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The nutritional content and health benefits of pecans and walnuts Darrell Miller 5/13/19
Marijuana found to lower blood flow to the brain: Study authorssuggest this may increase risk of dementia, but this effect also makes itmedicinally useful for epileptics Darrell Miller 5/10/19
Beta-alanine supplementation relieves fatigue, increases musclecarnosine Darrell Miller 5/2/19
The Differences Between Hemp Seed Oil and Hemp CBD Oil Darrell Miller 4/29/19
Adaptogens for a Stressful World Darrell Miller 8/16/17
Scientists stunned to learn that gut bacteria seem to have control over your moods and brain function Darrell Miller 7/13/17
Organic onions richer in flavonoids Darrell Miller 7/8/17
Olive Oil Can Help Preserve Memory And Prevent Alzheimer's Darrell Miller 6/24/17
13 Ways Marijuana Impacts Males And Females Differently Darrell Miller 3/25/17
What are heart failure, heart attack and cardiac arrest? Darrell Miller 2/14/17
Could Obesity Undermine Memory Training in Older Adults? Darrell Miller 2/1/17
Inherited taste perceptions may explain why some people eat too much salt Darrell Miller 11/30/16
How Hyaluronic Acid Benefits The Skin Darrell Miller 5/20/14
Natural Skin Care Products - Kukui Nut Oil Darrell Miller 5/17/14
The Best Diffuser Darrell Miller 5/3/14
Sea Buckthorn Oil Darrell Miller 4/24/14
The Benefits That We Can Get From Using Collagen Skin Creams Darrell Miller 3/18/14
Can Green Tea And Pomegranate cream Help The Skin? Darrell Miller 3/7/14
Difference between Vitamin B-12 Cobalamine Darrell Miller 1/6/14
What Is The Difference Between flaxseed oil and fish oil Darrell Miller 1/1/14
Health Benefits of Vitex Darrell Miller 12/20/13
Niacin And Niacinamide? Darrell Miller 11/18/12
What Is The Difference Between American Ginseng And Korean Ginseng? Darrell Miller 12/28/11
What Is The Difference Between Echinacea Angustifolia And Purpurea? Darrell Miller 12/18/11
What Are The Different Types Of Ginseng And What Is Ginseng Good For? Darrell Miller 12/16/11
Omega-3 Darrell Miller 7/8/09
Calcium, Magnesium And Vitamin D Darrell Miller 6/24/09
Vitamin C Darrell Miller 3/13/09
Flaxseed Oil Darrell Miller 12/23/08
Hyper-immune Egg Vs Colostrum Darrell Miller 9/23/08
Is Saw Palmetto's Safe? Darrell Miller 7/15/08
Weight Loss and Calories Darrell Miller 6/24/08
Oregano oil hi in Carvacrol Darrell Miller 4/25/08
Depression and Vitamins Darrell Miller 4/17/08
Ubiquinol Darrell Miller 10/24/07
Active Coenzyme Q10 Darrell Miller 7/7/07
Turmeric and Alzheimer’s Disease Darrell Miller 5/10/07
D-Ribose Powder Benefits! Darrell Miller 4/10/07
Peppermint Oil for IBS Darrell Miller 3/24/07
The Power Plant of the Amazon Darrell Miller 3/2/07
Q. What is cat’s claw? Darrell Miller 11/22/06
Enjoy Some Nuts Every Day Darrell Miller 11/3/06
Benefits of L-Carnitine Darrell Miller 2/12/06
Omega-3’s Fight Postpartum depression Darrell Miller 1/23/06
Your Cells Supercharge Your Cells Darrell Miller 12/20/05
What is cat’s claw? Darrell Miller 11/11/05
Definition of Green Tea. Darrell Miller 11/5/05
Your emotions, your thoughts may effect your health... Darrell Miller 8/9/05
Energizing Intimacy - The foundation of a loving relationship is built on communication Darrell Miller 7/27/05
WHAT EXACTLY IS PYCNOGENOL? Darrell Miller 7/13/05
Bio-Chelation Darrell Miller 6/29/05
CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness Darrell Miller 6/29/05
Ginseng Varieties Darrell Miller 6/25/05
STOMACH CANCER, GEOGRAPHY AND GARLIC Darrell Miller 6/25/05
CLA and Cows Darrell Miller 6/22/05
An Essential Fatty Acid Darrell Miller 6/22/05
Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplement Darrell Miller 6/21/05
Mushroom Miracales Darrell Miller 6/18/05
Truth in Labeling Darrell Miller 6/14/05
Recognizing the Signs: Roadmap to a Healthy Heart Darrell Miller 6/13/05
Homeopathic Essentials Darrell Miller 6/11/05
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Darrell Miller 6/9/05
Glycerylphosphorylcholine -- Supports Cognitive Function in AD ... Darrell Miller 5/24/05
KudZu, Treatment of alcohol dependence or alcohol abuse Darrell Miller 5/19/05
Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic Darrell Miller 5/18/05
Important Information for Allergy Sufferers Darrell Miller 5/13/05
Garlic Extract Modulation or Pulmonary Vascular Function: Darrell Miller 5/12/05
Garlic Consumption and Cancer Prevention... Darrell Miller 5/12/05
Under-Reported (and Underappreciated) Cholesterol control. Darrell Miller 5/12/05




The nutritional content and health benefits of pecans and walnuts
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Date: May 13, 2019 04:21 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The nutritional content and health benefits of pecans and walnuts





Walnuts and pecans are both healthy snacks with lots of benefits. Walnuts have more fat and more protein, while pecans have more fiber and more natural sugars. The fat in both pecans and walnuts consists predominantly of healthy fats like monounsaturated and polyunsaturated fatty acids, as well as omega-3s. Both pecans and walnuts are good for brain health and rich in antioxidants. Their polyphenols help to protect the brain, while their healthy fats help to safeguard the heart and prevent atherosclerosis.

Key Takeaways:

  • Pecans and walnuts might have differences in looks and taste, but they are very well regarded for their healthiness and great tastes.
  • When one takes a serving of walnuts, he discovers that it contains more calories than an equal serving of pecans and this extra energy is stored in fats.
  • The fats in walnuts are usually good fats which consist mostly of polyunsaturated and monounsaturated fatty acids, along with omega-3 fatty acids.

"Walnuts have the B vitamins choline and niacin, while pecans show tiny amounts of vitamin A."

Read more: https://www.naturalnews.com/2019-03-31-nutritional-content-and-health-benefits-of-pecans-and-walnuts.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6312)


Marijuana found to lower blood flow to the brain: Study authorssuggest this may increase risk of dementia, but this effect also makes itmedicinally useful for epileptics
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Date: May 10, 2019 02:17 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Marijuana found to lower blood flow to the brain: Study authorssuggest this may increase risk of dementia, but this effect also makes itmedicinally useful for epileptics





Scientific literature on how marijuana works on the body is rapidly expanding. Right now, there are a plethora of studies on how marijuana works on the human brain. Some studies have shown that it can be effective in treating disorders of the brain like epilepsy. Recent tests show that marijuana can increase the risk of dementia because it restricts the flow of blood to the brain. These brain areas are essential for memory development. The area most affected is the hippocampus which can result in Alzheimer’s if prolonged. The researchers for the study used single photo emission computed tomography (SPECT) to measure blood flow to the brain after taking marijuana and they reported that there were very low and abnormal blood flow levels observed. This is when compared with persons who did not take marijuana. 982 patients were selected from a wide variety of data sources that was available to the researchers concerning persons who previously used or were still using marijuana. The results of the study showed that persons taking marijuana were at a risk of dementia due to the low blood flow to their hippocampus.

Key Takeaways:

  • The author notes that the studies regarding the effect of marijuana is increasing and this is particularly so regarding its effect on the brain.
  • Some recent tests show that it can increase the risk of dementia when marijuana is taken because it reduces the blood flow to the brain.
  • When the researchers used single photon emission computer tomography to analyze blood flow to the brain they observed abnormally low flow to the brain with users of marijuana.

"Users were analyzed using a brain SPECT and by conducting mental concentration tests against a sample of 100 people who had not used marijuana to determine whether there were significant differences that arose between users and non-users of cannabis."

Read more: https://www.naturalnews.com/2019-04-19-marijuana-lowers-blood-flow-to-the-brain-may-be-useful-for-epileptics.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6304)


Beta-alanine supplementation relieves fatigue, increases musclecarnosine
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Date: May 02, 2019 03:37 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Beta-alanine supplementation relieves fatigue, increases musclecarnosine





It has been found in a study that supplementing with beta-alanine can increase muscle carnosine and relieve fatigue. The study was published in the journal Nutrition Research and the team looked at the effects of beta-alanine supplementation on performance, L-histidine, and muscle carnosine in both women and men. This confirms earlier studies that supplementing with beta-alanine increases muscle carnosine, therefore improving the capacity of the muscles to buffer during intense exercise. The research team emphasized their comparison on the differences between women and men, and recruited 26 men and women who were given a placebo or beta-alanine for 28 days. It was shown that beta-alanine really increased muscle carnosine but the differences between men and women were unclear.

Key Takeaways:

  • The University of Central Florida researchers have made a study and in the study they suggested that supplementing with beta-alanine can relieve fatigue.
  • The focus of the study that was published in the journal Nutrition Research was whether supplementing with beta-alanine has an effect on performance, muscle carnosine, and L-histidine.
  • Studies that were done earlier before this one has shown that supplementation with beta-alanine increases the intramuscular carnosine content and improves buffering capacity in intense exercises.

"The findings of the study suggested that supplementing with beta-alanine for 28 days can increase muscle carnosine and relieve fatigue in men and women, but did not reduce muscle L-histidine."

Read more: https://www.naturalnews.com/2019-03-19-beta-alanine-relieves-fatigue-increases-muscle-carnosine.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6246)


The Differences Between Hemp Seed Oil and Hemp CBD Oil
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Date: April 29, 2019 02:49 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Differences Between Hemp Seed Oil and Hemp CBD Oil





With the increasing popularity of legalizing marijuana and CBD, along with many sates’ hopes of doing so, it will be imperative for the general public to understand the differences between Hemp Seed Oil and CBD oil. Becky Garrison has compiled a short recap on why consumers need to pay attention to the letters CBD when shopping. Hemp as a general term is more focused on skin care routines, vitamin supplementation and household products, CBD would help more with medical ailments such as pain and anxiety.

Key Takeaways:

  • Hemp seed oil is pressed from the hemp plant's seeds, much like sunflower oil.
  • If you want high quality CBD, it is extracted from the flowers of female-only hemp plants.
  • Hemp seeds do have a number of nutritional benefits, such as omega-3 and omega-6 fatty acids and vitamins A and E.

"Due to this confusion in which "hemp seed oil" is often mistakenly called "hemp oil," consumers should check the label to ensure they are purchasing the correct product for their needs. If you're looking for CBD, hemp seed oil isn't what you want; and if you're looking for hemp-based products for their nutritional content, then you may be disappointed in a hemp oil CBD product."

Read more: https://www.civilized.life/articles/the-difference-between-hemp-seed-oil-and-hemp-cbd-oil/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6213)


Adaptogens for a Stressful World
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Date: August 16, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Adaptogens for a Stressful World





The hottest selling botanicals fall under the category of adaptogens. Business in this area is thriving very well. This could be due to the influence of two different consumer targets that are interested in it. The differences are in age mostly. Recently, curcumin has been one of the top selling nutritional ingredients in the United States of America. Curcumin is an anti inflammatory agent and it comes from the golden yellow turmeric plant. This is an important health benefit.

Key Takeaways:

  • Herbal substances which aid the body in fighting stress, called adaptogens, include maca, schisandra, eleuthero and ginseng.
  • Interestingly, the high demand for adaptogens springs from opposing needs, specifically buyers that are looking for more energy and those seeking a calming influence.
  • The energy-promoting virtues of some herbs was highlighted in the 70s, when Russian cosmonauts and athletes began using them.

"In recent years, curcumin (Curcuma longa) has been among the top-selling nutritional ingredients in the U.S. market."

Read more: https://www.naturalproductsinsider.com/articles/2017/07/adaptogens-for-a-stressful-world.aspx

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Scientists stunned to learn that gut bacteria seem to have control over your moods and brain function
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Date: July 13, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Scientists stunned to learn that gut bacteria seem to have control over your moods and brain function





A team of researchers from the University of California, Los Angeles have found a link between their female subjects' gut bacteria and higher levels of anxiety, irritability, and distress. Subjects whose fecal matter contained the bacteria strain Prevotella displayed an increased number of neural connections linked to emotional, attention, and sensory brain regions. The findings of this study may help explain why individuals with irritable bowel syndrome and functional bowel problems are more prone to developing depression and anxiety.

Key Takeaways:

  • Scientists have now proven a link between gut microbes and emotions in humans
  • Researchers from the University of California, Los Angeles observed 40 healthy women and attempted to identify brain and behavioral characteristics based on their gut microbiota profiles.
  • These results support the age-old assumption that there is a connection between gut microbes and emotional response.

"This is the first time that behavioral and neurobiological differences associated with microbial composition have been studied in this way."

Read more: http://www.naturalnews.com/2017-07-10-scientists-stunned-to-learn-that-gut-bacteria-seem-to-have-control-over-your-moods-and-brain-function.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4963)


Organic onions richer in flavonoids
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Date: July 08, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Organic onions richer in flavonoids





Many studies have tried and failed to successfully prove whether organically grown foods are truly healthier then conventionally grown produce. A six year long study showed that onions grown organically consistently have ten to fifty percent more flavonoids then the conventionally grown onions, however, the difference in the amounts of flavoniods could have been caused by diffences in soil type, pest control or many other variables. Although higher in flavonoids, the studies still are inconclusive whether the higher amount makes the organically grown produce healthier then conventionally grown onions.

Key Takeaways:

  • The team’s analysis attributed the flavonoid content increase in the organic onions primarily to the differences in soil management and pest control practices
  • Rai points out that the study’s findings align with a major 2012 meta-analysis that found no nutritional differences between organic and conventional produce
  • Pinning down whether the increase translates to real health benefits is difficult, however. “That’s the million-dollar question,” says Rai. Thunder Jalili, a nutritional scientist

"Consistently higher levels of individual flavonoids were also present in the organic onions, and the extracts had higher antioxidant activity in two assays that measure radical scavenging activity."

Read more: http://cen.acs.org/articles/95/web/2017/06/Organic-onions-richer-flavonoids.html

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Olive Oil Can Help Preserve Memory And Prevent Alzheimer's
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Date: June 24, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Olive Oil Can Help Preserve Memory And Prevent Alzheimer's





Alzheimer's disease affects nearly 44 million people worldwide. According to a study done by researchers at Temple University in Pennsylvania, olive oil can help preserve memory and essentially prevent Alzheimer's disease. Dominico Pratico, lead researcher of the study, stated that olive oil helps reduce inflammation and activates a process in the brain called autophagy. Autophagy is a way that the cells in the body break down and clean out unwanted debris in the body. Mice were given olive oil in the study, and the mice that received the olive oil showed signs that the olive oil made their memory improve and lessened the signs of Alzheimer's. The researchers from this study plan to continue researching the effects of olive oil and Alzheimer's in older mice to see if they can eradicate the disease in mice altogether.

Key Takeaways:

  • Olive oil, a key ingredient of the Mediterranean diet and a healthier medium of cooking than regular oil can also preserve memory and prevent Alzheimer's disease, new study says.
  • The oil is a key ingredient of the Mediterranean diet, which is popular for a variety of health benefits, including a lower dementia risk
  • Adding extra-virgin olive oil is better than eating fruits and vegetables alone, and as a monounsaturated vegetable fat it is healthier than saturated animal fats.

"When the team studied the brain tissue from both groups of mice, they noticed "dramatic" differences in nerve cell appearance and function. As compared to the mice that didn't consume the oil, the brain cells of rodents in the oil group showed a dramatic increase in nerve cell autophagy activation."

Read more: http://doctor.ndtv.com/news/olive-oil-can-now-help-preserve-memory-and-prevent-alzheimers-1715610

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13 Ways Marijuana Impacts Males And Females Differently
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Date: March 25, 2017 08:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 13 Ways Marijuana Impacts Males And Females Differently





As legalization becomes more widespread in the United States, our understanding of the complexity of the effect of cannabinoid use is improving. A British pharmacology journal published a study in 2010 that examined sex related differences among marijuana users. For example, men tended to use more frequently, more heavily, and experience more often the binge food craving effect of weed. Women it seems may feel many of the physical effects more acutely then men. Genetics and hormones play a role in our health and behavior, and it appears they impact the effects of marijuana as well.

Key Takeaways:

  • The recreational use of marijuana is becoming more accepted socially and legally.
  • Marijuana may affect people differently depending on what their gender is.
  • The medical benefits of marijuana are real and it may someday replace opioids for the treatment of chronic pain.

"Regardless of how you feel about its use as a recreational substance, evidence is strong that marijuana has significant medical benefits for a wide array of conditions."

Read more: http://www.thealternativedaily.com/how-marijuana-impacts-males-and-females/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4284)


What are heart failure, heart attack and cardiac arrest?
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Date: February 14, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: What are heart failure, heart attack and cardiac arrest?





Though all types of heart trouble pose emergency threats to people's health, there are many Differences between them in terms of both causes and symptoms. "Heart failure" refers to some loss of the heart's successful function as a pump; "congestive heart failure" applies more specifically to when blood flow has backed up, causing the swelling of veins. A "heart attack" occurs when blood flow to the heart is cut off - sometimes, this is caused by a spasm. But if the heart suddenly stops beating, that is a "cardiac arrest", and is a problem with the timed electrical signals that make the heart contract.

Key Takeaways:

  • Singer George Michael passed away on Christmas Day, at age 53.
  • His manager, Michael Lippman, cited heart failure as the cause of death.
  • If Michael's heart not only failed but also stopped beating entirely, he would have had minutes for doctors to intervene.

"Blockages causing heart attacks are mostly caused by a buildup of plaque in the arteries."



Reference:

//www.cnn.com/2016/12/26/health/what-is-heart-failure-heart-attack-sudden-cardiac-arrest-explainer/index.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3940)


Could Obesity Undermine Memory Training in Older Adults?
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Date: February 01, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Could Obesity Undermine Memory Training in Older Adults?





According to a new study by Daniel Clark, obesity can alter your memory intake, especially in elderly people. They conducted a study of elderly people around 74 years old and watched them for 10 years, their results show that people with obesity have a lower memory function. The kicker is they can not find a direct correlation between the weight gain and the brain function activity. Looks as if their next study will be about how to keep weight off while losing weight and the effects.

Key Takeaways:

  • Memory training is far less effective in older adults who are obese than those who aren't, a new study finds.
  • Obese participants gained only one-third of the benefit of memory training compared with those who weren't obese, the study authors said.
  • However, the study didn't find any Differences by weight in the benefits from training in reasoning and problem-solving, or in thought-processing speed.

"Clark suggested that researchers need to focus on effective ways to prevent weight gain, as well as to lose weight."



Reference:

//www.medicinenet.com/script/main/art.asp?articlekey=201180

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3867)


Inherited taste perceptions may explain why some people eat too much salt
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Date: November 30, 2016 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Inherited taste perceptions may explain why some people eat too much salt





We all inherit genes of our family line, some of them are not ideal, but we deal with it. Many people have associated taste buds as being inherited, at least the this research studies believes so. We all have a different pallet some us like salt a bit more than others. But what if it was proved that you have inherited your taste perceptions, leading you to add more salt than recommended to your food, which would cause other medical complications.

Key Takeaways:

  • "Genetic factors that influence taste aren't necessarily obvious to people, but they can impact heart health by influencing the foods they select,"
  • In the current study, researchers sought to determine whether that bitter-enhancing genetic variations would also influence other food choices.
  • The study participants with the bitter-enhancing gene variants were no more likely to consume more than the recommended daily amounts of sugar saturated fats or alcohol, all of which can have a negative impact on heart health.

"Genetic Differences might help explain why some people like to use a lot of salt on their food."



Reference:

https://www.sciencedaily.com/releases/2016/11/161113160331.htm

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3538)


How Hyaluronic Acid Benefits The Skin
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Date: May 20, 2014 09:19 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Hyaluronic Acid Benefits The Skin

skinWhat is hyaluronic?

Hyaluronic corrosive is found in a great deal of hostile to maturing items. It helps your skin by enhancing the tone and composition. It is discovered characteristically in the body and serves to grease up specific territories.

Regularly Occurring

Your skin produces hyaluronic corrosive regularly. This happens in the deeper layers and keeps the skin stout and smooth. As we get more seasoned, our body thinks that it is hard to hold dampness so the skin starts to lose its tone and suppleness. Without sufficient dampness, the skin is inclined to hang and as it loses flexibility, wrinkles and scarcely discernible Differences show up.

Hyaluronic Acid's Function

This corrosive functions as  against maturing element by helping your body to transform collagen. Collagen is an exceptionally imperative connective tissue found in the skin, which helps it to keep its structure. Surveys Hydroxatone has indicated that including this as a segment the skin gets back its sound shine and energy.

Hyaluronic corrosive additionally helps the skin to repair itself from natural harm, for instance the climate or airborne poisons. Audits Hydroxatone has indicated that this cream works well in light of the fact that the Hyaluronic corrosive can infiltrate profound into the skin. Notwithstanding decreasing wrinkles, it has been indicated to support with skin aggravation and in lessening pimple inflamation scars.

Superior to Botox

There is other mainstream approaches to lessen wrinkles, for example, Botox or plastic surgery. Then again, the principle issue with these systems is, separated from being considerably more exorbitant; they are extremely equivocal on the body and can have awful reactions. Hyaluronic corrosive is not dangerous: it is even generated regularly by the body. It is much less expensive to utilize and has not been indicated to have any significant symptoms. Likewise, dissimilar to Botox infusions, creams holding this corrosive might be utilized anywhere on the face.

Hydration Properties

Hyaluronic corrosive can hydrate the skin successfully. Truth be told, it can hold 100 times its weight in water. One reason for wrinkles is skin dryness, so by holding more dampness in your skin, you can diminish the appearance of wrinkles as well as keep more from showing up.

Hyaluronic corrosive works successfully in against maturing. A substance discovered regularly in the body, it could infiltrate profound into the skin and serves to hold dampness. A cream holding this corrosive is a much more secure strategy than surgery and its belongings are longer enduring.

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Natural Skin Care Products - Kukui Nut Oil
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Date: May 17, 2014 01:52 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Natural Skin Care Products - Kukui Nut Oil

kukui nut treeWhat is kukui nut tree?

The Kukui Nut tree is a blooming tree that develops all around the tropics and was initially acquainted with Hawaii by right on time Polynesian pilgrims. On Hawaii, the tree immediately flourished is presently a national state symbol. The tree is occasionally alluded to as the Candlenut tree, Candleberry, Indian walnut tree and additionally the varnish tree. A few parts of the tree have the same number of employments, as the tree has been given names. The blossoms and bark are utilized within Hawaii to make the acclaimed Lei wreath and the tree trunk has utilized for 2 centuries now to make customary kayaks.

Generally, kids in Hawaii have been anointed with the kukui nut oil to secure them from the components and, likewise, the oil was found to have critical medicinal properties for skin disturbances, blazes, and wounds. The oil additionally has utilization as the premise for oil candles, henceforth where the names Candlenut and Candleberry are shaped. The scorched kukui nuts can likewise be utilized as the premise for tattoo ink and the oil is additionally utilized broadly as a part of Hawaii as a varnish and wood medications.

kukui productBenefits of kukui nut oil

In the nineteenth century, the tenants of Hawaii uncovered that applying the kukui oil to the skin helped ensure it from the sun and likewise recuperate the harming impacts of the sun, wind and salt water. Current clinical studies have discovered that Kukui Oil holds a few common fixings that give noteworthy characteristic profits to the skin. It gives a wellspring of a-linolenic corrosive, which helps the phone structure of the epidermis layer of the skin. The Kukui nut oil has been discovered to be exceptionally alleviating for gentle sunburn and is likewise demonstrated in giving easing from psoriasis and skin inflammation.

Also alleviating and recuperating, broke and dry skin, the kukui oil saturates, relaxes, and has been utilized for quite a while as a part of Hawaii to help revive dry skin and reduce the appearance of almost negligible Differences and wrinkles on the face. At the point when purchasing kukui nut oil skin health management items, search for items that are supplemented with Vitamins A, C and E and remember it that kukui does not give as defensive a sun boundary as cutting edge creams and salves so don't utilize these items for skin assurance, they are more for utilization as an after-sun medicine and lotion.

Other intriguing skin health management items leaving Hawaii are the lip mind demulcents, made up of a compound of Kukui Nut, beeswax, and Mango Butter and arrive in a reach of flavors, for example, sugar stick, coconut or simply unadulterated. A percentage of the unscented emollients can likewise obviously be utilized on dry noses, broke fingernail, skin, and mosquito chomps. At the point when purchasing kukui nut oil items it is fitting to watch that you are purchasing from a trustworthy merchant, ideally one situated in Hawaii who should have the capacity to give some insurance as to the degree of the genuine and nature of the oil.

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The Best Diffuser
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Date: May 03, 2014 04:45 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Best Diffuser

What is a diffuser

A diffuser can be defined as a flow of passage in wind tunnel that decelerates as a stream of gas or liquid from a place of high concentration to a place of low velocity. Diffuser works by breaking down essential oils into tiny molecules then directing them into the air to feel a place. As the oils are being broken down, they release natural ozone and they freshen and improve the quality of air. The particles stay in air for hours depending on how much oil is used and long the diffuser was on.

Different types of diffuser

Diffusers vary according to how they works. Different types of diffusers include ultrasonic, evaporative and nebulizer. Each has its purpose. But ultrasonic is a notch-higher than all of them. Having knowledge on Differences between them can help you make a good choice. Ultrasonic diffuser is mostly preferred for those who want smaller particles and higher lung absorption.

The ultrasonic is different from the rest because it does not need heat or an air pump to disperse the essential oils into the air. It performs its function by the use of a vibration from a disc that is found underneath of the oil reservoir. This disc vibrates at a high speed that makes the essential oil to break into micro invisible particles. Others like nebulizers will force the essential oil into the air in very larger particles, which ends up in saturating the air much faster.

Ultrasonic vibrations disperse the essential oils more conservatively. This will save you much money at the end and you are only going to use as much oil as necessary. This can also be useful if you only want to add a small amount of essential oil to your room. If you use nebulizers, you can easily over saturate your room, this can over whelm you, and it can lead you to an adverse response.

If you want a good diffuser that will give you a great and quality service, then you need to go for ultrasonic. It is very much affordable and it will give you value for your hard earned money.

Sources

  1. www. experience-essential-oils.com/ ultrasonic-diffuser.html
  2. www.essentialoildiffuser.org
     

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Sea Buckthorn Oil
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Date: April 24, 2014 05:18 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sea Buckthorn Oil

Ocean Buckthorn Oil

Sea BuckthornOcean Buckthorn Oil is concentrated from both seeds and the mash of the fruits of the Sea Buckthorn that is a prickly plant that develops in high amount in the highlands of the Himalayas-Karakoram-Hindukush locale including Pakistan. It is normally 2-4 meters in tallness with orange or red color berries weighing 0.20-0.35 grams.

This Oil is renowned for its uncommon mending properties, known from old times. The above said Oil is generally utilized within medication for the medicine and aversion of numerous infections. It is normally utilized as a part of nourishment, prescription and makeup.

This oil is normally utilized because of its taste and smell. It might be utilized as taste upgraded with greens, it could be utilized without anyone else present or might be blended with other vegetable oils. The said Oil could be utilized with any sort of sustenance, providing for them an extraordinary taste and expansion their wholesome worth.

The Sea Buckthorn Oil was likewise utilized as a part of the eating regimen of Russian cosmonauts and additionally as a cream for security from vast radiation. This Oil based games drinks "Shawikang" and "Jianibao" were the authority drinks for Chinese competitors tuning in the Seoul Olympic Games.

Benefits of berry oil

The Berry oil has a rich golden color, can stain our skin yet incidentally, and thus, must be utilized within the night. Due to its high cell reinforcement qualities, Berry Seed Oil makes for incredible skin molding and repairing. Recuperating smolders and other provocative skin conditions. The said Oil has likewise indicated effective change in skin pigmentation conditions, spot and rashly maturing skin. Truth be told, the Sea Buckthorn berry is second just to Rose Hip and Acerola in vitamin C substance.

Ocean Buckthorn Berry Oil has a rich staining color & a dissimilar emanation

The oil has a unique scent which isn't extremely engaging. Therefore, overall, it is not average oil regardless. The oil has served to diminish a portion of the scarce Differences around the eyes, it is immediately assimilated into the skin and doesn't leave characteristics

Because of its interesting plant and nutritious properties, and there has been no reported proof of ocean buckthorn oil bringing on hurtful responses or negative symptoms, the oil is additionally utilized as a regular executor that may profit numerous infections and dermatological maladies and skin conditions or oily stamps.

 

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The Benefits That We Can Get From Using Collagen Skin Creams
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Date: March 18, 2014 10:49 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Benefits That We Can Get From Using Collagen Skin Creams

Skin cream

It is safe to say that you are starting to perceive scarcely discernible Differences all over? Assuming that yes then now is the right time to act now before it gets most noticeably awful. It's fortunate that a couple of against maturing medications offer to improve the look of your face, neck and hands. One of the numerous options will be collagen skin cream. Might it be able to generate a change to your health or it is simply a plain trick?

What is collagen

Do you know what collagen is? And in addition what it can do on your epidermis? Adequately, it is one of the fundamental proteins and one of imperative establishments of your skin to help keep lines and different indications of maturing endlessly. More level levels of collagen and elastin are normally significant reasons setting off your skin to look wrinkled and listing.

As you develop more established, your physique won't produce as much of those two solid proteins like when you were adolescent. The skin drops flexibility, lists, and additionally becomes scarce making progressively more terrific facial lines. So in the event that you need to keep those things from happening, you have to raise collagen and elastin re-development goes by utilizing the best collagen skin creams.

Collagen skin creams that capacity ought to likewise hold an element called pragmatic keratin. Creams that have this element when connected topically can without much of a stretch pervade profoundly in your skin to energize your singular collagen and elastin to assemble once more.

Benefits of collagen

Observe that collagen skin creams ought to be clear of man-made additives notwithstanding included scents, essentially on the grounds that these are several purposes for touchy response. So rather than these fixings, it must have regular elements and cancer prevention agents like immaculate vitamin e which is an amazing fixing and it is helpful to skin's health. Numerous organizations dodge common kind essentially on the grounds that it takes more.

So recollect that the best creams to help collagen levels ought to be free of lethal aggravations alongside allergens. It ought not have an update that states like "end utilization if reactions show" don't buy that. There are a great deal more extraordinary items accessible available. There is no compelling reason to take a gander at extra hazard.

Collagen skin cream isn't simply a trick or trend, for it is a compelling system for minimizing barely recognizable Differences, wrinkles and different indications of maturing. Unquestionably the best and also sheltered method for boosting your cow-like collagen is utilizing a collagen skin cream with common parts loaded with age turning around profits.

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Can Green Tea And Pomegranate cream Help The Skin?
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Date: March 07, 2014 03:53 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Green Tea And Pomegranate cream Help The Skin?

What is pomegranate

pomegranate fruitPomegranate seed cream takes care of your skin from the outside and within. Pomegranate seed oil takes a shot at the outside to minimize the presence of lines and indications of maturing; inside, pomegranate seed oil is a dietary supplement rich in sound dietary fats and omega-3's. Regularly, an eating methodology rich in sound fats, vitamins, and hostile to oxidants gives skin the building squares it needs to look brilliant and adolescent.

