydrogen peroxide that is then used by another enzyme, catalase, to oxidize other toxic substances. It is used by the liver, for example, to oxidize about a quarter of all the alcohol we drink to acetaldehyde, and also to remove other toxins from the body. The down side is that the hydrogen peroxide can escape and degrade the cell membranes.
3. Chronic infections give rise to a high activity of white blood cells, which utilize oxidants of various kinds to destroy viruses, bacteria and parasites. These include hydrogen peroxide, superoxide and nitric oxide which can also destroy the cells they are protecting.
4. Cytochrome P450 is an enzyme used to clear the body of toxic chemicals in our food such as pesticides and drugs. They also give rise to oxidative by-products.
In addition to these, free radicals are also produced by air pollution consisting of smoking, factory emissions and traffic fumes. Trace metals such as lead, iron and copper, are rich free radical sources, as is the ultraviolet component of sunlight, and caffeine, from tea and coffee, can also contribute to the store of free radicals in your body.
So where does green coffee extract come into this, and how should it be used. Free radicals tend to react very rapidly to accelerate aging, and in order to counter them, and hold the effects of aging at bay, it is necessary to destroy them almost as quickly as they are produced. This is carried out by antioxidants, of which there must be a plentiful supply available in each body cell.
Antioxidants donate electrons to free radicals, and so effectively neutralize them before they can attack the membranes of the cells in your body, or any of the other tissues that they can degrade. Many of the vitamins have a powerful antioxidant effect, among them vitamins A, C and E. Other antioxidants available in our diet include beta carotene and other carotenoids, flavonoids and glutathione, and also cofactors such as Lipoic acid. All of these can destroy free radicals by the donation of an electron.
Green coffee beans have also been found to possess a strong antioxidant effect, due largely to the plant phenols, such as caffeic acid that forms chlorogenic acid with quinic acid, both cholorgenic and caffeic acid being string antioxidants. Green coffee bean extract is standardized to 99% chlorogenic acid. This substances not only reacts rapidly with free oxygen radicals but also helps to prevent to formation of hydroxyl radicals.
It has been established that green coffee bean reacts twice as fast as green tea or grape seed extracts, and speed of reaction is critical in the destruction of free radicals that have to be destroyed before they do damage. Other antioxidants found in extracts of green coffee beans include heterocyclic compounds such as pyrroles, furans and maltol.
The extract is made from beans of Coffea Arabica, this containing higher concentrations of chlorogenic and caffeic acids than the Arabica plant. The extract is also produced to be naturally low in caffeine, thus avoiding the negative effects of drinking coffee for its stimulating properties. When the green coffee bean is roasted, the antioxidant effect is found to decrease, and after roasting and brewing both the Arabica and the Robusta beans have reduced in activity to much the same level.
Studies on some of the conditions exacerbated by free radicals have indicated the effectiveness of green coffee beans as an antioxidant. It is believed to help reduce atherosclerosis caused by the oxidation of low density lipids (LDL). Oxidized LDLs tend to be easily absorbed by phagocytes to form plaques and foam cells in artery walls, thus narrowing and hardening the arteries, causing a deprivation of oxygen and nutrients to the heart and also increased blood pressure. Antioxidants from the green coffee bean prevent this from happening, and so help to reduce this serious effect of aging.
A good supply of antioxidants will also prevent the cell membranes from being destroyed, one effect of which is to age the skin. Antioxidants in the form of green coffee bean extract can help to maintain a youthful appearance while also aiding in the prevention of the more serious effects of free radicals that can shorten life.
There are no doubts that free radicals contribute significantly to accelerated aging, and that the antioxidants contained in green coffee beans can help hold back the physical signs of aging, while also helping to destroy those free radicals that threaten life by promoting cancer, atherosclerosis, and other similar conditions.
Lower Blood Sugar
October 16, 2008 01:54 PM
Many people struggle to control their weight. However, while they are going on and off various diets, they fail to realize that they are also struggling to control blood sugar. Actually, the cause of blood-sugar problems may be weight problems, as being overweight and having blood sugar problems tend to go hand in hand. Too many blood sugar swings during the day tend to increase hunger jags, snacking, and overeating. When you overeat, you’re much more likely to add on the pounds, setting the stage for obesity, pre-diabetes, and full blown diabetes.
Sadly, both pre-diabetes and overweight have become modern epidemics that are out of control, with two of every three Americans being overweight and over 100 million people having some signs of pre-diabetes. Both of these illnesses are nutritional disorders that result from eating too many unhealthful foods. However, there is good news: you can reverse pre-diabetes and control your weight.
One can self-diagnose pre-diabetes by looking for the most visible symptom: being chubby or fat around the waist. Other clues are cravings sweets and starchy foods, not being hungry at breakfast, and feeling tired or mentally fuzzy after lunch. Many physicians diagnose pre-diabetes when a patient’s fasting blood sugar falls between 100 and 124 mg/dl. There are several dietary factors that significantly increase the risk of overweight. Some of these being: too many calories, too many refined carbs, especially sugars, and too many unhealthful oils.
The average woman needs about 1,600 calories and the typical man needs about 2,000 calories daily, but the average American now consumes 3,900 calories each day, making it difficult to burn off all these calories and causing the accumulation of body fat. Because most excess calories take form of refined carbs and sugars, which are digested rapidly, rapid or extreme spikes in blood sugar levels, elevated insulin levels, and bouts of hunger result, which stimulate low blood sugar. Trans fats, which are found in partially hydrogenated vegetable oils, interfere with the body’s processing of fats and often lead to weight gain. Most of these problematic calories are found in fast foods, microwave foods, and other types of convenience foods, which are all best if they are avoided.
Even though pre-diabetes can be scary, it’s actually an opportunity to improve your eating habits and regain your health. To improve your health you can emphasize quality protein, emphasize high-fiber vegetables and fruits, include grapefruit in your diet, use more vinegar, and add some cinnamon. Since protein stabilizes and safely lowers blood sugar levels, be sure to start each day with some protein with breakfast and eat a little protein with each meal.
Most veggies and fruits are rich in fiber, which helps to lower blood sugar, so opt for salads and steamed broccoli while avoiding crutons, potatoes, bananas, and pears. Despite the calories, eating fresh grapefruit can help in weight reduction. The acetic acid in vinegar can also help to improve blood sugar and insulin levels, reduce appetite, and help with weight loss. Adding cinnamon has also been shown to reduce blood sugar levels. There are also several supplements that have exceptional value in improving insulin function or lowering blood sugar levels. These include Lipoic acid, chromium, silymarin, omega-3 fish oils, vitamin D, and Pycnogenol.
You can also enhance the benefits of diet and supplements by increasing your physical activity as it helps build muscle and burn blood sugar and fat. Tackling pre-diabetes can not only reduce your long-term risk for health problems, such as heart disease and Alzheimer’s disease, but also can allow you to quickly gain more energy and feel less post-meal fatigue.
What is Alpha Lipoic Acid?
July 18, 2008 12:36 PM
You can be sure that a supplement has some remarkable therapeutic possibilities when it makes headlines on the five o’clock news. A recent experiment which showed the conditions of rats that had been fed a diet that was totally deficient in vitamin E tested alpha Lipoic acid, which caused the rats to return to full health even though no vitamin E was replenished. The results of this test are profound, as giving these rats an alpha Lipoic acid caused existing stores of vitamin E that the body was previously unable to use to be regenerated.
Alpha Lipoic acid is a vitamin-like antioxidant that has been used in Europe for a long period of time. It has recently emerged as an extremely impressive therapeutic agent that scavenges free-radicals. Recent studies have suggested that it has the ability to stop some degenerative diseases, the oxidative process of aging, and restores the health of diseased organs. Additionally, it has the ability to make up deficits of vitamin E or C and could potentially be one of the best treatments that have emerged for diabetes. Alpha Lipoic acid (ALA) is considered to be more potent than vitamins E and C, as well as coenzyme Q10. Unlike other antioxidants, ALA has properties that make it superior because it is able to replace certain nutritional supplements, while potentiating others, and inhibiting tissues from deterioration that is associated with diseases. This supplement is also both fat and water soluble, which allows it to protect lipid and aqueous cell structures.
Alpha Lipoic acid is a compound that is synthesized in small amounts in the body, but can also be supplied from food or supplement sources. A vitamin-like substance, it contains sulfur and also plays a crucial role in energy reactions. It can be found in liver, yeast, spinach, organ meats, broccoli, red potatoes, and red meat. When it is orally ingested, alpha Lipoic acid is not compromised in the GI tract or the liver.
Numerous studies have been conducted on ALA, all of which confirm its positive effect on metabolic processes, with recent clinical tests supporting its ability to enhance free-radical protection, slow the aging process, and guard against a variety of degenerative diseases. ALA was discovered in the 1930s, where it was originally classified as a vitamin, and later categorized as an essential coenzyme when scientists discovered that it was involved in the energy processes of cell mitochondria. It wasn’t until 1988 that scientists found that it also has powerful antioxidant effects.
Alpha Lipoic acid is important because it protects us from free-radicals which are present in a body as a result of the number of toxic substances such as auto exhaust, tobacco smoke, pollution, preservatives, and additives that we are exposed to on a daily basis. These free radicals can actually accelerate the aging process, causing premature tissue breakdown to occur. Additionally, our environment will continue to surround us with these pollutants that create free radicals.
There are things we can do to minimize our health risks, which include exercising, eating nutritiously, and not smoking. However, these measures are rarely enough to decrease our risk for certain degenerative disease a substantial amount. ALA is beneficial because it scavenges oxidants that are left behind and helps to convert carbohydrates, fatty acids and protein to energy that is needed to drive muscle movements.
April 08, 2008 08:41 PM
A unique blend of compounds, including alpha-Lipoic acid, N-acetyl cysteine, quercetin, and grape seed extract, which is designed to reactivate and recycle vitamin C in the body, making it more available for immune support and free radical scavenging.
The well-known benefits of vitamin C are recharged in this formula, which is designed to make more vitamin C available for immune support and free radical scavenging. The unique blend of compounds in systemic C may reactivate and recycle vitamin C in the body, providing increased antioxidant activity for healthy aging, heart health and immune support.
Vitamin C (as calcium ascorbate) 1 g
Systemic C - Vitamin C with Optimized Vitamin C Activity!
March 28, 2008 04:22 PM
What could be even better than vitamin C? source naturals systemic C, of course, a vitamin C that is designed to upgrade the important benefits of this powerful antioxidant. The systemic C formula is designed to make more vitamin C available for immune support and free radical scavenging.
After vitamin C carries out its antioxidant function of neutralizing free radicals, it is oxidized and spent. The unique blend of compounds in systemic C, including alpha Lipoic acid, n-acetyl cysteine, quercetin, and grape seed extract, helps to reactivate and recycle vitamin C in the body. this provides the body with increased antioxidant activity, an upgraded, robust C for healthy aging, immune, heart, and skin health. Reactivating vitamin C allows this important vitamin to continue its vital functions.
Alpha Lipoic Acid is a Powerful Antioxidant
February 15, 2008 02:55 PM
The discovery of alpha Lipoic acid at the University Of Texas Chemistry Department in 1951 was not heralded with trumpets of joy at the revelation of such a powerful antioxidant, but was instead largely ignored. This is largely due to the biochemistry involved not being fully understood at that time, but by the 1980s it was a commonly used supplement, recommended for several medical conditions.
Chemically, the substance is a 5-membered cyclic disulphide with a carboxylic acid grouping. Biochemically, it’s extremely powerful antioxidant properties are largely due to the fact that it one of those rare active molecules that are soluble in both water and fats, and in fact is the only such antioxidant currently know. One of the properties that this ability enables it to possess is to cross the blood-brain barrier, and apply antioxidant propertied to the brain.
Antioxidants are essential to human life in that they destroy free radicals. These are compounds with free unpaired electrons that destroy human body cells in their hunt for electrons to pair with. Electrons come in pairs in organic animal tissue, just as they do in organic compounds. However, under certain circumstances this pairing can become destroyed, leaving a molecule with one of its electrons without a partner.
