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What Is the Life Span Of Human Cells And How Do Antioxidants Help?
August 25, 2011 10:38 AM
The human body is composed of many different cells. These cells have varying functions as well as life span. The human cells, in general, are very complex. Some cells may last only within a day while others may be for life. Like for example, one blood component known as neutrophil lasts only within 24 hours. On the other hand, another blood component which is red blood cell has a life span of 120 days. One human cell which lasts for a lifetime is the stem cell. Stem cells are undifferentiated cells which are the source of blood cells. They supply the body throughout life both with red and white blood cells. Here is a brief outline of some cells of the human body with their corresponding life spans.
1. Granulocytes such as eosinophils, basophils and neutrophils – half day to 3 days
2. Stomach and colon lining cells – 2 to 4 days
3. Sperm cells – 2 to 3 days
4. Epithelial cells of the small intestines – 5 to 7 days
5. Platelets – 10 days
6. Skin epidermal cells – 14 to 28 days
7. Lymphocytes, macrophages and endothelial cells – 2 months to a year, but may vary
8. Pancreatic cells – a year or more
9. Bone cells – 25 to 30 years
As shown above, these human cells have an expected time of death. However, if the body is exposed to harmful toxins, their life span significantly decreases. As we know for a fact, the body undergoes many biological reactions almost every second. The reaction is called oxidation process which is essential to the body. However, such reaction has harmful by – products in the form of free radicals. Free radicals can cause the body significant damage. Free radicals can cause destruction and death of the healthy cells of the body and also affect the body’s cellular division. This kind of chemicals can potentially tamper DNA replication during cell division. Once cellular division is tampered, abnormal growths would likely happen. Aside from the naturally occurring free radicals, external stressors can also cause damage to the cells of the body. Some of these include pollutants, harmful chemicals and irritants. These harmful chemicals can potentially lead to the development of certain disease conditions such as heart diseases, stroke and cancer.
Fortunately, there are many antioxidants which can greatly help in the prevention of free radical damage by protecting the cells of the body. Antioxidants are molecules which can effectively prevent the oxidation of other molecules. There are many natural antioxidants found among plants and animals. Some common antioxidants are glutathione, vitamin C and vitamin E. Other nutrients which have antioxidative property include beta – carotene, lutein, lycopene, vitamin A and selenium. Fruits and vegetables are great sources of antioxidants. Nuts, grains, meat, poultry products and fish are also good sources of such cell – protecting chemicals. In addition, dietary supplements of antioxidants are also widely available in the market. However, health experts highly suggest that before supplementation of antioxidants, medical evaluation must be done first to be completely safe.
What Makes a Good Probiotic Supplement?
August 09, 2011 01:27 PM
Probiotics refer to a group of microorganisms that help maintain homeostasis in the digestive tract and even produce vitamins, minerals, and other nutrients. Nutrition experts have long recommended the consumptions of friendly bacteria as they curb the populations of harmful pathogens in the gut. More importantly, studies have shown that they contribute to the prevention of gastrointestinal disorders.
Scientists have identified a diverse variety of bacteria and yeasts that work as microbes. Bacteria that manufacture lactic acid are the most commonly used probiotics in the food and drug industries. They comprise a large number of Gram positive and acid tolerant bacteria that are generally recognized as safe. Most of the species are utilized in the production of yogurt in addition to nutritional supplements.
Multi-strain probiotic supplements are deemed better, though most products contain only one strain of bacteria. Nonetheless, they all work on the same principle. Apart from the fact that they produce lactic acid, almost all strains available in the market possess the enzymes responsible for the synthesis of lactase. Hence, probiotics give special benefits to individuals suffering from lactose intolerance.
Lactobacillus is the genus of bacteria best known as probiotics. They are the most extensively studied of all microorganisms identified to be beneficial for human beings. It is an established fact that they provide a steady supply of nutrients. Their fermentation activity in the gut enables them to synthesize vitamin K and other organic compounds that promote healthy metabolism and lower blood lipid levels.
Some strains prevent constipation, diarrhea, indigestion, and many other disorders of the digestive tract. For one, probiotics are capable of digesting complex carbohydrates that usually pass the small intestines largely unchanged. These compounds are beneficial for blood sugar. The by-products add bulk to stool, speed up the passage of fecal matter in the colon, and promote regular bowel movement.
There are strains that release natural antibiotics called bacteriocin. These compounds either directly kill pathogenic microbes present in the gut or suppress protein synthesis necessary for their survival. By so doing, probiotics curtail population growth of harmful bacteria that are often incriminated in the disease activity of ulcerations in the alimentary canal and complications of inflammatory illnesses.
Due to the fact that each strain provides unique benefits to health, it is best to choose a probiotic supplement that contains several strains of friendly bacteria. It is also important to read on the total bacterial count the product promises to deliver. Medical professionals caution the supplementation of probiotics with very high amounts of bacteria as they may disrupt the natural pH in the digestive tract.
Probiotic supplements that require refrigeration are usually not shelf-stable, and thus its quality is likely to get compromised during shipment. There are products that use sustained release technology and formulated to withstand the acidic environment of the stomach. Experts believe that releasing probiotics in the intestines helps as friendly bacteria take up residence in the gut.
Do you Suffer from Varicose Veins? There Is A Remedy!
February 03, 2011 01:10 PM
Over 12 million people suffer from varicose veins in the US alone, and leg veins in particular are expected to appear by the time women turn 50. There is nothing pleasant about having varicose veins, and complications are not uncommon, giving rise to venous ulcers and even cancerous tissues. The good news is that a treatment proven to be safe and effective has been around for years with the use of horse chestnut seed extract or HCSE as made available by pharmaceutical companies.
Veins may develop conditions leading to the impairment of its functions. Unlike arteries, veins pump blood back to the heart, and acting against gravity bear the weight of the blood coming from the lower extremities. This seems to be a real burden to the veins in the legs, but the vascular walls of all veins have special valves to accomplish this feat. To avoid blood flow moving against the programmed current inside the veins, leaflets of the valves fold and close up as blood passes.
A medical condition called chronic venous insufficiency explains the appearance of varicose veins. Veins anywhere in the body can get inflicted with the same symptoms made evident by varicose veins, but the latter is more noticeable because it lies close to the surface of the skin. The valves inside the venous system must be able to act against the turbulence that may occur inside the tube, and when they don’t, blood flow literally descends into chaos, putting an added pressure on the vascular walls.
The resulting dilated veins are what we refer to as varicose veins, which is just one symptom of chronic venous insufficiency. Age is one major factor in the development of this medical condition. It is a fact that the valves inside the leg veins are more susceptible to decreasing elasticity as we age due to daily wear and tear the veins in the legs has to endure over the years. Since female hormones contribute to the relaxing of the vascular walls, varicose veins are more likely to afflict women.
For most women, varicose veins must be remedied to avoid the social implications they bring. However, there are a number of patients that are plagued with a variety of complications. Some women practically lose the ability to stand or walk for otherwise short stretches of time, significantly affecting their productivity at work. More severe cases include the formation of skin ulcers close to the area of varicose veins, which may worsen into necrosis or skin loss.
