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Benefits of Taking Magnesium: Why You Need This Amazing Mineral.
December 27, 2022 10:39 AM
Magnesium is an essential mineral that many people overlook, but it’s extremely important for the overall health of your body. According to the National Institutes of Health (NIH), more than 68% of U.S. adults don’t meet the recommended daily intake of magnesium, which is 350mgs per day. But why should you care about how much magnesium you’re consuming? Magnesium is involved in over 300 enzymatic reactions and metabolic pathways in the body, so it plays a key role in our overall health and well being. Let’s take a closer look at the importance of magnesium and why we need to get enough into our bodies every day.
How Magnesium Keeps Us Healthy
Magnesium plays an important role in everything from muscle and nerve function to energy production and blood pressure control. That means if your body doesn't have enough magnesium, you could experience a wide range of symptoms such as fatigue, insomnia, loss of appetite, nausea, depression, anxiety or even headaches. In addition to these uncomfortable symptoms, not getting enough magnesium can also lead to calcification of the cardiovascular system due to calcium deposits in artery walls—a conditionn known as arteriosclerosis—which can increase your risk for heart attack or stroke. So where can we get magnesium?
Food Sources Rich in Magnesium
Fortunately there are plenty of foods that contain high levels of magnesium including dark leafy green vegetables like spinach or kale; nuts and seeds like almonds or pumpkin seeds; legumes like kidney beans or black beans; whole grains like quinoa or brown rice; avocados; bananas; figs; yogurt; dark chocolate; and even coffee! So if you're looking for ways to increase your intake of this essential mineral without having to take supplements every day, try incorporating one (or more!) of these foods into your diet on a regular basis or take a magnesium supplement.
It's can be easy to forget about minerals like magnesium when it comes to our overall health and well-being, we have to keep in mind a well rounded diet is very important because magnesium plays an important role in keeping us healthy! Now that you know how vital this mineral is for our bodies, make sure you're getting enough each day by choosing foods that are rich in magnesium from leafy greens to nuts or by taking a dietary supplement of magnesium. Doing so will help ensure that you remain healthy now and for years to come!
The Benefits of Collagen Joint Support Powder
October 26, 2022 12:42 PM
As we age, it's not uncommon to start experiencing joint discomfort. This can make even simple everyday activities, such as walking or going up and down stairs, become painful. However, there are things you can do to help support your joints and promote joint comfort. One such product is Collagen Joint Support Powder. Let's take a closer look at what this product is and how it can help you.
What is Collagen Joint Support Powder?
Collagen Joint Support Powder is a combination of ingredients that help to support the formation and function of healthy joint tissue.* This product uses hydrolyzed collagen that has been enzymatically treated for ease of absorption, as well as MSM (methylsulfonylmethane), a biologically active form of sulfur, that serve as building blocks for collagen synthesis.* Glucosamine is included as an essential structural component that is naturally present in bones and joints.* Numerous clinical studies have demonstrated that glucosamine can help to support healthy joint structures and promote joint comfort.*
How Does It Work?
The ingredients in Collagen Joint Support Powder work together to help support the formation and function of healthy joint tissue.* Hydrolyzed collagen has been enzymatically treated for easy absorption and helps to provide the building blocks for collagen synthesis.* MSM is a biologically active form of sulfur that helps to support the structure of collagen.* Glucosamine is an essential structural component that is naturally present in bones and joints and helps to support healthy joint structures.* Clinical studies have shown that glucosamine can help to promote joint comfort.*
What Are the Benefits?
There are many benefits associated with taking Collagen Joint Support Powder. This product can help to support the formation and function of healthy joint tissue,* provide the building blocks for collagen synthesis,* support the structure of collagen,* and promote joint comfort.* Additionally, Collagen Joint Support Powder is easy to take—simply mix it into your favorite beverage once daily. It's also available in an unflavored powder if you prefer not to add it to a beverage.
If you're looking for a way to promote joint health and comfort*, consider trying Collagen Joint Support Powder. This product uses hydrolyzed collagen that has been enzymatically treated for ease of absorption, MSM (methylsulfonylmethane), and glucosamine to help support the formation and function of healthy joint tissue,* provide the building blocks for collagen synthesis,* support the structure of collagen,* and promote joint comfort.* Give Collagen Joint Support Powder a try today!
The Benefits of Beef Gelatin
September 12, 2022 12:49 PM
Did you know that beef gelatin is approximately 90% protein? This hydrolyzed form of beef gelatin has been enzymatically predigested to enhance absorption. Gelatin is a water soluble protein that is derived from collagen. It is known for its many health benefits which include joint and skin health, gut healing, and improved digestion.
Beef gelatin contains amino acids that are necessary for the maintenance of cartilage and joints. Gelatin can help to reduce inflammation and pain associated with osteoarthritis and other forms of arthritis.
Gelatin is beneficial for skin health due to its high collagen content. Collagen is essential for skin elasticity and firmness. It can also help to reduce the appearance of wrinkles and fine lines.
Gelatin promotes gut healing by restoring the mucosal lining of the digestive tract. It can also help to improve digestion and reduce inflammation.
If you are looking for a protein powder that has numerous health benefits, then beef gelatin is a great option! Gelatin provides joint and skin health, gut healing, and improved digestion. Give beef gelatin a try today and see how you feel! Your body will thank you!
Vitamin D Linked to Heart Health: Study Shows Promise in Preventing Cardiovascular Disease
April 26, 2022 10:18 AM
A recent study has shown that Vitamin D may play a role in preventing cardiovascular disease. The study, which was conducted by researchers at the University of Edinburgh, looked at data from over 10,000 adults. They found that those who had the highest levels of Vitamin D were less likely to develop heart disease or have a stroke. This is great news for those looking to improve their heart health!
What is Vitamin D and why is it important for heart health?
Vitamin D is an essential nutrient that plays various important roles in the body, including helping to maintain healthy bones and supporting immune function. In recent years, scientists have also begun to uncover the critical role that Vitamin D can play in promoting cardiovascular health. Vitamin D is involved in the regulation of several important cardiovascular processes, including blood pressure and lipid metabolism. Studies have shown that individuals with lower levels of Vitamin D are at increased risk for heart disease and stroke. Therefore, ensuring adequate vitamin D levels through diet, sun exposure, or supplementation may help to protect against heart conditions and improve overall cardiovascular health.
The study on Vitamin D and heart health
Researchers at the University of South Australia have recently conducted a study exploring the link between vitamin D and heart health. They found that individuals with higher levels of vitamin D in their blood were less likely to suffer from cardiovascular diseases, such as heart attacks, than those with lower levels. The results suggest that vitamin D plays an important role in protecting the heart and maintaining efficient cardiovascular function. This is important not only for preventing or mitigating the effects of heart disease, but also for overall health and well-being. Overall, the results of this study highlight the importance of ensuring adequate levels of vitamin D to safeguard our hearts and keep us healthy.
How to get more Vitamin D in your diet
While vitamin D-3 is essential for good health, many people struggle to get enough of this important nutrient through their diet alone. With so many factors affecting our ability to absorb nutrients from food, it can be difficult to maintain healthy levels of vitamin D through regular meals. However, research suggests that we may be able to get enough of this vital nutrient by taking supplements or getting outside on sunny days. For example, studies show that simply spending time in sunlight for a few minutes each day can go a long way toward maintaining adequate vitamin D levels in the body. Additionally, many foods are fortified with vitamin D-3, including dairy products and some types of bread and cereal. Ultimately, the best way to ensure adequate vitamin D-3 levels is through a combination of dietary sources and appropriate supplementation. So don't be afraid to take that extra step or buying a supplement – your health will thank you!
Bottom line: Vitamin D is a promising nutrient for heart health
Vitamin D-3 is a nutrient that is continually been getting attention for its potential benefits to heart health. This nutrient can be obtained through certain foods, such as oily fish and eggs, but many individuals also supplement with vitamin D-3 on a regular basis. Preliminary research suggests that this nutrient may help to lower cholesterol levels and reduce inflammation in the arteries, two important contributors to cardiovascular disease. Additionally, studies have shown that vitamin D-3 can help to strengthen the immune system, which further enhances overall heart health by keeping the body healthy and strong. Overall, when it comes to promoting heart health, vitamin D-3 seems like a promising nutrient that deserves further scientific study and exploration.
Assist Mineral absorption
Vitamin D is an important nutrient that helps the body absorb calcium and phosphorus. It also plays a role in maintaining strong bones and muscles. Unfortunately, foods are a relatively poor source of vitamin D. The best way to get this nutrient is through exposure to sunlight. However, too much sun exposure can lead to skin damage, so many people choose to take a supplement instead. Vitamin D supplements are available in both liquid and pill form. They are typically taken once a day, and they can help people maintain adequate levels of vitamin D without exposing themselves to the harmful effects of the sun.
Vitamin D-3 is involved in over 300 enzymatic processes in the body
As we already know, vitamin D is a fat-soluble vitamin that plays an important role in bone health and calcium absorption. Vitamin D-3, the form of vitamin D found in supplements, is involved in over 300 enzymatic processes in the body. These processes include cell proliferation, immunomodulation, and regulation of gene expression. Vitamin D-3 has also been shown to have anti-inflammatory and neuroprotective effects. Supplementation with vitamin D-3 has been shown to improve bone density and reduce the risk of fractures, particularly in older adults. In addition, vitamin D-3 supplementation has been shown to improve muscular strength and reduce the risk of falls in older adults. While most people can get adequate amounts of vitamin D from exposure to sunlight, those who don't get enough sun exposure or have dark skin are at risk for vitamin D deficiency. Supplementation with vitamin D-3 is an effective way to ensure adequate intake of this important nutrient.
The importance of magnesium in the prevention and treatment of Type2 diabetes
November 23, 2018 02:19 PM
Type 2 diabetes is something that is really common in the world today. There seems to be so many people who are struggling from it. Doctors have found ways to deal with it and the people who have it always have to go through a process to maintain healthy sugar levels. However, the emergence of magnesium as a potential factor in the prevention and treatment of the disease is promising. By incorporating more magnesium into one's diet, it can make a big difference.
"New research published in the Journal of the American Medical Association has shown that achieving ideal magnesium intake can help prevent type 2 diabetes, as well as improve blood glucose levels in people who’ve already been diagnosed with the condition."
Read more: https://www.naturalnews.com/2018-11-13-magnesium-prevention-and-treatment-of-type-2-diabetes.html
Magnesium and Your Kids Health
Did you know that magnesium is essential for the health and development of growing girls and boys? Unfortunately, most American children are borderline deficient in magnesium.
Magnesium is required in over 300 enzymatic processes in the body, children need it for health bones and teeth. This mineral is essential for muscular relaxation, as well as proper nervous system function. Magnesium is a relaxing mineral and can help your child fall a sleep faster and keep him or her asleep longer.
Your Kids will lover the great taste of Magnesium Kidz by Natures Plus. see below:
What Does Iron Do For The Body
May 03, 2014 05:33 AM
Heath benefits of iron to the body
Iron is a naturally occurring mineral found in numerous nutritious foods. Usually, our body requires it for a variety of functions such as proper growth and development. It hardly exist in the body system as free ionic and all of it present is either in the iron storage proteins or the hemoglobin, hence the need for the body to acquire from an external source, that is, food or otherwise serious health problems and complications may result. Food varieties such as meat, fish, poultry, fruits and vegetables contain iron capable of maintaining its optimum level in the body system.
Health benefits of iron are numerous, they include-
A) Muscle function.
B) Hemoglobin formation.
C) Iron deficiency anemia.
D) Brain function.
E) Strengthening immunity.
F) Body temperature regulation.
Why Zinc is Important for the Body
December 21, 2013 01:39 AM
Zinc is an important trace mineral found in our bodies. Its importance cannot be underestimated for its lack would cause vital body functions to come to a stop.The amount of zinc found in our bodies is about 3 to 4 grams. Zinc is also known to help people escape dangerous diseases like acne, Alzheimer's and many others. Below is a brief account of the various vital functions of zinc:
Zinc enables vital body functions to occur.This is because it stimulates over a 100 enzymes in the body. Enzymes are known to aid in body processes including such activities as making vital body components or helping break down chemicals that the body does not need or would rather harm it, if left to accumulate. Still in enzymatic functions, zinc plays a role in the formation of DNA, bones and breakdown of the proteins we eat.
Zinc is very vital when it comes to protecting our bodies against infections. It achieves this function in a multiplicity of ways, the very first being the pivotal role it plays in the healing of wounds. Zinc is also found in body secretions that kill bacteria and viruses which may find their way into our bodies. This is made possible by the fact that it has anti-microbial effects.
Zinc is also known to assist in protecting our cell membranes from the harmful effects of metals such as copper and iron. Another similar function of zinc is its ability to assist the liver form an antioxidant known as super-peroxide that assists in elimination of harmful toxins that would otherwise harm the body. Zinc will also help reduce poor night vision for it will slow ocular degeneration.
Benefits of Calcium and Magnesium
December 27, 2012 01:51 PM
Two important nutrients that are common deficiencies in the diet are calcium and magnesium. Calcium is an important mineral for bone density, blood clotting, muscle contractions, and many other smaller mechanisms essential for human life. Magnesium has similar actions to calcium in the body. It is also found in the bones and is important also for protein synthesis and as a co-factor in the body's essential enzymatic reactions. These two nutrients work together and are commonly seen combined in multivitamins and other supplements.
Calcium and magnesium are important nutrients for every person, but especially for women and children who are still growing. Maintaining an adequate intake of these two nutrients can be challenging, especially if a person is lactose intolerant. This is why many people turn to dietary supplements. It's fairly common to see calcium and magnesium in the same supplement and for anyone who is concerned about their dietary intake, supplements can be a good idea.
While these two nutrients are essential for bone density and overall health, many people who take supplements may not be taking the right kind. Some types of magnesium and calcium supplements cannot be absorbed by the body and will instead pass through the digestive system without entering the bloodstream.
Most health professionals recommend calcium and magnesium asporotates. This is a unique mixture of calcium and magnesium with aspartic and citric acid as well as a whey protein concentrate that contains orotic acid. The acids in the supplement work to break down the calcium and magnesium partially, contributing to a higher digestion and absorption rate in the body.
These are some of the health benefits of these two nutrients and why it is so important to maintain adequate stores of them in the body. If taking a supplement, be sure to take calcium and magnesium asporotates in order to absorb these nutrients.
Support the Adrenal Glands with Natural Vitamins and Feel the Difference
October 05, 2011 03:50 PM
Your Adrenal Glands, Energy Levels, And How You feel
Our body is a very complex system that needs to be well taken care of through adequate intake of essential vitamins and minerals. Living healthy and right will allow you to reap and experience a better and more comfortable life in the future.
The adrenal glands are one of the most important glands in the body. It can be found on top of your kidneys; however, these two glands that you have in your body are actually different from one another. The center of the gland also known as the adrenaline manufactures epinephrine and is governed by the autonomic nervous system. These vital glands perform special functions that are very essential for life and health. Any alteration in condition would surely have corresponding effects in the body.