The factors that lead to this situation are many and varied, and our own biochemistry can produce free radicals during the normal chemical processes of life. However, pollution can also lead to the oxidation processes that create free radicals, common such pollutants being cigarette smoke, vehicle exhaust fumes, pesticides and the like. Excessive exposure to the UV content of sunlight can also create free radicals as can eating barbecued and smoked foods, and exposure to carbon monoxide and peroxides. Even the biochemical conversion of glucose to energy in our bodies creates free radicals.
These free radicals can destroy body cells, including DNA, and can create conditions such as premature aging due to destruction of skin cells, destruction of brain cells, strokes, cancers, diabetes, atherosclerosis due to oxidation of LDL cholesterol that deposits in the main arteries of the body, stiffening of the joints and many other undesirable conditions.
Free radicals are destroyed rapidly by antioxidants: the reaction is very rapid and most are destroyed immediately they are formed before they can do harm. Fortunately, if your diet is well maintained, the body possesses many antioxidants such as vitamins A, C and E, and other substances such as Coenzyme Q10, flavanoids, xanthenes, polyphenols and carotenoids. Many of these are found in highly colored foods, and if your food is brightly colored, it should contain a good supply of antioxidants.
However, the problem with all of these is that they are either fat and oil soluble or water soluble, which means that they can either be freely carried round the body by the blood or have to be emulsified by the bile and transported via the lymphatic system that places restrictions on their effectiveness in certain organs of the body. The fact that alpha Lipoic acid is soluble in both water and fats enables it to be carried to all parts of the body and to every organ, and can cross water/fat barriers that other antioxidants cannot do.
It can therefore be carried via the blood to the brain and carry out an essential antioxidant function within our brains. It took a long time for this property of ALA to be recognized and its consequent health benefits understood. It is, in fact, the ideal antioxidant. The substance provides many known benefits to the body due to its antioxidant properties and also helps the body to generate the maximum possible amount of energy from the blood glucose and thus improve the energy balance of your body.
However, it is with its antioxidant properties that we are most concerned here. One of the benefits of these properties is its effect in holding back the visible effects of aging on your body. Because it is both water and fat soluble, alpha Lipoic acid can help destroy free radicals in every part of your skin; the areas served by the blood and the fatty and oily secretions are protected simultaneously by the same strong antioxidant. The end result is a reduction in the destruction of the cells through the dermis and epidermis and a reduction in the degree of wrinkling with age.
Its antioxidant effect in the brain renders ALA in great demand for reducing cognitive impairment with age. In fact studies have indicated that alpha Lipoic acid can improve memory and brain function in the aging and the elderly. This effect appears to be increased by the synergistic combination of alpha Lipoic acid and acetyl-L-carnitine that work together to prevent cognitive decline in the brain through the effect of free radicals.
There is evidence that during a stroke, ALA works synergistically with vitamin E to reduce the effect of free radical damage on the vulnerable brain cells, and so reduce the longer term effects of the stroke. Together with ALC, it also reduces oxidative stress on the mitochondria of cells and in so doing helps once again to reduce the effects of aging, and maintain the body’s capacity to generate energy from blood glucose.
Cardiovascular disease is the main killer of the western world, largely due to our diets, and this is especially true of the USA. Although Americans appear unable to change their unhealthy diet, alpha Lipoic acid and acetyl-L-carnitine can be used to offset much of the damage done. ALA reduces the development of atherosclerosis through its antioxidant properties and the reduction of the adhesion of monocytes to the artery walls.
LDL trapped in the wall of the artery can be oxidized and enable monocytes to also enter under the surface of the arterial wall, where it changes into macrophages and ingests the oxidised LDL, causing the plaque that forms atherosclerosis. As the plaque thickens, the artery becomes increasingly restricted until the blood flow is significantly reduced or even stopped, causing cardiac failure or a stroke.
Alpha Lipoic acid can prevent this free radical oxidation from occurring by destroying them before they act on the low density lipoprotein (LDL). Acetyl-L-carnitine works with the ALA to achieve this, as does another substance known as carnosine. Between them, these three musketeers work to keep your arteries clear and your brain functioning as it should, though it is the ALA that is most powerful due to its oil and water solubility properties.
Although alpha Lipoic acid is available as a supplement, either alone or in combination with acetyl-l-carnitine, it is also available from natural food sources. It is particularly rich in offal such as heart and kidney, and also in broccoli, spinach and brewer’s yeast. It is also available in beef, and it is here that burgers can perhaps repay some of the damage that it causes. However, it is not a recommended source since burgers still cause more damage to your health than any of their constituent nutrients can allay.
Like any other supplement, you should seek medical advice before taking any substance if you have a health condition. Nevertheless, the benefits of alpha Lipoic acid are such that it is difficult to see it doing anything but good. However, please consult your physician if are taking other drugs.
L-Glutathione Can Eliminate Toxins in the Liver
December 07, 2007 11:54 AM
L-glutathione is the reduced form of glutathione, and is a tripeptide synthesized in the animal and plant tissues from glycine, cysteine and glutamate. Commonly known as GSH, it contains thiol groups that are maintained in a reduced state, and is a very powerful antioxidant, considered to be the key antioxidant and protective substance in the body.
Glutathione can reduce any disulfide groups in the cytoplasm within the body of the cell, and ensures that the cytoplasm is a strongly reducing medium protecting against oxidation. It has a synergistic effect with other antioxidants to protect the body against free radicals and oxidizing agents that cause so much damage to the body through what is commonly referred to as ‘oxidative stress’. However, there is more to it than that and it attaches itself to toxic chemicals and drugs in the liver and renders them into a state suitable for elimination from the body.
These toxic materials include poisonous pesticides, hydrogen sulfide, carbon monoxide, heavy metals such as mercury, cadmium and chromium and many other substances that we come into contact with due to present day pollution of our atmosphere and foodstuffs. Glutathione can also help protect the body from the effects of chemotherapy and evidence is suggesting possible links with the control of some cancers, diabetes, atherosclerosis and many other degenerative conditions caused by free radical attack and the effects of pollutants.
The way that GSH acts in the cells is that the redox state of the glutathione-glutathione disulfide couple is critical to the health of the intercellular and intracellular fluid. GSH in the reduced state of glutathione reacts with an oxidative agent such as hydrogen peroxide to form the oxidized form, glutathione disulfide and water. It hence mops up oxidizers such as peroxides and free radicals within the cytoplasm of the body’s cells, and also in between the cells. The disulfide is then converted back to GSH by the combined action of the enzyme glutathione reductase and NADPH (the reducing agent nicotinamide adenine dinucleotide phosphate).
The cycle then repeats so that two molecules of glutathione continue to reduce damaging oxidizing agents without themselves being consumed. In so doing, the NADPH becomes oxidized. A continuous supply of NADPH is needed to allow GSH to undergo these biochemical reactions, and up to 10% of our blood glucose is used by the pentose phosphate pathway by which NADPH is synthesized.
Since this cycle consumes no glutathione, it would appear that a supplement is unnecessary. However, this is not the case since the molecule takes part in other reactions in the body, particularly in the elimination of toxic heavy metals from the body. Mercury is highly reactive with the thiol that GSH is, and so will bind to form a stable Hg-sulfydryl bond in the liver. This mercury-glutathione chelate is unable to bind to other proteins or gain access to the body cells, and is eventually harmlessly secreted. The same is true of many other heavy metals that are reactive with thiol’s.
In this way the body is protected from the harmful effects of these heavy metals. However, it results in the loss of the glutathione, and the pollution of modern day living can take a heavy toll of the GSH content of our bodies. For this reason a glutathione supplement is recommended, especially for city dwellers that may be exposed to more heavy metals than those residing in rural areas.
However, the form in which this supplement is taken is very important, because the human digestive tract contains a significant amount of gamma-glutamyltranspeptidase. That is an enzyme which apparently destroys glutathione before it can be absorbed. However, it can be absorbed directly into the bloodstream by dissolving the pill between the teeth and inner cheek. It has also been suggestion that the supplement could be administered by injection.
Others have suggested that rather than administer a supplement, individuals could take other supplements that contain the materials needed to stimulate the formation of GSH. Substances such as vitamin C, selenium (important in GSH biochemistry), methionine, alpha-Lipoic acid and glutamine could all help to increase the body’s production of glutathione. A supplement of the constituent parts of cysteine, glycine and glutamic acid should also help. The dosage ranges recommended vary widely from 50mg to 500mg daily, and the effects of supplementation are not yet well know.
Some specific conditions that this wonder antioxidant is useful in treating include liver disease such as hepatitis, cirrhosis and so on. Patients suffering from these diseases show a massive reduction in their GSH content and prior GSH treatment appeared to offer a significant degree of protection in controlled clinical investigations. Patients suffering from chronic hepatitis C have been found to be associated with reduced GSH levels, particularly if also HIV positive.
Similar deficiencies have been noted in some lung conditions such as asthma and other pulmonary conditions. In such cases it has been demonstrated that administration of GSH supplements sufficient to restore normal levels of the substance improved the patients’ conditions by a significant amount. Its effect on atherosclerosis appears to be significant since a decreased level of GSH peroxidase has been recorded in such patients in addition to an increase in lipid peroxides, indicating that oxidation of the arterial wall had been occurring.
Anti-viral therapies that rely on GSH biochemistry for their action have been found to be less effective in those with low GSH levels, and other studies have confirmed that supplementing with GSH improves the response to interferon treatment. These results indicate the activity of oxidizing agents and free radicals in liver conditions, and in fact this has been demonstrated by tests carried out in New York and Philadelphia in the 1990s.
This suggests that the liver is prone to damage by oxidative stress, and that GSH levels may be able to be used as an indication of potential liver disease. What is evident is that a strong case can be made for glutathione supplementation as protection against potential liver, pulmonary and cardiovascular diseases, especially by those exposed to specific polluting agents such as primary or secondary tobacco smoke, auto and diesel fumes and chemicals and pesticides.
L-glutathione is useful, not only for the elimination of toxins in the liver, but also in protecting this large and vital organ from the oxidative stress that modern living brings. L-Glutathione and its precursors are sold over the counter at your local or internet health food store.
Memory And Focus
May 08, 2007 02:05 PM
Memory & Focus
Some people think getting older often means getting slower. It’s true that as we age, we may find we can’t walk quite as fast, climb as many flights of stairs, or play sports as hard as we could when we were twenty. However, we k now that a healthy diet, regular exercise, and the right dietary supplements can make a huge difference in our health, strength, and mobility as we age.
This is true for our mental abilities as well. We may not think as quickly as we used to, might misplace our keys more often, and experience more “tip-of-my-tongue” word searches. These so-called “middle-aged moments” most often have minor consequences: a missed appointment or the forgotten name of an acquaintance. However, in a small number of cases, these mental slips can also be the first sign of serious diseases of aging, such as Alzheimer’s disease of other dementias.
The good news is, just like our physical health, we can improve how we function mentally. Eating healthy foods, taking the right supplements, and participating in regular mental exercise can significantly increase our mental endurance, improve our memory, and optimize our ability to focus.
In fact, groundbreaking and ongoing research has discovered that specific herbs and vitamins, particularly Ginkgo Biloba, Bacopa monnieri, folic acid, vitamins B6 and B12, and the important co-enzyme and antioxidant, alpha Lipoic acid, all have powerful effects on memory and focus. These nutritional supplements have been scientifically shown to quickly reduce mild age-related memory chances, as well as greatly reducing the risk of developing more serious problems like Alzheimer’s disease, Parkinson’s disease, or other brain diseases later on in life.
Q. What is the difference between age related memory decline and dementia?
A. As we get older, our nerve cells need more time to spark and connect, slowing the process of bringing memories and events to mind. Another theory is that, as we age, we accumulate more knowledge and memories. The mind then has to sort through much more data to reference a memory. Almost everyone middle-aged and older notices this slowdown. Memory decline and problems with mental focus are a normal part of aging.
While it’s true that the older we get, our chances of developing Alzheimer’s disease increase, this illness is not a normal part of aging. Alzheimer’s is an irreversible, progressive dementia that slowly kills nerve cells in areas of the brain where memory, learning, though, and language take place. Often first appearing as people begin retirement, Alzheimer’s disease makes the “golden years” a time of loss and devastation. Memories vanish, relationships are erased, and independence is gradually lost.