All the debilitating effects of varicose veins can be countered by intake of horse chestnut seed extract, including of course the removal of ugly leg veins. Standardized dosage of horse chestnut is among the best remedies for chronic venous insufficiency, accounting for innumerable positive results that have been documented in recent years minus the side effects commonly associated with other medications. In fact, medical professionals in Europe largely rely on the use of horse chestnut to correct varicose veins.
Best Digestive Supplements
December 08, 2010 05:30 PM
When you need to decide on a digestive enzyme supplement, it's important to know that not all of them are created equally. Some may contain more of one ingredient than the other and some might only contain one of three groups of enzymes. A leading digestive enzyme complex was studied to see what ingredients will provide your digestive system with the best possible support. Following is the ingredients of possibly the best digestive supplement you can get your hands on.
The first ingredient found in this complex is protease. This enzyme breaks down long protein chains at different levels of your stomach's pH level.
Amylase is another enzyme found in this complex. It breaks down large carbs like starches into disaccharides and glucose for your body's energy levels.
Lipase, another ingredient of the best digestive supplement, breaks down the fats you consume into fatty acids and glycerol. Cerecalase, another great ingredient, is a blend of enzymes which breaks down the cell wall bonds of nutrients such as phytate and hemicelluloses.
Glucoamylase breaks down maltose into glucose, malt diastase enhances the breakdown of starch and peptidase hydrolyzes protein molecules into amino acids.
More ingredients include bromelain - extracted from pineapple stems, papain extracted from papaya; another enzyme which helps to digest proteins and a last ingredient, cellulase, which breaks down the cellulose and glucose found in fiber. You might wonder whether these enzymes are being destroyed by your stomach juices, but most of the best digestive supplements' ingredients are processed in such a manner that they can withstand the extreme conditions in your stomach. This myth has been disproven countless of times, so it's not a waste of your money to invest in the best digestive supplements.
When you've taken the best digestive supplements, you can expect to have more energy and have better digestion and bowel movements. It is normal for some people to experience detoxification in the beginning stages of taking these supplements. This might feel uncomfortable but it is a good sign that your body is responding positively to the enzymes. Upping your enzyme intake and drinking a lot of water can help you through the beginning process.
When looking for the best digestive supplement, you should look at the enzyme activity rather than the ingredients. The most important thing is to look out for supplements that are acid stable and able to be active in a broad range of pH levels. Steer clear of any ingredients you might be allergic to, like papain or bromelain. Look for what experts call a broad range digestive supplement. The more enzymes it contains, the wider the range of nutrients it will make your body able to digest. When in doubt, speak to your doctor or pharmacist first. If you have specific digestive problems you should have that looked into before trying such a common remedy.
The Good and Bad of an iron supplement
April 25, 2010 06:04 PM
Iron holds a crucial role in the physiology of the body. It is a central part of the haemoglobin and myoglobin molecules. Iron is indispensable to the body’s ability to transport gases into and out of the cell. It is necessary in many important enzymes that are involved in energy production, metabolism, and DNA synthesis. Some iron is lost when red blood cells are broken down and excreted in the bile. However, because of iron’s importance, the body is able to conserve iron at all costs, as the kidneys do not eliminate the metal.
The dark side of iron supplementation comes when iron is consumed in amounts that are excessive to the body’s needs. Although unbound iron is more likely to cause oxidative challenges through the generation of free radicals, excessive iron supplementation in any form can cause huge problems for the cell. The overload of iron can cause deterioration of the gut lining, vomiting and diarrhea, abdominal and joint pain, liver damage, loss of weight, and intense fatigue. In children, acute doses as low as 3 grams can cause death.
About one out of every 250 North Americans suffer from haemochromatosis, which is a genetic defect that is common in a lot of those people of northern European descent. This disorder causes the body to accumulate and abnormally store high levels of iron. Those people with haemochromatosis store twice as much iron as others, which places them at increased risk for iron-related diseases. Symptoms of these diseases generally occur after fifty years of age and often include things ranging from fatigue, abdominal pain, achy joints, impotence, and symptoms that mimic diabetes.
Several studies have produced evidence which suggests that high levels of iron contribute to noticeable increases in the risk for cardiovascular disease. This is likely due to non-haeme iron’s aggressive pro-oxidant nature. Iron levels are one of the strongest biochemical markers for the progression of atherosclerosis, which results from increased oxidation of LDL cholesterol. A study in 1995 conducted on Finnish men found that those who had high body stores of iron also had a substantially increased risk of heart attack. Those men who posses the highest levels of stored iron often showed a levels of risk that was up to three times that of men who possessed the lowest levels of stored iron.
Disorders in iron accumulation contribute to a whole host of other disease states, all of which are degenerative in nature. Studies have shown that chronic iron overload contributes to increased infections, cancer, arthritis, osteoporosis, diabetes, and various congenitive dysfunctions. The only way to remove excess iron is through blood letting, unless you are a woman with regular menses. That is why, for men, iron overload can provide quite a problematic issue. Recent research has found that long-term supplementation with iron at doses less than 5 mg/day can lead to iron-overload toxicity. Because of this, it is recommended that the upper limit of iron intake be at 5 mg/day when considering a product’s rating. Any product that contains iron at a daily dose greater than this limit is penalized with this rating criterion.
But for those who need iron, it can easily be obtained through a vitamin supplement at your local or internet health food store. Men should avoid iron supplements and products containing iron, but women on the other hand due to monthly blood loss should supplement with iron regularly.
DHEA and Your Health
March 16, 2010 12:27 PM
DHEA is a naturally occurring hormone that is produced within the adrenal glands. The most abundant hormone found in the body, it is sometimes referred to as the “mother hormone.” When hormone levels are too low or out of sync, the body is unable to function as intended. DHEA levels reach their peak in the body around age twenty-one. After that, the levels tend to decline over the years. This substance is a precursor hormone that can be metabolized into other adrenal hormones and act with other hormones.
When DHEA levels are normal, it aids the immune system in maintaining balance and fighting diseases and infection. This, in turn, protects the body form a variety of serious problems that can occur, including cancer. Although the full extent of DHEA's benefits is not entirely known, there is a great deal of evidence that links low levels of DHEA to conditions such as cancer, Alzheimer's disease, arthritis, osteoporosis, chronic fatigue syndrome, diabetes, fertility problems, lupus, rheumatoid arthritis, multiple sclerosis, allergies, PMS, and even weight problems. Many people even believe that this hormone is the single most important factor in maintaining health.
Scientific studies have determined that individuals with cancer seem to have lower levels of DHEA than those individuals who are healthy. It has been found that DHEA has the ability to inhibit one of the most important enzymes that is responsible for the feeding of cancer cells. Research has also concluded that DHEA can help in a variety of types of cancer, including colon, lung, skin, breast, lymphatic, gastric, prostate, and ovarian. It is believed that DHEA aids in slowing the growth of cancer. This hormone also blocks some of the enzymes that are responsible for cancer proliferation, which helps to prevent the activity of cancer and stops damage from occurring.