For us to keep our adrenal glands healthy, it is very necessary to consume foods that are rich with the following:
B vitamins can help restore the adrenal glands when they are over worked from the stresses of life.
It is inevitable that vitamin C is one of the most useful vitamins for the body because of its capacity to strengthen the immune system hence, keeping you away from the threats of diseases and body disequilibrium. To be more specific, vitamin C is very crucial for adrenal function. The highest concentrations of vitamin C can be found in the brain tissues and in the adrenal glands because the secretion of the vitamin is at its peak during stress. To help your immune function, it is advisable that you will take 500 to 1000 mg of the said vitamin per day.
For optimal adrenal function, it is advisable to take about 100 to 150 mg of pantothenic acid daily because this vitamin B is noted to support and enhance adrenal function as well as correct adrenal deficiency.
Has the innate capacity to prevent adrenal hormones breakdown therefore maintaining optimal levels. Another vital function of licorice is its power to cure indigestion.
If you want to lessen the discomforts that you will feel during low blood sugar episodes, it is advisable for you to consume and take natural remedies and supplementation that are rich with chromium. The Adrenal Stress End has enough chromium content which is highly beneficial for the success of an enzymatic therapy. Experts would recommend taking one to two capsules per day for you to grasp its full effects.
To sum up everything, it is very important to take and engage in measures that could help us achieve optimum level of wellness because if not we will surely suffer from the consequences of being sick brought about by a disequilibrium in the body. Since we all know how important our adrenal glands are and the distinct function that it do for the body, we should do our very best to keep it healthy and well functioning. Vitamin C, licorice, Pantothenic acid, and chromium are just few of the important elements that you should provide your adrenal glands. Taking these would make you feel better and secured.
What Supplements Are Useful In Combating Blood Clots?
October 04, 2011 03:14 PM
Vitamins And Your Health
As we know for a fact, one of the properties of blood is its ability to coagulate in order to stop bleeding. This coagulated blood is commonly known as a clot. Blood clot is important to the body to prevent excessive bleeding and serves as a vital part in the process of inflammation and wound healing. However, if a clot occurs abnormally it can cause significant danger to the body. A blood clot can cause obstruction in the circulation and may result to life - threatening health conditions such as heart attacks, cerebrovascular accident or strokes and pulmonary embolism. It can also cause poor tissue oxygenation and perfusion which can damage the affected cells and might cause disability or inability to function of certain organs or body part.
There are many traditional modalities in preventing and treating abnormal blood clot formation. One of the most commonly used is the medication called Aspirin in low – dosage. This conventional drug is popularly prescribed by doctors to decrease the clotting property of the blood. However, in emergency cases, a surgical procedure may be deemed important to remove the blood clot which significantly interrupts proper blood circulation.
Aside from medications, there are many supplements that have the capacity to decrease the risk of abnormal blood clotting. These include supplements high in:
1. FISH OILS. Fish oils are rich in omega-3 fatty acid which has the capacity to thin the blood. Therefore, if the blood is not viscous, the pressure inside the blood vessel is lesser as well. A high blood pressure can cause damage to the walls of the blood vessels, thus activating blood clot formation. Also, a non – viscous blood can also better circulate into smaller blood vessels than that of a viscous blood, therefore, enhancing tissue oxygenation. Clinical studies also revealed that omega – 3 fatty acids can effectively decrease Thromboxane A which is one of the clotting factors found among platelets.
2. CHAMOMILE. This herb has an anti – platelet property. It has a mild to moderate effect in regulating clot formation.
3. GINGER. Ginger has many health benefits. One of its promising benefits is its mild anti – platelet property and its ability to dissolve fibrin. This herb is widely used as a supplement to enhance blood circulation all over the body.
4. CATECHIN AND QUERCETIN. These chemical compounds are classified as antioxidants. They can effectively reduce the adhesion property of platelets.
5. CURCUMIN. This chemical comes from the spice called turmeric. This is considered to be an anti – thrombotic, as well as a potent anti – inflammatory agent.
6. DEHYDROEPIANDROSTERONE (DHEA). This substance is primarily an anti – aging agent. However, studies reveal that it can significantly reduce the process of inflammation by preventing the substance that can generate inflammation within the veins, arteries and capillaries called Cytokines. With decreased production of cytokines, it will result to lesser coagulation and clumping of platelets and reduced movement of bad cholesterol or Low Density Lipoprotein (LDL) into the walls of the blood vessels, thus decreasing the chance of clot formation and atherosclerosis.
7. VITAMINS C AND E. These vitamins are important for preventing abnormal collagen – induced platelet activation by inhibiting the production of hydrogen peroxide. Vitamins C and E are also important in many enzymatic actions that regulate blood cholesterol levels.
Is Cod Liver Oil Good for My Health?
July 30, 2011 01:19 PM
Cod liver oil is a dietary supplement obtained from the liver of a group of fishes collectively known as cod. It is an all natural remedy for a diverse variety of disorders, and as such remains one of the most popular supplements to this day. Recent studies have confirmed many of its age-old health claims. It is now common knowledge that it aids joint health, treats skin conditions, and improves brain function.
Deactivates Pain Chemicals
The nutrient profile of cod liver oil makes it an excellent source of eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. These omega 3 fatty acids have long been identified by scientists as anti-inflammatory compounds. Numerous studies have documented that they exert an inhibitory effect on chemicals that sensitize tissues to pain, cause excessive inflammation, and bring on rheumatism.
Nourishes Joint Cartilage
Cod liver oil is a traditional treatment for joint pain characteristic of arthritis. In recent years, it has been noted as the leading therapeutic remedy for rheumatoid arthritis and osteoarthritis. Research has shown that it is capable of switching off enzymatic processes responsible for the destruction of cartilage tissue in arthritis. Also, its fatty acid content nourishes the proteins found in joint cartilage.
Protects Nervous Tissue
The myelin sheaths that insulate the axons of nerve cells located in the brain and spinal cord require fatty acids to support their physiological functions. In particular, DHA is the principal fatty acid that nourishes nervous tissue. Cod liver oil has been utilized as an adjunct medication for multiple sclerosis in studies, and reports suggest its potential as a mainstay of treatment for other neurological disorders.
Enhances Brain Function
In addition to their known role in the upkeep of myelin sheaths, fatty acids are directly involved in the development of brain function. In fact, they are a major component of breast milk. For years, nutrition experts have suggested consumptions of cod liver oil to combat neurodegenerative disorders as well as enhance cognitive capacities as it contains high levels of compounds proven as effective nootropics.
Alleviates Skin Conditions
The nutrient profile of cod liver oil is particularly good for the skin. Apart from the fact that it counters inflammatory agents that cause hypersensitive skin conditions, such as eczema and psoriasis, it also promotes tensile strength and maintains skin elasticity. Cod liver oil is a good source of omega 3 fatty acids, essential fatty acids, vitamin A, vitamin, D, and vitamin E, all of which contribute to skin health.
Prevents Heart Disease
Cod liver oil maintains heart health and even reverses cardiovascular disorders. Medical professionals have supported this nutritional supplement as it has been clinically proven to cut the risk of heart disease. It alters the profile of lipids present in the blood and appears to reduce cholesterol. For decades, lower incidence of cardiovascular disorders has been tied to populations that consume high amounts of cod.
How Important are Minerals in the Body
May 07, 2011 11:33 AM
Minerals And Your Health.
Minerals are nutrients necessary for human life. They are often found in the foods we eat at dietary quantities. Living a healthy lifestyle always means having the right amounts of minerals in our diet. Each mineral has a daily value, which necessitates its consumption on a regular basis. Not meeting the requirement for a single mineral for extended periods of time will lead to deficiency.
Deficiency in any nutrient will always impact our health. Minerals are especially important because they are very pervasive throughout the human body. They even affect the digestion and absorption of other nutrients. It is common knowledge that long-term deficiency in any mineral will have deleterious effects on human health that may even result in malnutrition and faster progression of diseases.
Dietary minerals are actually chemical elements that are involved in countless chemical reactions in the human body. It is very probable that various tissues and organs will collapse when these elements progressively decrease. Some elements are necessitated in relatively large amounts, and this group of minerals is called quantity elements, which include potassium, chlorine, sodium, calcium, phosphorus, sulfur, and magnesium. Human health is quite sensitive to low levels of these minerals.
Potassium is an electrolyte present in systemic circulation to regulate blood pH. Chlorine is generally obtained from table salt, which is indispensable in the synthesis of gastric acid. Sodium, like potassium, is a systemic electrolyte that also participates in many cellular functions. Calcium is required by almost all tissues, and absolutely necessary for bone health. Phosphorus is involved in the upkeep of several tissues, including bones. Magnesium plays a pivotal role in the metabolism of energy.
Trace minerals refer to dietary elements that are needed in, as the name suggests, minute quantities. A significant fraction of the global population has been reported to be deficient in most of these elements in that their intake has been associated with foods that are not consumed on a daily basis. In the past few decades supplementation seems to be the only certain way to obtain healthy levels of trace elements, which include zinc, iron, manganese, copper, iodine, selenium, and molybdenum.
Zinc is necessitated by over a hundred proteins that belong to all classes of enzymes. Iron prevents iron deficiency anemia since it is central to the production of hemoglobin. Manganese binds to proteins and activates their biological roles in enzymatic reactions. Copper and molybdenum participate in the metabolism of oxygen, which occurs in every cell of the body. Iodine is pivotal to the biosynthesis of thyroid hormones, influencing physical growth, mental development, and metabolic rate. Selenium boosts the immune system and improves the antioxidant defense of cells.
The scientific community has estimated the recommended daily allowance for each dietary mineral for good reason. Regular intake of minerals helps ward off diseases and keeps our body in prime condition.
Minerals are essential for life, are you getting enough of them daily?
How Does Zinc Boost the Immune System and What Else Does this Mineral Do
May 02, 2011 01:58 PM
Zinc And Good Health!
Zinc is considered a transition metal in general, and as such one of the most abundant transition metals in living organisms, including human beings. It plays a central role in the molecular structure of proteins, which is indispensable in catalytic activities of over a hundred enzymes. These proteins belong to all enzyme classes and have far-reaching effects on the human body, notably in the immune system.
In the past few decades, the scientific community has unearthed countless chemical reactions that take place inside the human body. A number of these reactions necessitate the presence of zinc. While zinc is considered toxic in high amounts, it is classified as an essential trace mineral, which means it has a daily value. A deficiency in zinc has serious effects on growth and development as implicated in the life cycle of cells.
Stabilizes Cellular Structures
Zinc is a trace mineral that is quite pervasive at the cellular level as all cells have zinc demands. This dietary element keeps cells in prime condition and maintains the health of cell organelles. For one, zinc is required to stabilize ions that functions as interaction modules responsible for binding DNA, RNA, and other particles found within cells. The absence of zinc in cells will cripple these activities.
The complete absence of this trace mineral is improbable, but low levels of elemental zinc in the body have been observed to have serious effects on cellular health. The capacity of cells to contain radical damage depends on the availability of zinc. Depleting levels of zinc result in an impaired antioxidant defense and greater susceptibility to free radicals and other reactive oxygen species.
Induces Enzymatic Reactions
Enzymes are proteins that play functional roles in the metabolism of bioactive compounds. They are categorized into many classes, depending on their catalytic functions. These functions are vital as they are one of the mechanisms in the employ of the body to sustain homeostasis. Some classes are involved in immune responses in the prevention of disease and the alleviation of chronic disorders.
All classes of enzymes are affected by the metabolism of zinc one way or another, with over a hundred requiring the direct involvement of zinc to induce catalysis. Zinc is of special note in a chemical reaction called hydroxylation, a process that helps cleanse the body of toxins. With hydroxylation, zinc participates in the conversion of lipid-soluble substrates into water-soluble products ready for excretion.
Modulates Immune Responses
The human body utilizes zinc in many different metabolic pathways that influence the processes needed for prompt immune responses. In the case of common infections such as colds and flu, zinc curtails severity of symptoms and raises immune responses to optimum levels. More importantly, healthy levels of zinc enable the body to take on preventative measures against diseases.
Remember even though zinc is an important mineral, to much can cause problems as well. Do not exceed 150mgs daily for extended periods of time to maintain safe levels of zinc. I suggest 15mg to 75mg daily.
Did You Know without Magnesium, You Could not Survive?
February 16, 2011 02:04 PM
Magnesium and your Health
Magnesium is vital to life on all levels. All types of cells in all organisms must maintain a balance of magnesium to support life as we know it, and its presence in human beings is ubiquitous at a cellular level. Low levels of magnesium have been tied to a number of medical conditions such as asthma, diabetes, and osteoporosis whereas excesses are known to impair functions of tissues and organs, notably nerves cells and the kidneys.
Supplies the Human Body with Energy
Glucose is best known as the primary source of energy of most multicellular organisms, including of course human beings, while adenosine triphosphate, or ATP, is the form of energy yielded by the utilization of glucose within the cells. All forms of carbohydrates and fats from our diet must be broken down into simpler compounds to be able to be converted into ATP that powers cellular activities.
That being said, ATP requires magnesium in its participation in a number of physiological functions. What we refer to as ATP in fact contains ions of magnesium, for the former must be chemically bound to the latter to perform its role in interactions with protein kinases. In fact, it is a common observation that magnesium almost always acts as the functional regulator in the binding of proteins with ATP.
Participates in Enzymatic Reactions
More or less 300 hundred enzymes in the body are dependent on ATP, which we refer to as coenzyme, a kind of chemical compound that binds to protein. Magnesium acts as glue that keeps the enzymes and ATP together, aiding in the catalytic activities brought about by the enzymes and their utilization of ATP. Thus, the metabolic pathways that employ these enzymes rely on the presence of magnesium.
One example of the interaction of ATP with proteins that necessitate magnesium as a divalent cation, in other words functional regulator, is in enzymes that modify the molecular structure of other proteins. These enzymes are transcribed in more than 500 protein genes and affect up to 30 per cent of all proteins in the human body. Moreover, magnesium plays a role in ribosome, the cellular component responsible for creation of RNA copies and the manufacture of proteins.
Magnesium Facilitates Absorption of Calcium
Over 60 per cent of magnesium in the body is stored in the bones, and this fact has become the basis of the recent trend of dietary supplements that utilize magnesium to induce healthy bone density. Indeed low levels of magnesium has been reported to contribute to the degeneration of bones as we age, resulting in porous bone particles in a medical condition called osteoporosis.
Prevents Ailments of the Circulatory System
Since magnesium is essentially everywhere in the body, it significantly impacts the overall health of the circulatory system, notably in the prevention of heart diseases. Not surprisingly, insufficient levels of magnesium have been documented to cause cardiovascular problems, including hypertension and congestive heart failure, and supplementation of magnesium has been noted to cut complications of preexisting circulatory conditions.
Have you had your magnesium today?
Support Good Stomach Health and More With DGL Licorice
August 14, 2010 10:48 AM
What is DGL Licorice
We all know what licorice is - the root of the licorice plant, or Glycyrrhiza glabra - but what is DGL licorice? In fact it is licorice with a substance known as glycyrrhizin removed. This substance is dangerous to your health because it can cause hypertension and also reduce potassium levels. By removing this, those suffering high blood pressure can also take advantage of its health benefits. So what are these benefits?
