Date: July 01, 2008 05:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Rescue From High Cholesterol

Cholesterol is an unsaturated waxy solid that is manufactured in the body and has important functions relative to cell membrane management. It is also known to help produce bile to digest fats and can help in metabolizing fat-soluble vitamins. Cholesterol is both made in tissue membranes and derived through the diet. This is where the basis of good and bad cholesterol comes into play. Cholesterol that is made in tissue membranes is transported by high-density lipoprotein (HDL), which delivers the cholesterol to the liver. HDL is thought to remove cholesterol from arteries and delivers it back to the liver for processing. Increased levels of HDL have also been deemed as protective against heart disease. Low-density lipoprotein (LDL), on the other hand, is dietary cholesterol that is transported and carries cholesterol from the liver to tissue membranes.

This factor is not what makes LDL cholesterol bad, instead it is the amount of cholesterol in the wrong place at the wrong time. Large amounts of cholesterol and LDL in the arteries can lead to plaques that gradually damage arteries over time, which leads to heart attack, stroke, or some other type of heart and vascular diseases. Because of these reasons, cholesterol management for heart and vascular health focuses on lowering LDL cholesterol. What is often overlooked is the value of raising HDL cholesterol levels, which can improve removal of cholesterol from dangerous locations in the arteries.

The diet greatly influences health, and by addressing Macro and micro nutrients, cholesterol health can be greatly reduced. Macro nutrients that affect cholesterol include fiber, protein, and fats. Micro nutrients are things such as vitamins and minerals, especially those that have potent antioxidant mechanisms, which can affect lipid peroxidation. Fiber, which has long been recommended by the American Heart association (AHA), lowers total and LDL cholesterol levels, while raising HDL levels. Although fiber is straightforward, the trick with protein is to always find a good source that does not have saturated fat and cholesterol that can negate its benefits. Although whey protein is animal-based, it has been shown to lower LDL cholesterol. However, many people have looked to soy to provide cholesterol-managing protein.

When it comes to natural products, there are a few key nutrients that can help with cholesterol management. Among these are DHA, EPA, Omega-3s and 6s, Vitamin E, Vitamin B, and Niacin. Limiting oxidative stress and lipid peroxidation are also important components of cholesterol management. Although micro nutrients give a good level of protection from oxidation, a large amount of antioxidant fighters comes from botanicals, flavonoids, and carotenoids. Some flavonoids that can help with cholesterol care include cocoa, tea, and fruit.

Citrus bioflavonoids also help with antioxidant management, especially when they are combined with vitamin E. Fruits such as pomegranate and grape seed extract help to limit LDL oxidation. Botanicals such as garlic, which contain antioxidant constituents help to lower total and LDL cholesterol while still maintaining HDL levels. Other suggestions to help maintain healthy cholesterol levels include pine bark extract as well as some types of algae.

Whether you’re attempting to use just one or many of these approaches to battle cholesterol levels, there are many well-researched ways to both lower the bad and raise the good cholesterol.

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Date: April 28, 2008 02:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cherry Fruit Extract

Cherry fruit extract contains organic compounds known as flavanoids, which is a form of phytochemical frequently found in highly colored fruits and vegetables. If you eat a fruit such as pomegranate, blueberry, blackberry or cherry, or if you eat red peppers, aubergines and broccoli, you are eating foods that are rich in flavanoids.

Such foods provide you with remarkable health benefits that your ancestors knew about but did not understand. They ate these highly colored foods because they knew they helped prevent certain medical conditions, and to help others get well faster. They knew nothing about phytochemicals – chemicals contained in plants – or flavanoids, but knew about the results of eating them.

In fact, flavanoids are very powerful antioxidants and anti-inflammatories, and each of these require more detailed explanation since between them, oxidants and inflammation are responsible for most of the non-infectious common ailments of the human body. First, let’s have a look at antioxidants.

In chemical terms oxidation is the removal of an electron from an atom or molecule. There are species within your body known as free radicals whose sole purpose in their short life is to steal an electron from the nearest molecule to them. This is almost instantaneous, and most free radicals are very short lived. The concept of free radicals roaming your body and your bloodstream waiting to pounce on the first unwary molecule is a fairy tale. In fact the vast majority react as soon as they are formed.