After Alzheimer’s disease, the second most common cause of dementia in older people is multi-infarct dementia. Caused by a series of mini-strokes that damage or destroy brain tissue over time, multi-infarct dementia usually affects people between the ages of 60 and 75. Men are slightly more at risk. High blood pressure is the most significant risk factor for multi-infarct dementia.
Multiple sclerosis, Parkinson’s disease, strokes, Huntington’s disease, Creutzfelt-Jakob disease, and alcoholism can also cause progressive and irreversible dementia.
While normal age-related memory and focus loss may mean we can’t remember where we put our car keys, Alzheimer’s disease and other dementia may mean we can’t remember what our car keys are used for.
Q. Are any types of memory and focus loss reversible?
A. Yes. As women enter menopause, they frequently experience trouble remembering. This memory interference is caused by hormone fluctuations and can affect speech, thinking, and attention. Symptoms of menopause-related memory loss and poor focus include recognizing faces less well than in the past, missing scheduled appointments, and misplacing articles. Once a woman passes through menopause, her ability to remember and focus most often improves.
Certain medications, such as the heavily prescribed cholesterol lowering drugs called stains, can temporarily interfere with memory. Low vitamin B levels, artherosclerosis (hardening of the arteries), and thyroid disease can cause disruption of mental focus and memory loss. These problems usually resolve with treatment of the underlying disorder.
A certain type of stoke, called a transient ischemic attack (TIA) can cause memory loss that may be reversible. A TIA is a brief episode of stroke symptoms that come on quickly. Sometimes referred to as a “mini-stroke” or “warning stroke,” a TIA is caused by a temporary interruption in the blood supply to the brain. But, unlike a stroke, a TIA does not lead to permanent brain damage. While a TIA is usually short-lived, it is likely to occur again if not properly managed and can be a warning of future stroke.
Q. I seem to forget a lot of things. How can I be sure I don’t have Alzheimer’s disease or some other dementia?
A. If you, or other around you, are concerned about your memory, you should be examined by your health care practitioner. Once the cause of your memory and focus problem is diagnosed, treatment can begin. All causes of memory loss and mental focus disruption can be treated, even Alzheimer’s disease. While presently irreversible dementias cannot be cured, the progression of the disease may be slowed, and in some cases, stopped..
Research on memory loss and mental focus disruption has increased dramatically in the past few years. Discoveries regarding Alzheimer’s disease and other dementias, as well as age-related loss of memory and focus have recently been made. Most importantly, many new treatment options, including the use of nutritional supplements, have been developed.
Q. How can nutritional supplements improve memory and focus?
A. Several herbs and vitamins have been demonstrated to improve memory and mental focus. While some nutritional supplements work now to improve memory and focus, others work to prevent problems we might develop later.
One of the most researched herbs, Ginkgo biloba, has been found to be effective in improving currently experienced memory and focus loss; in other words, problems we are having now. Ginkgo has been studied in individuals who have age-related memory loss, as well as in those with Alzheimer’s disease and other dementias. It seems that ginkgo can improve many brain functions, such as speeding up memory recall, protecting brain cells from chemical changes and free radical damage, improving blood flow to the brain, and helping nerve cells communicate with each other better.
Several studies examined ginkgo’s effect in healthy people who were experiencing normal age-related memory and focus problems. They determined that ginkgo improved memory, attention, and clarity of thinking. Ginkgo can also help restore memories that may be lost in TIAs, those mini-strokes that were discussed earlier.
In studies of individuals with Alzheimer’s disease, the results showed that ginkgo slowed down the disease in those severely afflicted and actually improved those with very mild or moderate disease. In one of these studies, ginkgo was compared to four prescription cholinesterase inhibitors, medications commonly used to treat individuals with Alzheimer’s disease. Using written mental tests, the researchers found that ginkgo worked just as effectively as the prescription drugs. While those taking one of the cholinesterase inhibitors dropped out of the study because of disturbing side effects, ginkgo had no side effects and improved symptoms equally as well.
Q. Hoe does Bacopa monnieri help memory and focus?
A. Like ginkgo, bacopa works on the memory and focus problems we are experiencing now. Bacopa grows in
Q. How does alpha Lipoic acid help memory and focus?
A. Alpha Lipoic acid (
Researchers have discovered unmistakable free radical damage in Alzheimer’s disease. Accordingly,
In a recent study, people with Alzheimer’s disease were given tests that measured through and memory. They were then given
Q. How do vitamins B12 and B6 help memory and focus?
A. Vitamin B6 is an essential nutrient in the regulation of nerve transmissions. It is required by the nervous system for normal brain function, and it may also help with mood.
Researchers have learned that people with Alzheimer’s and other dementias (including Parkinson’s disease) have elevated homocysteine levels. IN fact, t he amount of homocysteine in the blood corresponds to the severity of the disease. Most people with a high homocysteine level don’t have enough folate, vitamin B5 or vitamin B12 in their diet. Replacing these vitamins helps return the homocysteine level to normal.
Reducing homocysteine levels may prevent the occurrence of Alzheimer’s disease, or other brain diseases, and improve the symptoms of those already afflicted.
Q. What about folic acid?
A. Folic acid has long been recognized as a vital nutrient for the brain and spinal cord. Recent research has demonstrated that folic acid has significant importance in Alzheimer’s disease.
An ongoing study of Alzheimer’s disease that began in 1986 has been studying 678 members of the School Sisters of Notre Dame in the hopes of learning how the disease develops, how it might be prevented, and how to treat it. Data collected in the study includes biographies the sisters wrote upon entrance to the order, blood samples from the sisters while they are living, and information gained from the voluntary donation of their brains after death.
Aptly named the “Nun Study,” ground breaking discoveries have already been made. It seems that diet and nutrition have a dramatic influence in the development of Alzheimer’s disease. Sisters who had high levels of folic acid showed little evidence of Alzheimer’s-type damage in their brains after death. And, those nuns who had Alzheimer’s disease in spite of high folic acid levels had profoundly less brain damage from the disease. In fact, some sisters who had no outward evidence of Alzheimer’s disease while they were living had surprisingly extensive damage in their brains after death.
Q. Besides taking ginkgo, bacopa, B vitamins, folic acid, and ALA, is there other things I can do to prevent Alzheimer’s disease?
A. You may not know if you have a serious B-vitamin deficiency. Routine lab work does not measure the amount of B vitamins in your blood. You might want to ask your health care practitioner to have your B vitamin level in your blood measured, especially if you are having memory and focus problems. Keep in mind that this type of lab work is fairly expensive, however.
Supplements do not replace the need for a healthy diet, especially a diet with high levels of fruits, vegetables, whole grains and omega-3 fatty acids. Keeping your body healthy helps keep your brain healthy as well.
It also seems that the use-it-or-lose-it theory applies to our brain as well as our body. Research has shown that people who seek opportunities to keep mentally active, such as reading books, newspapers, and magazines, solving crossword puzzles, playing card games, and visiting museums, lower their risk of Alzheimer’s disease.
Dealing with age-related memory loss may be both frustrating and frightening. As the population of
In fact, more and more research shows prevention of Alzheimer’s disease and other dementias is a reality. And age-related memory loss can successfully be improved as well. Taking the scientifically validated nutritional supplements ginkgo, bacopa, vitamins B6 and B12, folic acid, and
Scientific Method of Evaluating the Effectiveness of Natural Medicines
April 21, 2007 01:57 PM
Author Dale Ericsson, M.D.; Shinian Cao, M.D.; Fred Crawford, Ph.D; Dale Haufrect, M.D. and Tommy E Hall, Jr.; USA
It has been traditionally assumed that long chain mucopolysaccharide and other natural ingredients found in aloe vera are active only in aloe vera are active only in their unadorned and non-modified state. There is little scientific evidence, however, to support this conclusion. In fact, certain isolated components of aloe vera have pronounced specific pharmaco-therapeutic effects. The purpose of this series of experiments is to evaluate this unique method of scientifically evaluating biological and herbal products and to specifically compare fractionally distilled aloe preparation from a traditional ale preparation.
Utilizing the scientific method of white blood cell (T lymphocyte) culture, stimulation and metabolic turnover rates of more than 25 substances it was determined that:
1. the pivotal study had demonstrated that this type of T lymphocyte cell culture metabolic analysis is useful for evaluation the safety and efficacy of a variety of treatments in which there is only antidotal or clinical studies to support the therapeutic effect.
2. This technique of single blinded study has been employed to define the efficacy as well as compare fractionally distilled aloe vera (warren Aloe) and a traditional aloe vera product. Application of this type of blinded study to two different forms of aloe vera showed that the following conclusion may be expressed with certainty.
This data suggest that the fractionally distilled Aloe vera is bio-pharmaceutically active and provides specific changes in T cell cultures when compared to baseline and with natural aloe vera juice.
This information has been condensed. For entire report refer to EXPLORER! For the processional magazine; volume thirteen: number Two: Pages 15-19.
Hyaluronic Acid Double Strength 100mg – w/ Proline, Alpha Lipoic Acid & GrapeSeed extract.
April 04, 2007 09:38 AM
Hyaluronic Acid has emerged as one of the most significant anti-aging supplements in the natural products industry. As a mucopolysaccharide that occurs naturally within the human body, the highest concentrations of Hyaluronic Acid are found in the skin, eyes, and articular cartilage. Hyaluronic acid works by absorbing water within the body, which in turn supports the formation of effectiveness of the gel-like matrix that protects healthy cell structures from dehydration and free radical damage. Ongoing studies continue to suggest that it may help support some of the body’s most vital functions.*
Strong, Healthy Joints
At birth and well into our youth, the human body produces ample amounts of Hyaluronic acid. These levels decline, however, based on our physical activity levels, dietary habits, and other hereditary and environmental factors. Hyaluronic acid is a key component of synovial fluid and cartilage, and serves as one of the body’s most vital natural lubricants. Joint structures lack blood vessels, and there for relay on Hyaluronic acid to transport fluids and nutrients. Many structural and articular challenges have been traced back to insufficient Hyaluronic levels.
Wrinkles and Fine Lines
Healthy, wrinkle-free skin requires a constant supply of water. Without enough, dermal cells located deep below the skin’s surface can becomes deprived of the compounds they need, thus leaving the skin dry and dehydrated. Hyaluronic acid attracts and binds large amounts of water at the cellular level to ensure that the skin has everything it needs to remain smooth, elastic, and youthful-looking.
Some published reports suggest that a child’s ability to produce abundant amounts of Hyaluronic acid may explain why they heal so quickly, often without permanent scarring. Because of the many roles it plays within the body’s connective and epidermal tissues, Hyaluronic acid is becoming more and more accepted as a way to help encourage the body’s natural wound-healing processes.
Vision and Eye Health
In addition to cartilage and synovial fluid, the eyes contain some of the body’s highest concentrations of Hyaluronic acid. In fact, the vitreous humor (the Eye’s Core) is made up almost entirely of Hyaluronic acid. This gel-like structure absorbs shock, supports vision, and protects the retina from being damaged. It is believed that many common vision and ocular problems may be a result of poor Hyaluronic acid production during adulthood.*
Each Vcap contains 100mg of Hyaluronic acid, along with Alpha Lipoic Acid, standardized Grape Seed Extract, and pharmaceutical grade L-Proline for support. Compare Now’s 100mg formula to some 50mg formulas that do not include supporting antioxidants for the same price, and the choice is clear!
For Better Heart Health ...
February 06, 2007 12:57 PM
Nutrients Every Heart Needs
High blood pressure. High cholesterol levels. Ever increasing stress. All are factors related to the development of heart disease – the leading cause of death for both men and women. In fact, 1 in 2 women in the
Fortunately, heart disease is a problem you can do something about. Proven ways to prevent or mitigate the effects of heart disease include taking targeted nutritional supplements, making changes in the foods we eat, exercising most days of the week, drinking in moderation, eliminating tobacco use and adapting a positive attitude. Research shows that those of us who are often angry and depressed have more heart disease than people that live their lives with a more positive outlook.