Alzheimer's condition is extremely frightening, as it deals with the loss of memory and senility. It has been found that levels of DHEA in Alzheimer's patients are forty-eight percent lower than the normal, healthy level established by the control group. DHEA is responsible for protecting the brain cells from damage and deterioration. Also, it is useful with other degenerative conditions that deal with senility. In healthy individuals, DHEA can be found abundantly in brain tissue, which protects against aging and damage.
DHEA is a precursor for cortisol and adrenaline, both of which are stress hormones. DHEA can become depleted when the body is under stress due to the effect on the adrenal glands. Because of this, chronic stress can lead to lower levels of DHEA, which can be detrimental to one's health. It has been found the prolonged stress can lead to cases of depression, with depression being helped by the addition of DHEA. Individuals with depression have found favorable results when using DHEA.
It has been shown that DHEA therapy is free of side effects when taken in proper amounts. Some problems that occur when excess amounts of DHEA are supplemented include acne, rapid heartbeat, irritability, and headaches. The majority of people solve these problems by lowering the amount they are taking. For more information on the many beneficial effects provided by DHEA, please feel free to contact a representative from your local or internet health food store.
Dhea is a hormone naturally found in the body now available over the counter at your local health food store.
Vitamin B 6 - Two Stage Timed Release single supplement - NEW
August 07, 2006 12:29 PM
It’s About Time
Solaray has enhanced the value of single dose products through its Two-Stage, Timed-Release process, which is designed to release vitamins to the body over a long period of time.
How are the ingredients designed to release over an extended period?
The active ingredients (Vitamin B 6) are encapsulated in a small sphere, which helps to prevent the actives from being released until the sphere walls are broken down over a period of time in the digestive system. The time of release is dependent on the thichness of the sphere walls. This helps the ingredients (Vitamin B 6) to be slowly released over a period of time. These walls are very thin, allowing them to be broken down easily and also requiring as much as 30% - 50% of the formula to be the timed-release agents. Solaray two-stage, timed-release products are intended to provide a higher level of actives with a lower level of timed-release agents.
First Stage: Half of the active ingredients (Vitamin B 6) are intended to be released immediately.
Second Stage: The remaining active ingredients (Vitamin B 6) are intended to be gradually released over an extended period of time. The goal is to lead to more balanced and sustained levels of nutrients in the blood and ultimately, better cell utilization and overall benefit.
Available in 50mg 60ct, 100mg – 30ct, 60ct, and 120ct.
HEART RESPONSE - Comprehensive Support for a Healthy Heart!
June 02, 2005 11:51 AM
Today’s modern lifestyle, filled with stress, pollution, overprocessed and fatty foods, and lack of exercise, places great strains on the cardiovascular system. Source Naturals HEART RESPONSE is a broad-range formula that supports cardiovascular health, especially heart muscle contraction, healthy circulation and the generation of cellular energy.
HEART RESPONSE features clinical potencies of the renowned heart botanical, hawthorn, and significant amounts of the energy nutrients, coenzyme Q10 and carnitine, along with additional nutrients and herbs. Each daily use supplies 600 mg of hawthorn, the same amount used in recent research.
Supports Heart Health
HEART RESPONSE was formulated to include key nutrients and herbs known to support the cardiovascular system.
Hawthorn: Hawthorn, a rich source of flavonoids and procyanidins, has been used traditionally all over the world as a strengthening circulatory and heart tonic.
Modern research has documented that hawthorn increases coronary blood flow and strengthens the contraction of heart muscle. Hawthorn is also an antioxidant, which scavenges and neutralizes destructive free radicals. It is only when cholesterol is oxidized that it impacts the integrity of arteries.
Coenzyme Q10: HEART RESPONSE supplies 60 mg daily of CoQ10, a key enzyme in the Electron Transport Chain, the pathway that generates 90% of the ATP “energy currency” needed by the body. Heart muscle requires huge amounts of energy to perform efficiently—it beats more than 100,000 times each day, pumping more than 1,000 gallons of blood through the body. The heart utilizes ATP as an energy source for muscular contraction. CoQ10 also is a fat-soluble antioxidant.
L-Carnitine: Carnitine is an amino acid-derived substance that supports heart muscle metabolism. Carnitine is needed to carry long chain fatty acids into the cell mitochondria, where they undergo oxidation to generate energy. The heart utilizes fatty acids as a preferred energy source for its metabolism.
HEART RESPONSE delivers 300 mg per day of carntine. Taurine and Magnesium: Magnesium and taurine work closely together in the body to help maintain the normal electrical rhythm of the heart. Taurine comprises more than 50% of the free amino acid pool in our hearts, and has many electrophysiological effects on cardiac muscle cells. Alterations in magnesium levels can have profound effects on the heart. Magnesium is involved in autonomic control of the heart through several mechanisms. Bromelain: Bromelain is an enzyme mixture prepared from pineapple stems. Pineapple has been used for its health benefits for more than 500 years.
Grape Seed Extract: Grape seed is a source of procyanidins. These plant constituents are strong antioxidants that inhibit lipid peroxidation and scavenge free radicals. In vitro studies have demonstrated that procyanidins support the integrity of connective tissue. Garlic: The use of garlic for its health benefits predates written history. Garlic’s volatile oil includes sulfur-containing compounds such as allicin, which are considered to be important biological constituents.
Selenium: Selenium is an essential trace mineral that is necessary for the activity of the important antioxidant glutathione. Antioxidants are crucial for protecting cholesterol from oxidation, which in turn helps to maintain healthy blood vessels. B-Vitamins: Preventing an undesirable buildup of homocysteine levels may help support the integrity of arteries. Vitamins B-6, B-12 and folic acid are critical to the regulation of homocysteine levels.
You can count on Source Naturals’ expert formulators to bring you a product based on the most up-to-date nutritional research. HEART RESPONSE combines traditional botanicals and cutting-edge nutrients, scientifically formulated to deal with many aspects of cardiovascular health. It is available in bottles of 30, 60 and 90 tablets.
Spectro 3 and Spectro Multivitamin
May 21, 2005 10:20 AM
Comes in a large range of sizes.
Spectro Iron Free multivitamin 100ct
Spectro Iron Free Multivitamin 250ct
Spectro Iron Free Multivitamin 360ct
Spectro 3 multivitamin 180ct
Spectro 3 Multivitamin 90ct
Spectro 3 Iron Free multivitamin 180ct
Spectro 3 Iron Free multivitamin 90ct
Spectro Smoothie drink mix 720g
Spectro Vegetarian multivitamin 90ct
Spectro Vegetarian Multivitamin 180ct
Sytrinol -- Natures way to lowering cholesterol up to 40%
May 20, 2005 12:12 PM
In a Lab experiment, cholesterol was lowered by 40%
Formulations contg. citrus polymethoxylated flavones (PMF), mainly tangeretin, or citrus flavanone glucosides hesperidin and naringin were evaluated for blood cholesterol-lowering potential in hamsters with diet-induced hypercholesterolemia. PMF metabolites were also investigated. Diets contg. 1% PMF decreased blood serum total and very-low-d. lipoprotein (VLDL) + LDL cholesterol by 19-27 and 32-40%, resp., and decreased serum triacylglycerol levels. Comparable decreases were achieved by feeding 3% mixt. of hesperidin and naringin (1:1), implying lower hypolipidemic potency of the hesperidin/naringin mixt. vs. PMF. HPLC-MS anal. identified high blood serum, liver, and urine concns. of tangeretin metabolites, including dihydroxytrimethoxyflavone and monohydroxytetramethoxyflavone glucuronides and aglycons. The total liver concns. of tangeretin derivs. corresponded to hypolipidemic concns. of intact tangeretin in earlier expts. in vitro. PMF may be novel flavonoids with cholesterol- and triacylglycerol-lowering potential. Elevated liver levels of PMF metabolites may be directly responsible for their hypolipidemic effects in vivo.