When they do react, they remove an electron from a stable molecule, render it unstable and thus destroy it. If that molecule is part of a cell, and enough of them are robbed of their electrons, then the cell is destroyed. One result in visible terms is wrinkling of your skin, as your skin cells become destroyed, and hence you age quicker. In terms that you are not immediately aware of, oxidation can lead to many unwanted changes in your body.

For example, the low density lipids, that carry the cholesterol in your blood to areas of the body where it is needed, are oxidized by free radicals which causes the LDL to deposit along with their cholesterol on the walls of your arteries as a layer of plaque. Eventually that will build up to constrict the artery and cause a condition known as atherosclerosis – the arteries become blocked, and you can suffer from heart attacks and strokes.

These free radicals are formed by the normal metabolism of the body when energy is created in the cell mitochondria, by pollutants such as pesticides, cigarette smoke and traffic fumes, and by radiation such as excessive exposure to the UV radiation in sunlight.

Flavanoids, contained in cherry fruit extract, are antioxidants, which prevent this oxidation of body cells from taking place. They do so by being in the right place at the right time. If a flavanoid molecule is close to a free radical when it is generated, then the antioxidant will reduce the free radical and neutralize it.

If you eat a lot of cherries, or drink cherry fruit extract, you will be consuming a massive amount of flavanoids molecules that are ready and willing to destroy these free radicals. However, that is not all that flavanoids do. They are also, as has already been stated, anti-inflammatories.

The inflammatory response is the reaction of the body to a foreign presence such as bacteria. The tissues around the infected area receive an increased blood supply, and the cell walls produce gaps allowing the large immune system blood cells, or Macrophages, to pass through. The temperature around the area increases due to the concentration of blood, and this itself is controlled by the body since bacteria die off after a certain body temperature has been reached, hence the reason for fever in the immune response.

The area swells up due to the concentration of fluid and protein, and becomes painful due to pressure on nerve endings. Anti-inflammatories, such as the flavanoids, work to relieve the symptoms of inflammation without interfering with the way the immune system deals with infection.

Many inflammatory conditions occur without any apparent reason, and while anti-inflammatories might not be used to suppress the immune system, it is used in such conditions as rheumatoid arthritis where the inflammation is a mis-firing of the immune system. Cherry fruit extract can be used to alleviate many similar conditions such as gout, and osteoarthritis where its use is well known and recorded.

It can also be used to help reduce the effects of atherosclerosis through its anti-oxidant properties, and cherries contain, not only a good supply of flavanoids, but also anthocyanins, another group of powerful antioxidants. They also contain vitamin C which is also a strong antioxidant.

Another property of flavanoids is their collagen strengthening properties, which they achieve by cross-linking the fibers to form a string fibrous network. That can be used to strengthen the walls of veins, and render them less liable to stretch or expand, thus providing them with the rigidity needed to prevent varicose veins caused by the puddling of blood below weak valves. They have the same effect on arteries, providing increased strength and a reduction in the blood pressure needed to pump blood round the body.

A good intake of cherry fruit in your diet will help to improve the condition of your cartilage and other connective tissue in addition to your veins and arteries, and is particularly appropriate for athletes who place great stresses on connective tissues such as the tendons that transfer muscular energy to the levers – the long bones.

In summary, then, cherry fruit extract and the flavanoids and anthocyanins it contains, posses properties to help relieve the symptoms of gout, and various forms of arthritis, to reduce the likelihood of cholesterol oxidation that leads to heart disease and strokes, to help strengthen the walls of veins and arteries and to improve the strength of connective tissue such as cartilage and tendons.

In other words, to improve the quality of life of the majority of the population that suffers from one or more of these conditions. After learning about the health benefits of cherries and all the mounting evidence in research, my question to you is why did the FDA make cherry farmers pull the health benefits of cherries from their websites with threats of legal action if not removed? Makes a person wonder who is on our side and who isn’t?