In this Ask the Doctor, we’ll talk about specific nutritional supplements that are heart healthy, whether your goal is to prevent heart disease or reduce the effects of heart disease if you currently have it.
Q. I am trying hard to live a healthier life. But it all seems so overwhelming. How do I start?
A. It may help to know that you’re not alone in feeling overwhelmed. Lots of people feel this way. This is why the Centers for Disease Control and the American Heart Association are both urging people to prevent heart disease by identifying their individual health risk factors.
A risk factor is an indicator of whether or not you may develop a certain health condition. In heart disease prevention, there are two kinds of risk factors. There are risk factor you can control – such as diet, exercise, and the supplements you take. There are also risk factors you can’t change or control –your age, race, and gender, as well as your family’s history of heart disease.
Examples can be really helpful. Let’s follow three adults – Fred, Jane, and Earl – and determine their risk factors.
Fred is 32, single, has a job he loves, has an optimistic attitude about his life, and works out 5 days a week. Most days Fred’s diet is fruits, vegetables, whole grains and low fat. Occasionally Fred will eat a cheeseburger and fries when he watches the game with his buddies. Fred’s risk factors are his male gender and the occasional high fat content in his diet.
Jane is 55, a lawyer, married, and has a very stressful job. Jane eats lots of salads, fruits, and whole grains. However, her job requires her to work long hours which leaves little time to exercise. Jane is for the most part happy with her life, but her work stress had led to times of negativity. Her father had a heart attack when he was 56. Jane’s risk factors include her age (greater than 50), negativity from job stress, lack of regular exercise, and a family history of heart disease.
Earl is 65, married, and has just retired from a job he hated. He spends most of his day watching TV and eating potato chips and other high fat, salty snacks. Earl has told his friends and family since he worked so hard for so long, he is sure to drop dead soon after retiring. He has high cholesterol and high blood pressure. Earl’s father had a heart attack and died when he was 73. Earl’s risk is his male gender, age (greater than 50), sedentary lifestyle, poor diet, negative outlook on life, high cholesterol and high blood pressure, and a family history of heart disease.
Q. OK, it’s pretty easy to see that Fred needs to watch his diet, Jane needs to exercise more, and Earl needs lots of help. But, which supplements should they take?
A. The Whole Heart Nutrition chart is an easy way to determine the supplements each risk level needs. As you can see, everyone wanting to prevent heart disease – Fred, Jane, Earl, you, and I – need to take quality heart formula multivitamin, garlic, and a fish oil supplement providing Omega-3 fatty acids. CoQ10 is also a smart choice for complete heart heath support.
Q. Why do we all need to take a “heart multivitamin”? Why can’t we take a regular multivitamin to prevent heart disease?
A. Since the human heart simply cannot function without adequate amounts of certain vitamins and minerals, it seems logical that a multivitamin would be the foundation of good nutrition for your heart. Heart-health formulated multivitamins provide the exact nutrients needed to prevent heart disease.
That’s why we need to take a specially formulated heart-focused multi-vitamin. The cells and the tissues that make up the heart must have vitamins C, A, and E, as well as B1, B6, and B12 to function. Folic acid, the little B vitamin that is so crucial in preventing spina bifida (a birth defect), breast cancer, and Alzheimer’s disease is also needed to keep heart muscles strong. The B vitamins and folic acid are very important to heart health because they help lower homocysteine levels. Homocysteine is a potential and emerging cardiac risk factor,
Magnesium is a mighty mineral and healthy hearts need it every day. Aloha Lipoic acid, a fatty acid, provides protection against heart cholesterol and high blood pressure. Lutein and lycopene are all-natural nutrients and keep our arteries free from the buildup of plaque, a condition linked to heart attacks and strokes.
Multivitamins formulated with these exact vitamins, minerals, and nutrients will work with medications often prescribed to treat heart disease and provide the nutrition our hearts need.
Q. Don’t all multivitamins work with medications prescribed to treat heart disease?
A. Many multivitamin formulas contain herbs and other nutrients that can interfere with prescription medications, especially mediations prescribed to treat heart disease. One multivitamin does not fit all.
The more risk factors you have, the greater your chance of developing heart disease.
Q. What can garlic supplements do for Fred, Jane and Earl or other people with low to high risk factors?
A. Garlic supplements have a very long and very successful history of preventing premature death from heart attacks. Lately, however, there have been some conflicting news stories about supplemental garlic’s ability to lower high cholesterol and high blood pressure – the causes of heart disease and death. That’s because many different garlic supplements have been used in these studies – garlic oil, garlic powder, aged garlic extract, and supplements made from fresh garlic. They have all been studied clinically for their effects in heart disease.
The best garlic supplements (and the ones that showed the best effects in garlic studies) contain alliin, which is then converted to allicin. Allicin is the compound that lowers harmfully high cholesterol levels and dangerous blood pressure readings. Allicin is also responsible for garlic’s characteristic odor. Because alliin is very stable when dry, properly prepared and enteric coated fresh garlic preparations preserve the allicin-producing action until the garlic mixes with the fluids of the intestinal tract. Fresh garlic extract’s enteric coating also prevents garlic breath. In contrast, aged garlic contains absolutely no allicin or allicin potential. This fact is probably responsible for the poor results noted in lowering cholesterol and blood pressure from aged garlic preparations.
The most effective garlic supplements are made from fresh garlic, enteric coated, and provide a daily dose of at least 10 milligrams (mg) alliin or a total allicin potential of 4,000 micrograms (mcg). Taking a once-daily garlic supplement that delivers 4,000 mcg of allicin will lower Jane’s and Earl’s high blood pressure and Earl’s high cholesterol, naturally and effectively.
Whole Heart Nutrition
Each additional risk factor requires additional supplements or increased doses for protection from heart disease.
Q. What about fish oil supplements? I know they can prevent heart disease but I’ve also heard they contain harmful substances, too.
A. You’re right on both counts. But, there are excellent fish oil supplements naturally loaded with Omega-3 fatty acids, powerful nutrients that prevent heart disease, that are also certified free of harmful contaminants.
In the 1980s, researchers first began noticing the native Inuit (Eskimo) populations of Greenland and
Research has shown that the Omega-3 fatty acids in fish oil supplements can:
-Reduce the risk of arrhythmias, lethal heartbeat rhythms that cause sudden death.
-Lower the levels of triglycerides, fats in the blood that can increase a person’s
risk of dying from a heart attack, even if a person’s cholesterol levels are normal.
-Slow atherosclerosis – the growth of harmful plaque on artery walls.
Atherosclerosis develops over many years. If the plaque growth is slow and
stable, chances are low that a heart attack will result. However, rapidly growing
or unstable plaques can rupture. The body responds with inflammation, which
causes blood clots to form. These blood clots block the artery and cause a heart
-Keep blood pressure levels low. Many people have high blood pressure for years
without knowing it. That’s because it has no symptoms. Uncontrolled high
blood pressure can lead to stroke, heart attack, heart failure, and kidney failure.
While 25% of Americans have high blood pressure, nearly one-third of these
people don’t know they have it. This is why high blood pressure is often called
the “silent killer.”
You can get all of this heart disease preventive protection from just 600-1800 mg of fish oil. It’s pretty simple to see why Fred, Jane, Earl, and you and I need to take fish oil supplements every day.
However, it is absolutely critical that the fish oil supplement you take is free of contaminants and guaranteed fresh! Make sure that the manufacturer of the fish oil supplement you buy is able to provide documentation of purity in their product. Supplements should contain no detectable dioxin (a widely used toxic preservative), DDT (a toxic insecticide), PCBs (polychlorinated biphenyls) or heavy metals such as mercury and lead.
Before you buy any fish oil supplement, ask the clerk if you can open the bottle or jar and smell the contents. A fishy smelling fish oil supplementation means it is rancid. Rancid fish oil is not going to help your heart at all and may actually hurt it.
Q. That leaves CoQ10. Why is it important for Jane and Earl?
A. CoQ10, also known as ubiquinone, is the premier heart supplement! CoQ10 is part of our energy producing system. It works directly in the mitochondria of each cell. Mitochondria are highly specialized structures within each cell and are often referred to as powerhouses. These tiny energy producers generate 95% of the energy the body requires. The number of mitochondria in a cell depends on its function and energy needs. The heart has very important functions and requires a vast amount of energy. Thus, the heart has a lot of mitochondria or little powerhouses.
CoQ10 is incredibly crucial to the health of our hearts. Especially to hearts that are pumping blood with too much cholesterol. But, in a dangerous paradox, CoQ10 levels can become dangerously depleted when physicians treat high cholesterol in their patients with certain medications. The so-called “statin” drugs (Mevacor/lovastatin and Crestor/rosubastatin are two examples) are powerful and medications prescribed to lower harmful cholesterol levels. However, one very harmful side effect they share is that they deprive cells of CoQ10. While some physicians are aware of this serious side effect and tell their patients to take at least 400 mg of CoQ10 each day, most are not. The result? Any good the statin drugs may be doing is actually negated by their depletion of CoQ10.
Q. How does CoQ10 actually work? Has it been studied in heart disease?
A. Yes, it has! CoQ10 has been extensively studied in heart disease. This natural nutrient is present in every nucleated cell in our body (the only cells that don’t contain CoQ10 are red blood cells). Heart cells, however, are absolutely loaded with CoQ10. Its job is fairly simply – CoQ10 is vital to the production of adenosine triphosphate (ATP), the compound our body uses for 95% of its energy needs.
In 1998, 144 patients who had been admitted to the hospital after a heart attack, participated in a CoQ10 study. Half of the patients received 120 mg of CoQ10 a day in addition to the usual treatments given to heart attack patients. The other half, the control group, received the usual treatments and a placebo, but no CoQ10.
The results showed that the group taking CoQ10 had less irregular heartbeat, experienced less angina (a type of heart pain), and had much better function in the left ventricle (the most essential chamber of the heart), compared to the placebo group. Total deaths due to sudden heart failure or another heart attack were also reduced in the CoQ10 group.
Q. What if I have already been diagnosed with Congestive Heart Failure? Will CoQ10 still help me?
A. CoQ10 has been proven in study after study to help slow down the destruction that occurs in congestive heart failure (CHF), a serious heart disease, and heal the heart muscles damaged by heart attacks. In fact, heart attacks often occur when the body’s CoQ10 levels are low.
In a CHF study, patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the researchers introduced a catheter into the right ventricle of the patients’ hearts to determine the degree of muscle damage CHF had caused. In the group who took CoQ10, the pumping ability of the heart improved significantly. The placebo group’s hearts did not. The researchers conducting the study recommended that people with CHF add CoQ10 to the other medications they need to take to stay alive and well.
Q. Are some types of CoQ10 better than others?
A. Indeed they are. CoQ10 products are not created equally. The key to this natural medicine is the quality of the manufacturing. Take a CoQ10 supplement that’s been used in research conducted by prestigious universities (it will tell you this right on the label). Researchers want the best CoQ10 for their studies. You want the best CoQ10 for yourself and your loved ones.
The best CoQ10 has to meet the following criteria:
1. Must be easily absorbed during the digestion process so that it can get into the
2. Must reach the mitochondria in the cell.
3. Must be proven effective in studies.
4. Must be safe and free of impurities.
Q. It sounds as if CoQ10 is only for people with moderate or high risk factors. Can others benefit from this supplement?
A. Many people, including those like Fred with low risk factors or no risk of heart disease take CoQ10 every day. CoQ10 supplements may reduce your risk of cancer, prevent gum disease, and help certain nerve cells work more effectively.
Understanding your personal risk factors, making it better lifestyle choices, taking a multivitamin formulated for your heart, an enteric-coated fresh garlic supplement, fish oil supplement with Omega-3 fatty acids, and CoQ10 – the heart’s super-nutrient – can help keep your heart healthy and strong.
Helen Keller, the famous lecturer and author, who was both blind and deaf wrote, “The best and most beautiful things in the world cannot e seen or even touched. They must be felt with the human heart.”
Healthy hearts have the most opportunities to “feel” the best and are the most beautiful thing our world has to offer.
Taming the Tingle – ALA helps fight nerve damage caused by diabetes…and more.
