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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell Cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell Cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative Cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell Cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) Cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway reCycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine Cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation Cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation Cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation Cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation Cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be reCycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Unlocking Your Cellular Vitality: Understanding the Role of Mitochondria in Energy and Aging
Date:
September 09, 2026 05:22 PM
Introduction: Understanding Cellular Aging and Energy DeclineHave you ever wondered why you could bounce back from an all-nighter or an intense workout in your twenties, but in your forties or fifties, the same physical effort leaves you feeling drained for days?Most people think aging is something that happens strictly on the outside - fine lines around the eyes, stiff joints, or gray hairs. In reality, aging begins at a microscopic scale inside your cells, the microscopic building blocks that make up every tissue, muscle, and organ in your body. Every single day, your body relies on roughly 30 trillion cells working in unison. When your cells are young and resilient, they operate like a well-oiled machine: they repair minor damage instantly, clear away waste, and produce abundant energy. But over time, two fundamental biological shifts take place:
The Role of Mitochondria and ATP ProductionTo understand where your daily energy comes from, you have to look inside your cells at tiny structures called mitochondria.Often called the "powerhouses" of the cell, mitochondria function like miniature power stations. A single cell can house hundreds or even thousands of them, especially energy-hungry cells like those in your heart, brain, and skeletal muscles. The Body’s Energy Currency: What is ATP?Your body cannot directly use a sandwich or a cup of coffee to power muscle contractions or brain signals. Instead, your mitochondria take the nutrients from your food and combine them with the oxygen you breathe to manufacture a chemical molecule called adenosine triphosphate (ATP).Think of ATP as your body’s universal energy currency:
Why Cellular Energy Production Declines with AgeWhen you are young, your mitochondria are abundant, pristine, and remarkably efficient. However, the very process of creating energy comes with an unavoidable side effect: oxidative stress.Much like an engine produces exhaust fumes while burning fuel, mitochondria produce reactive byproducts known as free radicals (reactive oxygen species). Over decades, these "exhaust fumes" slowly damage the inner machinery of the mitochondria:
How Cellular Senescence Accelerates the Aging ProcessIf mitochondrial decline is a problem of power shortage, cellular senescence is a problem of biological clutter and pollution.In a healthy body, normal cells follow a strict lifeCycle: they divide, perform their jobs, and when they incur significant damage or reach the end of their useful lifespan, they undergo a tidy self-destruction process called apoptosis (programmed cell death). Your immune system then clears away the debris, making room for fresh, vibrant cells. Cellular senescence happens when this cleanup process fails. The "Zombie Cell" PhenomenonWhen a cell experiences extreme stress - such as shortened telomeres (the protective caps on chromosomes), severe DNA breaks, or severe mitochondrial dysfunction - it reaches a biological crossroads. To prevent the damaged cell from dividing uncontrollably (which could lead to tumors), the body puts the brakes on.The cell enters a permanent state of dormancy:
Why Zombie Cells Are So Damaging: The Bad Apple EffectHaving a few retired cells hanging around might not sound catastrophic, but senescent cells do not sit quietly. Instead, they secrete a toxic chemical cocktail known as the Senescence-Associated Secretory Phenotype (SASP).This cocktail is packed with pro-inflammatory cytokines, chemokines, and tissue-degrading enzymes. Picture one spoiled apple sitting in a fruit basket: the ethylene gas it emits quickly causes the healthy apples surrounding it to rot. In the same way, the toxic secretions from zombie cells:
The Vicious Cycle of Cellular AgingMitochondrial decay and cellular senescence are not isolated events; they feed directly into one another:
What This Means for Everyday HealthThe good news from modern longevity science is that cellular decline is not entirely out of our hands. While aging is natural, the rate at which our cellular engines degrade can be influenced by daily habits:
Summary: Aging is fundamentally a microscopic process occurring inside the body's trillions of cells, which naturally become less resilient over time. Central to this decline are the mitochondria, the tiny structures that function as the cell's "power plants" to produce adenosine triphosphate (ATP), the universal chemical currency for everyday energy. While young mitochondria are abundant and pristine, decades of producing ATP generate oxidative stress through byproducts called free radicals, which eventually wear down and damage mitochondrial DNA and machinery. This damage results in fewer, less efficient power generators, lowering total cellular energy output, which individuals experience as real-world physical fatigue and mental fog. Aging is further accelerated by cellular senescence, a condition where damaged cells stop dividing but, instead of naturally self-destructing like healthy ones, linger behind as dormant "zombie cells." These senescent cells secrete a pro-inflammatory chemical mixture known as the Senescence-Associated Secretory Phenotype (SASP), which functions like a "bad apple" by poisoning healthy neighboring cells and tissues, creating a state of chronic biological pollution termed "inflammaging." Mitochondrial decay and senescence feed into one another in a vicious Cycle that directly drives overall aging. However, longevity science highlights that healthy lifestyle habits, including regular exercise and periods of fasting, can support continued vitality by encouraging the development of new mitochondria and the clearing of this toxic cellular clutter.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6649) Why the Ratio Matters: A Guide to Solaray’s New 40:1 Myo + D-Chiro Inositol Formula
Date:
August 26, 2026 02:21 PM
The formula centers on the clinically researched 40:1 ratio of Myo-Inositol to D-Chiro Inositol, precisely mirroring the natural balance found in healthy human blood plasma. A full daily serving of four vegetarian capsules provides 2,000 mg of Myo-Inositol alongside 50 mg of D-Chiro Inositol (totaling 2,050 mg). This specific ratio delivers the metabolic advantages of D-chiro inositol without overloading ovarian tissue, ensuring optimal intracellular signaling and insulin response. Solaray manufactures this supplement in an NSF-certified GMP facility in Utah, maintaining strict quality controls and clean-label standards. The capsules are 100% vegan, gluten-free, and formulated without unnecessary fillers. Every production lot undergoes rigorous laboratory verification—testing for identity, potency, microbials, heavy metals, and environmental contaminants to ensure high purity and consistency. Key Benefits:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6648) Clean Your Colon with Now Foods - 7 Day Colon Cleanse Formula!
Date:
August 26, 2026 12:03 PM
The primary health benefits stem from a balanced blend of synergistic ingredients. Psyllium husk (500 mg) provides essential soluble fiber that absorbs water, expands in the intestinal lumen, and binds waste material to facilitate smooth transit. To stimulate colonic motility and relieve occasional constipation, the formula pairs Cascara Sagrada bark (300 mg) with Organic Senna leaf (300 mg), which contain natural anthraquinones that trigger gentle peristaltic contractions. To offset cramping and support intestinal comfort, the blend incorporates Organic Aloe Vera inner leaf (100 mg) and Licorice root (50 mg) to soothe delicate mucosal linings, alongside Fennel seed (50 mg) to provide carminative action that eases bloating and gas. This protocol is intended for episodic use—taking 1 to 2 capsules at bedtime with at least 8 ounces of water for up to seven consecutive days. Because the formula contains stimulant botanicals, it is designed strictly for short Cycles with a recommended six-week break between programs to prevent bowel dependence. When paired with ample hydration and a post-cleanse probiotic or prebiotic routine, it serves as an effective periodic reset to restore digestive regularity and a lighter, less bloated feel.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6646) Does Methylation Effect Active Vitamin D3 Levels in the body?
Date:
July 08, 2026 12:43 PM
Yes, methylation directly and significantly impacts how efficiently your body converts Vitamin D3 into its active, usable form. This relationship operates on two distinct levels: epigenetic DNA methylation (which acts as a volume knob for the conversion enzymes) and the cellular methylation Cycle (which shares a profound reciprocal feedback loop with active Vitamin D). To see exactly where methylation interferes, it helps to look at the standard two-step activation pathway:
1. DNA Methylation (The Epigenetic "Dimmer Switch")DNA methylation is an epigenetic mechanism where methyl groups are attached to a gene's promoter region, typically silencing or "turning down" its expression.
2. The Systemic Methylation Cycle Feedback LoopWhile S-adenosylmethionine (SAMe) is not a direct chemical cofactor required for the hydroxylation reactions themselves (which rely on NADPH and the cytochrome P450 enzyme network), the systemic methylation Cycle and Vitamin D share a massive reciprocal cross-talk mechanism.
The Vitamin D "Non-Responder": Is Your DNA Dimming Your Supplement’s Power? Yes, higher active Vitamin D3 levels consistently cause homocysteine levels to drop. Large-scale observational studies and gold-standard randomized controlled trials (RCTs) confirm a distinct, inverse relationship: as your Vitamin D status optimizes, circulating total homocysteine decreases. When active D3 binds to the Vitamin D Receptor (VDR), it triggers specific genetic and cellular actions that clear homocysteine through multiple pathways. The Biological MechanismsActive Vitamin D doesn’t just lower homocysteine through one pathway; it exerts a multi-pronged push to keep the toxic amino acid from accumulating.1. Upregulation of Methionine Synthase (MTR)While active D3 supports the alternative BHMT (betaine) pathway, recent molecular research highlights an even more direct impact on the primary, folate-dependent remethylation loop.
2. Safeguarding Enzyme Function via Oxidative Stress ReductionThe primary enzyme responsible for clearing homocysteine, Methionine Synthase, is incredibly sensitive to oxidative stress. Under high inflammation or oxidative conditions, the cobalt atom at the heart of its B12 cofactor becomes oxidized, completely disabling the enzyme and causing a major homocysteine backup.
3. Preserving Liver and Kidney FunctionThe alternative remethylation pathway, BHMT, operates almost exclusively in the liver and kidneys. If these organs experience structural or metabolic strain, their capacity to process homocysteine drops drastically. Active Vitamin D protects hepatic and renal tissue architecture, ensuring the local cellular machinery required for the betaine-homocysteine conversion remains functional.What the Clinical Trials ShowIn human trials, the drop isn't just theoretical - it's highly measurable.The Clinical Evidence: In double-blind, randomized, placebo-controlled trials, individuals with low baseline Vitamin D and elevated homocysteine were given high-dose Vitamin D3 (e.g., 50,000 IU weekly) over a two-month period. The treatment groups consistently showed statistically significant drops in total serum homocysteine, alongside reductions in body mass index (BMI) and systemic inflammatory markers, while the placebo groups saw no change. If someone is dealing with stubborn hyperhomocysteinemia (elevated homocysteine) and pushing hard on methylated B-vitamins (like methylfolate and TMG/betaine) without seeing their numbers budge, a hidden Vitamin D deficiency or a high-methylation genetic barrier at the CYP2R1 liver enzyme is very frequently the missing link. Summary: The relationship between Vitamin D3 activation and the body's biochemical pathways operates as a highly coordinated, reciprocal feedback loop. On an epigenetic level, DNA methylation acts like a cellular dimmer switch for the liver enzyme CYP2R1, which is responsible for converting raw D3 into its circulating form. When the promoter region of this gene is heavily methylated, enzyme production is suppressed, explaining why some individuals act as clinical "non-responders" who struggle to raise their blood levels even with high-dose supplementation. Once Vitamin D is successfully activated, however, it turns around and directly reinforces the systemic methylation Cycle by binding to the Vitamin D Receptor (VDR) and upregulating the BHMT gene, which is vital for maintaining the body's universal methyl donor (SAMe) pool. Conversely, maintaining robust levels of active Vitamin D3 plays a direct, clinically proven role in forcing circulating homocysteine levels to drop. When active D3 binds to its receptor, it triggers a multi-pronged clearance strategy by activating the Nrf2 cellular defense pathway, which upregulates Methionine Synthase (MTR) - the primary enzyme that converts toxic homocysteine back into harmless methionine. Furthermore, by acting as a powerful systemic anti-inflammatory, active Vitamin D lowers the oxidative stress that would otherwise oxidize and disable the delicate B12 cofactors inside these clearance enzymes. This dual action of increasing enzyme production while shielding existing enzymes from environmental damage explains why clinical trials consistently show significant reductions in serum homocysteine when Vitamin D status is optimized.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6644) Choline: The Liver’s Fat-Export Engine
Date:
June 24, 2026 11:48 AM
Without sufficient choline, the liver's ability to process and export fats grinds to a halt. The Liver’s Fat-Export MechanismThe primary reason the liver requires choline comes down to a specific molecule: phosphatidylcholine (PC).When you eat fats or liberate stored fatty acids, your liver processes them into triglycerides. To move these triglycerides out of the liver and deliver them to muscle or adipose (fat) tissue for energy or storage, the liver has to package them into transport vehicles called VLDL (Very Low-Density Lipoproteins). Phosphatidylcholine forms the essential outer shell of these VLDL transport "boats." If you don't have enough choline, your liver cannot manufacture this outer shell, meaning the boats cannot be built, and fat cannot leave the liver. What Happens When Choline is Deficient?When dietary choline drops below critical levels, a highly predictable cascade of liver dysfunction occurs:
Dietary Benchmarks & SourcesTo prevent fat accumulation and support proper VLDL export, the Food and Nutrition Board establishes specific Adequate Intake (AI) targets, though optimal metabolic and athletic performance may require a more robust baseline.
Summary: Choline acts as a critical logistics coordinator for liver health, serving as a non-negotiable raw material for exporting fat out of the organ. Specifically, the liver relies on choline to produce phosphatidylcholine, a molecule that forms the essential outer shell of Very Low-Density Lipoproteins (VLDL). Think of VLDLs as transport boats designed to safely carry triglycerides out of the liver and deliver them to the rest of the body for energy or storage. Without an adequate dietary supply of choline, the liver simply cannot build these outer shells, causing the entire transport system to grind to a halt and leaving processed fats stranded inside liver cells. When this export mechanism stalls, the stranded fat quickly triggers a highly predictable cascade of liver dysfunction. This buildup leads directly to fat accumulation - historically known as fatty liver disease and now classified as MASLD - which quickly overwhelms the cellular mitochondria. The resulting oxidative stress and cellular injury spark chronic inflammation (MASH), causing liver cells to die and potentially leading to permanent scarring or fibrosis over time. Furthermore, a severe shortage of dietary choline starves the body's methylation Cycle, forcing it to deplete vital SAMe pools in a desperate, structurally taxing attempt to manufacture its own phosphatidylcholine.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6643) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation Cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation Cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6640)
Date:
May 21, 2026 03:43 PM
If you supplement with high doses of DMAE without adequate methyl support, you may inadvertently "drain" your methyl pool. This can lead to:
Summary: While DMAE offers potent cellular cleaning and membrane protection, it functions best when the body has a robust supply of methyl donors to handle its conversion without taxing the system.
To make this conversion efficient, the body requires specific methyl donors and enzymatic co-factors.
Summary:
Supplementing with DMAE (dimethylaminoethanol) creates a unique biochemical dynamic in the body, particularly regarding cognitive performance and cellular longevity. While DMAE crosses the blood-brain barrier effectively, its conversion into the crucial neurotransmitter acetylcholine requires an additional methyl group, a process that can significantly drain the body's universal methyl donor, SAMe. To prevent this "methyl drain" and avoid issues like elevated homocysteine, it is highly beneficial to pair DMAE with strategic co-factors and methyl donors such as TMG (trimethylglycine) and methylated B-vitamins. Beyond its role in acetylcholine production, DMAE supports longevity through distinct cellular mechanisms that standard choline cannot replicate, specifically by neutralizing free radicals to stabilize cell membranes and flushing out lipofuscin, an age-related cellular waste product.