The pomegranate has been in development for thousands of years. There is confirmation to help asserts that it has been in development since 3000 BC. And it has not gone unnoticed. The pomegranate appears in the Bible, in Egyptian tombs, and in eastern and western centerpieces.

Pomegranate on skin

Pomegranate seed cream animates the handling of collagen and the multiplication of skin units. Collagen is a vital structural protein that is available in the connective tissues of skin cells. As collagen breaks down, skin begins to look thin and dry and scarce Differences show up. Utilizing pomegranate seed oil as a major aspect of a saturating routine helps to modify collagen and fortifies skin units to process firm, young skin.

green tea leavesWhat is green tea

Green tea oil has numerous utilization, one of them being a skin mind item that offers some stunning profits, especially to tired, slack skin. You are dependably best to utilize characteristic items on your skin, on the grounds that large portions of the produced substance elements in advanced business skin mind planning can accomplish more mischief than great.

Numerous individuals wonder why characteristic items ought to be superior to uncommonly planned business synthetics that you can discover in your neighborhood store or drug store. One reason is that numerous business items hold savage chemicals, for example, surfactants and additives that can become scarce your skin and uproot its regular defensive oils. Green tea oil does neither of these things, yet delicately soothes tired skin without irritating the offset of your regular skin oils.

Many synthetics hold cleansers that are utilized as a part of cleaning up fluids and washing powders: might you rub cleaning up fluid into your face? Might you purify your physique with cleanser powder? Obviously not, however this is adequately what you are doing when you utilize some of these business "skin mind" items. And that is without actually saying the additives yet.

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Difference between Vitamin B-12 Cobalamine
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Date: January 06, 2014 01:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Difference between Vitamin B-12 Cobalamine

Vitamin B-12 occurs in many formations.

b12 foodsThe different formations of vitamin B-12, based on the functional group,is called cobalamine. The naturally occuring form in the human body is the dibencozide while the most common supplemented forms being the cyanocobalamine and methylcobalamine.

Differences between cyanocobalamine and methylcobalamine:

1. Cyanocobalamine has the presence cyanide ligand on the cobalamine and it is very stable and has a longer shelf live.Methylcobalamine, on the other hand, is an active cobalamine and has methyl ligand present in it.

2. Cyanocobalamine is converted into methylcobalamine in the body. The glutathione present in the human body removes the cyanide ligand and replaces it with methyl group. Cyanocobalamine is not recommended for persons who smoke as cyano group fails to detach in persons who intake tobacco. And hence the intake of cyanocobalamine can be fatal for smokers. It is also not recommended for those having liver failure since the glutathioneis formed in liver and hence if there is no glutathione the cyanide ligand cannot be detached and can pose threat to the body.4. At 1mcg dose cyanocobalamine is absorbed at 49.2% while methylcobalamine at 44.4%5. At 5 mcg dose cyanocobalamine is absorbed at 20.4% while methylcobalamine at 18.8%6. At 25 mcg cyanocobalamine is absorbed at 5.6% and methylcobalamine at 6.1% This indicates that cyanocobalamine is absorbed in the body better than methylcobalamine.The difference in the absorption can be attributed to the mass and the molecular structure of cyanocobalamine.Cyanocobalamine is cheaper than methylcobalamine and it has prolonged shelf life compared to other cobalamine forms. It appears as crystals synthesis and is red in color. Although the food rich in vitamin B-12 is enough for the body to meet the daily requirements, deficiency of this vitamin leads to disturbance in the sleep pattern, feeling of tingling in the body parts, numbness, etc

Reference:

  1. Comparison of vitamin B-12 forms by Michael Mooney/SuperNutrition October 2007

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What Is The Difference Between flaxseed oil and fish oil
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Date: January 01, 2014 07:03 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is The Difference Between flaxseed oil and fish oil

fish oilBefore you can compare flaxseed oil and fish oil

It is first important to understand the Differences between the two oils. Extracted from the dried seeds of the plant rips linen, flax seed oil is clean and almost yellow. The oil is obtained by a cold method or by solvent extraction. Flaxseed oil contains acid lineolic, a particular form of omega-3 fatty acids. Fish Oil is extracted from the tissues of fatty fish containing EPA, Docohsahexanoic acid (DHA) and eicosanoids.

Benefits of compare flaxseed oil and fish oil

Some of the health benefits are reducing inflammation. For comparison, it is essential to analyze the benefits of both oils. Two omega-3 fatty acids, EPA and DHA in this oil and are a great help in creating hormone-like substance that reduces inflammation and blood pressure. They have also been shown to reduce triglycerides and the accumulation of plaque in the arteries.Omega-3 oils promote the secretion of serotonin. Serotonin is a chemical anti-depressant produced by the body and thus reduces or mitigates the effects of depression. Fish oil is often used in the treatment of patients with HIV / AIDS, and has proven to be helpful in lowering triglyceride levels in the body that build up after prolonged use of antiretroviral drugs. This is extremely useful because it can reduce the risk of a patient for coronary artery disease. In addition to providing relief from chronic inflammation, they is also useful for those suffering from joint pain, such as rheumatoid arthritis. The EPA has also found that fish oil helps protect the skin from photo damage. Photo damage is known to cause permanent skin wrinkles and skin damage. In addition, some studies have shown that they may prevent schizophrenia, with minimal side effects. Mothers who take fish oil during pregnancy often bear children with enhanced brain function as well as children with higher IQs. They are also less prone to cognitive problems. And the effects of postpartum depression seem to lessen with the regular intake of fish oil.The fish oil supplements have even more benefits, including lower risk of macular degeneration in the aging process. And studies have shown that with weight training significant reduced pain is present in the bodybuilders who regularly consumed fish oil. Other benefits are providing relief for digestive diseases..

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Health Benefits of Vitex
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Date: December 20, 2013 09:04 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Health Benefits of Vitex

vitex flowerHealth Benefits of Vitex

Taken from a mediterrenian tree, vitex has numerous health benefits in human life especially to women. Taken as alternative medicine, the herb can affect human body in various ways leading to diverse health benefits.

These benefits include;

Menopause alleviation

Women who consume vitex have been found to have longer reproductive life due to delayed menopause. This results from prevention of the women from hot flashes, night sweats, vaginal dryness and weight gain- identified as common signs of menopause. If properly administered, the herb has in addition been found to reduce the effects of hormonal imbalance such as excessive bleeding during menstruation.

Fertility enhancement

Vitex is used to enhance fertility. Studies have established that the herb helps women with irregular periods and consequent irregular ovulation. This has been attributed to the herb's ability to facilitate estrogen regulation in the body as required during the first half of ovulation cycle while enhancing improved levels of progesterone required in maintaining pregnancy.

Maintains pregnancy

Research has established that the use of vitex during the first trimester reduces the chances of miscarriage. This has been established to be effective because the herb contains chemical substances necessary for enhancing and regulating hormonal balance in the body during pregnancy.

Alleviates Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is a set of unpleasant signs and symptoms experienced during menstruation. They include severe stomach and backaches, cramps, fatigue among others. Consumption of vitex has been found to alleviate these hormonal based complications. During menstruation, women often suffer hormonal imbalances which lead to Differences in their responses to issues as well as strained body and even pains at times. The use of vitex has been found to enhance hormonal stability leading to reduced effects of the disorders associated with hormonal imbalances.

Relieves breast pain

On consumption of vitex, it influences the pituitary glad to produce progesterone hormone leading to reduction in breast pains especially during breast feeding.

References:

  1. //www.herbs-for-menopause.com/vitex/vitex-benefits.htm
  2. //www.livestrong.com/article/95347-vitex-benefits
  3. //hethir.hubpages.com/hub/vitex


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Niacin And Niacinamide?
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Date: November 18, 2012 10:32 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Niacin And Niacinamide?

Niacin Vs Niacinamide

Niacin

Niacin also known as nicotinic acid is an organic compound and it is one of the essential human nutrients. Niacin deficiency can result to pellagra. It is also used for reducing cardiovascular issues. A chemist called Hugo Weidel first described niacin in 1873 in his studies of nicotine in the oxidation of nicotine using nitric acid. The name niacin was derived from nicotinic acid + vitamin.

Niacinamide

Niacinamide is also known as nicotinamide or nicotinic acid amide. It is the amide of niacin. Niacianamide is part of B-vitamin and it is water soluble. Niacinamide is derived from niacin. These two are components of B3-vitamin and they are often used as supplements interchangeably. However, there are some critical Differences between these two vitamin B3 components. Niacinamide is derived from niacin and the body is able to convert niacin into niacinamide.

Niacinamide can also be made by our body from an amino acid known as trytophan which is usually present in animal foods. A chemical compound known as an amide is what makes niacinamide. Amide is defined by a nitrogen atom which is combined with a carbonyl group or C=O. Therefore, the main distinction between these two components is that niacinamide is a derivative of niacin.

Different Pharmacological Properties

Although the two are used interchangeably, they have different pharmacological properties. Their physical effects on the body also differ and people who are sensitive to their effects may prefer to use one over the other. Their usefulness in treating different conditions for instance high cholesterol, circulatory problem and osteoarthritis can also differ. Because of the pharmacological properties difference in niacin and niacinamide, different people can have different physical reactions when they take one as opposed to the other.

High niacin doses can cause flushing a condition that causes blood vessels to widen. This makes the capillaries under the skin to expand to allow more blood to flow making the skin to become red and itchy. Niacinamide does not have the effect of skin flushing and that is why it is preferred over niacin in the treatment of pellagra, a condition that results due to lack of vitamin B3. The only affect that niacinamide may cause is excessive sweating.

Niacin And Cholesterol

Niacin on the other hand it is preferred in the treatment of high cholesterol levels while niacinamide is not preferred in this treatment. This is because since niacinamide is a derivative of niacin, the cholesterol lowering properties in niacinamide are inhibited. Niacin is also preferred in treating circulatory problems because of its effects on the blood vessels and the role it plays in lowering high cholesterol levels hence preventing hardening of the arteries.

This in addition reduces the risk of heart attacks. On the other hand, Niacinamide may also be preferred for treating osteoarthritis and diabetes. The two can be used in treating physical and emotional stress. Either niacin or niacinamide may be used for treating anxiety and depression. For these two components of Vitamin B3 to be effective, doctors recommend that they ought to be taken in combination with Vitamin B1, B2 and C.

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What Is The Difference Between American Ginseng And Korean Ginseng?
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Date: December 28, 2011 07:52 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is The Difference Between American Ginseng And Korean Ginseng?

Ginseng is a perennial plant which belongs to the genus of Panax, specifically in the family of Araliaceae. It is native in many places such as in North America and East Asia. It can also be abundantly found in other areas of the world which have a cool climate. Ginseng is a broad genus of plant. It has many subtypes in which plant description as well as health benefits may have similarities and Differences. Despite their variations, all ginseng plant contains the active ingredient which is called ginsenosides.

One type of ginseng is the Panax quinquefolius or commonly called American ginseng. Despite its name, this kind of ginseng is widely used in the Chinese traditional medicine. This kind of ginseng originated in Northern America. However, cultivation is more abundant in China. Like many other ginseng plant, this is a perennial herb which contains ginsenosides.

Another type of ginseng which is popularly used in many alternative medicines is the Korean ginseng, also known as Asian ginseng. This kind of ginseng has a similar chemical structure with American ginseng. Like the American ginseng, this kind of ginseng also has many health benefits to human body because of its ginsenosides content. The scientific name for Korean ginseng is Panax ginseng.

Clinical studies have revealed that American ginseng has been found to have an effect more on the immune system of the person. It effectively boosts the immune system thus protecting the body from harmful microorganisms which can cause diseases and infections. Other studies have shown that American ginseng can potentially have a therapeutic effect against inflammatory diseases. On the other hand, Korean ginseng is more on as a tonic herb. It significantly helps the nervous system relax and stabilize mood and behavior. In fact, ongoing studies are being conducted to help develop the brain and the other parts of the nervous system to its maximum.

Other Differences of the two beneficial ginseng plants are that American ginseng has a cooling effect therefore; it is best used during humid weather conditions. On the other hand, Korean ginseng is a little bit warm in nature. Hence, the latter is great in times of cool climates. Also, American ginseng is found to have a tranquilizing and sedative effect, while Korean ginseng has revitalizing and energizing properties.

Another difference is that, American ginseng is rich in a type of ginsenosides called Rb1 while Korean ginseng is abundant in Rg1 type of ginsenosides. The former is great for increasing the yin energy while the latter is effective in boosting the level of yang energy.

Ginseng herbs can be taken fresh. Many people prefer the roots while some like the leaves more. Nowadays, supplements are already formulated. It is available in the form of tablets, teas or extracts. Topical use is also common therefore ointments and creams are also manufactured. If you are planning to have ginseng supplements, it would be best that you should consult your doctor first. This would greatly help in the prevention of untoward effects of the supplement. Though ginseng is relatively safe, side effects may still occur. However, these effects are non – life threatening.

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What Is The Difference Between Echinacea Angustifolia And Purpurea?
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Date: December 18, 2011 08:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is The Difference Between Echinacea Angustifolia And Purpurea?

In the advent of natural medicine these days it is important for us to also know what we are dealing with. We may feel that it is better because it is all natural but still, just like prescription drugs, herbal medicine also has its attractiveness to those who want to take advantage of people’s needs and momentary lapses of judgement. It does not mean that it is all natural it is good for the body right away, we also need to find out if it is exactly what we need or what we expect it to be. These herbal medicines and supplements in the market today come from plants and they are derived from it by various types of processing. As an example, we can look at Echinacea Angustifolia And Purpurea and what the Differences are.

Echinacea

Both of them are species of this plant and we will only be able to understand more about those two if we are able to know their mother so to speak. It is a genus of herbaceous flowering plants and those two are part of the family and it has 7 other brothers and sisters so to speak because there are 9 species all in all including both the E Angustifolia and E. Purpurea. In modern natural medicine it has been known to have a lot of health benefits and the main one being its ability to support the immune system and help activate white blood cells to improve bodily functions. Other studies have learned that it has the ability to influence the increased production of interferon which is an essential part of the body’s defensive response to any viral attacks that may cause infections.

Echinacea Angustifolia

This flowering plant is believed by some to be a miracle plant especially in the natural medicine world. It has shown to have amazing healing powers and this is what makes it a popular part of alternative medicine. Throughout US history it has been used by native Americans and frontiersmen as tonic and somewhat of a cure all treatment for various ailments and rightfully so because in modern science it has been proven to have amazing antiviral and antifungal properties which makes it an effective treatment against infections, certain diseases, common colds and flu. Other uses that it may have are being a treatment for inflammation, skin ulcers and upper respiratory infection which needs more studies to be done but early results seem promising.

Echinacea Purpurea

This specie is not as popular as the other but it also can be effective. It basically is a perennial with long stems and long lasting lavender coloured flowers. It also has the power to help the immune system be stronger and is commonly made as a tea. Studies have shown that it has a mild natural antibiotic characteristic and its extracts has been known to have the ability to increase white blood cell count as well however it is helpful to note that it is better in smaller doses than in large ones.

Both forms posses the same properties primarily immune boosting properties; either one is good to use to help strengthen the body in times of cold and flu and disease.

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What Are The Different Types Of Ginseng And What Is Ginseng Good For?
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Date: December 16, 2011 06:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Different Types Of Ginseng And What Is Ginseng Good For?

Ginseng is a considered to be a perennial plant which is a member of the Panax genus under the family of Araliaceae. It is abundantly found in North America, East Asia and other places which have a cool climate. There are many types of ginseng. Though different in kind, all these species of ginseng contains the active ingredient known as ginsenosides. This chemical substance is the one responsible for the many health benefits of ginseng.

The types of Ginseng are:

1. PANAX GINSENG. This type of ginseng is also known as Asian ginseng. It is very rich in ginsenosides which proves that it is included among the types of true ginseng.

2. PANAX QUINQUEFOLIUS. This ginseng has an effective adaptogenic property. It is otherwise known as American ginseng. This herb is also considered as a true ginseng.

3. ELEUTHEROCOCCUS SENTICOSUS. The other name for this herb is Siberian ginseng. However, it is not considered as a true ginseng because it does not contain ginsenosides but eleutherosides. Also, ginseng has a fleshy root while this herb has a woody one. Despite their Differences, Siberian ginseng also has similar effects to true ginseng herbs. It has an adaptogenic property which can effectively improve the overall health of the individual.

As mentioned above, ginseng has many benefits to human health. These include:

1. IMMUNE SYSTEM BOOSTER. Ginseng contains several vitamins and minerals which can be helpful in improving the immune system as well as the overall health of the individual. Studies have shown that ginseng has an ample amount of Vitamin C which can help maintain the health and strength of the body’s immune system. As a result, ginseng can effectively improve health especially those who are one the recovery phase of an illness.

2. LOWERS BLOOD GLUCOSE. Asian ginseng is noted for its potential ability to help regulate blood sugar levels. This is made possible because of its action in the stomach and intestine to control the absorption of glucose from the diet. In this connection, health experts highly recommend that individuals under diabetic therapy must use ginseng with extra care because it might cause hypoglycemia or low level of sugar in the blood.

3. AFFECTS BLOOD PRESSURE. Ginseng can produce an effect to the blood pressure of the individual, either high or low blood pressure. Depending on the dosage and the person’s response, ginseng can effectively maintain blood pressure within it normal limits.

4. IMPROVES THE OVERALL STATE OF HEALTH. Many ginseng consumers have reported that they experience an increased sense of well – being with their regular use of such helpful herb. It is also commonly used for the improvement of one’s stamina and endurance in performing many mental and physical tasks.

Ginseng can be consumed raw. Others use dried roots of this herb. Supplements are also available in the form of tablets, extracts and teas. Ointments and creams are also formulated for topical administration. If you plan to use ginseng for a particular health indication, make sure to talk to your doctor first since ginseng can have significant effect to the body as mentioned above. This will greatly prevent adverse effects and interactions with other medications you are taking.

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Omega-3
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Date: July 08, 2009 10:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Omega-3

The headline "Doubts over heart claims of omega-3 fats" was published in March of 2006 in the world's largest international news agency, Reuters. This article reported on the findings of a study on omega-3 fats and heart health, which published the exact same month in the British Medical Journal. The article found in Reuters claimed that the systematic review of 89 studies led to the conclusion that there was no substantive evidence that omega-3 fats actually protected individuals against cardiovascular disease or cancer. The New Zealand Herald picked up this article and announced that the heart-healthy advice to eat more oily fish was incorrect, as it advised its readers to put fish oils on the top of the list of medical beliefs that turned out to be myths.

In actuality, the omega-3 investigation, conducted by Lee Hooper and coworkers at the University of East Anglia School of Medicine, was a meta-analysis, as it combined data from several available clinical trials. Meta-analyses are highly speculative due to the Differences in the scientific protocols between the included studies, which can lead to difficulty in exposing a common factor. A good meta-analysis is often useful to put contradictory evidence into perspective. However, a poorly designed analysis can lead to bad science and faulty conclusions.

This Hooper analysis was a review of 48 randomized controlled trials, along with 41 cohort studies. However, the investigation only used as few as 15 controlled trials and 3 cohort studies in compiling the data. Included in this analysis were studies that had very small sample sizes and provided little data on the effects under investigation. Extremely low death rates in several of the studies that were included worsened the situation, which resulted in a very large confidence interval and a lower analytical power than what was expected. Additionally, there was a large degree of difference among the included studies. Some of them had death rates in their control groups as low as 0.5%, while others had extremely high control-group death rates exceeding 15% and 22% in two cases. This fact indicates that there were large disparities in the health of subjects. This much heterogeneity among subjects requires a high degree of analytical power in order to produce meaningful results. This was something that the Hooper study lacked.

When addressing the above issues, the authors of the study pointed out that “there were too few events such as deaths, associated cardiovascular events, and incidences of cancer to rule out the possibility of important effects from various interventions.” This basically means that the numbers produced in the study produced results that didn't show much of anything. In a case like this, a person should be extremely cautious as to dismissing a possibly association based on negative results. Dr. Mike Knapton, the Director of Prevention and Care for the British Heart Foundation cautioned the public that they should not stop consuming omega-3 fats or eating oily fish as a result of this study. The wise advice given by Dr. Knapton, however, was not enough to stop the media from fabricating stories and devaluing the necessity for omega-3 fats.

The fact is that omega-3 when taken on a consistent basis can help reduce cholesterol and improve cardiovascular health. Look for high quality omega-3 fish oil that is molecularly distilled at your local or internet health food store. Always select name brands to ensure quality and purity of the product you purchase.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Omega-3 fish oil is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

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Calcium, Magnesium And Vitamin D
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Date: June 24, 2009 12:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Calcium, Magnesium And Vitamin D

In February 2006, the findings of an $18 million double-blind placebo-controlled study were published in the New England Journal of Medicine. This study was conducted by the Women’s Health Initiative (WHI) and was on the protective effect of calcium and vitamin D. The New York Times reported on this study, declaring that the study found that there were no clear benefits to calcium pills. In this article, the fact that the women who stuck to their supplementation regime experienced 29% reduction in hip fractures was dismissed. This result is rarely achieved, even with use of the strongest pharmaceuticals.

This study was designed to determine whether postmenopausal women who were given calcium and vitamin D would have a lower risk of hip fracture. The intervention group was given 1,000 mg each day of calcium carbonate, along with 400 IU of vitamin D. Although these women portrayed a greater preservation of hipbone density, the decrease in risk of fracture of 12% was not significant as a whole. The fact that many of the women who were included in the study were under sixty, and therefore, not typically at risk for fractures, causes these results to be unsurprising.

The results that were found were also skewed as a result of the fact that compliance with the prescribed daily intake was only 59% by the end of the study. 41% of the study participants had fully stopped taking the prescribed daily dosage of calcium and vitamin D, with 24% having discontinued the supplementation altogether. With such an unexpectedly low compliance rate, along with the fact that the projected hip fracture rate was over twice what was actually observed, the power of the study was reduce to only 48%. As a result, the trial had less chance than a simple flip of a coin to find anything but the largest of Differences in a risk for fracture.

Despite these shortcomings, the researchers looked at the subgroups, and found different pictures emerging. Looking only at the women who mostly stuck to their prescribed regime, researchers found that a reduction in fractures of 29% was experienced. Additionally, those women over sixty experienced a reduction in the risk of fracture of 21%. These results are actually remarkable, especially after considering the many problems which clouded the accuracy of the data. Unfortunately, reporters did not look at these findings, causing a slanted account of the study to be published. Because of this, the media failed to acknowledge what were actually significant findings.

Additionally, the design of the WHI study disregarded the fact that a reduction of fracture risk is actually dependent on several factors other than calcium. Studies have actually shown that magnesium is also of equal important in the treatment and prevention of osteoporosis, as a deficiency plays a central role in the development of the disease. Postmenopausal women and those women with osteoporosis usually have low bone-magnesium content, exhibiting other indicators of magnesium deficiency that are not seen in non-osteoporotic women. Also, calcium competes for absorption with magnesium, meaning that postmenopausal women who increase calcium intake without also increasing magnesium intake can impair their absorption of magnesium. With this knowledge, the failure of the researchers to include magnesium supplementation along with calcium and vitamin D caused the potential for a study that could cause harm on the patients. With the results as they are how can we trust studies that are conducted when the patients who participate do not follow the rules? For those who want to prevent osteoporosis, calcium, magnesium, and vitamin D when taken together can help slow and prevent the onset of brittle bones.

Calcium, magnesium, and vitamin D come in capsule, tablet, and liquid softgel forms at your local or internet health food store. Always look for a name brand calcium, magnesium, and vitamin D supplement to ensure quality and purity of the product you purchase.

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Vitamin C
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Date: March 13, 2009 02:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin C

The coming of winter brings the possibility of becoming sick for many people. Millions of Americans suffer from at least one bout of the flu or cold each year, which results in millions of hours of lost work time, millions of dollars spent on remedy products, and flat-out despair. Those people who do come down with a cold or flu end up seeking out syrups, lozenges, tablets, and pills that are not designed to get rid of the ailment, but suppress its various symptoms instead.

There has been no cure to date for the various strains of viruses that cause colds and flu. Although conventional medicine has attempted to suppress the symptoms of the flu and cold, most of the products are relatively ineffective and come along with a variety of side effects. Thankfully, there are natural methods and products that help to prevent infection from cold and flu viruses and also help to shorten the duration and lessen the severity of a cold/flu infection.

The Differences between a cold and flu are often imperceptible. However, there are several Differences. Although there are more than 20 identified major virus families, most colds come from only five of these. Three other virus families produce flu, which are usually identified as A, B, and C strains. Flu types B and C are generally mild in adults, both of which are often confused as bad colds. Once a person experiences a type C flu, they usually gain immunity, although children can get it more than once. The type A flu virus is the least stable and most volatile, as it changes genetic makeup frequently. Type A strains cause more severe symptoms than a cold and individuals do not generally develop an immunity to it. The virus found in the type A flu are generally the viruses that produce epidemics.

The flu is almost always more severe than a cold, as it is usually accompanied by fever, chills, and aches. The onset of a flu is also much more rapid than that of a cold, with a flu usually lasting anywhere from a few days to a week. However, residual effects from the flu can last up to a few weeks.

Most colds come from one of five virus families, with almost half coming from the rhinovirus family. The rhinovirus wasn’t officially detected until the late 1980s. Colds are usually restricted to the nose, throat, and surrounding air passages and usually do not bring fever, chills, or the more severe symptoms that often associated with the flu. Unfortunately, the duration of symptoms of a cold is usually longer than that of the flu, as it sometimes lasts several weeks at a time.

Viruses are the cause of the majority of symptoms that are found along with a cold or flu. They are involved in the cause of these symptoms in several ways. First of all, some of the symptoms of a cold are caused by the body’s own response to the infection. Some of these symptoms include cough, fever, runny nose, sneezing, and watery eyes. Viruses often prompt what is termed a disease process, in which antibodies are produced that attach to the viruses they’re fighting as both travel throughout the body.

The virus is able to destroy or damage vital organs that they invade. Depending on the extent of the infection in the organs, along with the overall virus invasion, the body’s immune system can be worn down, which makes it much more susceptible to other infections. Fortunately, natures provides relief. Those who suffer from the flu or a cold can take vitamin C which has been shown to reduce the severity and length of ones cold.

Year after year the flu will rear its butt and there is little we can do accept keep clean by washing our hands regularly. Even though the flu can not be stopped, vitamins like vitamin C can help reduce the length and severity the cold one experiences. Quality vitamin C is inexpensive and available at your local or internet health food store.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamin C is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.



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Flaxseed Oil
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Date: December 23, 2008 11:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Flaxseed Oil

Although it is important to stress that the fatty acids found in flax are essential, flax also contains substances called lignans. Lignans are special compounds that demonstrate impressive health benefits, as they seem to be responsible for assisting the immune system in many ways, along with helping to prevent some types of cancers.

Because flax contains lignans, it is an even more beneficial to the body when consumed in this form. Flax is one of the most abundant sources of lignans, a type of phytoestrogen that interferes with estrogen metabolism in animals and humans. This property gives lignans the ability to help in the prevention of both fat and hormone-sensitive types of cancer. Lignans also benefit the body by providing antibacterial, antifungal, and antiviral activity that helps the immune system to function optimally.

All of the benefits of flax are still yet to be known, but it has been established that flax is also a good source of fiber. There have been several studies which confirm that flaxseed can be a cholesterol-lowering agent similar to oat bran, fruit pectin, and other food ingredients that contain fiber. Because flax packages both omega-3 fatty acids and soluble fiber together, it presents two ingredients which provide healthy blood lipid patterns. Flaxseed contains beneficial amounts of both soluble and insoluble fiber, giving it potential cancer-fighting ability especially in colon cancer.

When selecting a healthy diet, it is important to consider your sources of essential fatty acids. Essential fatty acids are fragile and easily damaged by air, high temperatures, and food processing, so you are unlikely to get all of the EFAs that you need, even if you are careful to use vegetable oils for cooking. Most of the oil that we consume today has been heavily processed, which damages essential fatty acids. When choosing flax oil, you’ll want to take into account the same considerations, looking for oil that has not been damaged by processing and is packaged to block all light from contact with the oil.

Not all flax oils are the same, with there being a great deal of variation in quality and purity as a result in Differences of how the oil is expressed. Most flaxseed oils are mechanically pressed out through an expeller, in which great amounts of heat and pressure can be generated. The higher the temperature, the better the yield of oil, but the lower the quality of oil. Many manufactures willingly sacrifice quality for quantity. The best way to measure the quality of oil is by taste, with the degree of bitterness being a close approximation of the level of lipid peroxides. The best source of high quality flaxseed oil can be found in health food stores where inventory turnover is highest.

Some good guidelines to go by in selecting a good flaxseed oil include: making sure the flaxseed oil is derived from 100% certified organic flaxseed; making sure the oil is as fresh as possible and not past the expiration date; making sure that the oil is expeller-pressed or cold pressed; using flaxseed oil that is high in lignans to gain the most benefit.



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Hyper-immune Egg Vs Colostrum
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Date: September 23, 2008 03:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Hyper-immune Egg Vs Colostrum

When a hen lays her eggs she is virtually an antibody-producing factory, as she passively transfers her antibodies and immunoregulatory factors into the egg in order to protect her offspring. These eggs are made up of a concentrated source of antibodies and helpful immune-supporting biomolecules. However, there are significant Differences in the way a cow passes immune protection to a calf and the way a mother hen passes protection to a chick.

A newborn calf will nurse for several months, acquiring immune support over the entire period of time. Since a mother hen cannot nurse her chick, it is essential for the egg to provide all the immune support a chick will need until its own immune system is functioning properly. Because of this, an egg is much more concentrated in antibodies and immunoregulatory molecules than is colostrums. This is an advantage for using hyperimmune egg over supplements that are made from bovine colostrums as an immune system support. It has been found that chickens produce almost twenty times more antibody per unit of weight than cows are able to secret in their milk. Additionally, certain egg antibodies are compared to milk antibodies, and it has been found that egg antibodies seem to be more effective in binding antigens.

In order to produce a hyperimmune egg supplement, the following procedure must be followed. First, eggs are collected from the specially designated chicken flocks after they are specifically stimulated. They are then washed and broken. The yoke of the egg white is then removed and dried to produce a find proteinous powder. There have been various processes developed to minimize the amount of heat damage to antibodies and immunoregualtory factors during the spray-drying procedure. The immune eggs are required to be processed under good manufacturing practices in USDA-inspected and monitored facilities. After processing occurs, the powders are combined with other vitamins, minerals, and possibly other ingredients in order to form a formula that possesses a high nutritive value.

Unlike the conventional methodologies, hyperimmune eggs seems to team up with our immune system instead of boosting or suppressing its function. The immune products in hyperimmune egg are a resource for the body. The body is then able to select those immune elements that it needs in order to up or down-regulate the autoimmune and inflammatory pathways.

Because our immune systems are under constant attack, immune disorders are increasing at an alarming rate. Recent research has found that immune malfunction is an important contributing factor to conditions including heart disease, arthritis, and auto immune disorders. By fine-turning and supporting our immune system in order to prevent disease, we can make one of the best investments possible for our health and longevity.