November 09, 2006 01:27 PM
For some people the constant tingling in their feet is the worst part. Others feel like their feet are being stabbed or burned, or that their extremities are simply lifeless. All these folks suffer from peripheral neuropathy, nerve damage that afflicts nearly 30% of people with diabetes aged 40 and older. And if the discomforting sensations are not enough, neuropathy can lead to falls, wounds that won’t heal, even amputation.
Untold numbers of individuals have been helped by alpha Lipoic acid (ALA), a supplement that European practitioners have used as a standard neuropathy treatment for 30 years. ALA (also known as thioctic acid) assists in the chemical reaction that generates energy within cells. It serves as a universal antioxidant—a substance that can fight tissue-damaging free radicals in both the fatty watery parts of a cell-and helps the body create additional free radical fighters, such as glutathione. ALA can even help regenerate several other antioxidants, including coenzyme Q10 (CoQ10) and vitamins C and E.
People with diabetes need antioxidant protection as much as anyone. Fortunately for them, though, ALA fights this insidious disorder in many other ways.
Diabetes occurs when the body can no longer effectively use glucose (blood sugar), its main energy sources; ALA helps shepherd glucose out of the blood and into cells. It also interferes with glycosylation, a process in which glucose sticks to proteins such as the low-density lipoprotein (LDL) that carries cholesterol through the bloodstream. That’s important because this “sticky” LDL can adhere to arterial walls, creating a major risk factor for heart disease. ALA combined with exercise appears to make insulin, the hormone that controls glucose usage, more effective. What’s more, early research indicates that ALA can deflect another cardio hazard by interfering with the ability of salt to push blood pressure upward (molecular and Cellular Biology 12/03).
ALA Annotations – what is it? Alpha Lipoic acid, a substance the body creates naturally.
What it Does: ALA, a powerful antioxidant in its own right, plays a vital role in the creation and renewal of other antioxidants. It is used to treat peripheral neuropathy; nerve damage caused by diabetes, and is also under investigation for possible therapeutic effects in other disorders, including multiple sclerosis and age-related cognitive decline.
Diabetes doesn’t just attack the nerves and the heart—its effects are felt throughout the body. That’s why scientists are examining whether ALA can tackle other diabetic complications: in lab studies it has forestalled diabetes-related kidney and eye damage. (Check blood-sugar levels regularly when using ALA, especially if you’re taking other glucose regulators.)
While diabetes is one of the most common causes of nervous system damage, it isn’t the only one. In test tube studies ALA has promoted chemical reactions that encourage neurons (nerve cells) to survive and grow; as a result some scientists believe this natural antioxidant may eventually play a role in treating degenerative nerve disorders. Such research is in its beginning stages, but the results are still intriguing. For example, in mice ALA has slowed progression of a disorder that mimics multiple sclerosis in human beings (Journal of Neuroimmunology 3/04) and improved age-related memory loss when used with N-acetyl-cysteine (NAC), another antioxidant supplement (Journal of Neurochemistry 3/03). A number of other conditions that become more common with age may also benefit from ALA, including arthritis and thinning skin.
If you suffer from both diabetes and the nerve damage it causes, ask your practitioner about ALA. It just may help your feet and the rest of you feel happy. –Lisa James
Lower Cholesterol Naturally!
October 06, 2006 09:41 AM
Because of organizations like the American Heart Association (AHA), we’ve learned a lot about cholesterol and how it affects our health. Thanks to these educational organizations, we know that high cholesterol levels can increase our risk for heart attacks and strokes and, by lowering these levels, we reduce these risks as well as keep our hearts and blood vessels healthy. We also know that our cholesterol levels can be improved through exercise, diet, and weight loss.
Although we’ve learned a lot through these educational organizations, there are still a few misconceptions about cholesterol. One of these being that not all cholesterol is harmful. There are both “good” and “bad” forms of cholesterol and a good balance between the two is what is needed for a healthy heart. Because so much emphasis is placed on lowering “bad” cholesterol levels, not enough attention is paid to the benefit of raising “good” cholesterol levels (HDL). Research states that raising HDL levels can provide even greater protection against cardiovascular disease than just simply lowering “bad” cholesterol levels. By raising HDL levels by simply 1%, the risk of heart disease can be lowered by 2% in men and 3% in women. Many studies have shown that low HDL cholesterol levels are an independent risk factor in heart disease. This is extremely important because we’ve learned that despite efforts to change a person’s diet and exercise habits, some people’s cholesterol levels are still unhealthy.
Prescription drugs to lower cholesterol are now available and have been proven by multiple studies to be very successful. The statins’ effectiveness in reducing LDL (“bad”) cholesterol has produced highly significant reductions in heart attacks and strokes. Although these medications do lower cholesterol levels, their side effects must be considered. Statin drugs can cause liver irritation, reduce CoQ10 levels in the body, are associated with myopathy, and are even linked to a rare and sometimes fatal condition called rhabdomyolysis. These drugs also have a relatively small effect on good (HDL) cholesterol levels. Thankfully, there are safe and effective solutions available that can help you manage your cholesterol levels naturally. However, first we must review what we know about cholesterol and heart disease.
Cholesterol is a fat-like substance needed to help digest fats, strengthen cell membranes, make hormones and insulate nerves. Although it is found in every cell of the body, cholesterol is mainly made in the liver, as well as cells lining the small intestine. Even though our bodies make all the cholesterol we need, we also get cholesterol from the foods we eat, such as egg yolks and organ meats. All foods from animal sources contain cholesterol, while plant derived food, including peanut butter and avocado, contains no cholesterol at all.
Cholesterol is important to many functions of the body. However, too much cholesterol in the bloodstream is extremely dangerous. After blood cholesterol reaches high levels, it builds up on the artery walls, and thus increasing the risk for blood clots, heart attack, and stroke. If the cholesterol clogs any of the coronary arteries, the heart’s supply of oxygen and nutrients will diminish, resulting in coronary heart disease, angina, or even heart attack.
Because cholesterol and other fats can’t dissolve in the blood and thereby can’t travel on their own, they have to be transported to and from the cells by lipoproteins. The two major lipoproteins are low density lipoproteins (LDL or “bad cholesterol) and high density lipoproteins (HDL or “good cholesterol”) LDLs carry cholesterol throughout the body to the cells and cause artherosclerosis by clogging up our arteries with fat. On the other hand, HDL prevents the fat buildup by carrying it away from the arteries and to the liver where it can be eliminated. Although high levels of LDL are associated with cardiovascular disease, high HDL can drastically reduce your risk of heart disease. As a result, the AHA has established three guidelines to keep your heart healthy: HDL levels about 40 for men and above 50 for women, LDL levels between 100 and 159, and a total cholesterol (HDL and LDL) of under 200.
Triglycerides are fats used as fuel by the body and a source for metabolism. These levels can fluctuate easily but increased levels are almost always a sign of too much carbohydrate and sugar intake. High amounts of triglycerides make the blood less capable of transporting oxygen and are another factor for cardiovascular disease. Thankfully, the HDL and LDL blend mentioned earlier can safely and effectively lower triglyceride levels.
It has been shown that high levels of HDL cholesterol are inversely related to coronary artery disease risk. However, what people do not know is that there are different subtypes of HDl, including HDL-2 and HDL-3. HDL-3 is produced by the liver and intestines and is responsible for scooping up free cholesterol from the blood vessel walls. The cholesterol carried by HDL-3 is chemically modified, forming a larger-sized subtype, known as HDL-2, or “mature HDL.” HDL-2 transports cholesterol to the liver for processing and elimination, and its molecules are then recirculated in the blood stream. Research has shown that HDL-2 provides more heart-protection because it moves the cholesterol away from arterial walls, and holds a greater number of receptor sites which allows it to carry a larger amount of cholesterol to the liver.
Although many prescription medications have been developed to lower bad cholesterol, there are very few medications that target good cholesterol. Therefore, patients with naturally low HDL cholesterol, who can not alter these levels through diet and exercise, have limited medical options to reduce their risk of heart disease. Multiple nutrients have been clinically shown to favorably alter good cholesterol levels including: vitamins C, E, B6, B12, niacin, folic acid, magnesium and selenium, with protein-building amino acids, powerful antioxidants such as coenzyme Q10, alpha Lipoic acid, N-acetyle cysteine, and policosanol, and extracts of hawthorn, garlic, grape seed, and soy isoflavones. Although this HDL-boosting combination does not result in a significant reduction in LDL, antioxidants found in this formulation can help stabilize LDL and prevent build up in the arterial wall.
This formula combines essential vitamins and minerals, at levels recommended by the American Heart Association. It contains amino acids, antioxidants, and botanicals that have all been used safely for years. No serious adverse effects have been found following supplementation and the combination is safe to use with statin drugs.
Plant sterols, found in nuts, vegetable oils, corn, and rice are structurally similar to cholesterol and are able to block its absorption. Each day the liver receives about 800 mg of cholesterol from intestinal absorption through receptor sites. After entering these channels, the cholesterol is absorbed into the bloodstream. Since plant sterols look similar to cholesterol, they fit perfectly into these receptor sites and block the absorption, which allows the cholesterol to remain in our intestines where it can eventually be excreted. A large amount of plant sterols reduces the amount of cholesterol transported from the intestinal tract to the liver. This cholesterol reduction causes a decrease in LDL levels.
Even if a person does not have high cholesterol levels, reducing bad and raising good cholesterol greatly reduces their risk for ever developing chronic heart disease. Due to side effects, physicians do not normally prescribe statin drugs to people without actual heart disease of high LDL cholesterol levels. Instead, they recommend dietary changes. The HDL-boosting combination and LDL-lowering pantethine and plant sterols blend can effectively help people with heart disease, uncontrolled cholesterol levels, high triglyceride levels, or people who just want to improve their heart health.
Sytrinol 150mg - Now Vitamins
August 29, 2006 03:14 PM
Sytrinol 150mg – Cholesterol Formula
Now Vitamins Sytrinol is a revolutionary new dietary supplement that was carefully developed to help support healthy cholesterol and triglyceride levels. This is made possible based on Sytrinol’s high concentration of polymethoxylated flavones (PMF’s) from citrus, palm tocotrienols and other proprietary constituents. Studies have shown that this novel blend of cardiovascular supporting compounds can help maintain cholesterol and triglyceride levels that are already within a healthy range.*
Polymethoxylated flavones, or simply PMF’s are a type of potent, highly active bioflavonoid commonly found in citrus fruits. Tangeretin and nobiletin are two of the most potent, and their ability to support healthy cardiovascular function is backed by over 25 years of well-documented research. In addition to the role they play in preserving the integrity of healthy cells, it has been theorized that Polymethoxylated flavones posses the ability to maintain healthy cholesterol levels. They do this by inhibiting the formation of two key cholesterol building blocks – apolipoprotein-B and triglycerides. Without these, the body loses its ability to construct LDL cholesterol, thus resulting in a more healthy total cholesterol pool.
Palm tocotrienols, an equally beneficial component of Sytrinol, have also been shown to affect toe production of cholesterol. Tocotrienols, like vitamin E, has strong antioxidant properties that allow it to protect cell membranes. Additionally, they have been shown in studies to reduce blood platelet aggregation, inhibit the formation of arterial plaque and decrease the oxidation of LDL cholesterol.*
This potent combination is what ultimately allows Now Vitamins Sytrinol to provide exceptional lipid profile protection. For added support, we’ve included 50mg of Milk Thistle, 50mg of Alpha Lipoic Acid and 10mg of Policosanol, per serving.
Sytrinol is a proprietary and registered trademark product of Source One Global Partners.
Buy Sytrinol at Vitanet ®
HDL Booster - Boost your good cholesterol
March 16, 2006 12:51 PM
(Product No. 02922)
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
<![if !supportLists]>· <![endif]>Formulated by Dr. Dennis Goodman, Chief of Cardiology at
<![if !supportLists]>· <![endif]>Clinically studied to increase good cholesterol levels up to 23%*1
<![if !supportLists]>· <![endif]>All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
<![if !supportLists]>· <![endif]>Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-Lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-Carnitine (as L-carnitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
Benefits of Best Alpha Lipoic 35!