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Date: April 26, 2008 09:36 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Una de Gato (Cat’s Claw)

Una de Gato, otherwise known as cat’s claw, is properly Unicaria tomentosa. It has been used as an herbal medicine for at least two thousand years by the people of Central and South America who gave it the name vilcacora.

It grows in jungle areas and rainforest in South America and Asia, and gets its name from the small claw-like thorns at the base of the leaves. One of the environmental benefits of the Una de Gato is that when it is harvested at three feet above the ground, it grows back to its full size of up to 100 feet within a few years when it can be harvested again to three feet. Cat’s claw has been given dietary supplement status by the FDA.

The Peruvian Asháninka tribe has used the plant as a contraceptive and for the treatment of rheumatic conditions, diabetes, acne, diarrhea, cancer, urinary tract diseases and as an anti-inflammatory, and many of the studies of cat’s claw have centered on this tribe. The studies quickly showed the active ingredients to be alkaloids, both tertracyclic oxindole alkaloids and pentacyclic alkaloids that have been found both in the bark and in the root.

The extract is obtained by boiling both the inner part of the bark and the root, each of which differs in concentration of the various alkaloids. The root is believed to better for its anti-inflammatory powers due to the quinovic acid glycoside it contains, although the relative concentrations of the various alkaloids can vary according to the time of year and to the chemotype of the plant.

Cat’s Claw comes in two chemotypes, each of which differs in the relative concentrations of the two different alkaloid types. One predominates in the pentacyclic alkaloids that strengthen the immune system, and the other chemotype in the tetracyclic alkaloids that counter that effect and reduce the speed and strength of the contractions of the heart. It is not possible to tell which chemotype a particular plant is until it has been chemically tested. They look exactly the same and it is possible for both to grow sided by side. However, the root is generally richer in alkaloids, and sells at about twice the price of the bark. Alkaloids are not the only active ingredients in Una de Gato, and it also contains tannins and phytochemicals that have an antioxidant effect and are useful free radical scavengers. They have been studied for their effects in the treatment of HIV and cancer, though mainly due to the glycoside content that will be discussed shortly. The National cancer Institute has confirmed some anti-cancer properties of quinovic glycosides derived from cat’s claw.

The four pentacyclic alkaloids have been found to have a boosting effect on the human immune system, which it does by enhancing the ability of the white blood cells and Macrophages to digest and kill off foreign organisms and debris in tissue and the bloodstream. The inference is that the herb is able to be used to treat a wide variety of infectious diseases, including many immune and autoimmune conditions including AIDS. The results with AIDs are inconclusive, although one particular study showed that cat’s claw produced accelerated healing of cold sores and genital herpes (herpes simplex virus) and shingles (caused by herpes zoster virus). Although the evidence is slight, there are indications of its possible use in treating viral conditions.

It is used in homeopathy for the treatment of a number of digestive ailments, such as Crohn’s disease, leaky bowel syndrome, colitis, gastritis and gastric ulcers among others. It is also used in the treatment of inflammatory conditions such as arthritis, rheumatism and some conditions of the prostate gland.

The tertracyclic indole alkaloids that appear to counter the immune-boosting properties of their pentacyclic cousins include rhynchophylline, hirsutine, and mitraphylline. Rhynchophylline prevents blood clots in the veins and arteries by reducing the formation of platelets, and can dilate the peripheral blood vessels of the hands and feet. It can also lower blood cholesterol levels and reduce the heart rate. Due to this effect on blood vessels, it is though to be able to improve the circulation in the brain and be a useful treatment for Alzheimer’s sufferers. Hirsutine inhibits contractions of the smooth muscle of the bladder, and so finds uses in the treatment of urinary incontinence.

The pentacyclic alkaloids pteropodine and isopteropodine are believed to have important properties beyond their phagocytosis effect on the immune system. It has been reported that they have an effect on the 5-HT(2) receptors in the brain. These neurotransmitters are used as targets for many drugs used to treat a variety of conditions such as depression, eating disorders and anxiety, and such alkaloids have a positive modulating effect on them.