The potential value of using hyperimmune egg for various health conditions has been shown by new research. Some of the most well-known doctors using alternative and complementary health treatments have found that hyperimmune egg supplements are extremely helpful in reversing a wide array of health problems. As research continues and understanding of how hyperimmune egg works increases, the application of hyperimmune egg can be expected to increase. Impressive properties found in hyperimmune eggs make them an excellent supplement for immune support. When we have a balanced and well-functioning immune system, our lives will be much healthier and happier.



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Is Saw Palmetto's Safe?
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Date: July 15, 2008 06:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Saw Palmetto's Safe?

Saw palmetto, a small palm tree which is found in Florida and South Carolina, produces berries which contain many beneficial compounds. Florida is the biggest producer of saw palmetto. Small patches of this herb can be found from the southeast coastline of South Carolina and southeastern Georgia to southern Mississippi. But it does not grow naturally in Texas, Mexico, or the Caribbean. It grows in every Florida County, but much of its production is found in South Florida.

Supplements that contain saw palmetto are extremely effective in treatment of Benign Prostate Hyperplasia (BPH), one of the most common health conditions in older men, with half of all men aged 40-60 and more than 90 percent of men over 80 having BPH. BPH is caused by the conversion of estrogen to a very potent form of testosterone called dihydrotestosterone (DHT). Saw palmetto berry extract has been found to relive the symptoms of BPH by furthering the production of DHT. With the use of saw palmetto extract, it has been found that most men achieve some relief of symptoms within the first 30 days.

Additionally, saw palmetto is an herb that is commonly used to treat benign prostate enlargement, is rich in phytosterols, especially beta-sitosterol. Also, saw palmetto is very effective for excess testosterone, as it promotes testosterone excretion. Native Americans use the fruit for food, but it is also used in the treatment of a variety of urinary and reproductive system problems. Similarly, the Mayans drank it as a tonic, while the Seminoles used the berries both as an expectorant and as an antiseptic.

Recent concerns over the safety of saw palmetto supplements for prostate health have emerged and may be unfounded. A new study reported that there were no adverse effects from the supplementation of saw palmetto. The randomized clinical trial, Saw palmetto for Treatment of Enlarged Prostates (STEP) study, recruited two hundred and twenty-five men, all of which had moderate-to-severe symptoms of benign prostatic hyperplasia (BPH). Each of these men was assigned to receive either 320 milligrams per day of a saw palmetto supplement or a placebo.

This study lasted one year. After the study, researchers concluded that there were no significant Differences between the groups when it came to suffering from at least one serious adverse event. 5.4 percent of men in the saw palmetto group had one serious adverse event as compared to 9.7 percent in the placebo group. There were also no significant Differences that were observed when it came to non-serious symptomatic adverse events, as 34.8 percent of men in the saw palmetto group experienced such an event, compared to 30.1 percent in the placebo group.

The study was welcomed by Daniel Fabricant, PhD., vice president of scientific and regulatory affairs for the industry association of the Natural Products Association. Dr. Fabricant said that he agreed with the authors of the study and that the results are reassuring, saying that he believe the study supports the viewpoint that those people with experience in botanicals have held for an extended amount of time in that when they are used responsibly and the amounts and concentrations are supported by clinical literature, botanicals are extremely safe and effective.

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Weight Loss and Calories
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Date: June 24, 2008 02:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Weight Loss and Calories

Although conventional wisdom argues that a calorie is a calorie, regardless of where it comes from, whether that be from a salmon fillet or an ice cream cone. But you don’t have to be a nutritionist to realize that there’s a huge difference between the nutrition of salmon verses that of ice cream. Legions of chronic dieters understand the Differences, based on their personal experiences. For example, they claim that they gain a large amount of weight after eating one slice of pizza that is rich in carbohydrates, but do not after eating a large chicken breast and steamed broccoli meal that contains even more calories.

There is now a legitimate scientific explanation for why some calories are different from others. Doctors Eugene J. Fine, MD, and Richard D. Feinman, PhD, of the State University of New York Downstate Medical Center in Brooklyn have explained that the widely held calorie-is-a-calorie belief is based on the law of thermodynamics, which is a key concept in physics. The first law in thermodynamics is about the amount of energy that goes into a system being equal to the amount of energy being released. To lose weight along this line of thinking, you need to either eat fewer calories or burn off more of them.

However, researchers have pointed out that the second law of thermodynamics can be associated with living creatures. The second law of thermodynamics claims that an inherent variation and inefficiency in all biological and biochemical processes. This can also be understood by saying that people burn energy less efficiently than cars and light bulbs do, while some people burn energy less efficiently than other people do.

There are many reasons that a calorie is not always a calorie. If you have a higher resting metabolic rate, you will do a much better job of burning all sorts of calories, as compared to someone who has a lower metabolic rate. If you secrete a lot of insulin due to being pre-diabetic or overweight, then you’ll be much more likely to make fat than muscle. Also, if you eat foods that have transitive fats, you’re a lot more likely to gain weight around your waist. It is recommended that people eat the highest quality of calories as possible. This includes nutrient-dense foods such as fish, chicken, fresh vegetables, minerals, quality protein, and healthful fats. These foods provide us with the most vitamins that are necessary for a healthy and balanced diet.

The alternative, which is not recommended, is a lot of sweets, soft drinks, breads, pastas, bagels, and muffins. These foods provide mostly empty calories in the form of sugars and starches. These foods also trigger the production of excess insulin, which will cause you to store these calories mostly around your waste, which is an occurrence that is definitely unwanted by the majority of people.

Due to the above facts, we can finally conclude that a single calorie from a salmon fillet is not the equivalent to a single calorie from an ice cream cone, as the calorie from the salmon fillet is packed with many more vitamins and nutrients that the ice cream cone is lacking.

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Oregano oil hi in Carvacrol
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Date: April 25, 2008 02:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Oregano oil hi in Carvacrol

VitaNet ®, LLC is pleased to distribute Nature’s Answer Oil of Oregano—one of the finest quality oregano oils available today. Nature’s Answer offers you a concentrated oil of true oregano, Origanum Vulgare, steam-distilled in a base of extra virgin olive oil. There is a lot of confusion about oregano, because many plants throughout the world are called oregano. For example, marjoram (origanum marjorana) is a close cousin to true oregano, and Spanish and Mexican oregano are actually different plant species. It is important to be aware of these Differences, because only Origanum Vulgare contains high amounts of the active ingredient, carvacrol. This is the exact species that Nature’s Answer uses in its products.

It takes approximately 200 pounds of oregano to produce two pounds of Nature’s Answer Oregano Oil. This highly concentrated form yields a quality plant product, retaining all the important volatile oils intact, true to Nature’s Answer’s philosophy of maintaining the plant’s Holistic Balance.

Holistic Balance guarantees that the natural constituents of our herb products are in the same synergistic ratio as those found in the plant; an herb of this type reflects the natural balance of the plant, and all of its many micronutrients.

Oregano is rich in nutrients including vitamin A and C, niacin, calcium, magnesium, zinc, iron, potassium, copper, boron, and manganese. It also contains the active chemical constituents, thymol and carvacrol. These components have shown strong activity in protecting cells against foreign organisms.

The protective properties of oregano have been recognized by traditional herbalists throughout history as well as supported by modern scientific research. Oregano is also a powerful antioxidant, offsetting the adverse effects of free radicals on out bodies. Oregano oil has been shown in scientific studies to support intestinal, digestive and respiratory health and can also be used topically for minor skin irritations.

Each four-drop dose of Nature’s Answer Oil of Oregano provides 13mg of oregano oil, which is guaranteed to contain a minimum of 7mg of carvacrol. Nature’s Answer Oil of Oregano liquid and its high quality oregano oil in softgel form are always on deal at VitaNet ®, LLC Health Food Store.

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Depression and Vitamins
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Date: April 17, 2008 11:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Depression and Vitamins

Most men dealing with depression have stories that are very similar, waking with a heavy head even in the happiest of times. A bad day is described as one in which you can’t get out of bed and it feels as if there is a dark cloud hanging over your head. Today, as the NFL season moves towards playoffs, many athletes are living with depression related to multiple concussions. A study of over 2,500 retired NFL players concluded that three concussions triple the chance of experiencing depression. This is extremely important in a sport in which brain trauma is so often and easily dismissed.

Just like helmets cover the faces of men playing a violent game, the angry aggression that is so commonly associated with normal guy behavior may actually be a mask for depression and physical injury is not needed to suffer its effects. It has actually been discovered that depression is more common in men than anyone ever knew, as male depression has often been under-diagnosed because the standard diagnostic manual portrays the depression symptoms more commonly associated with women. About six million men will be diagnosed with depression in 2008, not counting the one million more that will go undiagnosed.

The sad weepiness that is commonly associated with depression is much more commonly found in women, while a man is more likely to be short-tempered, fatigued, and uninterested in sex, work, or hobbies. However, it is work that provides depressed men a distraction to their painful inner feelings. Men are more likely to try downing their pain in alcohol or drugs instead of getting treatment. Untreated depression explains why the male suicide rate is more than four times the rate of female suicide. Although there are hormonal Differences in depression of the different genders, the common factor is stress.

Although some men are open to being told they are depressed, most only act out with more anger. An effective, but not exactly subtle approach to telling a man he may have depression is leaving and article or book around the house for him to pick up. Severe depression requires immediate attention by a trained practitioner, along with various medical interventions. Once the worst is over, it is important to try to maintain a depression-free lifestyle. This can be done by reduction stress and finding social support as well as dietary changes.

This is a difficult step for men who are used to conversations which revolve around scores and transactions, but good places to start are men’s groups at houses of worship (church) or those groups such as AA if substance abuse is part of the problem. By fortifying the brain with depression-fighting nutrients, including a B vitamin complex, one can maintain and promote normal mental functioning. Many depressed people are extremely deficient in folic acid as well as dietary essential fatty acids.

Omega-3 fatty acids are needed to build healthy brain cells, along with phosphatidyl serine. Other herbs, including eleuthero, rhodiola, and ginseng, can help the body to adapt to stress, while St. John’s wort and SAMe work as natural antidepressants.

The most severe mistake that can be made is to play down depression, which applies to raging men just as much as it does to weeping women. Both genders need to seek help if feeling this way. If you feel you are experiencing depression, seek professional help as well as look into dietary changes, exercise, and the support of family can be a good start to a healthier outlook on life.

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Ubiquinol
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Date: October 24, 2007 11:37 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Ubiquinol

Benefits

Ubiquinol has powerful antioxidant actions in target cells *

 

Although ubiquinone (oxidized coenzyme Q10) and ubiquinol (reduced coenzyme Q10) are kept at a constant ratio within the body, the majority of the total coenzyme Q10 pool is made up of ubiquinol.  In fact, when ubiquinone is taken orally, much of it appears to be rapidly converted into ubiquinol. 1,4 Ubiquinol functions as a potent antioxidant in humans, including in low-density lipoproteins (LDLs) where it protects them from oxidative damage.1,4,5 The coenzyme Q10 molecule can be found in all membranes throughout cells.6 It appears to works in conjunction with both vitamin E and vitamin C to provide antioxidant actions throughout the body.7

 

Coenzyme Q10 supports mitochondria to enhance cellular energy production*

 

Coenzyme Q10, with its widespread distribution throughout the body, plays a crucial role in mitochondrial physiology as a critical member of the electron transport chain. This transport chain, which is part of cellular respiration, leads to the formation of adenosine triphosphate (ATP), our body’s primary energy source.  Levels of this key nutrient may decline as a healthy person ages.7,8  Animal studies have found that supplementation can restore normal levels in certain tissues 6, and human studies suggest that supplementing with this enzyme may have increased benefits when a person has depleted levels. 7

 

Coenzyme Q10 supports healthy heart functioning*

 

Concentrations of coenzyme Q10 are understandably high in the heart as these muscle cells require high levels of energy to constantly function optimally. A number of studies (both animal and human) strongly suggest that coenzyme Q10 supplementation is supportive for healthy heart functioning and for maintaining cardiovascular system health.7,9

 

Ubiquinol has been studied for safety and bioavailability in humans*

 

A recently published single-blind placebo-controlled study in healthy subjects found no safety concerns in people who took Kaneka’s QH ubiquinol supplement orally at doses of up to 300 milligrams daily for up to four weeks.4 Single oral doses of either 150 milligrams or 300 milligrams were given to fifteen healthy men and women, and standard laboratory testing (including hematology, blood chemistry, and urinalysis) as well as physical examination and electrocariography (EKG) results showed no clinically significant changes when tested two days after supplementation as compared to before the taking the supplement. In addition to the single dose study, 80 healthy volunteers were given either placebo, 90, 150 or 300 milligrams of ubiquinol each day for four weeks, and again no clinically significant Differences were seen in any of the testing parameters after two and four weeks of supplementation, nor were there Differences two weeks after discontinuation of the supplement.  By monitoring levels in the blood, the authors found that ubiquinol was well absorbed.4

 

Studies in several animals also reveal no concern of toxicity in doses of ubiquinol up to 200 milligrams per kilogram of body weight for up to thirteen weeks.4 When compared to humans, this dose level is enormously higher than the recommended doses.  Supplementation with ubiquinol appeared to be safe at even higher levels (up to 600 milligrams per kilogram body weight) in a study using a different animal. In vitro assays additionally found no safety concerns for the use of ubiquinol, as it was found to be non-mutagenic and did not cause damage to chromosomes in cells.

 

Safety

Suggested Adult Use: Take one softgel daily with food, or as directed by a nutritionally informed physician.

 

Scientific References

1.    Mohr, D., V.W. Bowry, and R. Stocker, Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta, 1992. 1126(3): p. 247-54.

 

2.    Weber, C., et al., Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med, 1994. 15 Suppl: p. s97-102.

 

3.    Okamoto, T., et al., Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res, 1989. 59(3): p. 288-92.

 

4.    Hosoe, K., et al., Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol, 2007. 47(1): p. 19-28.

 

5.    Stocker, R., V.W. Bowry, and B. Frei, Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A, 1991. 88(5): p. 1646-50.

 

6.    Crane, F.L., Biochemical functions of Coenzyme Q10. Journal of the American College of Nutrition, 2001. 20(6): p. 591-598.

 

7.    Jones, K., et al., Coenzyme Q-10 and cardiovascular health. Alternative therapies, 2004. 10(1): p. 22-31.

 

8.    Schulz, C., et al., Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Int J Food Sci Nutr, 2006. 57(7-8): p. 546-55.

 

9.    Coenzyme Q10. Monograph. Altern Med Rev, 2007. 12(2): p. 159-68.

 



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Active Coenzyme Q10
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Date: July 07, 2007 01:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Active Coenzyme Q10

Active CoQ10

 

The benefits of Coenzyme Q10 have become increasingly well-known. This important nutrient has been shown in clinical trials to improve heart function, reduce the side effects of certain drugs used to treat cancer, and slow the progression of serious brain diseases such as Parkinson’s disease. Now research has opened a new chapter in the CoQ10 story, highlighting the benefits of ubiquinol, the active form of CoQ10, to increase energy and stamina, and reduce some of he physical signs of aging.

In this issue of Ask the Doctor we will review the benefits of Coenzyme Q10, and discuss the Differences between CoQ10 and its active form –ubiquinol.

 

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone. That’s because CoQ10 is ubiquitious and exists everywhere there is life. CoQ10 is vital to adenosine triphosphate (ATP) production. ATP is the energy-rich compound used for all processes requiring energy in the body. Although CoQ10 is produced by the body and exists in some limited dietary sources, these levels may be insufficient to meet the body’s requirements. CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. Also, some drugs, especially a group of cholesterol lowering prescription drugs known as “statins,” (Pravachol, Zocor, Lipitor, etc.) significantly reduce CoQ10 levels in the body.

 

Q. What is ubiquinol? Is it the same or different from CoQ10?

A. Ubiquinol and CoQ10 are very closely related. Ubiquinone, or CoQ10, is the oxidized form of the molecule. This means it has to be converted to a non-oxidized form before it can perform its work. Ubiquinol is the active form of this nutrient. Our bodies convert CoQ10 to ubiquinol – which is the form needed to produce cellular energy. Until recently, it was not possible to use ubiquinol as a supplement because it is very unstable outside the human body. But research has now found a way to keep this molecule stable so it can be successfully taken in supplement form.

 

Q. If CoQ10 gets converted to ubiquinol anyway, can’t I just take CoQ10?

A. While it is true that our bodies can convert CoQ10 to ubiquinol, it isn’t true that we all do this equally well. In fact, as we age, our ability to convert CoQ10 to ubiquinol declines. And some people even have a gene that makes them less effective at this conversion than the majority of the population. IN fact, several common health issues have been associated with less than optimal ratios of CoQ10 to QH. For healthy people the ideal ratio is approximately 97% Ubiquinol to 3% CoQ10. But in people with diabetes, for example, the ratios have been found to range from 43% ubiquinol to 47% CoQ10 in mild diabetes, to only 24% ubiquinol to 76% CoQ10 in severe diabetes. These numbers are for men; the numbers for women vary by 2 to 5 percentage points.

So for older folks, the 30-50% of people who have the gene that impairs CoQ10 conversion, or for people who have serious health concerns, supplementing with ubiquinol instead of CoQ10 might be the smart choice.

 

Q. What are the health benefits of CoQ10 and Ubiquinol?

A. There have been many studies showing that CoQ10 is beneficial in treating and preventing heart disease and conditions such as high blood pressure atherosclerosis (hardening of the arteries), angina, and congestive heart failure (CHF). It’s been shown that heart attacks tend to occur when CoQ10 levels are low in the body. Exciting new research has found that CoQ10 in a unique delivery system supplementation may slow the progression of symptoms associated with neurological diseases such as Parkinson’s disease, ALS, Huntington’s disease and Alzheimer’s disease.

In addition, CoQ10 is beneficial for diabetes, immune dysfunction, cancer, periodontal disease, prostate cancer, and neurological disease. While the research on ubiquinol is still very new, it is reasonable to expect that its benefits will be equal to or perhaps even better than CoQ10, because it is the more active form.

 

Q. Why is CoQ10 especially important for preventing and treating heart disease, and for neurological diseases like Parkinson’s disease?

A. The heart and brain are some of the most metabolically active tissues in the body. Both require large amounts of uninterrupted energy, which means these tissues also need increased amounts of ubiquinol. Research has shown that many people with heart of brain diseases have serum CoQ10 levels that are lower than those of healthy people. Correcting such deficiencies often can produce significant results. However, these diseases become more common as we age – right at the time our ability to convert CoQ10 to its active form, ubiquinol, declines.

 

Q. How might ubiquinol be important for the heart?

A. Heart Health: A study on patients admitted to the hospital with an acute myocardial infarction (AMI) found that CoQ10 can provide rapid protective effects in patients with a heart attack if administered within three days of the onset of symptoms. Seventy-three patients received CoQ10 (120 mg/d). The study’s control group consisted of 71 similarly matched patients with acute AMI. After treatment, angina pectoris (severe chest pain signifying interrupted blood flow to the heart), total arrhythmias (dangerously irregular heartbeats), and poor function in the left ventricle (the essential chamber of the heart) were significantly reduced in the CoQ10 group compared to the placebo group. Total deaths due to sudden cardiac failure and nonfatal heart attacks also were significantly reduced in the CoQ10 group compared with the placebo group.

In another study, CoQ10 was studied in 109 patients with high blood pressure (hypertension). The patients were given varying doses of supplemental CoQ10 with the goal of attaining a certain blood level (greater than 2.0 mcg/l). Most patients were on medications to treat hypertension. Half the patients were able to stop taking some or all of their prescription drugs at an average of 4.4 months after starting CoQ10. The 9.4% of patients who had echocardiograms, performed both before and during treatment, experienced a highly significant improvement in heart wall thickness and function. This improvement was directly attributed to CoQ10 supplementation.

Congestive heart failure (CHF) is a debilitating disease that affects 5 million people in the U.S. It causes edema, difficult breathing, and impaired circulation. In another study, CoQ10 restored healthy heart function in CHF patients. Patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the investigators introduced a catheter into the right ventricle of patients’ hearts to determine the degree of CHF damage to the heart muscle. The patients’ heart muscles at rest and work improved significantly. The researchers concluded CHF patients would greatly benefit from adjunctive CoQ10 treatment. Since ubiquinol is the active form of CoQ10, it may be able to overcome the hurdles to providing maximum impact, most importantly, age and genetic related inefficiencies in converting CoQ10 to active CoQ10 (Ubiquinol).

 

And Neurological Health?: A study sponsored by the National Institutes of Health showed that supplementing with CoQ10 in a unique delivery system was associated with a slowing of the progression of Parkinson’s disease. Participants were divided into 4 groups and their physical skills (coordination, walking, etc) and mental skills were evaluated. Each group then received 300 mg, 600 mg, or 1200 mg of a special form of chewable CoQ10, or a placebo. The researchers evaluated the participants after 1, 4,8, 12, and 16 months of treatment. Each participant was again scored on motor, mental, and activities of daily living skills.

The results of the study showed that the people who took the highest dosage of CoQ10-1200 mg-experienced the least decline in their physical abilities. The results were so encouraging that the researchers will be continuing with new studies, suing higher dosages to see if the results can get even better.

Huntington’s disease (HD) is a devastating and degenerative inherited disease that is always fatal. In fact, no other medication, drug, or nutritional supplement has ever been shown to cause a decline in the progression of this terrible disease. A study compared CoQ10 against remacemide (an investigational HD drug made by AstraZeneca Pharmaceuticals), in 347 HD patients who were in the early stages of the disease. Remacemide blocks glutamate, the neurotransmitter scientists think may cause the death of brain cells that occurs in Huntington’s disease. While remacemide had no effect on the progression of HD, CoQ10 showed a trend toward slowing the disease by an average of 15%. This meant the HD group taking CoQ10 was able to handle every day activities of life a little longer than the patients taking remacemide or a placebo. They also were able to focus their attention better, were less depressed, and less irritable.

The 15% slowing of decline can result in about one more year of independence of HD patients. Needless to say, the gift of an additional year of health in the lives of HD patients is incredibly significant.

Because of these impressive results, researchers are hopeful that supplemental CoQ10 will have beneficial effects for people with other neurological diseases such as ALS and Alzheimer’s disease, too. Studies are under way to confirm these effects.

Using the active form of CoQ10 helps to assure that, regardless of age or illness, the CoQ10 can have the greatest impact.

 

Q. What have been the results of research studies with Ubiquinol?

A. One of the most interesting effects of Ubiquinol that has been reported so far is its ability to slow the physical signs of aging. In laboratory studies, administration of stable ubiquinol to mice forestalled the changes associated with aging – rounded spine, patchy fur and irritated eyes. While the mice who received ubiquinol did not necessarily live longer than the mice that didn’t, they lived better. But it is important to note that these mice were bred to die at a young age. Human studies are needed to determined true impact on longevity.

Additionally, supplemental, stable ubiquinol has been shown to increase physical energy and stamina. In an animal study, the length of time rats were able to run on a treadmill before getting tired was measured. The same rats were then given ubiquinol and the treadmill test was repeated. The length of time the rats were able to run before tiring increased 150 times.

 

Q. How can one supplement have applications for neurological diseases, heart health, and even the immune system?

A. Supplements often have more than one function, especially when it’s a substance like CoQ10, which is present in all parts of the body. All nucleated cells (most cells other than red blood cells) have mitochondria and all cells require energy to function. CoQ10 is vital to ATP production. Thus, CoQ10 has applications not only in neurological (neurons or nervous system cells) and cardiac health (myocardium or heart tissue), but also for the immune system.

 

Q. Should I take CoQ10 or ubiquinol? How much should I take?

A. While everyone can benefit from CoQ10 or ubiquinol supplementation, it appears that ubiquinol should be the first choice for older adults, people with known genetic inefficiencies in converting CoQ10 to ubiquinol, and for people with serious heart disease or neurological diseases such as Parkinson’s disease, who are otherwise supplementing with high levels of CoQ10. For people in overall good health, a high quality CoQ10 supplement with proven absorption is a good choice.

Take 200 to 300 mg of CoQ10 or 100 mg ubiquinol daily, depending on your health history. The safety of both forms has been tested, and no significant side effects reported. Occasional mild stomach upset may occur. Taking your CoQ10 or ubiquinol with meals usually alleviates this rare effect.

 

Conclusion
CoQ10 is not the only answer to the complex issues of heart disease, neurological diseases, or immune dysfunction; however, research indicates that it’s a bigger piece of the puzzle than physicians and scientists ever imagines. The more we study this naturally occurring compound, the more benefits we find. And with this new ability to provide CoQ10 in its active form, ubiquinol, for the first time, even greater benefits may be derived.

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Turmeric and Alzheimer’s Disease
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Date: May 10, 2007 12:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Turmeric and Alzheimer’s Disease

Turmeric and Alzheimer’s Disease

 

In India, Alzheimer’s disease is relatively uncommon. People over the age of 65 living in certain rural areas of India have a less than 1 percent (0.84) chance of developing the disease. In the larger cities and rural areas of India, the risk is just 2.4 percent.

Compare these findings to people over the age of 65 living in the United States. Again, depending on where we are living, our chances of developing Alzheimer’s disease range from a little under 5 percent to an astonishing 17 percent.

So what are people who are living in India doing that we aren’t doing here in the US to account for these dramatic Differences? The answer seems to be curry, that zesty spice and staple of Indian foods. Research has shown that a compound in curry not only prevents changes in the brain that lead to Alzheimer’s disease; it actually reverses some of the damage already present.

 

Q. How can curry prevent these changes in the brain? Isn’t that a lot to expect from a spice?

A. Evidently, it’s not too much to expect from this spice. Curry comes from the turmeric plant – Curcuma longa is the plant’s official name. Curcumin, a plant compound in turmeric, is the source of curry’s instantly recognizable bright yellow pigment. When it comes to the scientific research of Curcuma longa, the terms curcumin and turmeric are both used. Both refer to the same thing- tumeric extract.

There have been more than 1300 studies on tumeric and its health benefits for humans. Research has shown tumeric is able to help the body get rid of cancer-causing toxins. Turmeric also blocks estrogen receptors and enzymes that promote cancer. And it’s been found to stop the growth of new blood vessels in cancerous tumors – an important factor in keeping cancer from getting larger and spreading throughout the body.

But one of turmeric’s most exciting health benefits is its ability to reduce, prevent, and stop inflammation. While inflammation is a normal and needed response to injury or disease, chronic inflammation can cause damage to tissues. And researchers are now finding inflammation plays a huge role in Alzheimer’s disease.

 

Q. I’ve always heard that Alzheimer’s disease was caused by complex growths in the brain called plaques and tangles. How can simple inflammation cause such a devastating disease?

A. You are right. Plaques and tangles are indeed the hallmarks of Alzheimer’s disease. But researchers looking at the brain damage caused by Alzheimer’s have always noted the presence of inflammation wherever plaques and tangles form. In the past, this inflammation was thought to be simply a consequence of Alzheimer’s disease. Now scientists believe the inflammation itself starts a chain reaction ultimately contributing to the development of Alzheimer’s disease.

` When cells in the brain are disrupted by inflammation, amyloid, and a protein normally found in the brain, beings to act chaotically. This chaos results in the creation of beta-amyloid, protein that is toxic to cells in the brain. Sticky deposits of beta0amyloid build up and collect around the cells, making dense clumps or plaques. Because the brain can’t break the plaques down and get rid of them, they stay right where they are and slowly accumulate.

Tangles result when long protein fibers that act like scaffolding for brain cells begin to twist and tangle. The cell is damaged and eventually dies. But the tangled proteins remain in the brain even after the dead neuron has been cleared away. And inflammation might be the culprit causing the long protein fibers to start tangling.

The consequence of these abnormalities of protein in the brain is more than the cell death they cause. They also act as roadblocks interfering with electrochemical messengers being shot from cell to cell. Therefore, the remaining healthy cells’ activity is diminished as well.

Research of identical twins has repeatedly shown that if one twin has Alzheimer’s disease, the other has a 60% chance of developing the disease, too. Scientists from the Karolinska Institute in Stockholm, Sweden, looked at information from 20,000 twins collected in the 1960s and found 109 pairs of siblings where only one twin had been diagnosed with Alzheimer’s. When the Swedish researchers analyzed data about the twin’s health, they found the twin with Alzheimer’s disease almost always had chronic gum disease. While bleeding gums are definitely not he cause of Alzheimer’s disease, the inflammation that plays a large part of chronic gum disease may signal an inflammatory process stuck in overdrive.

In fact, the inflammatory process might occur years before the onset of Alzheimer’s, and be the result of any number of infections people can contract. That’s why current research is searching for ways to protect brain cells from inflammation. And why some countries have low rates of Alzheimer’s disease, like India.

 

Q. Why curry? Couldn’t other lifestyle difference account for the low rates of Alzheimer’s disease in India?

A. That’s a good question. When researchers begin studying a disease, like Alzheimer’s, they look for trends to help them determine how and why the disease occurs. For example, we all now know the connection between cigarettes smoking and long cancer. But, it wasn’t until the 1930’s that doctors noticed the trend fro cigarette smokers to have more lung cancer than people who didn’t smoke.

So it has been with researchers studying Alzheimer’s disease. They know Alzheimer’s disease has an important connection to inflammation. They also know turmeric reduces inflammation. And when researchers noticed these trends – that people in India eat high amounts of curry from turmeric and have very little Alzheimer’s disease – they began to theorize that turmeric might be able to prevent or even treat the illness. And the research they designed around these trends has unequivocally found turmeric to be on common denominator.

 

Q. What have the turmeric studies shown so far?

A. Simply amazing findings are coming from curry research. Not only does turmeric slow down cancer growth, it’s also been found to correct the cystic fibrosis defect in mice, help prevent the onset of alcoholic liver disease, and may slow down other serious brain diseases like multiple sclerosis.

Researchers from the University of California Los Angeles (UCLA) studying turmeric have found it to be more effective than the drugs currently being investigated for Alzheimer’s disease treatment and prevention. The researchers have discovered the actual structure and shape of turmeric allows it to penetrate the blood-brain barrier effectively and bind to beta amyloid that’s already built up in the neurons. Turmeric helps maintain healthy brain cellular metabolism, helps the cells repair themselves, and keeps the cells connected to each other. In other words, turmeric helps brain cells stay healthy.

And now the UCLA Alzheimer’s Disease Research Center (ADRC) is using turmeric in clinical trials and studying the effect of this powerful spice in patients diagnosed with this devastating disease. Clinical trials are the gold standard of medical research. But it’s rare in Alzheimer’s disease. And it’s even more rare when all-natural herbs and spices like turmeric are used in hopes the positive benefits will be discovered. The head of the UCLA’s research team was recently interviewed and stated that setting out to hopefully prove turmeric’s ability to prevent and treat Alzheimer’s disease was “tremendously exciting.”

 

Q. I recently read that one of the non-steroidal anti-inflammatory drugs (NSAID) was found to prevent Alzheimer’s disease. Is this true?

A. Scientists recently studied ibuprofen, one of the NSAIDs investigated for Alzheimer’s disease Prevention. Ibuprofen belongs to a family of drugs that includes naproxen, indomethacin, nabumetone, and several others. These drugs are used most often to get rid of headaches, mild arthritis, and other kinds of pain and inflammation.

In the studies, the average dose of ibuprofen was 800mg a day. Patients took the product for two years. While the results suggested that ibuprofen might reduce the risk of developing Alzheimer’s, ibuprofen’s side effects are too harmful to be a valid lifelong prevent aid treatment. Ibuprofen, like other NSAIDs, can cause gastrointestinal bleeding when used at high dosages over a long period of time. Long term use of ibuprofen can also lead to analgesic nephropathy, a kind of kidney damage caused by NSAIDs.