Sytrinol 150mg 30ct
Sytrinol 150mg 60ct
Sytrinol 150mg - 60SoftGels
Cranberry (Vaccinium macrocarpon)
May 19, 2005 10:34 AM
VitaNet ® Staff
KudZu, Treatment of alcohol dependence or alcohol abuse
May 19, 2005 09:29 AM
For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.
Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.
While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.
Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:
CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH
In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:
CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH
Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).
Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.
Kudzu Recovery 60ct
Kudzu Recovery 120ct
Kudzu Root Extract 50caps
Kudzu Root Extract from Solaray 60ct
Acidophilus: Nature’s Antibiotic
May 18, 2005 05:51 PM
Acidophilus: Nature’s Antibiotic
Lactobacillus acidophilus has been found to contain antibiotic properties. According to Dr. Khem Shahani, a professor of food science at the Un i versity of Nebraska, milk fermented by Lactobacillus acidophilus contains an antibiotic he calls “acidophilin.” It is a powerful antibiotic with similar abilities as penicillin, streptomycin and terramycin. He actually believes that it is more powerful than the antibiotics mentioned.7 Detrimental bacteria invade our bodies on a daily basis. Supplementing with either yogurt containing live cultures or a freeze dried capsule may be necessary to protect the body. Lactobacillus acidophilus can protect the digestive system from microorganisms causing infection and disease. It is a supplement that can help protect the body and work as “nature’s antibiotic.”
Plain yogurt is basically a combination of milk and Lactobacillus acidophilus, the friendly bacteria. This is the bacteria that produces lactase which aids in the process of curdling the milk and giving yogurt its tart flavor. Yogurt containing live cultures of Lactobacillus acidophilus have been found effective in treating vaginal yeast infections, infant diarrhea, food poisoning,and in preventing flu infections.8 Yogurt must contain the live, active cultures of Lactobacillus acidophilus to be beneficial. The intestinal flora can be disrupted by conditions such as antibiotic therapy, stress, a poor diet, excess sugar consumption, and oral contraceptives. This friendly bacteria is not destroyed by the acidic gastric juices in the stomach and protects the body by adhering to the intestinal wall. Yogurt is a great way to add the beneficial bacteria often needed in the body. Some physicians recommend plain yogurt to patients undergoing antibiotic therapy to counteract the negative effects of the antibiotic. Many of the commercial brands of yogurt found in the neighborhood grocery store do not contain live, active cultures. Check carefully to assure the best quality available. Most health food stores have specialty brands with live cultures.
Acidophilus Probiotic 4 - 250ct
Acidophilus Probiotic 4 - 100ct
Acidophilus Probiotic 5 - 60ct
Immunomodulating and anti-tumor action of extracts of several mushrooms
May 18, 2005 10:11 AM
Quote from Abstract:
The outcomes obtained in the experiments in vitro have predetermined check of these extracts on antitumor effect in experiment in vivo.As a model of tumor growth, one of the most malignant tumors melanoma B16 was selected.
AHCC with proper diet and nutrition could help reduce tumor size and/or reverse cancer in humans as shown in lab animal examples.
AHCC Complex 30 ct from Source Naturals
AHCC Complex 60 ct from Source Naturals
AHCC Complex with Bioperine for absorption 60ct from Source Naturals
AHCC Complex with Bioperine for absorption 30ct from Source Naturals
AHCC Plus 30ct from Source Naturals
AHCC Plus 60ct from Source Naturals
Fenugreek and Cinnamon to lower blood sugar ...
May 18, 2005 09:27 AM
Fenugreek and cinnamon have had extensive studies devoted to their anti-diabetic properties. The major action of fenugreek may be via blockage of glucose absorption . Cinnamon has been shown to have insulin-like action  and affect insulin signalling . There is little association of diabetes treatment with cumin, pumpkin seed and oregano , although animal studies do suggest that cumin may lower circulating lipid levels in diabetic rats . The long-term safety of these condiments in the food supply suggests the possibility of daily use over the long haul to prevent or ameliorate insulin resistance and perhaps even increase useful lifespan [1,41]. Previous studies with other natural products have suggested this potential . Future studies are necessary to test the veracity of this hypothesis.
Control blood sugar and possibly increase or extend quality of Life and length of life.
Additional Supplements to lower Blood sugar.
May 18, 2005 09:24 AM
example, supplementary niacin-bound chromium [20,21], garlic , soluble fibres  and vanadium  can overcome, to some extent, many of these perturbations. Thus, natural nutrients/elements have the potential to favourably influence the glucose/insulin system and the onset of age-related chronic disorders with little threat of serious adverse side effects . We should mention that it is possible that proper combinations of these natural products may give even better risk/benefit ratios than single agents alone.
Gluco Science to lower Blood sugar 60ct
Gluco science to lower blood sugar 90ct
Gluco science to Lower Blood Sugar 180ct
VitaNet ® Staff
Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic
May 18, 2005 09:20 AM
Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.
Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension. Material and Methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.
Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula.
Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity. Keywords: diabetes mellitus, essential oils, insulin resistance, insulin sensitivity, insulin sensitivity, natural products Received 11 August 2003; returned for revision 25 September 2003; revised version accepted 16 March 2004 Introduction The prevalence of insulin resistance and its most severe form type 2 diabetes mellitus is rapidly increasing in the USA – even throughout the world [1–3]. The recent increase is attributed, at least to some extent, to the greater occurrence of overweight and obesity that is due mainly to an augmented intake of calories and refined carbohydrates, lesser consumption of fibres and a more sedentary lifestyle [4–6]. Obviously, reversal of these situations should ameliorate the problem. Unfortunately, more is often needed than simply advising lifestyle changes that frequently fail in order to combat insulin resistance and its accompanying perturbations (cardiovascular diseases, obesity, dyslipidemias, diabetes mellitus and premature ageing) [7,8]. Experience shows that the afflicted not infrequently require aids to help with the maintenance of a healthful lifestyle. Correspondence: Harry G. Preuss, D, Georgetown University Medical Center, Department of Physiology and Biophysics, Basic Science Building, Room 231B, 4000 Reservoir Road, N.W., Washington, DC 20057, USA. O R I G I N A L ART I C L E doi: 10.1111/j.1463–1326.2004.00386.x # 2004 Blackwell Publishing Ltd Diabetes, Obesity and Metabolism, 7, 2005, 193–199 193
Cinnamon Extract and Blood sugar 60ct
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Policosanol and cholesterol control ...