They are not wide-ranging, but they are very important to you if you suffer any of a range of gastric problems, such as ulcers and gastritis. It can also be used to treat irritable bowel syndrome (IBS), leaky gut syndrome, and Crohn's disease, and can also be used in autoimmune conditions such as rheumatoid arthritis and lupus. If you suffer any of these conditions it worth trying DGL licorice, but let your physician know what you are doing. DGL Licorice is available in chewable form to enhance the benefits to the stomach. Enzymatic Therapy DGL Licorice is Glycyrrhizin free so you can rest assured that this product is 100% beneficial with zero side effects. Give DGL a try today!
Give DGL Licorice a try and see how it can help you!
Myth: Hydrolysis is bad for you.
April 08, 2010 04:05 PM
Agave contains Fructans or Inulin, not starch. Fructans are a naturally occurring polysaccharide or complex sugar consisting of Fructose and Glucose. Certain plants produce Fructans which is a form of energy storage. Most plants that synthesize/store Fructans do not store other material such as starch.
Enzymatic hydrolysis (one of two processes of deriving agave nectar) uses a Non-GMO enzyme to separate the complex sugars found in Fructans. No refinement beyond the evaporation of water is involved.
Hydrolysis in its simplest form is the separation of molecules. Everyday our body naturally performs simple hydrolysis in the conversion of energy for our daily tasks. In the process of Agave Nectar we are taking a complex molecule such as Fructan and separating it into natural molecules your body can absorb called Fructose and Glucose. This is the same exact process of how bees make honey. The nectar is hydrolyzed by an enzyme in the bee’s stomach and then they fan their wings to evaporate the natural water before capping the comb.
Myth: Agave Nectar uses Genetically Modified Organisms (GMO) enzymes much the same as High
April 08, 2010 04:05 PM
Enzymatic hydrolysis (one of two processes of deriving agave nectar) uses a Non-GMO enzyme to separate the complex sugars found in Fructans. No refinement beyond the evaporation of water is involved.
Avage Nectar Facts
April 08, 2010 04:02 PM
First of all let me preface by saying thank you very much for contacting Madhava Honey with your concern. Madhava has been in business for over 36 years and one of our four fundamental core values is and always will be to provide the Highest Quality product that exceeds the industry standard. Our other three core values are providing a product with the highest respect to the environment and health of the consumer, supporting community development via living wages and sustainable development of local economies, and finally providing a fair guaranteed price for our suppliers. Thirty six years ago Madhava was founded on "sustainable" practices and we take negative misleading attacks on our products very seriously. Madhava will try to respond to all the issues in question along with providing a little bit of background information on the source of the attacks. Finally at Madhava we believe in full transparency and please do not hesitate to contact us directly if you feel any questions or concerns have not been addressed. Thank you very much.
A. What constitutes Madhava's Agave Nectar?
There are 3 main components of our Agave Nectar. It is naturally composed primarily of the simple sugars fructose, glucose (dextrose), and water. Madhava’s Agave is Certified Organic and is Genetically Modified Organism (GMO) Free.
B. How is Madhava's Agave Nectar produced?
The Agave plant is truly a remarkable plant! It grows in the harshest environments with little water and no upkeep is needed. It is naturally found in Western Mexico making it a non-evasive plant to the area regarding its growth and harvest. It requires no pesticides or fertilizers and is actually a cornerstone to its ecosystem. The Agave plant is truly a sustainably grown/harvested crop.
The Agave plant is grown for 6-8 years, then before turning to seed, it is then harvested by hand. Jimadores or Agave harvesters go to the selected fields and remove the "Pina" or heart of the Agave plant, by cutting off the long spiny "leaves" and unearthing it from the soil. It is all done by hand thus reducing the carbon footprint during harvesting. The Pinas are then loaded to a truck which takes them back to the harvesting facility.
There are two methods of making the Agave Nectar from the juice of the plant. One uses a natural non-GMO enzyme and the second uses thermal hydrolysis. Both processes achieve the same goal; which is to separate the naturally occurring Fructans, which are complex sugar molecules into their simple sugar components fructose and glucose.
The actual process of hydrolysis of agave, either thermal or enzymatic, is unlike the process of High Fructose Corn Syrup (HFCS), which creates fructose out of the glucose made from the milled starch of corn. Agave Nectar simply separates Fructans or Inulin, a complex naturally occurring sugar, into Fructose and Glucose.
C. Moderation vs. Overconsumption
It is certainly true that overconsumption of any one or a combination of sugars can have detrimental effects, but this is not in a vacuum, it involves lifestyles, other food choices and other conditions. Overconsumption of any food or beverage will have ramifications. Sweeteners are ingredients which are added to foods in relatively small quantity to make them more palatable. In others, sugars can make up a large portion of the caloric value. These foods are easy to identify and avoid as necessary. People do not consume sweeteners as a solitary food in mass quantity. They are just part of the choices people make and consumption can be controlled, each of us chooses what we eat and how much. There are no health issues with moderate consumption of sweeteners; every negative circulating is relative to the overall consumption of one's diet.
Digestive Essentail Enzymes
January 04, 2009 10:29 AM
Years of researching various health-promoting herbs, vitamins, minerals, and other dietary supplements has led to the conclusion that enzyme therapy is one of the most valuable ways to maintain and promote good health. Not very many of us actually understand the enormous role that enzymes play in health maintenance, with many of us actually being enzyme depleted due to the over-consumption of cooked enzyme-less foods and the under-consumption of raw whole foods. The human digestive system was designed for a diet that is full of raw plants and fruits, but many foods today are processed, refined, heated, and fragmented.
By eating foods that have lost their own natural enzymes, the pancreas and other organs that supply digestive enzymes are over-worked. This results in enzymatic function in other areas of the body to become compromised, which leads to disastrous health implications. Replenishing enzymes through diet and supplementation is an easy way to make up for the typical diet that is full of mostly dead foods.
The human digestive system is one of the most perfectly designed systems in the body, typically functioning without problems. This means that if we are eating the right foods in the right way, then we should not have to rely on antacids, H2 antagonists, proton-pump inhibitors, and laxatives. Burping, belching, and bloating, no matter how often they occur, are actually not normal. It is ironic that the human body has a system that is far more impressive than any other machine built by humans, but we suffer from breakdowns all the time such as abdominal cramps after eating, inordinate amounts of gas, sluggish colons, and an overall lousy feeling after eating.
Statistics prove that we are not eating the right foods, and even if we were, many of us are not properly absorbing all of their nutrients because we consume huge amounts of sugar, drugs, caffeine, alcohol, and highly processed refined foods that prevent normal digestive processes. Being under constant stress and eating on the run, along with our unhealthy food choices, creates an environment inside our body that causes common cases of heartburn and indigestion, possibly leading to ulcers and colon disease.
Enzymes are protein molecules that are responsible for thousands of physiological reactions that take place in the human body. They initiate and control almost every biochemical process that occurs in the body, with nearly three thousand individual enzymes being identified to date. Enzymes help our body to digest food, repair tissue, and eliminate dangerous toxins. Digestive enzymes break down food particles, which allows them to pass through the intestinal wall and enter the bloodstream. The enzymes that are found in the blood transform nutrient particles into tissue that is found in muscles, nerves, organs, and glands.
Enzymes also contribute to the process that stores sugar in the liver and muscle tissue and preserves fatty tissue. Additionally, digestive enzymes are part of the chemical reaction that creates urea. Some enzymes even help to detoxify our blood and tissue by allowing our immune system to attack foreign material. Lastly, metabolic enzymes help create energy in our body on a cellular level by converting foot to energy, which then fuels nearly every mechanism in the body. Do you get enough enzymes on a daily basis?
Flax Seed Oil
August 07, 2008 01:53 PM
Flax seed naturally contains a variety of different categories of essential fatty acids, which includes alpha linoleic acid, linoleic acid, and omega-9 oleic acid. A lot of flax seed’s benefits are a function of its content of alpha linoleic acid, which is converted in the body to a longer chain of omega-3 EPA. Research has proven that supplementation with flax seed oil can help to increase the EPA concentrations in many tissues of the body. One of the main areas of research has been inflammation.
Many factors contribute to inflammatory reactions, including omega-6 linoleic acid, which can be converted into pro-inflammatory substances. Flax alpha linoleic acid can convert into EPA, which has the ability to convert into a prostaglandin that has anti-inflammatory properties. In inflammatory states, alpha linoleic acid and EPA compete with linoleic acid for enzymatic metabolism, resulting in a decreased production of pro-inflammatory substances. Many studies have found that the use of flax seed oil in domestic food preparation can reduce the production of inflammatory cytokines.
These studies have also shown the ability of omega-3 rich fish oils to inhibit inflammatory mechanisms in the autoimmune disease lupus nephritis, which lead to the investigation into flax having any abilities in this area. One trial found that 30g/d of flax seed was optimal for improving kidney function, decreasing inflammation, and reducing atherosclerotic development. Flax also contains antioxidants, which may be helpful to those who have SLE.
Research has also been conducted to investigate the hormonal modulating effects of ingesting lignans, which are antioxidant and phyto-estrogenic compounds that are found in flax seed. Clinical evidence indicates that phytoestrogens have an anti-cancer effect on the breast. Experimental studies in animals and humans have also demonstrated flax’s anti-cancer effects, with a 1998 review indicating that the consumption of flax may be used as a secondary prevention method against breast cancer. Flax seed has also been shown to promote prostate health, as it plays a key role in the treatment of an enlarged prostate.
The cardiovascular system is also another area of research focus for flax seed. One study showed that three months of flax seed supplementation resulted in LDL cholesterol levels dropping significantly, while HDL cholesterol did not change. Other research has shown serum lipid level reduction, but a large amount of flax seed was required to be consumed to get the same lipid-lowering effects as fish oils. Flax lignans also possess anti-platelet activating factor activity and antioxidant activity. Animal research has shown that flax seed reduced the development of aortic atherosclerosis’ by 46 percent and suppressed oxygen-free radicals.
The research concluded that dietary flax seed supplementation could prevent hypercholesterolemia-related heart attack and strokes. Lastly, the elasticity of arteries is an important factor of circulatory function, which decreases as the cardiovascular risk increases. Research has proven that obese people consuming a diet high in ALA from flax seed oil experience a marked rise in arterial elasticity, which reflects a rapid improvement in the arterial circulation.
Although flax seed offers many potential benefits, ingesting the right form of supplemental flax is crucial to gaining these benefits. Flax oil supplements are a good source of EFAs, but they do not provide great amounts of lignans. On the other hand, whole or ground flax seed is effective, but is not especially palatable. The best option of flax seed is the liquid in capsule form, as it delivers both EFAs and lignans. The nutritional value and certain beneficial results can be gained by consuming about 3,000 mg daily.
Red Yeast Rice
August 04, 2008 04:07 PM
Many natural substances that are capable of lowering blood fats and cholesterol levels that are potentially harmful have emerged. No one is suggesting that there is a magic pill that will promote healthy cholesterol levels, but nature has provided us with some specific compounds that are capable of enhancing both dietary and lifestyle changes in order to improve cardiovascular health. One of the most impressive of these compounds is that of red yeast rice, which is a fermented food substance that has been traditionally used for its red-coloring abilities in meats and other foods. Additionally, red yeast rice offers some extremely beneficial therapeutic effects, as it is the source of certain compounds that can successfully reduce cholesterol.
Pharmaceutical companies have been making cholesterol lowering drugs for many years, but natural supplements are now available which offer the consumer a way to lower cholesterol in natural way. This is extremely good news for those people who are suffering from moderately elevated cholesterol levels and is looking to avoid synthetic drug preparations and the side effects that follow.
Most of us are now aware that high serum cholesterol level is what predisposes us to cardiovascular disease along with other degenerative conditions. Learning how to control our cholesterol levels, especially the LDL and blood triglyceride levels, while keeping HDL cholesterol at desirable levels can be an extremely frustrating task. By decreasing our consumption of animal fats and certain types of oils, eating more fiber and taking prescription drugs or natural alternatives, we can easily accomplish our goal.
Dietary changes should be targeted first, but turning to cholesterol-lowering prescription drugs has both its pros and cons. Pharmaceutical preparations come with considerable side effects. Some of the drugs that are most effective contain enzymatic inhibitors that prevent the synthesis of cholesterol. Red yeast rice accomplishes the same enzyme inhibition but is considered a natural alternative that safely promotes healthy serum cholesterol levels.
Coronary heart disease refers to the damage that is done to the heart when the coronary arteries become blocked or narrowed because of a buildup of plaque or oxidized cholesterol. When cholesterol buildup breaks off and lodges in the heart or brain, this causes a heart attack or stroke. An extremely common disorder of developed nations, coronary heart disease causes more deaths in the US than any other disease. Many people who die from heart disease are ironically in otherwise good health.
High blood pressure, which is a related disorder, is similar in the fact that both can be a silent killer. The symptoms of coronary heart disease include impotence, heart attack, or stroke. Although the mortality rates from coronary heart disease have declined over the last twenty years, the reason for this decline is shown to be the better medical technology that is available. Claiming more than one million deaths every year, coronary heart disease is still a major issue facing the American society.
In order to help us prevent heart disease, we have been given many dietary guidelines. However, many of us are not motivated enough to make the dietary changes that could literally save our lives. The major causes of coronary heart disease include obesity, smoking, alcohol, high protein and high saturated fat diet, lack of exercise, high blood pressure, high cholesterol levels, and a genetic predisposition.
May 13, 2008 04:52 PM
Vectomega uses a patented biological innovation that extracts naturally occurring marine phospholipids with the omega-3 fatty acids, EPA and DHA. Very high yields of marine oil extraction are obtained from a proprietary enzymatic process of proteinaceous tissues found in the salmon heads. This enzymatic reaction is carried out in less than an hour in an inert atmosphere at a temperature lower than 60°C. The full amount of oil can be extracted using this patented process while keeping the marine oil’s natural proportions and composition. This patented innovation, called vectorization, uses a gentle, cold water and enzyme process, avoiding heat, solvents, and chemical modifications that are utilized to process other fish oils. This is a very advanced and "green" technology that delivers a great natural representation.
Fight Stress With Magnesium Supplements
April 17, 2008 04:16 PM
When stress hormones are released into the body due to a stressful situation, several things may happen. Your metabolic rate can increase, heart rate jumps, blood vessels contract and get tighter, the rate at which one breaths gets more frequent and shorter, muscles contract in response to stress among other things.
At the cellular level a significant inflow of calcium decrease cellular magnesium to calcium ratios which stimulates cellular function such as secrete fluids, contract, go into active mode. The muscles prepare to contract this includes the lungs, heart, and blood vessels. Nerves start to fire more frequent, the blood gets ready to clot, and secondary stress hormones are released. Normally when the stress crisis is over, magnesium moves back into the cells at the cellular level forcing calcium out relaxing the cells, this allows the body to slow down and relax, the nerves calm down and blood flow slows.