As we discussed earlier, turmeric appears to block and break up brain plaques that cause the disease and helps reverse some of the damage already present. Ibuprofen does not provide any protection against free radical damage. No anti-inflammatory medicine can do this.

 

Q. If I eat curry will I be protected against Alzheimer’s disease? There aren’t many foods or recipes I make that require curry, do I need to eat it every day? And how much do I need?

A. If you enjoy Indian cuisine, by all means, enjoy these delicious foods. You’ll benefit your brain and your appetite. But you make a good point, American meals rarely contain curry. That’s why supplements that contain extracts are suddenly quite popular. In fact, there are numerous turmeric/curcumin supplements on the market today.

But like all nutritional supplements, some turmeric supplements are superior to others. You need to read their labels to make sure the turmeric extract you are buying will provide the protection you need. Look for high-potency turmeric extract from turmeric (Curcuma longa) rhizome. And make sure the extract is standardized to contain 90% curcuminoids, the active ingredient in turmeric responsible for the positive research findings.

 

Conclusion

Researchers once thought that preventing for Alzheimer’s disease would elude them for decades. In fact, several scientists privately speculated the disease might never be ameliorated. They thought the origin of the disease was too complex and the symptoms of the disease were too profound.

That’s why ongoing research on turmeric is so exciting. A safe, natural, and effective way to protect against Alzheimer’s disease almost seems too good to be true. But, the nation of India and its low incidence of Alzheimer’s disease are proof these are not just fluke findings – making turmeric extract a supplement to remember.

 



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D-Ribose Powder Benefits!
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Date: April 10, 2007 11:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: D-Ribose Powder Benefits!

Benefits

Supports normal heart function*

A significant amount of in vitro, animal and human research suggests benefits of ribose on heart function.* Studies have shown that ribose supplementation can enhance cardiac energy levels and support cardiovascular metabolism.* Ribose has been shown in clinical trials to enhance the recovery of heart muscle ATP levels and improve myocardial function following exercise.

Studies suggest that ribose supplementation can increase the tolerability of the cardiovascular system to exercise-induced fatigue.1 In one study, twenty men underwent treadmill exercise tests on two consecutive days to confirm the onset of fatigue secondary to exercise. The participants were then randomized to the treatment group or a placebo group. The groups received either four doses of 15 grams of D-ribose (60 grams/day total) or the same amount of placebo each day. After three days of treatment, another treadmill test was performed. The time it took to reach the specified level of fatigue was significantly greater in the ribose group than in the placebo group.

Another study investigated the ability of ribose to support healthy heart function and quality of life.2 In a randomized, crossover design study, fifteen individuals were given 5 grams three times a day of either D-ribose or placebo. Each treatment period lasted three weeks. In patients receiving ribose, echocardiography demonstrated enhancement of heart function, reflecting a “more efficient relaxation phase of the heart”. Participants also had a significant improvement in their subjective quality of life scores compared to placebo.  

Scientists suggest that suboptimal heart function is a result of the heart requiring more energy to function properly. Ribose supports the heart’s enhanced energy requirements, promoting optimal heart function. It does so by enhancing the stores of high-energy phosphates in heart tissue. These intermediates are necessary for the production and resynthesis of ATP. A double-blind crossover study in which 12 individuals were randomized to receive either ribose or dextrose (both administered as 5 grams three times daily for three weeks, followed by a 1-week washout period and crossover of treatments for three additional weeks) suggested significant enhancements in normal cardiac function during the period of ribose supplementation.3

Perhaps one of the more useful illustrations of the potential for ribose to support heart function comes from a study in which 20 rats received a continuous infusion of ribose for 24 hours (control rats received an infusion of saline). The hearts were then explanted (as they would be for heart transplants) and placed in preservation solution that was enriched with ribose for 4 hours. ATP levels were measured from tissue biopsies and revealed that 10 of the ribose-treated hearts had ATP levels higher than 12.3 micromoles per gram whereas saline-treated hearts (controls) had lower ATP levels, with 20% showing levels below 10 micromoles per gram of tissue. This provides support for the hypothesis that ribose may enhance the preservation of ATP levels in cardiac tissue, promoting normal heart function.4

Further animal studies have shown that ribose significantly enhances heart function after experimentally induced cardiac depression. Rats were injected with isoproterenol (a drug that stimulates sympathetic nervous system function) and had their abdominal aorta constricted to induce depression of heart function and reduce cardiac ATP levels. The decrease in ATP was primarily responsible for the depression of heart function. Continuous infusion of ribose for 24 hours replenished ATP concentrations to normal levels and normalized heart function in these animals.5

Ribose may strengthen and support the body’s crucial antioxidant defenses*

Ribose may support the body’s innate antioxidant mechanisms while promoting an antioxidant effect of its own. Intense exercise and other strenuous activity can induce the production of free radicals. Preliminary studies suggest that ribose can attenuate some of the effects of oxidation seen after performance of intensive exercise.

One small human study indicated that ribose administered at a dose of seven grams before and after a bout of cycling exercise may reduce free radical production.6 Seven volunteers ingested either ribose or placebo both before and after intense exercise. Markers of lipid peroxidation, including malondialdehyde, significantly decreased in the ribose-supplemented group, while increasing in the control group. The results of this study indicate a possible effect of ribose in supporting antioxidant activity.

Supports healthy energy levels in heart and muscle tissue*

After bouts of intense exercise, ATP levels have been shown to decrease by an average of 15 to 20%.7 The amount of ATP stored in the muscle is limited and so the body must have the potential to rebuild ATP stores. ATP is the fuel necessary for the integrity and function of a cell. In addition, several studies have found correlations between ATP content and heart function.1 Research that was also alluded to above suggests that ribose stimulates ATP synthesis and supports heart and muscle function by enhancing ATP levels in cardiac and muscle tissue. D-ribose is an essential building block for the synthesis of ATP through the pentose phosphate pathway. 

The results of ribose supplementation enhancing ATP levels in muscle are evidenced by studies suggesting beneficial effects on anaerobic performance. In a randomized, placebo-controlled crossover study assessing the effects of acute ribose supplementation, participants receiving the ribose supplement had increases in mean power (a measure of average overall muscular strength output during the sprint) and peak power (a measure of the highest muscular strength output during the sprint) when undergoing a series of cycle sprints.8 While this effect was not noted in all of the six short cycling sprints that the participants underwent, the study does illustrate the potential benefits of ribose on ATP production and, secondarily, on enhancing exercise performance.

A second placebo-controlled trial investigated the effects of four weeks of ribose-supplementation (10 grams /day) on male bodybuilders. Of the 20 participants who were recruited, twelve completed the study. Each subject participated in a heavy-resistance training program designed to increase skeletal muscle mass. The effects of ribose on body composition (body weight, body fat, lean body mass, fat mass, and bone mineral content) were also assessed. The results suggested that ribose increased total work capacity and bench press strength compared to placebo, without altering body composition.9

Supports energy recovery after exercise*

Animal studies have suggested that the administration of ribose after exercise increases the rate of adenine salvage by five to seven-fold in muscle tissue7, supporting energy recovery after exercise. When ATP is utilized by muscle tissue, the degradation products include adenine nucleotides (Adenine is one of two purine bases that is a component of DNA). Adenine is recycled to synthesize DNA, and the salvage of adenine within the muscle tissue is crucial to energy recovery. Studies have shown that the presence of adequate ribose concentrations is the rate-limiting step in the purine salvage pathway. Therefore, increased adenine salvage could potentially help in the recovery and regeneration of ATP after intense bouts of activity.

A study investigated the effect of oral intake of ribose on the synthesis of AMP, a precursor to ATP.10 Participants performed intense cycle training for seven days. They then received either ribose (at a concentration of 200 mg/kg body weight, which is equivalent to 14 grams per day for an average 70 kilogram male) or placebo three times a day for the following three days. Exercise tests were performed again on day 4. Muscle biopsy samples were taken before the first training session, immediately after, and again five hours, 24 hours, and 72 hours after the last training session. No Differences were seen in exercise performance between the groups. The intense exercise caused the ATP levels in muscle to decrease in both groups. However, at 72 hours post-exercise, the ribose group exhibited a much higher ATP level than the placebo group. The muscle levels of critical building blocks for ATP, including total adenine nucleotides (TAN) and inosine 5’-monophosphate (IMP), were also significantly higher in the ribose group compared to the placebo group at 24 hours after exercise. Ribose-supplementation was shown to enhance the resynthesis of ATP after intense exercise.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Safety

Caution: Insulin-dependent diabetics and pregnant women should consult their physician before use.

Suggested Adult Use: Take 1 or 2 scoops mixed in water, juice or other beverage two times per day. May be taken with or without food.

Scientific References

1) Pliml, W., von Arnim, T., Stablein, A., Hofmann, H., Zimmer, H., Erdmann, E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. The Lancet. 1992;340:507-510.

2) Omran, H., Illien, S., MacCarter, D., St. Cyr, J.A., Luderitz, B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. The European Journal of Heart Failure. 2003;5:615-619.

3) Illien, S., Omran, H., MacCarter, D., St. Cyr, J.A. Ribose improves myocardial function in congestive heart failure. FASEB Journal 2001;15(5): A1142

 

4) Muller C., Zimmer H., Gross M., Gresser U., Brotsack I., Wehling M., Pliml W. Effect of ribose on cardiac adenine nucleotides in a donor model for heart transplantation. Eur J Med Res. 1998 Dec 16;3(12):554-8.

5) Zimmer H.G. Normalization of depressed heart function in rats by ribose. Science. 1983 Apr 1;220(4592):81-2.

6) Seifert, J.G., Subudhi, A., Fu, M., Riska, J.J. The effects of ribose ingestion on indices of free radical production during hypoxic exercise. Free Rad Biol Med 2002; 33(Suppl 1) S269.

7) Zarzeczny, R., Brault, J.J., Abraham, K.A., Hancock, C.R., Terjung, R. Influence of ribose on adenine salvage after intense muscle contractions. J Applied Physiology. 2001;91:1775-1781. 

8) Berardi J.M., Ziegenfuss T.N. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res. 2003 Feb;17(1):47-52.

9) Van Gammeren, D.V., Falk, D., Antonio, J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial. Current Ther Research. 2002;63(8):486-495.

10) Hellsten, Y., Skadhauge, L., Bangsbo, J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. 2004;286:R182-R188.



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Peppermint Oil for IBS
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Date: March 24, 2007 11:01 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Peppermint Oil for IBS

Irritable bowel syndrome (IBS) is a painful and frequently frustrating disorder of the intestines that’s often difficult to treat. Fortunately, there are scientifically studied natural products that effectively reduce the distressing symptoms of IBS.

Q. What is IBS?

A. IBS causes crampy pain, gassiness, bloating, and alterations in bowel habits. IBS is termed a functional disorder, because when the colon is examined, there is no visible sign of disease. While IBS causes significant pain and distress, no actual damage is occurring in the intestines.

There is a wide variability in IBS. Symptoms may be mild and fairly well tolerated. Or, the pain, discomfort, and bowel dysfunction may be disabling, limiting social interactions, employment, or travel.

While some individuals with IBS have diarrhea (frequent, loose stools with an urgent need to move the bowels), others have constipation (hard, infrequent stools that are difficult to pass). And, still others may experience both. Individuals with IBS also may have painful abdominal cramps and feel an urgent need to move the bowels, but are unable to do so.

Q. What causes IBS?

A. The small intestine receives digestive material from the stomach and delivers it to the large intestine (colon). About two quarts (2,000 ml) of digestive material enter the colon from the small intestine every day. The colon absorbs water and salts from the material, which is progressively moved through the colon. This progressive movement continues until most of the fluid and salts are absorbed into the body and stool is formed. The stool passes to the left side of the colon, where it is stored until a bowel movement occurs.

Because researchers haven’t been able to find actual damage in the colon, it once was suggested that individuals with IBS have emotional problems or are overly susceptible to stress. While stress may cause symptoms of IBS to intensify, it doesn’t cause the condition.

Recent study has determined the colon muscle of an individual with IBS spasms after only mild stimulation. It’s thought the symptoms of IBS are produced by hyperactivity of the intestines. In other words, the intestines of individuals with IBS are more reactive to stressors and diet than usual. Almost everyone has experienced abdominal queasiness in response to everyday stress or certain foods. This may result in a brief bout of diarrhea or an upset stomach. However, this response is exaggerated in individuals with IBS.

Q. How prevalent is IBS?

A. IBS is very common. In fact, it’s one of the most frequent problems seen by family physicians. It’s the most common disorder diagnosed by gastroenterologists (physicians specializing in the treatment of digestive disorders). The overall prevalence rates range from 10% to 20% of the general population in most industrialized countries. As a result, the pain and disabling symptoms associated with IBS result in significant socioeconomic costs, as wall as reduction in quality of life for many individuals.

Q. What are the symptoms of IBS?

A. Normal bowel function varies from person to person. Some people move their bowels daily, while others may only have two to three stools a week. A normal bowel movement is soft, formed, and is easily passed without cramping or pain.

IBS, however, causes abdominal cramps and pain, which are often severe and disabling. Bowel movements may be irregular and alternate between diarrhea and constipation. The diarrhea may be quite loose and watery. Mucous may be passed. There is often much straining, urgency, and feeling of incomplete evacuation (emptying). Abdominal bloating and passing of gas is common. Nausea, lack of appetite, heartburn, and belching may also be present. Sleep may be disrupted resulting in fatigue and lack of energy. Understandably, persons with IBS often feel anxious and depressed.

Diagnosis of IBS is usually based on the continuous presence or recurrence of these symptoms for at least three months. Other intestinal conditions must be ruled out. These include Chron’s disease, ulcerative colitis, inflammatory bowel disease, colon cancer, inflammatory conditions of the stomach or pancreas, ulcers, infectious disease, or gastroesphageal reflux disease.

Q. Are there clinically demonstrated natural alternatives to the over-the-counter drugs prescribed by my doctor?

A. Yes, both enteric-coated peppermint oil and clown’s mustard (in combination with other herbs) have significant scientific research behind them. Both have been demonstrated to benefit individuals with IBS.

Q. What is clown’s mustard and what does it do?

A. The scientific name for clown’s mustard is Iberis amara. Other names for this herb are wild candytuft and bitter candytuft. Clown’s mustard is a white-flowering plant from Spain, where it grows in dry soil on hillsides and in cornfields. It is also grown in Britain, France, and the United States. Iberis amara is a member of the Brassicaceae family. Iberis refers to its place of origin, the Iberian Peninsula. Amara means bitter. The key components of clown’s mustard are glycosides and flavonoids that have specific actions on gastrointestinal tract tone.

Q. Is there scientific evidence that clown’s mustard benefits people with IBS?

A. There has been very impressive research on clown’s mustard (in combination with other herbs). And, it has been used with great success in Germany for many years to treat IBS and other gastrointestinal diseases.

In a study of an herbal combination containing clown’s mustard, 20 patients were given the herbal combination for three to 32 days. They all had been diagnosed with chronic functional disorders for at least one to 20 years. The symptoms the patients experienced included pressure and pain in the abdomen, belching, heartburn, vomiting, nausea, fullness, lack of appetite, constipation, and diarrhea. The patients have been treated for their problems with a variety of antacids, anti-spasmodic agents, and motility-inducing substances. For the purposes of the study, the patients stopped taking these medications and received treatment only with the herbal combination.

Abdominal pressure and pain in the abdomen was the most common of all the experienced symptoms, with 11 of the patients rating it as severe. After six days of treatment, only sic of the patients continued to rate their abdominal pain and pressure as severe. After two weeks, this symptom had completely resolved for 16 of the patients. Diarrhea had been rated as severe in five of the patients. By day 14, only one patient continued to have moderate diarrhea.

Medications prescribed and taken for cardiovascular diseases, arthritis, and autoimmune diseases often cause gastrointestinal problems. Because these conditions are chronic, these medications must be taken for a long time, often for life. With long-term use, these medications can cause erosion of the stomach lining and actual ulcers. Many of these medication-caused symptoms are similar to IBS symptoms: pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Most, if not all, of the individuals who have gastrointestinal problems caused from medications experience two or more of these IBS symptoms.

Forty patients who were taking medications for various types of cardiovascular disease and arthritis, and who are experiencing gastrointestinal problems related to their medications, were enrolled in a study. These symptoms included pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Twenty patients received clown’s mustard combined with other herbs that support gastrointestinal motility. Three days after the trial started, a significant improvement of all s symptoms was noted in those taking this combination. By day 14, abdominal pressure and pain, nausea, and heartburn were completely eliminated in the herbal combination group. Several other clinical trials that were conducted in Germany report similar results.

Q. How does this herb compare to prescription drugs?

A. A study compared clown’s mustard (combined with other herbs) to Reglan (metoclopramide), which is frequently prescribed to reduce the symptoms of IBS. While metoclopramide is a very effective medication, it also has numerous side effects. Metoclopramide can cause fatigue, anxiety, agitation, jitteriness, insomnia, yellowing of the skin or eyes, changes in vision, hallucinations, and seizures. Because of these serious side effects, metoclopramide must not be taken longer than 12 weeks.

In comparison study, 77 subjects were randomized to receive treatment of either clown’s mustard in a combination with other herbs, or metoclopramide. All subjects had pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. The subjects took 20 drops of their assigned treatment after meals three times daily. The duration of treatment was one to two weeks.

In both groups, a parallel improvement of all symptoms was observed. At no point in the study was a statistically significant difference in symptoms found. Both treatments significantly reduced pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. In short, both metoclopramide and the clown’s mustard herbal combination worked well at reducing the symptoms of IBS.

However, side effects occurred more frequently and severely in the metoclopramide group. Given the lack of Differences noted between the products at reducing symptoms of IBS, it would seem sensible to choose the treatment with the fewest reported side effects and no limits on duration of use.

Q. What evidence supports use of enteric-coated peppermint oil capsules for IBS?

A. Peppermint oil has been shown to relax intestinal smooth muscle. In Great Britain, peppermint oil is currently being prescribed for IBS by physicians and it has been used as a digestive aid and to soothe upset stomachs for generations.

Peppermint oil has also been studied for use in an important examination of the colon. A colonoscopy is a procedure of viewing the interior lining of the large intestine (colon) using a colonoscope, a slender, flexible, hollow, lighted tube about the thickness of a finger. A study published in the New England Journal of Medicine supports the idea that even people who are not at risk for colon cancer should have this test. The American Cancer Society recommends that men and women at average risk of colon cancer should have a colonoscopy every 10 years, beginning at age 50.

During a colonoscopy, individuals are sedated and almost no discomfort is experienced. The insertion of the colonoscope into the rectum and up through the colon causes some spasming. This is a natural and expected event and the physician performing the exam administers medications that effectively reduce the spasms.

A recent study compared the use of peppermint oil and commonly used medications to reduce the colonic spasming in colonoscopy. The peppermint oil was introduced directly into the colon. Effective reduction of colon spasming was observed in 88% of the patients.

In a critical review and meta-analysis of peppermint oil for irritable bowel syndrome published in The American Journal of Gastroenterology, eight randomized controlled trials were identified. The studies collectively showed peppermint oil is superior to placebo in improvement of the symptoms of IBS. Because of the good results of these trials, the authors of the review urged additional study of peppermint oil in IBS.

However, straight peppermint oil is rapidly absorbed into the blood stream from the stomach. In recent studies comparing enteric-coated peppermint oil capsules and non-enteric coated oil, both preparations provided effective symptom relief. However, the studies concluded the enteric-coated capsules delivered the benefit of the peppermint oil directly to the intestines. In the treatment of IBS, enteric-coated supplemental peppermint is most definitely preferred.

In fact, an enteric-coated peppermint oil capsule containing rosemary and thyme is extremely effective in the treatment of IBS. All three of these oils are classified as volatile oils, derivatives found in plants that impart taste and aroma. The combination of peppermint, thyme, and rosemary oils in enteric-coated capsules provides significant relief in IBS-related pain.

Q. Can clown’s mustard and other herbs be taken with enteric-coated peppermint oil?

A. Yes, peppermint oil capsules and clown’s mustard can be used together. However, depending on the symptoms, individuals with IBS may want to start with one supplement and then add the other if needed.

Q. How do consumers find these formulas?

A. Fortunately, herbal combinations containing clown’s mustard and enteric-coated peppermint oil capsules are both available at health food stores, natural product supermarkets, pharmacies, and from health professionals. Most knowledgeable sales personnel and health professionals can direct consumers to the most effective products.

Q. What should customers look for when purchasing peppermint oil?

A. As mentioned before, enteric coating of the peppermint oil is extremely important. The coating prevents the oil from being absorbed in the stomach. The enteric coated-capsule moves through the stomach to the small intestine and eventually to the colon, where it is released for maximum benefit.

Q. What is the dosage for peppermint oil?

A. The German Commission E approved peppermint oil for the treatment of irritable colon. In enteric-coated form, the Commission E recommends 0.6 ml per day. Enteric-coated peppermint capsules are available.

Q. Are there side effects or other contraindications?

A. Sometimes, the enteric-coated peppermint oil capsules may cause a transient burning sensation in the rectum when moving bowls. Reducing the dose will correct this.

Individuals who must refrain from alcohol should not take clown’s mustard in an herbal tincture, which may contain alcohol.

Q. What else can IBS patients do to feel better?

A. Food allergies or food intolerance may be associated with IBS. Dairy products and certain grains may trigger a painful episode of IBS. Determining those foods that initiate the problems and eliminating them from your diet can be very helpful.

Many people report their symptoms occur after a meal. Hyperactivity of the intestine of IBS is the response. Often, the strength of this response after a meal is in direct relation to the number of calories and he amount of fat in the meal. Reducing saturated fat, limiting calories, and increasing fiber intake may be helpful.

Stress also stimulates the intestinal hyperactivity. Relaxation training may reduce some IBS symptoms. Listening to therapeutic audiotapes, hypnosis, counseling, and biofeedback all have been shown to improve the healing response in persons with IBS.

Conclusion

IBS can be painful and frustrating, capable of causing much distress. While currently there is no cure for IBS, the symptoms can be managed. The pain, abdominal discomfort, and bowel problems of IBS all respond well to treatment with the use of key herbs, including clown’s mustard, and enteric-coated peppermint oil. These herbal combinations can be both effective and safe in treating IBS. Clown’s mustard and enteric-coated peppermint oil are both effective front-line natural alternatives for IBS treatment.



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The Power Plant of the Amazon
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Date: March 02, 2007 11:34 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Power Plant of the Amazon

Enzymatic Therapy Amazon Herbs

It may surprise most Americans to know that rainforest plants are the original source for one-fourth of the chemotherapy medications used today. Plants offer a plethora of beneficial compounds, and rainforests contain a superabundance of beneficial plants.

In fact, plant medicines are the most widely used medicines of all types in the world. Over eighty-five percent of the world’s population uses plant and herbal medicines as their primary medicines. That’s 5.1 billion (5,100,000,000) people worldwide! While Americans overwhelmingly use synthetically manufactured pharmaceuticals to cure their ills, the vast majority of Earth’s inhabitants use healing plant medicines instead.

One of the most powerful healing rainforest plant medicines is cat’s claw, or Uncaria tomentosa. This high climbing woody vine grows at the base of tall trees in the Peruvian rainforest. The plant’s claw-shaped thorns latch onto the trees and spiral further upward, nourished by the lush rainforest environment. For over 2,000 years, the Ashaninka, a tribal people of the Peruvian rainforest, have used the root of U. tomentosa to treat illnesses in the tribe, including asthma, bladder infections, infected wounds, arthritis, bone pain, bowel inflammation, and cancer.

Q. I’ve heard about cat’s claw, but what does it do and how do I know which one is right for me?

Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today. One reason that it’s so confusing is there are so many kinds of cat’s claw supplements-there are cat’s claw leaves, cat’s claw bark, and even cat’s claw twigs. While each of these supplements claim to help the immune system, it is the root of Uncaria tomentosa that is proven to impart the true cat’s claw health benefits.

Scientists, who have extensively studied every part of the plant, discovered that extracts made from selected cat’s claw roots possess the healing power to treat and prevent diseases like cancer, rheumatoid arthritis, ulcers and degenerative diseases. In addition, it demonstrates anti-inflammatory, anti-viral and anti-microbial benefits.

Adding to the confusion is the fact that not all Uncaria tomentosa roots actually contain healing properties.

Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. The Ashaninka healers, or sancoshi, are able to actually “see” the good spirits hidden inside the root of the plant before they harvest them.

Some cat’s claw plant roots have the good spirits. Some don’t. If the good spirits are mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no apparent Differences in the plants or the roots to the untrained eye, only certain cat’s claw roots possess the power to heal. And, for a very long time, only the Ashaninka tribal healer seemed to be able to identify them. They call the good spirit cat’s claw Saventaro, or “powerful plant”.

However, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they could “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to be important medicinal compounds called pentacyclic oxindole alkaloids (POAs). Research has learned that POAs provide powerful benefits for the human immune response.

Q. Why are good spirits, or POA’s, good for the immune system?

Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.

Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest m ore bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin that is secreted by macrophages. This macrophage-secreted interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals that are essential to an activated immune system.

POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies. And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T cells, Suppressor T cells, and Killer T cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.

Q. Can cat’s claw and other plants in the rainforest really cure diseases? Isn’t that just folklore?

It’s folk use and modern science combined-plants have long been known for their ability to kill cancer cells. In fact, the National Cancer Institute (NCI) has identified over 3000 plant extracts that can kill cancer cells. More than 70 percent of these plants are found only in the rainforest.

Q. What is it about the rainforest that gives plants like cat’s claw these cancer killing compounds?

Most of the time when we talk about rainforests, we’re talking about the tropical rainforests. While other forests, like the old-growth temperate forests of the Pacific Northwest, also have high rainfalls and tall trees, the tropical rainforests located near the equator are where most plant medicines come from.

The Amazon rainforest in South America is the world’s largest, covering an area about two-thirds the size of the continental United States. Depending on the elevation and distance to the equator the Amazon rainforest receives between 160 and 400 inches of rain per year. The rain is spread pretty evenly from January to December-it’s always the rainy season-and the temperatures remain between 75-80 degrees Fahrenheit all year.

This fertile environment continually recycles itself. When leaves fall from the trees, flowers wilt, and animals die in the rainforest-all of the nutrients are recycled back into the roots of the trees and plants. Because the rainforest reuses almost everything that falls to the ground, the plant growth is amazingly rich in alkaloids and other medicinal compounds. Researchers think these compounds and alkaloids, like POAs, protect the plants from illness and insect attacks. These are the very same compounds that protect us from disease.

Q. When the Ashaninka harvest the cat’s claw roots, does it impact the rest of the plant?

No. The Ashaninka work intelligently to keep rainforest cat’s claw plants perpetually healthy. The Ashaninka employ responsible and innovative harvesting techniques to keep the plants alive and tribal members healthy. Individual cat’s claw plants are never completely harvested. Only one third of the lateral roots are collected at any one time to allow re-growth by the remaining root. Once a plant’s lateral roots have been partially harvested, that plant is left to regenerate, and no more root is harvested from it for 10 years.

Q. Why are the Ashaninka willing to share their cat’s claw?

They are generous people. The Ashaninka see no benefit in hoarding cat’s claw for themselves alone. They also want to make sure that the plant’s healing properties continue on. As their homelands continue to be destroyed by deforestation, rainforest peoples are also disappearing. There were an estimated ten million tribal and indigenous peoples living in the Amazonian Rainforest in 1510. Today there are less than 200,000.

Since the 1900’s more than 90 indigenous tribes have died out and disappeared. Each time a rainforest medicine man or woman dies without passing their arts on to the next generation, the tribe and the world loses thousands of years of irreplaceable knowledge about medicinal plants. With them, centuries of accumulated knowledge of the medicinal value of rainforest species have been lost.

A good example of the impact of this loss can be seen in cat’s claw. When European explorers began venturing into the Amazon River basin, t hey were skeptical of the stories the Ashaninka people told them of U. tomentosa’s amazing healing powers. But when the explorers became sick with colds, flu, or other illnesses, they harvested cat’s claw root for themselves and gave the plant a try. Sometimes the explorers got better when they used the cat’s claw root, sometimes they stayed the same.

Q. Why didn’t the cat’s claw root help all the explorers?

Because some cat’s claw plant roots have good spirits-POAs-and some cat’s claw plant roots have tetracyclic oxindole alkaloids, or TOAs. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all. All U. tomentosa plants look virtually identical, so it’s hard to tell if they have the healing POAs or non-helpful TOAs.

What makes cat’s claw identification even more challenging is the fact that plants with POAs one year will have TOAs the next. Cat’s claw plants seem to change their alkaloid chemotypes at will, an incredibly powerful accomplishment for a plant to possess. Harvesting of cat’s claw roots that contain POAs is very tricky. Unless the person gathering the root extract is an Ashaninka sancoshi. These medicine men know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root. When scientists studying cat’s claw discovered they could “see” presence of TOAs using HPLC technology, they were able to harvest cat’s claw root extracts with POAs that consistently helps people get and stay healthy.

Q. Do some cat’s claw root extract supplements contain TOAs?

Yes they do. And buying those products will only benefit the cat’s claw distributor; they won’t help you stay healthy. When cat’s claw root is harvested from the rainforest, responsible supplement maker examine the root with HPLC to make sure that only POA roots are collected. But, this identification of the chemotypes takes significant time and costs money. For these reasons, many cat’s claw distributors don’t include this important process in their harvesting. The POAs and TOAs are simply just mixed together and sold as a cat’s claw product with no mention of any alkaloid content on the label.

Q. Why should I avoid TOAs?

While the POAs in cat’s claw root extracts have numerous benefits to the immune system, the TOAs have different effects in the body, none helping the immune system cells. Most importantly, however, when POAs and TOAs are mixed together, the TOAs actually work against the POAs. TOAs reduce the capacity of POAs to beneficially modulate the immune system.

Q. How can I be sure the cat’s claw I buy is POA cat’s claw?

Read the label of the cat’s claw root extract product you are considering buying. If it does not clearly state that it is the high POA cat’s claw, then chances are that it’s not.

Q. What do the Ashaninka receive in return for the cat’s claw harvesting?

The Ashaninka and reputable distributors of cat’s claw root extract have established a mutual and ethical relationship. Both groups benefit from the sale of the plant material. Maintaining this relationship is important for both the tribe and the distributors.

The distributors are paying a fair price for the raw material directly to the tribe. No intermediary is involved. This payment covers the raw material itself, a license-fee for the k knowledge of the plant, and a guarantee (from both sides) of a lasting relationship. Payment is also made for the protection of the rainforest. No deforestation is allowed. The area where the cat’s claw materials are processed is also leased and payment is made for this, as well.

This arrangement allows the Ashaninka to make independent decisions in how to spend this income from sale of their cat’s claw plants. They have been able to make improvements in the tribe’s water supply and in their living areas. They are also able to obtain outside medical aid as needed and provide for education of their children.

The partnership with cat’s claw distributors has created a sustainable resource for the Ashaninka. The tribe has been able to not only preserve their rainforest, but also compete financially with unsustainable income sources offered by timber and agricultural firms.

Q. Why is it important to preserve the rainforest?

The most amazing fact about these impressive medicinal plants is the vast number that5 has yet to be discovered. In fact, the rainforest’s abundance is one reason it is home to so many healing plants. Within a four square mile patch of rainforest, you could see 1500 species of flowering plants, 750 species of trees, 125 mammal species, 400 species of birds, 100 reptile species, 60 amphibian species, and 150 different species of butterflies.