May 17, 2005 06:25 PM
In addition, after 30 days of therapy, 20 and 40 mg/day policosanol significantly ( P < 0.01) reduced low-density lipoprotein– cholesterol (15.9 and 17.0%, respectively) and total cholesterol (12.4 and 12.3%, respectively; P < 0.05), yet increased high-density lipoprotein–cholesterol values by 5% in both groups ( P < 0.05).
Policosanol is a mixture of higher aliphatic primary alcohols purified from sugar cane ( Saccharum officinarum L) 4,5 wax, the main component of which is octacosanol, followed by triacontanol and hexacosanol; other alcohols (tetracosanol, heptacosanol, nonacosanol, dotriacontanol and tetratriacontanol) are minor components. The cholesterol-lowering effects of policosanol have been proven in healthy volunteers, 6,7 patients with type II hypercholesterolaemia 8–25 and in dyslipidaemia due to type II diabetes mellitus. 26,27
The hypocholesterolaemic effect of policosanol is associated with inhibition of cholesterol biosynthesis at a step located between acetate consumption and mevalonate production, although inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase has been discarded. 28–30 Policosanol also increases low-density lipoprotein (LDL) receptor-dependent processing in fibroblast cultures, 28 as well as the clearance of [ 125 I]-labelled LDL–cholesterol (LDL-C) administered to rabbits with hypercholesterolaemia induced by a cholesterol-free casein-rich diet. 29
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Policosanol 10mg 30tb from Source Naturals
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Policosanol 10mg with CoQ10 60ct from Source Naturals
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Increase Energy and Adapt to stress with Kudzu...
May 17, 2005 04:10 PM
Planetary Formulas This product features the roots and flowers of kudzu (Pueraria lobata), which have long been used in Chinese herbalism to help lessen the desire for alcohol. These are combined with coptis, a primary cleansing and liver-supporting herb from Chinese herbalism, and other key botanicals to support balanced blood sugar levels and enhance energy levels. Kudzu may help restore adrenal glands.
Kudzu Recovery 60ct
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Try some other brands
Kudzu Root Extract 50caps
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Composition and Method of increasing Testonsterone...
May 17, 2005 04:01 PM
Composition and method for increasing testosterone levels
Abstract This invention provides compositions and methods related to the administration of deer antler, one or more nor-testosterone precursors, and one or more testosterone precursors, to increase testosterone levels, treat sexual dysfunction, improve sexual function, improve energy, enhance feelings of well-being and increase muscle mass in males. This invention also provides for inhibitors of the enzymes aromatase and/or 5-alpha reductase, to support testosterone levels and avoid undesirable metabolites.
May reduce DHT:
By using velvet deer antler along with the testosterone and nor-testosterone precursors, the antler promotes youth film testosterone levels while balancing and ameliorating dangerous spikes in these levels. Another embodiment of the invention includes herbs that inhibits 5-alpha-reductase reducing undesirable levels of dihyrotestosterone. Another embodiment includes chrysin, which inhibits aromatase and the production of estrogenic steroids.
Deer antler (called Rokujo in Ancient Chinese Medicine) is used for its sexual-reinforcing and anti-aging actions. Wang et al., 36(7) CHEM. PHARM. BULL. 2587-92 (1988). Velvet antler is living tissue that grows at a rate of up to 2 cm/day in some species. Cartilage, bone and support tissues such as nerves, blood vessels and hair follicles of the antler also evidence accelerated growth. Antler is the only mammalian organ that regenerates. These features, responsible for the accelerate growth of velvet antler are likely to be caused by either unique regulatory substances or substances found in other tissues but at lower levels. It is believed that factors actually responsible for the rapid regeneration of the velvet antler can explain the powerful health benefits of the product. Specifically, velvet deer antler regulates the adrenal cortex and energy metabolism, promotes sexual function and growth, and strengthens resistance. Its functions fall into the major categories of general body strengthening, healing, promoting blood cell growth and improving immune and cardiovascular function.
Some of velvet deer antler's key ingredients include lysophosphatidyl choline, with hypotensive activity, phosphatidyl ethanolamines, sphingomyelin, phosphatidyl choline hypothanthene and uridene, with monoamine oxidase (MAO)-inhibiting and anti-aging effects; polyamines spermine, spermidine and putrescine, with RNA polymerase stimulating effects; gangliosides that may promote memory and learning; and anti-inflammatory amino acids. A wide variety of growth factors are also found in velvet, and may be associated with its growth-promoting activity. Tsujibo et al., 35(2) CHEM. PHARM. BULL. 654-59 (1987).
As taught by ancient Chinese medicine, deer antler tonifies the yang, primarily deficient yang of the kidneys, spleen and heart. Because kidneys are the seat of the basal yang, the most important use of this class of herbs is to tonify the kidney yang, whose principal manifestation of deficiency is systemic exhaustion. Yang deficiency causes impotence, spermatorrhea, watery vaginal discharge, infertility, enuresis, polyuria, wheezing and daybreak diarrhea. Patients with deficient kidney yang very often have decreased plasma thyroid hormone binding proteins, 24-hour urinary 17-ketosteroids, and decreased rate of glycolysis. When treated with tonifiers such as deer antler, these measurements return to normal ranges. BENSKY ET AL., CHINESE HERBAL MEDICINE, MATERIA MEDICA, REVISED EDITION Eastland Press, Seattle, Wash. (1993).
Deer Antler Velvet Full Spectrum Planetary Formulas 30Ct
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Block the Absorption of Carbs in the intestinal track.
May 17, 2005 02:39 PM
Carb-X™ dietary supplement features 600 mg white kidney bean extract, along with 200 mg wheat inhibitor extract, per two capsules. Both extracts have been studied for their potential ability to support the inhibition of amylase, the enzyme created by the body to break down sugars and carbohydrates. Amylase inhibitors bind and inactivate this enzyme so carbohydrates and sugars pass through without breaknig down. Carb-X ™ dietary supplement formula is a new revolutoinary aid to dieting. When combined with the NaturalMax® Diet Plan, it can help decrease calories from carbohydrates.
Carb X from Natural max 90ct
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Carb X Shake mix Chocolate
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Help stop Migraines with Feverfew and other herbs.
May 17, 2005 11:52 AM
A key component in Migra defense formulas is Feverfew extract. FeverFew extract has been shown in human cell culture studies to inhibit the synthesis of prostaglandins known to cause physical discomfort. Prolonged use of Feverfew shows promising results to help lower migraine intensity. Consistant use is required daily to see results.
MigraDefense from Kal
MigraGard 30ct from Solaray
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MigraActin - Migra Actin 60ct from Natures Plus
May 13, 2005 06:50 PM
Acute administration of red yeast rice depletes tissue CoQ10
May 13, 2005 03:00 PM
Basically, if you are taking a Cholesterol lowering product that works on the same order as prescription drugs, you need to supplement CoQ10 to replace what the body is removing.
British Journal of Nutrition (2005), 93, 131–135 DOI: 10.1079/BJN20041285 q The Authors 2004
Acute administration of red yeast rice (Monascus purpureus) depletes tissue coenzyme Q10 levels in ICR mice
VitaNet ® staff
Important Information for Allergy Sufferers
May 13, 2005 09:52 AM
Important Information for Allergy SufferersRichard Conant, L.Ac. C.N.