Magnesium plays a vital role to relax the body, once the stressful situation is over. The demand for magnesium goes up with stress. If there are inadequate amounts of magnesium in the body, this magnesium deficiency can in itself sustain a stress response. A magnesium deficiency itself can initiate and maintain a stress response without a trigger to cause the stress in the first place. Low magnesium states can prevent the body from relaxing and cause muscle cramping. After a stressful situation, adequate magnesium is needed to help the body shift over to a relaxed state.
Boarder-line magnesium individuals can have a mental, emotional, environmental or physical state of continuous stress where their bodies never come down out of the stress state. This can be detrimental to health and wellness. Drinking coffee, alcohol, and eating lots of sugary foods will cause the body to become depleted. Today’s diets high in over processed foods are lacking magnesium; one should supplement by either changing ones diet or adding magnesium to their diet in mineral supplement form.
Symptoms of magnesium deficiency include signs such as, muscle cramps or twitches, insomnia, irritability, sensitivity to loud noises, anxiety, nervousness, autism, ADHD, heart palpitations, angina, constipation, spasms in the muscles, headaches, migraines, fibromyalgia, chronic fatigue, asthma and kidney stones (typically caused by a calcium-magnesium imbalance), diabetes, obesity, high blood pressure, menstrual cramps, irritable bladder, irritable bowel, acid reflux, and premenstrual syndrome, depression, low energy, weakness in the muscles, weakening bones (bone density loss), and calcification of organs.
Women who consume high amounts of calcium can actually create a greater deficiency in magnesium leading to greater bone mineral density lost then if no calcium was consumed at all. Foods today that are being fortified with calcium are actually helping women loose more bone density because magnesium is not in the right proportions.
To word off the negative effects of a prolonged or over-reaction to stress including a shortened lifespan, one needs to balance out their magnesium to calcium ratios by adding adequate amounts of both magnesium and calcium to their diet. Supplementing with 400 mgs to 800 mgs of elemental magnesium is critical for one looking to live a healthier longer life that is free from stress.
Keywords: Magnesium Deficiency, Fight Stress, Magnesium, Calcium, Fight High Blood Pressure
Description: Are you feeling tired, sick or maybe you feel like something is wrong but not quite sure what it is? Would you know if you had a magnesium deficiency? Magnesium is involved in over 300 enzymatic functions in the body; learn how it can help you!
April 16, 2008 01:10 PM
Coenzyme Q10 is an important cofactor that is found in nearly every cell of the body. Coenzyme Q10 is naturally produced by the body as well as attained through the foods we eat or in supplement form. With out it, every cell in our body could not produce energy to function and we would die. Coenzyme Q10 has the capability to regenerate antioxidants, protecting cells and DNA from oxidative stress which naturally occurs in the body every day.
Some may say that coenzyme Q10 exists in only one form, but in fact this substance exists in at least three forms in the body naturally. These three forms are CoQ ubiquinone, CoQH ubisemiquinone and COQH2 ubiquinol all of which are metabolically active forms of coenzyme Q10.
Ubiquinone has been commercially available for more than 30 years normally consumed orally, but recently stable forms of Ubiquinol have been made available for consumption which is of great interest by many researchers. The former ubiquinone when ingested had to be reduced by an enzymatically driven conversion from ubiquinone to Ubiquinol in the digestive tract. This conversion is done by the transfer of electrons effectively reducing the coenzyme Q10 to a more usable form Ubiquinol.
Once Ubiquinol is produced the body can more easily manufacture ATP which is directly used by cells for cellular energy. In young individuals, 90 percent of coenzyme Q10 found in the blood is in the Ubiquinol form. This being the case, the old form (ubiquinone) was less absorbable then the newer Ubiquinol that can go right to work in the body. Ubiquinol is considered the strongest lipid soluble antioxidant that is biosynthesized, providing an active defense against oxidative stress that damages, cells, proteins, lipids, and DNA.
Some scientists believe that cellular damage from free radicals cause our bodies to age. The older we get the less our bodies produce coenzyme Q10 which in its self is an antioxidant and restores other antioxidants in the body to fight the war against free radicals. Eating foods rich in antioxidants and or supplementing with antioxidants may slow the aging process.
With age, disease, and some prescription medications, the old form of coenzyme Q10 can not easily follow the process of absorption in the intestinal tract where it is reduced and shuttled through the lymphatic system into the circulatory system (blood). This is why Ubiquinol was so highly sot after. Ubiquinol is already reduced, the preferred form coenzyme Q10 the body wants to circulate and retain.
When one ages, energy levels always drop and one tends to slow down and feel tired sooner in the day, this may be because of a drop in coenzyme Q10 in the blood. Many recent studies suggest that the plasma Ubiquinol ratio is reduced in response to cardiovascular disease, neurodegenerative disease, cancer, fatigue and especially in type-2 diabetes. Supplementing with Ubiquinol can help restore plasma levels and boost ones energy levels and possibly slow diseases.
To sum it up, if you are over 45, suffering from a degenerative disease or cancer, feel tired and run down, or taking prescription medications, conventional coenzyme Q10 is not what you want to take to elevate plasma levels. Ubiquinol is needed because the body can not adequately produce the most abundant form of coenzyme Q10 in he blood (Ubiquinol). So for those who want to maintain health and wellness, look for Ubiquinol in their local health food store.
Papaya- May Be A Fountain of Youth
May 31, 2007 02:09 PM
Papaya- May Be A Fountain of Youth
Seventy years ago, when the Social Security Administration was developed during the Great Depression, age 62 was recognized as average life expectancy. These days, getting older is a whole different ball game. Not only are people living well into their 80s and 90s, they’re living better, too. People well into retirement are mountain biking, kayaking, jogging and hiking, as well as gardening, golfing and attending concerts – sometimes for their first time. Everybody, it seems, is on the go, from ages of 22 to 92.
Of course, you don’t have to wait until retirement to start planning for a longer more vibrant life. The best way to ensure happier and longer years ahead is to start young.
Nobody wants to spend retirement in the doctor’s waiting room or have their golden years intruded upon with illnesses or infirmities. And, most importantly, we don’t want to feel 80 years old even though our driver’s license says we are.
These desires and demands are not just wishful thinking. Huge advances in the understanding of how men and women age are being made almost daily. These findings are helping to improve our chances of living long, healthy lives. And, some of the most impressive findings have shown that using nutritional supplements can help – in particular, a specially formulated papaya preparation is able to fight two of the primary reasons we get old – oxidative stress and immune system decline.
This issue of Ask the Doctor is going to share the anti-aging secrets hidden in the papaya and how this tropical fruit may hold the key to a long, vibrant life.
Q. Why papaya? What does papaya have that other fruits and vegetables don’t?
A. Not many American moms put a papaya in their kids’ lunch boxes and papaya pie has yet to gain a following. But this tangy tasting fruit is now appearing fairly frequently in the produce departments of most grocery stores and its popularity seems to steadily increase each year.
The papaya’s bright orange flesh is fairly fibrous and very slippery – slicing a peeled papaya is a little like slicing a bar of wet soap. The core is filled with little black seeds that look a lot like caviar. And while eating a papaya will give you a day’s worth of vitamins A and C as well as potassium taking Fermented Papaya Preparation (or FPP) might just give you an additional 30 years of healthy vibrant life.
Q. What exactly is Fermented Papaya Preparation (FPP)?
A. It’s a specialized nutritional supplement. Backed by more than 30 studies to date, FPP has been used in
Q. How was FPP developed?
A. Japanese scientists noticed that individuals with higher amounts of papaya in their diets experienced certain health benefits.
Researchers who study aging decided to look at the papaya’s chemistry to see if it might have properties that could contribute to longevity. Several plant chemicals in the papaya showed promise. And when they combined papaya with specific yeasts and traditional Japanese fermentation techniques, FPP was born. This unique substance was then subjected to scientific studies to see its health impact; they determined that FPP is a superior antioxidant, a powerful immune-booster, and one of
Q. How does FPP help people live longer and healthier?
A. While getting older is an indisputable fact of life, aging, per se, is not. We can’t do much about our annual birthdays and we really shouldn’t even if we could. Every age is a cause for celebration and every life experience, both the difficult and the sublime, should be treasured.
However, we don’t have to accept the consequences of aging that can make a mockery of the “Golden Years” - heart disease, Alzheimer’s disease, Parkinson’s disease, osteoporosis, arthritis, and cancer. Our parents and grandparents and the generations that preceded them might have had little say in how they aged. But we can. We can slow down the harmful effects of aging and FPP can help by reducing oxidative stress and immune system decline.
Additionally, fighting oxidative stress helps people retain their youthful appearance longer. Oxidative damage is the number one factor in facial aging.
Q. What exactly does oxidative stress mean and what does it have to do with aging?
A. One theory of aging is that harmful molecules called free radicals wreak havoc in our cells. Many of our body’s normal metabolic processes produce free radicals. For example, free radicals are a normal by-product in the production of ATP (the energy molecule) from glucose. Certain types of white blood cells destroy invading microbes by the production of free radicals. Free radicals are also formed by the many normal enzymatic actions that take place every minute every day.
However, outside sources can also cause free radical formation, as well. If we are exposed to pollutants in the environment, chemicals, additives and preservatives in the food we eat, or even direct sunlight, excess production of free radicals can occur, causing profound damage. This free radical frenzy is called oxidative stress, and is linked to almost every disease of aging including arthritis, heart disease, cataracts, Alzheimer’s disease, Parkinson’s disease, and cancer. In fact, the reason why these are called diseases of aging is because the longer we are alive, the longer we are subjected to these free radical assaults.
Q. How does FPP affect the decline of our immune systems as we age?
A. Our immune systems consist of specialized tissues, organs, and cells, including several different kinds of white blood cells. Each type of white blood cell works in specific ways to keep us healthy and free of disease. They not only stand guard – on the alert for invaders – they can fight and eradicate microbes, too.
However, as we age, our white blood cells become less efficient in keeping viruses and bacteria from infecting us. They often mistake invaders for good guys, like nutrients. As they age, white blood cells may recognize foreign invaders, but be too tired to fight and let them in. This age-associated immune decline also results in single cancer cells being able to “take hold” and grow into tumors. By the time the white blood cells realize their mistake, the cancer is a widespread disease.
That’s why older members of society have more urinary tract infections, more pneumonia, more cases of bacterial meningitis, tuberculosis, herpes zoster, and much more cancer than younger adults do. Moreover, mortality rates for these diseases are often 2-3 times higher among adults than younger people with the same disease.
FPP steps in and takes charge. One kind of white blood cells, the macrophage “eats” and digests bacteria, viral particles, and free radical fragments. Research has shown that FPP helps macrophages work faster and ingest more disease-causing microbes. Scientists have also discovered that FPP increases the production of a chemical protein called interleukin that’s secreted by macrophages. Interleukin plays an important part in wound healing and keeping minor infections from becoming major infections.
Another important immune system cell is the natural killer (NK) cell, a white blood cell that is continually on the prowl for cancer cells. As the immune system ages, NK cells have trouble “seeing” cancer cells. Researchers have discovered that FPP boosts the activity of NK cells. Increased NK cell activity can result in the increased killing of cancer cells as well as cells infected by viruses.
Q. How does FPP help protect us from free radical damage?
A. FPP contains unique and powerful antioxidants. Antioxidants are molecules that neutralize free radical damage. Antioxidants do this by donating an extra electron to the free radical without becoming frenzied or worked up into a free radical themselves. Although the antioxidant has donated an electron, it has a more stable “personality” and is less reactive. This action stops the domino effect and ongoing free-radical damage.
If you consider your body a temple, think of free radicals as stealing bricks from your temple’s foundation. FPP acts not only as policeman, but as a builder as well. It doesn’t just stop the theft of bricks; it helps create new ones, keeping the foundation strong and young.
FPP does this by affecting super oxide dimutase (SOD) and glutathione peroxidase (GPX), the very genetic pathways that eliminate free radicals from the system. FPP is more than an antioxidant – it doesn’t turn into a pro-oxidant if you happen to take a large dose the way standard antioxidants can. Consider it an “antioxidant plus.”
Since aging is largely determined by how well our bodies can fight oxidative damage, using FPP can slow down the clock as it bolsters natural abilities with its own potent neutralizing activities.
Q. What else does science say about FPP?
A. As the subject of over 30 clinical studies, FPP has been shown to inhibit dangerous hydroxyl free radicals. In addition, it is also being considered for its immuno-protective effects.
Researchers and medical professionals have been studying FPP for years, tracking its effect on the immune system and aging. In fact, no less a personage then Dr. Luc Montagnier, co-discover of HIV 1 & 2 virus, has been conducting research on this natural immune booster.
Dr. Montagnier recommends using FPP as part of a tri-therapy (including antibiotics) that reduces the proliferation of the virus and stimulates the immune system. Since FPP has antioxidant and immuno-stimulative properties, it seems like an obvious choice for a combined approach to combating AIDS. Because of the higher free radical production in stage II of HIV infection, Montagnier believes that reducing this oxidative stress at the earliest stage of HIV infection may be a key factor.
In HIV-infected patients, the glutathione system is depressed even at the early stages. As part of a combination treatment, FPP increased the numbers of CF4 lymphocytes helped with weight gain and increased hemoglobin levels.
One scientific study showed the ability of FPP to inhibit dangerous hydroxyl and hydroxyl-like free radicals, while enhancing the production of protective super oxide. Other research by Dr. Lester Packer, a professor of Molecular Pharmacology and Toxicology at the
And, in one randomized, double blind, placebo-controlled clinical trial, patients with cirrhosis of the liver were given FPP or a placebo. The results showed that 81.2% of the patients survived in the FPP group compared to 38.5% of participants in the placebo group.
These studies and many others like it, show that FPP can neutralize the effects of oxidative stress on disease states as well as slowing the normal aging process.
Q. So if we can prevent oxidative damage to our cells AND prevent decline in our immune systems, how much longer can we expect to live?
A. Most theories of aging and almost all researchers who study aging claim there IS a limit to how long the human body can remain viable. However, the oldest age achieved so far was 128 by a woman named Ma Pampo who lived in the
Right now, Japanese women have the longest life span of any country in the world, with an average life expectancy of 85.93 years. Japanese men live an average 78.87 years.
Q. Is FPP safe?
A. Yes, it is. Many health-conscious people in
Q. What is the recommended dosage level of FPP?
A. Dosages of FPP vary depending on individual needs and usage. For basic anti-aging support, 3 grams per day is fine. For additional support, up to 9 grams per day is recommended. To add a boost to your immune system when you need it, start out with 6-9 grams a day for the first 2-3 days (at the beginning of a cold, for example) and then move back down to 3 grams per day.
For individuals looking for optimum immune support, Dr. Montagnier advises morning and evening doses, preferably on an empty stomach.
Do you experience muscle pain and inflammation?
April 25, 2007 03:30 PM
Everyone experiences muscle pain and inflammation due to overuse and exertion. We’ve all had those softball games, weekend camping trips or chore-intensive days when our body lets us know we’ve overdone it.