Unfortunately, not everyone looks to the rainforest for the same reasons. Many consider its real value in board feet and cultivated acreage. The forces pushing industrial development move quickly; experts estimate that we’re losing over 130 plant, animal, and insect species every day/ That amount to almost 50,000 species a year.

A combination of logging, petroleum interests, cattle grazing operations, and, of course, our own consumer appetites are putting pressure on rainforest resources. The consequences are sobering:

  • Rainforests once covered 14% of the earth’s land surface; it’s only 6% today
  • The last remaining rainforests could be consumed in less than 40 years.
  • Nearly half of the world’s species of plants, animals and microorganisms will be destroyed or severely threatened over the next quarter century due to rainforest deforestation.

By leaving the rainforest intact, however, and harvesting its many nuts, fruits, oil-producing, and medicinal plants, the rainforest has more economic value than if it was cut down for timber or to make grazing land for cattle. If managed properly, the rainforest can provide the world’s need for sustainably harvested natural resources on a perpetual basis. That’s what the Ashaninka are doing with their cat’s claw harvesting.

Conclusion

The discovery of medicinal plants is dependent upon healthy rainforests. When an acre of tropical rainforest is lost due to deforestation, the impact on the number of plant and animal species lost and their possible uses is staggering.

We can all help the development of sustainable rainforest industries. By purchasing renewable and sustainable rainforest products, like POA type cat’s claw root extract, we are keeping rainforests alive and well. By benefiting from the innate wisdom of the Ashaninka people we are keeping ourselves just as alive and well. By honoring the science and the sacred of the world’s rainforests, like my friend the oncology nurse, the massive wealth and diversity will be there for generations to come.



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Q. What is cat’s claw?
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Date: November 22, 2006 01:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Q. What is cat’s claw?

A. Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today-with some fairly good reasons.

First its mere name can be bewildering. Currently, there are at least 16 plants in the world that are called cat’s claw. Sometimes these plants are referred to as “Una de Gato”, Spanish for cat’s claw. While Uncaria tomentosa is the Latin name of the plant most frequently sold as cat’s claw supplements, these products vary vastly. Some cat’s claw nutritional supplements contain cat’s claw bark, some contain cat’s claw stems, and others contain compounds from the leaves of cat’s claw. All of these claim to help the immune system. However, it is the root of Uncaria tomentosa that actually contains the true cat’s claw health benefits. Scientists, who have extensively studied every part of the plant, discovered that only extracts made from cat’s claw root possess the healing power to treat and prevent disease. While it would seem that this vital understanding might help clear up some cat’s claw confusion, not all Uncaria tomentosa roots actually contain healing properties.

To determine which cat’s claw roots do have healing properties, we have to go to the rainforests of Peru. This is where Uncaria tomentosa thrives. It’s a woody vine that’s found at the base of tall trees in the rainforests. As the plant grows, it winds up and around the tree, attaching itself to the trunk with curved cat-like claws found at the junctions of its leaves. The Ashaninka Indians, who make these rainforests their home, have used the roots of the cat’s claw plant for thousands of years to cure illness and maintain health in the tribe.

Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. In order to obtain these healing properties, the correct cat’s claw root must first be harvested. The Ashaninka healers know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root of the plant before they collect them. Some cat’s claw plant roots have the good spirit. Some cat’s claw plant roots don’t. If the cat’s claw root with good spirits is mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no visible Differences in the plants or the roots, only certain cat’s claw roots possess the power to heal. And, only the Ashaninka tribal healers seem to be able to see them.

Amazingly, however, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they were able to “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to actually be important medicinal compounds, called pentacyclic oxindole alkaloids (or POAs).

At the same time, the scientists studying cat’s claw found they could “see” the non-healing properties as well. Again, using HPLC, they also discovered the presence of tetracyclic oxindole alkaloids (or TOAs) in certain cat’s claw roots. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all.

And, if the TOAs and POAs are mixed together (as so often happens in the vast majority of cat’s claw products), the resulting product is useless to healing and health. The TOAs cancel out the action of the POAs, making the cat’s claw root extract ineffective. Even as little as 1% TOA content can cause POAs to lose their ability to beneficially modulate the immune system.

This means that cat’s claw supplements that contain only POAs (in other words, cat’s claw that is 100% TOA-free) from the root of the plant will provide powerful effects in the immune system.

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Enjoy Some Nuts Every Day
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Date: November 03, 2006 04:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Enjoy Some Nuts Every Day

Although high in fat, nuts contain oils that reduce the risk of coronary heart disease. Nuts also contain potentially cardio protective components including phytosterols, tocopherols and squalene. Walnuts, almonds, pecans, Brazil nuts and macadamia nuts were all found to be good sources of these compounds. Diets that included one or two servings of macadamia nuts a day have been shown in studies done in Brisbane Australia and Honolulu Hawaii to improve blood lipid profiles as effectively as low-fat, complex carbohydrate diets. Furthermore, scientists at the Harvard School of Public Health found that eating nuts and peanut butter reduced the risk of type II diabetes in women. The researchers suggest that nuts might replace refined grain products, and red or processed meats as a way to limit caloric intake.

The Lowly Goober Gets New Respect

Americans eat more peanuts and peanut butter than all other nuts combined. A Pennsylvania State University study of 13,000 men, women and children revealed that peanut eaters have higher intakes of several hard-to-get nutrients compared to those who did not consume peanuts. Peanut butter and peanut eaters have increased levels of vitamin A, vitamin E, folate, Calcium, magnesium, zinc, iron and phytonutrients resveratrol, beta sitosterol and p-courmaric acid. What’s more, peanut eaters also had leaner bodies than non peanut eaters. This study helps to dispel the myth that higher-fat foods automatically lead to weight gain.

The peanut Butter Diet evolved from studies such as this that showed the benefits of eating peanuts and peanut butter, particularly their high satiety factor. In one small study, ten health workers aged fifty-plus, consumed 1500 calories healthy and moderate fat (35%) diet that included two tablespoons of peanut butter eaten twice a day. The woman had at least one cardiovascular risk factor – high blood pressure, altered blood lipids or diabetes. Peanut butter was chosen because previous studies at Harvard/Brigham Women’s hospital had shown that over an eighteen-month period, three times as many women stuck with a diet that included peanut butter or peanuts, because of a hunger curbing effects.

Peanuts contain about 2 grams of fiber per tablespoon and when spread on two slices of whole-wheat bread, deliver six grams of fiber. Peanut butter makes some yummy sauces. The barbecued ribs a group of scientists and I prepared during a recent weekend at the Culinary Institute of America Greystone in California’s Napa Valley where the best I have ever eaten.

Tropical Oils

The term refers to coconut, palm kernel and palm oils. These oils contain a variety of fatty acids, but unlike olive, macadamia and peanut oils, which contain high levels of unsaturated fatty acids and are liquid at room temperature; tropical oils have high levels of saturated fats and are solid at room temperature. They are gaining popularity as food manufacturers push to replace hydrogenated oils that contain trans fats. The latest hoopla over coconut oil has been its inclusion in weight loss regimens. Two books featuring coconut products have hit bestseller lists. Moderate increase of tropical oils including coconut and palm appear to improve blood lipid profiles largely because of their high lauric acid content.

The health benefits of medium chain triglycerides (MCTs) such as caprylic and lauric have been known for some time. Lauric acid has been found to improve blood lipids and red palm oil is rich in antioxidants such as beta-carotene and tocotrienols, the vitamin E active constituent. However, there is concern among some experts that eating to many saturated fats, including the tropical oils used to make trans fat free margarine and shortening, can have deleterious effects on cardiovascular health.

In addition, there are Differences in processing palm and palm kernel oils that make some choices unhealthy. According to Dr. Andrew Weil palm oil is a better choice than palm kernel oil because chemical solvents are needed to extract palm kernel oil while none are required to press the oil from palm fruit. Fractionation is used to process palm and palm kernel oil and eliminates many of their natural antioxidants, which makes them the least desirable of the tropical oils. It seems prudent to check ingredient labels for fractionated palm kernel oil and avoid it. Best of all, look for Now Organic Coconut Oil that has an impressive resume for boosting immunity. It also has a distinctive flavor to foods prepared with an eastern Indian theme.

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Benefits of L-Carnitine
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Date: February 12, 2006 03:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of L-Carnitine

Benefits

Helps the body burn fat for energy*

L-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion. Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine. The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body's L-Carnitine content is stored in the form of acyl-carnitine.1

The mitochondrion is the cell’s energy-generating furnace. Called an “organelle,” the mitochondrion is a self-contained structure inside the cell. Like all cellular structures, the mitochondrion is surrounded by a membrane. This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter. On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation. One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.” L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.

Evidence suggests that L-Carnitine and short chain acyl-carnitine esters can protect the mitochondrion from adverse effects of drugs and toxic chemicals. L-Carnitine has been shown to protect animals form cardiotoxins and decrease mortality rate in animals with diphtheria, due to this cardioprotective effect.2

Helps maintain a healthy heart and cardiovascular system*

Muscle tissue contains a high concentration of L-Carnitine. With its constant energy needs, heart muscle tissue is especially rich in L-Carnitine. If the body’s ability to biosynthesize L-Carnitine is compromised, energy production in muscle tissue is impaired, and a toxic buildup of fatty acids can occur.3 Defective production of L-Carnitine by the body can result from a variety of factors, including kidney or liver malfunction, increased catabolism or the inability of tissues to extract and retain L-Carnitine from the blood.

Along with glucose and lactate, fatty acids are the primary oxidation fuel for the heart. A considerable amount of scientific data from animal experiments indicates that L-Carnitine protects the heart under conditions of hypoxia, or low oxygen. In addition to the oxidation of fat for energy in the cell, L-Carnitine is involved in the metabolism of glucose.4 Evidence of L-Carnitine’s role in glucose metabolism was uncovered in a small trial on 9 diabetic individuals. Given intravenously, L-Carnitine improved insulin-mediated glucose utilization and insulin sensitivity.5

Depletion of the body’s L-Carnitine supply is linked to various abnormal states, especially of the heart muscle. The effect of L-Carnitine on hypoxic (oxygen-starved) isolated heart muscle tissue has been studied.6 At high concentrations, L-Carnitine demonstrates a clear-cut ability to potentiate the contractility of isolated heart muscle tissue, indicating the L-Carnitine has a strengthening effect on the heart. L-Carnitine has been shown to improve the performance of rats subjected to fatigue test.

Research has revealed that in animals and humans with defective heart muscle, the amount of free L-Carnitine (not bound to fatty acids) is reduced. Administration of L-Carnitine to hamsters prevents damage to the heart muscle. Given to humans with angina, L-Carnitine was found to improve exercise tolerance. In a small study, patients with congestive heart failure showed gains in heart function with oral consumption of L-Carnitine, reportedly by restoring normal oxidation of fatty acids.7 In heart valve replacement patients, L-Carnitine has been shown to increase the valve tissue levels of ATP, pyruvate and creatine phosphate, which are key cellular energy substrates. In a controlled study, L-Carnitine was administered to 38 patients prior to open heart surgery. Prior to surgery, heart circulatory function, as assessed by measurements of hemodynamics, was “good” in all 38. While there was evidence of a “preserving” effect of L-Carnitine on heart cells, no Differences in cardiac performance were observed. These results suggest that noticeable improvements in heart muscle performance with L-Carnitine are most likely to occur in people with compromised hearts.8

It has been suggested that L-Carnitine favorably influences blood lipids. Preliminary evidence of this was seen in a small open trial on 26 patients who took 3 grams of L-Carnitine daily for 40 days. Blood levels of cholesterol and triglycerides dropped substantially, while the ratio of total to HDL cholesterol–– a known marker of cardiovascular health––markedly improved.9

While L-Carnitine is not a treatment for heart disease, (nor should it be used as a substitute for medical treatment) the results of these and other studies suggest that oral consumption of L-Carnitine has a beneficial influence on maintaining a healthy heart and cardiovascular system.



Safety

Suggested Adult Use: Take 1 to 4 capsules daily without food.

L-Carnitine is considered to be very safe for oral consumption. L-Carnitine is generally well tolerated, even at doses as high as 15 grams daily. Toxicity or overdosage has not been reported.10



Scientific References
1. Wagenmakers, A. L-Carnitine supplementation and performance in man. Brouns, F. ed. Advances in Nutrition and Top Sport. Med Sport Sci. Basel, Karger, 1991;32:110-27.
2. Arrigoni-Martelli, E., Caso, V. Carnitine protects mitochondria and removes toxic acyls from xenobiotics. Drugs Exptl. Clin. Res. 2001;27(1):27-49)
3. Pepine, C.J. The therapeutic potential of carnitine in cardiovascular disorders. Clinical Therapeutics 1991;13(1):2-21.
4. Calvani, M., Reda, E., Arrigoni-Martelli, E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Research in Cardiology 2000;95(2):75-83.
5. Capaldo, B. et al. Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients. Diabetes Research and Clinical Practice 1991;14:191-96.
6. Fanelli, O. Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties. Life Sciences 1978;23:2563-2570.
7. Kobayashi, A., Masumura, Y., Yamazaki, N. L-Carnitine treatment for congestive heart failure-experimental and clinical study. Japanese Circulation Journal 1992;56:86-94.
8. Pastoris, O. et al. Effect of L-Carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing heart surgery. Pharmacological Research 1998;37(2):115-22.
9. Pola, P. et al. Carnitine in the therapy of dyslipidemic patients. Current Therapeutic Research 1980;27(2):208-16.
10. L-Carnitine. PDR for Nutritional Supplements. First Ed. 2001.Montvale, NJ:Medical Economics.



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Omega-3’s Fight Postpartum depression
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Date: January 23, 2006 02:42 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Omega-3’s Fight Postpartum depression

Omega-3’s Fight Postpartum depression

Tucson, AZ—Marine-sourced omega-3 essential fatty acids (N-3 EFAs) combat postpartum depression (PPD), according to a study published online in acta Psychiatrica Scandinavia (www.blackwell-synergy.com).

In the eight-week trial, test subjects were randomized to receive 0.5 g/d (n-6), 1.4 g/d (N-3) or 2.8 g/d (n-7) n-3 EFAs (as EPAX omega-3 oil provided by Epax AS, Previously a division of Pronova Biocare AS [www.provona.com]). All groups had reductions in mean scores on Edinburgh Postnatal and Hamilton Rating depression scales (51.5 percent and 48.8 percent, respectively); changes from baseline were significant within each group and when combining groups. The researchers concluded results of the study support further study of n-3 fatty acids as a treatment for PPD.

“Omega-3 fatty acids were assessed in a double-blind dose-ranging trial,” said Marlene Freeman, M.D., director of the Women’s Mental Health Program and assistant professor of Psychiatry, Obstetrics & Gynecology, and Nutritional Sciences at the University of Arizona College of Medicine. “A combination of omega-3 EPA and DHA fatty acids provided by EPAX AS was utilized. Among all three doses, patients with postpartum depression improved substantially during the trial. Scores on depression measures decreased by approximately 50 percent and Differences were statistically significant.”



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Your Cells Supercharge Your Cells
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Date: December 20, 2005 11:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Your Cells Supercharge Your Cells

Your Cells Supercharge Your Cells

The Differences between aging and growing old are poles apart. Sure, they may sound similar in nature. But when you think about it, the two are as different as night and day. Growing old is about retirement and travel and enjoying what you’ve worked an entire life for. Aging, on the other hand, summons images of wrinkled skin, brittle joints, cloudy minds and medicine cabinets full of prescriptions. It’s safe to assume that the majority of us want to look, live, and feel better as we grow old. Not the opposite. Many of us are on the right track - committed to a healthy lifestyle that includes regular exercise and a well-balanced diet. And yes, these do serve as a solid foundation for good health during our golden years. It is our cells, however, that ultimately determine who grows old, and who just ages.

Still, slowing the proverbial hands of time is not all about health clubs and organic produce. If you want to grow old gracefully, you must nurture the ten trillion cells that defi ne you physically. Why? Because these cells are constantly under attack by free radicals - unstable molecules that either lack, or have an unpaired number of electrons. They scour the body in search of stable cells, and do whatever they can to rob them of their electrons, a process more formally known as oxidation. Considering that it’s environmentally impossible to completely avoid contact with the billions of airborne toxins that cause free radicals, the only other option is to safeguard your healthy cells. Making the commitment to a healthy lifestyle is the fi rst step in the process, and can be accomplished by eating healthier foods, exercising on a regular basis, and paying close attention to what you are exposed to environmentally.

The next step is to nourish and protect your cells. The best way to do this is to consume foods that are rich in antioxidants and other cell-friendly nutrients. Unfortunately, this task is often much easier said than done. Today’s average adult is busier than ever, making it far more diffi cult to consume fresh, unprocessed meals 100% of the time. This does not, however, imply that all hope is lost. Over the years, the nutritional sciences have made stunning advances that afford you the opportunity to live your life while still safeguarding the integrity of your most basic building blocks. Here are a few of the best.

Antioxidants

Antioxidants work at the cellular level to paralyze the free radicals that cause oxidation throughout the body. Some of today’s most popular nutrients and dietary supplements fall into this category. They include vitamins A, E, and C, Selenium, Zinc, Alpha Lipoic Acid, Lycopene, Lutein, CoQ10, in addition to a host of others. And though similar in function, each of these free radical fi ghters has a unique role within the body.

Take CoQ10 for example. It’s present in every cell of the body, and is especially important for cardiovascular support. Lutein has been used extensively to prevent oxidation in the macular regions of the eyes. Zinc is a powerful immune system booster that has become extremely popular during cold and fl u season. Alpha Lipoic Acid is both fat and water soluble, and is commonly referred to as the “universal” antioxidant based on its ability to quench free radicals anywhere in the body.

Immune Boosting Herbs

Herbs such as Astragalus, Olive Leaf, Rhodiola, Echinacea, Panax Ginseng and Ashwaganda have been used for centuries to help support healthy cells and strong, responsive immune systems. They’ve also been shown to exhibit natural synergistic effects when used together. Today, they remain one of the most popular ways to naturally promote all-around wellbeing. When it comes to supporting healthy cells, NOW is pleased to offer one of the best selections of antioxidants, herbs and immune support formulas. Be sure to look for these and other great products at fi ne health food retailers, nationwide.*

OPCs

OPCs (proanthocyanidins) are high-powered polyphenol antioxidants that belong to the fl avonoid family. Grape seed extract, pine bark extracts such as pycnogenol and enzogenol, bilberry, gingko biloba, resveratrol and others all fall into this category. Research continues to suggest that OPCs work in the same manner that traditional antioxidants do, however their ability to eradicate free radicals is much greater and more versatile. Equally appealing, OPCs can easily cross the blood barrier of the brain to help protect brain and neural tissues from the damage caused by oxidative stress.

Mushroom Extracts

Throughout history, many civilizations have relied on organic mushroom extracts to encourage wellness. What we know now is that mushrooms such as Shiitake, Maitake, Reishi and others are rich in 1,3 Beta-glucans - soluble fi ber compounds that help support both innate and adaptive immunity. In addition, the active compounds in some mushrooms have been shown to stimulate the production of microphages, T cells, and other natural killer cells. These biological warriors serve at the front line when it comes to responding to bacterial attacks. They are of immeasurable value to the immune system, though drastically lacking in today’s average diet. In just the past few years, more and more healthconscious individuals have learned fi rst-hand how benefi cial they can be in the preservation of healthy cells.



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What is cat’s claw?
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Date: November 11, 2005 05:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is cat’s claw?

Q. What is cat’s claw?

A. Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today-with some fairly good reasons.

First, its mere name can be bewildering. Currently, there are at least 16 plants in the world that are called cat’s claw. Sometimes these plants are referred to as “Una de Gato”, Spanish for cat’s claw. While Uncaria tomentosa is the Latin name of the plant most frequently sold as cat’s claw supplements, these products vary vastly. Some cat’s claw nutritional supplements contain cat’s claw bark, some contain cat’s claw stems, and others contain compounds from the leaves of cat’s claw. All of these claim to help the immune system.

However, it is the root of Uncaria tomentosa that actually contains the true cat’s claw health benefits. Scientists, who have extensively studied every part of the plant, discovered that only extracts made from cat’s claw root possess the healing power to treat and prevent disease. While it would seem that this vital understanding might help clear up some cat’s claw confusion, not all Uncaria tomentosa roots actually contain healing properties.

To determine which cat’s claw roots do have healing properties, we have to go to the rainforests of Peru. This is where Uncaria tomentosa thrives. It’s a woody vine that’s found at the base of tall trees in the rainforests. As the plant grows, it winds up and around the tree, attaching itself to the trunk with curved cat-like claws found at the junctions of its leaves. The Ashaninka Indians, who make these rainforests their home, have used the roots of the cat’s claw plant for thousands of years to cure illness and maintain health in the tribe.

Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good sprits” that live in the plant’s roots. In order to obtain these healing properties, the correct cat’s claw root must first be harvested. The Ashaninka healers know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root of the plant before they collect them. Some cat’s claw plant roots have the good spirits. Some cat’s claw plant roots don’t. If the cat’s claw root with good spirits is mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no visible Differences in the plants or the roots, only certain cat’s claw roots possess the power to heal. And, only the Ashaninka tribal healers seem to be able to see them.

Amazingly, however, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they were able to “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to actually be important medicinal compounds, called pentacyclic oxindole alkaloids (or POAs).

At the same time, the scientists studying cat’s claw found they could “see” the non-healing properties as well. Again, using HPLC, they also discovered the presence of tetracyclic oxindole alkaloids (or TOAs) in certain cat’s claw roots. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all.

And, if the TOAs and POAs are mixed together (as, so often happens in the vast majority of cat’s claw products), the resulting product is useless to healing and health. The TOAs cancel out the action of the POAs, making the cat’s claw root extract ineffective. Even as little as 1% TOA content can cause POAs to lose their ability to beneficially modulate the immune system.

This means that cat’s claw supplements that contain only POAs (in other words, cat’s claw that is 100% TOA-free) from the root of the plant will provide powerful effects in the immune system.



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Definition of Green Tea.
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Date: November 05, 2005 03:28 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Definition of Green Tea.

Definition

Green tea is derived from the leave of a plant called camellia sinensis. The leaves are processed and used to make tea.

Green, black and oolong teas are all sourced from camellia sinensis. The Differences in processing determine which kind of tea the leaves become.

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Your emotions, your thoughts may effect your health...
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Date: August 09, 2005 03:10 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Your emotions, your thoughts may effect your health...

Your emotions, your thoughts May effect your health

Concerning the supposed connection between positive emotions and overall health, many feel that, well, they’re not so connected. It is interesting to note that they’d be right—and wrong. The way we think and feel has a definite correlation to our health; in other words, our bad thoughts and emotions may affect us in the same manner as our good ones. In a recent study at Duke University, a research professor discovered that high levels of hostility have been shown to lead to an increased susceptibility of coronary disease by the age of 50.

These “hostile” people are four to seven times more likely to have coronary problems, mainly due to the stress the hostile emotions put on their body. Negative thoughts and feelings can affect the state of your health, usually in the form of stress.

“A group of researchers found that the number of ill-nesses suffered decreased as peopl e had mor e positive thoughts, including a relief.”

On the other hand, a group of researchers found that the number of illnesses suffered decreased as people had more positive thoughts, including a relief from stress-based illnesses. The negative thoughts were thought to be a factor contributing to these people’s decreased state of health, and as the “bad thoughts” lessened and the “good thoughts” increased, the overall state of health seemed to improve. Ultimately, your health and mood are connected—they influence one another. The brain and the nervous system work hand in hand, and any Differences in the levels of hormones and neurotransmitters can affect your mood positively and negatively. One timeproven method for fighting off a bad mood is exercise. Exercise stimulates a release of endorphins, which work to improve your mood and alleviate stress.



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Energizing Intimacy - The foundation of a loving relationship is built on communication
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Date: July 27, 2005 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Energizing Intimacy - The foundation of a loving relationship is built on communication

Energizing Intimacy

The foundation of a loving relationship is built on communication.

Mars/Venus. He said/she said. Action movies/chick flicks. However you choose to characterize Differences between the sexes, one this is clear: We tend to see men and women as irreconcilable opposites, people who need each other deeply yet who often don’t know how to live with one another. The stress that ensues when the love connection breaks down aches not only our hearts but the rest of our bodies as well…to say nothing of what it teaches our children about the nature of relationships.

This issue of Energy Times is primarily devoted to offering advice and guidance on how to rebuild that love connection; how committed, loving couples can energize intimacy in their relationships. You can find valuable information in stories on the incredible herbs around the world that aid and enhance libido; tips on how women can use natural cosmetics to rev up a partner’s sexual engine; and how couples can create passion in the kitchen, through mutual back massage and after menopause.

But those articles offer little help if the foundation of your relationship is not primarily built on communicating your needs and desires- whether inside or outside of the bedroom- and listening, really listening, to the other person in your life. Communication is the holistic way to view sexual health and healing because having a clear understanding with your partner about love and life is the way your relationship can truly be whole.

With our national divorce rate hovering around the 50% mark, it is clear that American adults still have an immense learning curve when it comes to talking about sex and intimacy. Sensual images and situations bombard us from books, television, films and Internet sites, yet we seem to be as clueless as ever, not knowing how to talk intelligently about intimate relationships to each other or to our children.

Part of the problem stems from the constant barrage of verbal and visual messages- whether from our parents, friends or corporate advertising- that make us incredibly self-conscious about sensuality and our bodies. Many women fight to come to terms with self-images of their bodies as not thin or beautiful enough, while a lot of men struggle to overcome fear and insecurity over their sexual prowess. Carrying such baggage around can’t help but negatively affect the way people relate in a relationship. After all, before you can share love with your partner, you must learn to love yourself.

We also have to overcome the energy flows that start getting blocked during childhood, when we learn to restrain our emotional energy for the sake of fitting in. Like water behind a crumbling dam, though, repressed energy leaks out in all sorts of extremely unhealthy ways: Anger, depression, irritability, stress- and sexual dysfunction.

Learning to Talk

According to Chris Frey, a Missouri-based psychotherapist and pet who has studies sexual relationships, our culture does a great job reaching people about the mechanics and “how-to” of intimacy and the dangers of unprotected sex, but few families or institutions talk about healthy sexuality with a partner.

“Culturally, the prevalent myth still is that loves means intuitively knowing what my partner wants,” Frey said in an interview posted on the website of the Missouri Lawyer Assistance Program (MOLAP). “People think if they have to talk, or worse yet, ask about it, then there must be something wrong with them. That’s incorrect. Instead of open communication, people often turn to innuendo, humor and guesswork. When couples break through that, the sensitivity and intimacy built as two uncertain people begin to communicate about sex builds an amazing amount of trust, and most likely, a much more pleasurable relationship.”

In fact, trust is a key part of a model of healthy sexuality developed by social worker, marriage and family therapist and author Wendy Maltz. Called CERTS, Maltz’s model requires that five basic conditions be met for a healthy sexual relationship: Consent, Equality, Respect, Trust and Safety.

  • • Consent means you can freely and comfortably choose whether or not to engage in intimate activity and you are able to stop the activity at any time during the contact.

  • • Equality means your sense of personal power is on an equal level with your partner. Neither of you dominates the other.
  • • Respect means you have positive regard for yourself and for your partner. You feel respected by your partner.
  • • Trust means you trust your partner on a physical and emotional level. You have mutual acceptance of vulnerability and an ability to respond to it with sensitivity.

  • • Safety means you feel secure and safe within the intimate setting. You are comfortable with and assertive about where, when and how the intimacy takes place. You feel safe from the possibility of harm, such as unwanted pregnancy, sexually transmitted infection and physical injury. According to Chris Frey, it is only when the CERTS model-what he calls “the attitudes of healthy sexuality”-exists as a foundation in the relationship that you can build on those attitudes with behaviors such as romance, affection, intimacy and sensuality. “The CERTS model is a guide for being more mature and loving in any adult relationship: marriage, dating, friendship. The opportunities to move away from shame, miscommunication, exploitation and confusion are all present in this information. In Sexuality, CERTS is the work for an advanced course in having a healthy relationship. In life, CERTS is simply a great guide for how we can choose to interact with one another.” Once a couple achieves wholeness through communication, they can spend the rest of their lives exploring the limitless sensual possibilities.
    -Steven Hanks and Lisa James



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    WHAT EXACTLY IS PYCNOGENOL?
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    Date: July 13, 2005 09:42 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: WHAT EXACTLY IS PYCNOGENOL?

    WHAT EXACTLY IS PYCNOGENOL?

    Pycnogenol is a super antioxidant which consists of a highly bioavailable flavonoid called proanthocyanidin. This compound can be extracted from either pine bark or grape seed, and both sources are virtually identical. Biochemists will confirm that as a class, the proanthocyanidin bioflavonoids, regardless of their source, possess the same biochemical activity with very slight exceptions.

    The Differences lie in the varying concentrations of the flavonoid and its purity. Extraction processes for each source d i ffer and may contribute to the cost of the type of Pycnogenol in question. Regardless of its source, Pycnogenol has demonstrated extraordinary antioxidant capabilities.

    NATURE’S BEST DEFENSE AGAINST FREE RADICALS: ANTIOXIDANTS

    Potent substances called antioxidants, which scavenge for dangerous free radicals, afford us the best prospect for disease prevention, toxin protection and sustained longevity and vigor. According to many experts, making sure we arm our cellular systems with adequate supplies of antioxidants should be our first health priority. “It has now been established that more than 60 human diseases involve free-radical damage, including cancer, heart disease and the acceleration of the aging process. All that you really need to know is that your body is under constant free - radical atta ck, and that you need to keep your antioxidant defenses strong.”1 The role of Pycnogenol as an exc e ptional free radical scavenger is just beginning to emerge, and the protective potential of Pycnogenol is impressive, to say the least. It’s only a matter of time before scientific data supports the fact that this family of nutrients is far more effective in its antioxidant capacity than previously assumed.

    OTHER ANTIOXIDANTS

    Some of the most common of free radical scavengers or antioxidants include:

  • • Vitamin E
  • • Vitamin C
  • • Vitamin A and Beta Carotene
  • • Coenzyme Q-10
  • • Selenium

    While all of these are excellent cellular protectants, the compound missing from the above list may be the most remarkable of all.

    PYCNOGENOL: THE HERCULES OF ANTIOXIDANTS

    Pycnogenol provides some of the most potent compounds known to nutritionally support and potentiate the body’s defense system against oxidants. Continually emerging research supports the fact that Pycnogenol may be the best antioxidant nature has to offer. In this regard, it is 50 times more potent than vitamin E and 20 times more so than vitamin C.2 Pycnogenol is considered by some health experts to be the greatest nutritional breakthrough of our century.

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    Bio-Chelation
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    Date: June 29, 2005 05:38 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Bio-Chelation

    Bio-Chelation* By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt In The Beginning The Bio-Chelated¨ process describes a proprietary cold extraction technique developed by Mr. Frank D'Amelio Sr., founder and owner of Nature's Answer¨, and well- respected author*. Long before Nature's Answer¨ was formed (early 1970's), Mr. D'Amelio was immersed in the study of botanical medicine, researching the various herbal texts including the national USP/N.F. (United States Pharmacopeia/National Formularies) dating back to the mid -1800's. (The USP/N.F. is a reference source that provides manufacturing standards and extraction techniques used to make herbal formulas; these standards were considered official prior to 1938.) This authoritative formulary discussed the use of plant parts such as leaf, stem, bark, flowers and roots. It recommended certain solvents known as "menstruums", in which plant parts were soaked in order to extract their active constituents. High heat was also often utilized to concentrate the extract. Mr. D'Amelio noticed that high amounts of solvents, usually alcohol, were often recommended, and that sediment would fall to the bottom (precipitate) in certain solutions. He began to investigate how he could offer the consumer potent herbal products made with very low heat, with minimum precipitation, and without a lot of alcohol!