Imagine you are one among millions who greet each spring with worry about the flood of pollen that fills the air this time of year. When the pollen season arrives, as it inevitably does, you find yourself with two choices. You can either take over-the-counter antihistamines and put up with unpleasant side-effects, or endure the sneezing, runny nose, itchy, watery eyes and other discomforts of hay fever.
If there was a natural ingredient, a nutritional substance found throughout nature in many foods and plants, that could offer an alternative, would you not be interested?
Quercetin, one among hundreds of flavonoids found throughout the plant kingdom, is this ingredient. Quercetin has been researched in numerous pharmacological studies. The results of this work strongly suggest that quercetin helps to stabilize the fundamental process in the body which causes an allergic reaction. Quercetin, as shown in test-tube ("in vitro") studies, prevents the release of histamine from "mast cells," immune cells that stand guard in the tissues which meet the outside environment—the nasal passages, the lungs, the digestive tract and skin. While this has yet to be confirmed by human clinical trials, in the picture that emerges from the research so far, quercetin looks like a rescue nutrient for allergy sufferers.
Reports from Quercetin Users
I have seen numerous reports from individuals who have indeed achieved significant reductions in allergic sensitivity by using quercetin. And this includes food allergies as well as environmental allergies. Anecdotal stories like these carry little weight among scientists, because they do not provide evidence that the observed result will be repeated in other cases. Only placebo-controlled, double-blind studies can produce this kind of scientific proof. Yet, when anectodal evidence (this includes physician "case reports") correlates with the results of pharmacological research such as we have on quercetin, I believe it should be taken seriously. And quercetin is a nutrient that works effectively when taken as a dietary supplement.
For example, one gentleman writes that his wife, who is allergic to pollen and dust, is now "sneeze-free" after using quercetin for three years. A Pennsylvania woman writes that her husband, also a long time allergy sufferer, "seems to be nearly allergy free" after one month of use. Another man says that "quercetin has literally changed my life." These are not isolated cases; a respected nutritionist who specializes in allergies and environmental problems has seen many similar outcomes with a quercetin. Clearly something significant is going on with respect to quercetin as a nutritional approach for overcoming allergies.
Bear in mind, though, that quercetin does not function like an antihistamine medication; it is not a quick fix. As a nutrient that helps to normalize body functions naturally, quercetin needs time to work, and should be taken for at least two or three weeks to achieve these results.
Quercetin Quiets the Allergic Response
Exerting a broad range of biological effects, quercetin is perhaps the most active and versatile flavonoid. In test-tube studies, quercetin acts directly on the mast cell in a way that quiets the allergic response.
An allergic reaction occurs when IgE antibodies, positioned on the mast cell surface, come in contact with a potential allergy-causing substance like pollen. The mast cell is then signaled to release histamine from storage granules located inside the cell, through a process called "degranulation." The histamine circulates throughout the body, causing the runny nose, itching and other discomforts associated with allergies.
Quercetin stabilizes mast cell membranes, in effect turning down the allergic response signal. Quercetin also slows other mechanisms which are involved with inflammation, such as the production of inflammatory prostaglandins and leukotrienes. This adds to its membrane-stabilizing effect, and its value in allergy control.
Quercetin appears to substantially raise the threshold for initiation of an allergic reaction. In allergy sufferers this threshold is low, for reasons which are not well understood. They may have more IgE antibodies than normal, making the mast cells overly "trigger happy." Histamine has its proper place in the immune response that defends us against truly harmful foreign substances in the body. But like many chemicals produced by the body, histamine is a two-edged sword. In allergy-prone individuals, the mast cells have become overreactive, releasing too much histamine, unnecessarily. With quercetin in the bloodstream, histamine release from mast cells is kept under control. Quercetin's ability to down-regulate both the inflammatory and allergic responses makes it, I believe, a highly important nutrient for humans to consume on a regular basis.
Quercetin-the Scientific Evidence
Several studies, published in respected journals such as the Journal of Allergy and Clinical Immunology and others, have demonstrated quercetin's ability to control the release of histamine from mast cells. (Quercetin has the same effect on basophils, a type of white blood cell that also contains histamine.) In these experiments, mast cells taken from both animals and humans are exposed in the test tube to various substances—called "antigens"— that stimulate histamine release. The researchers then add an inhibiting agent such as quercetin to the mixture and measure the differences in histamine output. Quercetin has shown itself to be one of the more powerful histamine inhibitors, more powerful, in fact, than disodium cromoglycate, an anti-asthma drug.
Quercetin has other beneficial properties. A strong antioxidant, Quercetin has a higher level of antioxidant activity than both vitamin C and vitamin E. (Quercetin enhances the antioxidant activity of vitamin C; quercetin and vitamin C are true synergists.) Quercetin has been shown to block the oxidation of LDL cholesterol by free radicals. Quercetin also protects cell membranes from being injured by oxidized LDL. The damage that oxidized LDL causes to the delicate membranes of blood vessel linings allows plaque deposits to form, setting the stage for atheroslcerosis. These observations point to quercetin as a key nutrient for maintaining cardiovascular health.
Like all flavonoids, quercetin is not classified as an essential nutrient, although flavonoids were once called "Vitamin P." In view of its many beneficial actions, quercetin is a nutrient that clearly has important roles to play in human nutrition, for allergy sufferers, and for everyone.
May 12, 2005 05:14 PM
VitaNet ® Staff
May 12, 2005 01:08 PM
Guggul – New Benefits for Heart Health
May 11, 2005 09:00 PM
Gum Guggul–New Benefits for Heart Health from an Age-Old Herbby Richard Conant, L.Ac., C.N.
The 1990's have seen a growing interest in herbs from India's ancient Ayurvedic tradition. One Ayurvedic herb in particular, "gum guggul," stands at the forefront, thanks to its rather remarkable benefits for the heart and cardiovascular health. A relative of myrrh and frankincense, gum guggul is a resin tapped from India's Commiphora mukul tree. Known more commonly in the Far East as simply "guggul," the herb has proven to be one of the most effective natural cholesterol-lowering agents ever discovered. Cholesterol reductions with guggul can be twenty percent or higher, and the herb also raises HDL, the more beneficial form of cholesterol. Studies also show guggul may help prevent atherosclerosis, by retarding the formation of fatty, cholesterol-laden deposits in blood vessel tissues.
Recent research on guggul has revealed that guggul also blocks the oxidation of LDL cholesterol, by acting as an antioxidant. LDL, which carries cholesterol from the liver to the rest of the body, is generally regarded as a key element in the development of atherosclerosis. But only when it is oxidized by free radicals does LDL accumulate in arteries. It its unoxidized or "native" state, LDL is more or less benign. Checking LDL oxidation is vital to keeping blood vessels free of plaque.1 (This is one of the major reasons why antioxidants are so important.) Guggul, by both lowering blood cholesterol and acting against LDL oxidation, now stands out as one of the world's most valuable herbs for heart health.