So, what can you do about it? Well, fortunately, there is a proprietary formula with clinically studied ingredients that provides a natural solution: FlexAgility MAX.
FlexAgility MAX is designed to reduce pain and inflammation due to overuse. Its clinically studied ingredients have been shown to help balance the body’s own inflammatory response. Let’s take a look at FlexAgility MAX and answer a few questions you may have about it.
Q. What is inflammation? Why does it happen?
A. Inflammation is actually an essential part of your body’s natural healing process. When some form of physical stress affects the body, the immune system responds by supplying defensive compounds to the stressed site. This is what causes the fluid build-up, pain and redness we typically associate with inflammation. And until the situation is resolved those symptoms will stick around. So, why is that good? Because without these signals – pain and inflammation – we’d probably do even more damage. In a sense, pain and inflammation are very effective stop signs.
The problem is, if our bodies are continuously bombarded by factors that trigger inflammation, these defenders (and their symptoms) are always around. This can mean unnecessary pain and inflammation following overuse and exertion.
Q. What does FlexAgility MAX have to do with inflammation?
A. FlexAgility MAX provides triple-action activity against occasional pain and inflammation, with powerful antioxidant free-radical scavengers, the enzyme bromelain, and a natural COX-2 inhibitor.
Q. So what is COX-2 and why should I inhibit it?
A. We’ve all been hearing a lot in the news about COX-2 inhibition and may have wondered about its connection to pain and inflammation. Let’s take a look:
Cyclooxygenase is an enzyme that comes in two main types, abbreviated for convenience: COX-1 and COX-2. The COX enzymes regulate compounds involved with inflammation, including prostaglandins. COX-1 is found throughout the body, and maintains the integrity of the stomach lining, circulation and kidneys.
COX-2 on the other hand, cruises along the central nervous system – it’s much more attuned to our brain’s sense of “what hurts.” Primarily activated by inflammatory stress, COX-2 generates prostaglandins – the hormone-like defensive compounds that cause the responses we associate with pain and inflammation due to overuse.
You can understand why so much research has focused on COX-2 inhibition. Decreasing its activity means short-circuiting the “inflammation cascade” that follows occasional overuse.
Because COX-1 is associated with a healthy stomach lining, it is not an enzyme you want to inhibit. Unfortunately, many products don’t know the difference between COX-1 and COX-2 – filing both with one blast.
Fortunately, there are ingredients in FlexAgility MAX that can tell them apart. One of them is IsoOxygene.
IsoOxygene is a patented hops extract shown in scientific studies to significantly inhibit COX-2, while leaving COX-1 alone. And, it is a 20 times more potent COX-2 inhibitor than other tested popular botanic products, including curcumin and grape seed.
Q. How do antioxidants support the body during times of inflammation due to overuse?
A. Overall, the body ahs a pretty darn good repair system. However, oxidative stress due to free radical damage can take its toll, especially during times of occasional physical stress. Free radicals and reactive oxygen species can damage cells, because they are hungry, unstable molecules in search of electrons. To find them, they attack other cells. These pillaged cells then become free radicals themselves, setting off a chain reaction of oxidative stress.
Free radicals are formed during the body’s normal functions, and can have benefits, such as neutralizing viruses and bacteria. However, in doing do, they erode the body’s own antioxidant defenses, too. And, free radicals typically become very active during times of inflammation due to overuse or other stressors.
The good news is that the herbal and antioxidant elements in FlexAgility MAX help support the body’s own natural anti-inflammatory defenses.
Take vitamin C, for instance. This extremely well-known antioxidant has been scientifically studied for its beneficial effects on muscle, collagen and connective tissue health. Collagen and connective tissue is what helps hold us together – literally.
And famous antioxidant, green tea, has been well-studied for the benefits of a polyphenol called epigallocatechin-3-gallate, or simply EGCG. In scientific and clinical studies, EGCG from green tea works as an overall antioxidant, scavenging free radicals, and supporting healthy collagen. In fact, one study showed that green tea polyphenols supported collagen health by 50% versus only 16% in controls.
The green tea extract in FlexAgility MAX is especially focused on these beneficial polyphenols. It’s standardized to contain 70% polyphenols – half from EGCG. The green tea acts in concert with elderberry and ginger in the formula to help prevent oxidative stress to the body due to occasional overuse.
Anthocyanins are natural antioxidants found in berries and vegetables. Black elderberry extract, one of the herbal ingredients in FlexAgility MAX, was shown in scientific studies to be more bioavailable – that is, more readily used by the body – than the natural bioflavonoids of other plants. Again, antioxidants help keep the body in optimum health- especially during times of physical stress.
Ginger, used for centuries in Ayurvedic medicine, provides strong, natural antioxidant activity. In fact, a recent scientific study found more than 50 separate antioxidants in ginger root.
Of course, there are many components of plants that show strong antioxidant properties. A scientific study comparing flavonoid antioxidant activity and inflammation have shown that rutin was the most effective in reducing the inflammation cascade.
Boswellia serrata is a tree found growing in the dry, hilly regions of
Another antioxidant ingredient in FlexAgility MAX, N-acetylcysteine (NAC), even helps the body produce more of its own antioxidants, cysteine and glutathione. In a double-blind, placebo-controlled clinical study, N-acetylcysteine inhibited occasional pain and inflammation due to overuse and attenuated fatigue by 26% compared to controls!
N-acetylcysteine has also been shown in scientific tests to act as an antioxidant, supporting healthy collagen and synovial fluid.
The last ingredient, bromelain, provides the enzymatic pathway used by FlexAgility MAX. Bromelain is a proteolytic enzyme derived from pineapple. Clinical and scientific studies showed benefits from bromelain in reducing pain and inflammation from occasional overuse.
So, there you have it- the triple action of FlexAgility MAX: COX-2 inhibition (and COX-1 sparing), antioxidant benefits, and enzyme support.
Q. Is there another product you’d recommend that I use with FlexAgility MAX?
A. One other product I recommend without hesitation is GS-500, a glucosamine sulfate supplement that has been shown to help build and support cartilage. The body’s connective tissue and cartilage include a natural compound called glucosamine. Supplemental glucosamine sulfate is up to 98% absorbable, so more glucosamine reaches the target structures. It has been clinically studied on its effect in building cartilage.
About Enzymatic Therapy:
Like Chris, Enzymatic Therapy is a trailblazer. Since our founding in 1981, we’ve been leading the industry with innovative natural products. After all, in 1993, Enzymatic Therapy introduced glucosamine sulfate, shown to help build and support cartilage, to the
In the intervening years, Enzymatic Therapy has been at the frontline of innovation and invention. Many revolutionary precuts, including Saventaro, Cell Forte, Heartburn Free, Petadolex Patented Brain Support, Whole Body Cleanse, Earth’s Promise, Hot Plants for Him and Hot Plants for Her have been introduced by Enzymatic Therapy.
One of the newest products, (and the reason you’re reading this) is FlexAgility MAX. FlexAgility MAX works with the body’s own natural anti-inflammatory pathways to relieve pain and reduce inflammation due to occasional overuse. Our proprietary FlexBend of ingredients, combined with antioxidants and the proteolytic enzyme, bromelain, is unique among natural products.
Aloe Vera’s Healing Properties Recognized 1500 years before Christ
April 21, 2007 01:53 PM
Fifteen centuries before the birth of Christ, Egyptian writings acclaimed the miracle plant we know as Aloe Vera, even then referred to as an ancient cure. Cleopatra, Alexander the Great and Aristotle were fans of this strange succulent prized for its soothing, healing and analgesic ability. Indians in central and South America used it to treat burns, kidney and bladder infections, dysentery, stomach and intestinal disorders.
The pulp of the plant has been used to reduce swelling and pain from injuries, while in Mexico its used to treat arthritis and gout. For many years people have kept aloe plants around for emergency burns.
We took a good look at this fascinating botanical wonder. Of the 200 plus varieties, we quickly found that only five or six fit the enzymatic structure for the cosmetic and so-called “medicinal properties” mentioned.
Then while we were studying these succulents in their natural desert setting, we observed the roadrunner bird drinking the juice of the aloe vera, passing up many aloe plants to get to a particular variety, Aloe Barbadensis Miller. We then studied acre after acre and found the roadrunner “peck marks” only on one particular species. The other aloe plants were untouched. In studying this species of plant more carefully, our Houston lab found that, indeed it had much different gel than other aloes.
The products now labeled as Georges “Always Active” Aloe are exclusively from Aloe Barbadensis Miller, the Roadrunners’ choice. George Warren, an Independent research chemist in Houston, Texus developed the special processing method that prevents the spoilage without diminishing the essential properties of the Aloe Vera plant. This new method completely eliminates the anthraquinones that are mildly toxic and can cause irritation to the digestive tract. Aloins are also removed, which give a bitter taste (and the Greenish color) to Aloe Vera juices along with the starches and sugars from the polysaccharide molecular chain and thus, George “Always Active” Aloe requires no refrigeration, and will not spoil in its natural state. This method adds no water, no preservatives and no chemicals of any kind. The finished product looks and tastes like spring water.
Too Little Magnesium Can Cause Health Problems
April 20, 2007 12:04 PM
The Recommended Daily Allowance of magnesium (which is the minimum level needed to stave off deficiency symptoms not the maximum level) varies by age and gender:
Children 1 to 3 years: 80mg, Children 4 to 8 years: 130mg, Children 9 to 13 years: 240mg
Boys 14 to 18: 410mg, Girls 14 to 18: 360mg
Men 19 to 30: 400mg, Men 31 plus: 420mg
Women 19 to 30: 310mg, Women 31 plus: 320mg
Pregnant women 19 to 30: 350mg, pregnant women 31 plus: 360mg
A survey conducted by The Gallup Organization found that 72 percent of adult Americans fall short of the Recommended Dietary Allowance of magnesium.
Because magnesium is required for hundreds of enzymatic reactions (enzymes are protein molecules that stimulate every chemical reaction in the body), deficiency can cause a wide variety of symptoms, such as low energy, fatigue, weakness, PS and hormonal imbalance, inability to sleep, weakening bones, muscle tension, spasms and cramps, abnormal heart rhythms, headaches, anxiousness, nervousness and irritability.
Dr. Carolyn Dean, author of The Miracle of Magnesium states: “The recommended daily allowance (RDA) is about 350mg per day, but most researchers say you need two and three times that amount, partly because it’s not in foods. If it is in foods, if you cook and process the foods in any way, you lose magnesium.”
The Power Plant of the Amazon
March 02, 2007 11:34 AM
It may surprise most Americans to know that rainforest plants are the original source for one-fourth of the chemotherapy medications used today. Plants offer a plethora of beneficial compounds, and rainforests contain a superabundance of beneficial plants.
In fact, plant medicines are the most widely used medicines of all types in the world. Over eighty-five percent of the world’s population uses plant and herbal medicines as their primary medicines. That’s 5.1 billion (5,100,000,000) people worldwide! While Americans overwhelmingly use synthetically manufactured pharmaceuticals to cure their ills, the vast majority of Earth’s inhabitants use healing plant medicines instead.
One of the most powerful healing rainforest plant medicines is cat’s claw, or Uncaria tomentosa. This high climbing woody vine grows at the base of tall trees in the Peruvian rainforest. The plant’s claw-shaped thorns latch onto the trees and spiral further upward, nourished by the lush rainforest environment. For over 2,000 years, the Ashaninka, a tribal people of the Peruvian rainforest, have used the root of U. tomentosa to treat illnesses in the tribe, including asthma, bladder infections, infected wounds, arthritis, bone pain, bowel inflammation, and cancer.
Q. I’ve heard about cat’s claw, but what does it do and how do I know which one is right for me?
Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today. One reason that it’s so confusing is there are so many kinds of cat’s claw supplements-there are cat’s claw leaves, cat’s claw bark, and even cat’s claw twigs. While each of these supplements claim to help the immune system, it is the root of Uncaria tomentosa that is proven to impart the true cat’s claw health benefits.
Scientists, who have extensively studied every part of the plant, discovered that extracts made from selected cat’s claw roots possess the healing power to treat and prevent diseases like cancer, rheumatoid arthritis, ulcers and degenerative diseases. In addition, it demonstrates anti-inflammatory, anti-viral and anti-microbial benefits.
Adding to the confusion is the fact that not all Uncaria tomentosa roots actually contain healing properties.
Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. The Ashaninka healers, or sancoshi, are able to actually “see” the good spirits hidden inside the root of the plant before they harvest them.
Some cat’s claw plant roots have the good spirits. Some don’t. If the good spirits are mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no apparent differences in the plants or the roots to the untrained eye, only certain cat’s claw roots possess the power to heal. And, for a very long time, only the Ashaninka tribal healer seemed to be able to identify them. They call the good spirit cat’s claw Saventaro, or “powerful plant”.
However, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they could “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to be important medicinal compounds called pentacyclic oxindole alkaloids (POAs). Research has learned that POAs provide powerful benefits for the human immune response.
Q. Why are good spirits, or POA’s, good for the immune system?
Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.
Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest m ore bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin that is secreted by macrophages. This macrophage-secreted interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals that are essential to an activated immune system.
POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies. And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T cells, Suppressor T cells, and Killer T cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.
Q. Can cat’s claw and other plants in the rainforest really cure diseases? Isn’t that just folklore?
It’s folk use and modern science combined-plants have long been known for their ability to kill cancer cells. In fact, the National Cancer Institute (NCI) has identified over 3000 plant extracts that can kill cancer cells. More than 70 percent of these plants are found only in the rainforest.
Q. What is it about the rainforest that gives plants like cat’s claw these cancer killing compounds?
Most of the time when we talk about rainforests, we’re talking about the tropical rainforests. While other forests, like the old-growth temperate forests of the Pacific Northwest, also have high rainfalls and tall trees, the tropical rainforests located near the equator are where most plant medicines come from.
The Amazon rainforest in South America is the world’s largest, covering an area about two-thirds the size of the continental United States. Depending on the elevation and distance to the equator the Amazon rainforest receives between 160 and 400 inches of rain per year. The rain is spread pretty evenly from January to December-it’s always the rainy season-and the temperatures remain between 75-80 degrees Fahrenheit all year.
This fertile environment continually recycles itself. When leaves fall from the trees, flowers wilt, and animals die in the rainforest-all of the nutrients are recycled back into the roots of the trees and plants. Because the rainforest reuses almost everything that falls to the ground, the plant growth is amazingly rich in alkaloids and other medicinal compounds. Researchers think these compounds and alkaloids, like POAs, protect the plants from illness and insect attacks. These are the very same compounds that protect us from disease.
Q. When the Ashaninka harvest the cat’s claw roots, does it impact the rest of the plant?
No. The Ashaninka work intelligently to keep rainforest cat’s claw plants perpetually healthy. The Ashaninka employ responsible and innovative harvesting techniques to keep the plants alive and tribal members healthy. Individual cat’s claw plants are never completely harvested. Only one third of the lateral roots are collected at any one time to allow re-growth by the remaining root. Once a plant’s lateral roots have been partially harvested, that plant is left to regenerate, and no more root is harvested from it for 10 years.