    A Clue From Nature In working towards the goal of attaining a final botanical extract product with little alcohol, Mr. D'Amelio turned to Nature for the apparent answer. He realized that plants were composed of 80-85% water as well as some alcohols, fats, etc. If plants were able to keep the active constituents in solution and use them as needed mainly through water, not alcohol or other solvents, why couldn't he? Thus, he began a long, in-depth series of experiments with many different plants. Through rigorous research protocols and scientific testing, he discovered that the active constituents of some plants could be extracted using lower alcohol amounts with water and other natural solvents such as organic apple cider vinegar or vegetable glycerine. At other times, however, higher alcohol was necessary, such as when he was extracting volatile oils like menthol from peppermint. The experimentation process continued, with Mr. D'Amelio documenting the optimum menstruum combinations required for each plant to yield the maximum beneficial components. (Note that there are Differences in alcohol. The alcohol consumed in wine and beer is derived through a natural fermentation process with no processing other than filtration. When distilled alcohol is added to an extraction, which some herbal manufacturers use, it effects the body in a more detrimental way; thus the development of the Bio-Chelation¨ process, which uses only organic alcohol).

    The Bio-Chelated¨ Method Is Developed As Mr. D'Amelio continued his experimentation with various plants and menstruums, his extraction processes became more refined, and eventually led to the development of the Bio-Chelated¨ method. The Bio-Chelated¨ method incorporates soaking for a period of time, using different menstruum ratios for different plants to optimize their therapeutic values. Furthermore, this procedure offers additional significant advantages when compared with other types of extraction processes commonly employed by competitors in the herbal industry.

    Bio-Chelation includes the use of "cold extraction", where the plant parts are extracted without being exposed to excessive amounts of heat. Cold extraction helps the herb maintain vital minerals and other trace elements in solution, thus enabling the herb to keep its Holistic Balanceª intact. (Holistic Balanceª means that extracts retain as many of the natural constituents of the original plant as possible.) In addition, the Bio-Chelated¨ process incorporates the use of an exclusive technique that removes much of the alcohol used during the menstruum soaking (maceration) phase, replacing it with vegetable glycerin instead. The resulting yield is an herbal extract that is either alcohol-free, or has a low alcohol content. (Both alcohol-free and low alcohol products from Nature's Answer feature vegetable glycerin only. Glycerin is used because it helps bind certain plant constituents, is natural to the body, is easily absorbed by the cells and has little insulin response. Only vegetable glycerin has been used since 1972. In addition, all alcohol used in Nature's Answer's low alcohol formulas is certified organic.)

    The Bio-Chelated¨ method was the first extraction process to yield a 12-14% alcohol extract in the herbal industry!

    Nature's Answer Stands The Test of Time Over the last quarter of a century (since 1972), the Bio-Chelated¨ cold extraction process has been painstakingly tested and proven to stand the test of time. Incorporating Mr. D'Amelio's proprietary cold extraction process in today's manufacturing procedures continues to yield a measurably superior product. One such example is Saw Palmetto from Nature's Answer¨, a product that is produced utilizing our Bio-Chelated¨ method versus the more expensive CO2 method. Our Bio-Chelated¨, cold extraction process yields a product that not only contains the same amounts of active constituents as the more expensive CO2 extracted product, but features a higher percentage of polyphenols, the compounds responsible for the herb's antioxidant properties. The end result is a Saw Palmetto extract that maintains its holistic balance! (Note that most prior successful studies done on Saw Palmetto utilized grain alcohol extracts which contained naturally occurring polyphenols; the CO2 extracted products do not contain polyphenols!) Although larger quantities of herbal products are now being produced as compared to the earlier experimental batches made by Frank D'Amelio, his founding corporate philosophy remains intact - combine the greatest care with the highest quality of raw material to create the ultimate herbal extract that works. After all, that's what it's all about, isn't it? Bio-Chelated¨..Another reason to count on Nature's Answer Without Question! Manufacturing Highlights:

    State-of-The-Art Laboratory Manufacturing Equipment HPLC, UV, IR, GC/MS, LC/MS, TOC and Densitometer 316 Pharmaceutical Grade Stainless Steel or Glass Lined Extraction Vessels (instead of the inexpensive, more commonly used plastic or polyethylene extraction vessels; these vessels are porous and may contain microorganisms, residual plasticizers that are difficult to clean and could cross contaminate different batches of herbs) FDA Registered & Pharmaceutically Licensed cGMP and SOP Compliant Manufactured in the U.S.A. *Botanicals - A Phytocosmetic Desk Reference (1999), Botanical & Herbal Folklore (1974), The Botanical Practitioner (1978) Bio-Chelated¨ is a registered trademark of Bio-Botanica Inc.¨ Holistic Balanceª is a trademark of Bio-Botanica Inc.¨

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    CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness
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    Date: June 29, 2005 01:48 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness

    CHOLESTEROL RESCUE

    You live in a fat-drenched, fast food world, propped up by diets loaded with processed foods that stimulate your body to create excess bad cholesterol – or low-density lipoproteins (LDL). Your busy life is full of stress, and devoid of time for proper exercise. There are three ways to deal with cholesterol in the body, but a seemingly infinite number of lifestyle and hereditary elements that affect LDL levels. Is it any wonder you find yourself in danger of developing unwanted cholesterol levels? Source Naturals is devoted to helping you. So we developed CHOLESTEROL RESCUE as a comprehensive solution to help you keep cholesterol levels in the normal range. CHOLESTEROL RESCUE uses only natural ingredients, clinically researched to effectively maintain healthy cholesterol levels. It is scientifically formulated with the triple action of three ingredients that target the ways you can deal with your cholesterol concerns; combining the naturally occurring polymethoxylated flavone (PMF) and tocotrienol action of Sytrinol™ with the action of plant sterols. Research suggests that daily consumption of 800 mg of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease. Source Naturals offers CHOLESTEROL RESCUE as part of our ongoing commitment to providing you with high quality natural supplements to support your healthy lifestyle.

    Cholesterol & Your Body

    On average, humans ingest approximately 300mg of cholesterol per day. Though an important part of a healthy body, a high level of cholesterol in the blood might be out of the normal range. Cholesterol is transported in your system by lipoproteins. There are two kinds of lipoproteins in your body, but the low-density lipoproteins, or LDL, are the major factors in developing unwanted cholesterol levels. If there are high levels of LDL circulating in your bloodstream, it can undergo oxidation by free radicals in the artery walls, which can then become trapped as imbalanced deposits. These deposits can build up, reducing critical blood-flow. CHOLESTEROL RESCUE has been specially developed to reduce LDL levels using two different methods: inhibiting the synthesis of cholesterol in the liver, and reducing the absorption of dietary cholesterol.

    The Plant Sterol Effect

    Sterols are an essential component of the cell membrane, and are produced by both plants and humans. While the most common sterol produced in humans is cholesterol, plants produce phytosterols, or plant sterols. Using a complex compound of plant sterols similar to cholesterol with only slight molecular Differences, CHOLESTEROL RESCUE has been formulated to balance the amount of dietary cholesterol your body absorbs.

    Plant sterols have long been known to inhibit the uptake of both dietary and bile-produced cholesterol in the intestines. The most plausible theory behind this is that, because of the similarity between plant sterols and cholesterol, the body cannot properly distinguish between the two during the absorption process, thereby displacing the uptake of cholesterol into your system. Research suggests that daily consumption of 800mg of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease.

    Sytrinol™ For Heart Health

    CHOLESTEROL RESCUE also contains SYTRINOL™, a proven natural alternative for maintaining cholesterol wellness. The patented blend of citrus polymethoxylated flavones (PMFs) and tocotrienols has been clinically shown to promote cardiovascular health by supporting normal cholesterol production by your liver, helping balance triglyceride production, and providing powerful antioxidant protection. The PMFs promote normal cholesterol levels by inhibiting both the production of cholesterol precursors, such as cholesteryl esters, and the activity of HMG CoA Reductase, an enzyme that synthesizes cholesterol in the liver. These PMFs can also balance the body’s production of triglycerides by inhibiting your liver’s triglyceride producing enzyme, diacylglycerol acetyltransferase. Tocotrienols help break down cholesterol building blocks, interfere with cholesterol production, and provide critical antioxidant protection. Because cholesterol becomes problematic when oxidized, the powerful antioxidant action of tocotrienols can help prevent the conditions that may affect your cardiovascular circulation.

    Spearheading the Wellness Revolution in Cholesterol Defense

    With so many ways to develop undesirable cholesterol levels in your body, you need to be proactive in maintaining your good health. In our on-going dedication to your wellness, and a commitment to delivering the benefits of our high quality supplements to the natural products marketplace, Source Naturals has produced a scientifically formulated blend of three effective ingredients in fighting unwanted cholesterol. Combining a comprehensive formula of allnatural components, clinically researched for promoting cardiovascular health, CHOLESTEROL RESCUE is available now at your local health food store.

    References
    Guthrie N, Kurowska EM. Anticancer and Cholesterol-lowering activities of citrus flavonoids. Handbook of Nutraceuticals and Functional Foods. (Wildman, R.E.C., ed), CRC Press, Boca Raton, FL. 2001. 113-126. Packer L, Weber SU, Rimbach G. Molecular aspects of alphatocotrienol antioxidant action on cell signaling. Symposium: Molecular Mechanisms of Protective Effects of Vitamin E in Atherosclerosis. American Society for Nutritional Sciences. 2001. 131:369S-373S. Hicks KB, Moreau RA. Phytosterols and phytostanols: functional food cholesterol busters. Food Technology. 2001. 55:63-67. Middleton Jr E, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Review. 2000. 52:673-751. Child P, Kuksis A. Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro. Journal of Lipid Research. 1983. 24: 1196-1209



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    Ginseng Varieties
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    Date: June 25, 2005 12:56 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Ginseng Varieties

    Ginseng Varieties

    This valued plant known as ginseng can be purchased in different forms. White ginseng is what the root is called before any processing occurs. White is the natural color of the root after it is harvested and washed. When dried, the root becomes a light brown color. When the ginseng root is processed using steam and heat, it becomes red. This procedure is done in order to preserve the plant and its constituents. The heat process is thought to help stimulate the active properties in ginseng and some herbalists believe that the red ginseng is more stimulating than the white.2 There are a variety of types as well as grades of ginseng and ginseng products.

    This is due in part to Differences in age, source, part of the root used and the preparation. The old wild plants are the most desirable because of their nutritional content which is believed to increase with age. The western world often treats the different ginseng varieties the same. But in traditional Chinese medicine, the various types are thought to possess distinct properties. They are each valued for their Differences and used for divergent purposes.

    The Asian variety of ginseng (Panax ginseng) grows principally in Korea, Japan and China. Centuries ago the ginseng plant grew wild and was abundant. But because of the claims of its healthy properties, it has been depleted in its natural state almost to the point of extinction. Now it is grown commercially for export and local medicinal use. The Asian ginseng is often exported to the western world. It is unfortunate but most of the ginseng grown now is cultivated using pesticides to promote mass production. The Asian plant has similar composition to the American variety with some variations. It contains ginsenosides, the active ingredients, between one and three percent. There are at least thirteen of these different triterpenoid saponins, referred to as ginsenosides. The Asian contains Rb1, Rb2, Rc, Re, and Rg1.3

    The Wild American variety of ginseng is still found in its natural state. This variety grows naturally and organically but is hard to find. There is an increasing amount of American ginseng being cultivated and grown for commercial use. Fertilizers and pesticides along with modern farming equipment aid in the production and high yield of this variety of ginseng. The American ginseng is thought to be less stimulating than the Asian variety. The American ginseng contains primarily the ginsenosides Rb1 and Re and does not contain Rb2, Rf and sometimes not Rg1.4 Generally, the American ginseng is thought to possess more of a sedative effect than the Asian ginseng. Differences in the chemical structures of the ginseng roots makes the identification process between the varieties easier. Siberian ginseng, though not considered a “true ginseng,” contains similar properties to the other varieties.

    It was discovered in Siberia but is now cultivated around the world. Some of the saponins found in this variety are not the same as the Asian and American. But is known to have the same tonic and stimulant effect as the “true ginseng.”5 It is believed to be less potent than either the American or Asian ginsengs. Research has documented may of its valuable adaptogenic capabilities.

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    STOMACH CANCER, GEOGRAPHY AND GARLIC
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    Date: June 25, 2005 10:17 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: STOMACH CANCER, GEOGRAPHY AND GARLIC

    STOMACH CANCER, GEOGRAPHY AND GARLIC

    Less than five years ago, the New York Times reported:

    “Large Differences in cancer rates were seen between regions of high and low consumption of these allium vegetables. Those living in high-consumption areas had less than half the risk of developing stomach cancer as people who lived where little or no garlic-type foods are eaten. And while fre quent consumption of other fresh vegetables and fruits was also linked to a reduced cancer risk, garlic seemed to multi ply the benefit, providing even more protection than would be expected from simply adding on its separate benefits.”42 No one totally understands garlic’s anti-cancer properties. One possible explanation is that garlic has the ability to block nitrosamines which are considered powerful carcinogens in the digestive tract. Clinical studies have suggested that garlic extract is more effective than vitamin C in blocking nitrosamine formation not only in the laboratory, but in humans as well. Research has clearly shown that garlic can guard living tissue against carcinogens that cause cancer of the breast, esophagus, stomach, colon and rectum.

    The fact that garlic inhibits tumor growth, blocks the action of cancer- causing substances, and boosts the immune system makes it a valuable cancer preventative.

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    CLA and Cows
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    Date: June 22, 2005 09:52 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CLA and Cows

    CLA and Cows

    Nutritional developments like that of CLA couldn’t come at a better time. America is a nation obsessed with weight, but successes in battling weight seem harder and harder to come by. Is there a nutritional reason for this? Have we been barking up the wrong tree in recent years, starving ourselves for fear of gluttony rather than looking at broader nutritional reasons for fat accumulation? For example, Dr. Cook says that modern nutritional dogma is that fat is bad. “I’m not sure the dogma’s right. We need to get down to very specific fatty acids.”51 One of the most exciting developments coming from CLA research is that modern animal-raising techniques may be partially responsible for those of us who eat meat getting fat around the middle, even though our consumption of meat may have declined or, at least, stayed about the same in recent years.

    CLA has been declining in our diet. This one nutrient’s lack may mean many of us are gaining fat, despite eating less overall fat.52

    This desire to simply eliminate fats without looking at the broader nutritional picture has its roots deep in our culture. The desire to starve ourselves to lose weight goes back centuries. We have often thought weight gain came solely from lacking self-control when, often, nothing could be further from the truth.

    Take for example the experiences of conscientious objectors during World War II. These men who chose, for religious reasons, not to fight in the war, contributed in other ways. One group at the University of Minnesota underwent forced starvation to help scientists learn ways to help concentration camp victims recover after liberation.

    Science learned many useful things, but one thing stands out. The objectors grew more hungry as they recovered and ended up weighing five percent more after they recovered than before the experiment began. (The same can be said for refugees and concentration camp victims, who also weighed more, on average after their ordeals than before.)53 This idea of dieting being the full answer to weight loss still persists, often tragically. Many have died of anorexia, obsessed with self-image. Others have died directly from ill-conceived meal replacement programs.54 In the 1980s, Americans spent $15 billion on diet soft drinks alone,55 but consumers weighed more on average when the decade was over than when it began. You’d think all of this energy and dieting spent on the effort would have helped people lose weight. (Thankfully, many people have succeeded in losing weight and keeping it off. According to Dr. Pariza, this may well be the most significant part of CLA, not so much in losing the weight, but in helping people keep it off.56)

    To drive the point home further, consider your parents. They ate a diet that was likely higher in fat than yours. They never saw “lite” versions of snacks in the store. Yet they, in general, weighed less than we do. Why? Surely exercise may have had something to do with it, but, no one has the complete answer. It seems likely that nutrition too played a role. CLA itself may hold part of the reason. As we have seen, CLA nutrition means less fat and more protein in our bodies. Recent research is showing that the amount of CLA in cows has dropped substantially since the times of our parents. In 1963, scientists found that CLA was as much as 2.81 percent of milkfat. The amount of CLA in the milk products varied with the seasons. At some times during the year, cows ate grass. At other times, they ate feed. However, in 1992, Pariza and his colleagues did a large food survey and found that this variation in CLA is no longer occurring. Furthermore, the amount of CLA in dairy products rarely gets above 1 percent of the milkfat. 57

    In another research paper in 1994, scientists noticed that Australian cows have as much as three or four time the amount of CLA in the meat from similar American animals. Why? These Differences probably “reflect different feeding conditions.” 58

    Today, farmers use more efficient feeding methods that rely less heavily on natural grasses. This means less CLA in the meat we eat, and less CLA can mean a higher percentage of fat on our bodies. Consider too that skim milk contains virtually no CLA with its no fat content. This lack of CLA may actually hinder some people’s efforts to lose weight.

    The lesson here seems to be that gluttony guilt would be better focused on balanced living. Healthy lifestyles coupled with the right supplementation can make a difference. CLA, though no magic bullet, adds to this lifestyle and could be the key that finally opens many weight (and fat) management doors. It could help many people keep the weight off.

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    An Essential Fatty Acid
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    Date: June 22, 2005 09:42 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: An Essential Fatty Acid

    An Essential Fatty Acid

    When most people think of fat, they think of the white gooey stuff that deposits around the waist or around the thighs. In many ways, it can be tempting to spell it “fatt”—making it an unspeakable, four-letter word. But at the level of the cell, at the level of molecules, fat means something more complicated. First of all, fat is one method the body uses to store energy for long periods. When we eat, we must either immediately burn the fuel as energy, or store it as fat or as protein for muscle. Fat, therefore, is one way our body tries to make something useful from food. Furthermore, fat serves a vital function in each cell. The membranes of our cells are all made of fat—a collection of fatty acids really. Every cellular function must pass through this barrier.

    Hormones act on fat, energy passes through fat, life proceeds because of fat. Fat, then, is not a dirty word. It is vital. Scientists have identified more than 100 fatty acids, and many more fatty acids could theoretically exist. 4 The body produces all the fatty acids it needs except three—linoleic acid, arachadonic acid and linolinic acid. Much the way certain vitamins like vitamin C are essential to good health and are not produced naturally, these acids are essential, hence their name—essential fatty acids. The body can produce linolinic acid and arachadonic acid from linoleic acid, so in some senses, the only vital fatty acid is linoleic acid.

    Linoleic acid sits like a highway of some 58 atoms of carbon, oxygen and hydrogen.5 The carbon is the center line with the hydrogen and oxygen being the cars traveling along the way. (Thousands of chemicals contain these three elements in nature. It is the order of these cars, and the varied shapes of the highway, that lead to many different kinds of chemicals.) The highway of linoleic acid sits curved like a mountain switchback. Conjugated linoleic acid is basically a straighter version of linoleic acid. Scientists have studied CLA at least since the 1930s.6 These studies show that bacteria in the stomach convert linoleic acid into CLA.7

    CLA occurs naturally in many foods including some vegetable oils, which are the best sources for linoleic acid, but the best source of CLA is in beef, veal and certain dairy products.8 Dr. Mark Cook, who began working with Pariza around1990, said the reason that sheep and cows and other similar animals provide higher sources of CLA is because these animals are ruminants—they have multiple stomachs for bacteria to convert linoleic acid in, instead of one, as in humans.9 The chemistry of CLA really isn’t that significant to any but a researcher, but, in essence, a double bond of two of the carbon atoms switches position from its position in linoleic acid.10 Instead of having two atoms between a pair of double chemical bonds, as in linoleic acid, there is only one atom in between. This is why chemists named it conjugated linoleic acid. This chemical chain can exist in several forms with the double bonds at positions 9 and 11, positions 11 and 13 or at positions 10 and 12.11 Hence, there are several forms of CLA. Which ones are most effective in providing nutrition, or if they are equally effective, is still a question somewhat unresolved, although it is unlikely that it is the 11,13 version.12 What has been resolved is that CLA is one of the most important, and most exciting nutrients isolated in recent years. And there’s good reason to look at supplementing it into your diet. Why? Because we may not be getting as much of it as we once did, particularly in the United States.13 Cows and other animals have traditionally eaten fresh grasses as a way of getting nutrition, but agricultural development makes it more efficient and cost-effective to provide cattle feed grains and other means of nutrition, instead of natural grasses. That seems to mean that the cows today provide much less CLA in their beef than those of only a generation ago. One study out of Australia showed that cattle in that South Pacific nation had more than twice the amount of CLA than American cows. The reason may well be Differences in feeding patterns. As evidence for this, have you ever wondered why it is that Americans, despite eating less fat and meat than a generation ago, end up being more fat than their predecessors? Indeed, America’s obesity rate is up substantially over the last 15 years.14

    Declining amounts of CLA may explain this disturbing trend. But more on that later.

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    Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplement
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    Date: June 21, 2005 05:10 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplement

    Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplements

    By Adina Licht, MS

    Adina Licht, M.S. is a Nutritional Scientist and Science Writer who works as a Marketing Specialist for Source Naturals. She has a B.A. in Environmental Science from UC Berkeley, an M.S. in Nutrition and Food Science from San Jose State University, and training in Technical Communication from Cal State Hayward. Her work has appeared in publications such as Advances in Packaging and Development, Health Supplement Retailer and Delicious Living.

    Americans Need More Nutrients

    The U. S. population is drastically malnourished. According to the latest A. C. Nielsen survey, only 12% of Americans claim to eat the 5 recommended servings of fruits and vegetables each day (Warner, 2004). And approximately 1/3 of the calories that people do consume are from nutrient-poor foods such as alcohol and soda (Yang, 2004). This combination has led to a population that consumes too few nutrients, which according to an article in the Journal of the American Medical Association (Fletcher, 2002) puts people at risk for long-term health concerns. With Americans eating fewer healthy foods, taking a daily multiple is one way for people to increase their intake of nutrients. But the search for what defines a good multiple can be confusing, even to health care professionals.

    The Confusing U.S. Government Standards

    Scientists first recognized the need for vitamins in the early 1900s (Levenstein, 1993). But setting U. S. government standards for vitamins and minerals didn't start until healthy soldiers were needed to fight World War II. And when a committee of scientists was asked to determine the levels of nutrients needed to maintain good health they could only agree on "recommended allowances" to prevent deficiency with a wide margin of safety. In 1941, these allowances became the first Recommended Dietary Allowances (RDAs) for the nation (Levenstein, 1993). In 1997, the Food and Drug Administration (FDA) used latest RDAs to set the new Dietary Reference Intake (DRI) standards, which included Adequate Intakes (AIs) for when there was insufficient evidence to determine an RDA, and Upper Intake Levels (ULs) as the safe daily upper limit. To simplify the information, food labels express nutrient information as a percentage of the Daily Value (DV), which includes RDA values for a healthy adult who consumes 2000 calories per day (Whitney, 2002). However, these values do not include AIs or ULs and many individuals need different levels of nutrients than these.

    Confusing Standards equals Confusing Recommendations

    The RDAs and subsequent DRIs are the basis of the nutrient standards for at least 40 different nations and many professional health organizations. Currently, the American Dietetic Association (ADA) recommends that people who cannot reach the DRIs through diet take a multiple with nutrient levels that do not exceed the RDAs (JADA, 2001). And in 2002, the American Medical Association (AMA) published a paper that included a recommendation for all adults to take RDA levels of vitamin supplements in their Journal of the American Medical Association (Fletcher, 2002). Despite the benefits of having guidelines, most people only hear about the RDAs and DVs, which may be too low for preventing deficiencies while the ULs and AIs, which can be much more beneficial are rarely discussed. For example, the Daily Value of Vitamin E to prevent deficiency is 30 IU while the daily Upper Intake Limit is 1,467 IU. But, according to the ADA, as many as 75% of cardiologists recommend vitamin E to their patients to promote heart health, usually at a dosage of 400 IU (ADA, 2001; Meydani, 2004; & Whitney, 1998). And the Daily Value for Vitamin C is 60 mg while the daily Upper Intake Limit is 2000 mg, but in clinical studies it took 500 mg per day to help maintain healthy blood pressure (Whitney, 1998, & Hendler, 2001).

    Alternative Recommendations

    Lyle MacWilliam is a biochemist and former health advisor to the Canadian Ministry of Health, who decided to research, analyze and publish the Comparative Guide to Nutritional Supplements. In this book, the individually published recommendations from seven nutrition experts (Phyllis Balch, CNC, Dr. Michael Colgan, Ph.D., Dr. Earl Mindell, Ph.D., Dr. Michael Murray, N.D., Dr. Richard Passwater, Ph.D., Dr. Ray Strand, M.D., and Dr. Julian Whitaker, M.D.) were combined to create an ultimate blended standard of recommended median intakes for 39 nutrients to promote health. Those nutrients include vitamins, minerals, phytonutrients, and other supplements, that span 14 different health categories and are much closer to the Upper Intake Limit government standards. The guide also includes information about recommended forms, safety, purity and quality (MacWilliam, 2003). One of the most profound Differences between MacWilliam?s compiled recommendations and the DRIs is the difference in the number of supplements: 39 vs. 26 respectively. The Comparative Guide standard includes additional nutrients, including many more antioxidants, based on decades of clinical research about their benefits. For example, the fat-soluble antioxidant Coenzyme Q10 that your body manufactures less of as you age is included. So is the fat and water-soluble antioxidant alpha lipoic acid that helps recycle other antioxidants such as vitamins C and E (Hendler, 2001).

    Top Ranked Multiples for Optimal Health

    In the latter half of MacWilliam's book he uses this ultimate blended standard to rank and compare 500 manufactured multiples. Of the five top-ranked multiples, only the Source Naturals multiples, Life Force and Élan Vitàl, are widely available at natural product stores and health outlets. And the new and improved Life Force formulation now rates higher than any of the products evaluated in the current edition of this guide (MacWilliam, 2004; & Mac-William, 2003). The ingredients that can be found in today's multiple supplements can vary greatly. But multiple choices don't have to lead to confusion. Health professionals, such as Lyle MacWilliam, understand the importance of remaining curious, evaluating the available research, and conferring with other scientists to determine the nutrients that support optimal health.

    References

    American Dietetic Association. 2001. Vitamin E: Disease Prevention for your Good Health. American Dietetic Association Website. Available at: Public/Other/index_nfs1001.cfm Fletcher, R. H., & Fairfield, K. M. 2002. Vitamins for Chronic Disease Prevention in Adults. JAMA. (23)287:3116-3129. Hendler, S. S., et al. 2001. PDR for Nutritional Supplements. Thomson Healthcare: Montvale. Pages 11-12, 17-21, 60-62, 103, 416-421, 486-498. JADA (Journal of the American Dietetic Association) 2001. Vitamin and mineral supplementation. J AM Diet Assoc.101: 115 Available at: Public/NutritionInformation/92_8343.cfm Levenstein, H. 1993. Paradox of Plenty: A Social History of Eating in Modern America. Oxford University Press: New York. Pages 13-15, 64-67. MacWilliam, L, et al. 2003. Comparative Guide to Nutritional Supplements. Northern Dimensions Publishing: Vernon. Pages 62-70. MacWilliam, L. 2004. Comparative Guide Individual Assessment of New Life Force Formulation. Warner, J. 2004. Few Follow '5 a Day' Fruit and Vegetable Rule. WebMD website. Available at: ent/Article/93/102158.htm Whitney, N. W., & Rolfes, S. R. (1998). Understanding Normal and Clinical Nutrition, 5th ed. Page 358. Whitney, E. N., & Rolfes, S. R. 2002. Understanding Nutrition. 9th ed. Wadsworth Thomson Learning: Belmont. Pages A, B, Y, 13-20, 55-56, 307, 331, 335-341, 401. Yang, S. 2004. Nearly one-third of the calories in the US diet come from junk food, researcher finds.



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    Mushroom Miracales
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    Date: June 18, 2005 09:11 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Mushroom Miracales

    Mushroom Miracles by Bert Hoffman Energy Times, April 12, 2004

    Mention mushrooms and few people immediately recognize these humble fungi as important tools that can be used to boost well-being. More often, folks identify mushrooms as food with a peculiar appeal. But mushrooms' potential impact on health far surpasses their culinary reputation.

    You don't have to stretch your imagination too far to understand why mushrooms have been much neglected in the modern, Western medical search for plants that can boost health.

    Unable to make chlorophyll, often dependent on the kindness of other nutrient-producing organisms for their survival, these humble fungal denizens of dark, damp spaces seem to prefer an anonymous existence that is out of sight and out of the consciousness of the scientific mind.

    However, mushrooms have now assumed a spot in the center of the research spotlight. Because of their potent content of natural chemicals that appear to have a strong influence on human health and well-being, during the past decade mushrooms have been the subjects of intensive studies on how they can be used to reduce the risk of cancer and to treat these diseases.

    Appropriately, this recent round of research began in a place that has long revered these diminutive organisms: Japan. Japan and other Oriental countries have traditionally recognized the immense value of mushrooms as both food and medicine.

    Food and Medicine

    As an ancient Chinese saying notes, "food and medicine share a common origin." And one of the very earliest Chinese medical books, Shen Noug's Herbal (Shen Noug Pen Ts'ao Jing), first noted the extraordinary beneficial effects of eating mushrooms 2,000 years ago, back in the first century.

    More recently, but still well ahead of Western medical experts, in 1575, Pen Ts'ao Kang Mu (a Chinese compendium of medicinal therapies), written by Li Shi Zhen, outlined the medical benefits of about 20 mushrooms.

    Nowadays, modern researchers believe mushrooms' usefulness stems from the fact they contain a wealth of antioxidants. But these aren't just any antioxidants. Scientists think that some of these chemicals can potentially drop your risk of cancer, significantly lower blood pressure, help the body fight diabetes, offer protection for the liver, alleviate some of the ill effects of inflammation, lessen the chance of blood clots and help the body's immune system fend off viruses and other microbes. Quite a collection of benefits for these lowly beings!

    The 10,000-Year Mushroom

    Through the ages, the reishi mushroom (also known variously as the Mannetake, or 10,000-year mushroom, and the Immortality Mushroom) has been the most popular mushroom in Chinese, Korean and Japanese cultures. The reishi mushroom is frequently depicted in a wide variety of traditional Oriental artwork and even puts in an appearance in Chinese royal tapestries.

    To some, reishi's power goes beyond the natural and include the supernatural. Originally grown on aging plum trees, reishi is also sufficiently well regarded to be employed by the Japanese as a good luck charm. But you don't have to believe in the supernatural to be superbly impressed with reishi. The beneficial natural substances in reishi include steroids, lactones, alkaloids, triterpenes and polysaccharides.

    Large Molecules

    Of these chemicals, polysaccharides (complex chains of sugars) in particular have intrigued researchers looking into the way mushrooms help health. These polysaccharide macromolecules are very large (for molecules) and complex, a complexity that leads researchers to believe they are capable of conveying a huge amount of biological information that help the immune system stop cancer in its early stages. The Differences in the benefits of various polysaccharides stems from their intriguing geometrical shapes.