February 12, 2006 03:11 PM
Effer-C NUTRITION YOU CAN DRINK
December 27, 2005 09:49 AM
Your Cells Supercharge Your Cells
December 20, 2005 11:30 AM
Your Cells Supercharge Your Cells
The differences between aging and growing old are poles apart. Sure, they may sound similar in nature. But when you think about it, the two are as different as night and day. Growing old is about retirement and travel and enjoying what you’ve worked an entire life for. Aging, on the other hand, summons images of wrinkled skin, brittle joints, cloudy minds and medicine cabinets full of prescriptions. It’s safe to assume that the majority of us want to look, live, and feel better as we grow old. Not the opposite. Many of us are on the right track - committed to a healthy lifestyle that includes regular exercise and a well-balanced diet. And yes, these do serve as a solid foundation for good health during our golden years. It is our cells, however, that ultimately determine who grows old, and who just ages.
Still, slowing the proverbial hands of time is not all about health clubs and organic produce. If you want to grow old gracefully, you must nurture the ten trillion cells that defi ne you physically. Why? Because these cells are constantly under attack by free radicals - unstable molecules that either lack, or have an unpaired number of electrons. They scour the body in search of stable cells, and do whatever they can to rob them of their electrons, a process more formally known as oxidation. Considering that it’s environmentally impossible to completely avoid contact with the billions of airborne toxins that cause free radicals, the only other option is to safeguard your healthy cells. Making the commitment to a healthy lifestyle is the fi rst step in the process, and can be accomplished by eating healthier foods, exercising on a regular basis, and paying close attention to what you are exposed to environmentally.
The next step is to nourish and protect your cells. The best way to do this is to consume foods that are rich in antioxidants and other cell-friendly nutrients. Unfortunately, this task is often much easier said than done. Today’s average adult is busier than ever, making it far more diffi cult to consume fresh, unprocessed meals 100% of the time. This does not, however, imply that all hope is lost. Over the years, the nutritional sciences have made stunning advances that afford you the opportunity to live your life while still safeguarding the integrity of your most basic building blocks. Here are a few of the best.
Antioxidants work at the cellular level to paralyze the free radicals that cause oxidation throughout the body. Some of today’s most popular nutrients and dietary supplements fall into this category. They include vitamins A, E, and C, Selenium, Zinc, Alpha Lipoic Acid, Lycopene, Lutein, CoQ10, in addition to a host of others. And though similar in function, each of these free radical fi ghters has a unique role within the body.
Take CoQ10 for example. It’s present in every cell of the body, and is especially important for cardiovascular support. Lutein has been used extensively to prevent oxidation in the macular regions of the eyes. Zinc is a powerful immune system booster that has become extremely popular during cold and fl u season. Alpha Lipoic Acid is both fat and water soluble, and is commonly referred to as the “universal” antioxidant based on its ability to quench free radicals anywhere in the body.
Immune Boosting Herbs
Herbs such as Astragalus, Olive Leaf, Rhodiola, Echinacea, Panax Ginseng and Ashwaganda have been used for centuries to help support healthy cells and strong, responsive immune systems. They’ve also been shown to exhibit natural synergistic effects when used together. Today, they remain one of the most popular ways to naturally promote all-around wellbeing. When it comes to supporting healthy cells, NOW is pleased to offer one of the best selections of antioxidants, herbs and immune support formulas. Be sure to look for these and other great products at fi ne health food retailers, nationwide.*
OPCs (proanthocyanidins) are high-powered polyphenol antioxidants that belong to the fl avonoid family. Grape seed extract, pine bark extracts such as pycnogenol and enzogenol, bilberry, gingko biloba, resveratrol and others all fall into this category. Research continues to suggest that OPCs work in the same manner that traditional antioxidants do, however their ability to eradicate free radicals is much greater and more versatile. Equally appealing, OPCs can easily cross the blood barrier of the brain to help protect brain and neural tissues from the damage caused by oxidative stress.
Throughout history, many civilizations have relied on organic mushroom extracts to encourage wellness. What we know now is that mushrooms such as Shiitake, Maitake, Reishi and others are rich in 1,3 Beta-glucans - soluble fi ber compounds that help support both innate and adaptive immunity. In addition, the active compounds in some mushrooms have been shown to stimulate the production of microphages, T cells, and other natural killer cells. These biological warriors serve at the front line when it comes to responding to bacterial attacks. They are of immeasurable value to the immune system, though drastically lacking in today’s average diet. In just the past few years, more and more healthconscious individuals have learned fi rst-hand how benefi cial they can be in the preservation of healthy cells.
Pomeratrol™ Fact Sheet
December 19, 2005 09:09 AM
Pomeratrol™ Fact SheetNeil E. Levin, CCN, DANLA 9/28/04
USER: Those needing antioxidant protection; People with a family history of cell growth abnormalities; Anyone concerned with aging
KEY INGREDIENT(S): Pomegranate fruit standardized extract 200 mg. (Punica granatum) containing 80% total polyphenols, including 40% Ellagic acid, Resveratrol (100% trans-resveratrol) 20 mg. from a blend of Japanese knotweed root extract (Polygonum cuspidatum) and grape skin extract (Vitis vinifera)
POTENTIAL BENEFITS: Ellagic acid is a polyphenol compound found in raspberries, strawberries, pomegranates, and other fruit. It has been shown to normalize cell death of abnormal cells, a process called apoptosis. This enhances the body’s cell growth control system by providing an important plant substance. It may bind to DNA to prevent damage to this all-important genetic material. This is a key step in preventing cell damage that leads to signs of aging.
The American Cancer Society says that research in animal and laboratory models has found that ellagic acid inhibits the abnormal growth of certain cells. Research at Ohio State University indicates that berries typically contain a few milligrams per ounce of ellagic acid, the actual level varying quite a bit from variables such as species, variety and growing conditions.
Resveratrol is an antioxidant compound that is a phytoestrogen, or plant estrogen, which is protective of hormone-mediated cells in the body. Resveratrol is a potent antioxidant if stabilized. If not stable, it may quickly metabolize out of the body. This compound is believed responsible for some of the beneficial effects of moderate red wine drinking on the cardiovascular system. Resveratrol is also considered to be beneficial to smokers’ lung tissue if it is stabilized to last long enough in the system to be transported there. Resveratrol is also an inhibitor of the COX-2 inflammatory enzyme and encourages cell death (apoptosis) of abnormally growing cells. In insect experiments resveratrol even repaired DNA, leading to a longer life for healthy cells even as it helped get rid of unhealthy cells. Again, this ability to protect cells and help the body rid itself of abnormal cells is a key factor in preventing signs of aging. One liter of red wine contains between 1.5 and 3 mg. of resveratrol.
OTHER IMPORTANT ISSUES: Resveratrol is a difficult substance to stabilize. Because of the difference between resveratrol produced in the oxygen-poor environment in red wine and the form of resveratrol in unstabilized supplements, it has long been thought that resveratrol supplements were not very effective in comparison with wine. Knowing the importance of how a resveratrol supplement is metabolized, Now’s scientific staff has recently developed a special technique of stabilizing this compound in order to have an antioxidant effect closer to drinking a good glass of wine. While both trans and cis forms of resveratrol are naturally occurring, most of the recorded health benefits are attributed to the trans form. Now’s Pomeratrol provides trans-resveratrol.
DOSE: One capsule per day. Resveratrol has been used safely in studies at doses equivalent to 500 mg./day.
COMPLEMENTARY PRODUCTS: Other antioxidants and plant compounds: Vitamin C, pycnogenol, grape seed extract, and alpha Lipoic acid.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. There are some indications that resveratrol is a mild anticoagulant ("blood thinner"), and it also may help keep blood vessels to remain open and flexible. Caution should be used by those on blood-thinning drugs. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
GliSODin Anti-Aging and Antioxidant Protection
December 19, 2005 08:47 AM
GliSODin Anti-Aging and Antioxidant Protection
In the time it takes you to finish reading this article, you, your body and your cells will have aged. Some, more than others. Nevertheless, every second that ticks away should serve as a reminder that our time here is temporary. How much time we actually end up with depends on many things. Diet. Lifestyle. Environment. Superoxide Dismutase? I’ll explain. What some of the healthiest individuals fail to realize is that our bodies age from the inside out. Aging is not the result of passing time, but rather the result of what we’re exposed to environmentally, physically and chemically. It is the integrity of our cells, not our clocks, that determine how smooth the aging process fares.
Each day, we’re subjected to millions of elements that affect us in ways seldom seen, felt or noticed. From the moment we’re born, we rely on our cells to work around the clock - producing energy, fighting infections and sustaining life. These same cells eventually determine the rate at which we show (or hide) our age.
Taking into consideration that our planet has no shortage of toxins & germs, the need to safeguard our cells becomes very real. Constant exposure to exhaust, secondhand smoke, heavy metals, lead, fluoride and uncountable other noxious compounds should ideally provide us with nothing more than a routine immune system workout. Unfortunately, over long periods they hinder our “resistance” abilities and become stepping stones to accelerated aging.
Antioxidants. We’ve all heard the term before, and may even have a general understanding of their role. But to better grasp just how vital they are, it helps to know what’s happening at the cellular level. Free radicals are unstable molecular thieves that often lack electrons. To compensate, they rob healthy cells - a process better known as oxidation. Antioxidants work with the immune system to prevent oxidation, and clean up the mess it leaves behind. Hence, the name.
There are two types. Exogenous antioxidants are derived from our diet and include vitamins A, E, and C along with others such as alpha Lipoic acid, selenium, CoQ10, grape seed, pycnogenol and zinc. To date, we’ve been limited to exogenous antioxidants as a way to increase the rate at which our body wards off oxidation. They are not, however, our first line of defense. At birth, each and every one of us is equipped with three primary endogenous enzymatic antioxidants; SOD (Superoxide Dismutase), Glutathione Peroxidase (GPx) and Catalase.
While both types of antioxidants are beneficial, we’ve become reliant on those from the diet to compensate for our inability to boost the effectiveness of our 3 primary antioxidants. For years, researchers have been examining ways to enhance the activity of our built-in bodyguards. One in particular, Superoxide Dismutase (SOD) has been of foremost interest. SOD targets what many researchers regard as one of our greatest health threats and aging accelerators - Superoxide radicals. These highly reactive, merciless molecules incite enormous amounts of oxidative stress and are capable of wreaking havoc on healthy cells. When cells are left unprotected by SOD, the results can be disastrous - respiratory problems, premature aging, memory loss, cardiovascular challenges, vision failure and joint structure damage, among others.
Until now, we’ve been at the mercy of our natural SOD reserves to fight superoxides. Researchers have been working feverishly to produce an effective oral SOD supplement, but have continually encountered a frustrating hurdle - exposure to gastric acid denatures SOD, rendering it useless. As a result, the only effective way to supplement SOD was through injections. These, however, only yielded short-term spikes. And then something remarkable happened that changed everything. Nutrition scientists in France determined that by combining Cucumus melo (a melon high in SOD) with a wheat gliadin stabilizer, it would be possible to prevent SOD from deteriorating in the digestive tract, while preserving it in the blood for extended periods. Not only is this the answer to a puzzle that has plagued researchers, it’s a breakthrough that will impact the life of anyone seeking longevity and vitality.
As the first proven oral SOD supplement ever introduced to the public, GliSODin® has taken antioxidant protection, immune support and antiaging science to an entirely new level. The primary function of GliSODin® is to scour the body for superoxide radicals and reduce them to less reactive ions that can be swept away; a process known as dismutation. In addition, GliSODin® reduces the oxidation vulnerability of healthy cells, protects mitochondrial activity and safeguards DNA structure.
What’s most remarkable is that GliSODin® has actually been shown to stimulate the body’s own natural production of all three enzymatic antioxidants, including SOD. For the first time in history, we will have the ability to enhance the effectiveness of our body’s primary defense mechanism.
New GliSODin® from NOW® represents the ultimate in antioxidant protection. By increasing one’s level of SOD while stimulating the natural production of Glutathione Peroxidase and Catalase, GliSODin® delivers antioxidant protection unlike any previously released dietary supplement. Remember, the aging process begins at a level that we simply can not see, the cellular level. Shielding your cells from superoxide damage is one of the smartest steps you can take against aging before your due time. GliSODin® has made this a reality.