Q. Why are the Ashaninka willing to share their cat’s claw?
They are generous people. The Ashaninka see no benefit in hoarding cat’s claw for themselves alone. They also want to make sure that the plant’s healing properties continue on. As their homelands continue to be destroyed by deforestation, rainforest peoples are also disappearing. There were an estimated ten million tribal and indigenous peoples living in the Amazonian Rainforest in 1510. Today there are less than 200,000.
Since the 1900’s more than 90 indigenous tribes have died out and disappeared. Each time a rainforest medicine man or woman dies without passing their arts on to the next generation, the tribe and the world loses thousands of years of irreplaceable knowledge about medicinal plants. With them, centuries of accumulated knowledge of the medicinal value of rainforest species have been lost.
A good example of the impact of this loss can be seen in cat’s claw. When European explorers began venturing into the Amazon River basin, t hey were skeptical of the stories the Ashaninka people told them of U. tomentosa’s amazing healing powers. But when the explorers became sick with colds, flu, or other illnesses, they harvested cat’s claw root for themselves and gave the plant a try. Sometimes the explorers got better when they used the cat’s claw root, sometimes they stayed the same.
Q. Why didn’t the cat’s claw root help all the explorers?
Because some cat’s claw plant roots have good spirits-POAs-and some cat’s claw plant roots have tetracyclic oxindole alkaloids, or TOAs. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all. All U. tomentosa plants look virtually identical, so it’s hard to tell if they have the healing POAs or non-helpful TOAs.
What makes cat’s claw identification even more challenging is the fact that plants with POAs one year will have TOAs the next. Cat’s claw plants seem to change their alkaloid chemotypes at will, an incredibly powerful accomplishment for a plant to possess. Harvesting of cat’s claw roots that contain POAs is very tricky. Unless the person gathering the root extract is an Ashaninka sancoshi. These medicine men know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root. When scientists studying cat’s claw discovered they could “see” presence of TOAs using HPLC technology, they were able to harvest cat’s claw root extracts with POAs that consistently helps people get and stay healthy.
Q. Do some cat’s claw root extract supplements contain TOAs?
Yes they do. And buying those products will only benefit the cat’s claw distributor; they won’t help you stay healthy. When cat’s claw root is harvested from the rainforest, responsible supplement maker examine the root with HPLC to make sure that only POA roots are collected. But, this identification of the chemotypes takes significant time and costs money. For these reasons, many cat’s claw distributors don’t include this important process in their harvesting. The POAs and TOAs are simply just mixed together and sold as a cat’s claw product with no mention of any alkaloid content on the label.
Q. Why should I avoid TOAs?
While the POAs in cat’s claw root extracts have numerous benefits to the immune system, the TOAs have different effects in the body, none helping the immune system cells. Most importantly, however, when POAs and TOAs are mixed together, the TOAs actually work against the POAs. TOAs reduce the capacity of POAs to beneficially modulate the immune system.
Q. How can I be sure the cat’s claw I buy is POA cat’s claw?
Read the label of the cat’s claw root extract product you are considering buying. If it does not clearly state that it is the high POA cat’s claw, then chances are that it’s not.
Q. What do the Ashaninka receive in return for the cat’s claw harvesting?
The Ashaninka and reputable distributors of cat’s claw root extract have established a mutual and ethical relationship. Both groups benefit from the sale of the plant material. Maintaining this relationship is important for both the tribe and the distributors.
The distributors are paying a fair price for the raw material directly to the tribe. No intermediary is involved. This payment covers the raw material itself, a license-fee for the k knowledge of the plant, and a guarantee (from both sides) of a lasting relationship. Payment is also made for the protection of the rainforest. No deforestation is allowed. The area where the cat’s claw materials are processed is also leased and payment is made for this, as well.
This arrangement allows the Ashaninka to make independent decisions in how to spend this income from sale of their cat’s claw plants. They have been able to make improvements in the tribe’s water supply and in their living areas. They are also able to obtain outside medical aid as needed and provide for education of their children.
The partnership with cat’s claw distributors has created a sustainable resource for the Ashaninka. The tribe has been able to not only preserve their rainforest, but also compete financially with unsustainable income sources offered by timber and agricultural firms.
Q. Why is it important to preserve the rainforest?
The most amazing fact about these impressive medicinal plants is the vast number that5 has yet to be discovered. In fact, the rainforest’s abundance is one reason it is home to so many healing plants. Within a four square mile patch of rainforest, you could see 1500 species of flowering plants, 750 species of trees, 125 mammal species, 400 species of birds, 100 reptile species, 60 amphibian species, and 150 different species of butterflies.
Unfortunately, not everyone looks to the rainforest for the same reasons. Many consider its real value in board feet and cultivated acreage. The forces pushing industrial development move quickly; experts estimate that we’re losing over 130 plant, animal, and insect species every day/ That amount to almost 50,000 species a year.
A combination of logging, petroleum interests, cattle grazing operations, and, of course, our own consumer appetites are putting pressure on rainforest resources. The consequences are sobering:
By leaving the rainforest intact, however, and harvesting its many nuts, fruits, oil-producing, and medicinal plants, the rainforest has more economic value than if it was cut down for timber or to make grazing land for cattle. If managed properly, the rainforest can provide the world’s need for sustainably harvested natural resources on a perpetual basis. That’s what the Ashaninka are doing with their cat’s claw harvesting.
The discovery of medicinal plants is dependent upon healthy rainforests. When an acre of tropical rainforest is lost due to deforestation, the impact on the number of plant and animal species lost and their possible uses is staggering.
We can all help the development of sustainable rainforest industries. By purchasing renewable and sustainable rainforest products, like POA type cat’s claw root extract, we are keeping rainforests alive and well. By benefiting from the innate wisdom of the Ashaninka people we are keeping ourselves just as alive and well. By honoring the science and the sacred of the world’s rainforests, like my friend the oncology nurse, the massive wealth and diversity will be there for generations to come.
Which Calcium is Best?
October 17, 2006 03:52 PM
Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many models—some are basic and others are more sophisticated.
Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit.
Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process:
1. Do you prefer tablets, capsules, softgels, liquid or powder?
2. Do you have high or low stomach acid?
3. Do you have absorption issues?
What is calcium?
Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded.
Where does calcium come from?
Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust.
Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption.
Lets look more closely at the different forms of calcium that are available as supplements.
Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements.
Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas.
Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills.
Calcium Citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further.
Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless.
Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice.
Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians.
Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids.
Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory.
So, which form is best?
Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:
Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us.
*HVP = Hydrolyzed Vegetable Protein
Remifemin symptomatic relief, scientifically supported*
August 26, 2006 02:41 PM
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*this statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treate, cure, or prevent any disease.
How Does It Work?
July 08, 2006 01:24 PM
Proprietary Probiotic blend
Acidophilus Pearls is a probiotic dietary supplement designed to help support digestion and a healthy intestinal system. Probiotics, such as lactobacillus acidophilus and Bifidobacterium longum are live microbial food supplements that are non-toxic and do not cause disease (non-pathogenic). Probiotics do not permanently colonize in the body. Therefore, they need to be ingested regularly for their health-promoting effects to persist. After ingestion, probiotics must adhere to the wall of the intestine. Once attached to the intestinal wall, the bacteria are capable of multiplying and colonizing in the gut, thereby enhancing the immune response. 1-3
Oral probiotics help support the composition and metabolic activities of the large intestine micro flora.1 Micro flora of the large intestines assist digestion through fermentation (making the intestines inhospitable to invading species), protection against pathogenic bacteria, and stimulation of the development of certain components of the immune system.3 Lactobacillus acidophilus and Bifidobacterium longum occupy a central role in the guy micro flora, thereby enabling them to influence the composition of the micro flora to provide health benefits.4
Breakdown of Lactose
Lactose is an important sugar that is converted to lactic acid by lactic acid producing bacteria (such as lactobacillus acidophilus and Bifidobacterium longum).6 Lactose intolerance results from an inability to digest lactose.7 Lactose intolerance may be due to genetics, age related declines in intestinal lactase (the enzyme that metabolizes lactose), or other reasons.8 Lactase deficient people accumulate non-absorbed lactose in the gastrointestinal tract, which draws water and electrolytes into the gut and accelerates transit time, which can lead to diarrhea.2,8 Lactic acid bacteria can help metabolize the non-absorbed lactose in the gastrointestinal tract.
In a randomized, controlled clinical trial, Bifidobacterium longum was shown to support the breakdown of lactose and reduce the symptoms of lactose intolerance (flatulence) in people with lactose intolerance.5
Immune system support
While a normal micro flora is associated with good health, changes in intestinal health are associated with altered immune function. A well-functioning gastrointestinal immune system mediates immune responsiveness at mucosal sites and throughout the entire body via the control of quality and quantity of foreign substances gaining access to the immune system.9
Lactobacillus acidophilus and Bifidobacterium longum have shown to possess immunoprotective/immunomodulatory properties. These benefits include modulation of: cytokine and various interleukin production, autoimmunity, natural killer cells cytotoxicity, lymphocyte proliferation, and antibody production.3
In an open, randomized, controlled trial, Lactobacillus acidophilus and Bifidobacterium bifidum were supportive of colon health in older adults. In addition, B cell (important antibody producing immune cells) levels increased as compared with the untreated group. The probiotics were very well tolerated, with no significant side effects or variations in clinical chemistry or hematologic parameters.
Decrease Occasional Constipation
Constipation is defined as infrequent or difficult defection that can result from decreased motility of the intestines. It is a common problem, particularly in older adults. When the feces remain in the large intestine for prolonged periods, there is excessive water absorption, making the feces dry and hard.7
Insufficient amounts of lactobacillus acidophilus and Bifidobacterium longum may play a role in delayed bowel movement, which can favor the activity of undesireable putrefactive bacteria (bacteria that break down organic matter into potentially harmful compounds) in the intestines. Lactic acid bacteria contribute to the re-establishemtn of healthy intestinal flora (at the expense of pathogen growth) and stimulation of intestinal peristalsis via lactic acid. 10
Support of putrefactive Processes
When unbalanced conditions are present in the intestines (ie, unbalanced diet, high acidity, and/or low levels of lactic acid bacteria), organic matter may be putrified (decomposed or rotting) by certain bacteria and produce harmful substances such as ammonia.1,11
Micro flora or the large intestines promote homeostasis (balance) in both the intestine and the vagina.1,12,13 these activities are carried out via support of direct production of antibodies, competition with adhesion to intestinal cells, or indirect modulation of the immune system.2
Normal micro flora of the large intestine help support and complete digestion via fermentation.1,11 The risk of diarrhea, for example, increases when the capacity of colonic micro flora to ferment carbohydrates decreases.8 Oral ingestion of probiotics produces a stabilizing effect on the guy flora.2
The benefits of probiotics extend beyond digestion support and immune support. Lactobacillus acidophilus and Bifidobacterium longum also help support the better utilization and bioavailability of nutrients, including vitamins, minerals, proteins, fats, and carbohydrates.14
Candida albicans is a fungus that is a naturally occurring component of normal gastrointestinal micro flora.15 however, C. albicans should be maintained at healthy levels. Probiotics have been shown to help retain healthy levels of C. albicans that are already within normal limits.
True Delivery Technology
Recently, our Enzymatic Therapy laboratory tested four leading probiotics nutritional supplements in the marketplace. These supplements were best selling brands, two of the supplements were enteric coated, and all had label guarantees about potency (guaranteed number of live bacteria). The laboratory scientist counted the levels of living bacteria found in compared these findings to the bacterial levels claimed by each manufacturer. The products were also subjected to a simulation of stomach acid conditions, after which the levels of living bacteria were re-counted.
The laboratory results found the probiotic supplements contained less than 50% of the number of living bacteria that they clamed on their labels. Furthermore, the laboratory results found that only 10% of the liver bacteria clamed on the manufacturer’s label survived the simulated stomach conditions.
Acidophilus pearls used a revolutionary proprietary “pearl” encapsulation process called True Delivery Technology. The True Delivery Technology is a special type of natural coating that protects the probiotic bacteria.
The True Delivery is a seamless “pearl”, which consists of three layers. The inner layer is a paste of probiotic bacteria suspended in a protective oil suspension. The second layer actually “seals” the bacteria in the capsule, which protects them from air, moisture, and the effects of heat. Probiotic bacteria are anaerobic organisms (grow in the absence of oxygen) and the presence of oxygen can actually injure or kill them. Because probiotic bacteria are injured or destroyed by the acids of the stomach, the third, outermost layer of the pearl is specially developed to only dissolve in the alkaline environment of the intestines. This patented gelatin pearl protects the probiotic bacteria from the acid environment of the stomach, so that they can successfully reach the intestine.
The patented seamless pearl capsule of Acidophilus Pearls assures the virtually all the bacteria remain uninjured and healthy to colonize in the intestine. In addition, the special pearl capsule’s ability to seal the bacteria inside it eliminates the need for the nutritional supplement to be refrigerated – though they can be kept in the refrigerator, if desired.
Store at controlled room temperature, 59 degrees F to 86 degrees F (15 – 30C). May refrigerate if desired
This statement has not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The healing power of borage oil
June 19, 2006 01:27 PM
Borage oil, extracted from the seed of the blue, star shaped borage flower, is gaining much attention by alternative health practitioners and main stream medicine alike for its profound medicinal properties. Whereas the oil is getting all the redit, it is actually the oil’s active component, gamma linoleic acid (GLA), which has drawn the interest of researchers. The majority of the early studies done on GLA, dating back to the late 1940’s, were conducted with the oil of evening primrose. For rezones cited in the title, more bank for the buck, borage seed oil is now thought to be s superior source of GLA compared to evening primrose oil. Other plants forms and food concentrates that contain appreciable amounts of GLA include black currant seed oil and spirulina.
Why GLA Supplementation?
A body with healthy biochemistry has the ability to produce GLA from the most essential fat linoleic acid. Linoleic acid is found most abundantly in the omega 6 family of oils, including safflower, sunflower, and corn oil. While it has been estimated that a majority of Americans and Europeans consume far to many omega 6 fatty acids in proportion to the beneficial omega 3 fatty acids (by approximately 10:1). Most biochemists agree optimal ratio of omega 6 to omega 3 fatty acids should be approximately 1:1. Despite the obvious over consumption of omega 6 oils rich in linoleic acid, some individuals lack the ability to convert linoleic acid to the much needed GLA.
As is the example with many of our modern day nutrient deficiencies, the adulteration of our food supply by today’s processing methods has much to do with the faulty fat metabolism suffered by many. A prime example is the hydrogenation process utilized to convert liquid polyunsaturated oils into semi-solid, altered saturated fats for use as margarine and commercially processed foods. Hydrogenation is accomplished by subjecting the oils to temperatures in excess of 250 C, and bombarding them with hydrogen ions in the presence of the heavy metal nickel, which irreversibly changes the chemical structure of the fatty acid molecule from a healthful “cis” configuration to a dangerous “trans” configuration. When these products are eaten in excess they are known, in some cases, to block the enzymatic conversion of linoleic acid to GLA. In addition to the damaging effects of hydrogenation, certain essential fatty acid nutrient cofactor deficiencies may exist to further complicate the conversion. Vitamins pro-A, A, C, E, B-2, B-3, B-6, pantothenic acid, B-12 biotin and the minerals calcium, magnesium, potassium, sulfur and zinc are all involved in essential fatty acid (EFA) metabolism.
Particular interest should be given to those afflicted with diabetes, cystic fibrosis, asthma, alcoholism, multiple sclerosis. For a myriad of reasons, including cofactor deficiencies, these individuals lack the enzymatic ability to convert linoleic acid to GLA and must obtain a direct source of GLA for proper hormonal regulation. In addition, excessive consumption of animal fats containing acachidonic acid competes for the same metabolic pathways occupied by GLA, thus minimizing its biological action.
These potential negating effects can simply be diverted to consuming a food source or supplement containing GLA which bypasses any previously necessary enzymatic conversion and floods the metabolic pathways with beneficial GLA. Nutrient deficiency should also be addressed. Here lies the true power of GLA.
Prostaglandins, biochemical regulators
Whereas GLA is the power, the prostaglandins deliver the punch in this biological equation. Just as linoleic acid is normally converted to GLA, GLA is further converted into the prostaglandin E1 (PGE1). Many of the benefits derived from GLA supplementation are a result of the hormonal regulatory action of the prostaglandins. Just like the “parent” precursors they are made from, the hormone-like prostaglandins orchestrate a host of important biochemical activities. Their general regulatory effects include the control of arterial muscle tone, sodium excretion through the kidneys, blood platelet “Stickiness,” inflammatory response and the immune function, just to name a few. The list may be endless as scientists continue to discover the regulating effects of prostaglandins. One way in which GLA has shown to decrease the probability of allergic and inflammatory conditions is by competing with arachidomic acid, which when left unchecked may potentiate a hyperimmune response.
As a result of the powerful regulating effects derived from the conversion of GLA to healthful prostaglandins, borage oil and other GLA supplements have shown to be beneficial in the treatment and relief of many classic and modern day health problems. The disease of diabetes, cystic fibrosis, asthma, multiple sclerosis are thought to be helped by bringing about a balance in an otherwise faulty fatty acid metabolism. According to a study released in the journal diabetes care, supplementation with GLA has shown promise in the reversal of diabetic neuropathy (a condition where the nerves degenerate and symptoms of pain and numbness follow). The study concluded that all diabetics should be considered for dietary protocol of GLA. Other conditions shown to benefit include high blood pressure, high cholesterol, skin conditions, arthritis, allergies, weight loss, improved behavior of hyperactive children and increased strength of hair and nails. Cited in the book, Super Nutrition For Menopause, written by the renowned nutritionist Ann Louise Gittleman, is one of the most popular applications of GLA supplementation in the relief of menstrual pain. Sufferers use a maintenance does up to the seventh day prior to menstruation, then double the dose for the duration of their menstruation. Dietary restrictions of meat, dairy and eggs during this time has also shown to compliment this regiment. Many would agree with Ms. Gittleman’s credo in allowing mother nature to cure our ails before relying on synthetic drugs which often come with side effects.
More Bang for the Buck
Now comes the challenge of acquiring a GLA supplement suited to meet your needs. With the help of the information below you may maximize your desired result while at the same time stretching your dollars. Lets take a look at the facts. We will limit out narrative to the tree most popular forms of GLA supplementation: 1) borage oil, 2) evening primrose oil and 3) black current seed oil. Potency is an important factor, as the higher the GLA content per gram, the more likelihood of greater biological activity. Borage oil contains 24% GLA, or 240mg per 1000 mg capsules. Black current seed oil contains 18%, or 180mg per 1000 mg capsule and evening primrose oil contains 10% GLA, or 100mg per 1000 mg capsule. While black currant seed may appear to run a close second to borage and have a slight edge on evening primrose, it contains a potent GLA inhibitor and should be considered last on the list. equally, if not more important than potency, is purity. Make it a practice not to purchase any oil product unless full disclosure of the method of extraction is printed on the label. If it is not, you may assume that the oil has been extracted in one of the following ways. Unfortunately, the popular use of the chemical hexane to extract oils is not required for disclosure. This method employs submerging cracked seed in a gasoline like substance (Hexane) and then slowly allowing it to evaporate off yielding 90% oil recovery. This is the most common method used to extract evening primrose oil because of the incredibly small, hard seed and low oil content. The second creative ploy is the claim that the oil has simply been extracted by a new high-tech method called supercritical fluid extraction (SCFE). This process “pregrinds” the seeds then subjects them to pressures of 6000 – 10000 psi in the presence of the gas CO-2. Under such intense pressure CO-2 gas becomes a liquid in which the seeds are submerged, ultimately yielding a 95% oil recovery. Look for oils that are labeled as “expeller pressed” without the damaging effects of light, heat and oxygen. The products should be contained in opaque (light resistant) bottles to protect them from the damaging effects of light. Optimally, you should find them in the refrigerated section of your local health food store. Due to the higher percentage of oil contained in the borage seed, as compared to evening primrose and black current, borage is typically priced well below the others making it the most potent and economical choice. All things considered an expeller pressed borage oil, contained in an opaque plastic bottle, may provide you the absolute best source of unadulterated GLA supplementation.
One company that provides such a product and always fulfills the quality requirements listed is Barlean’s Organic Oils. Their organic flax oil and borage oils are available at VitaNet.
Promise of Evening Primrose Oil
June 03, 2006 01:11 PM
Today, we know that the oil from the seeds of evening primrose contains a high amount of the active ingredient, gamma-linolenic acid (GLA), an oil quite similar to other essential fatty acids (EFA) of the omega-6 variety. In fact, evening primrose oil is one of the few substances found in nature that contains significant amounts of GLA. It was only as recently as the 1970’s that researchers discovered among its potential therapeutic benefits, GLA aids the body’s formation of important prostaglandins (known as PGE1) that moderates inflammatory processes. (Prostaglandins are molecules that act as vital cell regulators.)
While the body manufactures gamma-linolenic acid from linoleic acid, one of the essential fatty acids, optimal production is often inhibited by dietary deficiencies, age related enzymatic deficiencies and intake of excess amounts of saturated fat. Indeed, it is interesting to note linoleic acid has little to no biological activity in and of itself. It’s true value is in its conversion to GLA. When we take additional GLA, we encourage increased formation of PGE1, which produces a variety of health benefits.
Health experts say that prostaglandin E1 series aids the body by inhibiting or reducing inflammation, blood clumping, blood clots, abnormal cholesterol production and formation of malignant cells. (In particular, GLA reduces risk of arterial spasm and abnormal clots, important factors in heart attacks and strokes. Another beneifit is lowering blood pressure.) The PGE1 series also maintains important electrolyte balances and normalizes insulin secretions.
Other health conditions that can benefit from GLA include arthritis; skin disorders such as eczema, acne, dermatitis; allergies and asthma; premenstrual syndrome; multiple sclerosis; fibrocystic breast disease; and depression.
Enzymatic Therapy is celebrating 25 years as a leader in quality & innovation!
May 09, 2006 12:31 PM
Enzymatic Therapy is celebrating 25 years as a leader in quality & innovation!
It’s hard to believe that 25 years have passed since Enzymatic Therapy was founded with the goal of delivering powerful natural medicines and supplements backed by solid research and scientific evidence. Through the years we have continued to innovate and elevate the standards of excellence in our industry, thanks to imput and support from great people like! As we look forward to even greater success together in the future, we want to take this opportunity to celebrate the savings on some of our most popular products. Thank you for your part in helping us make an amazing 25 years and here’s to a bright future for us all from Enzymatic Therapy!
What are the complications of diabetes?
April 01, 2006 02:16 PM
The complications of diabetes happens in both types of the disease. All diabetics complications are caused by chronically high blood sugars. The longer your blood sugar levels are elevated, the greater your chances are of having complications.
High blood sugar damages blood vessels. When high levels of sugar are continuously in the blood, the blood vessels become thicker and less flexible, causing poor circulation. Poor circulation can impair healing, especially on the feet and lower legs. High blood sugar also causes higher levels of fat in the blood stream. The fat clogs and narrows the blood vessels. Partial blockages deprive the heart and some necessary nutrients. A complete blockage can result in a heart attack, heart pain (called angina), or stroke.
Nerve damage makes it hard for your nerves to send messages to the brain and other parts of the body. It may cause you to lose feeling in parts of your body or have a painful pins-and-needles-like feeling. While nerve damage most often affects the feet and legs, it can also affect other parts of the body.
Diabetes can damage and weaken the small blood vessels in the retina, the part of the eye that is sensitive to light and help you see. When the blood vessels are weak, they can leak fluid, which causes swelling in the eye. The swelling blurs your vision. If the eye damage gets worse, your eye attempts to fix this damage by making new blood vessels are fragile, they can break open easily and bleed into the eye. Scar tissue can then form. This may cause the retina to break away from the back of the eye, which lead to visual impairment-even blindness.
Diabetes can also damage the blood vessels in the kidney so it cant filter out the body’s waste. High blood pressure is also associated with kidney damage. If you have diabetes and high blood pressure, it is important to keep them both under control as much as possible. The longer blood sugar levels are left uncontrolled, the greater the amount of kidney damage that can occur. If the kidney damage isn’t stopped, some individuals may progress to needing kidney transplants or dialysis machines.
All of these complications however can almost always be prevented.
New Frontiers in Enzyme Supplementation
February 16, 2006 04:17 PM
New Frontiers in Enzyme Supplementation
By Nick Rana, CN, NOW Quality Assurance
Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.
Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.
The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.
Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.
Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.
The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.
Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).
While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).
The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.
Policosanol Cholesterol Complex
February 03, 2006 03:50 PM
Maintaining your Bone Health
January 28, 2006 03:16 PM
Which womam should be concerned about Calcium?
Maintaining your Bone Health*
No matter your age, it’s never too late (or too early) to do all you can to keep your bones healthy. As women age, their bodies require additional bone supplrt that involves far more than just calcium. Let Enzymatic Therapy Lifestage system for Women help you take control of your bone health naturally with three great options – each specifically targeted for one of the three lifestages.*
New! OsteoPrime Plus – a new formula that includes Natto K2, which is clinically shown to enhance calcium absorption and bone building function.*
Clinically proven ingredients
December 29, 2005 12:06 PM
Did you know that poor digestive function is a contributing factor in more than ninety percent of America’s serious health issues?! The waiting rooms of doctors are jam packed, in part because so many people are suffering with gastrointestinal problems. The medical establishment and alternative health and wellness practitioners don’t always agree, but both sides are certain that a healthy digestive system is the cornerstone of good health. Proteins, the building blocks of life; carbohydrates and fats, your body’s source of energy; vitamins and minerals; and water – all are assimilated through digestion. If you’re not properly digesting the foods you eat, your body isn’t obtaining the nutrients it needs to repair, renew and thrive. Without the raw materials it needs to repair the damage we do to ourselves every day, your body begins to break down, leading to poor health and accelerated aging2,3.
While there are a multitude of factors involved in healthy digestive function, one of the most important is the delicate balance of bacteria found in the human gastrointestinal (GI) tract. There are three main types of flora in the human GI tract - Bifidobacteria, Bacteroides and Eubacterium. Of slightly less importance are Lactobacilli, Streptococci and Peptococci and other transitory flora1. Our stomachs and intestines are populated by hundreds of billions of these bacteria, or microflora. Amazingly, there are more probiotic organisms in our gut than there are cells in our bodies! That’s a lot of bacteria, but it’s GOOD bacteria, and each strain has specific functions in the human body. These bacteria aid the digestion of food and have protective qualities that contribute to good colon health. While a good balance of these different microflora is necessary, there are many factors that can, and do, disrupt this balance –certain medications, a poor diet, infection, stress, bad bacteria, aging and even the climate. The good news is a rapidly expanding body of research suggests that supplementing the diet with the right mix of microflora can have a beneficial affect on gastrointestinal function, and therefore overall health.
NOW® Gr8-Dophilus™ exclusively utilizes the finest strains from Rhodia Incorporated, the world’s leading supplier of high quality probiotic ingredients, and is enteric-coated to ensure that the bacteria in this product are not destroyed in stomach acid but reach the small and large intestines where they are most beneficial. Gr8-Dophilus is a vegetarian product that contains virtually no lactose.
Lactobacillus acidophilus is a well-studied microflora species that’s highly resistant to gastric acidity and is able to proliferate in the presence of bile. Like many probiotic organisms, it also adheres well to intestinal cells, helping to prevent the adherence of certain enteropathogens5.
Lactobacillus casei is a microflora strain that is found in the human mouth and intestines as well as in fermented vegetables, milk and meat. Recent research has shown that this bacterium is active in the GI tract and may help to modulate the immune system*. Research is continuing into this very promising probiotic.
Lactobacillus rhamnosus, like Lactobacillus acidophilus, is highly resistant to gastric acidity and proliferates well in bile. It, too, adheres well to intestinal cells. We’ve included this particular strain because it works extremely well with L. acidophilus. Lactobacillus salivarius is a strain that has proven highly effective against Helicobacter pylori, a bacterial species implicated in a number of digestive conditions. Studies have shown that L. salivarius is capable of producing high amounts of lactic acid, which has been shown to inhibit H. pylori growth in live subjects. Compared to other Lactobacillus strains, L. salivarius was proven to have the greatest inhibitory effect on the proliferation of H. pylori,4 which is why this strain is included in Gr8-Dophilus™.
Streptococcus thermophilus bacterium are isolated from yogurt and are recommended for lactose intolerant individuals to help digest lactose in the intestines. This strain is included in this formula to assist in the acidification of the intestinal environment, as well as to create a favorable environment for lactic acid bacteria.
Bifidobacterium bifidum is one of the workhorses of the large intestine. It has a high tolerance to gastric acidity, and, like L. acidophilus and many other probiotic organisms, it adheres well to intestinal cells, helping to prevent the adherence of certain enteropathogens5.
Bifidobacterium longum is a bifidobacterium of human origin that, like lactobacillus, is extremely resistant to gastric acid and bile salts. Because it’s anaerobic (able to live without oxygen) it’s perfectly suited to colonize the colon. Initial studies have shown that this particular strain of bifidobacteria helps to support the immune system*. It also seems to decrease enzymatic activity in feces. Researchers believe enzymatic activity in feces may contribute to carcinogenesis.
Bifidobacterium lactis is one of the most well-studied strains of probiotic bacteria, with a wealth of peer-reviewed, published research on its benefits. Clinical trials on B. lactis have shown it to be helpful in a number of digestive conditions, including diarrhea and lactose intolerance, as well as immune response modulation.
GliSODin Anti-Aging and Antioxidant Protection
December 19, 2005 08:47 AM
GliSODin Anti-Aging and Antioxidant Protection
In the time it takes you to finish reading this article, you, your body and your cells will have aged. Some, more than others. Nevertheless, every second that ticks away should serve as a reminder that our time here is temporary. How much time we actually end up with depends on many things. Diet. Lifestyle. Environment. Superoxide Dismutase? I’ll explain. What some of the healthiest individuals fail to realize is that our bodies age from the inside out. Aging is not the result of passing time, but rather the result of what we’re exposed to environmentally, physically and chemically. It is the integrity of our cells, not our clocks, that determine how smooth the aging process fares.
Each day, we’re subjected to millions of elements that affect us in ways seldom seen, felt or noticed. From the moment we’re born, we rely on our cells to work around the clock - producing energy, fighting infections and sustaining life. These same cells eventually determine the rate at which we show (or hide) our age.
Taking into consideration that our planet has no shortage of toxins & germs, the need to safeguard our cells becomes very real. Constant exposure to exhaust, secondhand smoke, heavy metals, lead, fluoride and uncountable other noxious compounds should ideally provide us with nothing more than a routine immune system workout. Unfortunately, over long periods they hinder our “resistance” abilities and become stepping stones to accelerated aging.
Antioxidants. We’ve all heard the term before, and may even have a general understanding of their role. But to better grasp just how vital they are, it helps to know what’s happening at the cellular level. Free radicals are unstable molecular thieves that often lack electrons. To compensate, they rob healthy cells - a process better known as oxidation. Antioxidants work with the immune system to prevent oxidation, and clean up the mess it leaves behind. Hence, the name.
There are two types. Exogenous antioxidants are derived from our diet and include vitamins A, E, and C along with others such as alpha lipoic acid, selenium, CoQ10, grape seed, pycnogenol and zinc. To date, we’ve been limited to exogenous antioxidants as a way to increase the rate at which our body wards off oxidation. They are not, however, our first line of defense. At birth, each and every one of us is equipped with three primary endogenous enzymatic antioxidants; SOD (Superoxide Dismutase), Glutathione Peroxidase (GPx) and Catalase.
While both types of antioxidants are beneficial, we’ve become reliant on those from the diet to compensate for our inability to boost the effectiveness of our 3 primary antioxidants. For years, researchers have been examining ways to enhance the activity of our built-in bodyguards. One in particular, Superoxide Dismutase (SOD) has been of foremost interest. SOD targets what many researchers regard as one of our greatest health threats and aging accelerators - Superoxide radicals. These highly reactive, merciless molecules incite enormous amounts of oxidative stress and are capable of wreaking havoc on healthy cells. When cells are left unprotected by SOD, the results can be disastrous - respiratory problems, premature aging, memory loss, cardiovascular challenges, vision failure and joint structure damage, among others.
Until now, we’ve been at the mercy of our natural SOD reserves to fight superoxides. Researchers have been working feverishly to produce an effective oral SOD supplement, but have continually encountered a frustrating hurdle - exposure to gastric acid denatures SOD, rendering it useless. As a result, the only effective way to supplement SOD was through injections. These, however, only yielded short-term spikes. And then something remarkable happened that changed everything. Nutrition scientists in France determined that by combining Cucumus melo (a melon high in SOD) with a wheat gliadin stabilizer, it would be possible to prevent SOD from deteriorating in the digestive tract, while preserving it in the blood for extended periods. Not only is this the answer to a puzzle that has plagued researchers, it’s a breakthrough that will impact the life of anyone seeking longevity and vitality.
As the first proven oral SOD supplement ever introduced to the public, GliSODin® has taken antioxidant protection, immune support and antiaging science to an entirely new level. The primary function of GliSODin® is to scour the body for superoxide radicals and reduce them to less reactive ions that can be swept away; a process known as dismutation. In addition, GliSODin® reduces the oxidation vulnerability of healthy cells, protects mitochondrial activity and safeguards DNA structure.
What’s most remarkable is that GliSODin® has actually been shown to stimulate the body’s own natural production of all three enzymatic antioxidants, including SOD. For the first time in history, we will have the ability to enhance the effectiveness of our body’s primary defense mechanism.
New GliSODin® from NOW® represents the ultimate in antioxidant protection. By increasing one’s level of SOD while stimulating the natural production of Glutathione Peroxidase and Catalase, GliSODin® delivers antioxidant protection unlike any previously released dietary supplement. Remember, the aging process begins at a level that we simply can not see, the cellular level. Shielding your cells from superoxide damage is one of the smartest steps you can take against aging before your due time. GliSODin® has made this a reality.
AHCC® Fact Sheet - from Now Foods.
December 08, 2005 10:20 AM
AHCC® Fact SheetNeil E. Levin, CCN, DANLA 6/30/05
LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity.
KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound)
MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function.
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product.
AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system.
This formula is suitable for vegetarians and is offered in Vcaps.
SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach.
COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6),
PRODUCT SPECIFIC: None
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.
DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496.
Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315.
Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.
Vitaberry Plus + Super Fruit Antioxidant
December 07, 2005 05:43 PM
Vitaberry Plus +™ Super Fruit AntioxidantBy Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),
- Catalase (neutralizes peroxides),
- Functions similar to reduced Glutathione (GSH),
- Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent),
- Functions similar to Glutathione S-transferase (GST),
- Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
The Refreshing Feeling of All Things New
December 05, 2005 07:07 PM
The Refreshing Feeling of All Things New.
Springtime! We realize it's time to open the windows and let the fresh air in once again after a season of having everything shut up tight. More time spent indoors through the winter can mean months of recireculated air, less time spent outside, and overindulgence in holiday food. That's a recipe for toxic build-up. As you start to think about spring cleaning you will do inside your house, don't forget about the cleansing that is good for the mind and body. Decker Weiss, NMD To cleanse and detoxify the whole body, rely on Enzymatic Therapy's Whole Body Cleanse†. The National Cancer Institute recommends eating 20 to 35 grams of fiber a day, yet most Americans get only 15 grams. It's clear the right amount and the right type of fiber can make a real difference in cleansing our system and maintaining regularity day by day.† Taking Whole Body Cleanse for thorough periodic detoxification and Fiber Fusion to tone and renew your system on a daily basis is a great way to greet Spring.†
A Time for Rejuvenation.
Every day we are exposed to toxins in our food, water, and the air we breathe. The natural variation in volume and variety of today's environmental contaminants is a challenge for your body's built-in detoxification systems. Toxins Come from Many Sources: Foods that may have been exposed to pesticides, herbicides and fertilizers.
Hormones used in raising livestock.
The burning of fossil fuels in automobiles and utility power plants which can affect air quality.
Treated wastewater that flows into rivers, lakes and streams which can contain unwanted pollutants.
Whole Body Cleanse† and Simple Cleanse † from Enzymatic Therapy handle the environmental toxins you take in from the environment (like pollutants) as well as toxins that you make yourself (like free radicals), without depleting your body's store of beneficial nutrients.† Which on is right for me?
October 06, 2005 10:08 PM
Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance .
Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium . An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake . Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.
An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" . The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups . Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium .
In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body . It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys .
Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium . Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.
Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 . The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.
Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.
Magnesium-the Versatile Mineral
The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."
Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP . ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".
Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles .
Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat . Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress . This has been found true even in the absence of an actual magnesium deficit in the body.
Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density . The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men . In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency . While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.
Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes .
A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.
Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption . Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide .
Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 .
Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® .
Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)
August 02, 2005 03:52 PM
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.4
Thiamine and its Co-enzyme, TPP
Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.
Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites.
As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.5 In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves.
Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose.6 To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.6
Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs).
AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food.7 At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated.8 It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs.9 Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin.10 Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter.
Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage.11
Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.3,12 The statements in this fact sheet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Bitsch R, Wolf M, Möller J. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab 1991;35(2):292-6.
2. Schreeb KH, Freudenthaler S, Vormfelde SV, et al. Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. Eur J Clin Pharmacol 1997; 52(4):319-20.
3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther 1996;34(2):47-50.
4. Frank T, Bitsch R, Maiwald J, Stein G. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Eur J Clin Pharmacol. 2000;56(3):251-7.
5. Pike RL, Brown ML. Nutrition, An Integrated Approach, 3rd Ed. New York:MacMillan; 1986:467.
6. Hammes H-P, Du X, Edlestein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic neuropathy. Nat Med 2003;9(3):294-99.
7. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci 1984;81(2):583-7.
8. Brownlee M. The pathological implications of protein glycation. Clin Invest Med 1995;18(4):275-81.
9. Pomero F, Molinar Min A, La Selva M, et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol 2001;38(3):135-8.
10. Stracke H, Hammes HP, Werkman D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 2001;109(6):300-6.
11. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 2003;52(8):2110-20.
12. Bergfeld R, MatsumaraT, Du X, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia induced mitochondrial overproduction of reactive oxygen specifies and experimental diabetic neuropathy (Abstract) Diabetologia 2001; 44(Suppl1):A39.
Best Mangosteen 10% Extract with xanthone flavonoids
July 27, 2005 11:31 AM
• Defends Against Free Radicals*
The xanthone flavonoids and other compounds in mangosteen fruit are responsible for its high level of antioxidant activity. In vitro tests have been conducted on XanoMax? mangosteen 10% extract to determine the level of free radical scavenging ability in both watery and fatty environments. A major test recognized as the industry standard for measuring antioxidant activity is known as the ORAC (Oxygen Radical Absorbance Capacity) assay.
The ORAC test is an in vitro assay that works by measuring the amount of free radical damage done to a fluorescent probe (measured by a change in probe intensity). Antioxidants lessen the damage to the probe fluorescence, which indicates a reduction in free radical damage. This measure is used to quantify the antioxidant’s (or combination of antioxidants) capacity to quench free radicals. This quantification is known as the total ORAC value. The total ORAC value provides a relative measure of total antioxidant strength of any substance, allowing for comparison of different mixtures. A high ORAC value corresponds to a high total in vitro antioxidant capacity.
The development of the ORAC test has led to a number of commonly eaten foods being assessed in terms of total ORAC scores per serving. Similarly, particular combinations of antioxidants, such as those in nutritional formulas, can also be assessed for their total ORAC scores. This has led to the ability to determine the potential usefulness of a particular supplement in increasing overall antioxidant capacity.
When XanoMax? mangosteen 10% extract was tested for ORAC value, the resulting antioxidant potential was over 3,500 ORAC units per gram of extract. This result is extremely high. ORAC values of compounds vary with their nutrient concentration, moisture content and other factors. For comparison purposes, whole blueberries, considered to be a rich source of antioxidants, had an ORAC value of 61 units per gram, while pomegranate tested at 105 ORAC units per gram.1 XanoMax? mangosteen extract is a potentially rich source of beneficial antioxidants*
• Maintains Healthy Immune Function*
Evidence from several animal and in vitro studies on various cell lines suggests that components of mangosteen fruit extract may play a role in modulating several factors important to healthy immune function. Of the active components, xanthone derivatives seem to play the major role in influencing parameters of immune function in animals and in vitro models. Mangostin is the xanthone derivative that most of these studies have focused on.
A study published in 2002 assessed the effects of mangosteen extracts on the release of histamine from rat cell lines. The comparison was made to extracts of a plant frequently used in Japan, Rubus suavissimus, which is a known inhibitor of IgE-mediated histamine release from these cells. The assay showed that the mangosteen extracts used inhibited the release of histamine from these cells more potently than the extract of Rubus suavissimus. In addition, the authors compared the two herbs for prostaglandin E2 synthesis in another rat cell line and found that the mangosteen extract potently inhibited prostaglandin E2 synthesis in this in vitro trial, whereas the other herb had no effect.2
An earlier study was performed in guinea pig tracheal and rabbit thoracic aortal tissue. In this study, alpha mangostin prevented histamine-induced contraction and was shown to be a competitive histamine receptor antagonist in the smooth muscle tissue of the trachea and aorta of the animals selected. The results seen in this laboratory study were determined to be concentration-dependent. The authors suggested that alpha mangostin should undergo further studies to determine its effects on the modulation of the histamine response.3
Further in vitro assessments point to potential actions of mangosteen components in modulating effectors of occasional inflammation in the immune system. Studies in rat glioma cells suggest that mangostins inhibit enzymatic reactions that can lead to the production of specific prostaglandins.4,5 By inhibiting these reactions, mangostins may play a role in modulating overall immune function, promoting healthy immunity.
Mangosteen and its constituents hold much promise for their potential ability to enhance immune function and promote health. In addition to being a highly nutritious food, mangosteen extract is full of antioxidant activity. It has an extremely high ORAC value and a great potential for enhancing free radical defenses in the body. Best Mangosteen 10% extract contains XanoMax ™, which is standardized to a high level of active mangostin, the class of compounds shown in in vitro studies to benefit certain aspects of immune function. Safety Scientific References
ANTIVIRAL PROPERTIES OF ST. JOHN'S WORT
July 15, 2005 09:25 AM
ANTIVIRAL PROPERTIES OF ST. JOHN'S WORT
As stated previously, hypericin has recently gained much of the medical world’s respect as an antiviral agent, with activity against a broad range of enveloped viruses and retroviruses. The effective virucidal activity emanates from a com-bination of photodynamic and lipophilic properties. A recent article in the journal Transfusion details exactly how hypericin works in inhibiting viral activity among cells:
Hypericin binds cell membranes (and, by inference, virus membranes) and crosslinks virus capsid proteins. This action results in a loss of infectivity and an inability to retrieve the reverse transcriptase enzymatic activity from the virion.14 Another recent study, carried out in 1991, focused on hypericin’s ability to inhibit virus activity, more specifically, in the murine cytomegalovirus (MCMV), Sindbis virus, and human immunodeficiency virus type 1 (HIV-1). The Sindbis virus was significantly more sensitive than the MCMV virus. The inactivated MCMV, when used to infect cells, was incapable of synthesizing early or late viral antigens. In addition to the direct virucidal effect, when hypericin was added to cells infected with viable MCMV, inhibition was also observed, particularly when the compound was added in the first two hours of infection. The researchers also indicated that the effect was aided significantly by visible light, pointing again to the plant’s photodynamic property.
The study states that hypericin appears to have two modes of antiviral activity: “. . . one directed at the virions, possibly on membrane components, and the other directed at virusinfected cells. Both activities are substantially enhanced by light.”15 And there are other viruses that fall under St. John’s wort’s antiviral blanket. Contemporary research points to the equine infectious anemia virus, the lentivirus, the Sindbid virus, the radiation leukemia virus, and most importantly, the human immunodeficiency virus (HIV).
HAWAIIAN NONI (Morinda citrifolia)
July 11, 2005 08:50 PM
In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.
The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.
Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.
Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.
ROOT AND ROOT BARK
Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.
Body Systems Targeted
The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.
Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.
Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .
NONI: ITS USE AND HISTORY
Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .
Wonder Herb of Island Folk Healers
Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.
Noni’s Medical Reputation
Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.
A Timely Reemer gence
Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.
TRADITIONAL USES OF NONI
Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15
decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI?
One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .
Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18
How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.
MODERN APPLICATIONS OF NONI
Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.
Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.
xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.
A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21
In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.
with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.
The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.
The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.
The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.
While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.
A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29
Skin Healing Agent
One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.
burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30
The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.
Complementary Agents of Noni
PrimaryApplications of Noni