When evaluating whether to replace DMAE with direct choline supplementation for cost and efficiency, the decision hinges on your specific physiological goals. Standard budget options like choline bitartrate are highly cost-effective for general liver health and systemic cell structures, but they suffer from very poor brain penetration. Conversely, premium forms like Alpha-GPC and CDP-Choline are far more efficient for cognitive optimization and memory because they cross the blood-brain barrier effortlessly without taxing the body's methylation Cycle. Ultimately, while cheap choline salts cannot replicate DMAE's unique cellular cleaning properties, choosing a premium choline source is a more direct and biochemically efficient path for raw cognitive enhancement, especially if you want to avoid the multi-step metabolic cost associated with converting DMAE.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6638)
Date:
April 15, 2026 02:04 PM
When you are under stress, your cells can become flooded with calcium, which "excites" the cell. Magnesium sits at the "gate," ensuring that only the necessary amount of calcium enters. Without enough magnesium, cells become hyper-excitable, leading to oxidative stress, inflammation, and even cell death. Furthermore, magnesium is a required co-factor for the production and stability of ATP (adenosine triphosphate), the primary energy currency of the cell. In fact, ATP is usually found in the body as a complex called Mg^2+-ATP.
However, many functional medicine experts argue this number is actually higher because the RDA is designed to prevent acute deficiency, not to optimize health. Furthermore, magnesium is stored in bones and soft tissue, not the blood, meaning standard "Serum Magnesium" blood tests often miss a deficiency until it is dangerously low.
Unlike Magnesium Oxide (which has poor absorption) or Magnesium Citrate (which can have a laxative effect), Magnesium Glycinate is chelated with the amino acid glycine. This makes it:
Here are the additional benefits you might notice once your magnesium "tank" is full:
Magnesium acts as the body's essential "biological coolant," stabilizing cellular integrity by regulating calcium influx and powering nearly every metabolic process as a co-factor for Mg^2+-ATP. Despite its critical role, more than half of the American population remains chronically deficient, a silent crisis fueled by mineral-depleted industrial soil and the stripping of nutrients during food processing. Transitioning to a high-quality supplement like Magnesium Glycinate offers a superior path to replenishment because its chelated form is both highly bioavailable and gentle on the digestive system. Once levels are restored, the systemic "re-tuning" manifests as a profound shift in well-being, ranging from enhanced sleep quality and stress resilience to improved bone density, hormonal balance, and DNA repair, effectively moving the body from a state of hyper-excitable stress to one of optimized physiological stability.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6637)
Date:
April 11, 2026 12:24 PM
Note: While NMN is widely studied in animal models with promising results regarding lifespan and healthspan, human clinical trials are ongoing to fully confirm long-term efficacy and optimal dosage. Always consult a healthcare professional before starting new supplements.
Here are the vital pieces of the NAD+ puzzle that aren't usually mentioned:
Are you planning to focus your blog post on the anti-aging benefits for a general audience, or would you like to lean more into the technical "biohacking" side of science?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6636)
Date:
December 05, 2025 04:06 PM
Since mitochondria produce about 90% of the energy (ATP) your body uses, improving their function is like upgrading the engine in a car: you get more power, better fuel efficiency, and a smoother ride.
Here is the breakdown of how boosting mitochondria translates to "feeling better" physically and mentally.
Here are the top supplements with the strongest evidence for mitochondrial health, categorized by how they work.
Optimizing mitochondrial health is a systemic strategy that links gut health to overall vitality, largely driven by Short-Chain Fatty Acids (SCFAs) like butyrate, which act as both fuel and signaling agents to enhance energy production in the brain, muscles, and liver. By stimulating mitochondrial biogenesis (the creation of new energy factories via the PGC-1a gene) and fueling the Electron Transport Chain, SCFAs - along with targeted supplements like PQQ, CoQ10, and Urolithin A - directly increase ATP output while simultaneously clearing out damaged cells through mitophagy. This biological upgrade results in tangible benefits, including sustained physical endurance, sharper cognitive focus, and stabilized mood, effectively turning the body’s cells into more efficient engines that produce more power with less oxidative "exhaust."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6630)
Date:
November 20, 2025 12:16 PM
In the context of the colon, the paradox states that butyrate is a promoter of life for healthy colon cells but an inducer of death (apoptosis) for colon cancer cells.
Regarding its effects on all cancers throughout the body, studies show that butyrate's pro-apoptotic (death-inducing) properties are not limited to colon cancer, but the paradox itself is largely defined by the unique metabolic environment of the colon.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6629)
Date:
June 01, 2024 10:58 AM
In the quest for beauty, many often look to skincare products and treatments, yet one of the most effective pathways to radiant skin and overall health is through regular physical activity. Exercise offers an array of benefits that enhance beauty from within, contributing to healthy skin, a glowing complexion, and a fit physique. This article explores how fitness plays a crucial role in beauty and well-being, suggests exercise routines that promote beauty from within, and recommends a supplement to boost hair and skin health.
When you engage in physical activity, your heart pumps more blood, increasing circulation throughout the body. This enhanced blood flow delivers essential nutrients and oxygen to your skin cells, promoting cell regeneration and elasticity. Improved circulation also assists in flushing out toxins, contributing to clearer and more vibrant skin.
Stress is a significant contributor to numerous skin concerns such as acne, eczema, and psoriasis. Regular exercise can help reduce stress by releasing endorphins, the body's natural mood enhancers. Lower stress levels can result in fewer breakouts and a reduction in skin flare-ups, ultimately leading to a more serene and healthy appearance.
Engaging in activities that make you sweat, such as running, cycling, or hot arobics, can help detoxify your skin. Sweating helps to open up pores and remove dirt and impurities, giving your skin a natural detox. Remember to cleanse your face thoroughly after sweating to prevent any potential buildup of bacteria.
Exercise helps to boost collagen production, a protein that maintains skin's firmness and elasticity. High-intensity workouts and strength training, in particular, can stimulate collagen synthesis, leading to tighter, more youthful-looking skin.
Regular exercise can improve your sleep patterns, which in turn benefits your skin. During deep sleep, the body works to repair and regenerate cells, including skin cells. Better sleep can result in fewer dark circles, reduced eye puffiness, and a more rested appearance overall.
Hormonal imbalances can cause various skin problems, including acne and premature aging. Exercise helps regulate hormones, stabilizing levels of cortisol, estrogen, and testosterone, which are crucial for maintaining healthy skin.
Running and Jogging Running and jogging are excellent ways to boost circulation, enhance cardiovascular health, and induce sweating, which can help detoxify the skin. Cycling Cycling, whether outdoors or on a stationary bike, improves blood flow to the skin, reduces stress, and can be a fun way to stay active. Swimming Swimming is a low-impact exercise that increases circulation, tones muscles, and has the added benefit of keeping skin hydrated due to the water environment.
Weightlifting Incorporating weightlifting into your routine can boost collagen production and improve skin elasticity. Focus on compound movements like squats, deadlifts, and bench presses for maximum effect. Resistance Band Exercises Using resistance bands can help build muscle and enhance circulation without putting too much strain on your joints. These exercises are great for improving muscle tone and skin firmness.
Arobics Arobics not only improves flexibility and muscle tone but also reduces stress and promotes a better sleep Cycle, which are all beneficial for your skin. Floor leg lifts with dumbells and crunches and lateral lifts on the floor can increase blood flow to the face, enhancing your complexion. Pilates Pilates focuses on core strength, posture, and flexibility. The controlled movements and emphasis on breathing can improve circulation and reduce stress, contributing to overall skin health. Tai Chi Tai Chi is a gentle form of martial arts that reduces stress, improves flexibility, and enhances balance. It’s an excellent way for people of all ages to promote overall well-being and skin health.
HIIT workouts involve short bursts of intense exercise followed by rest periods. This type of training is highly effective for boosting metabolism, increasing collagen production, and promoting healthy, radiant skin. Exercises like burpees, jump squats, and sprinting can be incorporated into a HIIT routine.
While a balanced diet and regular exercise are vital for maintaining healthy skin and hair, supplements can provide an additional boost. Nutritional supplements can fill in dietary gaps, ensuring that your body gets the essential vitamins and minerals it needs to support glowing skin and strong, vibrant hair.
Biotin Biotin, also known as Vitamin B7, is crucial for hair and skin health. It supports the structure of keratin, a protein that makes up your hair, skin, and nails. Regular intake of biotin can help reduce hair loss, strengthen nails, and improve skin's overall appearance. Collagen Collagen is a protein that provides structure and elasticity to your skin. As we age, collagen production decreases, leading to wrinkles and saggy skin. A collagen supplement can help replenish this essential protein, promoting firm, youthful-looking skin. Combining Biotin and Collagen For optimal results, opt for a supplement that combines both biotin and collagen. This combination can provide comprehensive support for your beauty regimen, enhancing skin elasticity and hydrating hair follicles from within.
When selecting a supplement, look for products that are:
Take your supplement consistently, as directed by the packaging, to see the best results. It's also beneficial to combine your supplement intake with a balanced diet rich in fruits, vegetables, lean proteins, and healthy fats.
Integrating regular physical activity into your lifestyle is a powerful way to achieve glowing skin and overall well-being. From improved circulation to reduced stress, the benefits of exercise extend beyond physical fitness, promoting beauty from within. By incorporating a mix of cardiovascular exercises, strength training, and mind-body workouts, you can enhance your natural radiance. Additionally, supporting your fitness routine with a biotin and collagen supplement can provide further benefits for your hair and skin health. Remember, beauty is not just skin deep—it’s a reflection of a healthy, balanced lifestyle.
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Date:
May 29, 2024 11:28 AM
Vitamin B12, or cobalamin, is crucial for red blood cell production, DNA synthesis, and nervous system health. Among its many roles, one of the most vital is its contribution to energy production and metabolism. This article delves into how Vitamin B12 affects energy levels, with a particular focus on its importance for vegetarians and vegans.
Vitamin B12 is a water-soluble vitamin that is naturally found in animal products such as meat, dairy, and eggs. It is primarily responsible for converting food into ATP (adenosine triphosphate), which the body uses for energy. B12 is also crucial in the formation of red blood cells, which carry oxygen to every part of the body, and in maintaining the health of nerve cells.
Vitamin B12 is a key player in metabolism, a complex set of chemical reactions in our body that convert food into energy. One of the primary ways B12 contributes to metabolism is through its involvement in the Krebs Cycle, a series of reactions that produce ATP (adenosine triphosphate), the body's primary energy currency. During the Krebs Cycle, Vitamin B12 helps convert fats and proteins into energy, ensuring that the body has a constant supply of fuel to perform everyday tasks.
Vitamin B12 is also essential for DNA synthesis and cell division. It works closely with folate (Vitamin B9) to synthesize DNA during cell division. Rapidly dividing tissues, such as red blood cells, require an adequate supply of B12. A deficiency in this vitamin can lead to megaloblastic anemia, a condition where red blood cells are larger than normal and not as effective in transporting oxygen, thereby causing fatigue and weakness.
One of the significant challenges for vegetarians and vegans is getting enough Vitamin B12, as it is predominantly found in animal products. Plant-based diets generally lack this vitamin, putting individuals at risk of deficiency. However, several fortified foods and supplements can help prevent this deficiency.
Many plant-based milk alternatives, breakfast cereals, and nutritional yeasts are now fortified with Vitamin B12. For instance, a cup of fortified soy milk can provide about 50% of the daily recommended intake of B12. Additionally, B12 supplements are readily available and can be an effective way for vegetarians and vegans to ensure they get their daily dose. It's crucial to choose a supplement that meets the dietary needs and preferences of the individual.
A lack of Vitamin B12 can result in various health problems like fatigue, weakness, constipation, loss of appetite, and weight loss. In severe cases, it may lead to neurological issues such as numbness and tingling in the hands and feet, balance difficulties, depression, confusion, and memory loss. Given these risks, it's essential for vegetarians and vegans to monitor their B12 levels.
Adequate intake of Vitamin B12 can significantly enhance energy levels. Since B12 is involved in converting food into ATP, sufficient levels of this vitamin can help ensure that the body efficiently produces and uses energy. Individuals who maintain appropriate B12 levels often report feeling more energetic and less fatigued.
By ensuring a sufficient supply of B12, vegetarians and vegans can support their metabolic functions. A well-functioning metabolism is crucial for maintaining body weight, supporting muscle function, and ensuring overall vitality. Improved metabolic function also means better handling of the foods consumed, leading to more stable energy levels throughout the day.
Vitamin B12 is essential for producing neurotransmitters that regulate mood. Adequate levels of B12 can help prevent mental health issues such as depression and brain fog, which are often associated with fatigue and low energy levels. Regular intake of B12, either through diet or supplements, can contribute to better mental clarity and emotional well-being.
B12 is crucial in maintaining the myelin sheath, a protective coating around nerves. A healthy nervous system ensures that signals travel efficiently between the brain and the rest of the body. This not only helps in preventing neurological issues but also ensures that the body's energy systems operate smoothly.
For vegetarians and vegans, regular blood tests are an effective way to monitor B12 levels. These tests can help identify a deficiency early on, allowing individuals to take corrective measures before any severe symptoms manifest.
A well-rounded, balanced diet that includes fortified foods can help meet the daily recommended intake of Vitamin B12. Incorporating a variety of B12-fortified foods into every meal ensures a steady supply of this vital nutrient.
For those who struggle to get enough Vitamin B12 through diet alone, supplements are an excellent option.
When selecting a Vitamin B12 supplement, methylcobalamin, or methyl B12, is often recommended as the best form. It has superior bioavailability compared to cyanocobalamin, making it easier for the body to absorb and utilize. Methyl B12 doesn't need conversion in the body to be effective, leading to quicker uptake and immediate benefits. For vegetarians and vegans at higher risk of B12 deficiency, methyl B12 is especially beneficial for maintaining optimal B12 levels effectively. Including this form in your supplement routine can boost energy, mental clarity, and support metabolic and nervous system functions.
Raising awareness about B12 is key for vegetarians and vegans to prevent deficiencies. Health programs can educate on maintaining adequate levels through diet and supplements.
Vitamin B12's role in energy production and metabolism is indisputable. Vegetarians and vegans can struggle to get enough B12 from plant-based diets, but fortified foods and supplements offer solutions. Understanding B12's importance and taking action can boost energy, metabolism, and well-being. Regular monitoring, a balanced diet, and appropriate supplementation are key strategies to prevent deficiency and maintain optimal health.
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Date:
November 04, 2022 10:33 AM
Tart cherry is a type of cherry that is known for its sour taste. However, recent research has lead to increased interest in the cherry for its health-promoting benefits. Cherries contain anthocyanins, which are responsible for the red color of the fruit. Anthocyanins are considered antioxidants, which have free radical neutralizing properties.
Gout and Arthritis
One of the most well-known benefits of tart cherry is its ability to help the body fight gout and arthritis. Gout is a type of inflammatory arthritis that affects approximately 8.3 million people in the United States. symptoms include severe pain, swelling, and stiffness in the joints. Tart cherry has been shown to reduce these symptoms by reducing inflammation.
Heart Health
Tart cherries are also good for heart health. Several studies have shown that tart cherry intake can help reduce blood pressure and cholesterol levels. Additionally, tart cherries can help reduce inflammation markers in the blood, which is important for overall heart health.
Brain Health
Tart cherries are also being studied for their potential role in brain health. One study found that people who consumed tart cherry powder daily for 12 weeks had improved cognitive function and memory compared to those who did not consume the powder. Additionally, tart cherry intake has been shown to increase levels of melatonin, which is a hormone that helps regulate sleep Cycles.
Overall, tart cherry is a nutritional powerhouse with many potential health benefits. If you're looking for a natural way to improve your gout or arthritis symptoms, lower your blood pressure or cholesterol levels, or memory and cognitive function, incorporating tart cherry into your diet is a great place to start.
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Date:
October 27, 2022 12:10 PM
L-Tryptophan is an essential amino acid that the body needs to function properly, but cannot produce on its own. L-Tryptophan is critical for the production of serotonin and melatonin, which play important roles in maintaining a positive mood, regulating healthy sleep patterns, and supporting a strong immune system. Every lot of NOW L-Tryptophan is rigorously tested to ensure purity and potency.