The anti-inflammatory properties of cat’s claw are largely due to the very potent quinovic acid glycosides previously referred to. These have been known about only recently, and they are thought to work synergistically to reduce the tissue swelling (edema) associated with the immune system’s inflammatory reaction. Although this is believed to be largely due to the glycosides, three of the alkaloids also possess anti-inflammatory properties. This property provides the scientific background for the traditional use of Una de Gato for rheumatism and arthritis, both inflammatory conditions. Many of the digestive conditions for which the plant has traditionally used are also inflammatory in nature.

A threat to cat’s claw is the destruction of the Peruvian rainforest, although not as much as a threat as the destruction of the plant itself. Cat’s claw has reached levels of popularity so high that it is in danger of extinction due to improper harvesting. New laws being enacted by the Peruvian government should help to protect the plant, and to promote its harvesting over cocoa.

When buying cat’s claw, make sure that it is the Uncaria tomentosa form you are purchasing since there is another type, Uncaria Guianensis that contains different alkaloids and is not as potent as the real Una de Gato. Also beware of a shrub known as cat’s claw acacia, grown in Mexico and the southwest USA, since it contains cyanide derivatives and could be very dangerous if taken by mouth.

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Date: April 21, 2008 05:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Broken Cell Chlorella - Single Celled Micro alga

Chlorella is what is known as a micro alga, a single celled vegetable organism that grows in fresh water. Microalgae are microscopic species of plant life that are likely responsible for the biological evolutionary history of our planet. Most people associate algae with seaweed: marine plant life. However, this is a restricted view since algae are also common on land, although are rarely conspicuous and still require an aqueous environment if not necessarily a salt water ocean.

The reason for this is that algae have no vascular tissue to draw moisture up into the body of the plant as terrestrial plants do, and they tend to be found in tropical regions, on snow in areas of the Arctic and also on exposed areas of stone and rock in symbiosis with fungi in the form of lichens. They can also be found in freshwater ponds and rivers, and chlorella is one of these.

Its scientific name is Chlorella pyrenoidosa, and it occurs worldwide. It is said to have the highest concentration of chlorophyll of any other known plant in addition to its other highly nutritional content. The superlatives are almost limitless for such a small plant that most of the general population is unaware of. It is the first plant known to have a true nucleus, it has been around for about two and half billion years, and it can multiply itself fourfold making it the fastest growing species of plant known on earth. It beats other fast-growing algae and bamboo out of site.

So what of its nutritional content? It is believed by NASA to be the ultimate foodstuff for long-term travel in space and an ideal crop for colonizing communities. Were a space community to be established on Mars, chlorella would be the first to be cultivated under these big glass domes we all see in the movies! It is more than just a foodstuff though; it is also the most powerful known natural detoxifier for the human body, which makes it practically the ideal food. Why is this?

If any food deserves to be referred to as a ‘superfood’ it is chlorella. It consists of over 60% bioavailable protein, and contains six members of the vitamin B complex (1, 2, 3, 5, 6, 12) and also vitamins A, C, E and K. It is therefore very high in antioxidants and excellent for destroying free radicals as soon as they are formed, and before they can cause problems such as atherosclerosis and excessive cell damage.

It also contains more than its fair share of minerals such as calcium, manganese, magnesium, phosphorus and zinc, and also iodine, folic acid and a high proportion of iron. That is not all: it contains many more nutrients essential for a healthy life, but above all chlorella contains all eight essential amino acids.

Human biochemistry and metabolism need 20 amino acids to function properly, twelve of which can be manufactured by the liver from these eight: leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine, and sometimes serine is added. These are called the essential amino acids from which all the others that your body needs can be manufactured.

Amino acids are needed to build proteins and DNA, manufacture body cells, repair damaged tissue, help the immune system to protect you from invading bacteria and viruses, ensure that the oxygen you breathe gets to the cells where it is needed to sustain life and carry out many other functions besides. Without them you could not exist. Chlorella contains five times more protein and amino acids than eggs do.

The Chlorella Growth Factor or CGF is a combination of these amino acids, together with nucleic acids, carbohydrates and peptides that have not yet been completely characterized. The CGF promotes the growth of body cells, and stimulates cell repair in a way not seen before in any other food. It has been shown to promote the growth of children in a natural and safe way.