Guggul first caught the attention of the scientific world in1966, thanks to an Indian medical researcher who submitted a doctoral thesis on gum guggul.2 Her interest had been kindled by references to the herb in a centuries-old Ayurvedic text. Apparently, poor cardiovascular health and atherosclerosis were a problem back then just as they are today. Translated from Sanskrit, this text describes, in elegant detail, a condition called "coating and obstruction of channels." The cause, according to the ancient writers? Faulty metabolism due to overeating of fatty foods and lack of exercise. Death was said to be the end result of leaving this condition uncorrected. The recommended treatment plan emphasized diet and herbs, chiefly gum guggul.3
References to guggul in ancient literature actually go back even farther. The herb is mentioned in the Vedas, the holy scriptures of India believed to be anywhere from 3,000 to 10,000 years old. One stanza is translated as follows: "Disease (consumption) does not afflict and the curse never affects whom the delicious odor of the healing Guggul penetrates (spreads). The diseases also flee away in all directions from him like horses and deer, O Gugulu! Either born from Sindhu or from the sea. I chant your name for the removal of diseases."3
Struck by the obvious similarity between "coating and obstruction of channels" and atherosclerosis, the Indian researcher decided to study gum guggul's effect on blood fats in rabbits. Over a two-year period, the animals were fed hydrogenated vegetable oil to artificially raise their cholesterol levels. Guggul was administered to one group of rabbits, while the rest served as controls. At the end of the study the rabbits given guggul had normal cholesterol and blood lipid levels. Their arteries showed no fatty streaks or plague deposits. This caught the attention of the Indian scientific community, and numerous clinical trials ensued, both on animals and humans. In study after study, guggul consistently produced substantial reductions in cholesterol and triglyceride levels, while raising HDL.
The active ingredients in guggul are a group of natural plant sterols. Among these, substances called "guggulsterones" are the most important ingredients for the cholesterol and blood fat lowering properties of guggul, with the other sterols acting as a synergistic supporting cast.4 A number of mechanisms are suggested, although not definitely proven, for how the herb works; these include reducing the synthesis of cholesterol in the liver, enhancing cholesterol removal from the gut, stimulating thyroid function and increasing the number of receptors in the liver for uptake of LDL.3,5
Guggul extracts are now standardized for guggulsterone content. The herb naturally contains about 2 percent guggulsterones. Quality extracts contain a minimum of 2.5 percent, which assures the user is getting a product potent enough to produce results. Since the late 1980's clinical trials have used the standardized extract.6,7,8 The product is readily available in the U.S.
The ability of guggulsterones to prevent oxidation of LDL was discovered in a 1997 study done by scientists at the Central Drug Research Institute in Lucknow, India.9 This study sheds light on how guggul works against "coating and obstruction of channels." Remember that oxidized LDL forms the plaque that coats and eventually obstructs blood vessels. The researchers mixed LDL from human blood with a free radical promoting agent, either alone or in combination with guggulsterones. Samples were then analyzed for the presence LDL oxidation byproducts. The results showed that guggulsterones strongly protect LDL from being oxidized. Guggulsterones block the formation of hydroxyl radicals, a potent type of free-radical that attacks cell membranes.
Guggulsterones may also help keep the heart muscle itself healthy. When the heart muscle is deprived of oxygen, a condition known as "myocardial ischemia," it can be severely damaged by free radicals. The body tries to counter this with SOD, a key enzyme present in cells that neutralizes free radicals. SOD levels are significantly reduced in damaged heart tissues. Guggulsterones have been found to reverse this decrease by more than two-fold.10
Like the writer of that age-old verse found in the Vedas, contemporary herbalists hold gum guggul in the highest regard. Backed as it is by scientific research linked to centuries of traditional use, gum guggul has a bright future as a natural resource for maintaining normal cholesterol and blood fats, and for protecting heart health.
1. Heinecke, J.W. Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radical Biology & Medicine 1987;3:65-73.
2. Satyavati, G.V. Effect of an indigenous drug on disorders of lipid metabolism with special reference to atherosclerosis and obesity (Medoroga) M.D. thesis (Doctor of Ayurvedic Medicine). Banaras Hindu University, varanasi, 1966.
3. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.
4. Dev, S. A modern look at an age-old Ayurvedic drug-guggulu. Science Age July 1987:13-18.
5. Singh, V. et. al. Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. Pharmacological Research 1990;22(1):37-44.
6. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.
7. Agarwal, R.C. et. al. Clinical trial of gugulipid-a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.
8. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.
9. Singh, K., Chandler, R. Kapoor, N.K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytotherapy Research 1997;11:291-94.
10. Kaul, S. Kapoor, N.K. Reversal of chnages of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. Indian Journal of Experimental Biology 1989;27:625-627.
Phosphatidylserine––A Nutrient for Mental Fitness...
May 11, 2005 10:26 AM
Phosphatidylserine––A Nutrient for Mental Fitness, an Anti-aging Nutrient for the Brainby Richard Conant, L.Ac., C.N.
As baby boomers age and the senior population swells, more and more people are faced with the impact of aging on the brain. Loss of memory and thinking ability ranks high among aging's most debilitating consequences. Gradual memory loss in people over fifty, when not caused by a specific neurological disease or other medical problem, is defined as "age associated mental impairment" or "AAMI."1
Nutritional Support for Prostate Health
May 11, 2005 10:19 AM
Nutritional Support for Prostate HealthBy Steve Lankford
Prostate problems are perhaps the most common problem that men will experience. As men age their hormonal production and metabolism changes and these changes can contribute to the prostate difficulties that men experience. The two major prostate problems are enlargement of the prostate gland known as benign prostatic hyperplasia (BPH) and prostate cancer. These two problems are unrelated except that they both affect the prostate gland and the scope of this article will focus on BPH.
The prostate gland is a small gland located under the bladder. It is shaped like a donut and surrounds the neck of the bladder and a small portion of the urethra. The urethra is the tube that carries the urine out of the body. When the prostate gland enlarges it can constrict the urethra and the flow of urine. This contributes to the variety of symptoms of BPH. BPH affects over half of all men aged 50 and older.
Benign Prostatic Hyperplasia
BPH is related to the hormonal changes that men undergo as they age. Around age 40 men begin to produce more of the enzyme 5-alpha-reductase. 5-alpha-reductase converts the hormone testosterone into the less desirable hormone called dihydrotestosterone (DHT). DHT is an important hormone and is not a problem until the levels begins to increase around mid-life. The increase in DHT results in BPH.
The symptoms of BPH include hypersensitivity of the bladder to even small amount of urine. This results in an increase of both urgency and frequency. Men will often experience frequent nighttime urination. The urine stream may become weaker and include dribbling when men are unable to completely void the bladder. Serious BPH can cause a complete blockage of urine flow.
Three stages of support
There are three stages at which you may want or need to deal with BPH. The first stage is preventive. At this stage there are no symptoms and one may do something at this stage when trying to provide benefit and support to avoid or minimize future involvement. The ideal time to begin preventive support is between the ages of 40 and 50.
The second stage is when there are emerging symptoms. This is when men first begin to experience the symptoms of BPH. The symptoms are mild and no too difficult to tolerate. This is also the best time to reverse the trend and provide effective nutritional therapy.