Serotonin is an important neurotransmitters that help to regulate sleep, mood, and immunity.* When tryptophan crosses the blood-brain barrier, it is converted into serotonin.* serotonin helps to promote feelings of happiness and well-being.* A portion of serotonin is then converted into melatonin.* Melatonin is a hormone that helps to regulate the body’s natural sleep-wake Cycle.*
L-Tryptophan is found in many common foods such as turkey, chicken, eggs, milk, nuts, and seeds. However, the amount of L-Tryptophan in food is often not enough to produce the desired effect. Supplementing with L-Tryptophan can be an effective way to increase your serotonin and melatonin levels, and support overall health and wellness.
In Summary:
L-Tryptophan is an essential amino acid that plays a key role in regulating mood, sleep, and immunity. If you are not getting enough L-Tryptophan from your diet, supplementing with this nutrient can be an effective way to support your overall health and wellbeing.
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Date:
October 26, 2022 04:58 PM
Many people are not familiar with the term "citrulline." Citrulline is a non-essential amino acid that plays an important role in the urea Cycle. The urea Cycle is a process in the body that helps get rid of ammonia, which is a by-product of protein metabolism. Citrulline also helps with the healing process and in maintaining a healthy immune system.* In this blog post, we will explore the various benefits of citrulline and how it can help improve your health.
The Various Benefits of Citrulline
Citrulline has many benefits that can help improve your overall health.* Some of these benefits include:
In Summary:
Citrulline has many benefits that can help improve overall health.* If you are looking for a way to boost nitric oxide levels or enhance your exercise performance, consider adding citrulline to your diet. Citrulline supplementation can also aid in weight loss.* Consult with a healthcare professional before taking any supplements.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Date:
October 21, 2022 12:12 PM
L-Histidine is an essential amino acid that plays a role in a variety of important bodily functions. Histidine is best known for its role in the production of histamine, an important mediator of immune system responses. However, histidine is also critical for normal brain function and for the maintenance of a healthy skin barrier. In addition, histidine plays important roles in muscle function, cardiovascular health, protection against free radicals, and the elimination of heavy metals from the body. Let's take a closer look at some of these benefits.
The Role of Histamine in the Immune System Response
As we mentioned before, histamine is an important mediator of immune system responses. When your body comes into contact with a foreign invader, such as a virus or bacteria, mast cells release histamine into the bloodstream. This leads to the dilation of blood vessels and increased permeability of capillaries, which allows white blood cells and other immune cells to more easily reach the site of infection. In addition, histamine release triggers sneezing and increased mucus production, which helps to expel foreign invaders from the body.*
Histamine and Brain Function
Histamine is also involved in regulating wakefulness and sleep Cycles.* In fact, l-histidine deficiency has been linked to insomnia.* Histamine regulates serotonin levels in the brain and has been shown to improve cognitive function.* Additionally, histamine plays a role in memory formation and has even been shown to protect against age-related cognitive decline.*
L-Histidine and Cardiovascular Health
L-histidine has also been shown to have protective effects on the cardiovascular system.* Histamine promotes vasodilation—the widening of blood vessels—which can help to lower blood pressure.* L-histidine also inhibits platelet aggregation—the clumping together of blood cells—which can help to prevent blood clots from forming.* These effects can help to reduce the risk of heart attack and stroke.*
As you can see, l-histidine is involved in a variety of important bodily functions. From its role in immunity and brain function to its protective effects on the cardiovascular system, l-histidine is an amino acid that offers many benefits. If you are looking for a way to boost your health and well-being, consider adding l-histidine to your diet!
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Date:
September 24, 2022 10:26 AM
Pyruvate is a biochemical compound that’s involved in a number of metabolic processes in the body, including the metabolism of fat, proteins, and carbohydrates, the storage of glycogen, and the production of cellular energy.* Pyruvate is necessary for the citric acid Cycle (or Krebs Cycle), which is the process through which our cells produce energy in the form of adenosine triphosphate (ATP).* ATP is the body’s primary chemical fuel and powers many vital functions, including energy production, muscle contraction, and cellular fuel replenishment.* In short, pyruvate is essential for maintaining a healthy body. Let’s take a closer look at some of the specific ways in which pyruvate benefits the body.
The Role of Pyruvate in Metabolism
As we mentioned above, pyruvate plays an important role in metabolism—specifically, the metabolism of fat, protein, and carbohydrates. Pyruvate is involved in three different metabolic pathways: glycolysis (the breakdown of glucose), gluconeogenesis (the synthesis of glucose from non-carbohydrate sources), and the citric acid Cycle (also known as the Krebs Cycle or tricarboxylic acid Cycle).*
The role of pyruvate in metabolism is twofold. First, pyruvate acts as an intermediary molecule in the conversion of glucose to ATP. Second, pyruvate initiates gluconeogenesis—the process by which glucose is synthesized from non-carbohydrate sources—by conversion into oxaloacetate.* This process occurs when there is not enough carbohydrate available for fuel or when additional glucose is needed for glycogen storage.*
The Benefits of Pyruvate Supplements
Pyruvate supplements have become popular in recent years as a weight loss aid.* Pyruvate has been shown to boost metabolism and promote thermogenesis—the process by which our bodies convert food into heat and energy.* In one study, participants who took 2.5 grams of pyruvate per day for six weeks lost significantly more weight and body fat than those who didn’t take pyruvate.* In another study, participants taking 3 grams of pyruvic acid per day for 12 weeks reduced their body fat mass by an average of 3.5 kilograms (7.7 pounds) compared to those taking a placebo.*
In Summary:
Pyruvate is a biochemical compound with a variety of functions in the human body. Most importantly, it plays a role in metabolism—specifically, the metabolism of fat, proteins, and carbohydrates. It also initiates gluconeogenesis—the process by which glucose is synthesized from non-carbohydrate sources—by conversion into oxaloacetate. Additionally, pyruvate has become popular in recent years as a weight loss aid due to its ability to boost metabolism and promote thermogenesis. Supplementing with pyruvic acid can help you lose weight and achieve your desired body composition.
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Date:
September 14, 2022 04:03 PM
Most people know they should be getting around eight hours of sleep per night, but according to the National Sleep Foundation, between 50 and 70 million U.S. adults havea sleep disorder*. That means many of us are not getting the quality sleep we need on a nightly basis. But what does that mean for our health? Let’s take a look.
Short-Term Effects of Sleep Deprivation
There are many short-term effects of not getting enough sleep, including:
* Difficulty concentrating or making decisions * Increased forgetfulness * Moodiness or irritability * Slow reflexes * Increased anxiety * Decreased sex drive * Weight gain or weight loss * Heightened senses * Increased susceptibility to colds and flus
Long-Term Effects of Sleep Deprivation
The long-term effects of sleep deprivation are even more concerning. Some of the long-term effects of not getting enough sleep include:
* High blood pressure * Diabetes * Heart disease * Mood disorders such as depression or anxiety * Memory problems * weakened immune system * Increased pain perception Conclusion: As you can see, there are many short-term and long-term effects of not getting enough sleep. If you think you might have a sleep disorder, talk to your doctor about treatment options. In the meantime, practice good sleep hygiene by avoiding caffeine before bedtime, establish a regular sleep schedule, and create a calming bedtime routine. Do your best to get seven to eight hours of quality sleep every night so you can wake up feeling refreshed and ready to take on the day!
Need more sleep try melatonin!
What is Melatonin?
Melatonin is a hormone that helps regulate our sleep-wake Cycles. It's produced naturally by our bodies in response to darkness and starts to increase in the evening as we prepare for bed.
How Does Melatonin Work?
Many people take melatonin supplements in an effort to improve their sleep quality. And there is some evidence to suggest that it can be helpful. One small study found that melatonin supplements helped people fall asleep faster than placebo pills did. However, the effects were only temporary, lasting for just three days.
Another study looked at the effects of melatonin on people with insomnia due to jet lag. This research found that melatonin supplements shortened the time it took for participants to fall asleep by about an hour on average.
It's important to note that these studies looked at short-term usage of melatonin supplements. There's not much research available on the long-term effects of taking this supplement.
If you're struggling to get enough sleep, you might be wondering if supplements could help. One popular option is melatonin. But what is it, and does it really work? Melatonin is a hormone that helps regulate our sleep-wake Cycles which is produced naturally by our bodies in response to darkness.. Many people take melatonin supplements in an effort to improve their sleep quality and there is some evidence to suggest that it can be helpful such as one small study found that melatonin supplements helped people fall asleep faster than placebo pills did.. however the effects were only temporary lasting three days or another study which looked at the effects of melatonin on people with insomnia due to jet lag and found that it shortened the time it took participants to fall asleep by an hour on average...
Give Melatonin a try and sleep better!
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Date:
July 06, 2022 11:45 AM
What is IGF-1 and what are the benefits for men?
IGF-1, or Insulin-Like Growth Factor 1, is a hormone that occurs naturally in the human body. It is similar to insulin in structure and function, and it plays an important role in regulating cell growth. IGF-1 levels are highest during childhood and adolescence, when the body is growing rapidly. However, levels begin to decline in adulthood. Some research has suggested that declining IGF-1 levels may be linked to age-related health conditions such as muscle loss and osteoporosis. Supplementing with IGF-1 has been shown to increase muscle mass and strength, improve bone density, and reduce the risk of age-related diseases. For these reasons, IGF-1 supplementation is often recommended for older adults.
How can you increase your IGF-1 levels?
Deer antler velvet extract is one such supplement that has been shown to be effective in increasing IGF-1 levels. The extract is derived from the antlers of deer, which are naturally high in IGF-1. In addition to increasing IGF-1 levels, deer antler velvet extract has also been shown to improve athletic performance, increase strength and stamina, and reduce inflammation. As a result, it is an effective way to boost IGF-1 levels and improve overall health and well-being.
How to Cycle IGF-1 for maximum results?
It is produced naturally by the liver, but it can also be injected into the body through synthetic means. IGF-1 has a number of different benefits, including the promotion of muscle growth, the healing of wounds, and the prevention of age-related diseases. However, it is also important to Cycle IGF-1 in order to avoid potential side effects. When used correctly, IGF-1 can help to improve physical performance, accelerate recovery from injury, and delay the aging process. One can Cycle deer antler velvet extract which is high in IGF-1 on 8 weeks, off 4 weeks back on again.
Keep in mind, taking IGF-1 and working out is good, but if you are not getting enough protein, one can not build muscle like they could when consuming 1 gram of protein per body pound. IGF-1 is an important hormone in the body that helps with muscle growth, but if protein intake is low, it will be difficult to see results. Be sure to not only supplement with IGF-1, but also get adequate protein through diet or supplementation (protein powders).
If you are looking for a way to improve your health and well-being, you may want to consider taking deer antler velvet extract. The extract is derived from the antlers of deer, which are naturally high in IGF-1. In addition to increasing IGF-1 levels, deer antler velvet extract has also been shown to improve athletic performance, increase strength and stamina, and reduce inflammation. As a result, it is an effective way to boost IGF-1 levels and improve overall health and well-being. Thanks for reading! We hope this post has been informative and helpful. If you have any questions, please feel free to contact us.
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Date:
June 23, 2022 01:46 PM
Myocarditis is a condition that affects the heart muscle. It can be caused by a variety of things, including infection, autoimmune diseases, and even certain medications. Left untreated, myocarditis can lead to heart failure or even death. Thankfully, there are many natural ways to treat this condition. We will discuss the anti-inflammatory supplements and herbs that can help strengthen your heart and improve your health!
What is myocarditis and what are the symptoms?
Myocarditis is an inflammation of the heart muscle. The condition can be caused by a viral infection, autoimmune disease, or exposure to certain drugs or toxins. Symptoms of myocarditis include chest pain, shortness of breath, and irregular and/or rapid heartbeat. In severe cases, myocarditis can lead to heart failure. Treatment for myocarditis typically involves rest and limiting physical activity. In some cases, medication may also be necessary to reduce inflammation and prevent complications.
How can anti-inflammatory supplements and herbs help treat myocarditis naturally?
Herbs and supplements that have anti-inflammatory properties can be helpful in treating myocarditis, according to recent studies. Myocarditis is an inflammation of the heart muscle, and can be caused by a viral infection, autoimmune disease, or exposure to toxins. The condition can lead to arrhythmias, congestive heart failure, and even death. While there is no cure for myocarditis, treatment focuses on reducing inflammation and preventing further damage to the heart. Several herbs and supplements have been shown to have anti-inflammatory properties, including turmeric, ginger, and omega-3 fatty acids. In addition, these natural remedies are generally well-tolerated and have few side effects. As a result, they may offer a safe and effective way to manage myocarditis.
What are some of the best supplements and herbs for treating myocarditis naturally?
Treatment for myocarditis typically focuses on relieving symptoms and supporting the heart. However, there are also a number of supplements and herbs that can be beneficial for treating myocarditis naturally. Turmeric is a potent anti-inflammatory agent that has been shown to be effective in treating myocarditis. CBD is another compound with anti-inflammatory properties that can help to reduce inflammation in the heart. Omega-3 fatty acids are also beneficial for reducing inflammation and supporting heart health. Hawthorne berry is a herb traditionally used for the treatment of heart conditions. It helps to improve circulation and reduce strain on the heart. D-ribose is a sugar molecule that is essential for energy production in the cell. It helps to support the metabolism and can be beneficial for those with myocarditis. CoQ10 is an antioxidant that helps to protect the heart from damage caused by free radicals. CoQ10 is also involved in the krebs Cycle the energy Cycle of each cell. Supplements can be helpful for treating myocarditis naturally.
How can I incorporate these supplements and herbs into my treatment plan for myocarditis?
Treatment typically involves a combination of medications, rest, and lifestyle changes. Some people also find that supplements and herbs can help to relieve symptoms and promote healing. Turmeric, CBD, omega-3 fatty acids, hawthorne berry, D-ribose, and CoQ10 are all thought to be beneficial for people with myocarditis. Speak with your doctor before taking any supplements, as some can interact with medications you may be taking for your condition. However, when used correctly, these supplements and herbs can be helpful in managing myocarditis.
Are there any risks associated with using these supplements and herbs to treat myocarditis naturally?
There are a few potential risks associated with using natural supplements to treat myocarditis. Some of these supplements, such as turmeric and omega-3 fatty acids, may thin the blood. As a result, people who are taking blood thinners should have their blood levels monitored regularly. Additionally, Hawthorne berry may lower blood pressure, so people with low blood pressure should use it with caution if on medication. Finally, while CoQ10 is generally considered safe, it can cause upset stomach in some people, always take supplements with food.
How can I ensure that I am getting the most benefit from these supplements and herbs in order to improve my heart health?
Always start out with the recommended dosage for a week, then slowly increase each as needed. Make sure you spread out the consumption of supplements over the entire day to help reduce inflammation all day and night long. For example, supplements can be taken at breakfast, lunch, dinner and bedtime. Taking supplements spread out through the day ensure you get the therapeutic benefits all day long.
Using natural supplements and herbs to treat myocarditis can be a beneficial way to manage the condition. These supplements can help to reduce inflammation, improve circulation, and protect the heart from damage. When used correctly, they can be an effective part of a treatment plan for myocarditis. However, it is important to speak with your doctor before starting any new supplement regimen. It is also important to start out slowly when taking these supplements and increase dosage gradually to ensure you get the most benefit. Taking supplements throughout the day can help ensure that you receive their therapeutic benefits all day long.
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Date:
May 11, 2022 12:19 PM
Did you know that melatonin is a powerful free radical scavenger? This means that it helps protect the body from damage caused by harmful molecules called radicals. Melatonin is also naturally produced in the pineal gland and is present in high amounts in the GI tract. We will discuss some of the ways that melatonin supports health and wellness.
Melatonin and the body
Melatonin is a hormone that is produced by the pineal gland in the brain. It is responsible for regulating the body's internal clock, or circadian rhythm. The production of melatonin increases at night, and decreases during the day. This hormone is also available in supplement form, and is often used to treat jet lag or insomnia. When taken as a supplement, melatonin works by resetting the body's internal clock, making it easier to fall asleep and stay asleep. Additionally, melatonin may also help to reduce anxiety and improve mood. As a result, this hormone plays an important role in regulating the body's sleep-wake Cycle.
How does melatonin support a healthy sleep Cycle?
Melatonin is a hormone that help regulate the sleep Cycle. The production of melatonin is stimulated by darkness and inhibited by light. As a result, melatonin levels typically start to rise in the evening as the sun sets, and they remain high throughout the night. In the morning, light exposure causes melatonin levels to drop, helping to wake us up and start the day. Melatonin supplements can be used to help people who have difficulty sleeping and staying asleep. This hormone helps to reset the body's natural sleep Cycle, making it easier to fall asleep and stay asleep. As a result, melatonin can be an effective way to support a healthy sleep Cycle.
What are some of the other benefits of melatonin?
It can help to boost the immune system, protect against cancer, and reduce inflammation. Research suggests that melatonin may also have neuroprotective effects and could be beneficial for people with Alzheimer's disease or Parkinson's disease.
Tips for getting a good night's sleep
Most people need about seven to eight hours of sleep a day. However, many people find it difficult to get enough rest. There are a number of things you can do to improve your sleep habits. First, create a regular sleep schedule and stick to it as much as possible. Go to bed and wake up at the same time each day, even on weekends. Second, create a relaxing bedtime routine. This might include taking a warm shower, reading a book, or writing in a journal. Third, create a comfortable sleep environment by making sure your bedroom is dark, quiet, and cool. Fourth, avoid caffeine and alcohol before bed. Caffeine can make it difficult to fall asleep and stay asleep, while alcohol can disrupt your sleep Cycle. Finally, try not to use electronic devices in bed. The blue light emitted by screens can interfere with your body's natural sleep rhythm and take melatonin. By following these tips, you can improve your chances of getting a good night's sleep.
Scientific research
Research on melatonin began in the 1950s, and since then, numerous studies have been conducted on its potential health benefits. Some of the most promising research has found that melatonin may help to prevent cancer. In one study, melatonin supplements were found to reduce the risk of breast cancer recurrence by half. Other research has shown that melatonin may help to protect against colon cancer, prostate cancer, and ovarian cancer. Additionally, melatonin has been shown to boost the effectiveness of chemotherapy drugs and radiation therapy.
While more research is needed to confirm the exact role of melatonin in cancer prevention, the available evidence suggests that it could play a significant role in protecting against this disease. Therefore, it may be worth considering supplementing with melatonin if you are at high risk for cancer or are undergoing treatment for this disease.
References:
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Date:
May 06, 2019 03:44 PM
Manuka honey is touted as a super food due to its numerous therapeutic benefits. Manuka honey is a strong antibacterial that can strengthen your immune system during flu season and all year-round. Because of its antimicrobial properties, manuka honey is particularly effective in soothing sore throats. Manuka honey is also quite good for oral health and can be used to prevent gingivitis. When purchasing manuka honey, be sure there is a UMF rating on the packaging, which shows that it has been tested for purity. A high UMF rating correlates to strong antibacterial properties and a potent flavor. Key Takeaways: "Manuka honey is a unique kind of honey from New Zealand. It comes from the manuka tree and has many therapeutic properties." Read more: https://www.naturalnews.com/2019-04-07-health-benefits-to-make-you-love-manuka-honey.html
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Date:
April 27, 2019 09:53 AM
Celery is known for being a low calorie vegetable that is also a good source of vitamins, minerals and dietary fiber. However, the biggest (and perhaps most overlooked) health benefit of celery lies in its cancer-fighting properties. Two important antioxidants found in celery - apigenin and luteolin - are the key. Among other benefits, Apigenin has been shown to inhibit the growth of tumors, while Luteolin interferes with cancer cells' replication cycles. Whether you eat it raw or incorporate it into smoothies, soups or stews, celery doesn't just taste good, it can extend your life. Key Takeaways: "Research has shown that celery contains two important antioxidants, called apigenin and luteolin, which have exhibited some potent chemopreventive effects." Read more: https://www.naturalnews.com/2019-03-06-is-celery-the-powerful-anti-cancer-weapon-we-have-all-been-waiting-for.html
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Date:
April 26, 2019 02:26 PM
There is a protective enzyme within pomegranate that is known scientifically as paraoxonase-1 (PON-1), and it has the ability to block oxidative stress that promote DNA mutations. These DNA mutations are often what lead to a cancer diagnosis. More research determined that not only does pomegranate help block gene mutations, but it can also stop the replication cycle of cancer cells in which they grow at alarming rates. Not only can it help disrupt this cycle, but it can also kill some cells altogether. Key Takeaways: "In one study, a cup of day of pomegranate juice lowered inflammatory markers – such as C-reactive protein and interleukin-6 – in diabetic patients." Read more: https://www.naturalhealth365.com/pomegranate-cancer-cells-2628.html
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Date:
April 19, 2019 02:20 PM
Studies are now showing that turmeric, which is a common spice found in curry, can actually help kill off colon cancer cells to help the disease from progressing. They believe that these healing properties are due to the curcumin content that is found within the spice itself. If you're searching for ways to take in adequate amounts of turmeric, try consuming turmeric tea. For a more savory option, turmeric tastes fantastic when sprinkled on roasted produce. Key Takeaways: "In this study, published in the journal Nutrition Research, the researchers hypothesized that curcumin-induced ROS works against colon cancer by promoting apoptosis and inhibiting the cell cycle. They tested this through in vitro experiments involving Smd4 and p53 mutated HT-29 colon adenocarcinoma cells." Read more: https://www.naturalnews.com/2019-02-27-common-curry-spice-turmeric-kills-colon-cancer-cells.html
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Date:
February 15, 2019 09:38 AM
In recent years, a very large focus has gone into using herbs and supplements to help boost problems humans are facing today. This article specifically touches on the herb maca and has been said to help aid in both physical and mental health, but can it help with fertility? It explores the possibility that by consuming this herb your sexual health and ability to reproduce can increase as well as help stabilize your bodies natural cycle. Additionally, it provides a few ways in which you can ultimately consume it. Key Takeaways: "Maca is a tuber native to South America and it is considered an Andean miracle food." Read more: https://www.naturalnews.com/2019-02-10-why-maca-is-one-of-the-best-natural-remedies-for-fertility-problems.html
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Date:
January 05, 2019 02:26 PM
New research from Penn State University has shown that being in a negative mood can be linked with higher levels of inflammation and may be a signal of poor health. Inflammation is a contributing factor to many diseases such as diabetes and cancer. These negative emotions include sadness, anger, and depression. 220 participants reported on their moods and blood samples were taken to measure the inflammation present in the body. This was the first study to research how the two are linked. The long-term goal of the researchers is that the information will eventually lead to insights into how interventions can improve mood and ability to cope with stress. That will in turn help break the cycle of disease associated with inflammation. Key Takeaways: "New US research has found that a negative mood, such as feeling sad or angry, may be linked with higher levels of inflammation and may be a sign of poor health." Read more: https://www.malaymail.com/s/1705392/new-study-links-negative-mood-with-higher-levels-of-inflammation
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Date:
October 10, 2018 03:26 PM
When it comes to treating liver cancer, milk thistle my be the key. For yes this prickly, purple plant has been used for good liver function and is sought out for its anti inflammatory and antimicrobial qualities. This plant extracts silibinin which has anti-cancer effects on cancer cells. It also inhibits the cancer cells cycle and increases the death of cancer cells. This plant also has another compound called silymarin which is supposed to be more enriching than Vitamin E. Key Takeaways: "New studies have shown that the protective benefits of milk thistle are far greater than conventional scientists could have ever imagined." Read more: https://www.naturalnews.com/2018-09-16-milk-thistle-shows-promise-in-treating-liver-cancer.html
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Date:
July 04, 2018 09:54 AM
D-Ribose is a simple sugar molecule that plays an important role in energy metabolism within your body by helping to produce cellular energy in the form of adenosine triphosphate (ATP). Oxidative stress can deplete ATP, which can then cause further stress, in a vicious cycle for your heart. However, D-Ribose supplements can restore levels of ATP, which can improve heart function and exercise endurance in cardiac patients. Infusion of D-Ribose after a cardiac event may even be able to prevent dangerous ischemia reperfusion injuries. Key Takeaways: "With one occurring every 40 seconds in America, you likely know more than a few people who have experienced one." Read more: https://www.naturalnews.com/2018-07-01-natural-sugar-molecule-d-ribose-improve-heart-function-and-blood-flow.html
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Date:
May 31, 2018 05:16 PM
Insomnia affects one-third of Americans. That shows many people are not having good sleep quality. CBD oil can help in this regard. It helps you to enter and maintain the non-REM phase of sleep (the deep sleep phase) while reducing the duration of the REM phase (the light sleep phase where dreams take place). The benefits are a marked increase in overall sleep quality and reduction of symptoms of depression and anxiety. So, even if you live in a very noisy environment, CBD oil can help you get that needed sleep. But before you chose on which oil to use, you should go for one that is environmentally-friendly and not made with toxic chemicals. Check whether the manufacturer allows third party lab testing. Also, the higher the price, the higher is the quality. Key Takeaways: "It may sound weird, but CBD is actually known to promote alertness, and thanks to that, it helps us sleep better." Read more: http://baltimorepostexaminer.com/will-cbd-oil-help-sleep/2018/05/29
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Date:
May 22, 2018 05:16 PM
Pyridoxamine (aka Vitamin B6) is a water soluble vitamin of the B Complex family with a range of important nervous system and stress regulation functions. B6 helps regular immunity, protect the skin, prevent cognitive decline (especially in seniors) and provide for a steady, healthy emotional state and sleep cycle. Foods rich in B6 run the gamut from plant-based sources like chickpeas, tofu, brown rice and avocados to beef liver, chicken breast, yellow tuna and other animal sources. Key Takeaways: "In the research test groups, it was shown that Vitamin B6 benefits cognitive health in such a way that it can significantly reduce serum total homocysteine (tHcy) levels. This process is especially helpful when B6 is taken in supplement form; even then, it can better aid cognitive health when used alongside additional vitamins such as B12." Read more: https://healthyfoodmaster.com/vitamin-b6-benefits-food-sources-dietary-allowance-deficiency/
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Date:
September 27, 2017 12:14 PM
People often go on diets because they want to lose weight. A good way to diet is by just substituting what you eat with healthier things. It's not good to eat much less, though, because your body needs certain nutrients and a certain amount of calories. This tells you what can happen to your brain if you do choose to diet. It might make you think a bit before doing so or at least before choosing an extreme one. Key Takeaways: "In fact, though the risks of yo-yo dieting have been contested, one 2016 study found that repeatedly going through these starvation cycles prompts your body to gain more weight." Read more: https://www.nbcnews.com/better/health/what-happens-your-brain-when-you-go-diet-ncna802626?cid=public-rss_20170920
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Date:
August 29, 2017 04:14 PM
There are 6 essential oils that work like Valium for your anxiety. Bergamot is one of these essential oils that people can use. Bergamot is a very sweet fruit and it is a part of the citrus family. It makes for a very good and calming oil. It has soothing and moos boosting properties. There have been studies done on this that have shown its healing properties. Orange is another essential oil that will work great for healing anxiety. Key Takeaways: "Geranium essential oil has been found to have both calming and refreshing properties, and it may especially help to soothe anxiety in women during those especially trying times in our monthly cycles." Read more: http://www.thealternativedaily.com/essential-oils-that-work-like-valium-for-anxiety/
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Date:
July 14, 2017 12:14 PM
We are all trying to look younger than we really are. Many of us color our hair to keep the gray away, but there is a natural option that works on dark colored hair that might be more appealing. Using coffee and black tea, along with water, you can create a concoction that can be sprayed on hair and will help cover gray. This can be done once a week to keep the dark color. It might be a better option for some since it uses no chemicals and will not damage the hair like hair dyes will. Try it to see if it's appropriate for your needs. Key Takeaways: "If you are already one of the people who already has gray hair, we will recommend an excellent natural recipe to cover the hair in a natural way."
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Date:
July 09, 2017 07:14 PM
Sleep is vitally important to our health and well being. Even if you lose one hour of sleep it can impact how your overall day will be. If a individual suffers from insomnia there are some creative ways to help them fall asleep. If you are in a different time zone it will take two weeks for your body to adjust to the sleep pattern. It is not the quantity of sleep that makes you rested, but the quality of sleep the person receives that makes them feel rested. Despite rumors, you may not "catch up" on sleep on the weekend if you missed sleep during the week. In fact, over sleeping on the weekend can further disrupt the sleep cycle on Sunday night when the person needs to wake up early the following Monday morning. Read more: Sleep: How much you really need?
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Date:
June 20, 2017 11:14 AM
Space travel could become a real viable option for most people in the very near future. But, you may ask, what kind of health problems can arise from traveling in outer space? Well, nutrition for one, could be an area of concern in space travel, since most food would consist of re-hydrated food pouches. Fresh foods during space travel are rare, so vitamins are a must to ensure proper health is maintained. Another health concern for a space traveler may be hygiene. While on board a space flight, water is limited. Showering and changing clothes daily may not be an option. Water is precious and even urine is recycled and reused. In addition, a person's mental health will certainly be tested from being in such a small confined area during the journey. Sleeping, as well, takes a little more thought, since falling asleep without being tethered could cause one to be injured or even float away! Lastly, the main health concern would probably be radiation exposure which could lead to cancer or "space brain," a condition that causes brain damage. These areas of health concern would need to be considered before deciding if boarding the next spacecraft is the right choice for your one of a kind vacation in the near future. Happy travels!! Read more: What Happens to Our Bodies in Space?
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Date:
May 25, 2017 12:14 PM
For those millions of people that have trouble sleeping, there is a natural remedy that is only comprised of three ingredients and can make you fall asleep quickly and safely as it relaxes your body. This recipe contains the natural ingredients of one tablespoon of coconut oil, one eight of a teaspoon of salt, and a quarter teaspoon of raw honey. This mixture is best taken before bedtime and can be taken two different ways. First, you can combine all ingredients and then consume a glass of water. Or, you can consume the honey and oil separately and then consume water with salt. All three ingredients help play a separate role in helping you sleep as they help secrete hormones to hep you sleep and make you wake up feeling better the next day. Key Takeaways: "There is a completely natural remedy that will restore your sleep and will help you wake up fresh and in a good mood."
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Date:
May 17, 2017 08:45 AM
If you have diabetes, you'll need to learn about and control several factors in your life if you want to control your blod sugar. Eat low carb, small portion meals timed around when you need your medicine. Stay hydrated and avoid sugary drinks. Develop an exercise plan with your doctor, then make an exercise schedule to incorporate it into your life. Frequently check your blood sugar, store your insulin propertly, and keep your doctor updated on any changes. Don't make changes to your diet or your insulin intake when you are ill. Talk to your doctor before drinking alcohol. Watch for cycles of erratic blood sugar during menstruation or if you have menopause. Lastly, log your stress level every time you take your insulin. Key Takeaways: "As much as possible, plan for every meal to have a good mix of starches, fruits and vegetables, proteins and fats." Read more: http://www.mayoclinic.org/diseases-conditions/diabetes/in-depth/diabetes-management/art-20047963
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Date:
March 16, 2017 01:44 PM
Valuable microscopic organisms might be the way to turning around a cycle of gut irritation found in certain fiery inside ailments, College of North Carolina Lineberger Far reaching Tumor Center scientists have found. Scientists found that including back a sort of advantageous microscopic organisms that ordinarily develops in the gut can help end this cycle, recommending another treatment for incendiary inside ailment. The two most basic fiery entrail infections, Crohn's illness, and ulcerative colitis influence an expected 1.6 million individuals in the Unified States, as indicated by the Crohns and Colitis Establishment of America. They trust their discoveries could conceivably prompt to medications for individuals with fiery gut illnesses with diminished NLRP12 expression. You can focus on the irritation that downstream of NLRP12 with mitigating medications, or you could simply nourish the creatures particular microscopic organisms that advantage, and it causes a move that made them less defenseless to the ailment. Key Takeaways: "NLRP12 has been known to suppress inflammatory signals to prevent an overactive immune response. But an analysis uncovered low levels of NLRP12 in twins with ulcerative colitis, but not in paired twins without the disease. And in mouse models that lacked this protein, they found higher levels of inflammation in the colon." Read more: https://www.sciencedaily.com/releases/2017/03/170313135055.htm
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Date:
February 28, 2017 07:59 AM
Research has shown that inflammation is to blame for a majority of health issues. Inflammation, in turn, is closely related to the foods that we consume in our diets. Highly acidic foods and those with lots of sugar can throw off our body’s balance, which uses inflammation as a way to fight for normality. If you want to end the Cycle of inflammation and health problems, try eating more fresh vegetables and avoiding overly processed foods. Make your diet high in leafy greens, turmeric, fish oils, nuts, and coconut oil, and you will see fewer health problems. Key Takeaways: "Our bodies need a very specific pH balance to function and maintain homeostasis." Reference:
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Date:
February 07, 2017 05:59 AM
It may seem like it impossible to not eat junk food, but you can break the Cycle. One of the main reasons people reach for junk food is because of learned ques. By trying to retrain yourself you may be able to break these bad habits. This is what new research shows, you may be able to beat these feelings. A way out of the junk-food eating Cycle
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Date:
December 25, 2016 07:59 AM
I love tea that has good benefits, but unfortunately I love all tea except for the flavor this one has. It makes me gag. Although, I need to somehow overcome and try to drink this, as it really helps with a few things I struggle with. For example, my menstrual Cycle is painful and very heavy, irregular as well. Key Takeaways: "Licorice is something you’ll always find in my grandma’s house. When we suffered from a sore, scratchy throat, she’d always give us a candy." Reference:
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Date:
December 20, 2016 06:08 PM
Olive leaf extract offers several health benefits that you cannot get from other types of extracts. It has a wide range of unique health properties that work against symptoms and diseases. Here are some of the major benefits.
One of the major benefits of olive leaf extract is that it has the ability to offer protection against breast cancer. The good thing is that it helps prevention of the escalation of the problem at an early stage in its growth Cycle.
Olive oil extract helps in stimulation of the production of bone building cells also referred as osteoblasts. This helps in prevention of the loss of bone density and helps in fighting osteoporosis.
The compounds found in olive leaf extract contain a unique feature that makes it have the ability to fight against different microorganisms such as viruses and bacteria. The compounds impair viruses, thus making them lack the ability to develop amino acids. This makes it impossible for them to reproduce and multiply. These compounds act against microorganisms in a way that antibiotics cannot.
Olive leaf extract has several phenols, which are antioxidants that help in neutralizing the action of free radicals. Free radicals refer to active substances that destroy the process of DNA creation.
Another common use of the olive oil extract is that it helps in treatment of various infections in the body. Oleuropein which is one of its major compound has anti microbial activity that helps reduce and boost inflammation. This means that it helps in reducing inflammation in the body.
Studies have showed that oleuropein has the ability to relax your blood vessels, reduce blood pressure and helps in prevention of blood clot formation. It also helps stop irregular heartbeat, balance blood sugar levels and improve flow of blood in the coronary arteries.
References
https://draxe.com/olive-leaf-benefits/
www.about-olive-leaf-extract.com/benefits-of-olive-leaf-extract.html
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Date:
December 10, 2016 06:59 AM
Dates have some amazing health benefits which make it a must to eat them daily. Even consuming three dates a day, can improve your health drastically, and also boost your immune system, while keeping health disorders and ailments at bay. Know health benefits of dragon fruit Dates help in increasing the iron levels in your blood which aids in curbing anemia. Next time you feel completely exhausted, you know what to have to regain your energy. Key Takeaways: "Dates are fibrous; the fibres it got are soluble which aids in grasping more water in the digestive tract which combats constipation." Reference:
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Date:
November 25, 2016 12:59 PM
A healthy diet can heighten chances of conception. Alcohol and junk food can reduce fertility health, but healthy foods such as fruits and vegetables can actually increase your chances. For example, avocados contain monounsaturated fat which produces healthier eggs. Beans and lentils contain iron (among other vitamins) which promotes ovulation. Even cinnamon can improve ovary function. Key Takeaways: "A healthy lifestyle can improve your chances of conceiving by protecting your fertility." Reference:
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Date:
November 21, 2016 01:09 PM
Pomegranates may hold a more significant role than just tasting delicious. There are studies underway that aim to prove the anti-aging benefits of the fruit. It is believed that the breakdown of pomegranate in the gut causes a release of urolithin A, which in turn boosts the cells’ ability to clean up after itself. Without the buildup of mitochondrial matter that happens without urolithin A, the body doesn’t age as quickly. Key Takeaways: "As we age, an important process that our cells rely on for energy slows down and begins to malfunction." Reference:
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Date:
November 19, 2016 12:49 PM
We have all felt the 2 o’ clock energy slump. What can we do to prevent it? Most people think that loading up on caffeine during the day to keep them awake is the answer. In reality, this can create a never-ending Cycle that is bad for us. The best things we can do are eat a balanced diet rich in calcium and B vitamins and get the right amount and quality of sleep. Just eating healthier is not enough, however. It is also best to eat smaller, more frequent meals to keep us powered throughout the day. Key Takeaways: "An energy-optimal meal or snack includes a mix of high-quality carbohydrates for energy with some lean protein and healthy fat for staying power." Reference:
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Date:
August 16, 2016 02:41 PM
There are a multitude of ways cancer cells can form, lets look at a few ways and discuss them. Epigenetics: A process that controls the behavior of genes. Dietary and lifestyle choices can alter the way our genes work. Exposure to toxins can cause protective genes to goto sleep and allow destructive genes to awaken all due to the way we eat and live. When this happens, disease can start. Apoptosis: known as the programed life Cycle of cells. this natural Cycle can be interrupted and when this happens, the cell does not die as intended, old and genetically damaged cells form tumors. Angiogenesis: damaged cancer cells need nutrients and oxygen to survive. Some cancers are able to form their own network of blood vessels. Cancer Stem Cells: these are super cancer cells that can remain dormant for years which eventually activate and causes cancer to recur. Cancer is a very complex disease, todays anti-cancer drugs are designed to address only one single pathway or gene with in cancer cells. Since cancer is a complex network of hundreds of genes and pathways, conventional drugs are very unlikely to be effective in the end. Since a large majority of the drugs are designed around natural plants and their function, it would stand to reason that taking the natural plant would not only be effective but have zero side effects. Fortunately, we have a plant that has been validated by thousands of scientific studies. This plant compound is called curcumin. If you are somebody you know is suffering from cancer, you should seriously consider taking curcumin or telling family members about this wonderful plant compound.
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Date:
September 22, 2015 01:00 AM
Melatonin is a hormone secreted by the pineal glands. The circadian production of melatonin is tied to the day/night Cycle. Light through the retina signals the pineal glands to suppress its production. Lack of light stimulation (at night) results to increased production of melatonin. The increased hormone production at night is associated with a good night’s sleep. According to a study, melatonin significantly reduces sleep latency and increases sleep efficiency. It has thus been used to treat insomnia. Aging and Insomnia Insomnia is commonplace among the elderly. As we age, sleep problems which include difficulty in falling asleep and maintaining the sleep are so rampant. This is so because melatonin production declines with age. With age comes the disruption of the circadian rhythms associated with the production of melatonin. To this end, melatonin supplements come handy to the elderly in maintaining a good night’s sleep. Aging and Alzheimer's Disease There is more to this hormone than a good night’s sleep and normal aging. There are evidences that melatonin suppresses Alzheimer’s disease. AD is the leading cause of dementia among individuals older than 65 years. Lack of sleep is a common symptom among AD patients and feels bad but sundowning (worsening of symptoms during evening hours) is worse. According to Netherlands Institute of Brain Research, the declining production of melatonin among the elderly not only affects the circadian rhythms but also enhances the development of Alzheimer. Melatonin as an Antioxidant Melatonin production starts to decline at age 60. This is the onset of diseases like AD which leads to increased production of free radicals in the brain. According to a review paper written in 2000, there is a lot of pathological changes among AD patients’ autopsied brains as a result of free radical activity. Melatonin carries antioxidant properties which fight the free radicals and protect the brain neurons. Melatonin Supplements Melatonin is a powerful hormone. Its function in sustaining optimal human health is crucial. New discoveries are being made on this versatile hormone. The fact that its production starts to decline at 60 only means that you need to use supplements and not fret over the onset of AD or insomnia. It is clear that besides being harmless and natural in treating insomnia, Melatonin is the most effective way of averting deleterious aging effects. References www.life-enhancement.com/magazine/article/1025-melatonin-can-reset-your-biological-clock www.quora.com/Why-do-we-sleep-less-as-we-age www.biomedgerontology.oxfordjournals.org/content/56/1/B21.full
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Date:
August 16, 2015 07:14 PM
The Krebs Cycle is a series of chemical response that helps in the production of Adenosine triphosphate (ATP) and carbon dioxide, a compound that is rich in energy. This Cycle happens with the combination of two carbon coenzymes and carbon complexes and goes through a series of changes to produce the required energy that is needed for the smooth functioning of living organism. This Cycle occurs in all the cells that use oxygen for their respiration process. Carbon dioxide has an important role since it fuels breathing and the ATP also plays a vital role as it provides cells with a required energy for synthesis of proteins from amino acid and the reproduction of deoxyribonucleic acid. These are considered essential for energy supply and for the continuation of any kind of life including human. The Krebs Cycle is known as the second phase of the aerobic respiration. Aerobic respiration is composed of three phases, Glycosis is the first phase, followed by the Krebs Cycle, and last is the Electron phase. These three stages are a series of a Cycle that all living cells must experience to produce the required energy for the smooth functioning of the mechanism of life. Why Krebs Cycle is important? Poor digestion, fatigue and lack of proper nutrition are the common complaints among the people of all ages all over the world. This complaint comes when the body does not get proper nutrition or is unable to digest food even if it's available. It leads to a chronic problem and makes most of the people suffer. But what makes them suffer? This is the listless metabolism that ultimately leads to slow Krebs Cycle function. When Krebs Cycle does not function properly, after a period of time it causes the accretion of undigested food remains in the blood vessels and also creates some other health complications such as constipation, fatigue and smoggy brain. In the long run, it can create some other health complication that is severe and sometimes life-threatening. So to avoid this situation people usually prefer to take the Krebs Cycle supplement. This supplement resolves all these issues and also makes you feel energetic. Why your body is reliant on Krebs Cycles? Krebs Cycles are important since it helps to generate energy from the food, particularly from the carbohydrate. And you can get carbohydrate from grains, cereals, fats and also from vegetable and animal sources. You can also get carbohydrates from the proteins. By definition, carbohydrates are the combination of three important things, carbon, hydrogen and oxygen and these things can be changed to glucose inside your body. Initially your body uses the carbohydrate as the foundation of glucose and then through a series of processing, the body gets the required amount of carbohydrates from the diet. And here Krebs Cycle plays an important role to generate energy from the carbohydrate. The Krebs Cycle is considered important for producing energy, it does not help you to run fast and to be active only, and it also enables your metabolic process to work efficiently. References: //www.wisegeek.org/what-is-the-krebs-Cycle.htm
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Date:
August 12, 2015 08:24 PM
Selenium is nature’s best secret. It is a nutrient that when used in the correct amounts in your food, can make huge and exciting changes. However, the body only needs small amounts of this mineral, but it has huge benefits on one’s health. It protects us against many health problems that are associated with the aging process such as osteoarthritis and cancer. A certain amount of this mineral is required in order to protect the body from deadly viruses and also to aid in healthy thyroid functioning. Selenium deficiency frequently goes untreated simply because it does not show any noticeable symptoms. If the levels of selenium are low, the thyroid will have to work extra hard to manufacture its hormones and the body will have a tough job converting those hormones to a form the cells can use. This is because selenium is a chief ingredient of the molecules necessary for the body to be able to create and use seleno-proteins (thyroid hormones). The initial stages of low selenium levels will reduce the optimal production of the thyroid hormone in the glands. If this continues the thyroid gland becomes inflamed. Eventually, this is what leads to thyroid autoimmune problems Problems that come with low selenium levels can be more serious when the levels of mineral, iodine, is low. Iodine is well known for its key role in thyroid health. Selenium is also important in aiding your body to reCycle iodine. Low selenium levels coupled with low iodine levels can lead to thyroid imbalance An enlarged thyroid is known as goiter. This is one of the serious forms of thyroid imbalance. Most individuals diagnosed with goiter usually have low iodine levels, however research has also shown that the patient also have low levels of selenium. Therefore, it is very important to treat both deficits so as to re-establish thyroid stability Doctors readily admit that there is no any specified dose of selenium required for better functioning of the thyroid. The one thing they agree on is that optimizing selenium intake aids in general health. References //www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=0CDYQFjAEahUKEwih0urP8KPHAhXHOBQKHfIrC3w&url=http%3A%2F%2Fwww.nlm.nih.gov%2Fmedlineplus%2Fdruginfo%2Fnatural%2F1003.html&ei=8GjLVaGaCsfxUPLXrOAH&usg=AFQjCNHzSWE2P10XlrjScWz9oE6KOYZFdA&bvm=bv.99804247,d.d24 //www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=0CE4QFjAIahUKEwih0urP8KPHAhXHOBQKHfIrC3w&url=http%3A%2F%2Fpatient.info%2Fdoctor%2Fselenium&ei=8GjLVaGaCsfxUPLXrOAH&usg=AFQjCNEjLPYH8bzUP0K2eUgEAAR7HIrZAg&bvm=bv.99804247,d.d24
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Date:
May 26, 2014 12:57 PM
What is 5-HTP 5-HTP (5-Hydroxytryptophan) is a compound which is produced naturally in the body via the means of the amino acid tryptophan. Even though this compound is already present in the body, researchers have found that we can benefit by having more of it. This has resulted in several supplement companies producing this compound from the seeds of an African plant known as Griffonia simplicifolia; 5-HTP can now be found in many health food and drug stores. Benefits of 5-HTP Even though there still hasn't been much research done regarding this supplement, we can still see that there are many uses for it. However, there is sufficient evidence out that shows 5-HTP is effective in treating depression and fibromyalgia, which means improved mood, reduced pain, better joint health, and better quality of sleep. To elaborate on the sleep benefits, 5-HTP increases serotonin levels which are converted into melatonin (a hormone which helps keep sleep Cycles under control) through the body. There is also some evidence to suggest that this supplement can reduce anxiety as well as help promote weight loss in obese people. So there is some great evidence to suggest that this supplement can help to improve our mood, quality of sleep, health and much more. However there is a slight downside, because of the limited amount of research done on this compound it is currently considered possibly unsafe to use. Potential side effects of 5-HTP include muscle ache/pain, heartburn, nausea, vomiting, drowsiness, stomach pain, and also a serious condition known as eosinophilia myalgia syndrome – a rare flu-like condition. Drug interactions can take place also; you should stay away from 5-HTP especially if you are taking any anti-depressant medication as these often increase serotonin levels which may result in too much serotonin in the body. In conclusion This supplement has many benefits and there has been research done to prove that it is effective in treating many problems such as insomnia, depression, fibromyalgia, anxiety, weight loss and more. However, it is recommended that you stay away from supplementing with 5-HTP because of the limited research done.
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Date:
May 07, 2014 09:08 AM
Can Glutamine Improve Nitrogen Balance in the Body? Essentials of glutamine have been found to be many. Nowadays there are commercially produced glutamine which are taken as strong anti-catabolic supplement.
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Date:
March 28, 2014 07:09 PM
The Bilberry fruit grows in Europe and North America. In Europe, it is known for its mending properties for a long time. Furthermore, Vaccinium myrtillus, is the Latin name for bilberry berries. Benefits of bilberry Bilberry discovered generally in dull cleaned fruits. It is utilized to treat loose bowels, varicose veins, and mucous film aggravation. The herb is valuable in the medicine of solidifying of the conduits (atherosclerosis) and in eye health. This herb might additionally help night vision. Throughout World War II, British Pilots consumed bilberry stick before going out on night flights. They asserted it enhanced their vision. It is accepted that the bilberry herb helps the eyes to change in accordance with progressions in light rapidly. This is one of the best benefits of bilberry and could be exceptionally valuable for one’s eyes as stated by numerous studies. In Europe, it is utilized to treat venous deficiency a condition that causes swelling and varicose veins. It further assuages torment and tingling, and it likewise. Helps battle skin ulcers on the legs. Reynaud's infection may profit from the bilberry. Reynauds reasons torment and deadness in the external limits (fingers, toes and nose) when chilly. Bilberry enhances dissemination and makes course dividers. The herb may lessen aggravation, simplicity gastro-intestinal issues, and gum issues that have been joined to coronary illness. Loose bowels and mouth injuries can profit from Bilberry too. Bilberry has solid clean properties, alleviates peptic ulcers, diabetes, fibrocystic maladies, and tormenting feminine Cycle. In view of Bilberry's makes a great free radical forager, which helps battle the cell harm that prompts untimely maturing and malady. The most noted profit that we quickly talked about is its capability to treat an extent of issues identifying with one’s eye health. Case in point, the herb ensures collagen structures in the veins of the eyes, in this way, pushing solid vessels that convey numerous crucial supplements, for example, and oxygen-rich blood to your eye muscles.
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Date:
March 16, 2014 04:33 PM
Coconut sugar and its health benefits Coconut sugar has the lowest glycemic sugar component index and is one of the best sources of vitamins and minerals that are crucial for the normal body functioning and systemic Cycle. With the same features of the normal sugar such as texture and granules, this is the best alternative to have around. The best part of this is that coconut sugar contains no artificial additives and has no artificial preservatives and this makes it the best source of healthy sugar with no whitening and bleaching.
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Date:
January 18, 2014 11:52 PM
Arginine and citrulline
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Date:
January 17, 2014 08:20 AM
Premenstrual syndrome impacts over 70% to 90% of ladies before menopause in the US and less for ladies in Southeast Asia in light of their contrast in living style and social structure. The event of premenstrual syndrome (PMS) have more than multiplied in the course of recent years because of the acknowledgement of it as a therapeutic condition that is initiated by bad eating methodology with high in soaked sustenance. Premenstrual syndrome is characterized as flawed capacity of the ovaries identified with the ladies' menstrual Cycle, it impacts a ladies' physical and enthusiastic state, and frequently meddles with every day exercises as an aftereffect of hormone change. The syndrome happens one to two prior week’s monthly Cycle and after that decays when the period begins. In this article, we will talk about how standing berry tree impacts ladies with PMS. Chaste Berry I. Definition Chaste berry tree is an exceptionally significant herb; it has been utilized as drug since old Greek for menstrual issue incorporating absence of ovulation. Today the herb is well known for treating side effects of hormone lopsidedness. II. How chaste berry tree impacts ladies with premenstrual syndrome it hard to accept that chaste beery tree holds no plant estrogen yet has been adequately utilized within treating premenstrual syndrome due to the accompanying lands 1. Iridoid Chaste beery tree holds iridoid incorporating aucubin and agnuside which are frequently intermediates in the bio combination of alkaloid. It serves to enhance invulnerable framework battling against irritation and serves to avoid muscle spam bringing about decreasing menstrual ache and spasms. 2. Androstenedione is the normal antecedent of male and female sex hormone generated by adrenal organ, chaste berry tree holds androstenedione which not just serves to tie the levels of terrible estrogen additionally equalize the levels of testosterone in the ladies figure bringing about decreasing the male example for some ladies with PMS. 3. Key oil Chaste berry tree holds cineol, pinene, castine and different substances, it serves to unwind the apprehensive framework and muscle that serves to diminish side effects of anxious pressure, for example, tension discouragement, menstrual agony and spasms brought about by over animated uterus muscle. It likewise serves to expand liver capacity for overall health. 4. Alkaloid As and alkaloid, it serves to diminish the manifestations of breast delicacy and bosom ache brought about over preparation of prolaction prior and then afterward ovulation. 5. Progesterone The chaste berry tree serves to repress if the levels of progesterone in the event that it is excessively high or raise the levels of progesterone in the event that it is excessively low, in this way, diminishing the danger of hormone awkwardness between estrogen and progesterone.
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Date:
December 22, 2013 04:58 PM
If you find that you are not able to sleep on any particular day, then you are not alone who experienced this problem because many other people are also there that face this problem on regular basis. In most of the cases this problem appears due to lack of melatonin hormone that plays an important role in regulation of sleep Cycles. Disturbed Sleep In case you disturbed your natural sleep Cycle because you traveled to some other time zone or you are in work that requires you to work in night, then it can reduce the natural production of melatonin in your body and you may find trouble in sleeping. However, melatonin supplements are available there that can help you sleep naturally. All you have to do is you need to consume it 30 minute before you go to bed. The best thing about melatonin Is that it works on almost every individual and within 30 minute of its consumption you start feeling drowsy and you find it impossible to stay awake. After that it take you in some deep sleep where you can see some vivid dream and when you wake up you find yourself completely fresh and energetic. Another great thing about melatonin is that it does not introduce any external chemical in your body to make you feel sleepy, but it does it in a natural way and that’s why you don’t even need a prescription for using it. However, it is very important that if you have any particular health problem or if you are pregnant, then it is suggested that you should consult with doctor before consuming melatonin. Other than this, it is also very important that you should consume it with guidelines only because if you take it more than suggested quantity you may feel sleepy and tired for rest of your day as well. References:
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Date:
December 20, 2013 09:04 AM
Taken from a mediterrenian tree, vitex has numerous health benefits in human life especially to women. Taken as alternative medicine, the herb can affect human body in various ways leading to diverse health benefits. These benefits include;
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2931) What Are The Health Benefits Of The Herb Motherwort?
Date:
November 29, 2013 10:40 PM
What is Motherwort Herb  Motherwort is a herb known for its properties of calming the nerves and relaxing the heart by reducing the harmful effects of stress. It is mostly used by women, but also works for men who have heart and nervous system maladies that relate to stress. It’s scientific name is “Leonurus cardiaca” and its native location is Europe and Asia. The common name comes from the fact that is has been prescribed to pregnant stressed women throughout history as a cardio tonic and nervine tonic. It strengthens and gladdens the heart thus transforming user from dull and bitter moods to relaxed, comfortable and happy ones.Benefits of Motherwort Herb The herb includes tincture that elevates a persons mood and acts as a sedative. As a result, the user gets better sleep on using heavy doses and a good energy balance when using small doses spread out through the day. When combined with linden flower and ginger tinctures it also helps to tackle postpartum depression. By acting as a galactagogue, it promotes the flow of mother’s milk and it also helps soothe the uterine before and after giving birth. For those who are not pregnant, consumption of motherwort leads to better menstrual flow as a result of the regulation of the menstrual Cycle. Women with cramps, nervousness and digestive disturbances during PMS benefit most from the consumption of this herb as tea or in other forms. As a cardio tonic, it is injected so that it can halt the clotting of blood as results to a better blood flow. Improved blood flow in the body is good for prevention of other diseases and health risks such as heart attacks and stroke. People with thyroid disease and hypoglycemia or low blood sugar tend to develop heart palpitations, but this is greatly reduced by the use of motherwort. Lastly, other useful uses of motherwort herb include the relieving of lung problems such as asthma and bronchitis. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2910) 5-HTP and how it can help promote natural sleep patterns.
Date:
November 27, 2013 07:47 AM
What is 5-hydroxytryptophan (5-HTP)?
Serotonin deficiency The production of serotonin declines with age, however it’s also important to note that, at any age serotonin production can be further compromised by stress. Low serotonin levels are commonly manifested by insomnia, depressed mood and anxiety. Good sleep. It is known that insomnia is an age-related condition. Sleep disorders are associated with very significant psychological, medical and social disturbances. Sleep deprivation can cause depression, stress and anxiety, it can also lead to fatigue, impairment of memory, immune function and mood. Nutritional supplements that contain 5-HTP, choline, melatonin and valerian root helps one to get a good sleep hence alleviating these problems. Recent research has indicated that increased serotonin levels can assist individuals suffering from chronic sleep disturbances restore healthy sleep patterns. Pathways of serotonin One of the metabolic pathways of serotonin leads to melatonin a hormone widely acknowledged for being responsible for the sleep-wake Cycle. By increasing serotonin’s level with 5-HTP, you are also increasing the melatonin levels. Melatonin is also known to improve the immune function and assist improve immunodepressions that are stress-induced. Valerian root Valerian root is a Eurasian herb that has been for long known for enhancing sleep. Valerian helps one to fall asleep and also improves the quality of sleep thus allowing one to wake up feeling refreshed. A study showed that people who used valerian were more active and alert . Choline Choline is a nutrient precursor to neurotransmitter acetylcholine, that assists to protect your sound sleep so that you are not woken up by every little murmur or cleak.Supplementing the diet with these natural substances will assist eradicate or diminish sleep disturbances and also assist reestablish healthy sleep patterns. Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2906) Did You Know Alpha Lipoic Acid Is the Best Antioxidant Out There?
Date:
November 18, 2013 07:58 AM
What is Alpha Lipoic Acid  The power of antioxidants has been being known since ancient times, primarily because these organic compounds can fight the potentially harmful substances from your organism named free radicals. Free radicals occur naturally within your body, but certain factors like pollution, improper nutrition or sedentariness can determine a substantial increase of their levels, leading to many severe diseases like cancer or diabetes. Alpha lipoic acid is an organic compound mainly known as an essential fatty acid that is present in every cell of the organism; apart from being extremely beneficial for the brain’s functions, this compound has powerful antioxidant properties that help your organism eliminate the free radicals and prevent the oxidization of the living tissues. Alpha Lipoic Acid as an Antioxidant Antioxidants are an important part of your organism’s immune system, because they create a protective barrier that can protect the organs from any potential disease; alpha lipoic acid is considered the best antioxidant, because unlike vitamins which are either water or fat soluble, this fatty acid is both fat and water soluble, which means that it can reCycle important antioxidants like vitamin C, so your organism can stay healthy for a longer time.What are the Benefits of Alpha Lipoic Acid Given that free radicals are strongly linked with an extensive variety of diseases and illnesses, as well as aging and mental disorders, the alpha lipoic acid will benefit your organism all the way around, providing you with valuable properties that should never be neglected. Over the time, the levels of this fatty acid might decrease, so you will need to take supplements that contain it in order to supply its lack. Having proper levels of alpha lipoic acid involves having a healthy brain, a young-looking skin and a well-functioning organism, so you need to make sure that your diet includes as many vitamins and minerals as possible, so you can enhance the powerful action of the alpha lipoic acid and keep your organism completely healthy. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2899) How Does Chlorella Improve Your Health?
Date:
November 04, 2013 05:06 AM
Chlorella is made by two Cycle periods that determine the total cell size and length. A timer usually runs through the G1 phase and it leads to the cell attainment prior to S phase without further growth requirement. The Cycle is consistent with increments of size control. It multiplies rapidly through photosynthesis and requires only three basic conditions to reproduce namely; water, carbon dioxide and sunlight. There are various health benefits of chlorella including; Vitamins Chlorella is rich in various types of vitamins including; A, B1, B2, B6, B12, C and E. It provides the nutrients as a whole food bundle that is way superior than manufactured formula. Minerals Chlorella is rich in magnesium that helps in improving blood sugar levels, mental health and heart health. It also contains other rich minerals including; iron, potassium and calcium. Amino Acids Chlorella is a rich protein source and it also contains important amino acids. The amino acids are used by the body for rebuilding neurotransmitters and lean tissues. Detoxification Chlorella is very effective in binding with toxic chemicals and heavy metals. The toxins are removed from the body hence bringing a positive health impact. Energy Chlorella increases the body energy. It is also very effective in elevating moods and it is way stronger than taking super food. Cancer Chlorella has amazing cancer-fighting abilities due its rich natural carotenoids that prevent oxidation. It also has the ability to nourish the system. Diabetes Chlollera helps to improve blood sugar levels and insulin over time. It can also improve insulin resistance and diabetes. Heart Disease Chlollera offers protection against heart disease by improving LDL cholesterol and triglyceride. It also has strong antioxidant properties. Obesity Chlollera has unique properties that can lower body fat. It can also improve insulin sensitivity and aid fat metabolism. Reference: www.jstor.org, www.naturalnews.com
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2874) L-glutamine as we age!
Date:
June 01, 2013 10:51 AM
Some medical conditions can lower the levels of glutamine like infections, surgery, injuries and prolonged stress, it is advisable that you take a glutamine supplements in order to boost its level in the body. L-glutamine also helps in the following health conditions;
L-glutamine reduces as we age This amino acid is mostly stored in muscles and the lungs. As muscle mass decrease with age so does the production of L-glutamine throughout the body. L-glutamine is primarily produced in the muscles, this accounts for 90% of the L-glutamine that is synthesized in the body, so aka less muscle means less glutamine. It is also produced in small amounts in the brain plus the liver but the liver more or less regulates the levels in the blood and is a large consumer of this amino acid. When glutamine levels drop, a supplement or foods high in L-glutamine should be consumed. Some studies have shown this amino acid to greatly reduce the healing time of healing for the patients who undergo surgery in the hospitals. In case one has an abdominal surgery, the hospital stay time can be reduced by providing parental nutrition of this supplement. Some of the dietary sources of L-glutamine
Small amounts of L-glutamine are also found in vegetable juices. Diets that are enriched with L-glutamine have been known to maintain cellular function as well as maintain a strong gut barrier. This suggests that this amino acid helps to protect the walls and the lining of the mucosa and gastrointestinal tract. Some of those people who may be having inflammatory bowel disease or crohn's disease might not be having enough of the it in the body. pH balancing This amino acid is a strong carbon downer, this helps in refilling the Cycle of citric acid and regulation of the acid balance in the bodies kidneys by way of producing and eliminating ammonia. More Benefits:
The List Goes On And On, have you had enough glutamine today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2845) CoQ10: What You Ought to Know about This Substance?
Date:
March 26, 2013 12:27 PM
Coenzyme Q10 or simply CoQ10 is a substance naturally present not only in a human's body but as well as with the other mammals. It plays a vital role in the production of energy. Back in the year 1957, Dr. Frederick Crane successfully used the mitochondria from the cells of a beef heart in order to locate Coenzyme Q10. But the truth of the matter is that, the substance is also present in human mitochondria. Basically, this substance has antioxidant properties which are highly beneficial in protecting the body against the free radicals present in the environment. Below are some relevant details you ought to know about this substance. Here they are: CoQ10 in Kreb's Cycle
There are a number of chemicals that the body needs to induce metabolism and one of those chemicals is CoQ10. The Kerb's Cycle is the body's mechanism to convert certain enzymes into energy. In order to achieve that, the body needs CoQ10 to facilitate the conversion of the enzymes in energy production. CoQ10 is fundamental in the Kerb's Cycle as it supports the electron transport chain in which the oxidative phosphorylation of the ADP (adenosine diphosphate) into ATP (andenosine triphosphate) needs electrons that are exactly delivered where they must be. Without CoQ10, the entire Kerb's Cycle process would certainly fail. The mitochondria of every power cells synthesize CoQ10 so the substance is present in almost all the body parts. However, the heart consumes the most CoQ10 for the reason that it has the most number of mitochondria and it keeps on working even while the body is at rest. CoQ10 Deficiency If the Kerb's Cycle fails due to CoQ10 deficiency, the person will feel exhausted and weak. But aside from that, there are other conditions that are often associated with the deficiency such as cardiovascular related diseases, Parkinson's disease and gum disease. Conversely, it doesn't necessarily mean that those diseases are brought about by CoQ10 deficiency. CoQ10 Dietary Sources The main sources of CoQ10 include fish oil, whole grains and organ meats. With a balance diet, people can get sufficient amount of coenzyme Q10. CoQ10 Supplements Aging is an inevitable process and it can affect the synthesis of CoQ10. As humans grow older, the production of the coenzyme Q10 gradually decreases. It was mentioned earlier some of the foods that are incredibly beneficial in maintaining ample amount of CoQ10 in the body. But people who do not really include those foods in their diet should not worry for there are now food supplements that contain CoQ10. Some medications like cholesterol meds can prevent the body from using CoQ10, this is when it is essential for one to take a supplement. Fortunately, with the advent of medical researches and innovative technology in drug manufacturing, CoQ10 can now be ingested into one single tablet, soft gel capsule, hard shell capsule or an oral spray. CoQ10 is a fat-soluble substance so taking it along with foods is highly encouraged. Who Takes CoQ10 Supplement? Children under 18 years old are not allowed to take CoQ10 supplements unless prescribed by the doctor. For adults at the age of 19 or older, the recommended dosage in 30 - 600 mg daily. Higher dosage may be taken for special conditions.
Humans need energy in order to carry out all the tasks. Therefore, CoQ10 must be taken daily, whether from foods or supplements, so the body has the energy to move. Have you had your CoQ10 Today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2834) Can Melatonin Be Used For Fibromyalgia?
Date:
December 28, 2012 04:19 PM
Fibromyalgia is a condition that may be very frustrating and has no known cure currently. Due to its complexity and also the number of symptoms that occur during an infection with fibromyalgia, one may be moody, anxious, depressed or irritable. Melatonin, a natural hormone which controls sleep patterns, can help relieve some symptoms of fibromyalgia and promote one's feelings of well-being. About Melatonin Melatonin hormone is produced by the brain's pineal gland. It is majorly responsible for controlling the sleep-wake Cycle; called the circadian rhythm. The secretion of melatonin is influenced by exposure to light. Whenever it gets dark, melatonin production rises. Conversely, during exposure to sunlight, the production of melatonin is lowered. Several people employ the use of melatonin supplements to promote symptoms of insomnia, since it can aid to reset one's body clock and even make it easier to fall and stay asleep. How melanin treats Fibromyalgia Disturbances of sleep and the frequent disruption of circadian rhythms occur during fibromyalgia. Melatonin has always been proven to synchronize the circadian rhythms and promote the quality of sleep. Excess damage by free-radicals is quite common in fibromyalgia patients. Melatonin as well as its metabolites have been discovered to be potent scavengers of free radicals and indirect antioxidants. Elevated Nitric Oxide In Patients Some studies have shown that synthesis of nitric oxide is elevated in fibromyalgia patients. Melatonin acts as a potent inhibitor of a rate-limiting enzyme in the production of nitric oxide. Depression is at times a symptom or maybe an overlapping fibromyalgia condition. Melatonin As An Antidepressant: Melatonin has also been proven to be an antidepressant. There is a component of melatonin that has been synthesized in the pharmaceutical industry and is now being enhanced as an antidepressant. Lyrica, antiepileptic drugs, have been proven to be effective in the treatment of fibromyalgia. Melatonin has been found to work as an antiepileptic too.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2790) Melatonin Overdose
Date:
December 27, 2012 01:59 PM
Melatonin is a powerful antioxidant/hormone secreted by a small endocrine gland in the human brain. The hormone is responsible for sleep-wake Cycle modulation and fine tuning of your body's "internal clock". In other words: when it gets dark, your pineal gland increases melatonin production, which induces drowsiness and makes you sleepy. When light conditions change (e.g. daytime), your body decreases melatonin production. If you expose yourself to an intense source of light during the night, or keep spending time in a dark environment during the day, you can confuse your body and disrupt melatonin production. The hormone was also observed to affect the production and the discharge rate of female sex hormones.
As one gets older, his pineal gland produces less and less melatonin, which leads to a conclusion that melatonin is age dependent (children have the highest concentration of melatonin). The fact that our body produces melatonin to "sedate" itself when the sun goes down, implied that the hormone could be used to help people suffering from sleeping disorders, desynchronosis (jet lag) or similar conditions. This served as a basis to study and use positive health effects of the hormone. Melatonin is not a miracle-cure, but it CAN improve the sleep quality of insomniacs, women in menopause, benzodiazepine (valium) withdrawal patients and people who suffer from ADHD. Melatonin also improves the effectiveness of chemotherapeutic agents in breast cancer treatments and increases the chance of survival in prostate cancer patients.
If you are a healthy middle-aged person, your body will produce between 5-25 micrograms of melatonin per night (80 times less than a single melatonin capsule). This is a good indicator of recommended dosage. In fact, you should start with 0.1 - 03 mg per night, an hour before bedtime. If that doesn't help, you may increase the dosage up to 10mg a day. However, do not exceed 10 mg per night before consulting your doctor, as that may cause an overdose. Anything above 10 mg is risky without a professional guidance . If you consider the fact that you can overdose even with a sufficient amount of vitamins, melatonin is not an exception, and should be used with caution. Typical overdose symptoms include drowsiness, upset stomach, headache, confusion, lethargy, psychotic thinking, tremors, seizures and liver issues. If you experience multiple symptoms at the same time, you should visit your doctor as soon as possible.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2783) Can Melatonin Increase Prolactin?
Date:
December 22, 2012 11:28 AM
What Is Melatonin? Melatonin chemically known as N-acetyl-5-methoxytryptamine is a naturally occurring compound normally found in microbes, plants and animals. Many of the biological effects that are associated with this product are usually produced via activation of the melatonin receptors. However, there are others which are as a result of its powerful and pervasive antioxidant nature. Melatonin and Sleep Melatonin also plays a vital role in maintaining natural Cycle of wakefulness and sleep. There are some controversies over whether melatonin can increase prolactin or not. Can Melatonin Increase Prolactin? Studies that have been conducted recently by medical experts have shown that melatonin can cause an increase in the level of prolactin. Prolactin refers to a hormone which usually plays a vital role in regulating menstrual Cycle and in producing milk. It is thus advisable that women who normally experience mood changes or who are in depression related to menstruation should avoid it. In conclusion, it is my sincere hope that the question on if melatonin can increase prolactin has been answered.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2772) Benefits of wild yam to women
Date:
December 21, 2012 11:17 AM
Wild yam which is also known as Dioscorea villosa has been used for a very long time to help women deal with various health issues especially those associated with menstrual Cycles. There are various forms in which this herb can be taken for example capsules and creams. Wild yam is so popular among women due to the progesterone properties that it carries. This herb contains an ingredient diosgenin which is converted in the body to produce progesterone. Progesterone plays a very crucial role in a woman's body. Some of the roles include;
This hormone is known to produce mucus which protects the vaginal area from infections. When there are higher levels of progesterone in the blood, women will experience a spike in their libido. Supplementing with progesterone is mostly beneficial after menopause when most women experience reduced intimate desires. Progesterone plays a major role during menstruation. It prepares the endothelium for fertilization. If fertilization does not happen, the levels of progesterone will fall down resulting in menstrual periods. Wild yam can help easy PMS Women who experience painful cramps after menstruation could really benefit from progesterone supplements. With its antispasmotic properties, the progesterone may help to relax the muscles hence reducing the amount of pain experienced. Progesterone may also help to ease labor pains. Wild Yam Is A Natural Progesterone Women who are undergoing menopause may also want to use wild yam. This herb helps to restore hormonal balance thus ensuring that a woman does not face the usual hot flashes and sweating at night. Having hormonal imbalances could really deny you the comfort in life. Hormones such as progesterone which are very crucial for a woman's body processes should always be checked. Progesterone supplements are most appropriate when you are experiencing progesterone deficit. Wild yam supplement comes in the form of capsules or creams. If it comes combined with other ingredients, ensure that all the ingredients are safe for your body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2762) Can Melatonin Help Me Sleep?
Date:
December 20, 2012 12:22 PM
What is melatonin? Melatonin can be described as a hormone generated in the pineal gland found in the brain. It controls the body circadian rhythms such as sleep-wake Cycle. The levels of melatonin in the blood increase before you fall asleep due to darkness (Lack of sunshine). Where to find melatonin Melatonin occurs naturally in humans and plants. Natural melatonin quantity produced decrease with age. Older people produce very little quantities of it. Current Sources It is a synthetic medication that is produced in the laboratories. It is available in pill or liquid forms. The pills can be put in the cheek, underneath the tongue or swallowed. This permits direct absorption in the body. Melatonin supplements are available in health food shops. Food Sources It is also found in foods, in small quantities, such as milk, chicken meat, turkey, and peanuts but in small quantities. Melatonin and sleep Melatonin does not work for every kind of insomnia or sleeping disorders. Your body needs to be ready for sleep for melatonin to be effective. It is safe to use melatonin supplements in low doses long term. Melatonin treats insomnia, autism in children, and as a sleep reliever after withdrawal from benzodiazepine drugs use. It is also very significant for changing sleep/wake patterns for people who work schedules changes regularly. It can also be used to calm individuals before anesthesia is administered for surgery purposes. The body has an internal clock that regulates sleeping Cycle and waking hours. The body clock regulates the amount of melatonin produced each day. Melatonin production is affected by light.
For effective treatment of Cycle sleep, make sure you take the supplements at the appropriate time of the day (Night time). Use the right method and dosage for it to be helpful. Consuming the sleep supplement at the inappropriate time of the day can lead to biological clock reset. It is essential to understand the right quantity, time of taking and its effectiveness. Taking 1-10mg of melatonin every day restores the pace in people experiencing insomnia synchronizing them to duration of 1day. Melatonin helps enhance sleep. It enhances sleepiness feeling and can intensify the duration of sleep. This supplement has been applied successfully for improving sleep in healthy people and also decreasing jet lag feeling during travels. Remember to consult a physician if you are experiencing sleep issues. Give melatonin a try start with lower doses like 1 mg before bed time and gradually increase till it becomes effective.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2757) Health benefits of triphala
Date:
August 07, 2012 08:22 AM
Triphala Owing to the unhealthy food habits that people follow, there is hardly anyone who does not suffer from stomach problems like acidity, constipation, pain in abdomen and loss in appetite. These ailments can lead to various other problems like fatigue, hypertension, poor eyesight, skin ailments and headache. If you have tried various antibiotics, medicines and diets without getting any desired relief, it is time you try out triphala. It is an Indian mixture of herbs which can bring about great positive changes. Triphala is a Sanskrit term meaning ‘three fruits'. Triphala contains Bibhitaki (Terminalia belliricia), Amalaki (Emblica officinalis) and Haritaki (Terminalia chebula). It is important for you to know the benefits that each of these ingredients offer. Bibhitaki (Terminalia belliricia)Bibhitaki is an internal cleanser, which helps remove harmful toxins, and gets your body rid of excess fats. It purifies your blood and helps control hemorrhage.It strengthens the hair roots and also improves hair texture and color. It is anti bacterial and anti viral in nature. It improves eyesight and betters voice quality. Amalaki (Emblica officinalis)It is an antioxidant and helps your body get rid of harmful toxins.Amlaki is very rich in vitamin C which is helpful in building immunity. It nourishes and strengthens respiratory tract and lungs by removing mucous out of the lungs.It increases fertility in both females and males and also helps maintain a good reproductive health by regulating menstrual Cycle. It offers a healthy glow to the skin by working as detox, which helps in formation of fresh tissues. Haritaki (Terminalia chebula)Haritaki has five rasas or tastes, which are salty, sour, bitter, pungent and sweet. It strengthens the sensory organs and stimulates the functioning of the digestive system.It is a great cure against anemia, piles, gallstone and diarrhea. It is helps fight cough, asthma, headache and fever. It helps regulate blood pressure and prevents heart diseases. These three herbs when combined form a great drug, the benefits of which are mentioned below. Benefits for heart It helps maintain cholesterol levels, reducing the risk of heart problems. It limits the formation of low density lipoprotein in the body and helps in the formation of high density lipoprotein. It regularizes the heart rate and is thus beneficial for heart patients. It helps generate red blood cells and is thus helpful for anemia patients. Benefits for stomach It acts as a natural appetizer and helps in proper digestion thus benefiting the digestive systemIt helps evacuate the bowel and throws harmful toxins out of the body.It relives your body of harmful gases thus curing acidity,It is helpful in curing stomach ulcers. It acts as an internal cleanser for the body. Benefits for skin and eyes It controls the amount of external radicals in the blood, which helps reduce skin disorders and infections. It improves blood quality and thus benefits the skin.Its antioxidant property helps delay aging. It improves eyesight by strengthening the muscles around the eyes. It helps cure eye problems like glaucoma, cataracts and conjunctivitis.It can be used to wash eyes to get rid of redness. For weight loss Triphala is very helpful in treating obesity. Since it helps in proper functioning of the digestive system, it helps reduce body fat.It secretes bile juices which is beneficial for the liver and is needed for burning fats. By reducing excessive water content of tissues it helps in weight loss.It also cuts down hunger pangs. Triphala has endless health benefits to offer, no wonder, more and more people are opting for the same.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2671) How does 5-HTP Help the Brain?
Date:
May 28, 2012 08:17 AM
5-HTP 5-HTP is the abbreviation of 5-Hydroxytryptophan, an amino acid that converts tryptophan into serotonin and melatonin. Serotonin is a neurotransmitter that helps with the regulation of sleep, mood and appetite, and it is found in the stomach or the CNS. 5-HTP is mainly obtained from animal products especially red meats and eggs. Fish and dairy products are also rich in this amino acid. Vegetarians get this compound from pumpkin seeds, oats, potatoes, peanuts and dried dates. Due to its ability to regulate the amount of serotonin and melatonin in your body, 5-HTP regulates the functioning of your brain. The following are the health benefits of this compound: It fixes anxiety Anxiety and panic disorders are some of the most popular mental disorders that can be cured using 5-HTP. These two illnesses occur when your body experiences a deficiency of serotonin. Therefore, taking supplements of this amino acid reduces your chances of developing any or both of these conditions. It treats insomnia Insomnia is a problem that affects the quality of your sleep. Sleep is normally regulated by your brain. Every night, your brain releases receptors that lead to the five stages of a sleep Cycle. If your brain fails to release the appropriate receptors, you cannot enjoy a complete sleep Cycle. In addition, Melatonin is the hormone that induces sleep and therefore its absence leads to poor sleep quality. The production of sufficient melatonin therefore boosts the quality of your sleep and helps with the treatment of insomnia. It helps relieve the symptoms of depression Your mood is controlled by the neurotransmitter serotonin. The absence of this neurotransmitter leads to the development of a depressed mood. However, the availability of 5-HTP in your body leads to the production of sufficient serotonin thus restoring your happiness. It also treats eating disorders especially among young children Your brain controls your levels of appetite. Serotonin is specifically in charge of this function, and therefore its deficiency in your body leads to a disruption in your appetite mechanism. Most people who have this problem often tend to eat lots of sweet foods that are rich in empty calories, high carb and junk food. This often leads to obesity and overweight. However, taking 5-HTP supplements restores your appetite mechanism thus protecting you from eating disorders and subsequent complications such as obesity. It is a natural pain killer 5-HTP enhances the production of endorphins, thus helping your body overcome pain and migraines. Chronic headache is often associated with low levels of serotonin, and this can be reversed by taking sufficient 5-HTP. Serotonin has a calming and soothing effect on the central nervous system, and therefore the sufficient release of this neurotransmitter helps ease pain on the head. 5-HTP helps relieve the symptoms of fibromyalgia Fibromyalgia is often accompanied by chronic pains and aches that can be relieved by taking sufficient supply of 5-HTP. This is because this amino acid helps with the secretion of serotonin, which helps ease such pains and aches. It is therefore important for you to ensure that you have sufficient supply of 5-HTP in order to enhance the functioning of your brain.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2649) How Does Melatonin Improve Sleep?
Date:
April 06, 2012 07:59 AM
Melatonin And Sleep Sleep is a natural part of human life and an activity that any living human being has to indulge in. In fact, even the mentally ill who are believed to be able to go without sleep are brought down by it at one point or another. Contrary to what most people believe that sleep only has to take place at night, research has established that the Cycle of sleep keeps alternating and does that sleep does not entirely have to take place at night. It can even occur successfully during the day. However, exposure to darkness and light regulates sleep in humans. It is said that exposure to light stimulates hormonal activity to make a person feel sleepy or awake. The Brain And Sleep In the brain, there is a nerve center called the Supra-Chiasmatic Nucleus (SCN) that works by starting signals to the other sections of the brain by controlling hormones, temperature of the body and other functions that also play numerous roles in making people to feel either sleepy or wide awake. The SCN works in the notion that once the body is exposed to first light every day, the clock starts to conduct various activities that will ensure that the person is awake like raising the temperature of the body and also the release of certain hormones that help in stimulating the body such as Cortisol. The clock also delays production hormones such as Melatonin that is associated with the onset of sleep until that time when darkness shall arrive. Melatonin Is A Hormone In The body Melatonin is a hormone that is part of the sleep and wake Cycle of humans. However, it has to be noted that taking too much of the pill does not make one to sleep faster or even stay asleep for a longer period of time. The first step that everyone having sleeping problems should take is to consult a doctor or a physician. This will help in making the person fully understand the reason for the sleeping problem rather than going for Melatonin straight away. Melatonin is natural hormone that is made by a gland in the body known as pineal gland. The gland is shaped like a pea and found in the brain. The gland is only active during sunset when it is dark. When active, it stirs the production of sleep and wake Cycle hormone by the SCN. As a result of this, the blood Melatonin level sharply rises and one begins to feel less alert thus prompting sleep. Conditions That Slow Down Melatonin Production Bright light also inhibits formation of Melatonin. However, for the person to be able to fall asleep, they will have to get to a darker surrounding to enable the formation of Melatonin that is sufficient to cause sleep. The hormone is naturally contained in certain foods and the reason it is sometimes sold as a dietary supplement. Taking a typical dose of Melatonin pill is able to elevate the blood melatonin levels up to 20 times normal. To be able to solve your sleep problem using melatonin, always use the correct dose at the right time of the day.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2629) What Is L-Carnosine And What Does It Do?
Date:
March 30, 2012 08:28 AM
What Is L-Carnosine L-Carnosine is basically a combination of 2 vital amino acids-L-histidine and beta-alanine. It is naturally present in the body, mainly in the muscle, and in many animals too. Carnosine can be broken down easily into the two amino acids, but it is good to know that these amino acids work much better when combined to form L-Carnosine. L-Carnosine has the remarkable ability to revitalize, that is, to make older cells younger and lengthen their life Cycle. This compound is commercially available and is the only one that has the rare and distinctive ability to rejuvenate cells. What does L-Carnosine do? In simple language, L-carnosine is able to transform itself into so many compounds with each performing or enhancing a number of crucial body functions such as: May bind to dangerous metal compounds to make them inactive. Turning the resultant metal compound/carnosine into useful antioxidants which in turn can be anti-ulcer agents Protecting and stabilizing cell membranes, keeping cells safe from dangerous free radicals Protecting healthy cells from damage caused by radiation Fighting allergies Enhances blood flow to the brain Acts like a neurotransmitter, helping messages move from one nerve to the other. This helps fight dementia, as in Alzheimer's disease and Parkinson's disease, and boost memory. Blocks guanylate cyclase activation, an enzyme associated with cancer, migraine, asthma, and septic shock. Special derivatives of carnosine can help get rid of the accumulation of sugar compounds and abnormal protein in the eye. A variety of these compounds may cause glaucoma, cataracts, and macular degeneration. Carnosine works like a catalyst to boost the work of so many other compounds and nutrients. Benefits of using L-carnosine Although L-carnosine benefits haven't been extensively researched, according to initial studies it may help in: Dealing with complications related to cataracts, diabetes, neuropathy, and kidney failure. It may also help in slowing down aging in skin, minimizing wrinkles as well as breakdown of elasticity in skin. It can help to prevent joint inflammation, atherosclerosis, and formation of cataract. Carnosine has been known to prevent and reduce cell damage occasioned by beta amyloid-the substance found in Alzheimer's patent's brain. Additionally, carnosine appears able to help get rid of the helicobacter pylori bacterium, the organism associated with stomach cancer and peptic cancer. Therefore, it can significantly help protect and heal both peptic and gastric ulcers. Other possible L-carnosine benefits Increase muscle endurance and strength Improves heart function Speeds healing of wound A powerful antioxidant that can deal with even the worst free radicals Reduces inflammation and boosts immunity It helps pull out or chelate some heavy metals from your body May help autistic children Act as anti-cancer agent in the body Stabilizes cell membranes and slows down lipid peroxidation to protect the process of aging of the brain L-carnosine can help in preventing or even treating age-related conditions like: Cell aging/cellular senescence Neurological degeneration Cross-linking of eye lens Build up of damaged proteins Brain circulatory deficit Muscle atrophy Cross-linking of collagen in the skin DNA chromosome damage LDL cholesterol oxidation Formation of AGEs i.e. advanced glycation end-products. What is stopping you from taking L-Carnosine today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2623) What Are The Health Benefits Of Progesterone Cream To Women?
Date:
March 11, 2012 10:24 PM
Progesterone Cream and its Benefits to Women Progesterone is a hormone produced by male and female bodies as well, although in females it is much more present as it helps to regulate the reproduction Cycle. It mainly helps to balance the levels of estrogen within the body and the absence of enough progesterone has been linked to an increased chance of having breast cancer as well as osteoporosis. Unfortunately, after the menopause the production of progesterone is basically stopped in females, which as you can imagine can eventually lead to various health problems, including the ones mentioned above. Fortunately though, you can do more than simply sit there and endure it as there is a natural and painless remedy to the situation: progesterone cream. What Is It? Progesterone cream is basically what it sounds like, being a cream which contains concentrated amounts of progesterone that have been integrated into a solution which your skin can absorb. As far as intake methods go, this is by far the most painless one as all you need to do is simply rub some cream on various parts of your skin. In most cases, the progesterone cream you will be using is going to be an extremely soluble fat, meaning it will be absorbed by parts of your body such as the cheeks, the neck, the buttocks and the breasts. Hormone Balance and Progesterone As mentioned before, progesterone helps to manage estrogen levels in the system which plays a critical role in keeping people healthy, especially when it comes to women. Using a progesterone cream will improve your life in many ways, with the most obvious one being your libido. While most of you may already know this, the key to having the best possible libido is to have your hormones in perfect health and balance, which is precisely what progesterone does. Apart from that, an increased intake of progesterone in your body will also help your immune system and shield you from various heart and bone-related illnesses. While it is a cream you must take care to only use it within your prescribed dosage seeing as how having too much progesterone in your system will also prove to be detrimental for your health. And by detrimental I mean it will cause a hormonal imbalance which is definitely not what you are looking to do as that generally results in the weakening of your system, allowing illnesses to set in. More precisely scientists have actually demonstrated that have an excess of progesterone in your body is extremely nefarious for your heart. However, when used to properly balance estrogen levels, a progesterone cream has various health-related benefits, most of which have already been mentioned above. All in all, if you are expecting to or have recently hit your menopause then it is highly recommended that you take progesterone daily.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2608) What Are The Health Benefits Of Rhodiola Rosea?
Date:
February 26, 2012 07:02 PM
Rhodiola Rosea: Rhodiola rosea is medicinal herb that has many beneficial health effects on humans. It grows in the cold regions of the world like Europe, Central Asia and Arctic region. The phytochemicals present in this medicinal plant are good antioxidants and they are quercetin, chlorogenic acid, gallic acid and proanthocyanidins. It also consists of essential polyphenols namely rosiridin, rhodioniside and rhodiolin in the extracts of Rhodiola. These substances are the active ingredients of this herb and helps in improving the overall health of the body. The extracts of this plant can be taken in the form of tea, pills or liquid form and must be taken after prescription by medicinal health expert. Some of the health benefits of Rhodiola rosea plant are explained as follows Stabilize the Nervous system: This nature gifted herb is very helpful to stabilize the levels of neurotransmitters in our brain and thereby increase the levels of tryptophan, dopamine and norenephrine in our body naturally. Thereby, improve the neuro-chemical reactions inside the body.A Good Anti-oxidant: It acts as a good antioxidant and also protects our nervous system. It helps to overcome the damage caused to nervous system by eliminating the free radicals present in our body. Treat Depression: It is known though a scientific research that Rhodiola rosea gave good results to treat mild and moderate depression on people of age group from 18 years to 70 years. The prescribed dosage to get the complete health benefit is 340 mg to 680 mg per day. SHR-5, the extract of this plant enhances the mental performance and also helps the person to concentrate on healthier subjects. This medicinal herb can also be used along with other anti-depressant drugs as it has the synergistic effect. Regular intake of the plant's extract according to the prescribed dosage by expert doctor reduced the symptoms of fatigue and helped them improve their concentration power. This herb is being used in cold counties like Scandinavia and Russia to overcome the stressful life and chill climate. Improves the Overall Health: This medicinal herb is known to enhance the immune system of a person and also improve the overall health. It helps in preventing the side-effects of stress and improve the physical activity, enhance the mood, appetite, estrus Cycle, reduce fatigue etc. It also helps to overcome stress, anxiety, anemia, hormonal imbalance cardiovascular diseases, and neurological disorders of a person. It is also known to decrease the time needed for recovery after any strenuous muscular activity. Treat Insomnia: It is also being used to treat Insomnia and has given good results. Sleeplessness can be cured effectively with this herb without any side effects. Pregnant women and breastfeeding mothers should not take this medicinal herb as it has some side effects on them. Always consult your medicinal health expert before taking the extracts of this herb and take the correct dosage.It is known to maintain creatine phosphate at high levels and this is especially useful for athletes to maintain their stamina levels. Rhodiola rosea is also used to overcome the side effects of radiation therapy and chemotherapy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2594) Deer Antler Benefit for Vitality and Improved Health 
Date:
February 06, 2012 04:06 PM
When men want to increase their strength and their vitality in doing daily activities, they can always consume deer antler extract, which is believed to be able to help the body system gain more power. Not many people may realize that using such extract can really improve their vitality and their strength. Some people may consider it as a hoax, but there're several proofs and evidences that show this particular extract can really improve the testosterone level in men. Originally known as a part of traditional and ancient medical treatment, this deer antler extract can be consumed to improve the testosterone level as well as the overall performance of the body system. When men consume the extract, they're believed to be able to experience: - Development in body endurance, lean body ability, and muscle mass. - Quicker recovery period from any physical injury. - Better sexual functioning - this benefit can apply to men and women. - Higher and better energy level and vitality. - Improved and better immune system. - Aging delay, since the skin and the hair will have better Cycle growth that make them look younger - Stronger nutritional support for the entire body system, especially the joints and the bones. Deer antler extract isn't only helpful in those areas, but it also helps reducing stress level. Based on a medical observation done by Dr. Fenessy from New Zealand, this extract was quite beneficial when used in previous Russian study. The medical patients who had undergone gastrointestinal tumor surgeries were taking the extract prior to their operation. And they had shown quite amazing result; their stress level was decreasing. There was also another research that measured the mental ability of the students. They had been given the extract before taking math test. Based on the result, their mental ability was improving. Based on the study done in Russia and New Zealand, the Western medical societies are starting to do researches concerning the usage of the extract as vitamins so the consumer can really achieve the medical and optimal benefits. So, what's the relation of deer antler extract and the testosterone? Medical experts believe that the antler can increase the production of the androsternedione. The androsternedione is a natural steroid that is actually produced by the body. This substance is produced in the gonads and adrenal glands, which then changed into testosterone inside the liver. So, when people consume the antler, automatically, they will produce more androsternedione. When more androsternedione is produced, naturally the number of testosterone will also increase. Testosterone itself is also responsible for the improvement of metabolism and body's recovery ability. This typical extract is mostly available in powdery form, although it's possible that it's also available in liquid form. People can always boil it, mix it with warm water, mix it with other herbs, or dilute it with alcohol. They can: - Combine it with ginseng for improved energy - Mix it with 40% of alcohol for tonic supplement - Combine it with Drynaria or Dipsacus for kidney treatment - Mix it with Dang Gui for strengthening the blood It's advisable that they should make a medium sized boil and then store it. They only need to consume the deer antler combination per ounce a day until the storage container is empty.
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If you are a man, there is a good chance that you are interested in building muscle and improving your quality of life. And if that is the case, you may be wondering about IGF-1 benefits for men. What is IGF-1? How can it help you? In this blog post, we will discuss the benefits of IGF-1 for men and how to maximize them! 
What is a bilberry
Coconut sugar is extracted from young coconut tree flowers and provides the best natural organic sugar and a source of the best alternative to sugar cane based sweeteners and the best solution for people suffering from sugar related conditions such as blood sugar diabetes and heart diseases. Further, coconut sugar is known to reduce incidences of obesity and the bring down the levels of cholesterol in the blood. 
Are popular amino acids among individuals who are enthusiastic about athletic performance and muscle development. L-Arginine and L-Citrulline are marketed as amino acid supplements that are especially useful for athletes who need an additional biochemical support for enhanced muscular energy and growth of muscle fibers. Bodybuilders and weightlifters are especially passionate about amino acid supplements because it helps them break through muscle development stagnation and reach more difficult goals in terms of muscle size or weight lifting potential.
Premestrual Syndrome (PMS)
Melatonin
Health Benefits of Vitex
5-hydroxytryptophan (5-HTP) is a substance derived from Griffonia simplicifolia’s seed pods. In the human body, 5-hydroxytryptophan is an immediate nutrient precursor to neurotransmitter serotonin. This implies that 5-HTP directly converts into serotonin in human brain. Serotonin plays very many essential functions such as; a role in appetite, learning, sleep, memory, temperature regulation, cardiovascular function, endocrine regulation, sexual behavior, mood and muscle contraction.
What is Chlorella 
Glutamine is one of the most abundant amino acids in the body. The body is capable of making enough of glutamine for its own regular needs although at times of extreme stress and age, the body may need more. Glutamine has some great importance (aka. body detox) as it is used by the body to remove excess ammonia which is a waste product the body produces everyday. It also acts as an immune system function booster as well as helping the brain to function and aiding in digestion. 