Not only this, but it has been found not to promote the growth of diseased or cancerous cells, only healthy ones. The fact that that this accelerated growth does not happen with adults indicates that the Chlorella Growth Factor supports the natural growing process, although in adults it has been seen to accelerate the repair of damaged body tissue.

Chlorella also appears to strengthen the immune system, and researchers have found the presence of a polysaccharide in the cell walls of the microalgae that acts with CGF to produce an interferon that protects the helper cells that aid Macrophages to destroy invading bacteria and viruses. It can help our resistance to influenza, choryza (common cold), fungi such as candida and many other forms of invasion by foreign agents into our bloodstream.

The detox effect of chlorella is largely contained within its cell walls that can bind with persistent toxic substances such as DDT, and bind with heavy metals to safely remove them from the body. In fact it is the ideal anti-toxin for life in today’s environment, full of vehicle exhaust fumes, pesticides and other chemical emissions. It has been claimed to be able to remove mercury from the body, but this has not been established.

Probably the only problem with the ingestion and the efficiency of the body to use Chlorella to its full extent is the strength of the cell walls. Chlorella has very strong cell walls, which could also account for the concentration of nutrients within them. the traditional method to overcome this was to mill them using small glass or ceramic beads to break the cell walls down, but the Japanese have come up with a more effective means. High frequency sound waves are used to break the cell walls down supersonically, a technique known as ‘cracking’, and once cracked the cells can release up to 65% of its nutrients, compared to the 50% of the milling method.

The nutritional content of single celled microalgae such as chlorella is amazing, and if the was only one food that you were able to eat, then this would be it. There is no other known species of plant or animal life that provides the range of vitamins, minerals, proteins and amino acids that chlorella does, and it truly is the king of all superfoods.

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Date: March 21, 2008 12:19 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Boost digestion with Bifidus Longum and Acidophilus Probiotics

Prior to discussing how you can boost digestion with bifidus longum probiotics, let's first have a look at probiotics in general and why they are so beneficial to us.

Probiotics are also known as microflora, and are beneficial organisms that live in your digestive tract. Not all microorganisms are bad news, and many are essential for good health. Included in these organisms are various types of bacteria and yeasts, each of which has a specific part to play in the proper functioning of your body. Because of this they are found in foods all over the world, including yoghurt and fermented vegetables such as German sauerkraut and Korean kimchi.

Among their major benefits to health are that they help to support your immune system, they aid the digestion and absorption of food, they provide increased energy by improving the metabolic conversion of blood glucose to energy, and they can also help to delay aging. However, you should be aware that not all probiotics are the same, and when used properly some can have the same effect as antibiotics.

They are used to cure many digestive problems such as irritable bowel syndrome and diarrhea, and can also help to relieve heartburn and acid reflux. In fact your lower intestine should contain a minimum of 85% friendly bacteria, and 15% at most of unfriendly bacteria that can cause disease if they over-colonize your colon. It might surprise you to learn that you have around twenty times more bacteria in your body than body cells.

One of the best known of the probiotics are members of the lactobacillus family that are contained in yoghurt and curds and whey, so Little Miss Muffet had the right idea. However, you might not have the right idea in eating commercial yoghurt because, while raw yoghurt does contain these helpful bacteria, the type that you buy in pots in the supermarkets has likely been pasteurized - a process that kills off the bacteria. Unless the product has been seeded with live bacteria after pasteurization, then there will likely be none in your yoghurt! Make your own!

So what are the probiotics that do you most good, and in what form should you consume them? The common friendly bacteria are the already mentioned lactobaccilus, and then lactococcus, streptococcus thermophilus, enterococcus, bifidobacterium and others. Bacteria are easily killed off by the acidic conditions in your stomach, and since they must be taken live they should be consumed in a form that can resist the stomach acid.

There are many ways in which they benefit you, the main ones that are currently understood being:

Lactic acid production: the presence of lactic acid in the gut prevents stops or slows the growth of harmful bacteria by increasing the acidity. Some probiotics, known as lactic acid bacteria (LAB) can do this. Most bacteria do not like acidic conditions.