The Free Radical Theory
December 14, 2005 12:11 PM
The popular theory has been the subject of a great deal of research. Developed by Denham Harman, M.D., Ph.D., at the University of Nebraska in 1956, the free radical theory proposes that unstable molecules known as free radicals are responsible for inflicting extensive cellular damage, which causes cell death and dysfunction and eventually, disease. The most common type of free radicals are oxygen derived, and free radical damage is often referred to as oxidation.
Environmental sources of free radicals include radiation (I.E., sun exposure, X-rays), ozone and nitrous oxide, heavy metals (i.e., mercury, cadmium, lead), smoke, alcohol, saturated fat, and other chemicals and pollutants. The body itself generates free radicals in performing essential bodily functions including energy production and immune activities. Fortunately, the body also has the ability to create antioxidants to neutralize the free radicals and prevent extensive cellular damage. When free radicals are not neutralized by antioxidants, they inflict large-scale cellular damage which can cascade and lead to age-related degenerative diseases such as osteoarthritis, osteoporosis and age –relaged macular degeneration. For example, free radical damage to joint cells may cause the cartilage to become rough or break down, and can lead to the development of osteoarthritis. Antioxidants are needed to comb at free radicals and prevent this cellular damage. “Oxidative stress can lead to DNA mutations, cell death, and disease, all of which contribute to aging,” said Gerald R. Cysewski, president and chief executive officer (CEO) at Cyanotech corp. “Antioxidants are produced naturally by the body to combat oxidative stress by neutralizing free radicals. Increasing the amount of antioxidants in one’s system by consumption of supplements can provide further protection from the damaging effects of free radicals.”
Because the body is continually assaulted by free radicals, antioxidant supplementation is often necessary. “by taking certain nutrients that our bodies stop producing over time, supplements help us to maintain a youthful look and health, which in turn enhances the quality of life,” Alkayali said. “Furthermore, supplements can help decrease oxidative stress that may otherwise accompany age-related illness and disease.”
Many Substances are known antioxidants including certain enzymes, vitamins, phytochemicals and minerals, and include Vitamin C, Vitamin E, alpha-Lipoic acid, coenzyme Q10 (CoQ10), Carotenoids, Selenium, superoxide dismutase, melatonin, quercetin, catechins, and zinc.
Consuming a diet high in plant sources of powerful antioxidants is an important step to deter ageing, because nutrients from foods are often highly bioavailable and can act synergistically to increase their health benefits. Garlic contains several antioxidant phytochemicals and minerals including allicin, beta-carotene, quercetin, selenium and zinc, and may have a protective effect against stomach and colorectal cancers.
Catechins are potent antioxidants flavonoids, with the best known source being green tea; they include gallocatechin (GC), epigallocatechin (EGC), epicatechin (EC) and epigallocatechin gallate (EGCG). These antioxidants are being studied for their powerful abilities to combat free radical damage. In particular, EGCG has been researched for its reported protection against certain cancers and Alzheimer’s disease.
Green Foods such as seaweed, sea vegetables, young grain grasses and shoots, broccoli, cabbage and other green leafy vegetables pack a nutritional punch due to their concentratged amounts of antioxidant carotenoids, vitamins and the enzyme superoxide dismutase (SOD). SOD is produced by the body and neutralizes free radicals known as superoxide radicals, which cause damaging fat oxidation. GliSODin is a patented form of SOD derived from cantaloupe and bound to a wheat protein for superior bioavailability. “GliSODin promotes the body’s production of its own endogenous antioxidants, including SOD, catalase and glutathione peroxidase, in virtually every cell,” said Eric Anderson, brand manager at P.L. Thomas. “This activation of the cellular antioxidant defenses across the whole body creates a state of alertness against any shock of oxidative stress, including sun rays, to which our body may be exposed.”
Pomegranates contain two powerful antioxidants—ellagic acid, derived from fruit’s seeds, and punicaligans, found in the juice. “Research has shown that the juice from the pomegranate, rich in polyphenols, reduces oxidative stress by helping to produce enzymes to fight free radicals,” Alkayali said. NeoCell Corp. manufactures of ellagic-acid based Pomegranate Power, while P.L. Thomas supplies POM40p, a kosher-free pomegranate juice extract standardized to 40-precent punicocides, polyphenols belong to the punicalagin family.
Consumer demand is on the rise for products that address degenerative health conditions, including supplements that support function of the bones, joints, eyes. According to a June 2005 report by the freedonia group, “Bone and joint care products will continue to dominate the health maintenance segment, spurred by a growing customer base and a plethora of new and improved products expected to soon enter the marketplace.” The report also projected rapid gains for vision care. “Demand for vision care products will be propelled by aging baby boomers who are becoming aware of debilitating eye conditions and seeking both preventive measures and ameliorative treatments.” Dietary Supplements can help prevent and ease symptoms of age-related diseases affecting the joints, bones and eyes, including osteoarthritis, osteoporosis and age-related macular degeneration (AMD).
Tru-E Bio Complex
December 08, 2005 04:58 PM
Tru-E Bio Complex TMNeil E. Levin, CCN, DANLA 7/27/05
LIKELY USERS: Most Americans are deficient in Vitamin E 8,9,10; People needing superior antioxidant protection3,5,6; People needing cardiovascular or cholesterol support27,30,31; People needing nervous system support7; Those wanting healthier skin6; Diabetics may need additional Vitamin E24 KEY INGREDIENTS: Tocopherols from IP-Preserved, non-GMO Soy; Tocotrienols and tocopherols from non-GMO virgin palm; Tocotrienols from non-GMO annatto seed
MAIN PRODUCT FEATURES: NOW Tru-E Bio ComplexTM is a unique biologically balanced, patent-pending formula designed to provide optimal Vitamin E activity. This product features 100% natural, Non-Genetically Modified sources of all 8 isomers (forms) of the Vitamin E “family” in ratios similar to what is found in a healthy diet. It provides the superior benefits of foodsource Vitamin E versus those obtained from traditional E supplements.
NOW® Tru-E Bio ComplexTM has been carefully blended to supply high levels of the natural gamma and delta “desmethyl” forms of both tocopherols and tocotrienols. This is important because recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues. This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants. This science-based natural Vitamin E supplement is unlike any other and the first to combine all of these benefits in one convenient non-GMO formula! 25-32
Recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues.1-4, 25-32
This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants.1,4-7
Levels of Vitamin E above 100 IU daily are associated with decreased risk of coronary heart disease and certain types of cellular disorders, as well as enhancement of immune function. These vitamin E intakes are considerably above levels obtainable from diet alone. 11,12,13
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:
This is a product that is Patent Pending, based on months of research into optimal forms, potencies and ratios of the 8 isomers of natural Vitamin E. All of the Vitamin E formulas currently on the market use potencies of tocopherols that are very dissimilar to what is found in a healthy diet, with either too low or too high amounts of gamma and alpha tocopherols for a good balance. Some do not even include tocotrienols.
All of the Vitamin E formulas on the market that do contain a mixture of tocopherols and tocotrienols tend to use either 400 IU or 100 IU of alpha tocopherol, some as little as 50-60 IU, combined with varying doses of gamma tocopherol. We have reduced the alpha tocopherol from the standard 400 IU per capsule to 200 IU, allowing more gamma tocopherol in the capsule to follow the typical ratio in a healthy diet. Other brands either cut the alpha tocopherol too low (to keep the gamma tocopherol at a good level) or else cut the gamma and other tocopherols too low (to keep the alpha tocopherol at 400 IU).
Special care was used to maintain a certain ratio of tocopherols and of tocotrienols that is unique and from natural sources. Our formula is also unique in mixing sources of tocotrienols to achieve our desired balance, whereas other formulas include only one source, despite the dissimilarity of the mixture to what is found in a healthy, varied diet.
Other formulas use either Vitamin E derived from genetically engineered soybeans and/or add soybean oil from similar sources as a base. NOW uses expensive non-GMO sources, the first formula to do so, with no soybean oil added. This enhances the quality of our product compared to every other formula on the market.
We use the expensive virgin palm oil rather than the cheap palm distillates because it is un-denatured and contributes additional, valuable oil nutrients such as CoQ10, Squalene and Sterols. Also, much of the clinical research done on tocotrienols was done using virgin palm oil sources 32
Natural Vitamin E is more effective than synthetic Vitamin E.14 - 23
SERVING SIZE & HOW TO TAKE IT: One or two capsules per day, preferably with meal(s). Oils enhance the absorption of Vitamin E. Concentrated fiber supplements may decrease the absorption of Vitamin E, so it is best not to take both at the same meal.
SYNERGISTS: Antioxidants (Alpha Lipoic Acid, Vitamin C Complex, Pine or Grapeseed Extracts, VitaBerry Plus+, CoQ10, etc.), Plant Sterols, Fish Oil, Flaxseed Oil, GliSODin, EGCg Green Tea Extract, Lecithin, Nuts and Seeds
SPECIFIC: Aspirin and blood thinners should not be taken with Vitamin E without physician’s approval. Many other pharmaceutical drugs deplete Vitamin E, adding to the likelihood that a person will be deficient.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
1. Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) g-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714-722.
Co-Enzyme B-Complex Fact Sheet
December 08, 2005 04:40 PM
Co-Enzyme B-Complex Fact SheetNeil E. Levin, CCN, DANLA 8/1/05
LIKELY USERS: People with poor digestion or low stomach acid, People needing ENERGY, People desiring metabolism support.
KEY INGREDIENTS: CoEnzyme B-Vitamins plus synergists
MAIN PRODUCT FEATURES: B Complex Vitamins are needed by the body for energy production, synthesis of hormones and blood cells, healthy nervous system function, and numerous other metabolic processes. The forms of the B Vitamins found in foods and most supplements, however, are not readily utilized by the body. They require conversion into their active forms before they can perform their functions as cofactors in biochemical reactions. NOWR Co-Enzyme B-Complex contains B Vitamins already in their active or "Coenzyme" forms. This enables the body to use them more quickly and efficiently because, once absorbed, they are transported directly to their site of action, requiring no conversion. 1
B Complex Vitamins are needed by the body for energy production, synthesis of hormones and blood cells, healthy nervous system function, and numerous other metabolic processes 1, 2. The forms of the B Vitamins found in foods and most supplements, however, are not readily utilized by the body. They require conversion into their active forms before they can perform their functions as coenzymes in biochemical reactions 1, 2.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOWR Co-Enzyme B-Complex tablets are enteric coated to enhance bioavailability by allowing delivery to intestinal absorption sites intact, unharmed by stomach acids.2 Our Quality department had to qualify several new ingredients for this formula.
This formula is enhanced with added Coenzyme C10 (CoQ10), Alpha Lipoic Acid, Betaine (TMG), Vitamin C, and both coenzyme forms of B-12 (Methylcobalamin and Dibencoside) and is suitable for vegetarians and vegans.
SERVING SIZE & HOW TO TAKE IT: Two tablets daily, preferably in divided doses. This enteric-coated tablet is best to take between meals (one or more hours before a meal or hours after a meal), as it has an acid-resistant coating that dissolves beyond the stomach and needs to transit quickly past the stomach.
COMPLEMENTARY PRODUCTS: Vitamin C, TMG (Betaine), Lecithin (Choline, Inositol)
SPECIFIC: Please discuss your use of B-Vitamins with your physician, especially if you are using any medications.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Shils ME, Olson JA, Shike M (eds.) (1994) Modern Nutrition in Health and Disease, Eighth Edition. Chapters 20-26, 28, 30. Lea & Febiger Philadelphia.