The third stage is when the symptoms have progressed to the difficult and serious level. It often progresses to this point when men ignore the symptoms and treatments. Often men have tried traditional medical approaches with little satisfaction or results. Even at this stage of BPH, nutritional support is usually very effective.
The challenge of creating an effective prostate support program begins with an assessment of your current status and then making an informed choice of support options.
The most successful natural approach to prostate health should involve a multiple approach that addresses the various systems in the body related to prostate health. The various nutrients that may be use can be taken separately or in combination. This approach can be beneficial both as a preventative approach as well therapeutic. You will generally have better results when you use a comprehensive approach.
The Comprehensive Approach to BPH
Prostate Support – Studies have show that dietary factors influence the overall health of the prostate. There are some nutrients that are found in higher amounts in the prostate. Nutrients such as zinc, lycopene and vitamin E provide prostate support.
Hormonal Regulation – Hormones have a direct role in prostate function. Plant extracts inhibit testosterone uptake by the prostate as well as limiting its conversion into DHT and subsequent binding to receptor sites within the prostate. Herbs such as saw palmetto, pygeum, nettle, red clover and soy provide this benefit.
Cellular Regeneration – Certain nutrients such as Swedish Flower Pollen, Quercetin and lycopene have demonstrated significant effects in maintaining proper prostate cell regeneration.
Bladder and Urinary Tract Health – The integrity and health of the bladder and urinary tract supports the normal flow of urine and prostate function. Three amino acids alanine, glutamic acid, and glycine as well as the herbs goldenseal, marshmallow root, uva ursi and pumpkin seed are all beneficial to the health of the urinary tract.
Soothing mechanisms – Certain plant compounds such as sterols and Swedish flower pollen as well as saw palmetto and pygeum and the bioflavonoid quercetin inhibit the metabolism of arachidonic acid. This influences prostaglandin synthesis, which is associated with prostate comfort.
Antioxidant Defense - The final area that we look at is how to reduce oxidative stress (free radical damage) that can trigger a host of destructive processes. Antioxidants play an important role in prostate function including protection of cell membranes.
Natural Is Better
How good are natural alternatives for prostate health? There have been many studies on natural alternatives showing that the proper herbs in the proper form are at least as effective as prescription drugs with fewer side effects. The most common drug for BPH is Proscar (finasteride). Some of the adverse side effects associated with finasteride are decreased libido and erectile dysfunction. Natural saw palmetto extract is free of these unwanted effects and is equally effective.
Choosing an Effective Product
The effectiveness of a nutritional product has to do with several factors. The bottom line is that the most effective product is the one that works best for you. Be prepared to try several products to find the best potency and combination.
There are many nutrients that provide prostate support. Vitamins, Minerals, Herbs, Amino Acids and Nutraceuticals are all helpful and the most comprehensive products will provide supports in multiple ways.
Vitamins – Vitamin D, Vitamin E
Minerals – Zinc, Selenium, Copper
Herbs – Saw Palmetto, Nettle Root, Marshmallow Root, Pygeum Bark, Pumpkin Seed Oil, Red Clover, Goldenseal Root, Gravel Root, Green Tea
Amino Acids – Alanine, Glutamic Acid, Glycine
Nutraceuticals – Soy Isoflavones, Quercetin, Swedish Flower Pollen, Phytosterols, Lycopene
The first nutrient and herb to consider is saw palmetto extract. It is the phytosterols in saw palmetto (and other herbs) that are responsible for the beneficial results. It is important to make sure that the product that you use has the therapeutically effective dose. If you don’t know the proper dosage and how to calculate the proper concentration it is very easy to purchase a low potency formula that is less likely to be effective.
In the clinical studies with saw palmetto extract, potencies of 320 mg. per day were used. However this only tell part of the story. The saw palmetto extract was composed of 85-95% sterols resulting in approximately 288 mg. (320 mg. times 90% equals 288 mg.) of sterols daily. Make sure your saw palmetto contains the correct amount of sterols.
This process of analyzing herbal extracts will apply to any standardized herbal product. You want to know whether the product you are purchasing has the right amount of the right compounds.
Search for the best products by trying different formulas. The proper nutrients taken consistently over time will provide long-lasting benefits. Stick with good companies with a history of providing quality nutritional products.
The information provided is nutritional only and is intended to help you develop a nutritional program that can support the functions of the body. The information provided is not intended as medical advice. For medical advice always consult your physician.
Long Jack PowerMax 200 from Action Labs
May 10, 2005 04:43 PM
Hot from the Jungles of Asia
Long Jack PowerMax 200
The newest Performance product from Action Labs brand, Long Jack is a plant native to southeast Asia that has two folk names -- One is TongKat Ali, which means Ali's walking stick, and the other is Long Jack (Eurycoma Longifolia jack).
May 09, 2005 11:35 AM
Source Naturals® Phosphatidyl Serine Retains High Potency
May 09, 2005 09:54 AM
Source Naturals® Phosphatidyl Serine Retains High Potency
Formulation Guarantees Most Shelf Stable Product in Soft Gels
Scotts Valley, California - November 5, 2003 - Source Naturals, creators of the highly acclaimed line of health and wellness supplements, is touting its improved form of Phosphatidyl Serine (PS) soft gels as the most shelf-stable PS available. The activity of PS was investigated by the makers of Leci-PS®, and two critical aspects were identified which influence the concentration of PS in soft gels. First, an enzyme used in the manufacture of PS must be eliminated prior to encapsulation, because this enzyme reacts with glycerol (in the gelatin), causing a degradation of PS. Second, it was found that moisture from the gelatin shell must be blocked from migrating into the capsule fill, because the presence of water in the PS fluid will cause a further loss of content.
The new, patent-pending Leci-PS® 20V blend, introduced in Source Naturals Phosphatidyl Serine Complex soft gels, contains an advanced PS formulation, 100% free of residual enzyme activity, which continually inhibits moisture migration. While nearly all other PS soft gels lose potency while sitting on the shelf, Source Naturals' new Leci-PS® soft gels remain stable.
PS is best known for its ability to reverse the effects of age-related cognitive decline and loss of memory, as well as playing a vital role in other brain functions. Phosphatidyl serine has also been shown to reduce stress and depression. PS is found naturally in soy beans, green leafy vegetables, rice and certain meat products. However, consuming an effective amount of PS simply through food is difficult, because the typical American diet includes many refined and processed foods, resulting in a loss of PS content.
"The natural PS content in soybeans is quite low. Approximately 3 kg of soybeans would have to be consumed to attain 100 mg of PS," said Stephen Sturm, Senior Project Manager in Product Development at Source Naturals. "We recommend supplementing the diet with 100 to 300 mg of our pure PS per day. This supplementation is especially beneficial for vegetarians, people on low-fat or low-cholesterol diets, and the elderly."
Source Naturals' PS is derived strictly from plant sources, and manufactured by the company that pioneered the use of plant-based PS. Numerous animal studies and human clinical trials have proven that soy-derived PS is just as efficacious as bovine-derived PS for mental decline. A clinical trial by Crook (1998) showed that three months of supplementation has effects on memory and cognition that are comparable to those of bovine-derived PS, with results even slightly favoring the soy-derived Leci-PS®.