Supporting the immune system: LAB bacteria have been shown to increase the production of cytokines that stimulate the activity of the Macrophages that attack foreign viruses and pathogenic bacteria. The LAB also promotes the formation of NK-cells (natural killer cells) that destroy cells that have been infected by viruses.

Adhesion site blockage: bacteria attach themselves to your intestinal walls at specific adhesion sites. Friendly bacteria can colonize these sites and so prevent the pathogens from adhering.

Effect on the Intestinal wall: the intestinal wall has a natural mucous barrier that helps to prevent the passage of allergens and pathogens into the bloodstream through the intestine. Probiotics can strengthen this barrier, and also alter the nature of the mucous to render it less liable to penetration by these unwelcome visitors.

So where does bifidobacteria come into this? There is a number of strains of this bacterium living in the human body, but Bifidus longum is the most common or most abundant of these. Although it is the most common bacterium found in commercially available probiotic products, high numbers have to be consumed for the proper health benefits. However, commercial yoghurts contain very little of this bacterium, or even none at all. This is largely due to the pasteurization previously discussed, that kills the bacteria at high temperatures. Unfortunately this process is not selective, and in ridding the products of bacteria that could make you seriously ill, the beneficial bacteria are also destroyed.

This is a shame because Bifidus longum has been shown to inhibit E.Coli that can cause serious conditions of the digestive system. Among these are severe diarrhea and an inflammatory condition in the colon as the immune system tries to expel these nasty bacteria. This bacterium is particularly dangerous to the weak, such as the aged, children and people already weakened by illness.

It also helps to counteract yeast and other vaginal infections and when taken with other probiotics is believed to help in colon cancer cases. Among its other benefits are its part in the biosynthesis of thiamine, riboflavin and other vitamin B forms in your intestine, and also the absorption and assimilation of these vitamins by your body. It is also believed that it might help to reduce the cholesterol level in your body through its uptake of bile salts from the colon.

The major destructive elements of Bifidus longus are antibiotics of any kind, whether they be penicillin variants or tetracycline, and although the latter is used mainly for infections of the respiratory tract, it is ingested by the gut and effectively reduces the population of the bacteria that are needed for optimum health. That is one of the reasons why antibiotic use should be restricted to only what is necessary, and not use indiscriminately for all infections. Unless administered intravenously or site targeted, antibiotics kill off the good with the bad!

The other activities of Bifidus longus, such as removing the by-products of our metabolism that could be toxic if left to roam our bodies, render this bacterium as useful to your body as any vitamin or mineral supplement you could take. It is a supplement that many either overlook or are not even aware of, yet one that can make a significant difference, not only to your digestive and intestinal health, but also to you general overall wellbeing.

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Date: February 15, 2008 02:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Alpha Lipoic Acid is a Powerful Antioxidant

The discovery of alpha lipoic acid at the University Of Texas Chemistry Department in 1951 was not heralded with trumpets of joy at the revelation of such a powerful antioxidant, but was instead largely ignored. This is largely due to the biochemistry involved not being fully understood at that time, but by the 1980s it was a commonly used supplement, recommended for several medical conditions.

Chemically, the substance is a 5-membered cyclic disulphide with a carboxylic acid grouping. Biochemically, it’s extremely powerful antioxidant properties are largely due to the fact that it one of those rare active molecules that are soluble in both water and fats, and in fact is the only such antioxidant currently know. One of the properties that this ability enables it to possess is to cross the blood-brain barrier, and apply antioxidant propertied to the brain.

Antioxidants are essential to human life in that they destroy free radicals. These are compounds with free unpaired electrons that destroy human body cells in their hunt for electrons to pair with. Electrons come in pairs in organic animal tissue, just as they do in organic compounds. However, under certain circumstances this pairing can become destroyed, leaving a molecule with one of its electrons without a partner.

The factors that lead to this situation are many and varied, and our own biochemistry can produce free radicals during the normal chemical processes of life. However, pollution can also lead to the oxidation processes that create free radicals, common such pollutants being cigarette smoke, vehicle exhaust fumes, pesticides and the like. Excessive exposure to the UV content of sunlight can also create free radicals as can eating barbecued and smoked foods, and exposure to carbon monoxide and peroxides. Even the biochemical conversion of glucose to energy in our bodies creates free radicals.

