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Date: June 25, 2005 10:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HISTORY

HISTORY

Ginkgo has achieved unprecedented popularity within the last decade and has become a familiar household term. Because interest in treating diseases like Alzheimer’s has escalated over the last decade, the biochemical capabilities of ginkgo in regard to brain function have been investigated and are still being researched. Ginkgo is one of those herbs that has become intrinsically connected with notions of herbal elixirs capable of pre s e rving youth and promoting longevity.

Ginkgo comes from the oldest species of tree in the world dating back some 200 million years. Some ginkgo trees have been known to live well over an average of 1000 or more years. The ginkgo tree is also known as the “maidenhair tree” and would have probably become extinct if the trees had not been cultivated in Far Eastern temple gardens and nurtured by Oriental monks.

Ginkgo is a deciduous conifer with separate male and female types. It resembles the pau d’arco tree and like pau d’arco, possesses an unusual immunity to insects and diseases. Ginkgo’s remarkable hardiness enabled it to survive the atomic blast at Hiroshima. Because of its unprecedented longevity, ginkgo biloba has sometimes been referred to as a living fossil.

Ginkgo has been used in China for over 5000 years. The Chinese refer to the fruit of the ginkgo tree as pa-kwo. This fruit is sold in markets throughout China and resembles dried almonds. Ginkgo fruit is pleasant tasting when fresh, but can become quite disagreeable if allowed to get overly ripe. Asians have relied on extracts of the fan-shaped ginkgo leaf since 3,000 B.C. to heal a wide variety of ailments.

The Chinese have been acquainted with the curative powers of ginkgo for centuries and have typically used the herb for ailments related to aging, such as circulatory disorders, mental confusion and memory loss. In China, ginkgo seeds, called baigou, are considered lung and kidney tonics and are used in conjunction with acupuncture. Ginkgo seeds also help to tonify the urinary system, so they are used in cases of incontinence and excessive urination.1

Practitioners of Chinese medicine routinely use ginkgo leaves. Ginkgo was introduced into Eu rope in 1730 and was we l l received, not for its medicinal value, but for its ornamental appeal. It is used extensively in landscaping because of its lovely fern-like leaf. It was brought to America in 1784 to the garden of William Hamilton who lived in Pennsylvania.

Decades passed before the healing properties of ginkgo we re investigated. Consequently, it has been part of the herbal repertoire only since the 1980s. During this time, it became technically feasible to isolate the essential components of ginkgo. Pharmacologically, there are two groups of substances which are significant compounds found in ginkgo: the flavonoids, which give ginkgo its antioxidant action, and the terpenes, which help to inhibit the formation of blood clots. The majority of scientific interest has Focused on Ginkgo’s ability to improve the circulation of blood. O ver the past twenty years, scientific testing on the plant has dramatically escalated. Ha rva rd professor Elias J. Core y, Ph . D , synthesized ginkgo’s active ingredient, ginkgolide B, for the first time in the laboratory. Consequently, stepped-up research in this country and in Eu rope resulted. Ginkgo has been the subject of over 300 scientific studies and continues to intrigue scientists. Much modern research has confirmed ancient applications of ginkgo as well as discovered new ones.

Ginkgolide, the active component of the herb, is what creates most of ginkgo’s biochemical attributes. Exactly how ginkgolide B functions is not yet known. One theory is that the compound somehow interferes with a chemical found in the body called PAF (platelet activating factor). PAF has been implicated in cases of graft rejection, asthma and other immune disorders. PAF antagonists have been identified from a variety of medicinal plants. These compounds help to explain the pharmacological basis of several traditional medicines and provide a valuable new class of therapeutic agents.

Particular attention has been paid to ginkgo’s powerful actions on the cardiovascular system. Thousands of Europeans use this herb for peripheral circulatory disorders. As a circulation booster, ginkgo has accumulated some impressive credentials. Because proper circulation is vital to each and every body function, virtually all body systems can benefit from ginkgo therapy.

Ginkgo’s relationship to brain function has also spawned considerable interest. In 1985, Rudolf Weiss said of ginkgo,

“ Significant improvement in mental states, emotional lability, memory, and the tendency to tire easily, have been reported.”

Ginkgo is currently planted in groves and used for a number of medicinal purposes. It is harvested in the summer and can be used in extract, tincture or infusion forms. The therapeutic properties of ginkgo seem endless. Continuing re s e a rch promises to further uncover additional health benefits of this remarkable botanical. Ginkgo extracts are among the leading prescription medications in France and Germany. Currently, millions of prescriptions for ginkgo are written by physicians worldwide.

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Date: June 25, 2005 09:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HISTORY

HISTORY

For thousands of years amazing magical and medicinal powers have been attributed to garlic. Prized as a legendary protectant against vampires in Transylvania, it has also been used to enhance sexual prowess and fight off infections. Referred to as “the stinking rose,” it is mentioned in Bible, the Talmud, and in the Odyssey by Homer as well. The Egyptians looked to garlic as a tonic which boosted physical strength and consumed it while building the pyramids. The Greeks utilized its laxative properties, and the Chinese prescribed it for high blood pressure. Vikings and Phoenicians alike extolled the virtues of garlic and used it both for flavoring foods and treating disease.

Garlic is a hardy, perennial bulb which is native to the Mediterranean regions of Africa and Europe. Along with onions, leeks, chives and shallots, garlic is a member of the lily family. The botanical name for garlic, allium sativum may have been derived from the celtic word all which refers to “pungent.” The edible portion of the garlic plant grows underground and consists of a cloved bulb.

Hippocrates believed that garlic could treat uterine cancer and Native Americans used it for stomach cancer. During the Bubonic Plague years in Europe, garlic was used to boost immunity against the infectious organism responsible for so many deaths. Several accounts relate that survivors of the plague were frequently those who had routinely ingested large amounts of garlic. A sixteenth- century herbalist writes, referring to garlic, “The virtue of this herb is thus. It will unbind all wicked winds within a man’s body.”1

During the eighteenth century, Russians utilized garlic to treat influenza. Eventually, garlic would become known as “Russian penicillin.” American colonists regarded garlic for its ability to kill parasites.

In the nineteenth century, Louis Pasteur finally proved scientifically that garlic contains antibiotic properties. His discovery led to the initiation of hundreds of studies which have substantiated his findings. What was thought to be nothing more than a culinary ingredient has medicinal value. Garlic can effectively kill bacteria, fungi, viruses and parasites. In the late nineteenth century, garlic was routinely used by physicians as an effective treatment for typhus, cholera and whooping cough. It was highly recommended by medical practitioners and considered as staple treatment for infection. Albert Schweitzer used garlic for treating amebic dysentery in Africa. Early in this century, tuberculosis was treated with garlic and it was also used as an antibiotic/antiseptic for wounds during World War II. American and European doctors alike noted a remarkable high cure rate in tuberculosis patients treated with garlic.

2 Septic poisoning and gangrene, which can so quickly develop in battlefield wounds were prevented to a significant degree by using garlic. During the 1950’s Chinese scientists used garlic to successfully treat influenza. Subsequently, western studies found that garlic was an effective treatment for the common cold. Today the widespread use of antibiotics have relegated garlic to the back burner of medicinal therapies for infection. The discovery of penicillin resulted in classifying garlic as nothing more than a folk remedy. Unfortunately, for several decades its medicinal potential was no longer taken seriously by scientists. Over the last decade, scientific interest in garlic has dramatically escalated. In 1990, the First World Congress on the Health Significance of garlic and Garlic Constituents was held in Washington D.C. Herbalists have always considered garlic as an effective treatment and preventative agent against colds, flu and other infectious diseases. The present focus on garlic as a medicinal agent promises to support the notion that garlic should be utilized by medical practitioners much more than it currently is.

Recently, medical research has Focused on garlic’s potential value in treating cardiovascular disorders and as an anti-cancer agent. This renewed interest in garlic has contributed to the development of the “Designer Foods Program” which is sponsored by the National Cancer Institute.3 This agency investigates foods that may be effective cancer preventatives. Garlic is one of those foods which may have profound cancer prevention potential.

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Date: June 24, 2005 05:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available

The average American’s life expectancy has risen dramatically over the last 100 years. Ideally those extra years will be quality ones. High levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Free radicals cause oxidative stress, which is a major cause of accelerated aging. Source Naturals presents the science of RENEWAL ANTIOXIDANTS. This Bio-Aligned Formula™ is a significant advancement over other products currently available. No other formula provides the broad range of high potency, established and newly discovered water and fat-soluble antioxidants that RENEWAL ANTIOXIDANTS delivers.

Bio-Aligned Antioxidant Support

RENEWAL ANTIOXIDANTS™ supports multiple body systems with a balanced spectrum of plantioxidants™ (botanical extracts with unparalleled ability to combat free radicals), vitamins and specialty nutrients that have powerful antioxidant properties. Research suggests dietary antioxidants help balance and modulate free radical activity and help maintain structure and function of important components of cells such as lipids, proteins, and DNA.

Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to cells and tissues. Free radicals are unpaired electrons that can damage cells and compromise the function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of lipid and water soluble antioxidants to minimize this negative effect. No other antioxidant formula follows the science better than RENEWAL ANTIOXIDANTS to defend against the widest spectrum of destructive free radicals, including peroxyl, hydroxyl, and superoxide radicals, and singlet oxygen.

Healthy Heart

Antioxidants neutralize destructive free radicals and support cardiovascular health by halting the oxidation of cholesterol. Cholesterol is only harmful to us if it becomes oxidized. Oxidized cholesterol is an unstable molecule that damages arteries. RENEWAL ANTIOXIDANTS contains hearthealthy antioxidants including gamma E and tocotrienols, which are major lipid-soluble antioxidants that help maintain the integrity of cell membranes by preventing lipid oxidation. The formula includes hawthorn berry and grape seed, CoQ10, lycopene and other powerful antioxidants for heart support.

Nourishing the Brain

Antioxidants are critical for brain and nerve tissue because the brain is mostly composed of fats, which are very sensitive to free radical damage. Research has shown that stress can directly set in motion mechanisms that promote aging, which affects brain and nerve tissue. Ginkgo has been shown to increase memory performance and learning capacity as well as improve blood flow. It is also a free radical scavenger. RENEWAL ANTIOXIDANTS also contains DMAE, bilberry, CoQ10, grape seed, lipoic acid, vitamin B-2 and lutein for broad spectrum support.

Liver Support

Powerful antioxidants help minimize stress damage to liver cells and tissues, thereby supporting detoxification. N-acetyl cysteine is a powerful antioxidant. It is also a precursor to glutathione, a critical antioxidant and detoxifying substance produced in the liver. Silymarin is known for supporting the regeneration of the liver. Since the liver is prone to fat incursion, which makes it vulnerable to oxidative damage, the following fat soluble antioxidants provide critical protection: CoQ10, lipoic acid, ascorbyl palmitate, and gamma E.

Immune Defense

The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex interactions involving many different organs. White blood cells generate enormous amounts of destructive free radicals in order to kill invading organisms. Vitamin C, a free radical scavenger, is concentrated in these white blood cells at a much higher level than in surrounding fluid. This extends their life and effectiveness by providing them with a built in defense mechanism against their own free radicals. RENEWAL ANTIOXIDANTS provides water and fat-soluble vitamin C (ascorbyl palmitate and ascorbic acid) along with vitamin A, beta carotene, CoQ10, lipoic acid, quercetin, selenium, gamma vitamin E, tocotrienols, zinc and turmeric, for added immune defense.

Skin & Connective Tissue

Skin is rich in lipids, proteins, and DNA, which are extremely sensitive to oxidation. Age-related changes due to oxidation, loss of elastic fibers and thickening of collagen fibers, cause skin to become fragile and less supple. A broad array of antioxidants protects skin and helps maintain its structure and tone. These include beta carotene, vitamin C, vitamin E, grape seed, zinc, amla (Phylanthus emblica), quercetin, DMAE, manganese and myricetin. Amla is a very effective herbal tonic. It is rich in polyphenols and vitamin C.

Clear Vision

Eye tissue is particularly prone to the effect of free radicals. Vision involves light being Focused through the lens onto the retina. The macula, or center of the retina, receives the most light. However, sunlight is a powerful free radical generator. Lutein, a potent, fatsoluble antioxidant concentrated in the macula, helps maintain the integrity of the macula and the blood vessels that supply the macular region. The eye also has aqueous tissue that is better protected by water-soluble antioxidants, such as bilberry and grape seed. RENEWAL ANTIOXIDANTS provides these ingredients, along with lycopene, zeaxanthin, lipoic acid, vitamin A, beta carotene and ascorbyl palmitate to support healthy eyes.

Energy Generation

Mitochondria, the tiny energy factories within the cells, are the major source of free radicals produced by our own bodies. These components of cells produce ATP (the energy molecule) and provide energy for all cellular activity; therefore, antioxidants are crucial to keep the levels of oxidants they produce in check. RENEWAL ANTIOXIDANTS provides the antioxidant power of green tea, lipoic acid, zinc, vitamin B-2, CoQ10 and Mega H-, a source of electron rich hydrogen ions. Coenzyme Q10 is fat-soluble and its primary functions include activity as an antioxidant and as a cofactor in many metabolic pathways, particularly in the production of ATP in oxidative respiration.

DNA Protection

DNA, the blueprint for all molecules in the body, can be altered or damaged by oxidation. Protecting DNA is important for optimal health of all cells and tissues. According to invitro research, certain compounds, such as curcumin (from turmeric) and quercetin, can directly protect against strand-breakage and base oxidation. RENEWAL ANTIOXIDANTS contains these ingredients along with rosemary, pomegranate, raspberry, blueberry leaf, and carnosine. In in-vitro studies, L-carnosine reduced glycation, a process in which DNA and protein are damaged by glucose.

Living Longer, Living Better Strategies for Wellness

Wellness Revolution

Taking personal responsibility for your health and exploring safe alternatives to support prevention is the basis for the wellness revolution. Your health food outlet is leading the way with education and quality products to help you take control of your well-being. Source Naturals is pleased to partner with these outlets to bring you the cutting edge nutritional science of RENEWAL ANTIOXIDANTS. Antioxidant protection is a fundamental part of the holistic healing system. Make this profound formula the cornerstone of your anti-aging program today.

References

Clement, M., Bourre, J. Graded dietary levels of RRR-y-tocopherol induce a marked increase in the concentrations of a- and y-tocopherol in nervous tissues, heart, liver, and muscle of vitamin E-deficient rats. Biochimica et Biophysica Acta 1334 (1991) 173-181. Borgstrom, L. Pharmacokinetics of N-acetylcysteine in Man. Eur J Clin Pharmacol (1986) 31:217-222. Hipkiss, A.R., et al. Carnosine, a protective, antiaging peptide? Int J Biochem & Cell Biol. 30, May 1998, 863-868.

Heart and Blood Vessels Resveratrol, Gamma E, Tocotrienols, Vit C, Hawthorn Berry, Grapeseed, Myricetin, CoQ10, Ginkgo, Beta & Alpha Carotene, Zeaxanthin, Lycopene, Lutein, Astazanthin, Lipoic acid, Green Tea, Bilberry, Ginger, Turmeric, Blueberry Leaf

Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein

Liver Lipoic Acid, N-Acetyl Cysteine, Vit A, B-2,and C, Beta Carotene, Silymarin, CoQ10, Selenium, Zinc, Gamma E, Tocotrienols, Turmeric, Ginger Glutathione, Wheat Sprouts

Immune System Vit A & C, Beta Carotene, CoQ10, Lipoic Acid, Quercetin, Selenium, Gamma E, Tocotrienols, Zinc, Turmeric

Skin & Connective Tissue Beta Carotene, Vit B-2, C & E, Grapeseed, Lutein, Lycopene, Zeaxanthin, Zinc, Amla, Quercetin, Manganese, DMAE

Eyes and Vision Lutein, Beta Carotene, Vit A & C, Bilberry, Lycopene, Zeaxanthin, Lipoic Acid, Quercetin, Gamma E, N-Acetyl Cysteine, Selenium, Zinc

Energy Production and Metabolism Green Tea, Ginger, Mega H-, Ginkgo, CoQ10, Lipoic Acid, Zinc, Vit B-2, Carnosine DNA Protection Turmeric, Quercetin, Rosemary, Grapeseed , Resveratrol, Lycopene, Lutein, Tocotrienols, GliSODin®, Carnosine, Zinc, Manganese, Amla, Pomegranate, Raspberry leaf, Blueberry leaf

--
Vitanet ®

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Date: June 22, 2005 09:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CLA and Cows

CLA and Cows

Nutritional developments like that of CLA couldn’t come at a better time. America is a nation obsessed with weight, but successes in battling weight seem harder and harder to come by. Is there a nutritional reason for this? Have we been barking up the wrong tree in recent years, starving ourselves for fear of gluttony rather than looking at broader nutritional reasons for fat accumulation? For example, Dr. Cook says that modern nutritional dogma is that fat is bad. “I’m not sure the dogma’s right. We need to get down to very specific fatty acids.”51 One of the most exciting developments coming from CLA research is that modern animal-raising techniques may be partially responsible for those of us who eat meat getting fat around the middle, even though our consumption of meat may have declined or, at least, stayed about the same in recent years.

CLA has been declining in our diet. This one nutrient’s lack may mean many of us are gaining fat, despite eating less overall fat.52

This desire to simply eliminate fats without looking at the broader nutritional picture has its roots deep in our culture. The desire to starve ourselves to lose weight goes back centuries. We have often thought weight gain came solely from lacking self-control when, often, nothing could be further from the truth.

Take for example the experiences of conscientious objectors during World War II. These men who chose, for religious reasons, not to fight in the war, contributed in other ways. One group at the University of Minnesota underwent forced starvation to help scientists learn ways to help concentration camp victims recover after liberation.

Science learned many useful things, but one thing stands out. The objectors grew more hungry as they recovered and ended up weighing five percent more after they recovered than before the experiment began. (The same can be said for refugees and concentration camp victims, who also weighed more, on average after their ordeals than before.)53 This idea of dieting being the full answer to weight loss still persists, often tragically. Many have died of anorexia, obsessed with self-image. Others have died directly from ill-conceived meal replacement programs.54 In the 1980s, Americans spent $15 billion on diet soft drinks alone,55 but consumers weighed more on average when the decade was over than when it began. You’d think all of this energy and dieting spent on the effort would have helped people lose weight. (Thankfully, many people have succeeded in losing weight and keeping it off. According to Dr. Pariza, this may well be the most significant part of CLA, not so much in losing the weight, but in helping people keep it off.56)

To drive the point home further, consider your parents. They ate a diet that was likely higher in fat than yours. They never saw “lite” versions of snacks in the store. Yet they, in general, weighed less than we do. Why? Surely exercise may have had something to do with it, but, no one has the complete answer. It seems likely that nutrition too played a role. CLA itself may hold part of the reason. As we have seen, CLA nutrition means less fat and more protein in our bodies. Recent research is showing that the amount of CLA in cows has dropped substantially since the times of our parents. In 1963, scientists found that CLA was as much as 2.81 percent of milkfat. The amount of CLA in the milk products varied with the seasons. At some times during the year, cows ate grass. At other times, they ate feed. However, in 1992, Pariza and his colleagues did a large food survey and found that this variation in CLA is no longer occurring. Furthermore, the amount of CLA in dairy products rarely gets above 1 percent of the milkfat. 57

In another research paper in 1994, scientists noticed that Australian cows have as much as three or four time the amount of CLA in the meat from similar American animals. Why? These differences probably “reflect different feeding conditions.” 58

Today, farmers use more efficient feeding methods that rely less heavily on natural grasses. This means less CLA in the meat we eat, and less CLA can mean a higher percentage of fat on our bodies. Consider too that skim milk contains virtually no CLA with its no fat content. This lack of CLA may actually hinder some people’s efforts to lose weight.

The lesson here seems to be that gluttony guilt would be better Focused on balanced living. Healthy lifestyles coupled with the right supplementation can make a difference. CLA, though no magic bullet, adds to this lifestyle and could be the key that finally opens many weight (and fat) management doors. It could help many people keep the weight off.

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Date: June 22, 2005 09:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CLA and Body Fat

CLA and Body Fat

Of all the health concerns facing Americans today, few are as important and daunting as weight loss and body fat. In the 1980s, Americans gained an average of eight pounds each. That’s on the order of 1 million tons of flab—2 billion total American pounds.45 So large is the current girth that as many as two in three Americans could be termed overweight.46 Being overweight and having excess fat increases the risk of heart disease, some forms of cancer and diabetes. That collection of health challenges would be difficult enough, but being overweight has many problems that accompany it, including battles with self-esteem.

Let’s give a historical example of this story. The emotional power of being perceived as too fat is caught with pathos in the life of former U.S. President William Howard Taft. Taft, who is the only man to serve as both president and as chief justice of the Supreme Court, was noted for his honesty and his integrity. The nation mourned his death, but much of his internal story Focused on his battle with weight. One editorial cartoonist showed the island of Cuba tipping under his girth. Once, when he visited Japan, an entire village worked together to pull his rickshaw up a hill. When he married, his personal esteem showed when he told his wife that “I shall worry you so much with my appetite that you must gain strength to meet the trial.”

Taft refused to be seen on a horse because of how awkward he looked. At one point, he lost 75 pounds, but, like so many others, ended up gaining that amount back , and more, during the next 10 years. He died of athero s c l e rosis, something associated with being ove rwe i g h t .4 7 The tragedy of Taft is that, like so many suffering with weight trouble, he seemed to let it damage his self w o rth, when he was a great asset to his nation and to others. History and culture put into us that being overweight means lacking in self-control and being a glutton, when in reality this isn’t true. So many more factors are involved. Each person has a different metabolism. Certain nutrients can meet different needs, and a lack of those nutrients can lead to fat retention. CLA may be one of those nutrients, one of those factors in our diets that can change our shapes and that have nothing to do with self-control, just nutritional luck and knowledge. In a study of rats, 28 days after beginning the study, body fat in those that ate CLA was 58 percent less than in those who didn’t consume any (10.13 percent body fat versus 4.34 percent body fat, a highly significant difference). Also, the percent of muscle was about one percent more in animals that ate CLA. The weights of both sets of animals were about the same.48 (Muscle weighs more than fat. This can mean that you won’t necessarily lose weight with CLA, but would gain muscle mass, which is tighter and more shapely.) The research in this area is slightly newer, but it has been reproduced in studies on other animals.49 That more than one kind of animal has shown that body fat is lower with supplements of CLA indicates that it will likely benefit humans as well.

In July 1997, preliminary results of one of the first human studies involving CLA showed promising, preliminary results. For three months in 1997, 20 volunteers participated in a study, daily consuming an amount of slightly more than one gram of CLA at breakfast lunch and dinner. Three months later, their weights and body-fat percents were measured. Half of the group took a placebo. The average weight of the 10 who took CLA dropped by about five pounds (not enough to be statistically significant), but the body fat percentage dropped by about 15 to 20 percent, or from 21.3 percent of average body fat to 17 percent of body fat. Meanwhile, the group taking a placebo had little or no effect on either. Half of the people in the study were men and half were women. Two people in the study decided to drop out because they received unpleasant gastrointestinal upsets. One of those who dropped out was in the placebo group, the other in the group taking CLA.63

Nobody would suggest that CLA supplementation would be a pill freeing you to sit slug-like on the couch to watch M*A*S*H* re runs. A healthy, weight-conscious lifestyle requires many factors including exercise. As far as science can tell, CLA may not be essential the way certain vitamins are. If you consume no vitamin C, you can expect to get scurvy and die. There are no known deficiency diseases associated with an absence of CLA.

Japanese consumers, for example, get very little CLA in their diets, but they also eat food very low in fat, and their lives are among the longest in the world.50 So, the role of CLA supplementation in regulating weight is most useful for those with a typically high-fat Western diet. As the science grows, it seems clear that CLA will lead to better health and more hope for people struggling with body fat.

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Date: June 21, 2005 04:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The important role the liver plays in maintaining health

Most practitioners who practice various forms of natural medicine know the important role the liver plays in maintaining health in general. The liver is involved in thousands of biochemical mechanisms making it second only to the brain in importance and complexity. Natural health practitioners are also acutely aware of the detrimental effects on the liver of modern living, with its chemicals, excessive fat intake, pesticides, hormones, and stress. This suggests that we as a culture are in need of liver support. History suggests, and modern research is supporting, that botanicals have an important role to play in supporting a healthy liver.

Mechanistic Overview

The liver has an almost miraculous ability to biochemically transform, break down, store, eliminate, and build up the plethora of chemicals to which it is exposed. Many botanicals have a very specific effect of modifying these biochemical processes. Some botanicals can enhance the liver?s phase I (cytochrome P450) and phase II (glutathione conjugation) detoxification processes, promote the flow and production of bile (one means of eliminating toxins), inhibit the attachment of viruses or chemical antagonists to hepatocytes, strongly enhance the liver?s powerful antioxidant systems, or promote the regeneration of liver tissue-the liver being the only organ in the body except the skin able to regenerate itself. Many botanicals have been used historically for promoting liver health. Today, modern research is confirming these benefits while shedding light on their mechanisms of action. Following is an overview of a number of these botanicals.

Milk Thistle Silybum marianum

The extract of the seeds of milk thistle is perhaps the most well researched of all the liver supportive botanicals. Part of its benefit has been in its ability to scavenge free radicals and to stimulate the regeneration of hepatocytes. In Germany, it is the botanical extract of choice for use in supporting a healthy liver. Typically, an extract yielding a minimum of 70% silymarin (a specific class of flavonoids) is used clinically at a dose of approximately 420 mg of the extract daily (Morazzoni and Bombardelli 1995).

Schizandra Schisandra chinensis

Schizandra, known as bei wu wei zi in China, is one of the most widely used tonics of Chinese herbalism. Its original use was to support the health of the heart, kidneys and lungs and as a longevity tonic. Modern research has Focused attention on its role as an adaptogen and for supporting a healthy liver. Adaptogens are substances that positively affect overall health by reducing stress mechanisms which can contribute to a number of biochemical reactions that can be detrimental to health. While the mechanism of action of adaptogens has not been definitively determined, the existing literature suggests they work endocrinologically through the pituitary and adrenals and substantially reduce the negative effects that stress has on the system (Wagner et al. 1994). In China and Japan, the modern use of schizandra has Focused on its benefit in those in need of liver support. In one review of its pharmacological activity, stabilization of liver enzymes was reported in more than 5,000 people. The benefits were experienced within 20 days of administration of schizandra with 75% of patients returning to normal values (Chang and But 1986). A limited number of controlled studies similarly reported on the beneficial effects of the equivalent of 1.5 grams of schizandra for reducing elevated liver enzymes (Liu 1991). There are three primary mechanisms of action of schizandra reported with regards to its ability to support a healthy liver: 1) its ability to reduce lipid peroxidation induced by a number of different antagonists (antioxidant activity); 2) induction of hepatomicrosomal cytochrome P-450; 3) stimulation of protein biosynthesis and liver glycogen (Liu 1991). Such mechanisms make schizandra ideal as a liver-supportive botanical that is underutilized in the West.

Bupleurum Bupleurum chinense, B. falcatum

Bupleurum, also known as chai hu in China, is perhaps the most important of liver-supportive botanicals in China and Japan, and, like schizandra, is far underutilized in the United States, except by traditional Chinese herbalists. Traditionally, it has been regarded as an herb that helps to normalize the function of the liver from a traditional Chinese perspective. Modern research has identified a group of compounds known as saikosaponins that strongly support liver health (in humans and rats). Mechanisms of action specifically regarding liver health identified for bupleurum include anti-inflammatory activity, as well as its ability to stimulate the production and release of bile, thus facilitating the detoxification process (Wagner et al. 1996).

Sho-Saiko-To Minor Bupleurum

In Chinese herbalism, herbs are seldom prescribed singularly. Rather they are combined according to very sophisticated principles of formulation based on the differential diagnosis of the patient. One of the most widely used and researched botanical formulas for the health of the liver used in China and Japan is Sho-Saiko-To, known in China as Xiao Chai Hu Tang (Minor Bupleurum). This classic formula consists of the following botanicals: ginger, scutellaria, jujube, ginseng, licorice, pinellia and bupleurum. It is widely used throughout Asia for supporting liver health and currently is the subject of phase II clinical trials at Sloan Kettering. The formula with its main ingredient, bupleurum, was first introduced in Japan by Chinese Buddhist priests between the 6th and 8th centuries. Modern research suggests that Sho-Saiko-To modulates the immune response, specifically in addition to other mechanisms, by increasing levels of interleukin and interferon (Huang et al. 2001).

Holistic Context

To the same extent that herbs are seldom used singularly in Chinese herbalism, they are similarly used within a broader context that incorporates dietary and other lifestyle changes to support the botanicals. In my clinic, I routinely recommend that patients eliminate alcohol, coffee, sugar, and refined foods from their diet and eat whole grain foods, fish, and several servings of green vegetables daily along with their herbal program. For these individuals this is a simple program to follow, and many are able to live a normal productive life with a greater level of liver health. Such a liver-supportive program must be maintained as a way of life to lessen the burden that modern society and exogenous factors put on our livers.

Conclusion

The herbal world offers a potential natural health care approach that focuses on protecting and restoring the health and functioning of the liver. Both traditional experience and modern investigation suggest that botanicals can play a role in world health, specifically in promoting liver health.

Caution

The use of botanicals should be used under the guidance of a qualified health care professional. The combined use of conventional and natural therapies may not be appropriate. Before attempting to combine such therapies, discuss your therapeutic options with your primary health care provider.

References

Chang HM, But PH. 1986. Pharmacology and applications of Chinese materia medica. World Science. Singapore. Huang et al. Semi-quantitative analysis of cytokine mRNA expression induced by the herbal medicine sho-saiko-to (TJ-9) using a gel doc system. J Clin Lab Anal 15: 199-209. Liu GT. 1991. Pharmacological actions and clinical uses of Fructus schizandrae in recent advances in Chinese herbal drugs-actions and uses. Scientific Press Beijing. Morazzoni P, Bombardelli E. 1995. Silybum marianum (Carduus marianus). Fitoterapia LXVI (1):3-42. Wagner H, Noerr N. Winterhoff K. 1994. Plant adaptogens. Phytomedicine 1: 63-76. Wagner H, Bauer R, Peigen X, Jianming C, Offermann F. 1996. Chinese Drug monographs and analysis: Radix Bupleuri (chaihu). Verlag fuer Ganzheitliche Medizin Koetzting/Bayer. Wald, Germany.

Michael Tierra, L. Ac., O.M.D., is a clinician and world-renowned author of the best-selling Way of Herbs and Planetary Herbology. As product formulator for Planetary Formulas, he draws on 30 years of clinical experience to create formulas renowned for their dependability and effectiveness.

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Vitanet ®

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Date: June 14, 2005 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Truth in Labeling

Truth in Labeling by Diane Stanton Energy Times, June 14, 2004

Do you or don't you read food labels when you shop? If you don't, you're missing out on a prime source of information about your meals. If you want control of your health, focus on package labels and pick your foods carefully.

The large print on food labels focus on what are called macronutrients: carbohydrates, fat and protein. Some of the smaller categories convey information about vitamins, fiber, and minerals, as well as the totals of fat and saturated fat contained in food. So, you have no excuse for claiming ignorance about your diet: the truth is in the labels.

Food labels can be confusing to the uninitiated. Go into a big food store and you can be faced with what seems to be a forest of food information: more than 15,000 labels. Add to that fact that every year more than 30,000 new food products can be introduced to the marketplace, and what you're faced with is a jungle of food labels.

That overwhelming wealth of food label information doesn't mean you should throw up your hands in dismay and give up reading and deciphering labels. You should arm yourself against that sea of labels with knowledge and, by understanding them, end your confusion and build your health.

Label History

A hundred years or so ago, food labels were only required to list the name of the food contained inside the package. The contents, quality and processes used to make the food were often a mystery. Little or no disclosure to consumers was made about how their food was created.

By the early 1920s, the federal government, via the Food and Drug Administration (FDA), began requiring food companies to list the net weight of food on labels as well as the names and addresses of food processors and distributors. Finally, by the 1970s, listing basic nutritional information was mandated in a uniform way so that shoppers could have some basis for comparing foods. Then, in 1990, the Nutrition Labeling and Education Act made major alterations to the kinds of labels that had to be included on food packages.

The FDA and the US Department of Agriculture (USDA) required significant changes to food labels that were supposed to make it easier for consumers to eat healthier diets. The labels requirements of 1994 included five major changes:

Label Questions

Consumer questions regarding food labels have led researchers to look into ways to help shoppers comprehend what food labels tell them. These studies are designed to help consumers match up their nutrition requirements with the foods they buy.

For instance, at the University of Illinois at Urbana-Champaign, scientists have devised a label tool called See It, Do It, Teach It to help people improve their diets through comprehension of food label information. " One of the goals of the project was to help...teenaged girls and menopausal women understand how they can get the daily requirement for calcium into their diet in order to help prevent osteoporosis," says Karen Chapman-Novakofski, PhD, associate professor and nutritionist in the school's College of Agricultural, Consumer and Environmental Sciences.

According to the See It, Do It, Teach It program, you should think of food labels as consisting of two sections:

" Much more attention has been paid to what people should limit rather than the nutrients needed. The average consumer doesn't know, for instance, how much vitamin A 10% of the Daily Value is, or how much calcium 25% of the Daily Value is," Dr. Chapman-Novakofski says.

Upping Calcium Intake

In their eight-week study of people's calcium consumption (Journal of Nutrition Education and Behavior 4/04), the University of Illinois research team found that people didn't know how much calcium was in the food they ate.

After the initial part of the study, in which participants were shown how to look for calcium on labels, "the post-test revealed that the participants significantly increased their calcium intake to 821 mg per day, up from 372 mg per day," notes Dr. Chapman-Novakofski.

" That's a lot closer to the daily requirements of 1,200 mg per day for men and women over 50, 1,000 mg for men and women aged 19 through 50 and 1,300 mg per day for [youths aged] 9 to [18] years," she adds.

Parts of the Label

The first item at the top of a nutrition food label tells you the portion size that the label measures. An important point to remember: these sizes are determined individually by each manufacturer. Consequently, all of the other values on the label are measured per portion.

So, if you are comparing foods made by two different companies that employ very different portion sizes in their nutritional calculations, your label comparisons may be complicated.

Another fact to be aware of: the listed portion size may be an odd division of the food within the container and not reflect a common-sense division. For instance, some food packages are labeled as containing 2.5 portions.

And, to make things even more interesting, small boxes of candy that you might think contain barely enough for one helping may be labeled by the manufacturer as having two or more portions. As a result, if you eat the whole box, you often have to at least double the number of indicated calories, etc. to figure out the nutrients and calories you are consuming.

The section of the label that notes calories, calories from fat and percent daily values is listed under the portion size. Here you are told how many calories you consume when you devour one portion and how many of those calories are derived from fat.

This label focus on fat originated when consumers and dietitians were very concerned about Americans' fat consumption and hadn't yet switched their focus to carbohydrate consumption as a prevalent dietary health priority.

Also included on the label: the daily value percentages aimed at showing you how much out of a total day's intake of various nutrients a portion bestows upon you.

These percentage numbers are based on a theoretical analysis of a diet that contains 2,000 or 2,500 calories a day. (A notation at the bottom of the label tells you whether the calculation is based on 2,000 or 2,500.)

Carb Facts

If you've been eating a low-carb diet (or are planning this type of diet), the section of the label that lists carbohydrates may be especially useful. Under this heading, the label lists the totals for fiber and sugar.

No matter what diet you are on, dietary fiber is desirable, since it represents indigestible carbohydrates that both pass through you without conveying any calories and keep beneficial bacteria in your digestive tract healthy.

Most people want to limit their sugar totals, however, since this nutrient may raise your risk of being overweight and, when you eat a lot of it, may contribute to immune problems.

Interestingly enough, when food chemists compute what is in food, they perform lab tests known as assays to distinguish its ingredients. (The manner in which these tests are performed are very strictly regulated by the FDA.)

In fact, just about every nutrient listed on a food label is determined by laboratory test except for the carbohydrate content: the amount of water, fat, crude protein and ash are determined this way. But the total carbs are computed by simply subtracting the total of the other ingredients from the total amount of food, a kind of process of elimination.

So while fat and protein are measured with precise lab tests, carbohydrate totals are figured by the leftovers. (The water and ash, by the way, are not usually listed on food labels.)

Within the general carbohydrate group, are several categories of carbohydrates that produce very different effects in your body. These categories can be divided into sugar, sugar alcohols, dietary fiber and a collection of various chemicals that include organic acids, flavonoids, gums, lignans and others.

According to the FDA, the food label only has to list the total carbs, sugar and dietary fiber. But some food companies now list things like sugar alcohols.

Blood Sugar Effects

Not all of these types of carbohydrates behave the same way in your body. For example, when your body digests table sugar, it turns immediately into blood sugar. So sugar and most other carbohydrate is what we call "digestible carbohydrate." Other carbs, such as sugar alcohol or glycerine, can be digested but do not turn to blood sugar. Still others, such as dietary fiber, are indigestible and pass through your body without impacting your blood sugar level.

To date, the FDA has not Focused on these important biochemical differences and treats all carbohydrates alike. This means that when you look at a food label, you do not see a number for the carbs that impact your blood sugar level. To do so, simply subtract the number of grams of fiber from the total number of carbohydrate grams.

Net Carbs

Recently, the phrases "low carb," "net carb" and "impact carbs" have begun to appear on food labels. These are not defined by the FDA; they were put on labels by by companies to help consumers pick out foods that are acceptable on low-carb diets. To arrive at the total of net carbs, food companies subtract the total amount of fiber and sugar alcohol from the total carbohydrates.

Fiber Calculations

Since the body cannot digest fiber, this nutrient (which is still important for good health) is not calculated into the total amount of carbohydrates. As for sugar alcohols, while-technically speaking-these are carbs and they do have calories, they have little effect on blood sugar and usually are not counted in total carbohydrates.

According to the American Dietetic Association, people with diabetes who are managing their blood sugars using the carbohydrate counting method should "count half of the grams of sugar alcohol as carbohydrates since half of the sugar alcohol on average is digested.

" Fiber is not digested, however. If the serving of food has more then 5 grams of fiber one should subtract the grams of fiber from the total carbohydrate grams." As you can see, when it comes to food, as in most things, knowledge is power. If you want power over your health, you need power over the food you eat. The road to that power is by reading food labels. What's in the food you're eating every day may surprise you.

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Vitanet ®

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Date: June 13, 2005 07:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Celebrating Women: Age Is Just a Number

Celebrating Women: Age Is Just a Number by Carl Lowe Energy Times, March 10, 2004

As women age, their physical needs shift. The health challenges that face a woman in her thirties do not match those of a woman in her fifties.

At the same time, some basic health needs stay constant: At any age, every woman requires a wealth of vitamins, minerals and the other natural chemicals that fruits, vegetables and supplements supply. She also constantly needs families and friends to support her spiritual health.

As the internal workings of your body alter, your lifestyle must stay abreast of those adjustments. Peak health demands a finely tuned health program designed with your individual needs-and your stage of life-in mind.

Ages 30 to 45

When it comes to maintaining health, younger women might seem to have it easier than older women. If they exercise and stay in shape, they maintain more stamina than women 10 to 20 years their senior.

Unfortunately, many women in this age group mistakenly think they don't have to be as careful about their lifestyle habits and their eating habits as they will in later decades. But even if your health doesn't seem to suffer from poor eating choices or a sedentary lifestyle right away, your foundation for health in later life suffers if you don't care for yourself now.

By age 45 you should have established the good habits that will carry you successfully through the aging process. As an added bonus, good lifestyle habits pay immediate dividends. If you pay attention to your nutrients and get plenty of physical activity when younger, you'll feel more energetic and probably enjoy better emotional health.

Set Health Goals

According to Gayle Reichler, MS, RD, CDN, in her book Active Wellness (Avery/Penguin), good health at any age doesn't just come to you-you have to plan for it. In order to stick to good habits, she says, "living a healthy lifestyle needs to be satisfying." Reichler believes that you need to picture your health goals to achieve them: "Every successful endeavor first begins in the mind as an idea, a thought, a dream, a conviction." Good health at this age and in later years requires a concrete strategy and visualization of how your body can improve with a healthy lifestyle.

Your long-term health goals at this age should include an exercise program that will allow you to reach a physically fit old age with a lowered risk of disability. In addition, your short-term plans should encompass losing weight, staying optimistic, living life with more vim and vigor, increasing your capacity for exercise and lowering your stress.

As Reichler points out, "Your long-term goal and your ideal vision establish what you want to achieve....[You should do] something good...for yourself every day and every week that makes your life easier and more consistent with your goals."

Develop an Eating Plan

Today, the average American gains about two pounds annually. As a result, every year a greater portion of the US population is obese and overweight. By controlling your food intake earlier in life, you may be able to avoid this weight gain. In his book Prolonging Health (Hampton Roads), James Williams, OMD, recommends basic changes to your diet that can provide long-term support of your health:

Get Supplemental Help

If you're in your thirties or forties and you don't take at least a multivitamin, start taking one today! A large body of research shows that taking vitamin and mineral supplements over a long period of time significantly supports better health.

Calcium and vitamin D are two of the most important supplemental nutrients, helping to build stronger bones now that can withstand the bone-loss effects of aging.

Calcium can also help keep your weight down. One study of younger women found that for every extra 300 milligrams of calcium a day they consumed, they weighed about two pounds less (Experimental Biology 2003 meeting, San Diego).

In the same way, taking vitamin D supplements not only helps strengthen your bones, it can also lower your risk of multiple sclerosis (Neurology 1/13/04). In this study, which looked at the health records of more than 180,000 women for up to 20 years, taking D supplements dropped the chances of multiple sclerosis (although eating vitamin D-rich foods did not have the same benefit). And if you're thinking about having children at this age, a multivitamin is crucial for lowering your baby's risk of birth defects and other health problems. A study at the University of North Carolina at Chapel Hill found that women who take multivitamins during pregnancy lower their children's risk of nervous system cancer by up to 40% (Epidemiology 9/02).

" Our finding, combined with previous work on reducing several birth defects with vitamin supplementation and other childhood cancers, supports the recommendation that mothers' vitamin use before and during pregnancy may benefit their babies' health," says Andrew F. Olshan, MD, professor of epidemiology at the UNC School of Public Health. "We believe physicians and other health care providers should continue to educate women about these benefits and recommend appropriate dietary habits and daily dietary supplements."

In particular, Dr. Olshan feels that folic acid (one of the B vitamins), and vitamins C and A, are particularly important for lowering the risk of childhood cancers and birth defects.

Ages 45 to 55

When you reach this in-between age-the time when most women have moved past childbearing age but haven't usually fully moved into the post-menopausal stage-you enjoy a propitious opportunity to take stock of your health and plan for an even healthier future. One thing that may need adjustment is your sleep habits, as sleeplessness is a common problem for women in this age group. Even if you haven't been exercising or watching your diet until now, it's not too late to start. Making lifestyle changes at this age can still improve your chances for aging successfully.

For instance, it is at these ages that women should have their heart health checked. Research published in the journal Stroke (5/01) shows that having your cholesterol and blood pressure checked at this time more accurately shows your future chances of heart disease than having it checked at a later date after menopause, in your late fifties.

" The premenopausal risk factors may be a stronger predictor of carotid atherosclerosis [artery blockages] because they represent cumulative risk factor exposure during the premenopausal years, whereas the risk factors...during the early postmenopausal years have a shorter time for influence," says Karen A. Matthews, PhD, a professor at the University of Pittsburgh Medical Center. In other words, Dr. Matthews' research shows that if you have high blood pressure and high cholesterol before menopause, you are at serious risk for a stroke or heart attack soon after menopause: These are important reasons that you need to start improving your health habits immediately.

Increase in Heart Disease

Before menopause, a woman's hormones and other physiological characteristics usually hold down her chance of heart disease. After menopause, when hormones and other bodily changes occur, the risk of heart attacks and stroke in women rises significantly. (Heart disease is the leading killer of women.) At least part of this increased risk is linked to the postmenopausal decrease in estrogen production.

Dr. Matthews studied about 370 women in their late forties, measuring their weight, their BMI (body mass index, an indication of body fat compared to height), blood pressure, cholesterol and blood sugar. Ten years later, after the women had entered menopause, she and her fellow scientists used ultrasound to measure blockages in these women's neck arteries (a sign of heart disease).

The researchers found that indications of potential heart problems (such as high blood pressure, high cholesterol and being overweight) when women were in their forties did indeed forecast future difficulties.

" Women who had elevated cholesterol, higher blood pressures and increased body weight before menopause had increased blood vessel thickening and atherosclerotic plaque formation in the neck arteries after menopause. Such changes in the carotid arteries are associated with an increased heart attack and stroke risk," says Dr. Matthews.

Heart Health Factors

The four main lifestyle factors you should adjust at this age to support better heart function are diet, stress, exercise and weight. According to Dr. James Williams, "[M]ore than any other cause, dietary factors are the most critical factor in cardiovascular disease." He recommends eliminating "dietary saturated fatty acids as found in flame-broiled and fried meats." He also urges women to eat more fish and poultry, consume organic fruits and vegetables and cut back on refined sugar.

Stress becomes an ever more important heart disease factor at this age as estrogen begins to drop.

" Our study [in the lab] indicates that stress affects estrogen levels and can lead to the development of heart disease-even before menopause," says Jay Kaplan, PhD, of the Wake Forest University Baptist Medical Center (The Green Journal 3/02).

Dr. Kaplan's research shows that stress in women ages 45 to 55 may reduce estrogen earlier in life and make women more susceptible to the arterial blockages that lead to heart disease. "We know from [lab] studies that stress can lower estrogen levels to the point that health is affected," he says.

Stress can also hurt bone health: In a study of 66 women with normal-length menstrual periods, estrogen levels were low enough in half of the women to cause bone loss, making the women susceptible to osteoporosis.

Exercise and Weight

Although exercise used to be considered to be mainly a young woman's activity, the thrust of recent research suggests that physical activity actually becomes more important to health as you get older.

A 17-year study of about 10,000 Americans found that exercising and keeping your weight down is probably the most important thing you can do to lower your risk of heart disease as you enter your forties and fifties (Am J Prev Med 11/03).

Of the people who took part in this study, more than 1,500 people died of heart disease. Those who performed the most exercise were thinner and had a 50% chance less of dying of heart disease than overweight nonexercisers.

" The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, a researcher at the Albert Einstein College of Medicine in the Bronx, New York.

An added benefit of exercise: If you burn up calories exercising, you can eat more and not have to worry as much about being overweight.

Supplements and Diet

If you're a woman at midlife, a multivitamin and mineral is still good nutritional insurance. Eating plenty of fruits and vegetables are also important for getting enough phytochemicals, the health substances in plants that convey a wealth of health benefits.

As you enter this age group, your immune system gradually slows down. To help support immune function, eating produce rich in antioxidant nutrients, and supplementing with antioxidants like vitamins C and E as well as carotenoids, can be especially important. For example, a study of people with ulcers found that people with less vitamin C in their stomachs are more likely to be infected with Helicobacter pylori, the bacteria that can cause peptic ulcers and is linked to stomach cancer (J Amer Coll Nutr 8/1/03).

This research, which looked at the health of about 7,000 people, found that vitamin C probably helps the immune system fend off this bacterial infection.

" Current public health recommendations for Americans are to eat five or more servings of fresh fruits and vegetables a day to help prevent heart disease, cancer and other chronic diseases," says Joel A. Simon, MD, MPH, professor of medicine at the University of California at San Francisco.

Calcium and Bones

At midlife, calcium continues to be a vital mineral for supporting bone health.

According to Gameil T. Fouad, PhD, "It has been routinely shown that a woman's calcium status and level of physical activity (specifically, the degree to which she participates in weight-bearing exercise) are positively associated with bone mineral density. It is less well appreciated that this is a process which takes place over the course of a lifetime."

Dr. Fouad adds that calcium works in concert with other vitamins and minerals to keep bones healthy: "Research in the United Kingdom involving nearly 1,000 premenopausal women over age 40 illustrates those women with the highest bone density tended to have the highest intake of calcium. Surprisingly, this study also demonstrated that calcium does not act alone: those women with the best bone health also had the highest intakes of zinc, magnesium and potassium."

Dr. Fouad stresses that supplements should go together with a lifestyle that includes enough sleep and exercise to help the body stay in top shape.

" As a general guideline," he says, "a woman concerned with her mineral intake should take concrete steps to make sure she is getting adequate rest, is eating a well-balanced diet Focused on fresh fruits, vegetables and lean protein as well as getting adequate exercise....A multi-mineral containing bio-available forms of zinc, magnesium, copper and selenium is probably a safe addition to anyone's routine. Taking these proactive steps dramatically reduces the chances that deficiencies will arise."

Ages 55 and Beyond

Entering the post-menopausal phase of life can present challenging opportunities for a new perspective on life and health. While some signs of aging are inevitable, experts who have looked at how the human body changes with age are now convinced that healthy lifestyle habits can improve how well you can think, move and enjoy life well past age 55.

As Dr. Williams notes, "In your fifties, the force of aging is undeniably present: Your body shape changes and organ function declines, both men and women have a tendency to gain weight....Heart disease becomes more common, energy and endurance are considerably reduced and your memory begins to slip."

But Dr. Williams also points out that you don't have to age as rapidly as other people do. He believes you should employ a "natural longevity program...[that starts] to reverse the course of aging as early as possible."

One key to staying vital as you age is your outlook on life, an aspect of life that's greatly enhanced by strong social ties.

Avoiding the Aging Slowdown The latest research shows that one of the most crucial ways to slow the effects of aging is to exercise and keep your weight down. It won't necessarily be easy, though. The change in hormonal balance at this age makes the body more prone to extra pounds (Society for Neuroscience Meeting, 11/12/03).

" In women, it has been demonstrated that major weight increases often occur during menopause, the time in a woman's life in which cyclic ovarian function ends and the ovarian hormones estrogen and progesterone decline," says Judy Cameron, PhD, a scientist in the divisions of reproductive sciences and neuroscience at the Oregon Health & Science University.

In Dr. Cameron's lab trials, she has found that the decrease in estrogen after menopause "resulted in a 67% jump in food intake and a 5% jump in weight in a matter of weeks."

In other words, the hormonal changes you undergo as enter your late fifties causes your appetite to grow as well as your waistline: Developments that increase your chances of heart disease, cancer, diabetes, stroke and joint problems.

Vigilance against this weight gain is necessary to save your health: Start walking and exercising. Research on exercise in people aged 58 to 78 found that getting off the couch for a walk or other physical activity not only helps control weight but also helps sharpen your thinking and helps you become more decisive (Proceedings of the National Academy of Sciences, 2/16-20/04, online edition). This recent study, done at the University of Illinois at Urbana-Champaign, found that performing aerobic exercise improved mental functioning by 11% (on a computer test).

" We continue to find a number of cognitive benefits in the aerobic group," says Arthur F. Kramer, PhD, a professor of psychology at the Beckman Institute for Advanced Science and Technology at Illinois. "The brain circuits that underlie our ability to think-in this case to attend selectively to information in the environment-can change in a way that is conducive to better performance on tasks as a result of fitness." In simple terms, that means that walking at least 45 minutes a day boosts brain power as well as protecting your heart.

An Herb for Menopause

The physical changes that accompan> y menopause can be uncomfortable. But traditional herbal help is available: Black cohosh (Cimicifuga racemosa), an herb used for eons by aging women, has been shown in recent studies to be both safe and effective (Menopause 6/15/03).

" This [research] should reassure health professionals that they can safely recommend black cohosh to their menopausal patients who cannot or choose not to take HRT [hormone replacement therapy]," says researcher Tieraona Low Dog, MD, Clinical Assistant Professor at the University of New Mexico Department of Family and Community Medicine.

While HRT has been used to help women cope with menopause, a flurry of studies in the past few years have shown that HRT increases the risk of heart disease and cancer. Instead, black cohosh, which alleviates such menopausal discomforts as hot flashes, has been shown to be much safer.

Keeping Track of Crucial Vitamins

While continuing to take multivitamins and minerals at this age is important, some experts believe that as we grow older, vitamin D supplementation, as well as taking antioxidant nutrients, is particularly vital. Arthritis is a common affliction of aging, and rheumatoid arthritis (RA) is one particularly destructive form of this joint problem. But taking vitamin D can significantly lower your risk of this condition.

When scientists analyzed the diets of 30,000 middle-aged women in Iowa over 11 years, they found that women who consumed vitamin D supplements were 34% less likely to suffer RA (Arth Rheu 1/03).

Other vitamins are equally important to an older woman's well-being. For example, vitamins C and natural E have been found to lower the risk of stroke in those over the age of 55 (Neurology 11/11/03). In this study, smokers who consumed the most vitamin C and natural vitamin E were 70% were much less likely to suffer strokes than smokers whose diets were missing out on these vitamins.

Rich sources of vitamin C in food include oranges and other citrus fruits, strawberries, red and green peppers, broccoli and brussels sprouts. Sources of vitamin E include vegetable oils such as sunflower seed, cottonseed, safflower, palm and wheat germ oils, margarine and nuts.

Saving Your Sight

After age 55, your eyes are particularly vulnerable. Eight million Americans of this age are at risk for age-related macular degeneration (AMD), a condition that destroys structures in the back of the eye necessary for vision (Arch Ophthal 11/03). But you can drop your risk of AMD by taking supplements of antioxidant vitamins and zinc, according to researchers at Johns Hopkins' Wilmer Eye Institute.

Their research shows that a dietary supplement of vitamins C, natural vitamin E and beta carotene, along with zinc, lowers the chances of progressing to advanced AMD in certain at-risk people by about 25%. Daily supplements also reduced the risk of vision loss by about 19%.

The carotenoids lutein and zeaxanthin also help protect aging eyes. When scientists compared healthy eyes with eyes suffering from AMD, they found that AMD eyes contained lower levels of these vital nutrients (Ophthalmology 2003; 109:1780). Furthermore, they found that levels of these chemicals generally decline as you grow older.

Healthy at All Ages

When it comes to designing a healthy lifestyle, general rules like these can be followed, but you should individualize your plan to fit your needs. No matter which type of exercises you pick out or what healthy foods you choose, look for a strategy and a plan you can stick to. If you think a selection of foods are good for you but you absolutely hate their taste, chances are you won't be able to stick to a diet that includes them.

The same goes for exercise: Pick out activities that you enjoy and that you can perform consistently. That increases your chance of sticking to an exercise program.

Staying healthy is enjoyable and it helps you get more out of life every day, no matter what stage of life you're in.

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Vitanet ®

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Date: June 13, 2005 10:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...

Botanical Arsenal by Fred Thomas Energy Times, May 3, 1999

The complexities surrounding the various types of cancer stem from the variety of ways in which these diseases can wreak their havoc. Luckily, the equally complex world of plants contains novel compounds that can help our bodies fight off cancer's deadly progress.

Research Expands

Research into these botanical compounds is mushrooming. An example: The mighty maitake, a fungus with flair, alternately known as the king (it can grow as large as a basketball, worth its weight in silver to the ancient Japanese); the prince; the Hen of the Woods (it sticks out of from trees when it grows in the wild); and the dancing mushroom to those who leaped for joy when they found one growing in its native northeastern Japan.

Researchers today dub it with a new moniker: Herbal Heavyweight.

Mushroom with Potential

The maitake, with such other medicinal mushrooms as shiitake and reishi, historically has been eaten to promote general well-being and vitality. In the modern lab, however, scientists focus on the potent immune enhancing powers of maitake, which spotlight its cancer fighting potential.

Twenty years ago, maitake, Grifola frondosa, was an obscure, largely unavailable mushroom. A series of significant Japanese studies then catapulted it into prominence-and popularity.

Maitake Magic

Hiroaki Nanba, PhD, of the department of immunology at Kobe Women's College of Pharmacy on Kobe, Japan, and a leading international researcher on maitake, conducted the preliminary tests on the mushroom, demonstrating that it stimulates immune function and inhibits tumor growth.

In 1986, Dr. Nanba fed powdered maitake to mice injected with tumor cells; 86.3% displayed inhibited tumor growth.

Dr. Nanba and his colleagues went on to run additional mouse tests, finally reporting that this potent mushroom "directly activates various effector cells (macrophages, natural killer cells, killer T-cells, etc.) to attack tumor cells."

From then, maitake mushrooms were headed to fame as cancer ninjas.

Stoking The Immune Engine

Like other mushrooms, maitake is rich in complex polysaccharides, immunomodulators that successive tests after Dr. Nanba's have shown to be effective in cancer and AIDS treatment.

The polysaccharides in maitake have a unique structure, rendering them some of the most powerful to be studied (Chem Pharm Bull 1987:35:1162-8).

What makes maitake a particularly hot property is beta-D-glucan, its primary polysaccharide. Studies show that the body absorbs it readily, at which point it effectively stimulates interleukin-1, natural killer cells and macrophages, anti-tumor warriors that battle solid cancers (Chemotherapy 1990;38:790-6; also International Conference on AIDS, Amsterdam, 1992).

Effective And Safe

In addition to lab tests, trials on people have shown that maitake may offer powerful therapy against liver and stomach cancer (studies in China), breast and colon cancer (US research) and Kaposi's Sarcoma, the virulent cancer attacking AIDS sufferers.

Importantly, studies show that no side effects or interactions accompany maitake's efficacy.

Maitake fortunately has won the interest and enthusiasm of the scientific community. Currently, researchers at the Cancer Treatment Centers of America, headed by Denis Miller, MD, are completing an exhaustive test of the anticancer and immunostimulatory actions of maitake on folks with advanced colorectal cancer. These investigators hypothesize that the polysaccharide beta-glucans derived from the fruitbody of maitake fight tumors and boost immune function. "Though it cannot be said that maitake ...[is] the cancer cure," said Dr. Nanba in his closing remarks at the Adjuvant Nutrition in Cancer Treatment Symposium in Tampa, Florida, in October 1995, "one can safely say that they do maintain the quality of life of patients and improve the immune system, resulting in the possible remission of cancer cells with no side effects."

More Bodily Benefits

Maitake maven Dr. Nanba also has tested-with strongly positive results-the effect of maitake on blood glucose, insulin and triglycerides in mice, whose levels of all three substances declined when they were fed the mushroom (H. Nanba working paper, Anti-Diabetic Activity by Maitake Mushroom, 1994).

With colleagues, Dr. Nanba showed that maitake lowered blood pressure in hypertensive rats (Chem. Phann. Bu//36:1000-1006,1988). Other studies suggest it may accelerate weight loss.

This admirable adaptogen (meaning it helps the body adapt to stress and normalize its functions) is water soluble and may be eaten in food or taken as a supplement. Vitamin C is believed to intensify maitake's beta-glucans and enhance their absorption.

Tea Time

It's not just what you eat that may help protect against cancer, but what you drink as well. Research from China and Japan, where tea is the everyday drink and rates of several cancers like breast and prostate are lower, may persuade you to turn over a new leaf in your own beverage choice. One of the first studies to spark interest in tea came from Shanghai (Journal of the National Cancer Institute, June 1, 1994), where people who drank two to three cups a day were found to have about a 60% reduction in the risk of cancer of the esophagus. The reason: tea leaves contain compounds called polyphenols, potent antioxidants.

In fact, in tests at the University of Kansas, three of these, known as catechins, far outshone the common antioxidant vitamins C and E. Clinical trials are just starting, but early results are encouraging. A team of Chinese scientists reported that in a third of people with precancerous mouth sores who drank three cups of a mixture of green and black tea the lesions shrank significantly.

Researchers at the Saitama Cancer Center in Japan found that green tea seems to improve the prognosis of breast cancer. They followed a group of women with early-stage tumors for seven years. Those who drank more than five cups of green tea a day were only half as likely to suffer a recurrence as patients who consumed fewer than four cups a day.

Lung Help

And at the University of Indiana, toxicologist James Klaunig found that the lungs of cigarette smokers who drank the equivalent of six cups of tea a day suffered 40 to 50 percent less damage from the toxins in smoke, potentially lowering their risk of lung cancer and other pulmonary problems. Simultaneously, research from Purdue University suggests tea's cancer-discouraging powers go beyond being an antioxidant. Scientists Dorothy and D. James Morre showed that a tea catechin dubbed EGCG inhibits a growth-promoting enzyme on the surface of many cancer cells-happily without affecting normal cells. And researchers at the Ohio State University College of Medicine found that EGCG counteracted another enzyme, urokinase, that helps cancer cells spread. To top it off, Mayo Clinic scientists recently showed that EGCG prompted prostate cancer cells to commit suicide (Cancer Letters, Aug. 14, 1998).

Tea Research

So far, most tea research has Focused on green tea, and investigators agree it's more potent than the black tea most Americans favor. But because both kinds come from the same plant, Camellia sinensis (it's the processing that makes the difference as black tea is fermented, green tea isn't) both contain cancer-fighting polyphenols, just in different quantities. As long as the tea you drink (even decaffeinated) is fresh brewed, it's likely to provide some benefit; powdered and prepared teas probably don't. And adding milk may dilute the effect.

Astragalus Against Tumors

Astragalus, an herb commonly used in Asia to boost stamina, has impressed western doctors for its potential for helping people cope with chemotherapy. As John Diamon, MD, W. Lee Cowden, MD and Burton Goldberg point out in the Definitive Guide to Cancer (Future Medicine), "Astragalus appears to protect the liver against the harmful toxic effects of chemotherapy and may be effective in treating terminally ill liver cancer patients." (They cite a study in the Jrnl of Ethnopharmacology 1990, 30:145-149.) In addition, they point out, research in Japan supports using a ginseng-astragalus combination to improve the function of natural killer (NK) cells which can boost immunity (Japanese Jrnl of Allergy, 37:2, 1998, 107-114).

Other studies confirm astragalus' potential in fighting off cancer. Research at the General Hospital of PLA, Beijing, showed that flavonoids (pigments) in astragalus could help protect cell membranes from oxidative damage caused by ultraviolet exposure (Chung Kuo Chung Yao Tsa Chih, 21(12):746-8; 1996 Dec).

A study of laboratory animals at Cunma University in Maebashi, Japan, found that Astragalus could help preserve immune function against the harmful side effects of chemotherapy (Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(2):101-3, 1995 Feb).

Garlic Benefits

Like a flame attracting moths, garlic bulbs have irresistibly drawn the attention of medical researchers. A study at Aarhus University, Denmark, found that skin cells in laboratory dishes treated with garlic supplements lived longer, healthier lives than untreated cells (Jrnl Ethnopharm, 1994. 43:125-133).

Meanwhile, a long list of research demonstrates that garlic's phytochemicals may fight tumors and reduce the carcinogenicity of the pollutants and chemicals that assault us daily. A study in China reported in the American Journal of Chinese Medicine showed that garlic helped slow tumors in lab animals (1983, 11:69-73). Another study in the Journal of Nutrition found that compounds in garlic could "suppress the growth of human colon tumor cells" (126, 1355-1361).

Added to those benefits, Robert A. Nagourney, MD, reports in the Journal of Medicinal Food (1:1, 1998, 13-28), garlic may "modify the carcinogenicity of foodstuffs." In other words, studies show that garlic can make chemicals in foods like pork less likely to cause your cells to become cancerous. (Ind J Physiol Pharmacol, 39:347-353).

DNA Protection

DNA, the stuff that genes are made of, face constant threats from free radicals, caustic molecules that can alter cellular structure and possibly cause genetic mutations that lead to cancer. But research into what are called oligomeric proanthocyanidins (OPC), flavonoids (pigments) derived from fruits vegetables, grape seed extract and the bark of maritime pine trees shows that OPC may be able to shield DNA from injury.

In particular, studies of a grape seed extract called Activin have demonstrated this substance can help liver cell DNA escape a destructive process called peroxidation (FASEB, 11:3, 2/28/97).

In these experiments, Activin demonstrated the ability to inhibit the growth of tumor cells as well as slow the replication enzymes of HIV viruses. This protective ability proved to be more potent than that of vitamin C, beta carotene and vitamin E.

Future Promise

What does the future promise to reveal? Scientists believe that many unexamined plants probably contain undiscovered phytochemicals that hold great potential for helping us fight the cancer epidemic.

Certainly, if the next few years produce as many results as the past decade, the next millennium will witness a long line of cancer-prevention discoveries. Before long, you should be able to take advantage of these potent substances.

As you gulp your garlic, tip your tea cup, mull your maitake, acquire Activin and await your astragalus, you may meditate on what may soon be added to our growing anti-cancer arsenal. Undoubtedly, scientists with a botanical bent will be uncovering more coveted anti-cancer secrets before too long.

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Vitanet ®

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Date: June 13, 2005 10:23 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cancer at the Millenium - the war on cancer entering its third decade...

Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999

With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention.

Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones.

The Dietary Difference

Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism

The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff.

Carotenoid Characteristics

Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is masked by green chlorophyll).

Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers.

Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996).

Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements.

Unreserved Resveratrol

Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help.

Fat Chance

Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer)

Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116).

When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160).

Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances.

Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils.

Minerals to Lower Cancer Risk

n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium

In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96).

More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98).

Cruciferous Vegetables

Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748).

Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller.

Other researchers have Focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately.

Fiber

Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids.

This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many.

Fighting Breast Cancer

Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage).

Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen.

Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around.

A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue.

Novel Antioxidant

While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat.

But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals.

The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.

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Vitanet ®

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Date: June 13, 2005 10:06 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Recognizing the Signs: Roadmap to a Healthy Heart

Recognizing the Signs: Roadmap to a Healthy Heart by Louis McKinley Energy Times, January 2, 2004

From time immemorial, people have tuned into life's lessons that come from the heart. Sadly, times are changing: If you're like most inhabitants of today's harried world, you may be too distracted to detect important clues about your cardiovascular circumstances.

And while heart lessons may be more complicated than simply connecting the physiological dots, understanding those heart messages are imperative for improving and maintaining your heart health.

Every cell in your body relies on heart-powered blood flow to keep it supplied with nutrients, oxygen, hormones and other natural chemicals necessary for survival. Without that supply of life-giving substances, few cells in the body-including those within the heart itself-can survive very long.

And just as damage to a major roadway can cause mayhem with traffic patterns, damage to blood vessels and the heart can wreak a lumpy cardiovascular havoc that blocks the passage of blood and endangers your heart's well-being.

Your Heart Disease Chances

Within the last ten years, scientific research performed by investigators around the world has Focused on the specific factors that most strongly influence your chances of developing heart disease and suffering either a heart attack or a stroke.

While much of your risk depends on your genetic inheritance and family history, several factors that determine your heart health are within your control.

The most important factors you can do something about include:

* Smoking: free radicals generated by burning tobacco causes significant damage to blood vessels and other cells

* Lack of exercise: the human body is designed for consistent, moderate physical activity; without exercise, the body slacks off in creating antioxidant protection for arteries

* Diabetes: when excess blood sugar persists, physiological processes begin that endanger the heart and arteries

* Cholesterol: when oxidized (a chemical process that has been compared to a kind of internal rusting), cholesterol can form artery-blocking plaque; antioxidant nutrients like vitamin C and natural vitamin E may help the body limit this process

* High blood pressure: excessive pressure within the blood vessels raises the risk of damage to the heart and arteries; a program of weight loss and exercise can help control blood pressure

* Being overweight: the extra body fat carried around your middle is linked to a greater risk of heart problems

Heart Attack Signs

Do you think you know what a heart attack feels like? Well, if you think it feels like a dramatic pain somewhere in your chest that knocks you to the floor, you're probably wrong. "Most heart attacks do not look at all like what one of my colleagues calls the 'Hollywood' attack-the heart attack you see on television or in the movies," warns Julie Zerwic, MD, professor of surgical nursing who has studied what happens when people develop heart disease and suffer damage to their hearts.

"The symptoms [of heart problems] are not necessarily dramatic. People don't fall down on the floor. They don't always experience a knife-like, very sharp pain. In fact, many people describe the sensation as heaviness and tightness in the chest rather than pain," she says. And, if you're a woman experiencing a heart attack, you may not even feel discomfort specifically in your chest. Instead you may experience a severe shortness of breath. The apparent ambiguity of the discomforts caused by a heart attack lead many people to either ignore them or take hours to realize they need to go to the emergency room at the hospital.

Consequently, much fewer than half of all individuals undergoing a heart attack actually go to a hospital within an hour of the start of the attack. That delay can be a fatal mistake.

"Timing is absolutely critical," laments Dr. Zerwic. "If treatment starts within a hour after the onset of symptoms, drugs that reestablish blood flow through the blocked coronary artery can reduce mortality by as much as 50%. That number drops to 23% if treatment begins three hours later. The goal is to introduce therapy within two hours."

However, in Dr. Zerwic's research, only 35% of non-Hispanic whites go to the hospital within an hour of the start of a heart attack. And among African-Americans, the number of people going to the hospital right away drops to a frighteningly low 13%.

Often, people will lie down or use a heating pad to relieve the tightness they feel in the chest," says Dr. Zerwic. "They may take some medicine and wait to see if that works. All these steps postpone needed treatment."

Signs of a possible heart attack include:

* Chest discomfort: Heart attacks most frequently cause discomfort in the center of the chest that can either go away after a couple of minutes (and come back) or persist. The discomfort may feel like strong pressure, fullness or pain.

* Upper body discomfort: An attack may set off pain or discomfort in either or both arms, and/or the back, neck, jaw or stomach.

* Shortness of breath: Chest discomfort is frequently accompanied by shortness of breath. But it's important to note that shortness of breath can take place even in the absence of chest discomfort.

* Other signs: You can also break out in a cold sweat, or feel nauseated or light-headed.

A Woman's Sleep Signs

If you are a woman who suddenly experiences a marked increase in insomnia and puzzling, intense fatigue, you may be in danger of an imminent heart attack.

In an attempt to understand how women's symptoms of heart problems differ from those of men, researchers talked to more than 500 women in Arkansas, North Carolina and Ohio who had suffered heart attacks. (Technically, what they had experienced is referred to as acute myocardial infarction.)

They found that chest pain prior to a heart attack was only reported by about 30% of the women surveyed.

More common were unusual fatigue, sleep disturbances and shortness of breath (Circulation Rapid Access, 11/3/01).

"Since women reported experiencing early warning signs more than a month prior to the heart attack, this [fatigue and sleep problems] could allow time to treat these symptoms and to possibly delay or prevent the heart attack," says researcher Jean C. McSweeney, PhD, RN, nursing professor at the University of Arkansas for Medical Sciences in Little Rock. In Dr. McSweeney's study, more than nine out of ten women who had heart attacks reported that they had had new, disturbing physical problems more than a month before they had infarctions.

Almost three in four suffered from unusual fatigue, about half had sleep disturbances, while two in five found themselves short of breath.

Other common signs included indigestion and anxiety.

"Women need to be educated that the appearance of new symptoms may be associated with heart disease and that they need to seek medical care to determine the cause of the symptoms, especially if they have known cardiovascular risks such as smoking, high blood pressure, high cholesterol, diabetes, overweight or a family history of heart diseases," says Dr. McSweeney.

Dr. McSweeney warns that, until now, little has been known about signs that women are having heart trouble or heart attacks. The fact that most of Western medicine's past attention has been on heart problems in men has obscured the warning signs in women. As part of Dr. McSweeney's studies, she and her fellow researchers have discovered that more than 40% of all women who suffer a heart attack never feel any chest discomfort before or during the attack.

"Lack of significant chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments," she notes. "Many clinicians still consider chest pain as the primary symptom of a heart attack."

Vitamins for Diabetes and Heart Disease

Having diabetes significantly raises your chance of heart disease, which means that keeping your blood sugar levels under control can reduce your chances of suffering a heart attack.

Today, 17 million Americans have diabetes and, as the country's population in general gains weight and fails to exercise, the number of people suffering this problem continues to grow.

The first line of defense against diabetes consists of exercise and weight control. All you have to do is take a brisk walk for 30 minutes a day to drop your chances of diabetes (American Journal of Epidemiology 10/1/03).

"We have found that men and women who incorporate activity into their lifestyles are less likely to develop type 2 diabetes than those who are sedentary. This finding holds no matter what their initial weight," said Andrea Kriska, PhD, professor of epidemiology at University of Pittsburgh Graduate School of Public Health.

To help your body fight the development of diabetes, researchers also recommend vitamin C and natural vitamin E.

Researchers working with lab animals at the University of California at Irvine have found that these antioxidant vitamins can help insulin (the hormone-like substance secreted by the pancreas) reduce harmful blood sugar. In addition, these vitamins shrink the chances of organ damage that can be caused by diabetes (Kidney International 1/03).

In this investigation, these vitamins also helped reduce blood pressure, another risk factor that raises heart disease risk.

"Blood pressure was lowered to normal, and free radicals were not in sufficient numbers to degrade the sugars, proteins and nitric oxide," notes Nick Vaziri, MD, professor of medicine at the University of California. "We think this shows that a diet rich in antioxidants may help diabetics prevent the devastating cardiovascular, kidney, neurological and other damage that are common complications of diabetes."

Free Radical Blues

Dr. Vaziri and his group of researchers found that untreated diabetes raised blood pressure and increased the production of free radicals, caustic molecules that can damage arteries and the heart. Free radicals can change blood sugar and other proteins into harmful substances, boosting tissue and heart destruction.

In Dr. Vaziri's work with lab animals, he found that treating diabetes with insulin lowered blood pressure and helped keep sugar and protein from changing into dangerous chemicals, but allowed the free radicals to subvert nitric oxide, a chemical the body uses to protect itself from free radicals.

In this investigation, adding vitamins C and E to insulin insulated the body's sugars, proteins and nitric oxide from oxidative assault. This produces a double advantage: Lowering the risk of heart disease and other damage to the body from diabetes.

Maitake, an Oriental mushroom that has been shown to have many health benefits, can also be useful for people with diabetes who are trying to avoid cardiovascular complications. Laboratory studies in Japan demonstrate that maitake may help lower blood pressure while reducing cholesterol (Biological & Pharmaceutical Bulletin 1997; 20(7):781-5). In producing these effects, the mushroom may also help the body reduce blood sugar levels and decrease the risk of tissue damage.

No Smoking!

Tobacco smoke is one of the most notorious causes of heart problems. In the same way a hard frost exerts a death grip on a highway, the smoke from cigarettes can freeze up arteries and hamper their proper function. A healthy artery must stay flexible to comfortably allow adequate circulation.

But "...when blood vessels are exposed to cigarette smoke it causes the vessels to behave like a rigid pipe rather than a flexible tube, thus the vessels can't dilate in response to increased blood flow," says David J. Bouchier-Hayes, MD, professor of surgery at the Royal College of Surgeons in Ireland, who has studied the deleterious effects of tobacco.

This rigidity is called endothelial dysfunction. When arteries are rigid, blockages gum up vessels, clots and other impediments to blood flow appear, and your risk of heart attack and stroke increases (Circulation 2001 Nov 27; 104(22):2673).

This condition can also cause chest pain (angina) similar to that caused by a heart attack, and should be evaluated by a knowledgeable health practitioner.

Although all experts recommend you stop smoking to lower your heart disease risk, some studies have found that Pycnogenol(r), a pine bark extract that helps the body fight inflammation, may ease some of smoking's ill effects.

In a study of platelets, special cells in the blood that can form dangerous blood clots, researchers found that Pycnogenol(r) discouraged platelets from sticking together (American Society for Biochemical and Molecular Biology 5/19/98). By keeping platelets flowing freely, this supplement may alleviate some of the heart-threatening clots that tobacco smoke can cause.

In Ayurvedic medicine, a traditional therapy from India, an herb called guggul has also been used to lower the risk of blockages in arteries. This herb, derived from the resin of the mukul tree, has been shown to reduce cholesterol by about 25%. People taking this herb have also reduced their triglycerides (harmful blood fats) by the same amount (Journal Postgraduate Medicine 1991 37(3):132).

The Female Version of Heart Disease

These types of risks have motivated industry groups to urge more regulation of GMO crops. The Food Marketing Institute, the Grocery Manufacturers of America (GMA) and the National Restaurant Association, plus seven other food groups, are worried that GMO plants grown to produce pharmaceutical drugs could contaminate the food supply and destroy consumer trust in food.

Mary Sophos, a vice president of GMA, warns, "To minimize the possible risks, a clear system of regulatory enforcement and liability needs to be in place. Until then, no permits for new field trials or for commercialization should be issued because there is no room for trial and error."

These food industry groups have voiced their concerns to the Food and Drug Administration (FDA) and the USDA. Last year, the USDA forced ProdiGene Inc., a biotech firm, to dispose of 500,000 bushels of soybeans contaminated with a drug meant to treat diabetes. What are the chances of more GMO accidents? No one knows. But if you buy and eat organic, you minimize your risk and maximize your chances of dining on safer food.

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Vitanet ®

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Date: June 11, 2005 04:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Joints Are Jumping

The Joints Are Jumping by Rachel Alexander Energy Times, October 8, 2003

It usually starts with a twinge in your back or an ache in your knees: Knee stiffness, back pain and joint inflammation can signal the beginning of arthritis.

According to the US Food and Drug Administration, arthritis affects over 42 million Americans-that's 1 in every 3 adults-and costs the economy nearly $65 billion annually. But as common as arthritis is, it doesn't have to extract a high cost from your joints.

Who's At Risk?

Arthritis literally means an "inflammation of the joints" and can affect anyone-from small children to 80-year-olds. Some groups are more prone to certain types of arthritis; for instance, those over 40 are at greater risk for developing osteoarthritis, a degenerative condition of the joints.

According to Johns Hopkins Medical Institute, more than 50% of all individuals over the age of 40 have x-ray signs of osteoarthritis in weight-bearing joints (such as those in the knees and hips), and nearly half of those over 65 have measurable symptoms of arthritis. Osteoarthritis is often caused by overuse, age, excess weight or genetics, or by a combination of these factors.

Rheumatoid arthritis, on the other hand, is a disease of the immune system that affects the joints, which can make it harder to diagnose because early symptoms-fatigue, weakness, loss of appetite and low-grade fever-can mimic other chronic conditions.

Stiffness and pain may or may not accompany the initial symptoms of rheumatoid arthritis. However, joints eventually become inflamed and swollen. Although less common that osteoarthritis, rheumatoid arthritis affects more than 2 million Americans.

Covering Up the Signs

Treating arthritis can involve the use of both conventional and non-conventional therapies.

"In osteoarthritis specifically, conventional medicine has just been Focused on covering up the symptoms," says Jason Theodosakis, MD, author of The Arthritis Cure (St. Martin's Press). "In the history of medicine, this approach has been considered primitive."

But Dr. Theodosakis points out that treatment often depends on the type of arthritis involved: "Rheumatoid arthritis patients should be taking prescription drugs that are known to prevent the disease from progressing. [Use] alternative medicine as an adjunct..."

Conventional therapies often involve the use of non-steroidal anti-inflammatory (NSAID) medicines, such as ibuprofen and naproxen. The chief drawback of NSAIDs is the toll these treatments extort from the gastrointestinal system.

In fact, a 2002 study conducted by researchers at the University of South Florida, Tampa, found that more than 15% of patients developed digestive problems after a five-week course of ibuprofen. In addition, ibuprofen may increase blood pressure.

Newer prescription NSAIDs called COX-2 inhibitors, which work by suppressing the body's inflammatory response, also carry risks of side effects ranging from diarrhea and fluid retention to liver damage and kidney problems. In addition, people with asthma or chronic allergies (including to aspirin) should not take these medicines.

Corticosteroids-another treatment option that has been used to lessen inflammation-can cause side effects such as increased appetite, mood changes and even immune system breakdown.

Natural Answers

A growing body of evidence shows that nutrients such as glucosamine and MSM, coupled with lifestyle changes, can help decrease or eliminate some of the aches and pains of arthritis. Glucosamine is a natural chemical that helps build joints. When the cartilage in joints deteriorates due to age or other factors, studies indicate that glucosamine provides the necessary building blocks for rebuilding and repairing this tissue.

In one investigation (Archives of Internal Medicine 2002; 162:2113-23), scientists discovered that glucosamine slowed the progression of osteoarthritis and improved symptoms for over 200 patients. Another study, conducted by researchers in the Netherlands, demonstrated that a combination of glucosamine and chondroitin holds promise for conditions such as spinal disc degeneration.

To date, several studies have confirmed glucosamine's ability to help the symptoms of arthritis, and the National Institutes of Health is currently supporting research to further study the benefits of glucosamine.

Other Joint Aids

MSM is often an adjunct therapy as it does not work directly on joints, but provides the raw materials, in this case sulfur, to help rebuild cartilage in the joint matrix. Studies indicate that sulfur has a protective effect and may interact with magnesium, an essential bone nutrient.

Traditionally, the herb horsetail (Equisetum arvense) has been used to supply silica, a mineral component of nails, bones and joints. Its support of these structures can help in the fight against arthritis.

As the body ages, it may lose much of its silica reserves. Resupplying much of this mineral may help support joints. In addition, experts believe, silica can help the body use calcium more effectively and support bone health.

Since rheumatoid arthritis is a systemic affliction, you should work with a trained health professional in treating it. Complementary care practitioners often use antioxidant nutrients, such as vitamins C and E, to reduce free radical damage, along with pantothenic acid (vitamin B5) to lessen morning stiffness.

A Joint Project

According to Dr. Theodosakis, exercise is the key to dealing with arthritis: "[Start with] an individualized exercise program that strengthens the joints without causing more damage...and an eating program to control your weight if you are currently overweight." To limit the effects of arthritis, you should quit smoking, since smoking generates free radicals that can harm the tissues which make up joints. In addition, a strict vegan diet may help alleviate some of the pains of rheumatoid arthritis.

Dr. Theodosakis also recommends looking for hidden causes of symptoms, such as food allergies, that may contribute to arthritis.

Heat helps ease arthritis pain and encourages both blood flow and tissue repair. A plain, old-fashioned hot water bottle works quite well. Or you can use one of the newer heat-generating wraps, which are thin enough to be worn under clothing and don't have to be constantly reheated.

You can't always avoid arthritis, especially as you get older. But you don't have to let it get the better of you.

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Date: June 10, 2005 03:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Maximum Absorption

Maximum Absorption

by Henry Wolfe Energy Times, July 11, 2003

Nutrients do you no good if you don't absorb them. Eating the right stuff and taking the right nutrients can still be wrong if they never make it out of your digestive tract and into your bloodstream.

For instance, dietary supplements usually should be taken along with food. The presence of food in the digestive tract aids the absorption of nutrients. As a general rule, if you take dietary supplements on an empty stomach, most of their contents will probably pass through you and never escape your intestinal tract before they are eventually eliminated. This is particularly true for the fat-soluble nutrients such as vitamins A, D and E. By consuming fatty foods when you take these supplements, you enable your body to absorb a large amount of these valuable substances.

But there is at least one exception to this rule: Amino acid supplements (protein building blocks) should usually be taken on an empty stomach. Otherwise the other amino acids present in your meal may interfere with your use of these nutrients and counteract the benefits of the supplements.

The Standardization of Herbs

Taking herbs presents different challenges than consuming dietary supplements. While the chemical structures of nutrients in supplements are usually precisely identified, the active ingredients in herbs is usually a mixture of chemicals. Often, too, researchers disagree on exactly which active ingredients in herbs produce the health benefits linked to these botanicals.

But in an effort to derive the most from these substances, many experts recommend what are called standardized forms.

Standardized herbal supplements are formulas that have been created to insure they contain consistent and reliable amounts of certain beneficial chemicals that scientists have identified in these plants.

In the creation of these supplements, experts determine the standardized chemicals that are most likely the basis of the herbs' effectiveness.

By standardizing certain of the supplements' ingredients, therefore, standardized herbs limit the variation among batches of the product. You can rely on the fact that every purchase will contain the same amount of ingredients taken from the original plant. According to Michael Janson, MD, author of Dr. Janson's New Vitamin Revolution (Penguin/Avery), "Although herbs have a long history of use for medicinal purposes, it is only recently that they have been analyzed to reveal their most active components. These active chemicals are commonly present in very variable amounts in herbs, depending on where and how they are grown, soil quality, when they are harvested, the amount of rain and sun, and other factors.

"Standardized herbs have guaranteed specific amounts of the known, active herbal components, as well as the other factors that might be of help but are not as well studied" (www.drjanson.com).

Herbalists who specialize in using entire plants in their practices can recommend non-standardized preparations that you can often use.

In general, that kind of herbal use is more effective when you secure expert advice. If you lack access to an experienced herbalist and you're choosing botanicals on your own, standardized preparations are easier to take.

Absorption From the Gut

Most of the nutrients you take in are absorbed through the walls of your digestive tract. This most often takes place in the small intestine.

What to watch out for: Fast food, fast living and long work hours afflicts our digestion and can disrupt proper absorption. You have to be relaxed to properly absorb the nutrients in your food and supplements.

Consequently, the occasions for meals should be relaxed and enjoyable moments. Set aside enough time to appreciate, taste and thoroughly chew your food. Adequate digestion and absorption begin in your mouth.

Another way to increase nutrient absorption is with the use of digestive enzymes. Since the digestive tract depends on the enzymatic breakdown of food that reduces nutrients to absorbable form, taking enzymes can help your intestines make better use of nutrients as they pass through the digestive tract. Normally, enzymes are present in raw food, like uncooked fruits and vegetables. Since most of our food is eaten after it is heated, a process that breaks down enzymes, not many enzymes are present in today's diet. Therefore, taking supplemental enzymes may increase absorption.

Beyond Stress

Beyond everyday stress, a variety of problems can make absorption go astray, allowing important nutrients to escape and permitting unwanted substances to enter the body. For instance, a significant digestive malfunction that many experts have Focused on in recent years is a condition that has come to be called "leaky gut."

As Anil Minocha, MD, director of digestive diseases at the Mississippi Medical Center and author of Natural Stomach Care (Avery), points out, "In a healthy individual, the wall of the intestinal tract is designed to absorb food molecules and prevent harmful microorganisms and toxic materials from passing out through the bowel wall and into the bloodstream. "In today's heavily polluted environment, the gastrointestinal tract of even the healthiest individual is called on to process an overwhelmingly large flow of septic and infectious materials."

Because of these digestion destroyers, as we take in a startlingly large amount of viruses, bacteria, toxic chemicals, fungi and processed foods, our digestive systems are often overwhelmed and are rendered unable to perform their tasks correctly. This constant assault on the stomach and intestines takes a serious toll. A frequent product of this process is the digestive walls' loss of their crucial ability to keep out unwanted toxins and organisms as they become, in Dr. Minocha's words, "loosened and inflamed." As a result, instead of keeping out harmful substances and absorbing helpful nutrients, spaces open up that begin to allow in "bulky, partially digested food particles, toxic substances and infectious microbes."

According to Dr. Minocha, the first signs of this absorption problem can include complaints such as allergic reactions, skin problems, joint pain, digestive difficulties, nausea, fatigue and lack of energy.

To improve your digestive absorption, Dr. Minocha recommends a six-part program that includes these steps:

* Detoxification by means of fasting and avoiding harmful items like sugar, over-processed foods, coffee and alcohol

* Taking herbs that can help the digestive tract heal, recover and repair itself; these include garlic, ginger and milk thistle

* Replenishing the beneficial bacteria of the digestive tract by eating yogurt

* Keeping track of your daily diet and eliminating foods that cause allergies and other reactions

* Consuming more fruits and vegetables while eating a high-fiber, mostly vegetarian diet

* Developing consistent, healthy lifestyle habits; these include not smoking, cutting the size of your meals and eating in moderation, exercising several times a week and controlling stress

Young and Old Digestion

The nutrients in your diet can also beneficially influence the state of your digestive system and its ability to distinguish among substances that are supposed to gain entrance to your body and those that should be kept out. Since aging can further compromise the discriminatory ability of your gut, Dr. Minocha also recommends a steady diet of antioxidant-rich fruits and vegetables plus supplements to keep your digestive tract functioning at full capacity as you grow older.

Among the nutrients he recommends:

* Coenzyme Q10: By middle age, your body makes less of this powerful antioxidant that helps cells generate energy in the mitochondria (structures within cells that may decrease with age).

Dr. Minocha notes that research demonstrates CoQ10 may be able to help people with diabetes control harmful metabolic byproducts that appear in their bloodstreams.

* Natural Lycopene: This antioxidant, responsible for the red of both tomatoes and watermelon, has been shown to lower the risk of both heart disease and prostate cancer. As an antioxidant, natural lycopene also helps protect the digestive tract.

Absorption of the proper nutrients may be the key to health for many people. By paying closer attention to the well-being of your digestive tract and practicing lifestyle habits that promote maximum absorption, you may be able to substantially improve your nutrition and your health.

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Date: June 10, 2005 01:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Holy Basil Extract - Promotes Centered Calmness

Holy Basil Extract

This Product (known as tulsi in Ayurveda) is one of the primary botanicals used in India for reducing the negative effects of stress by lowering cortisol production in the adrenals. In vitro research shows the ursolic acid in this product inhibits COX-2, an inflammatory enzyme. As a powerful adaptogen, it helps maintain normal blood sugar levels when used as part of your diet, as well as promote Focused clarity.

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Date: June 09, 2005 05:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Kyolic Garlic - Aged Garlic Extract May Help Manage Diabetes

Aged Garlic Extract May Help Manage Diabetes Recent tests already show hope that aged garlic extract can prevent damage to eyes, kidneys, blood vessels and skin

Can aged garlic extract really help diabetics preserve their vision? People who have diabetes often suffer from damage to their eyes, kidneys, blood vessels and skin. This is caused by high sugar levels in a process called glycation. Researchers at Manchester University in England have already shown that garlic, in liquid form, may be a potent block on glycation in the lab. Now the same researchers will study the effect of liquid Kyolic® Aged Garlic Extract in a clinical trial involving 70 patients with Type 2 diabetes, the most common form of diabetes.

The researchers are looking at whether a natural product can help prevent diabetes or play a role in the treatment of the disease. "One of the other things that people with diabetes have is increased free radical activity which could have a role in these complications," said Dr. Nessar Ahmed, molecular biologist at the university's department of biological sciences. Aged garlic extract's antioxidant compounds fight free radicals which damage healthy cells, and have been widely studied.

Aged garlic extract is produced by a long extraction process, up to two years, creating an odorless product rich in active, bioavailable compounds. This extract is standardized to ensure consistent levels and ratios of these unique compounds. In fact, some of these beneficial compounds are not found in regular raw garlic or other garlic supplements.

More than 375 scientific studies have been completed on aged garlic extract, done in major universities and research centers. These studies have Focused on various aspects of garlic's health benefits including the reduction of multiple risk factors such as cholesterol and high blood pressure lowering effects; homocysteine control; inhibition of LDL oxidation (reducing sticky cholesterol); blood-thinning effect; and stimulating blood circulation by widening blood vessels. In addition, other aged garlic extract research has concentrated on immune enhancement, improving memory (prevention of Alzheimer's), protecting liver function and anti-cancer effects.

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Date: June 09, 2005 05:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk

Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk Factors Presented at the 2005 World Garlic Symposium at Georgetown

Garlic has been used medicinally for thousands of years. Past research has established the significance of garlic and its healthful benefits. Recently new metabolic roles for garlic were presented at the symposium, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease” which was held at the Georgetown University Conference Center on April 9-11, 2005.

The conference brought together the world’s top authorities in various fields of garlic research to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states such as cancer.

One of the highlight presentations was on the biggest study ever conducted in the history of garlic supplementation, a 7 year long clinical study. The study was undertaken to determine aged garlic extract effects on stomach cancer and serous digestive problems that can lead to gastric cancers. It was performed through collaboration of National Cancer Institute (NCI) and leading Chinese researchers, who tested to see if aged garlic supplementation would significantly effect or reduce precancerous gastric lesions. The clinical study was double-blinded and randomized, with over 3,000 human subjects. It was led by Dr. Mitchell Gail at NCI and Dr. Wei-Cheng You at the Beijing Institute for Cancer Research.

Preliminary results of this study showed that people with the highest intake of allium-containing vegetables, like aged garlic, had only 40% of the risk of gastric cancers as those who rarely ate them.

Also from the Chinese study was another surprising finding: when researchers used aged garlic extract in combination with antibiotics to treat people with precancerous stomach lesions caused by the Helicobacter pylori bacteria, 76% were completely healed. “It’s a very large and long-term study. We’re still sifting though the data, but we expect to report on it by the end of this year,” said Dr. Gail.

Another surprising presentation showed the results of several colon cancer studies reported from both Osaka and Hiroshima University in Japan. These studies clearly showed that the addition of aged garlic extract to cancer treatment was beneficial to colon cancer patients. Researchers found that those who consumed aged garlic extract experienced a reduction of the size and prevalence of tumors.

“Aged garlic extract has well-known antioxidant properties. The aging process eliminates garlic breath as well as those harmful properties, leaving only the antioxidants that protect against disease,” said cancer symposium chairperson and lead UCLA researcher David Heber, M.D.

Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have Focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects.

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Date: June 09, 2005 05:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

The Latest Breakthroughs in Garlic Research

on Cancer and Cardiovascular Disease

Presented at the 2005 World Garlic Symposium

Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

Presentation highlights included:

Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.

“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have Focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

Abstracts

PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

Bibliographies

David Heber, MD, PhD, FACP, FACN

Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

Matthew Budoff, MD, FACC

Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.

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Date: June 02, 2005 01:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lutein 6mg, 20mg, help stop macular degeneration ...

Lutein

One of the more surprising discoveries of modern nutritional science is that the very pigments which give brilliant color to our fruits and vegetables are powerful nutrients which can protect us from the rigors of time and environment. Lutein is one of the most recent discoveries in this field. In our diets, it’s found most abundantly in dark green leafy vegetables such as spinach, collards and kale. Like beta-carotene, lutein is a powerful antioxidant which studies show can contribute to the protection of cells. But the most promising application of lutein may be its beneficial influence on the eyes, particularly in regard to macular degeneration. Source Naturals LUTEIN is a concentrated source of this important natural nutrient.

Like the beta-carotene that makes carrots orange and the lycopene that makes tomatoes red, lutein is a carotenoid. It is the pigment that makes corn yellow, and gives marigolds their brilliant golden color. One of the most interesting aspects of the way carotenoids interact with the human body – beyond their broad spectrum antioxidant activity – is their tendency to be “organ specific.” Different carotenoids have an affinity for different organs in the body. In the case of lutein, it is found concentrated in the structure of our eyes.

Vision and Macular Health

The process of vision involves light being Focused through the lens and onto the retina, the paper-thin tissue lining the back of the eyeball. The central portion of the retina, called the macula, receives the most light. Its millions of cells produce the sharp vision needed to read and see objects clearly. With age, tiny blood vessels grow over this area, causing a gradual distortion and loss of vision. This degeneration of the macular region of the retina is the leading cause of irreversible visual impairment in the USA today. It affects almost 20% of people past the age of 65. Research has shown that these people have lower than normal amounts of macular pigment, which suggests the protective role played by these pigments. In fact, the latest research suggests that low levels of macular pigment is a cause, rather than a result, of macular deterioration.

Lutein – The Eyes Have It

Lutein and another carotenoid called zeaxanthin are the most dominant pigments in the macular region of the retina. (Source Naturals LUTEIN contains 5-7% zeaxanthin.) Their antioxidant properties help maintain the integrity of the blood vessels that supply the macular region of the retina: providing protection from photo-oxidation, the result of light striking the fatty acids in the retina. It seems that lutein is particularly active against the blue part of the spectrum, which can be the most damaging to our eyes. One study using lutein supplements resulted in a 15% increase in macular pigment levels after 72 days. In another study, people who consumed the equivalent of 6 mg of lutein per day were 40% less likely to experience macular problems. Another study using sets of identical twins demonstrated that macular lutein concentrations were related to dietary lutein. After consumption, lutein is found in significant quantities in blood serum, suggesting high bioavailability.

Our Connection with Plants

In this era of biochemistry, we’re rediscovering our vital connection with plant life. Although research into phytonutrients is relatively new, many plant compounds are being found in significant concentrations in the human body. Their presence in our blood serum, organs, and mothers’ milk suggests they play an important role in our body chemistry, and perhaps explains why we’ve appreciated them as foods throughout history. Like many carotenoids, lutein has evolved as an integral part of human biochemistry, with many benefits to our well-being. Since mammals cannot synthesize it, lutein must be obtained from the diet. Source Naturals LUTEIN is extracted from specially grown marigold flowers high in Lutein, and purified by an exclusive patented process. So the next time you bathe your eyes in a golden bouquet of marigolds, remember their beauty really is in the eye of the beholder.

References

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Date: June 01, 2005 12:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Diet Phen - Dietary Supplement and weight Loss ...

Diet Phen for weight Loss

Getting slim, trim and fit is no easy task. To do it you need adequate Energy, Nutritional and Emotional Support, and a Positive Attitude. Source Naturals puts them all together in the DIET-PHEN Weight Loss Plan. The plan includes an herbal-safe nutrient formula that combines optimal amounts of St. John’s wort with synephrine and green tea extract, plus L-phenylalanine and chromium. Meet your weight loss goals the natural way. Try Source Naturals DIET-PHEN dietary supplement in conjunction with the Diet-Phen Weight Loss Plan.

THE PLAN HELPS TO:

DIETING – It Starts in Your Head.

Successful dieting depends on the right mind-set: you need a positive outlook and determination. When your head is in the right place, your body may follow. That’s why the DIET-PHEN Weight Loss Plan includes natural herbs and amino acids to help support a sense of active calm.

ST. JOHN’S WORT – The CenterPeace of DIET-PHEN. In use since ancient times, Hypericum perforatum is a flowering herb highly valued for its positive influence on mental well-being. Known for its soothing effect, it seems to promote relaxation without drowsiness. Recent research has Focused on the connection between hypericin (the principal phytochemical in St. John’s wort) and serotonin, a key neurotransmitter associated with mood. About 90% of your serotonin receptors are found in your brain’s emotional center, the limbic system.

SYNEPHRINE, GREEN TEA AND L-PHENYLALANINE – Energize with an Attitude! Synephrine and green tea extract are added for that extra energy needed during dieting. The brain uses phenylalanine to manufacture dopamine and norepinephrine, two neurotransmitters that play an important role in drive and determination.

ACETYL L-CARNITINE – Transporting Fat to the Furnace. Within each of your trillions of cells are thousands of tiny energy factories called mitochondria. They convert fats and sugars into metabolic energy. Acetyl L-carnitine supports this process by transporting fat molecules to the mitochondria.

THE PLAN INCLUDES A DAILY SERVING OF 3 DIET-PHEN TABLETS TO PROVIDE:

GET STARTED WITH THE PLAN ! Get DIET-PHEN dietary supplements and the Weight Loss Plan at VitaNet health food store.

REFERENCES:

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Date: June 01, 2005 09:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Calm Thoughts Kava - from Source Naturals

Calm Thoughts

Stress: it disturbs your serenity. Ultimately it takes a physical toll on your health. And it seems to be an unavoidable part of the hectic modern lifestyle. Source Naturals CALM THOUGHTS KAVA is a comprehensive formula designed to help you stay calm in the face of stress and anxiety—without sacrificing the clarity and focus you need to function effectively. CALM THOUGHTS is centered around a standardized extract of kava kava, the relaxing herb of choice for generations of South Pacific Islanders. But CALM THOUGHTS goes further, with soothing herbs and nutrients, rejuvenating ingredients and neurotransmitter support.

Soothing Herbs

CALM THOUGHTS is centered around the renowned calmative kava kava. Used for generations by South Pacific Islanders, kava is known traditionally for its ability to help a person achieve a tranquil, meditative, yet Focused state. Kava is an integral part of the spiritual and social fabric of Pacific Islanders’ life, used to help people relax and socialize. In Europe, where kava has been the subject of a number of double-blind, placebo-controlled clinical trials, science has confirmed its beneficial effects, and made kava a popular alternative for reducing stress. Those studies found reduced anxiety levels in individuals given standardized kava extracts. CALM THOUGHTS enhances kava’s calming properties with a number of supporting herbs. One of these is bacopa, known commonly as Brahmi in Indian herbalism and used extensively as a nervous system tonic. The formula also includes St. John’s wort, the most extensively studied herb in the market today, and the well-known calmatives lemon balm and valerian.

Rejuvenating Factors

Several of the botanicals in CALM THOUGHTS are tonic herbs, helping to promote overall well-being. These include the adaptogens schizandra, ashwagandha and Siberian ginseng, all of which help the body deal with external stresses. Also featured are warming ginger, energizing licorice, and Ginkgo biloba, to promote circulation.

Neurotransmitter Support

CALM THOUGHTS includes ingredients which influence brain neurotransmitters involved in the body’s reactions to stress. GABA is an inhibitory neurotransmitter which may have regulatory effects on the nervous system. Tyrosine is a precursor to the catecholamines norepinephrine and dopamine, which play an important role in mood balance and may have a role in emotional feelings and behavior. Dopamine is a precursor to norepinephrine, an “activating” type neurotransmitter which is involved with attention, arousal, the sleep-wake cycle, and appetite regulation.

Supporting Nutrients

CALM THOUGHTS contains a range of vitamins, minerals and amino acids. Calcium is essential for the healthy functioning of nerves and muscles. Magnesium is mildly relaxing to the muscles, while taurine modulates certain nerve impulses. Vitamins C and B-5 are important for healthy functioning of the adrenal glands and help in the body’s response to stress. Vitamin B-6 is important for healthy functioning of nerves and aids in the metabolism of tyrosine and taurine. For calmness with clarity and focus, choose Source Naturals CALM THOUGHTS KAVA. This groundbreaking formula is available in 45 and 90-tablet bottles.

References

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VitaNet®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=127)

Date: May 19, 2005 09:29 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: KudZu, Treatment of alcohol dependence or alcohol abuse

For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.

Alcohol abuse

Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.

While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.

Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies Focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:

CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH

In addition, our studies more recently have Focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:

CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH

Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).

Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.