    Distinctive Differences

    Even though two distinctive polysaccharides may contain the same number of carbon, hydrogen and oxygen atoms, their three-dimensional Differences-the way they are structured and branch off in different directions-can endow them with very different health benefits.

    Though they all share a basic structure (usually, these molecules consist of a main chain of atoms with various side chains), the slight variations of the side chains changes their effects.

    By deciphering the microscopic structures of these molecules, scientists think they are beginning to uncover which ones are most effective against cancer. For instance, in isolating a particularly useful polysaccharide called beta-D-glucan from reishi, researchers have found that this substance fights tumors in lab experiments (Chem Pharm Bull 1981; 29: 3611).

    Maitake Benefits

    Meanwhile, beta-D-glucan and other extracts taken from the maitake mushroom have also been shown to possess powerful anti-cancer effects in lab experiments (Immunopharm Immunotox; 19:175).

    In one instance, researchers in the laboratory who were trying out various substances on prostate cancer cells found that applying extracts of maitake results in a kind of programmed self-destruction (apoptosis) of these undesirable cancer cells (Molec Urol; 4:7). In addition, another substance known as maitake d-fraction has been shown to strongly fight cancer in lab animals-in one study, their liver cancer growths were reduced by up to 90% (Ann NY Acad of Sci; 833:204).

    At the same time, research in China on people has demonstrated that maitake may help reduce tumors and alleviate the effects of leukemia (Alter Comp Ther 12/98; 420).

    According to A.S. Daba and O.U. Ezeronye (Afr Jrnl Bio 12/03; 672), "Mushroom polysaccharides offer a lot of hope for cancer patients and sufferers of many devastating diseases.

    " [These substances support]...a fundamental principle in Oriental medicine...[they help] regulate homeostasis of the whole body and... bring the diseased person [back] to his or her normal state."

    The Activity of Active Hexose Correlated Compound Active Hexose Correlated Compound (AHCC), an extract taken from shiitake and other mushrooms, is a relatively new substance that is also being researched for its anti-cancer benefits.

    Studies on AHCC began in Japan in the 1990s when scientists looked at how it could potentially help people recovering from liver cancer. In those tests, researchers found that giving people AHCC apparently helped them survive longer.

    In the future, scientists feel certain that they will uncover even more anticancer uses for mushrooms and the chemicals they contain. A key advantage to these natural substances is their lack of side effects. For instance, in research on an anti-cancer chemical called lentinan, taken from shiitakes, investigators have found that less than one percent of people experience the kind of discomfort that make them discontinue treatment. (This chemical has been used to treat stomach cancer.)

    But a long list of beneficial mushroom substances are probably still waiting to be discovered. More evidence of mushrooms' benefits: A study of mushroom workers in a part of Japan called the Nagano Prefecture found that these farmers enjoyed a significantly lower cancer rate than other inhabitants of that part of the country.

    In the rest of Japan, about one in six hundred people dies of cancer. But that rate death rate drops to about one in a thousand for mushroom raisers who eat a diet heavy in mushrooms.

    John Smith, PhD, from the University of Strath-Clyde, notes that "...increasing evidence [shows] mushrooms offer a remarkable array of medicinally important compounds that have yet to be evaluated by Western medical scientists." Mushrooms offer the best of both worlds: good health that tastes great.



    --
    Vitanet ®

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    Truth in Labeling
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    Date: June 14, 2005 10:44 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Truth in Labeling

    Truth in Labeling by Diane Stanton Energy Times, June 14, 2004

    Do you or don't you read food labels when you shop? If you don't, you're missing out on a prime source of information about your meals. If you want control of your health, focus on package labels and pick your foods carefully.

    The large print on food labels focus on what are called macronutrients: carbohydrates, fat and protein. Some of the smaller categories convey information about vitamins, fiber, and minerals, as well as the totals of fat and saturated fat contained in food. So, you have no excuse for claiming ignorance about your diet: the truth is in the labels.

    Food labels can be confusing to the uninitiated. Go into a big food store and you can be faced with what seems to be a forest of food information: more than 15,000 labels. Add to that fact that every year more than 30,000 new food products can be introduced to the marketplace, and what you're faced with is a jungle of food labels.

    That overwhelming wealth of food label information doesn't mean you should throw up your hands in dismay and give up reading and deciphering labels. You should arm yourself against that sea of labels with knowledge and, by understanding them, end your confusion and build your health.

    Label History

    A hundred years or so ago, food labels were only required to list the name of the food contained inside the package. The contents, quality and processes used to make the food were often a mystery. Little or no disclosure to consumers was made about how their food was created.

    By the early 1920s, the federal government, via the Food and Drug Administration (FDA), began requiring food companies to list the net weight of food on labels as well as the names and addresses of food processors and distributors. Finally, by the 1970s, listing basic nutritional information was mandated in a uniform way so that shoppers could have some basis for comparing foods. Then, in 1990, the Nutrition Labeling and Education Act made major alterations to the kinds of labels that had to be included on food packages.

    The FDA and the US Department of Agriculture (USDA) required significant changes to food labels that were supposed to make it easier for consumers to eat healthier diets. The labels requirements of 1994 included five major changes:

  • • The nutrition information on the label had to be printed in larger, more legible type.
  • • This condensed information had to be on the back or side of food packaging and titled as "Nutrition Facts." This type of information is also shown in grocery stores near the fresh food displays of fish, fruits and vegetables.
  • • The label had to include a column of information tagged as the "% Daily Value," designed to help consumers understand how the food could fit into a healthy diet.
  • • Each label had to include information about fat, cholesterol, fiber, sugar, calories from fat, and other information relevant to designing a healthy diet.
  • • The computed serving sizes were supposed to be more realistic and reflect the amount of food people actually eat at one sitting.

    Label Questions

    Consumer questions regarding food labels have led researchers to look into ways to help shoppers comprehend what food labels tell them. These studies are designed to help consumers match up their nutrition requirements with the foods they buy.

    For instance, at the University of Illinois at Urbana-Champaign, scientists have devised a label tool called See It, Do It, Teach It to help people improve their diets through comprehension of food label information. " One of the goals of the project was to help...teenaged girls and menopausal women understand how they can get the daily requirement for calcium into their diet in order to help prevent osteoporosis," says Karen Chapman-Novakofski, PhD, associate professor and nutritionist in the school's College of Agricultural, Consumer and Environmental Sciences.

    According to the See It, Do It, Teach It program, you should think of food labels as consisting of two sections:

  • • Food items you should limit: total fat, saturated fat, cholesterol, sodium and, if you're eating a low-carb diet, total carbohydrates
  • • What you may need to increase: vitamin A, vitamin C, calcium and iron

    " Much more attention has been paid to what people should limit rather than the nutrients needed. The average consumer doesn't know, for instance, how much vitamin A 10% of the Daily Value is, or how much calcium 25% of the Daily Value is," Dr. Chapman-Novakofski says.

    Upping Calcium Intake

    In their eight-week study of people's calcium consumption (Journal of Nutrition Education and Behavior 4/04), the University of Illinois research team found that people didn't know how much calcium was in the food they ate.

    After the initial part of the study, in which participants were shown how to look for calcium on labels, "the post-test revealed that the participants significantly increased their calcium intake to 821 mg per day, up from 372 mg per day," notes Dr. Chapman-Novakofski.

    " That's a lot closer to the daily requirements of 1,200 mg per day for men and women over 50, 1,000 mg for men and women aged 19 through 50 and 1,300 mg per day for [youths aged] 9 to [18] years," she adds.

    Parts of the Label

    The first item at the top of a nutrition food label tells you the portion size that the label measures. An important point to remember: these sizes are determined individually by each manufacturer. Consequently, all of the other values on the label are measured per portion.

    So, if you are comparing foods made by two different companies that employ very different portion sizes in their nutritional calculations, your label comparisons may be complicated.

    Another fact to be aware of: the listed portion size may be an odd division of the food within the container and not reflect a common-sense division. For instance, some food packages are labeled as containing 2.5 portions.

    And, to make things even more interesting, small boxes of candy that you might think contain barely enough for one helping may be labeled by the manufacturer as having two or more portions. As a result, if you eat the whole box, you often have to at least double the number of indicated calories, etc. to figure out the nutrients and calories you are consuming.

    The section of the label that notes calories, calories from fat and percent daily values is listed under the portion size. Here you are told how many calories you consume when you devour one portion and how many of those calories are derived from fat.

    This label focus on fat originated when consumers and dietitians were very concerned about Americans' fat consumption and hadn't yet switched their focus to carbohydrate consumption as a prevalent dietary health priority.

    Also included on the label: the daily value percentages aimed at showing you how much out of a total day's intake of various nutrients a portion bestows upon you.

    These percentage numbers are based on a theoretical analysis of a diet that contains 2,000 or 2,500 calories a day. (A notation at the bottom of the label tells you whether the calculation is based on 2,000 or 2,500.)

    Carb Facts

    If you've been eating a low-carb diet (or are planning this type of diet), the section of the label that lists carbohydrates may be especially useful. Under this heading, the label lists the totals for fiber and sugar.

    No matter what diet you are on, dietary fiber is desirable, since it represents indigestible carbohydrates that both pass through you without conveying any calories and keep beneficial bacteria in your digestive tract healthy.

    Most people want to limit their sugar totals, however, since this nutrient may raise your risk of being overweight and, when you eat a lot of it, may contribute to immune problems.

    Interestingly enough, when food chemists compute what is in food, they perform lab tests known as assays to distinguish its ingredients. (The manner in which these tests are performed are very strictly regulated by the FDA.)

    In fact, just about every nutrient listed on a food label is determined by laboratory test except for the carbohydrate content: the amount of water, fat, crude protein and ash are determined this way. But the total carbs are computed by simply subtracting the total of the other ingredients from the total amount of food, a kind of process of elimination.

    So while fat and protein are measured with precise lab tests, carbohydrate totals are figured by the leftovers. (The water and ash, by the way, are not usually listed on food labels.)

    Within the general carbohydrate group, are several categories of carbohydrates that produce very different effects in your body. These categories can be divided into sugar, sugar alcohols, dietary fiber and a collection of various chemicals that include organic acids, flavonoids, gums, lignans and others.

    According to the FDA, the food label only has to list the total carbs, sugar and dietary fiber. But some food companies now list things like sugar alcohols.

    Blood Sugar Effects

    Not all of these types of carbohydrates behave the same way in your body. For example, when your body digests table sugar, it turns immediately into blood sugar. So sugar and most other carbohydrate is what we call "digestible carbohydrate." Other carbs, such as sugar alcohol or glycerine, can be digested but do not turn to blood sugar. Still others, such as dietary fiber, are indigestible and pass through your body without impacting your blood sugar level.

    To date, the FDA has not focused on these important biochemical Differences and treats all carbohydrates alike. This means that when you look at a food label, you do not see a number for the carbs that impact your blood sugar level. To do so, simply subtract the number of grams of fiber from the total number of carbohydrate grams.

    Net Carbs

    Recently, the phrases "low carb," "net carb" and "impact carbs" have begun to appear on food labels. These are not defined by the FDA; they were put on labels by by companies to help consumers pick out foods that are acceptable on low-carb diets. To arrive at the total of net carbs, food companies subtract the total amount of fiber and sugar alcohol from the total carbohydrates.

    Fiber Calculations

    Since the body cannot digest fiber, this nutrient (which is still important for good health) is not calculated into the total amount of carbohydrates. As for sugar alcohols, while-technically speaking-these are carbs and they do have calories, they have little effect on blood sugar and usually are not counted in total carbohydrates.

    According to the American Dietetic Association, people with diabetes who are managing their blood sugars using the carbohydrate counting method should "count half of the grams of sugar alcohol as carbohydrates since half of the sugar alcohol on average is digested.

    " Fiber is not digested, however. If the serving of food has more then 5 grams of fiber one should subtract the grams of fiber from the total carbohydrate grams." As you can see, when it comes to food, as in most things, knowledge is power. If you want power over your health, you need power over the food you eat. The road to that power is by reading food labels. What's in the food you're eating every day may surprise you.



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    Vitanet ®

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    Recognizing the Signs: Roadmap to a Healthy Heart
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    Date: June 13, 2005 10:06 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Recognizing the Signs: Roadmap to a Healthy Heart

    Recognizing the Signs: Roadmap to a Healthy Heart by Louis McKinley Energy Times, January 2, 2004

    From time immemorial, people have tuned into life's lessons that come from the heart. Sadly, times are changing: If you're like most inhabitants of today's harried world, you may be too distracted to detect important clues about your cardiovascular circumstances.

    And while heart lessons may be more complicated than simply connecting the physiological dots, understanding those heart messages are imperative for improving and maintaining your heart health.

    Every cell in your body relies on heart-powered blood flow to keep it supplied with nutrients, oxygen, hormones and other natural chemicals necessary for survival. Without that supply of life-giving substances, few cells in the body-including those within the heart itself-can survive very long.

    And just as damage to a major roadway can cause mayhem with traffic patterns, damage to blood vessels and the heart can wreak a lumpy cardiovascular havoc that blocks the passage of blood and endangers your heart's well-being.

    Your Heart Disease Chances

    Within the last ten years, scientific research performed by investigators around the world has focused on the specific factors that most strongly influence your chances of developing heart disease and suffering either a heart attack or a stroke.

    While much of your risk depends on your genetic inheritance and family history, several factors that determine your heart health are within your control.

    The most important factors you can do something about include:

    * Smoking: free radicals generated by burning tobacco causes significant damage to blood vessels and other cells

    * Lack of exercise: the human body is designed for consistent, moderate physical activity; without exercise, the body slacks off in creating antioxidant protection for arteries

    * Diabetes: when excess blood sugar persists, physiological processes begin that endanger the heart and arteries

    * Cholesterol: when oxidized (a chemical process that has been compared to a kind of internal rusting), cholesterol can form artery-blocking plaque; antioxidant nutrients like vitamin C and natural vitamin E may help the body limit this process

    * High blood pressure: excessive pressure within the blood vessels raises the risk of damage to the heart and arteries; a program of weight loss and exercise can help control blood pressure

    * Being overweight: the extra body fat carried around your middle is linked to a greater risk of heart problems

    Heart Attack Signs

    Do you think you know what a heart attack feels like? Well, if you think it feels like a dramatic pain somewhere in your chest that knocks you to the floor, you're probably wrong. "Most heart attacks do not look at all like what one of my colleagues calls the 'Hollywood' attack-the heart attack you see on television or in the movies," warns Julie Zerwic, MD, professor of surgical nursing who has studied what happens when people develop heart disease and suffer damage to their hearts.

    "The symptoms [of heart problems] are not necessarily dramatic. People don't fall down on the floor. They don't always experience a knife-like, very sharp pain. In fact, many people describe the sensation as heaviness and tightness in the chest rather than pain," she says. And, if you're a woman experiencing a heart attack, you may not even feel discomfort specifically in your chest. Instead you may experience a severe shortness of breath. The apparent ambiguity of the discomforts caused by a heart attack lead many people to either ignore them or take hours to realize they need to go to the emergency room at the hospital.

    Consequently, much fewer than half of all individuals undergoing a heart attack actually go to a hospital within an hour of the start of the attack. That delay can be a fatal mistake.

    "Timing is absolutely critical," laments Dr. Zerwic. "If treatment starts within a hour after the onset of symptoms, drugs that reestablish blood flow through the blocked coronary artery can reduce mortality by as much as 50%. That number drops to 23% if treatment begins three hours later. The goal is to introduce therapy within two hours."

    However, in Dr. Zerwic's research, only 35% of non-Hispanic whites go to the hospital within an hour of the start of a heart attack. And among African-Americans, the number of people going to the hospital right away drops to a frighteningly low 13%.

    Often, people will lie down or use a heating pad to relieve the tightness they feel in the chest," says Dr. Zerwic. "They may take some medicine and wait to see if that works. All these steps postpone needed treatment."

    Signs of a possible heart attack include:

    * Chest discomfort: Heart attacks most frequently cause discomfort in the center of the chest that can either go away after a couple of minutes (and come back) or persist. The discomfort may feel like strong pressure, fullness or pain.

    * Upper body discomfort: An attack may set off pain or discomfort in either or both arms, and/or the back, neck, jaw or stomach.

    * Shortness of breath: Chest discomfort is frequently accompanied by shortness of breath. But it's important to note that shortness of breath can take place even in the absence of chest discomfort.

    * Other signs: You can also break out in a cold sweat, or feel nauseated or light-headed.

    A Woman's Sleep Signs

    If you are a woman who suddenly experiences a marked increase in insomnia and puzzling, intense fatigue, you may be in danger of an imminent heart attack.

    In an attempt to understand how women's symptoms of heart problems differ from those of men, researchers talked to more than 500 women in Arkansas, North Carolina and Ohio who had suffered heart attacks. (Technically, what they had experienced is referred to as acute myocardial infarction.)

    They found that chest pain prior to a heart attack was only reported by about 30% of the women surveyed.

    More common were unusual fatigue, sleep disturbances and shortness of breath (Circulation Rapid Access, 11/3/01).

    "Since women reported experiencing early warning signs more than a month prior to the heart attack, this [fatigue and sleep problems] could allow time to treat these symptoms and to possibly delay or prevent the heart attack," says researcher Jean C. McSweeney, PhD, RN, nursing professor at the University of Arkansas for Medical Sciences in Little Rock. In Dr. McSweeney's study, more than nine out of ten women who had heart attacks reported that they had had new, disturbing physical problems more than a month before they had infarctions.

    Almost three in four suffered from unusual fatigue, about half had sleep disturbances, while two in five found themselves short of breath.

    Other common signs included indigestion and anxiety.

    "Women need to be educated that the appearance of new symptoms may be associated with heart disease and that they need to seek medical care to determine the cause of the symptoms, especially if they have known cardiovascular risks such as smoking, high blood pressure, high cholesterol, diabetes, overweight or a family history of heart diseases," says Dr. McSweeney.

    Dr. McSweeney warns that, until now, little has been known about signs that women are having heart trouble or heart attacks. The fact that most of Western medicine's past attention has been on heart problems in men has obscured the warning signs in women. As part of Dr. McSweeney's studies, she and her fellow researchers have discovered that more than 40% of all women who suffer a heart attack never feel any chest discomfort before or during the attack.

    "Lack of significant chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments," she notes. "Many clinicians still consider chest pain as the primary symptom of a heart attack."

    Vitamins for Diabetes and Heart Disease

    Having diabetes significantly raises your chance of heart disease, which means that keeping your blood sugar levels under control can reduce your chances of suffering a heart attack.

    Today, 17 million Americans have diabetes and, as the country's population in general gains weight and fails to exercise, the number of people suffering this problem continues to grow.

    The first line of defense against diabetes consists of exercise and weight control. All you have to do is take a brisk walk for 30 minutes a day to drop your chances of diabetes (American Journal of Epidemiology 10/1/03).

    "We have found that men and women who incorporate activity into their lifestyles are less likely to develop type 2 diabetes than those who are sedentary. This finding holds no matter what their initial weight," said Andrea Kriska, PhD, professor of epidemiology at University of Pittsburgh Graduate School of Public Health.

    To help your body fight the development of diabetes, researchers also recommend vitamin C and natural vitamin E.

    Researchers working with lab animals at the University of California at Irvine have found that these antioxidant vitamins can help insulin (the hormone-like substance secreted by the pancreas) reduce harmful blood sugar. In addition, these vitamins shrink the chances of organ damage that can be caused by diabetes (Kidney International 1/03).

    In this investigation, these vitamins also helped reduce blood pressure, another risk factor that raises heart disease risk.

    "Blood pressure was lowered to normal, and free radicals were not in sufficient numbers to degrade the sugars, proteins and nitric oxide," notes Nick Vaziri, MD, professor of medicine at the University of California. "We think this shows that a diet rich in antioxidants may help diabetics prevent the devastating cardiovascular, kidney, neurological and other damage that are common complications of diabetes."

    Free Radical Blues

    Dr. Vaziri and his group of researchers found that untreated diabetes raised blood pressure and increased the production of free radicals, caustic molecules that can damage arteries and the heart. Free radicals can change blood sugar and other proteins into harmful substances, boosting tissue and heart destruction.

    In Dr. Vaziri's work with lab animals, he found that treating diabetes with insulin lowered blood pressure and helped keep sugar and protein from changing into dangerous chemicals, but allowed the free radicals to subvert nitric oxide, a chemical the body uses to protect itself from free radicals.

    In this investigation, adding vitamins C and E to insulin insulated the body's sugars, proteins and nitric oxide from oxidative assault. This produces a double advantage: Lowering the risk of heart disease and other damage to the body from diabetes.

    Maitake, an Oriental mushroom that has been shown to have many health benefits, can also be useful for people with diabetes who are trying to avoid cardiovascular complications. Laboratory studies in Japan demonstrate that maitake may help lower blood pressure while reducing cholesterol (Biological & Pharmaceutical Bulletin 1997; 20(7):781-5). In producing these effects, the mushroom may also help the body reduce blood sugar levels and decrease the risk of tissue damage.

    No Smoking!

    Tobacco smoke is one of the most notorious causes of heart problems. In the same way a hard frost exerts a death grip on a highway, the smoke from cigarettes can freeze up arteries and hamper their proper function. A healthy artery must stay flexible to comfortably allow adequate circulation.

    But "...when blood vessels are exposed to cigarette smoke it causes the vessels to behave like a rigid pipe rather than a flexible tube, thus the vessels can't dilate in response to increased blood flow," says David J. Bouchier-Hayes, MD, professor of surgery at the Royal College of Surgeons in Ireland, who has studied the deleterious effects of tobacco.

    This rigidity is called endothelial dysfunction. When arteries are rigid, blockages gum up vessels, clots and other impediments to blood flow appear, and your risk of heart attack and stroke increases (Circulation 2001 Nov 27; 104(22):2673).

    This condition can also cause chest pain (angina) similar to that caused by a heart attack, and should be evaluated by a knowledgeable health practitioner.

    Although all experts recommend you stop smoking to lower your heart disease risk, some studies have found that Pycnogenol(r), a pine bark extract that helps the body fight inflammation, may ease some of smoking's ill effects.

    In a study of platelets, special cells in the blood that can form dangerous blood clots, researchers found that Pycnogenol(r) discouraged platelets from sticking together (American Society for Biochemical and Molecular Biology 5/19/98). By keeping platelets flowing freely, this supplement may alleviate some of the heart-threatening clots that tobacco smoke can cause.

    In Ayurvedic medicine, a traditional therapy from India, an herb called guggul has also been used to lower the risk of blockages in arteries. This herb, derived from the resin of the mukul tree, has been shown to reduce cholesterol by about 25%. People taking this herb have also reduced their triglycerides (harmful blood fats) by the same amount (Journal Postgraduate Medicine 1991 37(3):132).

    The Female Version of Heart Disease

  • Medical experts who have examined heart disease in men and women have found some striking Differences.
  • For one thing, women often don't suffer from the crushing chest pain that for most people characterizes a heart attack; instead, many women experience back pain, sweating, extreme fatigue, lightheadedness, anxiety or indigestion, signs that can be easily misread as digestive troubles, menopausal symptoms or indicators of aging.

    The genders also differ in how heart disease poses a threat. While men seem most endangered by the buildup of blockages in arteries, women apparently are more at risk from endothelial dysfunction. But more study needs to be done since, in many cases, researchers have been unable to pin down the precise mechanism that causes many women to die of heart disease.

    Scientists have found that the number of women in their 30s and 40s who are dying from sudden cardiac arrest is growing much faster than the number of men of the same age who die of this cause. But research by the Oregon Health & Sciences University and Jesse E. Edwards Cardiovascular Registry in St. Paul, Minnesota, shows that while doctors can pinpoint the coronary blockages that kill men, they can't find specific blockages in half of the female fatalities they have studied (American Heart Journal 10/03).

    "This was an unexpected finding. However, the study underscores the need to focus on what is causing these younger women to die unexpectedly because the number of deaths continues to increase," says Sumeet Chugh, MD, a medical professor at Oregon.

    Since the failure of arteries to relax probably contributes to heart disease in many women, eating red berries, or consuming supplements from berries such as chokeberry, bilberry or elderberry, may be important in lowering women's heart disease risk. These fruits help arteries expand and allow blood to flow freely.

    Red berries are rich sources of flavonoids, polyphenols and anthocynanins. The anthocyanins are strong antioxidants that give the berries their color. Research at the Indiana University School of Medicine have found that these chemicals can interact with nitrous oxide, a chemical produced by the body, to relax blood vessels (Experimental Biology conference 5/20/02).

    Working Out

    As researchers work to devise lifestyle roadmaps that can steer you around the perils of heart disease, they are finding that exercise is a key path to avoiding cardiovascular complications.

    A 17-year study of about 10,000 Americans found that those who exercised and kept their weight down (or took weight off and kept it off) experienced a significantly lower risk of heart problems (Preventive Medicine 11/03).

    "The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, of the Albert Einstein College of Medicine in the Bronx, New York. Burning calories in physical activity may be the secret to reducing heart disease risk and living longer, she says.

    Dr. Fang's research used information collected from the First National Health and Nutrition Examination Survey in 1975 and then computed how much people exercised, how their body mass indices varied and which of these folks died of heart disease during the next two decades.

    In the study, more than 1,500 people died of heart disease. Those who worked out and consumed more calories cut their risk of heart disease death in half.

    Exercise Is Essential

    "Subjects with the lowest caloric intake, least physical activity, and who were overweight or obese had significantly higher cardiovascular mortality rates than those with high caloric intake, most physical activity, and normal weight," Dr. Fang notes. The individuals in the study who were overweight and didn't exercise had a bigger risk of heart disease even if they tried (and succeeded) at eating less.

    "This suggests that heart disease outcome was not determined by a single factor, but rather by a compound of behavioral, socioeconomic, genetic and clinical characteristics," according to Dr. Fang.

    According to researchers, if your job requires a great deal of physical activity, your health will be better if you get another job. Exercise on the job not only doesn't decrease your risk of heart disease, it may actually raise it. The reason: On-the-job activity is linked to heart-endangering increases in job stress.

    Research into this subject, performed at the Keck School of Medicine of the University of Southern California, found that while recreational exercise slowed hardening of the arteries, workers who had to exert themselves during the workday had arteries that were blocked at a younger age (American Journal of Medicine 7/03).

    In this study, researchers examined about 500 middle-aged employees as part of what is called the Los Angeles Atherosclerosis Study.

    "We found that atherosclerosis progressed significantly faster in people with greater stress, and people who were under more stress also were the ones who exercised more in their jobs," says James Dwyer, PhD, professor of preventive medicine at the Keck School. According to Dr. Dwyer, "This suggests that the apparent harmful effect of physical activity at work on atherosclerosis-and heart disease risk-may be due to the tendency of high-activity jobs to be more stressful in modern workplaces.

    "It appears from our findings that the psychological stresses associated with physically active jobs overcomes any biological benefit of the activity itself."

    Playful Workouts

    On the other hand, the scientists found that heart disease drops dramatically among those who exercise the most in their spare time. In the study, people who vigorously worked out at least three times a week had the lowest risk. But even those who just took walks enjoyed better heart health than people whose most strenuous activity was working the TV remote. Dr. Dwyer says, "These results are important because they demonstrate the very substantial and almost immediate-within one or two years-cardiovascular benefit of greater physical activity."

    Lowering your risk of heart disease is substantially up to you. Listen to what your heart tells you it needs; then, exercise your right to fetch some cardiovascular necessities.



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    Homeopathic Essentials
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    Date: June 11, 2005 05:13 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Homeopathic Essentials

    Homeopathic Essentials by Jane Lane Energy Times, February 1, 2000

    The principles of homeopathy are elegantly basic and, to some, maddeningly elusive. This system of medical treatment employs The Law of Similars or "like cures like," and calls on natural plant, animal and mineral substances that induce the body to heal itself.

    That homeopathy works is virtually incontrovertible. With its ancient roots and European practice spanning hundreds of years, homeopathy employs minute doses of diluted extracts to replicate symptoms of a malady, which then vanishes. But the very fact that it works puzzles many experts who have researched the phenomenon.

    Understanding The Tradition

    Homeopathy evolved from its earliest practice recorded by 10th-century BC Hindu sages to its codification by Hippocrates in 400 BC. " Through the like, disease is produced and through the application of the like, it is cured," he wrote, expressing the fundamental principle of homeopathy, according to Homeopathic Medicine at Home (Tarcher Perigee) by Maesimund B. Panos, MD, and Jane Heimlich. Samuel Christian Friedrich Hahnemann, the erudite and intellectually audacious German physician and chemist, seized upon the essentials of homeopathy in the early 1800s.

    Through Hahnemann's work, homeopathy developed into an intricately systematized science, veering into the arcane for the contemporary individual seeking relief for everyday ailments.

    Modern practitioners and manufacturers of homeopathic remedies benefit from Hahnemann's daring research (which included potentially lethal experiments on himself) and complex doctrines.

    They've streamlined and modernized Hahnemann's concepts to provide more relevance to modern ills and sensibilities.

    The Bold Experiments

    Hahnemann denounced the medical practices of the 18th century, which involved cauterizing, bleeding, blistering and purging patients to expel the pernicious fluids or humors believed to cause disease.

    He also reviled the kind of omnibus prescription drugs of the day, which loaded many substances into one compound. In 1790, Hahnemann conducted his groundbreaking experiment establishing the basis of homeopathy.

    The customary treatment for malaria at the time was Cinchona officinalis or Peruvian bark-quinine. Medical wisdom attributed its efficacy to its bitterness and astringency. Hahnemann rejected this explanation, noting that other botanicals are far more bitter and astringent, yet are powerless against malaria.

    To prove his theory, Hahnemann took some cinchona compound and promptly developed the symptoms of malaria. His deduction: Like cures like, or The Law of Similars. A substance that, in minute doses, induces certain symptoms in a healthy person cures a sick one.

    The Set of Laws

    A set of fairly complex laws developed from Hahnemann's initial Law of Similars.

    The Law of Proving refers to the process of ascertaining the effectiveness of a homeopathic therapy by administering a substance to a healthy person to record in minute detail its effects. Practitioners also use the standard double-blind method using a placebo or unmedicated tablet against a homeopathic compound.

    The first proving was performed in 1790 and the procedure endures today, using only humans, not laboratory animals, for greater accuracy. As homeopathic preparations are not toxic, proving has never produced lasting adverse reactions. Descriptions of provings are compiled into books called materia medicas, including Boericke's Materia Medica and Repertory and The Lectures of Homeopathic Materia by James Tyler Kent, used regularly in contemporary practice.

    The books are highly indexed collections of symptoms and the remedies that cure them called repertories. The most extensively used repertory is Kent's Repertory of the Homeopathic Materia Medica.

    In 1800, the third Law of Potentization was devised, regulating the processing of homeopathic remedies through successive dilutions and shaking.

    This law represents perhaps the profoundest mystery of homeopathy and demands the boldest leap of faith: The higher the dilution, the more intense the potency of the medicine. Substances that are inert in their natural state act as medicine. And as they are so dilute, homeopathic remedies do not act directly on the tissues, accounting for their non-toxicity. Adding to the inherent safety of homeopathic therapies is the discipline's adherence to the single remedy. Centuries ago, homeopaths seemed to have been prescient about current drug interaction troubles.

    (Historical information courtesy of Homeopathic Medicine at Home by Panos and Heimlich.)

    How It Works: The Vital Force Homeopathy embraces a philosophy centered on the concept of "vital force," an intelligent, dynamic life force within each individual responsible for maintaining one's life and balance on all levels. The vital force creates a defense mechanism similar to the immune system, but incorporates protection against imbalances on the emotional and mental planes as well.