Enzogenol® Pine Bark Extract Fact Sheet
December 07, 2005 05:30 PM
Enzogenol® Pine Bark Extract Fact SheetNeil E. Levin, CCN, DANLA 4/14/05
LIKELY USERS: Those seeking antioxidant protection; People trying to defeat the effects of aging KEY INGREDIENTS: Enzogenol® from New Zealand Pine Tree bark (Pinus radiata) Rutin (200 mg) and Grape Seed Extract (50 mg)
MAIN PRODUCT FEATURES: Enzogenol® is a powerful formulation of antioxidant bioflavonoids extracted from the bark of the New Zealand Pine (Pinus radiata) that is comparable to flavonoid formulations of other pine bark products. The flavonoids found in Enzogenol have been shown in clinical and non-clinical studies to support cardiovascular health and to protect cells and tissues from the damaging effects of oxidative stress. NOW® Enzogenol® also contains Rutin and Grape Seed Extract for their synergistic antioxidant benefits.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: Enzogenol® is a powerful and highly effective formulation of antioxidants extracted from fresh New Zealand pine bark – one of the most comprehensive complexes of natural antioxidants. A breakthrough in processing technology combines all of these antioxidants in an Enzogenol® capsule in exactly the same ratios as are present in the tree's bark. What's more, the revolutionary pure-water extraction process doesn't use toxic solvents like traditional extraction processes do.
SERVING SIZE & HOW TO TAKE IT: One to four capsules a day as an antioxidant dietary supplement.
COMPLEMENTARY PRODUCTS: Other antioxidants including Vitamin C, VitaBerry Plus+TM, Alpha Lipoic Acid, NAC, etc.
CAUTIONS: There are no specific cautions with this product.
GENERAL CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is given on the product label because it represents my own understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993 Oct 23;342(8878):1007-11. PMID: 8105262 Keli SO, Hertog MG, Feskens EJ, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med. 1996 Mar 25;156(6):637-42. PMID: 8629875
Ames, BN, Shigenaga, MK, Hagen, TM (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922
CLA Extreme Fact Sheet
December 07, 2005 12:59 PM
CLA Extreme Fact Sheet Neil E. Levin, CCN, DANLA 01/31/05
LIKELY USERS: People wanting to control body fat; People wanting to increase their body’s lean mass (muscle tissue); People wanting an oil that helps to reduce pro-inflammatory body chemicals; Those wanting to prevent undesirable cellular changes through diet KEY INGREDIENT (S): CLA from safflower oil, L-Carnitine amino acid, Guarana Seed extract (20% naturally occurring caffeine), Green Tea extract (40% polyphenols), Chromium Picolinate
MAIN PRODUCT FEATURES: Conjugated Linoleic Acid (CLA) is a derivative of linoleic acid, an essential fatty acid. The softgel is formulated with CLA (derived from safflower oil), Green Tea extract (polyphenols), Guarana extract (caffeine), L-Carnitine, and Chromium (III) Picolinate for synergistic effects of reducing body fat and increasing lean muscle mass.
OTHER IMPORTANT ISSUES: One study, titled "Efficacy and Safety of One-Year Supplementation with Conjugated linoleic Acid in Moderate Overweight," found that compared to placebo, CLA-supplemented subjects had Body Fat Mass index scores averaging 9% lower than the placebo group and had Lean Body Mass results showing lean muscle mass averaging 2% more than the placebo group. Analyses of blood tests showed no side effects over this one-year period. CLA plus Guarana reportedly reduces the size and number of fat cells in another report. CLA may also reduce insulin resistance and prevent undesirable cellular changes.
AMOUNT and HOW TO USE: One to five capsules a day, preferably with meals.
COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, Vitamin E, other Antioxidants
CAUTIONS: CLA may reduce insulin resistance, so people on blood sugar medications may not need as much of their drugs. Use with caution to avoid an overdose of your blood sugar medication when using this oil. Please notify your physician about your supplement use if you are using any drugs!
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 79(6):1118–1125 (2004).
Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-1 0,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 80(6):1626–1633 (2004).
Aminot-Gilchrist DV, Anderson HDI. Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1159S–1163S Suppl. S (2004).
Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui YZ, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127(3):777–791 (2004).
Bergamo P, Luongo D, Rossi M. Conjugated linoleic acid - Mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. Cell Physiol. Biochem. 14(1–2):57–64 (2004).
Bouthegourd JC, Martin JC, Gripois D, Roseau S, Tome D, Even PC. Fat-depleted CLA-treated mice enter torpor after a short period of fasting. Appetite 42(1):91–98 (2004).
Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK. Conjugated linoleic acid induces human adipocyte delipidation - Autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279(25):26735–26747 (2004).
Cheng WL, Lii CK, Chen HW, Lin TH, Liu KL. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappa B pathway. J. Agric. Food Chem. 52(1):71–78 (2004).
Choi JS, Jung MH, Park HS, Song JY. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20(11–12):1008–1017 (2004).
Cortes HN. CLA and body composition: Research shows conjugated linoleic acid can help maintain a healthy balance between lean muscle and body fat. Agro Food Industry Hi Tech 15(2):49–51 (2004).
Dauchy RT, Dauchy EM, Sauer LA, Blask DE, Davidson LK, Krause JA, Lynch DT. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. Cancer Lett. 209(1):7–15 (2004).
Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med. Sci. Sport Exercise 36(5):814–820 (2004).
Field CJ, Schley PD. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Am. J. Clin. Nutr. 79(6):1190S-1198S Suppl. S (2004).
Hirao A, Yamasaki M, Chujo H, Koyanagi N, Kanouchi H, Yasuda S, Matsuo A, Nishida E, Rikimaru T, Tsujita E, Shimada M, Maehara Y, Tachibana H, Yamada K. Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats. J. Nutr. Sci. Vitaminol. 50(1):9–12 (2004).
Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 323(2):679–684 (2004).
Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions. Lipids 39(7):611–616 (2004).
Lamarche B, Desroches S. Metabolic syndrome and effects of conjugated linoleic acid in obesity and lipoprotein disorders: the Quebec experience. Am. J. Clin. Nutr. 79(6):1149S–1152S Suppl. S (2004).
Malpuech-Brugere C, Verboeket-van de Venne WPHG, Mensink RP, Arnal MA, Morio B, Brandolini M, Saebo A, Lassel TS, Chardigny JM, Sebedio JL, Beaufrere B. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Res. 12(4):591–598 (2004).
McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SB, Trevisan M, Freudenheim JL. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB study). Cancer Epidemiol. Biomarkers Prevent. 13(9):1480–1484 (2004).
Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 80(4):887–895 (2004).
Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KWJ. Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis 25(7):1185–1191 (2004).
O'Shea M. Clarinol(TM) CLA (Conjugated Linoleic Acid): the weight of evidence supports a safe and efficacious product for weight management. Agro Food Industry Hi-Tech 15(4):24–26 (2004).
O'Shea M, Bassaganya-Riera J, Mohede ICM, Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1199S–1206S Suppl. S (2004).
Rainer L, Heiss CJ. Conjugated linoleic acid: Health implications and effects on body composition. J. Am. Dietetic Assoc. 104(6):963–968 (2004).
GliSODin® (The Antioxidant Catalyst) 100 mg Fact Sheet
December 07, 2005 12:47 PM
GliSODin® (The Antioxidant Catalyst) 100 mg Fact Sheet Neil E. Levin, CCN, DANLA 01/31/05
LIKELY USERS: People with exposure oxidizing chemicals; People wanting to increase their body’s production of antioxidants.
KEY INGREDIENT (S): SOD (Superoxide Dismutase antioxidant enzyme) from melons Organic Wheat Grass leaf
MAIN PRODUCT FEATURES: Patented, clinically tested form of SOD to ensure absorbability; Protects cell mitochondria from oxidative stress that leads to genetic damage the cells; Reduces markers of cellular oxidative damage in the blood; May increase the body’s production of important antioxidants including SOD, Glutathione and Catalase.
OTHER IMPORTANT ISSUES: This product contains wheat protein as an aid to protecting the SOD and increasing its absorption. The base of organic wheat grass synergistically provides additional, naturally occurring levels of SOD and other nutrients, though this additional SOD is not well absorbed.
AMOUNT and HOW TO USE: One to three capsules a day, preferably between meals. If taken at mealtime avoid taking non-chelated (alkaline) forms of minerals at the same meal and take this capsule at the beginning of the meal to speed its transit time through the stomach and minimize exposure to alkaline foods and supplements that may cause the capsule to break down prematurely. That could potentially reduce the effectiveness of this form of SOD. The coating is designed to survive stomach acid and dissolve in the more alkaline conditions of the small intestine.
COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, EGCg Green Tea Extract, Whey Protein Isolate, Selenium, NAC, Vitamin C, other Antioxidants.
CAUTIONS: Contains wheat and wheat proteins, should not be used by people who are gluten-intolerant. Gluten intolerance may manifest with neurological, not abdominal symptoms, so please consider having a gluten intolerance test if you do have any neurological problems. Please notify your physician about your supplement use if you are using any drugs!
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Free Radic Res. 2004 Sep;38(9):927-32. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum Ulm, D-89073 Ulm, Germany. PMID: 15621710 [PubMed - in process]
Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet
December 07, 2005 12:16 PM
Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: People with exposure to toxins that stimulate liver activity; People with exposure to infections that may have damaged liver tissue
KEY INGREDIENT (S): Milk Thistle extract (Silymarin), Glutathione, NAC, Bupleurum extract, Grape Seed Extract, Dandelion Root extract, Artichoke Leaf, Schisandra and about a dozen additional herbs, along with synergistic ingredients
MAIN PRODUCT FEATURES: This formula was developed by a physician based on his clinical experience.
Artichoke leaf has antioxidant properties and restores healthy growth to liver cells.
Bupleurum may promote normal cell growth, immune function and is a staple of Chinese liver formulas. Dandelion Root may serve as a natural down-regulator of inflammatory chemicals in the body. NAC supports liver Glutathionestores (antioxidant, detoxifier, heavy metal chelator). Schisandra protects liver cells from toxins and may help to regenerate damaged cells. Milk thistle’s antioxidant Silymarin improves liver function tests and protects liver cells against oxidative damage. It also protects liver cells by blocking and removing toxins from the liver. Silymarin aids in regenerating injured liver cells and blocks fibrosis.
OTHER IMPORTANT ISSUES: Samuel Verghese, M.D. (AM), Ph.D., BCIA-EEG, DAAPM, holds a degree in Alternative Medicine and specializes in Nutritional, Ayurvedic and other Alternative Health Solutions. He is certified as a BCIA-EEG Associate Fellow.
AMOUNT TO USE: Three or more capsules a day, preferably with meals.
COMPLEMENTARY PRODUCTS: Antioxidants (supports liver detoxification), Alpha Lipoic Acid, EGCg Green Tea Extract, Astragalus, medicinal mushrooms (shiitake, reishi), SAM-e (may improve bile flow and promotes methylation to detoxify chemicals), TMG, lecithin, thymus glandular extract, Cordyceps.
AVOID: acetaminophen, alcohol, iron supplements (also red meat, fortified flour)
CAUTIONS: This formula should not be used by pregnant women, nursing mothers children or those with liver problems unless recommended under the supervision of a healthcare professional. Please notify your physician about your supplement use if you are using any drugs! Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Salmi HA, Sarna S. Effect of silymarin on chemical, functional and morphological alterations of the liver. A double-blind controlled study. Scand J Gastroenterol 1982;17:517–21.
Green Tea Extract Fact Sheet
December 07, 2005 10:23 AM
LIKELY USERS: People wanting antioxidant protection; Those trying to control cholesterol; People with high levels of inflammatory iron, including eaters of red meat; Those seeking to avoid caffeine, but wanting the benefits of green tea.
KEY INGREDIENT(S): Green tea extract (Camellia sinensis) 400 mg
MAIN PRODUCT FEATURES:
Total EGCg content: 50% (200 mg.) (Epigallocatechin gallate, a Catechin) Total Catechins content: 80% (by HPLC method) (Catechins are a form of Polyphenol) Total Polyphenols content: 98% (by UV method) Polyphenols, especially catechins (including EGCg), are the main active ingredients in green tea, which act as antioxidants and bind iron, which may prevent some iron-dependent inflammation.
Less than 1% caffeine content, naturally occurring (versus one cup of green tea’s roughly 40 mg. of caffeine). There should be only around 3 mg. of caffeine, per capsule.
OTHER IMPORTANT ISSUES: