Search Term: " KETO "
Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine
July 27, 2023 12:12 PM
What if there existed a form of thiamine that was more bioavailable and physiologically active than the conventional form we all know about? Well, that form does exist, and it is called Benfotiamine. Benfotiamine has been gaining popularity lately, especially among people dealing with diabetes and other metabolic disorders. But what exactly is Benfotiamine, and what makes it different? Lets explore Benfotiamine, its bioavailability, and its physiological effects.
Thiamine, also known as Vitamin B1, is a nutrient that plays a crucial role in energy production, nerve function, and metabolism. It is a water-soluble vitamin, which means it dissolves in water and is not stored by the body. However, conventional forms of thiamine have a limited ability to cross cell membranes and are easily excreted out of the body, rendering it ineffective for some individuals. This is where Benfotiamine comes in; it is a modified form of Vitamin B1 that is fat-soluble, highly bioavailable, and because cells are wrapped in lipid fat this form of B1 is capable of crossing cell membranes with ease.
Since our cell membranes are composed of lipids, fat-soluble nutrients can easily penetrate the cell barrier and get into living cells where the vitamin is needed. Upon entering the bloodstream, benfotiamine is converted to thiamin pyrophosphate (TPP), the biologically active co-enzyme of thiamin, which is responsible for energy metabolism. By raising the blood levels of TPP, benfotiamine has been shown to support glucose metabolism, reduce oxidative stress and inflammation, and protect against the damage caused by high levels of advanced glycation end products (AGEs).
In addition to its bioavailability, benfotiamine has been shown to have several physiological effect on the body. One of the key enzymes that benfotiamine influences is transKETOlase, which is involved in the pentose phosphate pathway, a metabolic pathway that generates NADPH, a vital molecule that protects cells against oxidative stress. By stimulating transKETOlase, benfotiamine supports the diversion of excess glucose to the pentose phosphate pathway, thereby reducing the production of reactive oxygen species and increasing the production of NADPH.
Another significant benefit of benfotiamine is that it helps protect the nervous system. Chronic high blood glucose levels are known to cause oxidative stress and to damage the peripheral and central nervous systems. However, benfotiamine has been shown to help lower oxidative stress markers and reduce the risk of nerve damage. This can in turn help reduce pain, numbness, and tingling sensations associated with nerve damage, making it a promising adjunct therapy for people with diabetic neuropathy.
In Summary: benfotiamine is a modified and bioavailable form of thiamine that offers unique benefits compared to conventional forms of Vitamin B1. Its fat-solubility enables it to cross cell membranes, raise levels of thiamin pyrophosphate, stimulate the transKETOlase enzyme, and support proper glucose metabolism. Its notable effects on the nervous system make it an attractive therapeutic agent for people with diabetic neuropathy. If you're seeking an alternative and highly effective form of thiamine, benfotiamine is definitely worth considering. Give it a try today!
7-Keto-DHEA: The Metabolite That Can Help You Maintain a Healthy Weight
August 19, 2022 12:20 PM
As we age, our bodies produce less and less Dehydroepiandrosterone (DHEA) and its metabolite 7-KETO-DHEA. This can lead to a decrease in metabolic rate, making it more difficult to maintain a healthy weight. That's where 7-KETO® comes in. This unique ingredient has been shown to help with weight maintenance when combined with a healthy diet and exercise routine.* Want to learn more? Read on!
What is DHEA and what does it do?
DHEA is a hormone that is produced naturally in the body. It is responsible for a number of functions, including regulating metabolism and supporting the immune system. DHEA levels decline as we age, which can lead to a number of health problems. supplementing with DHEA has been shown to improve mood, increase strength and stamina, and promote healthy skin and bones. It can also help to boost the immune system and fight the effects of aging. If you are considering taking a DHEA supplement, it is important to speak with your healthcare provider first to ensure that it is right for you. 7-KETO DHEA is a metabolite of DHEA, but the great thing about 7-KETO, it does not convert to pro hormones like estrogen and testosterone, it stays as DHEA in the body.
How can 7-KETO® help with weight maintenance?
7-KETO-DHEA is a hormone that is produced in the body naturally. It helps to maintain lean body mass and promote thermogenesis, which is the production of heat in the body. 7-KETO also helps to boost metabolism and support a healthy weight. In addition, 7-KETO has been shown to provide some protection against age-related weight gain. Studies have shown that 7-KETO can help to reduce body fat and increase lean muscle mass in both men and women. Furthermore, 7-KETO has been shown to help improve glucose tolerance and insulin sensitivity. As a result, 7-KETO may be an effective tool for maintaining a healthy weight.
Who should take 7-KETO-DHEA supplements and how much should they take per day?
Generally, 25mg - 100mg per day is sufficient for men and women.
Benefits of MCT Oil On the Keto Diet
May 03, 2019 02:39 PM
MCT oil is a good companion to a keto diet because the medium chain fatty acids contained in the oil convert more easily to ketones than short- and long-chain triglycerides found in other types of fats. In addition, MCT oil has a thermogenic effect in the liver, which can positively support your metabolism. This is extremely beneficial if you are trying to lose weight. MCT oil can also provide an energy boost during exercise and it is easy to digest. Finally, MCT oil is great fuel for the brain, helping to clear brain fog and boost overall cognitive function.
"Increases energy — MCTs are are readily used for energy, less likely to be stored as fat, and can help keep you in a “fat burning” state. Some studies have also shown they can boost exercise endurance and performance."
Read more: https://draxe.com/mct-oil-on-keto-diet/
Can I Eat Fruit On a Keto Diet?
April 25, 2019 04:45 PM
The ketogenic diet is now trending across the globe, but many have many impressions about this eating regimen that are far from the truth. One of these myths surround the fact that keto dieters cannot consume any carbs at all, making the majority of fruits off limits. Keto followers can actually have up to 50 grams of carbohydrates to start, and they are encouraged to consume healthy fruits that are low in carbohydrates such as lemons or avocados.
"Higher carb fruits are going to be harder to incorporate into a keto diet while still allowing room for the liberal intake of vegetables and avocados encouraged in the Keto Reset."
Read more: https://www.marksdailyapple.com/fruit-keto/
9 Reasons You’re Not Losing Weight on Keto
April 22, 2019 04:13 PM
The keto diet can be a very effective way for individuals to shed excess pounds, but if it is not practiced correctly, the results will remain limited. In order to optimize the diet’s effectiveness, dieters who find their progress stalling should attempt to reduce the amount of carbohydrates and proteins they are eating, assess whether their overall food intake might be either too low or too high, focus on triggering ketosis, get regular sleep and exercise. If these strategies fail, it might be time to adjust inflated expectations or consider the possibility of a medical condition that is inhibiting weight loss.
"To calculate net carbs, simply subtract the total grams of fiber from the total grams of carbs in your foods. High-fiber keto foods like certain veggies are great choices to help keep carb consumption low while squeezing in plenty of vitamins and minerals to support better health."
Read more: https://draxe.com/reasons-not-losing-weight-on-keto/
The Best Keto Fiber Foods & Why You Need Them
April 18, 2019 01:43 PM
The Keto diet is well-known for emphasizing the value of healthy fats, but that doesn't mean it neglects the importance of fiber. It is not uncommon for those transitioning to the low-carb, high fat Keto diet to experience problems with digestion. The solution is to consume high fiber foods that keep you in a state of ketosis. These include non-starchy vegetables (e.g., cabbage and asparagus) as well as seeds and nuts. Keto fiber supplements - such as Gum arabic and Chia seeds - can also serve to maintain digestive regularity.
"Eighty percent of your total daily calories should be coming from foods like olive oil, coconut oil, grass-fed butter, nuts and seeds."
Read more: https://draxe.com/best-keto-fiber-foods/
How MCT oil supports brain health and improves memory
March 20, 2019 05:04 PM
MCT oils or Medium-Chain Triglycerides have numerous health benefits. For those with digestive issues, the good news is that they are easily absorbed and metabolized. The body can burn them for fuel as opposed to storing them as fat. They also cause levels of ketones to rise in your blood stream, making them great for weight loss, as a sort of short cut for the keto diet.They help in the development of neurotransmitters so they are great for memory issues. Some recent studies have shown improvement in brain function so they are being studies as a possible route for treatment of cognitive problems such as Alzheimer.
"MCTs have been shown to decrease fat and increase lean muscle mass, and MCT oil is currently sold to promote weight loss and improve athletic performance and endurance. MCTs are also routinely administered to prevent muscle wasting in critically ill patients."
Read more: https://www.naturalhealth365.com/mct-oil-brain-health-2816.html
Keto Diet and Diabetes: Do They Work Well Together?
February 26, 2019 03:36 PM
Some experts say the keto diet works well for people with Diabetes. The Keto diet involves getting your body to burn fat rather than sugar for energy. This involves eating a limited amount of carbohydrates. This works for people with Diabetes because it reduces the need for insulin and takes carbohydrates including sugar out of the diet. This is the most concerning aspect for a normal Diabetic. Multiple studies have shown benefits for people with Type 2 Diabetes and prediabetics.
"Let’s take a look at whether or not the keto diet may be a healthy choice for you and your diabetes management!"
Read more: https://draxe.com/keto-diet-and-diabetes/
Powerful organic compounds in cannabis can slash some cancers by 50%, researchers say!
January 19, 2019 10:52 AM
Terpenes is a compound found in citrus fruits, rosemary, frankincense, and cannabis. Because it includes many compounds including THC, ketones, esters, lactones, and THC not found together in the same rate in other plants, it is a better health treatment than anything created by the pharmacy companies. Terpenes also has limonene and pinene, which help with anti-inflammation in healing cancers, and reducing stress. Joy Smith shares a story of having cancer, trying chemotherapy and being given just weeks to live, but attributes cannabis oil to saving her.
"Medical marijuana is a booming industry, and the use value of cannabis just continues to expand as we learn more about this heavily prohibited, but clearly medicinal, plant."
Read more: https://www.naturalnews.com/2018-11-23-organic-compounds-in-medical-cannabis-slash-some-cancers.html
6 Reasons why boswellia is one of the most powerful herbal extracts available today
January 19, 2019 10:09 AM
The more common name for boswellia is frankincense, and it is known for having a plethora of health benefits. Frankincense is made from the gum resin that originates from the boswellia tree. This boswellia resin has the ability to promote several incredible health benefits such as helping fight against various cancers, as well as preventing them in the first place. This is due to the anti-inflammatory aspects of frankincense, and an acid called Acetyl-11-keto-?-boswellic acid that naturally has the ability to fight cancer.
"This herbal extract has a long history of being used as perfume, incense, and medicine due to is therapeutic and anti-inflammatory properties."
Read more: https://www.naturalnews.com/2019-01-15-6-reasons-why-boswellia-is-one-of-the-most-powerful-herbal-extracts-out-there.html
Omega-3 benefits for brain health are well documented; now researchers have determined they help prevent Alzheimer’s
December 19, 2017 03:59 PM
Omega-3s are beneficial for the brain and may help prevent Alzheimer's. Coconut Oil is shown to have this important nutrient. There's no need to go to your favorite drug store when you can get this from nature. Coconut oil has ketones which the liver treats as food. The liver converts the coconut oil into an alternative energy source for the body and brain. This has tremendous benefit for many aspects of the body's functions especially the brain function.
"Omega-3s are just one piece of a much greater anti-aging nutritional puzzle, particularly as it pertains to brain health."
Read more: https://www.naturalnews.com/2017-12-11-omega-3-benefits-for-brain-health-are-well-documented-now-researchers-have-determined-they-help-prevent-alzheimers.html
Keto Diet for Women: Benefits, Food List & Tips to Overcome Side Effects
June 06, 2017 09:14 AM
While existing somewhat below the radar, the ketogenic, or keto diet, has been around for almost a hundred years. In a nutshell, it requires the follower to get three fourths of their diet from healthy fat sources, a radical shift from the high carb diet prevalent today. Notable as a good way to shed pounds and avoid complications of aging, such as insulin resistance and neurological impairment, the diet’s statistical backup has so far centered mainly around rodents and male humans. Anecdotal evidence does suggest, however, that the diet is beneficial for women undergoing perimenopause and menopause. One practitioner, in particular, advocates combining a keto diet with an alkaline diet, to avoid some of the discomfort users have when undergoing the radical shift in intake. A more alkaline pH is good for the body. So, the combination is a win/win.
"Fasting is a key aspect of a healthy diet and has many anti-aging effects."
Read more: https://draxe.com/keto-diet-women/
Keto Diet Food List, Including the Best vs. Worst Keto Foods
May 14, 2017 03:44 PM
Dieting is the practice of eating food in a regulated and supervised fashion to decrease, maintain, or increase body weight. In other words, it is conscious control or restriction of the diet. Many forms of dieting have existed for years. None is as effective as the Keto Diet though. It helps stimulate weight loss easy, prevents diabetes, and reduces your HDL cholesterol by eating simple vegetables and proteins. Your menu variety is high and portions are important.
"Unlike many fad diets that come and go with very limited rates of long-term success, the ketogenic diet has been practiced for more than nine decades (since the 1920s) and is based upon a solid understanding of physiology and nutrition science."
Read more: https://draxe.com/keto-diet-food-list/
Wisconsin's war on butter is an attack on fundamental personal freedom
March 29, 2017 09:59 AM
Kerrygold butter got pull from all stores in Wisconsin not because of any safety issues, but simply because the state wants domestic products to have an advantage over foreign products. Kerrygold has grown in popularity since people have been shifting over to healthy fat diets such as paleo and keto. A popular drink that has emerged from this is known as Bulletproof, which requires grass-fed butter. People of Wisconsin are outraged that the state has banned this brand of butter and feel that it attacks their freedom as consumers.
Read more: Wisconsin's war on butter is an attack on fundamental personal freedom
What is a ketogenic diet?
February 25, 2017 05:59 AM
The KETOgenic diet is a very low-carb, high-fat diet that shares many similarities with the Atkins and low-carb diets. It involves drastically reducing carbohydrate intake, and replacing it with fat. The reduction in carbs puts your body into a metabolic state called KETOsis. When this happens, your body becomes incredibly efficient at burning fat for energy. It also turns fat into KETOnes in the liver, which can supply energy for the brain
The ketogenic diet: Why the HIGH FAT plan results in 'more effective weight loss'
February 09, 2017 07:59 AM
The KETOgenic diet is high in fat and low in carbohydrates. It is believed that it can aid weight loss. When blood sugar is low in supply, the body is forced to use KETOnes it produces from fat for energy. By eating a high fat diet, the body is forced to switch to burning KETOnes for energy thus burning fat more efficiently.
"According to Diet Doctor, the ‘KETO’ in a KETOgenic diet comes from the fact that it makes the body produce small fuel molecules called KETOnes."
Why the Blood-Brain Barrier Is So Critical (and How to Maintain It)
November 25, 2016 10:59 AM
It’s imperative to maintain a health blood-brain barrier. This serves as a guard for our brains letting in important things like glucose, amino acids, nutrients, and KETOnes while warding off toxins and pathogens. Ways to promote BBB health include taking vitamin B, drinking tea/coffee for caffeine, eating prebiotic fiber, upping magnesium intake, and sleep, just to name a few.
"The job of the gut lining is to be selectively permeable, allowing helpful things passage into the body and preventing harmful things from getting in."
Can Glutamine Improve Nitrogen Balance in the Body?
May 07, 2014 09:08 AM
Can Glutamine Improve Nitrogen Balance in the Body?
Essentials of glutamine have been found to be many. Nowadays there are commercially produced glutamine which are taken as strong anti-catabolic supplement.
Benefits of Boswellic Acid To The Body
April 20, 2014 08:25 PM
Benefits of boswellia
Rarely do people bank on herbs for treatment. Chemically manufacture medicines have taken over. However, what makes Boswellia herb very important? This herb has been used for a very long time. It is extracted from the Boswellia serrate tree. This herb is popular among other pharmacological medicines because of its medicinal values of reducing the effect of inflammation and inflammation related diseases.
What is inflammation?
Our body goes through very complex biological processes to keep us healthy. Inflammation is one of them. Inflammation has been the response action that the body takes towards an intruder. The body does this by producing prostaglandins and leukotriene; they are otherwise called inflammation mediators. Most of the time, the intruder can be harmful stimuli or pathogens and damaged cells. The body responds by causing acute pain in places like toes and fingers. Besides the pain, heat, swelling, redness and loss of function are signs of inflammation. Note that inflammation is not an infection.
Examples of inflammatory disease
Examples of inflammatory diseases are bronchial asthma that leads to narrowing of the respiratory tract and makes breathing difficult. Diabetes, type 1 is an inflammatory disease that is caused by the inflammatory mediators. They eat up the pancreas until it is exhausted. Production of insulin to counter diabetes will be affected largely.
How boswellia works
Boswellia releases boswellic acid. This is the main ingredient that is used to fight and heal inflammation. It does this by suppressing the release of prostaglandins and leukotriene. Bowellic acid comes in many forms. Acetyl-11-KETO-B is one example that when released, inhibits the synthesis of enzymes that will produce leukotriene hence lead to inflammation. Constant use of this herb heals and prevents the body from inflammation diseases.
Besides healing inflammation diseases, boswellia reduces the effects of brain cells tumor and colon cancer. The herb can be used to activate tumor suppression genes, a genes that will control and eventually reduce the growth of cancer cells.
D Limonene Solvent - What Is It and How Does It Work
April 11, 2014 10:01 AM
What is a D Limonene
D Limonene is the essential part of oil concentrated from citrus skin. It has two essential utilization: as nourishment evaluation D Limonene to add citrus flavor to non-citrus sustenances, and as specialized evaluation D Limonene to include citrus fragrance or citrus cleaning force to a mixture of cleaners. The production of the recent happens when pressed skin is set in a steam extractor, which gathers the ensuing steam and makes an oil layer that buoys on water.
As a consequence of the regular living development, D Limonene use in business items has expanded drastically, especially cleaning results, where it might be utilized as an unadulterated dissolvable or a concentrated dissolvable that could be weakened. D Limonene is important as a supplanting for customary solvents, a number of which transmit Hazardous Air Pollutants (Haps) or exhaust from Volatile Organic Compounds (Vocs). Solvents that are regularly traded with D Limonene dissolvable incorporate methyl ethyl KETOne, ch3)2co, toluene, glycol ethers, and various fluorinated and chlorinated solvents. In institutional settings, D Limonene dissolvable is commonly blended with a surfactant, preparing an answer holding 5-15 percent D Limonene.
From provincial cleaners found at retail chains to modern cleaners that oblige unique requesting, there is no deficiency of results holding D Limonene. Anyhow in the event that you require a modern adaptation of the dissolvable, discovering one that offers the same or better cleaning power as its dangerous partners might be troublesome. One case of a D Limonene dissolvable that helps is VORTEX citrus cleaner and overwhelming obligation degreaser, a natural semi-fluid dissolvable that serves as a parts cleaner and general mechanical cleaner. With a 100 percent natural plan, VORTEX is biodegradable however holds the ability to uproot oil, tar, oil, black-top, and natural saps in one stage. VORTEX's extra profits incorporate no risky materials or recorded solvents, no hurtful exhaust, and no petroleum distillates.
WHAT YOU DIDN'T KNOW ABOUT COCONUT OIL
February 06, 2014 07:56 AM
Introduction to coconut oil
Coconuts have come under close scrutiny by health experts and enthusiasts alike. The popular nut that is favored by the climates at the tropics is slowly cementing its place in household shelves worldwide. The white fleshy part has given us a healthy oil with a diverse resourcefulness.
Benefits of Coconut oil
Coconut oil's reputation had been blemished by inconclusive studies that had suggested that due to its 90 percent concentration of saturated fats, it couldn't pass for a healthy oil. High saturated fat content is usually associated with artery clogs and this, in the case of coconut couldn't be any further from the truth. Coconut oil is arguable the richest source of saturated fat. Contrary to popular belief, during digestion, the fatty acids in the oil are sent to the liver where they are converted to energy or into KETOne bodies that help counter brain disorders such as Alzheimer's.
Coconut oil has also wound its way to the breakfast table as a spread. It beats butter hands down as the healthy alternative when taken on toast.
It adds a remarkable nutty flavor to your food when used as a cooking fat. The fact that it does not exhibit any signs of rancidity under high temperatures as most cooking oils do, only underpins its reliability. Whether you use it to fry an egg or make a fuller meal, the health benefits it brings to the table are unparalleled.
Coconut oil has also crept into the snack world. Movie theatres have pioneered this trade by using it to prepare popcorn. Australian snack producers have also incorporated it into some of their beloved treats such as chocolate crackers. Bakers are opting for it as they also caught in this healthy food revolution.
We have also seen coconut oil used in massages, as an anti-dandruff and also as skin moisturizer.
The comprehensiveness of this oil makes it the ultimate everyday supplement to you as an individual and even your home.
Is Coconut Oil A Brain Food?
January 26, 2014 09:34 AM
It is amazing how coconut oil has been ascribed as a good brain food.
Since Dr. Mary Newport associated coconut oil with the ability to cure Alzheimer’s disease, it has attracted the attention of researchers and other interested parties. However, her attractive explanation of how the oil helped her husband to improve her husband’s Alzheimer’s disease can be described from the observation of an Alzheimer patient’s brain.
Taking into consideration Axona that is usually used by Alzheimer’s patients, its active ingredients is the caprylic acid that is extracted from the oil. As a substitute, Dr. Newport used coconut food products such as oil and milk in her husband diet to achieve the same quantity of MCTs. This improved her husband’s condition a clear indication that coconut oil has some medicinal value. From a scientific point of view, it is approved that the disease is caused by insulin resistant cells thus causing the brain to unsuccessfully use glucose to fuel their activity. In its place, KETOne bodies are used as a substitute fuel supply. Coconut oil is a good supply of medium-chain triglycerides (MCTs), for instance caprylic acid that is simply transformed into KETOne bodies in the liver when ingested. Then they act as an alternative of glucose which provides fuel for the brain. Neuroprotective effect of the coconut oil is attributed to the KETOne bodies formed as a byproduct of coconut oil metabolism. Therefore, leading to an energy metabolism. The KETOne bodies will then supply the compromised brain structure with the much-needed alternative fuel source from the KETOne bodies.
However, it is of the essence to state that coconut oil is only known for improving the condition. For this reason, there has been an increased call for more research, particularly human clinical trials. Since there is no any cure yet, coconut oil is going to remain a good brain food of choice for others who are experiencing Alzheimer.
Facts about Astaxanthin
October 22, 2013 10:47 PM
Astaxanthin is said to be a carotenoid which belongs to larger class of phytochemicals which is known as terpenes. It is built up of five carbon precursors. It is a metabolite of canthaxanthin and zeazanthin which contains both KETOne and hydroxyl fuctional groups. Astaxanthin is a lipid-soluble pigment and is colorful. The color of it is due to the extended chain of conjugated double bonds which is also responsible for the astaxanthin’s antioxidant function. It is found in feathers of some birds, yeast, trout, shrimp, crustaceans, crayfish, krill, salmon and micro algae. The red color of cooked shellfish and red color of salmon is due to the presence of astaxanthin.
How Astaxanthin Helps the Eyes?
When astaxanthin is combined with omega-3 fatty acids and Vitamin E then it helps the eyes to recover the watery condition and it lubricates it too. It helps the eyes to absorb Vitamin E by which it then nurtures and feeds the choroid and optical nerve which is behind the retina. This is the place where the blood vessel enters in to and leaves and this is the place where communication between retina and brain are established. The macula is protected by astaxanthin by its antioxidant activity and it also helps in eliminating the free radicals. It helps in reducing the risk of cataracts and AMD. It also helps in preventing the eyestrain and it also decreases its effects. The inflammation in the muscles of the eyes is decreased by it and it also improves the blood flow of the eyes.
Health Benefits of Astaxanthin
It is considered as a strongest natural antioxidant which crosses the brain-blood barrier and protects the nervous system and brain, works in every part of skin, organs and body, crosses the retinal-blood barrier and thus protect the eyes and it reaches inside and out of every part of the cell. It also helps in repairing the injured tissue.
Coconut Oil for Memory Enhancement
December 27, 2012 12:53 PM
Coconut oil has been widely used for centuries for various purposes. Mainly, it is a cooking ingredient, used for frying and for adding flavor to meals. Aside from this, many nations have different ways of using it as treatment for various illnesses. Countries like Jamaica, Panama, and India believe that ingesting the oil helps prevent contracting any disease and helps in the speedy recovery when sick.
People from the Philippines and Thailand use the oil for massaging to provide relief from painful muscles and joints. Other topical uses are for moisturizing of the skin and for the healthy growth of hair.
Since 2008, new studies have been conducted to test the effects of coconut oil in enhancing the memory and to cure Alzheimer's disease.
MCT (Medium Chain Triglycerides) Benefit:
The most astounding find is the presence of MCT or medium chain triglycerides in coconut oil in high concentration. This MCT creates a string of processes that ultimately helps in curing neurodegenerative diseases.
MCT against Amyloid-Beta
Amyloid-beta is a protein that forms into plaques in the brains. They decrease the efficient functioning of the nerve cells that then causes the decline in memory.
Most drugs prescribed to Alzheimer patients target these plaques, to dissolve them and consequently see an improvement. Studies done on dogs by incorporating MCT in their diets showed that the levels of amyloid-beta has declined, which is a very positive effect. Likewise, energy levels in the brain have gone up among the test subjects.
MCT to Promote KETOne
One cause of Alzheimer's disease is the inability of the brain to metabolize glucose and transform it to energy. As you all know, glucose is the main energy source of the body that provides it the energy it needs to function. This glucose comes from the carbohydrate that comes from food sources. Without this fuel, the brain cells could degenerate. Fortunately, glucose is not the only source of energy for the brain. It can also come from KETOnes, which are produced from fats in the liver.
However, the liver does not continually produce this. The human body, being smart as it is, only produces KETOnes when the glucose level drops in order to compensate for the loss of energy source. This is why people who have cognitive disorders often go on a fat and protein diet to trigger the production of KETOnes, by lowering their intake of carbohydrates. Still, maintaining such a diet for long periods is hard. The good thing is studies have shown that ingesting MCT has increased the level of KETOnes in the body, regardless of the amount of glucose present in the system. It is believed that MCT is converted to KETOne, thus, providing the brain the energy it needs.
MCT and Omega-3 Fatty Acids
Another study done on dogs showed an increased level of omega-3 fatty acids in their brain. Omega-3 fatty acids have many benefits to the body, including improvement of brain function. They support the effective transmission of energy from one neuron to another through the synapses. This consequently makes learning easier, promotes faster reactions, and heightens memory.
Unfortunately, this fatty acid is not produced in the body and people have to rely on food sources, such as fish and nuts. Studies have shown that MCT from coconut oil induces the production of omega-3 from fats that are already present in the body.
Raspberry ketone for weight loss
June 11, 2012 08:21 AM
Raspberry KETOnes are natural compounds that are found in raspberry plants and that are able to regulate metabolism in the same manner as synephrine and capsaicin since they are chemically similar. KETOnes are also responsible for the pleasant smell of raspberries and they are also used as a flavoring ingredient for processed food. Various studies have shown that these KETOnes are also extremely potent fat burners and this is the main reason why they are highly marketed as being an effective solution for weight loss.
It was scientifically proven that people who choose to live a healthy lifestyle and who also watch their weight can have a significant benefit from using raspberry KETOne supplements. Most people can lose a considerable amount of weight by using these supplements and it works with any type of diet. It also works extremely well and burns fat even more effective when it is combined with a high protein diet that is low on fat. This is basically one of the main reasons why this supplement is so high in demand nowadays.
Whenever raspberry KETOne is used as a supplement the core temperature of the body is significantly raised. Therefore the metabolism rate will also be increased and it will cause the body to burn fat and calories much faster, making this compound very popular and effective when it comes to weight loss. In addition, these KETOnes will also make the overall fat that the body is absorbing from a regular diet to be reduced. In fact, a study conducted on rats in Japan reveals that this compound is extremely effective in fat loss after it prevented fat from accumulating in their tissues. This is a strong evidence that proves how effective for boosting metabolism and burning fat this supplement really is. Although no study was documented on humans, there are various positive feedbacks from users that prove to be effective and free of any side effects as well.
Due to the raspberry KETOne effectiveness, most nutritionists and dietitians are also recommending to eat a few raspberries along with meals. People who went for a healthy diet and also consumed raspberries on a regular basis have experienced positive weight loss results. This fruit is also very delicious and is rich in fiber so it is a good addition to any meal. Raspberry KETOnes are also known for several other health benefits such as maintain the level of fat and cholesterol in the body. Also, by consuming this compound you can also maintain your blood pressure levels in normal range, therefore these KETOnes are also good for maintaining the overall health for the cardiovascular system.
So basically all these healthy and beneficial properties make raspberries a very healthy fruit. They also contain anti-oxidants which are most needed for combating the harmful free-radicals present in the body. Since it would take many pounds of actual raspberries in order to get any significant results, supplements based on this compound are the perfect choice in order to get the recommended dosage (usually around 100-300mg).
Why Choosing 7-Keto DHEA Over Standard DHEA
February 25, 2012 06:36 AM
The Importance OF DHEA Nowadays
DHEA (Dehydroepiandrosterone) is probably one of the most abundant hormone that can be found in the human blood. Being produced in the adrenal cortex, this important steroid it's very important in reducing body fat, cholesterol and also the alleviate angina. In addition to all that, DHEA has been widely used to treat coronary artery disease, Alzheimer's, sclerosis, depression, osteoporosis and even cancer. Because of this, DHEA is known under the name of “Fountain of youth.”
DHEA levels will usually decrease with age. This decrease might lead to high cholesterol levels, cardiovascular disease, neurodegeneration and even obesity in many cases. These are only a few reasons that make of DHEA an imperative hormone for our body.
What Makes 7-KETO DHEA Better Than Standard DHEA?
7-KETO Dhea it's similar to its cousin hormone, however it is much better for your body. Some of its extra benefits that can't be find in the standard DHEA are:
- Enhances your immune system.
- Improves your memory.
- Increases your muscular mass and strength.
- Help you lose fat naturally.
- Increases the activity of your thyroid gland.
- Reduces the signs of aging.
Overall, 7-KETO DHEA is a safer and a more potent derivates of standard DHEA, proved to be safer and with less side effects. 7-KETO DHEA is a real breakthrough as it represents the next generation of DHEA supplements. How was this discovered?
In the previous years, the University of Wisconsin conducted an extensive research in order to discover the best DHEA derivates. Over more than 150 DHEA derivates analyzed, a single compound stood out- it was 7-KETO DHEA. This compound provided greater benefits over a long-term period than the standard DHEA. Nowadays it is considered an improved and much safer form of this important hormone, called DHEA.
In addition to providing all therapeutic benefits of DHEA, this improved hormone won't be converted into some unwanted sex steroids. It also lacks any other hormone- elevation that was commonly found in the standard DHEA supplements. This product makes you feel young again without endangering your body tissues or internal organs, compared to the traditional DHEA whose side effects were found destructive to some of your body tissues.
Why To Take This Hormone?
7-KETO Dhea was proven to be a safe product in a clinical trial, being tested on many people and animals. The only side effects this hormone might have are some mild heart palpitations and sometimes acne. Still, these side effects won't usually appear on people who take this product as prescribed and also avoid taking an overdose.
The benefits this hormone provides to our body are very real, as they were discovered at those who took this hormone for a longer period of time. Enhancing your immune system, the response to viruses is stronger. You will feel healthier and better protected.
When Should You Take It?
This hormone is to be taken only after you reached 30 years old, as you won't need it before that age. DHEA hormone begins to decrease considerably only after you reach 30, so this process will continue until you reach 70 or 80 years old. Taking the 7-KETO Dhea hormone will help you feel and be younger.
Raspberry Ketones can help you in losing Weight
February 07, 2012 02:14 PM
According to NHANES (National Health and Nutrition Examination Survey), more than two thirds of Americans are overweight and about one third are obese. Obesity is definitely a serious medical condition that not only reduces your stamina, but can also lead to various health complications such as hypertension, heart disease, diabetes, cancer, sleep apnea, menstrual irregularities, atherosclerosis and many more.
Any attempt to lose weight can succeed only when it is multidimensional. In order to get the desirable results, you will have to bundle various weight loss techniques to get the desired results. In some instances, this can also lead to deleterious side effects. For example, stringent dietary restrictions may result in various nutritional disorders such as goiter, osteoporosis, scurvy and so on. Excessive exercises can also cause various maladies such as depression, fatigue, muscular injuries and insomnia. So What Are Raspberry KETOnes?
Raspberry, which is an edible fruit, is quite rich in Vitamin B, antioxidants, folic acid, riboflavin, niacin, magnesium potassium copper and manganese. Aside from these, it also has large amounts of KETOnes, referred to as “Raspberry KETOnes”. Actually, KETOnes are phenolic compounds that help you in losing excess body weight without harming your body in any way.
How do Raspberry KETOnes work?
Raspberry KETOnes, being natural substances work in an entirely different way. Unlike various other weight loss therapies, they work all alone and in the most effective way. They persuade the body to release norepinephrine, which is a stress hormone and affects that part of your brain, which controls responses and attention.
Along with norepinephrine, raspberry KETOnes trigger a increase in the heart rate, which increases the supply of oxygen to the brain. This also increases the blood flow to skeletal muscles. This results in increase in the energy requirements of the body. In order to get the desired energy, the stored body fat is broken down into much simpler products. Therefore, this lipolytic act of norepinephrine results in body losing considerable fat in an easy and healthy way.
Raspberry KETOnes have a molecular structure which is identical to the synephrine (orange peeols) and capsaicin (chili peppers). Both of these compounds active a enzyime known as lipase which triggers rapid metabolism of body fats. Raspberry KETOnes ensure that the lipolysis process continues at a constant rate. This results in enhanced weight loss within a short time period.
Raspberry KETOnes also increase the production of T and B cells and thus play an important role in strengthening the immune system of the body. Aside from that, they also nourish the body with all essential micronutrients such as vitamin C, vitamin B, copper, magnesium, manganese and copper.
If you are interested in using raspberry KETOnes for losing excess weight, then you will find many exciting options on the market. Before buying a supplement or pills, you must ensure that it is made by a reputable manufacturer and comes at a reasonable price and has safe ingredients. Many sellers on the Internet offer exciting deals and you can easily order your requirements right from the comforts of your home.
Why Is The Amino Acid Tyrosine So Good for the Brain?
June 18, 2011 12:20 PM
Tyrosine is an amino acid that serves as an immediate precursor to several organic compounds found in the brain and the central nervous system. It is one of the 20 amino acids utilized by cells in protein synthesis. As such, it is an important component of the human diet, albeit not classified as an essential nutrient. Mental infirmities not related to age has been linked to tyrosine deficiency.
There is no daily value for tyrosine, but it is an integral part of proteins obtained from both animals and plants. Also, supplementation of tyrosine has not shown any adverse effects. That being said, deficiency in tyrosine is not unheard of. In fact, there is a rare autosomal recessive disorder called phenylKETOnuria that interferes with the synthesis of tyrosine and leads to brain damage and seizures.
Prevents Brain Damage
Tyrosine is one of the amino acids necessary for the manufacture of neurotransmitters and proteins that display vital functions in the nervous system. In phenylKETOnuria, the synthesis of tyrosine from phenylalanine is impaired, causing the build-up of the latter. High concentrations of phenylalanine deprive the brain of other amino acids, such as tyrosine. This results in progressive mental retardation.
The presence of tyrosine in the central nervous system is very important in mental development. It works as nutrient for nerve cells that powers neuronal activities. Not surprisingly, regular intake of tyrosine has been observed to display cerebroprotective properties. It has also been linked to the prevention of headaches following an intense physical activity.
Improves Stress Tolerance
It has long been suggested that supplementation of tyrosine may improve stress tolerance, but studies that support this claim have surfaced only recently. High levels of tyrosine in the brain appear to improve physiological responses to stress in both animal and human studies. Many researchers believe that depleting levels of tyrosine in times of stress contribute to mental fatigue.
Tyrosine is a precursor to catecholamines, organic compounds that function as neurotransmitters and hormones. It is converted to epinephrine, or adrenaline, which is responsible for the activities in the peripheral nervous system during stress. It is also converted to norepinephrine, which sends signals to both sides of the brain and forms a neurotransmitter system within the brain and the spinal cord.
Promotes Mental Clarity
Tyrosine plays a role in sustaining mental clarity, the reason why it is thought to produce nootropic effects. For one, the availability of tyrosine in the brain improves mental function, especially under psychological stress. It is utilized by the brain in the manufacture of brain chemicals involved in cognitive function and even motor skills.
More importantly, tyrosine provides a ready pool of levodopa, which increases dopamine levels. Both tyrosine and dopamine levels have been observed to be low in individuals suffering from clinical depression, suggesting that tyrosine may provide mood-altering effects. Since there is no harm in regular intake of tyrosine, it has been promoted as an alternative to other mood enhancers.
May 08, 2009 10:00 AM
L-Cysteine is what is known as a non-essential amino acid, meaning that it can be biosynthesized by the body and hence not an essential part of your diet. Due to its possessing a thiol side chain, it is termed a hydrophilic amino acid with an affinity for aqueous systems. Because of this it is relatively highly reactive, and is therefore an important component of a large number of enzymes and proteins.
Although, after all, it is not an essential amino acid, deficiencies can occur in the young and in the old, and also in those suffering certain metabolic diseases. Dietary sources include high-protein foods such as chicken, turkey, pork, dairy products and vegetables such as cereals, broccoli, garlic and onions.
The biochemistry of this amino acid begins with another amino acid known as serine, and also methionine. The latter is fist converted to homocysteine, which is then combined with serine to form cystathionine. This is then converted into cysteine and alpha- KETObutyrate. The thiol group is highly reactive and gives cysteine its biological properties.
L-Cysteine possesses strong antioxidant properties due to the thiol group which easily undergoes redox reactions. However, it is for its detoxification effect on the body that the amino acid is mainly taken as a supplement. It is, therefore, these properties that we shall discuss first.
Cysteine can reduce the toxic effects of alcohol, such as a hangover or the more serious liver damage. The by-product of alcohol metabolism that does most damage and is responsible for the majority of the negative after-effects of excessive alcohol consumption is acetaldehyde. L-Cysteine converts acetaldehyde into the more acceptable acetic acid, and so prevents the aldehyde from having too much of a negative effect on your health and well-being. However, the results obtained from such studies have been from animals only, and the therapeutic effects of cysteine have not yet been tested on humans.
What has been tested and is known is that L-cysteine is effective in the detoxification of heavy metals in the body. A common source of heavy metal toxicity is mercury from amalgam fillings in the teeth. Although the Environmental Protection Agency (EPA) declared in 1989 that dental amalgams are a hazardous substance under the Superfund law, many people still have them in their mouths.
The thiol group and L-cysteine has a high affinity for mercury and other heavy metals, as previously stated, and a supplement can be used to remove from the body any mercury leached from mercury-based tooth fillings. It can also be used to bind to copper, lead and cadmium. Lead and cadmium are particularly toxic to the human body, and even though lead is no longer used in plumbing or paints, and cadmium in toys or paints, there are still many sources of these two heavy metals available that can lead to human toxification.
An L-cysteine supplement can be used to remove these heavy metals from the body. Any proteins containing cysteine will tightly bind heavy metals such as lead, cadmium, molybdenum, cobalt and mercury, and allow them to be excreted by the body in the usual fashion. This direct involvement in heavy metal detoxification is a very useful property of this amino acid.
Another detoxification application of L-cysteine is in direct involvement in protecting cellular glutathione levels, and also the prevention of the death of liver cells by acetaminophen poisoning. The latter is of particular interest to many people since acetaminophen is better known as paracetamol, and since this is a freely available over-the-counter drug, overdoses are not unknown. The result of an overdose is the necrosis of liver cells, with eventual liver failure and death.
The treatment of choice is N-acetylcysteine. If used within 10 hours of the overdose it is extremely effective, and even from 16 to 24 hours it is better than other controls. It is believed that the acetylcysteine liberates cysteine which, when available to the liver, enables the biosynthesis of glutathione. Glutathione can then maintain the production of the fifth metabolite required for the specific detoxification of the paracetamol/acetaminophen.
L-Cysteine is also an essential component in the biosynthesis of coenzyme A, an enzyme essential for the production of energy from fats and carbohydrates. It is also a very important component of hair, from which it is commercially produced. Without an adequate intake of L-cysteine the growth of healthy hair would not be possible.
There are several supplemental uses of L-cysteine including the treatment of bronchial conditions for which the amino acid can help to liquefy and clear mucus from the airways and lungs. It is also used to protect against side effects of chemotherapy treatment of cancers and for medical treatments for excessive exposure to radiation.
However, there are certain situations in which L-cysteine should be avoided when at all possible. Diabetics should not use it, and neither should those suffering from cystinuria, whereby large quantities of amino acids, including cystine, are excreted in their urine. L-cystine, incidentally, is formed by oxidation of L-cysteine.
Paradoxically the amino acid is one of the several hundred additives made to tobacco by the cigarette companies. Although, as with the majority of tobacco additives, its purpose is unknown there are two possible reasons for its inclusion. L-Cysteine is a known expectorant, so it could be added to promote the expectoration of mucus in the lungs which is promoted by smoking, and it also increases the production off the antioxidant glutathione that is depleted in smokers.
There are several other non-medical uses for the amino acid, but it is for is its detoxification properties that it is most used as a supplement. However, because it is largely derived from human hair or duck feathers, it may not be classed as kosher or halal in spite of many claims made to that effect, though the more expensive source of microbial fermentation from corn sugar can be.
The substance is recognized as safe by the FDA, and must be labeled as L-cysteine when it is present in a preparation intended for its therapeutic effects. Keep in mind however, that it should be avoided by diabetics.
Vitamins and Herbs
April 03, 2009 02:52 PM
The whole human body is made up of cells that contain their own genetic material. In a healthy body, these cells divide at a controlled rate, growing and repairing damaged tissues and replacing dying cells. This predetermined rate of cell division is what keeps our bodies healthy. If cells keep multiplying when new ones are not necessary, a mass of tissue, often known as a tumor, is formed. This tumor can be either benign or malignant.
Benign tumors are not cancerous and can occur anywhere in the body. Benign tumors do not cause a threat to health, do not metastasize, and do not grow back if removed. Malignant tumors are cancerous and are usually serious. Often times, they can be life-threatening. Malignant tumors grow uncontrollably, interfere with normal metabolic and organ functioning, and have the ability to metastasize and invade other tissues. If a portion of a cell’s DNA is damaged, the cell can become abnormal. When an abnormal cell divides, it forms new cells that are a photocopy of the damaged genetic material. This ongoing process occurs constantly within our bodies. The majority of the time our bodies have the ability to destroy these abnormal cells and maintain a sort of cellular equilibrium. If a crucial part of the DNA is destroyed and the abnormal cells cannot be controlled any longer, cancer forms. All cancer cells have two things in common: growing uncontrollably and having the ability to metastasize. The immune system does not recognize cancer cells as dangerous or foreign.
Although the exact cause for the cell damage that initiates the cancer process is unknown (theoretically free radical damage causes DNA damage), the chain of events that leads to cancer is very complex, and each individual body reacts differently. It is a combination of genetic, behavioral, environmental, and lifestyle factors that are thought to be involved in turning normal cells into abnormal cells, and abnormal cells into cancer.
There are also factors that are believed to slow the process, while other factors can speed up the process. Possible contributors to the development and growth of cancer can be divided into three categories: external, internal, and lifestyle. External factors include unhealthy workplace environments and exposure to air and water pollution, chemicals, pesticides, and herbicides. Included in the internal factors include both genetics and infections. Lifestyle factors are those we personally can most readily control, such as diet, smoking, drinking, and sun exposure. External and lifestyle factors account for 80 percent of cancer deaths in the United States.
Just as each of us looks different, each of our bodies has its own unique composition. Some of us may react adversely to what some of us react well to. This is why some treatments prove to be successful for some, but not for others. This is why dietary wellness and prevention is so important. If we can keep our bodies healthy and avoid known cancer-causing agents, we have a good defense against cancer in the first place.
The following nutrients and supplements are designed for persons who have been diagnosed with cancer, as well as for those who wish to enhance their chances of avoiding the disease: coenzyme Q10, colostrum, DMG, garlic, IP6, melatonin, MSM, proteolytic enzymes, selenium, 7-KETO DHEA, shark cartilage, SOD, vitamin A, shiitake extract, acidophilus, chromium picolinate, flaxseed oil, grape seed extract, kelp, l-carnitine, multienzyme complex, a multi-mineral complex, multivitamin complex, NAC, raw glandular complex, taurine, and vitamin B complex. Additionally, the following herbs may be beneficial: astragalus, birch, burdock root, cat’s claw, chaparral, chuchuhuasi, cranberry, dandelion, Echinacea, fennel, green tea, licorice root, macela, milk thistle, parsley, pau d’arco, red clover, suma, cardamom, cayenne, ginger, rosemary, sage, thyme, turmeric, ragwort, wood sage, curcumin, essiac, noni, olive leaf extract, rosemary, and boswellia.
All of the above listed herbs and vitamins can help restore the body to good nutrition and help boost the immune system so the body can find and fight back against cancer. Natural vitamins and herbs are available at your local or internet health food store. When purchasing supplements, look for name brand vitamins like Solaray and Source Naturals to ensure you receive quality and you get what you pay for.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
April 01, 2009 05:35 PM
Infertility is typically defined as a failure to conceive after a year or more of regular intimate activity during the time of ovulation. This term can also refer to the inability to carry a pregnancy to term. About 6.1 million American couples are impaired when it comes to their ability to have children, with 2.1 million of these couples being infertile. The exact cause of the problem can be extremely difficult to pinpoint, as ovulation, fertilization, and the passage to the fertilized ovum through the fallopian tube and to the uterus are extremely complex processes. In order for pregnancy to occur, many events must work together perfectly.
In 40 percent of infertile couples, problems that affect the male partner are either partially or wholly the cause of infertility. Infertility in men is usually the result of a low sperm count or an anatomical abnormality. There are a variety of factors that can result in a low sperm count. Among these factors are alcohol consumption, endocrine disorders, exposure to toxins, radiation or excessive heat, recent acute illness or prolonged fever, testicular injury, and rarely, mumps-induced wasting of the testicles. An abnormal enlargement of veins that drain the testicles, referred to as varicoceles, can cause infertility in men. This is because the veins of the testes are no longer able to moderate the temperature of the testicles correctly, which can negatively affect sperm.
The most common causes of infertility in women include an ovulatory failure or defect, blocked fallopian tubes, endometriosis, and uterine fibroids. Additionally, some women are able to develop antibodies to their partners’ sperm, which causes the woman to almost be allergic to them. Chlamydia, a transmitted disease which affects 4 million Americans each year, also causes many cases of infertility. There are also psychological issues, such as stress or fear of parenthood, which can also contribute to infertility.
However, in most cases, stress is usually the result of infertility, not the cause of it. Sperm abnormalities account for about 41 percent of infertility cases. The following reasons are the most common to explain why couples cannot conceive: the woman has endometriosis; the man has abnormal sperm, a low sperm count, or erectile dysfunction; the woman’s fallopian tubes are blocked; ovulation takes place rarely or irregularly; the couple is unable to have complete intimate relations; the cervical mucous attacks and kills the sperm; the woman does not manufacture enough progesterone to carry a baby to term; the woman is over thirty-four; and/or one or both members of the couple eats a poor diet and experiences too much stress. The following nutrients are extremely beneficial in helping one or both partners deal with infertility: selenium, vitamin C with bioflavonoids, vitamin E, zinc, DMG, octacosanol, phosphatidyl choline, essential fatty acids, l-arginine, manganese, proteolytic enzymes, pycnogenol, raw orchic glandular, raw ovarian glandular, 7-KETO DHEA, vitamin A, and vitamin B complex. Also, the following herbs have been shown to be beneficial in dealing with infertility: astragalus, damiana, ginseng, sarsaparilla, saw palmetto, yohimbe, dong quai, false unicorn root, gotu kola, licorice root, wild yam root, green oat, and yin-yang-huo. It should also be noted that heavy use of Echinacea, ginkgo biloba, and St. John’s wort may cause infertility in men, and should be avoided.
Infertility can be a complicated and mentally depressing due to lack of pregnancy by both men and women. Depression can lead to more stress and needs managed by a health care provider. Always consult your doctor when you think you are infertile. Natural vitamins like the ones listed above are available at your local or internet health food store. Look for name brands vitamins to ensure you receive quality supplements.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
L-Alanine Non Essential Amino Acid
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry.
Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein.
10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms.
L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine.
The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy.
The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-KETOglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose).
The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea.
In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction.
L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition.
A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high.
Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps.
Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure.
Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
August 26, 2008 04:58 PM
GABA is gama amino butyric acid, and is an inhibitory neurotransmitter that is essential for the proper function of your brain and the central nervous system, and has the effect of reducing excessive brain activity and promoting a state of calm.
For many people, the rush of daily life, with its problems, worries and external stimuli, can over-stimulate the brain to the extent that it can all seem too much for them. They feel anxious and overwhelmed, and wish that they could just go into a quiet corner to get away from it all. Most people have felt like that at some time, but the demands of life do not allow them that luxury. They just have to bear it and get on with life.
That is where GABA can come in. It can be used to bring your nervous system back to base, and make you feel more relaxed, calmer and more able to meet these challenges that life often throws at you. When you feel that you just can’t relax or concentrate on what you are doing, GABA can help you. If you look around you and everybody else seems OK, without apparently feeling the stress and irritability that you feel, and then perhaps your problem is due to a GABA deficiency. GABA is the principal inhibitory neurotransmitter in your brain, and a deficiency would certainly give you the symptoms that you are feeling. Let me explain why.
As your brain becomes excited, it can run out of control and needs some form of modification or inhibition to keep it acting as normal. Without this you would become increasingly more restless and irritable, and ultimately have seizures. GABA is not only the main inhibitor in your brain, but also helps in the production of endorphins that provide you with a sense of well being. That sense of calm you feel when endorphins are produced, for example during exercise or sexual intercourse, is commonly referred to as the ‘endorphin effect’.
GABA is at its highest concentration in specific areas of the brain, including the hypothalamus, the hippocampus and the central brain area, and is present in up to 40% of all synapses, the small gaps between neurons across which brain cells can communicate with each other.
It is produced during the Krebs or Citric Acid Cycle that is responsible for cell respiration or the production of energy from carbohydrates. It is synthesized from alpha-KETO glutarate, which is produced just before the Succinyl Co-A stage of the Krebs Cycle in the brain. Vitamin B6 in involved in its metabolism, and a Vitamin B6 deficiency can lead to a deficiency in GABA that might result in seizures.
Basically GABA works by inhibiting the firing of neurons in your brain, and thus reducing general brain activity. The GABA receptor allows more chloride ion to enter the brain cell, thus helping to maintain the electrical charge within the cells. Bezodiazepines (e.g. diazepam) work by increasing the effectiveness of GABA in opening the chloride ion cells to allow more chloride ion to enter the neurons, and caffeine does the opposite, and inhibits this property of GABA. Thus diazepam works as a minor tranquilizer and caffeine as a stimulant.
Alcohol has a similar effect to the benzodiazepines, increasing the release of chloride into the neurons, and is the major way in which alcohol affects the brain. In fact, tolerance to drugs and withdrawal symptoms can be explained by the receptors adapting to the drug. They may increase in number, which means that more of the drug is needed to work on them, and they can become hypoactive in the event of the drug being withdrawn, that enhances the symptoms that the drug was intended to treat.
So basically, that is the way that GABA works. In simple terms it increases the flow of chloride electrolyte to the brain, and in so doing affects our mood. This effect is enhanced by prescription drugs such as Valium and Ativan, which are used by those that suffer the effects of a GABA deficiency. However, these drugs have side effects, not the least of which is dependency due to the GABA receptors becoming modified to suit the drug. There is a more natural way to overcome many stress problems and symptoms of mood swings.
Knowing what causes these symptoms, it makes sense to eat foods that stimulate the creation of neurotransmitters to replace those that are deficient. Since GABA is produced in the Krebs Cycle and complex carbohydrates produce glutamine that is an important part of that Cycle, and is also the precursor to GABA, then the consumption of such foods should in theory produce more GABA. In this case the theory works, and you should eat foods rich in complex carbohydrates such as whole grains, brown rice and oats as part of your diet.
Other foods that are high in glutamine or its precursors, glutamic acid and glutamate, include citrus fruits, beef liver, broccoli, halibut and lentils. A useful supplement to take is L-theanine, an amino acid found in green tea, and available in supplement form. L-theanine can calm your nerves while maintaining clarity of thought. In other words it calms you down, but doesn’t make you drowsy and allows you to enjoy your day with anxiety.
Your doctor can determine whether or not you have a neurotransmitter deficiency through a simple urine test, and might also test your saliva for hormone content. A GABA supplement might be indicated, and if so it other beneficial effects on your body other than its effect on your brain cells.
It improves your sleep cycles and promotes vivid dreaming, and can also have a positive effect on your blood pressure. It is also an effective pain killer, and can provide relief from such conditions as back pain and arthritis. Its stimulating effect on the anterior pituitary gland to secrete Human Growth Hormone might also be regarded as a benefit by many. Increasing the level of HGH in your blood can lead to fat loss and improved anabolic activity (increase in muscle tissue). This can be of benefit to older people whose level of HGH secretion has dropped off, and who find it more difficult to lose fat.
GABA is a substance that has many known benefits and no known side effects other than a slight tingling and increase in heart rate when the supplement is first used. It has a definite benefit for people to whom the world seems too hectic and overwhelming.
June 13, 2008 12:18 PM
DL-Phenylalanine has been found to work in conjunction with the body’s natural ability to relieve pain. It helps to lengthen the lifespan of the chemicals in the brain that ease pain. It is especially effective in relieving pain from arthritis and aching muscles.
Some chronic pain can be treated with DL-phenylalanine through the stimulation of nerve pathways in the brain that control pain. Enhanced pain relief has been discovered when D-phenylalanine is used in conjunction with prescribed pain killers. This manufactured form of phenylalanine is used to block an enzyme in the nervous system that increases pain signals. The interruption of pain signals allows the healing mechanisms of the body to begin working faster.
DL-Phenylalanine is a chemical combination of half L-phenylalanine and half D-phenylalanine. L-Phenylalanine is the natural form of phenylalanine found in proteins all over the body. It is found in foods like beef, poultry, pork, fish, eggs, milk, yogurt, cheese, nuts, seeds and certain soy products. D-Phenylalanine is a synthesized form of the chemical, which means it is produced in a laboratory.
Phenylalanine as an Amino Acid:
Amino acids perform various major functions in the body. They assist in fulfilling the body’s basic needs from minerals and vitamins. They can act as neurotransmitters, which carry signals to and from the brain. They also aid in other parts of the body for communication between nerve cells.
Phenylalanine is one of the essential amino acids found in protein. This means it is required for human health, but cannot be manufactured by the human body. Therefore it has to be supplied through food consumption. It can also be found and taken in the form of powder, capsule, tablet or a topical cream. In the body, phenylalanine is converted into tyrosine, which is another amino acid needed to make protein. It is also needed to make certain brain chemicals and thyroid hormones. Phenylalanine deficiency signs include:
A rare disorder called phenylKETOnuria (PKU) happens in humans who are missing the enzyme required to metabolize phenylalanine. Symptoms of this disorder tend to appear between the ages of 3-6 months. These include:
If PKU is not treated within the first three weeks of life, it can cause severe and irreversible mental retardation. Women who are pregnant or nursing should avoid taking phenylalanine as a supplement in any form. DL-Phenylalanine may cause hyperactivity, jitteriness and anxiety in children.
Phenylalanine is the major ingredient in the artificial sweetener known as aspartame. Products containing this sweetener are required by law to carry warnings on their labels for phenylKETOnurics. People who have PKU can be severely injured by ingesting the sweetener. Products containing this artificial sweetener include diet sodas, sugarless gums and some sugar substitutes. Some sugar-free versions of Jello, puddings, ice creams, candies and various other items also contain aspartame.
Other Phenylalanine Uses:
Some individuals have reported that taking DL-phenylalanine has improved their mood and aided in treating depression. This is the result of a higher rate of production of the brain chemicals dopamine and norepinephrine. These chemicals, when out of balance, cause depression, stress and frustration. Elevation of the levels of these chemicals have an anti-depressant effect in the body.
One study suggests that D-phenylalanine has been shown to improve some symptoms associated with Parkinson’s disease. These include: depression, rigidity, walking problems and speech problems.
The combination of L-phenylalanine and UVA radiation may be used to treat the symptoms of vitiligo. This condition involves de-pigmentation (white patches) of skin. The use of L-phenylalanine may help to re-pigment these patches, but further study is necessary.
DL-Phenylalanine has many uses and benefits if taken correctly. As with any new dietary supplement, consult your physician before beginning a new routine.
Astaxanthin, a Member of the Carotenoid Family, is a Powerful Antioxidant
January 31, 2008 09:00 AM
Astaxanthin is a member of the carotenoid family responsible for the red color of many types of algae. Being a carotenoid, it is a powerful antioxidant and free radical scavenger as well as support proper eye function.
However, such a bland statement belies the true worth of astaxanthin in its fight against free radicals. It is of particular benefit in its ability to absorb the high energy of singlet oxygen, releasing it as heat, and returning the singlet oxygen to its ground neutralized state. Singlet oxygen is a particularly harmful and reactive oxygen species of free radical that is formed in the body as part of our normal metabolism, and that contains a high level of free energy that can be used to oxidize and destroy the cells of your body.
In achieving this, astaxanthin is regarded as one of the most potent plant derived antioxidants known, being up to ten times more active than beta carotene, Lutein or its cousin canthaxanthin. So why are antioxidants so valuable to our biochemistry and what would happen if they did not exist?
Free radicals are thieves that use your body as their operating ground. They operate by stealing an electron from a molecule that comprises part of you, and in some cases when this occurs the cell from which the electron is removed is destroyed. Generally electrons go around in pairs, but occasionally an electron pair can lose one of the electrons during a chemical reaction. Many such reactions occur naturally inside the body, especially during the production of energy from blood sugars in the mitochondria, and such a molecule containing a single unpaired electron is called a free radical. Free radicals are also generated by the reactive components of many pollutants such as traffic fumes and cigarette smoke, tars and pesticides, and also by the effect of UV radiation in sunlight.
The only purpose of a free radical is to steal an electron from the first source it can find. Such reactions occur very rapidly after the free radical has been generated, and if this electron belongs to another body cell, then the cell is destroyed leading to effects such as premature aging or even cancers. Free radical oxidation of the LDL lipids that carry cholesterol around the blood causes the deposition of fatty plaques inside arterial walls that eventually become constricted or even blocked, leading to heart disease or strokes.
That is why antioxidants that destroy these free radicals are so prized, and the more of them that there are in your body then the less affect the free radicals will have on you. You will retain your youthful looks longer, and will be less liable to suffer from heart disease, cancers, circulation problems and conditions such as diabetes. Many abnormal conditions can be laid at the door of free radicals.
The stronger the free radical, the more harm it can do to you and a strong antioxidant such as astaxanthin is a very powerful weapon in your armory against them. Astaxanthin is a member of the oxygenated xanthophylls, and its high level of antioxidant power likely comes from the KETOnic and hydroxyl functional groups of the ionone ring structure. It is more polar than most carotenoids, and this is a likely reason for its ability to span the cell membrane layers, with the active groups close to the hydrophilic-hydrophobic interface. They are thus more readily available at the sites where most free radicals tend to be found and provide immediate protection to the cell membrane and also to the intracellular mitochondrial membrane.
Many antioxidants destroy free radicals by donating an electron, and become oxidized themselves. Astaxanthin, however, does not do this, but instead adds the free radicals to its long double bonded chain hence avoiding oxidation and rendering it much more powerful than normal antioxidants. It is unusual among antioxidants in that it is also able to cross the blood-brain barrier, and so reduces oxidative stress that can cause neurological disorders in general, and also problems with eyesight. It can also attach itself to lipoproteins to enable it to be carried throughout the bloodstream, being available anywhere that free radicals are generated. The carotenoid is also active against active oxygen species that are responsible for inflammation.
Another property is its ability to neutralize the oxygenated free radicals formed by the photo-oxidation properties of UVA and UVB radiation. Included in these are the previously mentioned highly reactive singlet oxygen and also triplet oxygen that astaxanthin is able to neutralize without becoming oxidized. In fact reactive oxygen species in general can cause oxidative stress, and they have been thought responsible for many forms of disease and health conditions, and the powerful effect of astaxanthin in targeting many of these has led it to be regarded as highly beneficial to the immune system and to health in general.
Another benefit is the ability of the substance to help prevent the oxidation of high density lipoproteins (HDL) that are responsible for carrying cholesterol in the blood back to the liver for destruction. Free radical oxidation of HDL impairs its ability to transport cholesterol, and so decreasing the level of such free radical oxidation will by definition increase the quantity of good HDL available, and hence reduce the concentration of cholesterol in the blood. Studies have proved this to be the case, and astaxanthin supplements are very beneficial to those suffering from high blood cholesterol levels, and helps protect them from heart disease and strokes.
The substance is naturally available from a wide range of marine sources, such as lobsters (where it was first discovered), shrimp, salmon, trout and in a wide variety of red and green algae. The substance is also used as a red pigment. Carotenoids are essential, meaning that they are not produced in the human body and can only be obtained in our diets.
For that reason, the most convenient way to take it, apart from continually eating shrimp and lobster, is as a supplement. Astaxanthin is available either as a powerful antioxidant in its own right, or in combination with other substances with which it acts to provide a very strong deterrent to any free radicals that think they can freely roam your body.
7-Keto, The Next Dhea With No Side Effects
November 10, 2007 12:24 PM
7-KETO is a natural derivative of DHEA that is claimed to be free from many of the side-effects of regular DHEA supplements. DHEA is dehydroepiandosterone, which is the most abundantly produced of the adrenal hormones. After production in and release into the bloodstream by the adrenal glands that are situated just over the kidneys, DHEA undergoes metabolism to the male androgen hormones, and the female estrogens.
As you age, the production DHEA declines, starting at about 30, with a 50% decline by time you reach 40 and almost 85% at 70. This is true of the levels of many hormones in the body, though some, like the steroidal aldosterone, remain constant throughout life. The general rate of metabolism also reduces with age resulting in an even lower conversion rate of DHEA to the male and female hormones.
At the same time as this occurs, there also occurs a significant reduction in the biosynthesis of protein in the body, which results in a loss of muscle mass as you age, and also in the regeneration of bone tissue that results in what is commonly termed age-related osteoporosis. Brain cells die at an increasing rate leading to many neurological conditions and the immune system is also affected negatively.
Due to the concurrence of these aging effects, many scientists have related the general hormonal decline with the other effects of aging. The have asserted that if these hormones were restored, than many of the effects of aging could be delayed. Osteoporosis would be delayed due to the body’ s increased ability to restore lost bone mass, the metabolic rate would improve and fat would be burned at a faster rate and continue to build muscle, the brain would lose its functionality at a significantly lower rate and the immune system would continue to protect the body against disease.
In other words we might be able to live longer, but if not that then at least the quality of life would be maintained longer as we aged. This is a very welcome and desirable situation, but the taking of hormones as supplements has long been regarded as fraught with danger due to the possibility of undesirable side effects, some of them potentially very serious. DHEA was considered as one of these hormones that could be used as a supplement to achieve positive results in reducing these age-related changes because it exhibited these effects in tests on animals.
However, in order that a specific substance can be declared responsible for any metabolic improvement that involves liver biochemistry, some form of receptor has to be identified, and this failed to materialize in DHEA. There appears to be no such DHEA receptor, although that does not necessarily imply that DHEA is not responsible in some way. It might very well be a DHEA metabolite that is responsible, and that has still to be identified. It is certainly true that DHEA administered to both animal and human subjects has resulted in an increase in the testosterone and estrogen levels of the subjects. Such an increase is not desirable due to a number of potential side effects as previously inferred.
These are particularly liable to occur with people who already have an adequate level of natural DHEA production within their body. The side effects include acne, irregularity in the menstrual cycle, itchy scalp, increased body odor and an excess of androgenic hormones can lead to hair loss, or male pattern baldness. Interruptions in the heart rhythm, or palpitations, are another very serious side effect of DHEA supplementation, and high doses over a long period introduce a theoretical risk of certain cancers.
However, the discovery of 7-KETO, a natural derivative of DHEA claimed to be free from many of these side effects, has altered the situation. 7-KETO is a powerful antioxidant that speeds up the metabolism of fat and helps to reduce body weight. It also helps to replace lost fat with muscle mass, though it must be stated that this effect is only valid after the natural production of DHEA has slowed down. It is not a body-building supplement.
It was Professor Henry Lardy, of the Department of Biochemistry at the University of Wisconsin, who tested over 150 DHEA metabolites over 10 years and identified 7-oxo-dehydroepiandrosterone as having the greatest biochemical effect without having any detectable side effects. This material was trademarked 7-KETO by the Humanetics Corporation, and one of its known effects is to burn fat quicker by stimulating thermogenesis. It had also been shown to strengthen the immune system and to improve the memory. All of this without any measurable increase in any of the sex hormones. It was released after a careful and intensive series of safety tests on both humans and animals found it safe for human consumption.
It should be stressed that 7-KETO is not a hormone, and is not chemically the same as DHEA: it is a different chemical altogether that is produce when DHEA degrades in the body. Because of this it can be promoted as a non-androgenic or estrogenic form of DHEA. It is thought that all of the conditions that decline as we age that can benefit from a supplement of DHEA, will also benefit from a supplement of 7-KETO. However supplementation is only required from the ages of 25 – 30, when the natural amount of DHEA and 7-KETO in the body start to decline.
It causes neither high blood pressure nor any form of cancer, and was submitted to the FDA prior to being made publicly available. It is important to stress that the substance is neither a steroid nor does it metabolize to steroidal hormones, and is also not a sex hormone. It also has no effect on the body’s sex hormones. The whole point of 7-KETO is that it has the effect of DHEA without having any connection whatsoever with steroidal hormones or any hormonal substances. It is totally innocuous and safe to use, without the risk of heart palpitations, lost hair or any of the other side effects of DHEA.
Without a doubt, 7-KETO is a DHEA substitute that has none of the side effects of its precursor. So if you are over the age of 30 and feel the need for an energy boost, give 7-KETO a try.
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
KETOconazole - Topical KETOconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that KETOconazole exhibits other methods to its anti-hair-loss effect. One such theory of KETOconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, KETOconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% KETOconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% KETOconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with KETOconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with KETOconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with KETOconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength KETOkonazole where it was shown that use of 2% KETOconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as KETOconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
7-Keto - Anti-Aging and Antioxidant Protection
December 18, 2005 09:44 PM
“Anti-Aging and Antioxidant Protection”
The Fountain of Youth Discovered in Wisconsin
It turns out that Ponce de Leon was looking in the wrong place for the fabled Fountain of Youth. It was recently discovered – in Wisconsin! And it turns out that the Fountain of Youth isn’t really a fountain – it’s a biological compound produced in our own bodies. This compound is extremely important for the growth and development of the human body, and, as the body’s production of this substance decreases with age, the signs of aging begin to appear – weight gain, wrinkled skin, loss of muscle, loss of cognitive function, and loss of libido.
This biological Fountain of Youth was discovered by Dr. Henry Lardy and associates at the Institute for Enzyme Research at the University of Wisconsin. It’s called 7-KETO™, a metabolite of a hormone produced by the adrenal glands called DHEA (dehydroepiandrosterone). Research on 7-KETO™ indicates that it may work through a number of pathways to combat the signs of aging. Helping the body maintain a healthy weight as we age greatly improves overall health and longevity and is one of the strongest benefits discovered for 7-KETO™ to date.
Unfortunately, because 7-KETO™ is a metabolite of DHEA, whose levels decline as we age, so to does this wonderful, natural bio-nutrient. Scientists originally looked to DHEA for improved cardiovascular vitality, and strengthened immune and brain function3. Researchers believed that declining DHEA so profoundly impacted our bodies that it could be partly responsible for the effects of aging. They hypothesized that supplementation with DHEA could sustain hormone levels and stave off many of the degenerative changes we collectively call aging. But there was a catch. Because DHEA is converted into sex hormones, people taking supplemental DHEA would sometimes experience the frightening, unwanted side effects associated with hormone supplementation.
In 1989, Dr. Lardy and his colleagues set out to solve the mystery of eliminating DHEA’s side effects by examining all of the constituents that make up DHEA. Ten long years of research unearthed hundreds of DHEA derivatives, which were developed and tested continuously, until one derivative rose above all the others – a metabolite that was incredibly bio-active and far more promising than any other substance they’d tested. That metabolite is 7-KETO™. 7-KETO™ outperformed DHEA and other metabolites in immune modulation, memory enhancement and thermogenesis and, more importantly, without any adverse side effects3.
The most significant benefit of 7-KETO™ supplementation is its ability to support healthy body weight. Obesity is a major contributing factor in a number of serious medical conditions. A recent study assessed the effectiveness of 7-KETO™ on weight loss and body fat loss. Participants were divided into two groups; one group received 100mg of 7-KETO™ twice daily and the other a placebo. Both groups exercised three times per week. At the end of the study, researchers noted a statistically significant reduction in body weight and body fat only in the 7-KETO™ group. Researchers concluded that 7-KETO™ was three times more effective than diet and exercise alone in promoting weight and fat loss1,2,7. Preliminary research also indicates that 7-KETO™ may support healthy immune and nervous systems. One study measured the effects of 7-KETO™ on memory function. Subjects were given a single dose of a substance that inhibits nerve cell communication and causes shortterm memory loss. Afterwards subjects were given a single dose of 7-KETO™. Results showed that 7-KETO completely reversed the memory impairment, suggesting that 7-KETO™ supports memory retention6.
Another study gauged 7-KETO™’s ability to support immune system function. Interleukin 2 (IL2) is a substance produced by T lymphocytes that causes an increase of disease fighting white blood cells. White blood cells were taken from healthy volunteers and introduced into a solution that contained 7-KETO™ for 24 hours. When the cultures were tested for heightened IL2 production. 7-KETO™ was shown to augment IL2 production by a statistically significant 68%4.
NOW® 7-KETO™ is a well-researched and patented form of this amazing product that’s supplied by the Humanetics Corporation. Humanetics 7-KETO™ has been proven safe and well-tolerated in doses up to 200mg5. Research is clear, the rate at which we age can be influenced by the diet and lifestyle choices we make. One very smart choice would clearly be adding NOW 7-KETO™ to your diet.
1) 7-KETO™: The Key to Healthy Aging – Scientific Support; Humanetics Corporation, 1999
NOW is the leader in quality and value
October 21, 2005 08:12 AM
NOW is the leader in quality and value
“We only deal with companies that support the natural products industry and have a strong public service mission”
We couldn’t agree more. NOW has, and will continue to fight for the rights of consumers to take safe supplements. As one of the most active and influential advocates in the natural products industry, we proudly support the following industry organizations.
NFA, Citizens for health, AHPA, OTA, The Herb Research Foundation, The American Botanical Council, Consumers for Health Choice (UK), The GMO Task Force, The GMP Task Force, American Herbal Pharmacopoeia, The Campaign to label Genetically Engineered Foods, AOAC (method validation), AOCS (American Oil Chemist Society), The Dietary Supplement Education Alliance (DSEA), and More…
“Does NOW support any Charitable or public services?”
NOW is a leading recycling company and was awarded a silver medal for nutrition business journal in 2005 for our dedication to environmental and sustainability issues. We use environmental-friendly packaging and procedures to ensure that our impact on the environment is minimal. Here are just a few of the charities and originations NOW generously supports:
Local Heal Clinics and food banks, Salvation Army, Marklund children’s home, African meal-a-day fund, compassion international, vitamin angel, world relief, Indian orphanage, Hephzibah children’s home, nature conservancy, Americas second harvest, world wild life, and many more
New antibiotics expected for resistant pneumonia bugs
October 10, 2005 11:52 AM
New antibiotics expected for resistant pneumonia bugs
Scientists recently announced the expected arrival of a new family of bacteria-killers on the horizon for pneumonia and other diseases. These new antibiotics should offer an alternative to standard antibiotics, many of which have lost their punch against increasingly resistant germs.
The standard treatment today for many bacterial infections that cause respiratory diseases are medicines called macrolides. These include well-known antiobiotics like penicillin and erythromycin. However, certain bacteria strains are growing resistant to them, as well as to the primary back-up medicines, known as quinolones.
The pharmaceutical industry's response to this problem is KETOlides. KETOlides are derived from macrolides, but since they have a different chemical composition, they will kill bacteria that are resistant to macrolides. Researchers recently presented reports on two varieties of KETOlides at an infectious diseases meeting sponsored by the American Society for Microbiology. Aventis Pharmaceuticals recently filed with the U.S. Food and Drug Administration to gain permission to sell a new KETOlide antibiotic, Ketek, or telithromycin. A similar drug made by Abbott Pharmaceuticals, code named ABT-773, is also in the early stages of human testing.
Researchers presented new Ketek studies involving 2,500 patients. These reports intended to show how the once-a-day Ketek is equally effective as other standard antibiotics in treating many bacterial diseases, including pneumonia, bronchitis, sinus infections and sore throats. Scientist also say since the Ketek treatment lasts just five days, which is shorter than most antibiotic treatments, bacteria may be less likely to grow resistant to the new drug.
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)
August 02, 2005 03:52 PM
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.4
Thiamine and its Co-enzyme, TPP
Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.
Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites.
As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.5 In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves.
Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transKETOlase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranKETOlase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* TransKETOlase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transKETOlase activity in bovine aortic endothelial cells incubated in glucose.6 To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transKETOlase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.6
Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs).
AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food.7 At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated.8 It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs.9 Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin.10 Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter.
Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transKETOlase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage.11
Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.3,12 The statements in this fact sheet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Bitsch R, Wolf M, Möller J. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab 1991;35(2):292-6.
2. Schreeb KH, Freudenthaler S, Vormfelde SV, et al. Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. Eur J Clin Pharmacol 1997; 52(4):319-20.
3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther 1996;34(2):47-50.
4. Frank T, Bitsch R, Maiwald J, Stein G. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Eur J Clin Pharmacol. 2000;56(3):251-7.
5. Pike RL, Brown ML. Nutrition, An Integrated Approach, 3rd Ed. New York:MacMillan; 1986:467.
6. Hammes H-P, Du X, Edlestein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic neuropathy. Nat Med 2003;9(3):294-99.
7. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci 1984;81(2):583-7.
8. Brownlee M. The pathological implications of protein glycation. Clin Invest Med 1995;18(4):275-81.
9. Pomero F, Molinar Min A, La Selva M, et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol 2001;38(3):135-8.
10. Stracke H, Hammes HP, Werkman D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 2001;109(6):300-6.
11. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 2003;52(8):2110-20.
12. Bergfeld R, MatsumaraT, Du X, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia induced mitochondrial overproduction of reactive oxygen specifies and experimental diabetic neuropathy (Abstract) Diabetologia 2001; 44(Suppl1):A39.
THE FDA AND NON-CALORIC SWEETENERS
July 15, 2005 12:27 PM
THE FDA AND NON-CALORIC SWEETENERS
While white sugar, turbinado, fructose, honey and corn syrup all qualify as natural sweeteners, none of these are calorie- free nor can they be used by people who suffer from blood sugar disorders. They can encourage weight gain, tooth decay, raise blood sugar quickly, and can also predispose certain individuals to yeast infections. These sugars can also contribute to indigestion, bowel disorders and, possibly, hyperactivity or ADD in children. Pharmaceutical sweeteners like aspartame and saccharin qualify as calorie-free but come with significant limitations and health risks. Saccharin has been labeled with a warning that it has caused the development of cancer in laboratory animals but is still available for purchase. In 1970, cyclamates, another class of artificial sweeteners, were banned because of the strong possibility that they are, in fact, carcinogenic. Aspartame has been marketed as a safe substance for the general public, except for those few individuals who suffer from PKU (phenylKETOnuria), a relatively rare disorder. Most consumers assume that aspartame is a perfectly benign compound and use it liberally. It is, in fact, comprised of phenylalanine, aspartic acid, and methanol (wood alcohol). As previously mentioned, various side effects have been associated with the ingestion of aspartame and include migraines, memory loss, slurred speech, dizziness, stomach pain, and even seizures.
In addition, because aspartame contains chemicals which affect brain cell function, significant questions have been raised concerning its link to increased incidence of brain tumors (Olney). Acesulfame K, another artificial sweetener on the market, has also been linked to cancer by the Center for Science in the Public Interest. Despite the protest of various organizations and health professionals, these pharmaceutical s weeteners have been approved by the FDA and are recognized as safe.
7-Keto - The Key to Healthy Aging
June 21, 2005 05:05 PM
The global population is aging at an alarming rate and causing an explosion in health care costs, insurance premiums, cosmetic surgery and more. In the U.S. alone, more than one million baby boomers are expected to live to 100 years of age or older. This increased life expectancy presents a whole new set of health concerns that the medical community has not had time to address, since there is a greater need to care for age-related health problems in this ever-growing elderly population.1
Aging and the Decline in Vital Nutrients
We all grow old at the same rate but people age at different rates. Aging is a process of gradual changes that occur to varying degrees in each of us. Interestingly, the aging process is composed of different components and interactions, some of which can be impacted. One such component is the declining level of essential biological compounds, which causes our bodily functions to slow and become dysfunctional. Our organs don?t work efficiently, our immune system becomes lazy, we lack energy, our metabolism drops and we gain weight easily.1 7-oxo DHEA (7-KETO™) is a naturally occurring compound that declines with age.2 Replacing this key metabolite helps promote a healthy immune system and maintains resting metabolic rate at levels that accelerate weight loss during standard weight reduction programs.
Aging and a Healthy Immune System
Numerous changes occur in the immune system with advancing age, probably contributing to decreased immune responsiveness. Although all segments of the immune system are affected, investigators have most consistently identified declines in cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is generally associated with an increased susceptibility to foreign organisms. For example, individuals with age-related declines in cellular immunity have an impaired response to vaccinations, making them more susceptible to health imbalances even though they have had their shots. In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-KETO on elderly immune function was evaluated. Healthy elderly adults were given 7-KETO orally twice daily over a period of one month. The study revealed that 7-KETO augmented several key T-cell mediated immune function parameters compared to placebo administration.4
Age-Related Weight Gain
Age-related weight gain and obesity are approaching epidemic proportions in our country.5 Weight gain is a disorder of energy balance involving energy intake and/or expenditure. Low energy expenditure, a drop in resting metabolic rate (RMR), is a challenge during most weight loss attempts due to age, calorie restriction, lack of physical activity or a combination of factors. RMR represents 60% of total daily energy expenditure. Maintaining a higher RMR as we age and during weight reduction programs helps us achieve and maintain a normal weight. Furthermore, compounds with the thermogenic potential to achieve even minimal increases in daily energy expenditure of 2-3% may have clinical relevance in preventing the decline in RMR with calorie restricted diets or weight loss, and in decreasing the risk of regaining weight. 7-KETO, a non-stimulant thermogenic compound, has been shown to significantly increase energy expenditure in humans.6 A recently completed clinical study, also presented at the Federation of American Societies for Experimental Biology 2004 meeting, revealed that administration of 7-KETO to overweight adults in conjunction with a calorie restricted diet effectively reversed the decline in RMR normally associated with dieting. Obese participants following a calorie-restricted diet demonstrated a 5.4% increase in daily RMR with 7-KETO.7 The magnitude of the increase in RMR by 7-KETO is clinically relevant, and represents a promising agent for enhancing thermogenesis and weight loss in obese individuals on calorie-restricted diets. Additionally, 7-KETO has been shown in two confirmatory published clinical studies to result in three times more weight loss compared to diet and exercise alone. It has a favorable side effect profile and is easy and convenient to take.8,9 Our life expectancies will likely be longer than those of our parents, and our quality of life during those years will depend on how well we take care of our bodies now. Undoubtedly, the science of aging will give rise to new and exciting technologies to help us age more gracefully and healthfully. Maintenance of healthy immune function is keenly needed for improved quality of life in the elderly. Dietary manipulation and supplementation has been identified as a method of immune system renewal, and supplements such as 7-KETO may play an important future role as immune system modulators. Moreover, the addition of 7-KETO to any weight loss program will offer vital support of energy expenditure and help with the attainment of a manageable and healthy weight into our older years.
1. 1995 White House Conference on Aging, ?Executive Summary: The Road to an Aging Policy for the 21st Century," February 1996: 17-18. 2. Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-KETO-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrinol. 1979; 25(4): 28-31. 3. Ginaldi L, De Martinis M, D?Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological Changes in the Elderly. Aging 1999; 11(5): 281-286. 4. Zenk JL, Kuskowski MA. The Use of 3-acetyl-7-oxo-dehydroepiandrosterone for Augmenting Immune Response in the Elderly, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and Trends in Obesity Among US Adults. 1999-2000. JAMA 2002;288:1723-1727. 6. Astrup A. Thermogenic Drugs as a Strategy for Treatment of Obesity. Endocrine 2000;13(2):207-212. 7. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA. A Prospective, Randomized, Double Blind Study to Evaluate the Effect of HUM5007 and 7-oxo DHEA on Resting Metabolic Rate in Overweight Adult Men and Women on a Calorie Restricted Diet, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 8. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A Randomized, Double-Blind, Placebo Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current Therapeutic Research 2000;61: 435-442. 9. Zenk JL, Helmer TR, Kassen LJ, Kuslowski MA. The Effect of 7-KETO Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research 2002; 63:263-272.
John L. Zenk, M.D., is Chief Medical and Scientific Officer for Humanetics Corporation and President and Medical Director of Minnesota Applied Research Center, both located in Eden Prairie, MN. He has spoken nationally and internationally on the subjects of integrating conventional and complementary medicine, anti-aging technologies, evaluating the effectiveness of alternative medicine, and dietary supplement research and development. He is author of the book Living Longer in the Boomer Age, and co-author of the book Age Wise and is a frequent contributor to national media. He has served as Principal Investigator for 15 controlled clinical studies, three of which were recently published in national peer-reviewed journals, and has presented abstracts at the 11th World Congress for Food Science and Technology and the Federation of American Societies for Experimental Biology.
Enhancer for Youthful Vitality
June 16, 2005 08:20 PM
NEW PRODUCT ANNOUNCEMENT
Enhancer for Youthful Vitality
Five tablets contain:
Suggested Use: 5 tablets before exercise and/or at bedtime with plenty of water at least two hours after the last meal. Discontinue use or reduce dosage if any of the following symptoms are present: nausea, excessive salivation, vomiting, diarrhea, muscle spasms, cramps, excessive urination, insomnia, headache, cardiac arrhythmias, high blood pressure, or changes in mood or emotional balance.
Building the Burn
June 14, 2005 12:09 PM
Building the Burn by Marjorie Flakowitz Energy Times, June 11, 2004
When was the last time you exercised? During the past decade, the number of obese Americans has jumped by 50%. A big factor in this increase: lack of physical activity.
Today, technological society seems to make everyday life effortless: car windows retreat at the push of a button, remote controls keep couch potatoes from budging off the cushions and video games have replaced non-cyber ball playing. Americans don't move around and burn off the calories they eat. Instead, our sedentary ways are causing big stomach bulges and a big bulge in health problems linked to being overweight.
Want to lose those pounds? Consuming the right nutrients and pounding the pavement are a great start.
Number of Large Americans Grows Larger
Fifty-five out of every 100 Americans are now overweight. And the numbers continue to surge. To take yourself out of these alarming statistics, plan a consistent exercise program. If the thought of sweating during strenuous workouts at the gym scares you, relax. You don't have to do that much. According to a long list of research, a few half-hour walks a week can put you on the road to weight loss.
For instance, researchers at Duke found that walking a total of only 12 miles a week can help you control your weight even if you're not dieting (Archives of Internal Medicine 1/12/04). Of course dieting and taking the right supplements will help you lose weight a little faster, but walking burns off the pounds.
In the study at Duke, scientists gathered about 180 overweight, sedentary people and assigned them to one of four groups. The first group had to jog about 20 miles a week. The second group jogged 12 miles a week. The third group walked 12 miles, and the last group didn't do a thing.
" We found that the two low-exercise groups lost both weight and fat, while those in the more intensive group lost more of each in a 'dose-response' manner," says Cris Slentz, PhD, one of the researchers. " Simply put, the more you exercise, the more you benefit. Just as importantly, the control group of participants who performed no exercise gained weight over the period of the trial."
Everybody who was exercising lost weight; their stomachs and hips shrank. The folks who did nothing didn't just stay at the same weight; their weight went up.
Dr. Slentz adds, "From the perspective of prevention, it appears that the 30 minutes per day will keep most people from gaining the additional weight associated with inactivity. Given the increase in obesity in the US, it would seem likely that many in our society may have fallen below this minimal level of physical activity required to maintain body weight."
Of course, limiting the carbohydrates you consume and eating more protein at the same time as you exercise can help you lose weight more effectively. To help your body utilize protein more fully to fuel your exercise, many experts recommend taking enzyme supplements.
One of the most valuable enzyme combinations in this process is Aminogen(r), an all-natural, patented plant enzyme that assists the digestive tract in liberating the amino acids that are the building blocks of dietary protein. By helping separate these amino acids, absorption is boosted through the walls of the small intestines and your metabolism is better able to take up proteins and use them.
Add Chromium to Exercise
The mineral chromium is another supplement found helpful in aiding weight loss. An eight-week study at the University of Texas, Austin, compared weight loss among obese women who exercised and took chromium with the number of pounds that were lost by women performing the same amount of exercise without taking supplements (Medicine & Science in Sports & Exercise 1997; 29:992-8).
The result: women taking chromium lost a significantly greater amount. How does chromium work? A study at the University of Vermont found that chromium may help muscles take blood sugar (glucose) out of the blood more effectively by improving what's called insulin sensitivity (18th International Diabetes Federation Congress, Paris, 8/03).
Insulin is released by the pancreas to help cells take in glucose. By exercising and keeping your weight down, and becoming more insulin sensitive, you potentially reduce your chances of getting diabetes. The cells quickly respond to insulin and blood sugar stabilizes.
On the other hand, when insulin sensitivity drops significantly, the body may suffer what's called insulin resistance, a pre-diabetic condition that complicates and slows the removal of sugar from the blood. The Vermont researchers found that chromium increases the activity of a protein called Akt phosphorylation. This is a natural substance made by the body that makes cells more sensitive to insulin and speeds the movement of blood sugar into cells, where it can be burned for energy. So, in combination with exercise, which also helps the body become more responsive to insulin, chromium may help keep blood sugar under control.
As Sandra Woodruff points out in her book Secrets of Good Carb, Low Carb Living (Avery/Penguin), "[P]hysical activity boosts the body's ability to process carbohydrate and helps reduce insulin resistance....Exercise acts much like an insulin-sensitizing drug to make the body's cells more responsive to insulin, which enables them to remove sugar from the blood more efficiently." The results of exercise and getting sufficient chromium can help support weight loss and healthy blood sugar levels. The Vermont research team found that the exercising chromium takers boosted their insulin sensitivity by almost 9%.
Building a Lean Body
A prime benefit of exercising while you lose weight is that physical activity builds muscle tissue. Muscle tissue, even at rest, burns more calories than fat cells, so having extra muscle means you can eat more and still maintain or lose weight. An aid in this process is Coleus forskohlii root, Benth., a plant that originated in India. Research shows that forskohlii furthers molecular energy processes within cells that support the development of lean body tissue (muscle) and the enzymatic reactions that break down fat.
In a study of about two dozen women who took forskohlii extract, researchers found that taking this supplement was associated with feeling more energetic and less hungry (Experimental Biology meeting, 2002). According to Vladimir Badmaev, PhD, who has studied forskohlii, this herb's help in supporting lean body tissue is crucial to maintaining a healthy weight.
" In highly overweight individuals, fat tissue can constitute up to 70% of body weight. The remaining proportion of body composition corresponds to the lean body mass. Lean body mass is composed of muscle, vital organs, bone, connective and other non-fatty tissues in the body," says Dr. Badmaev.
" The body's metabolic rate is in direct proportion to the amount of lean body mass. Therefore, safely maintaining or increasing lean body mass is an important consideration for any weight-loss strategy."
The Skinny on Calcium
Calcium, long known for its ability to strengthen bones, is now turning out to play a key role in weight maintenance as well. In one study, obese mice who were put on calorie-restricted diets lost body fat when fed extra calcium (Experimental Biology meeting 2000). Both supplemental calcium and low-fat dairy proved effective. What's more, low-fat dairy's ability to burn fat and provoke fat loss have been confirmed in additional research (Obesity Research 4/04; 12:582-90).
Fat cells contain calcium, and scientists believe that the more of this mineral a fat cell contains, the more fat will be burned off. This action is especially important when you cut back on calories, since that often gives your body the idea that it's starving, leading your metabolism to slow and making weight loss extremely difficult.
A Complete Program
To lose weight efficiently, stay in top shape and retain your feelings of energy, you also have to make sure you get enough of the vitamins and minerals necessary for good health.
For those eating a high-protein diet who are limiting their fruits and vegetables, taking a supplement that incorporates nutrients from fruits and vegetables can help restore your feelings of well-being and help maintain your motivation for dieting and losing weight. (Supplements are available that deliver these nutrients without carbohydrates.)
In addition, supplements of what are called KETOgenic amino acids-the natural substances that form protein's building blocks-can also help fuel your weight-loss program. These special nutrients can be efficiently used for the body's energy needs, a process that helps you lose weight.
And don't forget to keep moving! Soon you may have the kind of results researchers produced at the University of Pittsburgh when they studied women who exercised 40 minutes, five times a week (Journal of the American Medical Association 9/10/03). Those women lost 25 pounds in six months.
Your results may be just as good or better!
Higher Mind - Smart Nutrients for the Performance of a Lifetime...
June 02, 2005 12:18 PM
Our adult years are the time to reap the fruit of an active, meaningful life – appreciated by family and friends who value our experience and knowledge. For some, however, their later years are clouded by a mental decline that erodes their capacity to enjoy life. More of us are becoming apprehensive about the future health of our minds. Will we still be able to communicate our needs as well as our wisdom? As science focuses its investigative might on the workings of the human brain, new findings suggest that it is possible to enjoy a vital, healthy brain and mind – well into old age. Based on compelling research, Source Naturals formulated HIGHER MIND. It contains the most important Neuroceuticals™ now recognized by nutrition scientists – including phosphatidyl serine, a natural nutrient that promotes cognitive function. The connection is clear: nourish your brain; enrich your life.
To have a healthy, well-functioning brain and nervous system, we need the correct nutrients. Our diets must provide the necessary raw materials for nerve cells to grow, for the synthesis of neurochemicals, and for the maintenance of nerve cell membranes. Nutritional deficiencies can alter the brain’s metabolism, which is expressed by changes in perception and thinking, behavior and mood.
Brain Cells – Issued at Birth
Before birth, neurons (nerve cells) are created at the amazing rate of 15 million per hour. As infants, we have over 100 billion neurons, but this is the most we will ever have because – unlike most other cells in our body – nerve cells do not reproduce. A different strategy is used to replace the neurons that are naturally lost throughout life: nerve cells repair themselves and grow by extending branches of nerve fibers called dendrites (from the Latin word for tree). These are the communication links with other neurons that form the circuitry of the brain. A single neuron may be in contact with up to a hundred thousand others! When the density of this fragile organic communication network decreases, we experience a corresponding decline in mental acuity.
Brain Cell Membranes
The membrane is the working surface of a cell. It needs to be strong yet flexible, so the cell can maintain its integrity and be able to move and change shape. The membrane regulates the flow of nutrients into the cell and the removal of waste, plus controls the passage of molecular messages from outside the cell to its interior. Membrane ion pumps use a third of the cell’s energy just to maintain the correct ratio of sodium to potassium. In neurons, a rapid exchange of sodium and potassium ions across the nerve membrane is responsible for their unique ability to generate the electrical impulses that are the basis of all communication in the nervous system. As cells age, their membranes become less fluid and more rigid. Key membrane molecules called phospholipids are crucial to the health of neuron membranes, allowing the brain to maintain its youthful quality. The phospholipids in HIGHER MIND – especially phosphatidyl serine and phosphatidyl choline – are essential nutritional supplements for the aging brain.
Phosphatidyl Serine – Key to Cognition
For the past decade, researchers have been investigating the role in brain health of a remarkable neuroceutical, phosphatidyl serine (PS). This key structural molecule is integral to the matrix of fats and proteins that compose cell membranes. Although PS is found in all the cells of the body, its highest concentration is in nerve cell membranes. PS is rarely found in the foods we eat, so the body has to synthesize it, but the process is energy- intensive and becomes less efficient with age. Consequently, our levels of PS tend to decline as we get older. PS taken as a dietary supplement is well-absorbed, readily reaching the brain, where it helps create more effective, well-structured nerve cell membranes. The positive effects of PS supplementation have been demonstrated by 23 clinical studies with over 1200 human subjects, ages 43 to 90. Consistent and statistically significant results have confirmed the value of PS in improving age-related cognitive decline, as well as in improving behavioral aspects such as apathy and withdrawal.1 A major study concluded that for one particular measurable parameter of higher mental functions, PS recipients achieved scores of persons roughly 12 years younger.2 Nerve Growth Factor (NGF) is one of the most important proteins the body makes. It enables neurons to extend dendrites out to other neurons, allowing the brain to maintain an effective communication network. In experiments, PS enhanced the production and reception of NGF, which tend to drop off radically with age.3 The effects of PS at the cellular level are manifest in the performance of the brain as a whole. Subjects taking PS showed increased levels of brain energy metabolism. This enhancement corresponded to higher performances on cognitive tests.4
The Chemistry of Thought
Science now understands the role of neurotransmitters in regulating the body’s complex network of behavior. Neurotransmitters are the chemicals used by neurons to communicate with each other. Activated by a neuron’s electrical impulse, neurotransmitters travel between nerve cells, where they excite or inhibit (in various degrees) the electrical impulse in neighboring cells. One of HIGHER MIND’S key strategies is to improve the brain’s ability to produce and use acetylcholine, a key excitatory neurotransmitter. Acetylcholine is essential for both the storage and recall of memory, and partly responsible for concentration and focus. It also plays a significant role in muscular coordination. Patients showing cognitive decline may exhibit reduced ability to synthesize and utilize acetylcholine.5 The chemical building blocks of acetylcholine and other neurotransmitters are called precursors. The most important one for acetylcholine is DMAE (dimethylaminoethanol). This natural substance is found in various fish, such as anchovies and sardines. Supplements of DMAE (and phosphatidyl choline) promote increased levels of choline in the brain. Acetylcholine is created when an acetyl group is attached to the choline molecule, with the help of choline acetyl transferase (CAT), a key brain enzyme. Acetyl L-carnitine is an amino acid that activates this enzyme. Acetyl L-carnitine may also help reduce lipofuscin deposits in the brain because of its involvement in the metabolism of fatty acids.6 Lipofuscin is composed of oxidized fats and proteins; the brown “age spots” on the back of an elderly person’s hand are made of lipofuscin. The amino acid L-pyroglutamic acid sensitizes the acetylcholine receptor sites on a neuron membrane. A given amount of acetylcholine will then have a larger, more powerful effect. Studies have shown that supplements of L-pyroglutamic acid seem to enhance the ability to focus, remember, and learn.
Total Nutrition for the Brain
The neurotransmitters dopamine and noradrenalin are critical to motor coordination, motivation, concentration, and alertness. Like acetylcholine, their production tends to decline with age. The precursors and activators of dopamine and noradrenalin included in HIGHER MIND are the amino acids N-Acetyl L-Tyrosine and DL-phenylalanine (DLPA), plus folic acid, vitamins B-3, B-6, and C. DLPA is also a precursor to PEA, a neuroamine that has a stimulating effect on the brain. Glutamine is an amino acid precursor to glutamic acid, a major excitatory neurotransmitter involved in mental activity and learning. Glutamine acts as an alternative fuel source for the brain when blood sugar levels are low. It also helps the brain dispose of waste ammonia, which is a natural result of protein breakdown but is irritating to neurons even at low levels. GABA is a dietary amino acid which is also an inhibitory neurotransmitter. GABA works to calm and balance the mind, enhancing mental focus. Along with taurine, these two relaxing neurotransmitters provide a balancing influence to the other, excitatory neurotransmitters. Taurine is found in brain tissue more than anywhere else in the body. It has antioxidant properties and serves as a nerve cell membrane stabilizer, preventing excessive or erratic electrical activity in the brain.
The Importance of Magnesium
Magnesium must be present in adequate amounts in the synaptic gaps between neurons or the neurons become hyper-reactive: causing noises to sound excessively loud and emotional reactions to be extreme. Magnesium also activates a key enzyme responsible for maintaining cellular sodium- potassium balance, which is absolutely essential to the electrical activity of nerve cells, as well as to the existence of the cell itself. (Cells would burst if the sodium-potassium ratio were wrong.) Magnesium also helps relax cerebral blood vessels and is important to the manufacture of ATP, the chief energy molecule of the brain. A buildup of aluminum has been found in the brains of some elderly. In 1989, the British medical journal Lancet published a study showing that drinking water with aluminum can increase the risk of damage by up to 50%. An abundant natural element, aluminum is now a common feature in our culture. It’s found in tap water, cookware, deodorants, beverage containers, baked goods, and of course as aluminum foil. In the brain, aluminum breaks down the structure of neurons – causing them to starve – by displacing magnesium from tubulin, a glycoprotein responsible for making microtubules. These tiny pipe-like structures within a neuron provide needed rigidity, as well as transport nutrients from the nucleus down the dendrites to the ends of the nerve cell. Magnesium malate is an excellent form of magnesium that ensures neurons receive this vital mineral.
B is for Brain Vitamins
HIGHER MIND also contains a high profile of B vitamins and other key nutrients that are often N A T U R A L S S O U R C E Strategies for Wellness SM ¤ lacking in older individuals. A deficiency in any of the B vitamins can alter nerve function and psychological well-being. Thiamine (B-1), known as the “nerve vitamin,” was first recognized because its deficiency caused beriberi, a degenerative nerve disease. Thiamine is part of the structure of nerve cell membranes and is important to the reparative process that neurons need to offset the stress of continual firing of the electrical impulse. Low amounts of thiamine can cause cell malnutrition in the hypothalamus, the brain’s memory center. 7 NAD and NADH, two coenzyme forms of Niacin (B-3), are the most plentiful coenzymes in the brain. They are essential to hundreds of enzymatic reactions, including ones that produce energy. NADH can stimulate the synthesis of key mood-elevating neurotransmitters. It is also one of the body’s most potent antioxidants. Pantothenic acid (B-5), cyanocobalamin (B-12), and folic acid are required to form the myelin sheath – the insulating covering of nerve fibers. A diet low in pantothenic acid has been shown to make test subjects emotionally upset, irritable, and depressed.7 A lack of B-12 can result in poor concentration and, in severe deficiencies, hallucinations. Pyridoxine (B-6) is precursor to over 60 enzymatic reactions and is involved in the synthesis of several neurotransmitters.
Brain cells almost exclusively burn glucose for their energy (other cells can also burn fat), and typically require 50% of all the glucose in the blood. Two B-like vitamins help in the utilization of glucose: PAK (pyridoxine alpha-KETOglutarate) may potentiate the effects of insulin and improve glucose utilization to the cells;8 Biotin is important for the transformation of glucose into energy in the brain. Lipoic acid and coenzyme Q10 are metabolic energizers that help produce ATP, the primary energy molecule in the body. Since the brain uses 20% of the body’s total energy supply, efficient ATP production is vital. Lipoic acid and CoQ10 are also powerful antioxidants that help regenerate other antioxidants in the body. The blood vessels feeding the brain become less efficient as we pass middle age. Since the brain depends on the bloodstream to deliver nutrients and oxygen and to remove waste, the quality of this blood flow is paramount to proper brain nutrition. Ginkgo biloba leaf extract has been shown in scientific studies to increase blood flow to the brain by helping vessels to dilate. It also promotes the smoothness and healthy integrity of blood vessel linings.
For the Life of Your Mind Without proper nutrition, the brain will deteriorate; therefore strategies are needed to both enhance current brain function and protect it throughout life. Based on the latest scientific findings, Source Naturals HIGHER MIND is formulated with neuroceuticals that support the mental functions that tend to decline with age. They give your brain the nourishment it needs to integrate perception, memory, and learning into a more comprehensive awareness – so you can excel for a lifetime.
Elan Vital - The Vital Essence of Life - Multi-Vitamin and Mineral Supplement
June 01, 2005 01:13 PM
What makes ÉLAN VITÀL unique is its unprecedented range of nutriments in high potencies and superior forms. Quite simply, it stands alone among multiples: a quantum leap beyond maintenance...into excellence. Not only does it offer unparalleled antioxidant nutrition and a full-spectrum of essential vitamins and minerals, ÉLAN VITÀL is also formulated with specific nutrients that support:
Today’s inflated levels of stress and pollution give rise to harmful free radicals – unpaired electrons that can damage living cells and compromise the proper function of tissues and organs. Antioxidants serve to protect the body by neutralizing free radicals; in fact, many scientists believe that high levels of antioxidants may prolong the effective working life span of the body’s cells. The primary strategy of ÉLAN VITÀL is to provide a wide range of antioxidants at exceptional levels, from both botanical and biochemical sources.
ÉLAN VITÀL has the powerful advantage of Plantioxidants™, standardized botanical extracts with unparalleled free radical-scavenging properties. Plantioxidants have the unique quality of providing targeted protection because they tend to be attracted to different organs in the body. Grape Seed extract is rich in potent proanthocyanidins, a special class of highly bioavailable, water-soluble bioflavonoids that have the unique ability to cross the blood-brain barrier where they support the health of brain cells. Proanthocyanidins have been shown to efficiently scavenge oxygen radicals, as well as optimize the transport of vitamin C. They also have an affinity for collagen and elastin, the structural proteins that are abundant in vessel linings and other connective tissue. ÉLAN VITÀL contains the most concentrated extract of Bilberry available, with at least 25% anthocyanosides – compounds which are similar to proanthocyanidins but with an unusually strong attraction to optical tissue. They have been shown to protect cellular integrity in the delicate structures of the eyes. Ginkgo biloba extract is a standardized concentration of prime quality ginkgo leaves, yielding 24% ginkgoflavoneglycosides. These active compounds are potent antioxidants that have been associated with superior oxygen transport throughout the body with a special affinity for brain capillaries. Silymarin is the name given to a complex of three bioflavonoid-like compounds — silybum, silycristin, and silymarin — extracted and concentrated from milk thistle seeds. Silymarin functions in the body as an antioxidant with a special attraction for the liver. It has been researched and used extensively in Europe, where it is prized for its unique ability to nourish the liver and support its natural regeneration process by speeding up DNA synthesis in liver cells. Quercetin is a bioflavonoid present in some foods, such as onions and blue-green algae. A cousin of rutin, quercetin has been shown to stabilize cell membranes and help prevent free radical damage to this vital but vulnerable part of cells. Bioflavonoids and related compounds do their best antioxidant work when in the presence of Vitamin C, the nutrient they are most often paired with in nature. The vitamin C provided in ÉLAN VITÀL is both water- and fat-soluble. This combination is crucial because the tissues and membranes richest in fatty acids are most at risk to free radical attack. Fat-soluble vitamin C in the form of ascorbyl palmitate has an affinity for these highly vulnerable structures.
ÉLAN VITÀL not only provides botanical defense plants to combat free radicals, but also contains tried-and-true antioxidant nutrients: Biochemicals known as vitamins, minerals, and amino acids work together for maximum protection to all the body’s cells. The amino acid, N-Acetyl Cysteine, is a powerful and highly versatile antioxidant that doubles as a precursor to glutathione and glutathione peroxidase, two of the most formidable cell-protective compounds manufactured by the body. Studies have shown that supplemental N-acetyl cysteine enhances internal levels of glutathione far better than supplements of glutathione itself. Methionine also contributes to the synthesis of glutathione, and is an efficient transporter of certain antioxidant minerals, magnifying their activity. Vitamin A is included in both its fat-soluble palmitate form and in its provitamin form, Beta Carotene. While preformed A has long been known to play a role in the body’s defenses, beta carotene itself has recently been shown to possess a powerful ability to scavenge free radicals and contribute to the youthful function of some tissues. Vitamin E is one of the most important antioxidant compounds in nature. It works to prevent harmful oxidation within each cell and is vital in the protection of red blood cells from free radical-induced rupture. Selenium is an extremely powerful antioxidant shown in studies to work synergistically with Vitamins A, C, and E. In combination with cysteine, selenium helps build the glutathione peroxidase molecule. ÉLAN VITÀL offers a 50/50 blend of the two most scientifically supported forms of selenium: L-selenomethionine and sodium selenite. In addition to being an antioxidant itself, Zinc works closely with fat-soluble vitamin A by facilitating its release from the liver to the rest of the body. In ÉLAN VITÀL, Zinc is synergistically bound to methionine for optimal bioavailability. Copper sebacate is a natural compound that can function as the copper-SOD antioxidant system in the body, one of the first lines of defense against free radical attack. Copper sebacate is a highly absorbable form that possesses significant free radical scavenging activity.
Supporting Structural Integrity
An important adjunct to antioxidant nutrition is the amino sugar N-Acetyl Glucosamine, or N-A-G™. Amino sugars are essential components of cell membranes and their surface structures, as well as of the “ground substance” that holds body tissues together. They are also a key constituent of the synovial fluid in the joints. Recent research has revealed that amino sugars play an important role in maintaining the integrity of the connective and structural tissues of the body, a property that complements perfectly the actions of antioxidants: where antioxidants may prevent damage from occurring, amino sugars may help the body repair and regenerate damaged tissue. N-A-G’s activity is supported in ÉLAN VITÀL by other nutrients helpful to structural tissue. The mineral Manganese is required for building amino sugars into mucopolysaccharides, the large molecules that make up the ground substance that holds cells together. Choline and Inositol are both components of phospholipids, principal constituents in cell membranes. Two B vitamins, Folic Acid and Vitamin B12, are important to cell regeneration and to the development of healthy red blood cells.
Enhanced Energy to Maximize Metabolism
ÉLAN VITÀL is a potent source of coenzymes, metalloenzymes, and metabolites involved in energy production in the body. There are two main energy production cycles in the cells: the glycolytic cycle and the Krebs’ cycle. Together, they generate about 90-95% of the body’s entire energy supply – using fats, sugars, and amino acids as fuel, with enzymes as facilitators. The enzymes which catalyze energy production function in combination with coenzymes made from vitamins such as B1, B2, B3, B5 and Biotin, plus metalloenzymes made from minerals, including Magnesium, Manganese, and Copper. Biotin, an often overlooked nutrient, may function to help the body maintain a youthful metabolism. The mineral Magnesium aids in energy production, not only by acting as a cofactor to some enzymes, but also as a stabilizer of ATP, the body’s primary energy molecule. Some of the key connecting enzymes in the energy production process require two additional non-vitamin coenzyme nutrients to maximally convert food into energy: Lipoic Acid and Coenzyme Q10. Lipoic acid helps convert the end-product of the glycolytic cycle, pyruvate, into acetyl-CoA, a principal fuel for the higher energy Krebs’ cycle. Coenzyme Q10. is the connecting link for three of the four main enzyme complexes in the Electron Transport System, an off-shoot of the Krebs’ cycle, where ATP molecules are “cashed in” for energy. The muscle-supporting electrolyte mineral Potassium is in the form of Alpha- KETOglutarate, a critical Krebs’ cycle metabolite that has additional benefits. It has long been used to improve the efficiency of ammonia-clearance from the body, an indispensable function, as ammonia is both exceedingly harmful and constantly produced through the natural metabolism of proteins. Because alpha-KETOglutarate is an organic compound well-recognized by the cells, it is an excellent transporter of potassium into the cells. Succinic Acid, or succinate, is also a metabolite in the Krebs’ cycle. It not only boosts production of ATP energy potential, but also increases the muscle cells’ production of creatine phosphate, another high energy biochemical. Chromium is the essential mineral component of glucose tolerance factor, or GTF, which functions to help insulin (one of the two main blood sugar-controlling hormones in the body) draw sugar molecules from the bloodstream into the cells.
ÉLAN VITÀL contains natural substances that sharpen performance beyond just the physical. N-Acetyl L-Tyrosine is a highly stable and absorbable form of the conditionally essential amino acid L-tyrosine, a precursor to the major excitatory neurotransmitters dopamine, norepinephrine, and epinephrine. DMAE is a precursor to one of the body’s main neurotransmitters, acetylcholine. From the Plantioxidants comes standardized Ginkgo biloba extract, whose compounds readily cross the blood-brain barrier where they support the integrity of the capillaries in the brain.
Guarding the Liver
ÉLAN VITÀL provides several nutrients which collectively support optimal liver function. This is an essential aspect of a multiple, because the liver is responsible for converting nutrients – from food as well as from supplements – into their usable forms. If liver function is compromised in any way, nutrient supplements may be rendered inert in the body. The liver is especially at risk because it must filter out ingested toxins and is continually exposed to chemicals that generate free radicals. N-Acetyl Cysteine and Silymarin have both demonstrated a strong affinity for the liver. Nacetyl cysteine contributes to increased levels of glutathione and glutathione peroxidase, both of which the liver uses in its natural cleansing function. Silymarin provides unparalleled support to the liver’s natural regeneration process. Because of its many vital functions, the liver uses as much as 12% of the body’s energy supply, even though it represents only 3% of body weight. The liver therefore uses a greater proportion of energy nutrients, especially Coenzyme Q10 and Lipoic Acid. Both are highly concentrated in the liver; and lipoic acid in particular has been researched and used heavily in Europe where it is prized for its special protective actions in the liver. Ascorbyl Palmitate is a fat-soluble form of Vitamin C, meaning it can provide antioxidant protection for fatty tissue. This is especially valuable to the liver, which tends to develop fatty streaks that are most vulnerable to damage. Vitamin E has been researched extensively for its antioxidant properties with regard to the liver.
The Multiple for the 21st Century
ÉLAN VITÀL is truly a one-of-a-kind multinutrient supplement: one that leaves no nutritional stone unturned. Based on the biochemical principles of nutrition and metabolism – in context of today’s challenges to our health – ÉLAN VITÀL approaches optimal nutrition from several directions...all leading to a lifetime of health and vitality.
Calcium D-Glucarate and Tumors
May 27, 2005 09:40 AM
Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Walaszek Z; Hanausek-Walaszek M; Minton J P; Webb T E Carcinogenesis (1986 Sep), 7(9), 1463-6. Journal code: 8008055. ISSN:0143-3334. United States. Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 3091283 AN 86298867 MEDLINE
Using as a criterion the inhibition of serum beta-glucuronidase activity, dietary calcium D-glucarate is shown to serve as an efficient slow-release source in vivo of D-glucaro-1,4-lactone, the potent endogenous inhibitor of this enzyme. Using the 7,12-dimethylbenz[a]anthracene model of mammary tumor induction in rats it is shown for the first time that feeding the rats calcium D-glucarate-supplemented diet after treatment with the carcinogen, inhibits tumor development by over 70%. Supportive evidence is presented for the theory that calcium D-glucarate inhibits or delays the promotion phase of mammary carcinogenesis by lowering endogenous levels of estradiol(estrogen) and precursors of 17-KETOsteroids. Therefore, dietary glucarate can be used to lower blood and tissue levels of beta-glucuronidase, and in turn of those carcinogens and promoting agents which are excreted, at least in part, as glucuronide conjugates.
May 24, 2005 10:05 AM
Abstract A dietary supplement for promoting healthy hormonal balance in adult human subjects, and especially in elderly subjects, that comprises a secretagogue for stimulating the release by the pituitary, and the conversion by to Insulin-Like G, in combination with 7-KETO dehydroepiandosterone (7-KETO DHEA). The dietary supplement also includes other interacting ingredients for delivering antioxidants for retarding damage at the cellular level caused by the presence of free radicals, and natural herbs for promoting physiological health.
Other References Jamieson, J. et al., "The Role of Intermediates as an Alternative to High Injections," American College for Advancement in Medicine, (Oct. 30, 1997).
What is claimed is:
May 21, 2005 01:33 PM
KETOjuice™ Smoothies provide a creamy and delicious way to enjoy the tremendous nutritional benefits of fruits and vegetables, which help to supercharge all low-carb diets and maximize results. Each incredibly delicious serving contains only 2 grams of carbohydrates, yet provides 23 grams of non-GMO soy protein.
tasty snack in the afternoon after a hard days work. tastes best when blended with some ice.