    Homeopathy equates disease with imbalance. As the defense mechanism attempts to restore balance, symptoms appear: pain, swelling, rashes and fevers on the physical side; grief, jealousy, anxiety, anger, confusion and loss of memory on the emotional and mental end.

    Homeopaths regards these symptoms as evidence of the vital force's curative exertions, not merely annoyances to be eliminated. Symptoms guide the homeopath in his or her attempts to harmoniously augment the efforts of the vital force.

    Homeopathy Today

    Homeopathic remedies are prepared according to the standards of the United States Homeopathic Pharmacopoeia and are recognized by the US Food and Drug Administration. " Homeopathy respects the complexity and uniqueness of each individual," observes pharmacist and naturopathic doctor James LaValle (and his co-authors) in Smart Medicine for Healthier Living. "To identify the correct homeopathic remedy, you must carefully observe your unique-even quirky-behaviors and responses." Indeed the emphasis on the "unique, even quirky" may lead to the perception of homeopathy as a sketchy pseudo-science. Homeopathy simply does not fit the drug model of allopathic medicine.

    Its ability to help people, however, has been repeatedly evaluated through rigorous scientific research. A comprehensive review in the British Medical Journal (302, 1991: 316-323) of more than 100 clinical studies of homeopathy published during the last 30 years revealed that 77% of those studies produced positive results for the people involved. A host of additional studies provides clinical evidence:

  • • A fixed combination of three plant substances (Phytolacca americana, Guajacum officinale and Capsicum annuum) significantly decreased the symptoms of acute tonsillitis in 107 sufferers, who took no antibiotics. The anti-inflammatory, immunomodulatory and analgesic properties produced no side effects (Adv Ther 15, 1998: 362-71).
  • • An article in the Journal of Nurse Midwifery (44, 1999: 280-90) explains the use of 19 homeopathic remedies that aid breastfeeding.
  • • "The practice of (homeopathic) preventive antepartum care of pregnant women, adopted at the beginning of this century, has reduced perinatal mortality and the rates of low birth weights and preterm weights. . .Studies on homeopathic interventions in obstetrics report positive influence of homeopathic remedies on uterine contractility and the evolution of childbirth. The only study comparing homeopathic and conventional therapy in women with increased risk for contraction abnormalities found few Differences between the treatments, except fewer hemorrhages and decreased abnormal contractions in patients treated with homeopathic remedies (Schweiz Med Wochenschr Suppl 62, 1994: 28-35).
  • • A homeopathic remedy proved as effective as prescription betahistine hydrochloride in treating folks with vertigo (Arch Otolaryngol Head Neck Surg 124, 1998: 879-85). n Single, individualized homeopathic remedies demonstrated potential efficacy in HIV infection during its symptomatic period (Br Homeopath J 88, 1999: 49-57). The remedies produced a "statistically significant" elevation in base line immune status.
  • • And, finally, a study in the prestigious international medical journal The Lancet (September 20, 1997) claimed that researchers' findings and conclusions "are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo" but called for more "rigorous. . .systematic" research on homeopathy.



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    The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
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    Date: June 09, 2005 05:22 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

    The Latest Breakthroughs in Garlic Research

    on Cancer and Cardiovascular Disease

    Presented at the 2005 World Garlic Symposium

    Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

    “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

    Presentation highlights included:

  • • Clinical Intervention Trial and pre-clinical substantiation on Cancer using Garlic, presented by National Cancer Institute scientists, Mitchell Gail and John Milner Mounting evidence points to the anticancer properties of aged garlic extract and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis.

  • • Inhibition of Coronary Arterial Plaque Accumulation by Garlic, presented by Matthew Budoff, Harbor-UCLA Medical Center

    Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.

  • • Influence of Garlic on Endothelial Dysfunction in Hyperhomocysteinemia, presented by Norbert Weiss, University of Munich in Germany Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute high homocysteine on endothelium-dependent brachial artery vasodilatation and on acetylcholine-induced stimulation of skin perfusion.

  • • Anti-glycation properties of aged garlic extract: possible role in prevention of diabetic complications, presented by Nessar Ahmed, Manchester Metropolitan University in England Aged garlic extract inhibited the formation of advanced glycation end products, which have been previously shown to increase the risk of diabetic complications ranging from heart disease to retinopathy, kidney failure, impaired wound healing and many more.

    “Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

    Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

    Abstracts

    PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

    Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable Differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

    INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

    Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

    INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

    Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

    Bibliographies

    David Heber, MD, PhD, FACP, FACN

    Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

    Matthew Budoff, MD, FACC

    Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.



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    Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...
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    Date: May 24, 2005 09:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...

    Cognitive Improvement in Mild to Moderate Alzheimer's Dementia After Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Maria De Jesus Moreno Moreno, MD Instituto Nacional de la Senectud, Mexico City, Mexico


    This study assessed the efficacy and tolerability of the cholinergic precursor choline alfoscerate (CA) in the treatment of cognitive impairment due to mild to moderate AD (Alzheimer's disease).

    in both men and woman they consistently improved after 90 and 180 days versus baseline with adiministration of GPC three times a day, whereas in the placebo group they remained unchanged or worsened. Statistically significant Differences were observed between treatments after 90 and 180 days.

    Keypoints:

  • improved cognition and global function
  • showed a statistically significant improvement after 90 and 180 days of treatment
  • Increased neurotransmission
  • With out treatment men and woman declined consistantly
  • references:

    Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction, Science. 1982;217:408-414. 2. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: Dementia and Alzheimer's disease. Annu Rev Public Health. 1992;13:431-449. 3. Hofman A, Rocca WA, Brayne C, et al, for the European Prevalence Research Group. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int d Epidemiol. 1991;20:736-748. 4. Blackwood W, Corsellis JAN, eds. Greenfield's Neuropathology. 3rd ed. London: Arnold; 1976. 5. Geldmacher DS. Cost-effective recognition and diagnosis of dementia. 5emin Neurol. 2002;22:63-70. 6. Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 1978;2:1457-1459. 7. Perry EK. The cholinergic hypothesis--ten years on. Br Med Bull. 1986;42:63-69. 8. Giacobini E. From molecular structure to Alzheimer therapy. Jpn d Pharmacol. 1997;74:225-241. 9. Giacobini E. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications. Neurochem Int. 1998;32:413-419. 10. Brinkman SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's disease. J Gerontol. 1982;37:4-9. 11. Davis E, Emmerling MR, Jaen JC, et al. Therapeutic intervention in dementia. Crit Rev Neurobiol. 1993;7:41-83. 12. Amenta E Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropiate approaches? Mech Ageing Dev. 2001;122:2025-2040. 13. Sigala S, Imperato A, Rizzonelli P, et al. k-Alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eurd Pharmacol. 1992;211:351-358. 14. Govoni S, Battaini E Lucchi L, et al. Effects of alpha-glycerylphosphorylcholine in counteracting drug-induced amnesia: Through cholinergic and non-cholinergic mechanisms [in Italian]. Basi Raz Ter. 1991;21:75-78. 15. Canonico PL, Nicoletti F, Scapagnini U. Neurochemical and behavioral effects of alpha-glycerylphosphorylcholine [in Italian]. Basi Raz Te~ 1990;20: 53-54. 191 CLINICAL THERAPEUTICS ® 16. Parnetti L, Amenta E Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: An analysis of published clinical data. Mech Ageing Dev. 2001;122:2041-2055. 17. Venn RD. The Sandoz Clinical Assessment-Geriatric (SCAG) scale. A general-purpose psychogeriatric rating scale. Gerontology. 1983;29:185-198. 18. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991;19:330-341. 19. Frattola L, Piolti R, Bassi S, et al. Multicenter clinical comparison of the effects of choline alphoscerate and cytidine diphosphocholine in the treatment of multi-infarct dementia. Curt Ther Res Clin Exp. 1991;49:683-693. 20. Muratorio A, Bonuccelli U, Nuti A, et al. A neurotropic approach to the treatment of multi-infarct dementia using L-c~-glycerylphosphorylcholine. Curt Ther Res Clin Exp. 1992;52:741-75l. 21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: APA; 1994. 22. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944. 23. Folstein ME Folstein SE. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198. 24. Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke. 1983;14:399-401. 25. Hamilton M. A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960;23:56-62. 26. Hamilton M. Development of a rating scale for primary depressive illness. BrJ Soc Clin Psych& 1967;6:278-296. 27. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. AmJ Psychiatry. 1984;141:1356-1364. 28. Reisberg B, Ferris SH, De Leon MJ, et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136-1139. 29. National Institute of Mental Health. Clinical global impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Revised edition. Rockville, Md: National Institute of Mental Health; 1976:217-222. 30. Burns A, Russell E, Page S. New drugs for Alzheimer's disease. Br J Psychiatry. 1999;174:476-479. 31. Kumar V, Anand R, Messina J, et al. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159-169. 32. Knapp MJ, Knopman DS, Solomon PR, et al, for the Tacrine Study Group. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 1994;271:985-991. 192 M. Moreno 33. Lindstrom MJ, Bates DM. Newton-Rapshon algorithms for linear-mixed effects models for repeated measure data. J Am Stat Assoc. 1998;83:1014-1022. 34. Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-711. 35. Rogers SL, Friedhoff LT, for the Donepezil Study Group. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia. 1996;7:293-303. 36. Rogers SL, Doody RS, Mohs RC, Friedhoff LT, for the Donepezil Study Group. Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Arch Intern Med. 1998; 158:1021-1031. 37. Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group. A randomized trial evaluating the efficacy and the safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1998;1:55-65. 38. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial. BMJ. 1999;318: 633-638. 39. Amenta E Bronzetti E, Del Valle M, Vega JA. Effects of alpha-glycerylphosphorylcholine in neuroanatomy of aging brain in experimental animals [in Italian]. Basi Raz Te~: 1990;20:31-38. Address correspondence to: Scientific Department, Italfarmaco SpA, via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy.

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    KudZu, Treatment of alcohol dependence or alcohol abuse
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    Date: May 19, 2005 09:29 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: KudZu, Treatment of alcohol dependence or alcohol abuse

    For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.

    Alcohol abuse

    Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.

    While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.

    Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:

    CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH

    In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:

    CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH

    Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual Differences in alcohol tolerance might well be based on both qualitative and quantitative Differences in isozyme endowment (Vallee, 1966, supra).

    Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.

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    Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic
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    Date: May 18, 2005 09:20 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic

    Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.

    Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension. Material and Methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.

    Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major Differences were in the types and proportions of individual oils contributing to a given formula.

    Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity. Keywords: diabetes mellitus, essential oils, insulin resistance, insulin sensitivity, insulin sensitivity, natural products Received 11 August 2003; returned for revision 25 September 2003; revised version accepted 16 March 2004 Introduction The prevalence of insulin resistance and its most severe form type 2 diabetes mellitus is rapidly increasing in the USA – even throughout the world [1–3]. The recent increase is attributed, at least to some extent, to the greater occurrence of overweight and obesity that is due mainly to an augmented intake of calories and refined carbohydrates, lesser consumption of fibres and a more sedentary lifestyle [4–6]. Obviously, reversal of these situations should ameliorate the problem. Unfortunately, more is often needed than simply advising lifestyle changes that frequently fail in order to combat insulin resistance and its accompanying perturbations (cardiovascular diseases, obesity, dyslipidemias, diabetes mellitus and premature ageing) [7,8]. Experience shows that the afflicted not infrequently require aids to help with the maintenance of a healthful lifestyle. Correspondence: Harry G. Preuss, D, Georgetown University Medical Center, Department of Physiology and Biophysics, Basic Science Building, Room 231B, 4000 Reservoir Road, N.W., Washington, DC 20057, USA. O R I G I N A L ART I C L E doi: 10.1111/j.1463–1326.2004.00386.x # 2004 Blackwell Publishing Ltd Diabetes, Obesity and Metabolism, 7, 2005, 193–199 193

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    Important Information for Allergy Sufferers
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    Date: May 13, 2005 09:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Important Information for Allergy Sufferers

    Important Information for Allergy Sufferers

    Richard Conant, L.Ac. C.N.

    Imagine you are one among millions who greet each spring with worry about the flood of pollen that fills the air this time of year. When the pollen season arrives, as it inevitably does, you find yourself with two choices. You can either take over-the-counter antihistamines and put up with unpleasant side-effects, or endure the sneezing, runny nose, itchy, watery eyes and other discomforts of hay fever.

    If there was a natural ingredient, a nutritional substance found throughout nature in many foods and plants, that could offer an alternative, would you not be interested?

    Quercetin, one among hundreds of flavonoids found throughout the plant kingdom, is this ingredient. Quercetin has been researched in numerous pharmacological studies. The results of this work strongly suggest that quercetin helps to stabilize the fundamental process in the body which causes an allergic reaction. Quercetin, as shown in test-tube ("in vitro") studies, prevents the release of histamine from "mast cells," immune cells that stand guard in the tissues which meet the outside environment—the nasal passages, the lungs, the digestive tract and skin. While this has yet to be confirmed by human clinical trials, in the picture that emerges from the research so far, quercetin looks like a rescue nutrient for allergy sufferers.

    Reports from Quercetin Users

    I have seen numerous reports from individuals who have indeed achieved significant reductions in allergic sensitivity by using quercetin. And this includes food allergies as well as environmental allergies. Anecdotal stories like these carry little weight among scientists, because they do not provide evidence that the observed result will be repeated in other cases. Only placebo-controlled, double-blind studies can produce this kind of scientific proof. Yet, when anectodal evidence (this includes physician "case reports") correlates with the results of pharmacological research such as we have on quercetin, I believe it should be taken seriously. And quercetin is a nutrient that works effectively when taken as a dietary supplement.

    For example, one gentleman writes that his wife, who is allergic to pollen and dust, is now "sneeze-free" after using quercetin for three years. A Pennsylvania woman writes that her husband, also a long time allergy sufferer, "seems to be nearly allergy free" after one month of use. Another man says that "quercetin has literally changed my life." These are not isolated cases; a respected nutritionist who specializes in allergies and environmental problems has seen many similar outcomes with a quercetin. Clearly something significant is going on with respect to quercetin as a nutritional approach for overcoming allergies.

    Bear in mind, though, that quercetin does not function like an antihistamine medication; it is not a quick fix. As a nutrient that helps to normalize body functions naturally, quercetin needs time to work, and should be taken for at least two or three weeks to achieve these results.

    Quercetin Quiets the Allergic Response

    Exerting a broad range of biological effects, quercetin is perhaps the most active and versatile flavonoid. In test-tube studies, quercetin acts directly on the mast cell in a way that quiets the allergic response.

    An allergic reaction occurs when IgE antibodies, positioned on the mast cell surface, come in contact with a potential allergy-causing substance like pollen. The mast cell is then signaled to release histamine from storage granules located inside the cell, through a process called "degranulation." The histamine circulates throughout the body, causing the runny nose, itching and other discomforts associated with allergies.

    Quercetin stabilizes mast cell membranes, in effect turning down the allergic response signal. Quercetin also slows other mechanisms which are involved with inflammation, such as the production of inflammatory prostaglandins and leukotrienes. This adds to its membrane-stabilizing effect, and its value in allergy control.

    Quercetin appears to substantially raise the threshold for initiation of an allergic reaction. In allergy sufferers this threshold is low, for reasons which are not well understood. They may have more IgE antibodies than normal, making the mast cells overly "trigger happy." Histamine has its proper place in the immune response that defends us against truly harmful foreign substances in the body. But like many chemicals produced by the body, histamine is a two-edged sword. In allergy-prone individuals, the mast cells have become overreactive, releasing too much histamine, unnecessarily. With quercetin in the bloodstream, histamine release from mast cells is kept under control. Quercetin's ability to down-regulate both the inflammatory and allergic responses makes it, I believe, a highly important nutrient for humans to consume on a regular basis.

    Quercetin-the Scientific Evidence

    Several studies, published in respected journals such as the Journal of Allergy and Clinical Immunology and others, have demonstrated quercetin's ability to control the release of histamine from mast cells. (Quercetin has the same effect on basophils, a type of white blood cell that also contains histamine.) In these experiments, mast cells taken from both animals and humans are exposed in the test tube to various substances—called "antigens"— that stimulate histamine release. The researchers then add an inhibiting agent such as quercetin to the mixture and measure the Differences in histamine output. Quercetin has shown itself to be one of the more powerful histamine inhibitors, more powerful, in fact, than disodium cromoglycate, an anti-asthma drug.

    Quercetin has other beneficial properties. A strong antioxidant, Quercetin has a higher level of antioxidant activity than both vitamin C and vitamin E. (Quercetin enhances the antioxidant activity of vitamin C; quercetin and vitamin C are true synergists.) Quercetin has been shown to block the oxidation of LDL cholesterol by free radicals. Quercetin also protects cell membranes from being injured by oxidized LDL. The damage that oxidized LDL causes to the delicate membranes of blood vessel linings allows plaque deposits to form, setting the stage for atheroslcerosis. These observations point to quercetin as a key nutrient for maintaining cardiovascular health.

    Like all flavonoids, quercetin is not classified as an essential nutrient, although flavonoids were once called "Vitamin P." In view of its many beneficial actions, quercetin is a nutrient that clearly has important roles to play in human nutrition, for allergy sufferers, and for everyone.

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    Garlic Extract Modulation or Pulmonary Vascular Function:
    TopPreviousNext

    Date: May 12, 2005 12:41 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Garlic Extract Modulation or Pulmonary Vascular Function:

    Garlic Extract Modulation or Pulmonary Vascular Function: Comparisons Among Fresh, Aged, Freeze-dried Powder and Oil Macerate

    Author:
    Ku DD, Abdel-Razek TT, Dai J, Fallon MB, Abrams GA

    Source:
    FASEB Journal, 1998

    Abstract:
    Garlic has been advocated for a variety of therapeutic applications including pulmonary vasodiladon, but definitive experimental evidence supporting these claims remain inconclusive. We compared the relative vasorelaxation efficacv of fresh garlic extract (FG) to those commercially packaged garlics on rat pulmonary artery (PA) rings. Water extract of fresh whole garlic (1-500 µg/ml) produced a dose-dependent relaxation in endothelium (EC)-intact (PA, reaching a maximum of -62±4% (M±SE of 18 rings). Maximum relaxation observed with the garlic storage leaves (-79.±4%, n=16 rings) was significantly higher than the garlic inner stem (-48±5%, n=12 rings). Boiling of garlic extracts at l00ºC for 30 mins reduced the relaxation by 10-20%. Mechanical disruption of EC or pretreatment with L-NAME, reduced the relaxation by 30-40%. Extracts from freeze-dried powder (Garliquc; Pure-Gar and Kwai), aged garlic (Garlique), and garlic oil macerate (Softgel) resulted in -87±3% (n=16 rings), -72±6% (n=30 rings), -45±3% (n=30 rings), -22±5% (n=14 rings) and -5±3% (n=14 rings relaxation, respectively. Vasoinhibitory effect of FG extract was readily reversible upon washing, whereas the Pure-Gar and Garlique effects tended to be longer lasting and PA contractile response remained depressed even after 60-min washing. These results show that extracts of both fresh and freeze-dried garlic, but not the oil macerate, are capable eliciting both EC-dependent and -independent relaxation in rat PA. Differences in vasorelaxant potency may be related to the concentrations of the garlic active ingredient, allicin, in different garlic preparations.


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    Garlic Consumption and Cancer Prevention...
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    Date: May 12, 2005 12:34 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Garlic Consumption and Cancer Prevention...

    Garlic Consumption and Cancer Prevention: Meta-Analyses of Colorectal and Stomach Cancers

    Author:
    Fleischauer AT, Poole C, Arab L

    Source:
    Am J Clin Nutr. 2000;72:1047-1052.

    Abstract:
    BACKGROUND: Animal and in vitro studies have provided evidence of an anticarcinogenic effect of active ingredients in garlic.
    OBJECTIVE: The objective was to conduct meta-analyses of the epidemiologic literature on the association between garlic consumption and risk of stomach, colon, head and neck, lung, breast, and prostate cancers.


    DESIGN: Meta-analyses were conducted for all cancers mutually and separately for colorectal and stomach cancers in relation to consumption of exclusively raw garlic, cooked garlic, or both (RC garlic). Eighteen studies reported a relative risk estimate for RC garlic consumption and cancer risk.


    RESULTS: In the meta-analyses of colorectal and stomach cancer, the reference categories ranged from no consumption to consumption of 3.5 g/wk, whereas the highest categories ranged from any consumption to >28.8 g/wk. The average difference between the highest and lowest categories was 16 g/wk. The random-effects relative risk (RR) estimate of colorectal cancer and RC garlic consumption, excluding garlic supplements, was 0.69 (95% CI: 0.55, 0.89). For stomach cancer, the random effects RR estimate was 0.53 (95% CI: 0.31, 0.92). The heterogeneity among studies for the latter outcome (P = 0.0002) indicates the questionableness of the generalizability of this summary estimate. An indication of publication bias for all cancers combined is evident from a funnel plot of RC garlic consumption and cancer risk and from the results of the Begg and Mazumdar test (P = 0.049).


    CONCLUSIONS: High intake of RC garlic may be associated with a protective effect against stomach and colorectal cancers. Heterogeneity of effect estimates, Differences in dose estimation, publication bias, and possible alternative hypotheses (eg, confounding by total vegetable consumption) preclude sole reliance on summary effect estimates.
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    Under-Reported (and Underappreciated) Cholesterol control.
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    Date: May 12, 2005 10:00 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Under-Reported (and Underappreciated) Cholesterol control.

    Under-Reported (and Underappreciated) Solutions for Cholesterol and Triglyceride Control

    by Richard Conant, L.Ac., C.N.

    Fat and human existence are inseparable. Setting aside the fear and loathing over fat in the body that pervades our culture, we understand that fat is our friend. We cannot live without fat.

    The human body contains many different kinds of fats and fat-like molecules. Collectively known as "lipids" these fatty substances include fatty acids, lipoproteins, phospholipids, glycolipids, triglycerides, steroid hormones and the infamous, dreaded cholesterol.

    Lipids (fats) are found everywhere in the body, performing a variety of vital functions. The brain is a fat-rich organ. Brain neurons and all other nerve cells are protected by a myelin sheath, made largely out of fatty material. Cell membranes consist almost entirely of phospholipids (lipids that contain phosphorus) arranged in a sandwich-like double layer embedded with proteins. Sex hormones are lipids, belonging to the group of complex lipid molecules known as "steroids." Vitamin D is a lipid.

    The body stores and transports fatty acids in the form of triglycerides. A triglyceride contains three fatty acid molecules, which have a chain-like structure, linked to glycerol. (There are also mono- and di-glycerides, which have one and two fatty acid chains, respectively, attached to glycerol.)

    Like many other things necessary to life, fat is a two-edged sword. Fat insulates us from the cold, cushions and protects our vital organs and serves as a storehouse for energy. Yet, when present in excess to the point of obesity, fat threatens health, happiness, self-esteem, social standing and longevity. The same is true of other lipids, most notably triglycerides and cholesterol. Transported throughout the body in the bloodstream, these essential lipids become a health liability when the blood contains too much of them.

    Keeping fat in it its proper place, not eliminating or drastically reducing it, is the goal we should seek. In the blood, lipids must be maintained at healthy levels and ratios. When they are, an important foundation of good health is established.

    How do we keep the blood lipids we need——triglycerides and the various forms of cholesterol——balanced at healthy levels? Diet and exercise are indispensable, these basics must come first. Along with the recommended dietary practices, a number of nutritional approaches offer help for maintaining healthy blood lipids. We will now give several of these a closer look.

    Gugulipid

    In 1990, an herb used for centuries in the Far East was introduced to U.S. consumers. This herb, called "gum guggul," is proving to be one of the most effective natural cholesterol-lowering agents ever discovered. It also brings triglycerides down and raises HDL, the "good" cholesterol. The changes are substantial; gum guggul single-handedly normalizes the entire blood lipid profile, even in people with high starting levels of cholesterol and triglycerides.

    Gum guggul, also called simply "guggul," is a gummy resin tapped from the Commiphora tree. A cousin of myrrh gum, guggul has been used by Ayurvedic herbalists of India for at least 3,000 years; texts dating from around 1,000 B.C. mention the herb. Guggul was traditionally given for rheumatism and poor health caused by excess consumption of fatty foods. One ancient Sanskrit text describes in detail what happens in the body when blood fats are out of balance, due to sedentary lifestyle and overeating. The name of this condition has been translated as "coating and obstruction of channels."

    Intrigued by the obvious similarity between "coating and obstruction of channels" and arteries clogged by fatty plaque, Indian researchers initiated a series of experimental and clinical studies in the 1960's to see if gum guggul would lower excess blood lipids.1 Both human and animal studies consistently showed cholesterol and triglyceride reductions.

    Detailed pharmacological studies showed that guggul's lipid-lowering effects are produced by compounds in the resin called "guggulsterones."2 An Indian pharmaceutical firm then patented a standardized extract of gum guggul under the trade name "Gugulipid." The product contains a uniform 2.5 percent guggulsterones, which is higher than guggul resin in its natural state.

    Because Gugulipid guarantees the necessary intake of guggulsterones needed for blood fat reduction, it has become the product used in clinical research. Phase I efficacy safety trials and Phase II efficacy trials have yielded more positive data.3,4,5 Most of the studies on gum guggul have used relatively small numbers of subjects; this tends to make mainstream medical scientists reluctant about natural remedies. A large, well-publicized double-blind Gugulipid trial on 400 to 500 people would go a long way toward giving this herb the credibility it deserves.

    Pantethine

    Another effective natural solution for blood fat control that should be better known is a relative of pantothenic acid (vitamin B5). Pantethine is the active form of pantothenic acid in the body. Pantethine forms CoA, an essential co-enzyme for utilization of fat. CoA transports "active acetate," an important byproduct of fat metabolism that provides fuel for generating cellular energy. By promoting the burning of fats for energy, pantethine helps keep triglyceride levels down.6 Pantethine also helps regulate cholesterol production, by facilitating the conversion of fat into other lipid-based molecules needed in the body.6

    Japanese researchers began studying the effect of pantethine on blood fats nearly twenty years ago. They reported their promising results at the Seventh International Symposium on Drugs Affecting Lipid Metabolism, held in Milan, Italy in 1980.7 Few in the medical or scientific communities took notice. Italian researchers followed up with several small clinical trials that confirmed the preliminary reports.6,8,9 An excellent cholesterol and triglyceride lowering agent that is safe and free of side-effects, pantethine remains, for the most part, ignored by mainstream science, although its usage is growing in alternative medicine circles. Pantethine it will no doubt prove to be one of the most important supplements for maintaining healthy blood fat levels.

    Niacin

    When taken in high enough doses, niacin (vitamin B3) substantially lowers cholesterol. This has been known to medical science for many years.10 studies on niacin as a cholesterol-lowering agent go back to the 1950's. There was a fair amount of initial enthusiasm for niacin because it improves, unlike most lipid-lowering drugs, all parameters of the blood lipid profile. Niacin reduces total cholesterol, LDL cholesterol and triglycerides. It also raises HDL cholesterol quite well. Interest in niacin has faded, in part because the necessary dose, 1200 milligrams a day or more, can cause flushing and gastrointestinal disturbances. Very high doses may be harmful to the liver if taken for too long.

    There is a solution to the side-effect problem with niacin which, again, has failed to gain widespread attention. Inositol hexanicotinate is a flush-free form of niacin composed of six niacin molecules bonded to one molecule of inositol, another B-complex nutrient. Absorbed as an intact structure, inositol hexanicotinate is metabolized slowly, releasing free niacin into the bloodstream over a period of hours following ingestion.11 Inositol hexanicotinate has all the benefits of niacin for controlling blood fats. The flushing effect of ordinary niacin, which metabolizes much more rapidly, does not occur. Taking as much as four grams per day has not been reported to raise liver enzymes or cause other side-effects, but prudence dictates that people with liver problems should avoid very high doses of inositol hexanicotinate, or any form of niacin.12

    Tocotrienols

    We often think of vitamin E as synonymous with d-alpha tocopherol. Vitamin E is actually a whole family of compounds that includes various tocopherols and a group of lesser known but highly beneficial substances called "tocotrienols." All have vitamin E activity. Tocotrienols are similar in chemical structure to tocopherols, but they have important Differences which give them unique and highly beneficial properties for human health.

    Vitamin E is one of the most recognized antioxidants, nutrients that deactivate potentially toxic byproducts of oxygen metabolism known as free radicals. Vitamin E neutralizes peroxides, which result from the free radical oxidation of lipids, making it a key antioxidant in cell membranes. While d-alpha tocopherol has generally been regarded as the form of vitamin E with the strongest antioxidant activity, tocotrienols are even stronger.

    The tocotrienol story is another example of a natural product slow to gain recognition. A Univeristy of California research team discovered that d-alpha tocotrienol is over six times more effective than d-alpha tocopherol at protecting cell membranes against free radical damage.13 In the presence of vitamin C, which recycles vitamin E-like compounds, its antioxidant activity is 40 to 60 times higher than d-alpha tocopherol. This study was published in 1991. Its safe to say few cardiac physicians know about tocotrienols, and we have yet to see 60 Minutes do a piece on "the powerful new form of vitamin E."

    It would be a tremendous service to public health if they did, because the benefits of tocotrienols go far beyond their stellar antioxidant ability. Tocotrienols also lower total cholesterol and LDL, by impressive percentages. In one double-blind controlled study, tocotrienols reduced total cholesterol by 16 percent and LDL by 21 percent after twelve weeks. Another study recorded drops of 15 to 22 percent in total cholesterol along with 10 to 20 percent decreases in LDL levels.14 Now appearing on health food store shelves, tocotrienols are a health-protecting nutrients whose long overdue time has come. Derived from food oils such as palm oil and rice bran oil, tocotrienols have the same lack of toxicity as ordinary vitamin E.

    References

    1. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.

    2. Dev, S. A modern look at an age-old Ayurvedic drug—guggulu. Science Age July 1987:13-18.

    3. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.

    4. Agarwal, R.C. et. al. Clinical trial of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.

    5. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.

    6. Maggi, G.C., Donati, C., Criscuoli, G. Pantethine: A physiological lipomodulating agent, in the treatment of hyperlipidemias. Current Therapeutic Research 1982;32(3):380-86.

    7. Kimura, S., Furukawa, Y., Wakasugi, J. Effects of pantethine on the serum lipoprotiens in rats fed a high cholesterol diet (Abstract) Seventh International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1980.

    8. Arsenio, L. Bodria, P. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clinical Therapeutics 1986;8(5):537-45.

    9. Avogaro, P. Bittolo Bon, G. Fusello, M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Current Therapeutic Research 1983;33(3):488-93.

    10. Crouse, J.R. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coronary Artery Disease 1996;7(4):321-26.

    11. Welsh, A.L. Ede, M. Inositol hexanicotinate for improved nicotinic acid therapy. International Record of Food Medicine 1961;174(1):9-15.

    12. "Inositol hexaniacinate" (Monograph). Alternative Medicine Review 1998;3(3):222-3.

    13. Serbinova, E., et. al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha tocotrienol. Free Radical Biology and Medicine 1991;10:263-275.

    14. Qureshi, N. Qureshi, A.A. Tocotrienols: Novel Hypercholesterolemic Agents with Antioxidant Properties. in 'Vitamin E in Health and Disease' Lester Packer and Jürgen Fuchs, Editors. 1993; New York: Marcel Dekker, Inc.

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