These free radicals can destroy body cells, including DNA, and can create conditions such as premature aging due to destruction of skin cells, destruction of brain cells, strokes, cancers, diabetes, atherosclerosis due to oxidation of LDL cholesterol that deposits in the main arteries of the body, stiffening of the joints and many other undesirable conditions.

Free radicals are destroyed rapidly by antioxidants: the reaction is very rapid and most are destroyed immediately they are formed before they can do harm. Fortunately, if your diet is well maintained, the body possesses many antioxidants such as vitamins A, C and E, and other substances such as Coenzyme Q10, flavanoids, xanthenes, polyphenols and carotenoids. Many of these are found in highly colored foods, and if your food is brightly colored, it should contain a good supply of antioxidants.

However, the problem with all of these is that they are either fat and oil soluble or water soluble, which means that they can either be freely carried round the body by the blood or have to be emulsified by the bile and transported via the lymphatic system that places restrictions on their effectiveness in certain organs of the body. The fact that alpha lipoic acid is soluble in both water and fats enables it to be carried to all parts of the body and to every organ, and can cross water/fat barriers that other antioxidants cannot do.

It can therefore be carried via the blood to the brain and carry out an essential antioxidant function within our brains. It took a long time for this property of ALA to be recognized and its consequent health benefits understood. It is, in fact, the ideal antioxidant. The substance provides many known benefits to the body due to its antioxidant properties and also helps the body to generate the maximum possible amount of energy from the blood glucose and thus improve the energy balance of your body.

However, it is with its antioxidant properties that we are most concerned here. One of the benefits of these properties is its effect in holding back the visible effects of aging on your body. Because it is both water and fat soluble, alpha lipoic acid can help destroy free radicals in every part of your skin; the areas served by the blood and the fatty and oily secretions are protected simultaneously by the same strong antioxidant. The end result is a reduction in the destruction of the cells through the dermis and epidermis and a reduction in the degree of wrinkling with age.

Its antioxidant effect in the brain renders ALA in great demand for reducing cognitive impairment with age. In fact studies have indicated that alpha lipoic acid can improve memory and brain function in the aging and the elderly. This effect appears to be increased by the synergistic combination of alpha lipoic acid and acetyl-L-carnitine that work together to prevent cognitive decline in the brain through the effect of free radicals.

There is evidence that during a stroke, ALA works synergistically with vitamin E to reduce the effect of free radical damage on the vulnerable brain cells, and so reduce the longer term effects of the stroke. Together with ALC, it also reduces oxidative stress on the mitochondria of cells and in so doing helps once again to reduce the effects of aging, and maintain the body’s capacity to generate energy from blood glucose.

Cardiovascular disease is the main killer of the western world, largely due to our diets, and this is especially true of the USA. Although Americans appear unable to change their unhealthy diet, alpha lipoic acid and acetyl-L-carnitine can be used to offset much of the damage done. ALA reduces the development of atherosclerosis through its antioxidant properties and the reduction of the adhesion of monocytes to the artery walls.

LDL trapped in the wall of the artery can be oxidized and enable monocytes to also enter under the surface of the arterial wall, where it changes into Macrophages and ingests the oxidised LDL, causing the plaque that forms atherosclerosis. As the plaque thickens, the artery becomes increasingly restricted until the blood flow is significantly reduced or even stopped, causing cardiac failure or a stroke.

Alpha lipoic acid can prevent this free radical oxidation from occurring by destroying them before they act on the low density lipoprotein (LDL). Acetyl-L-carnitine works with the ALA to achieve this, as does another substance known as carnosine. Between them, these three musketeers work to keep your arteries clear and your brain functioning as it should, though it is the ALA that is most powerful due to its oil and water solubility properties.

Although alpha lipoic acid is available as a supplement, either alone or in combination with acetyl-l-carnitine, it is also available from natural food sources. It is particularly rich in offal such as heart and kidney, and also in broccoli, spinach and brewer’s yeast. It is also available in beef, and it is here that burgers can perhaps repay some of the damage that it causes. However, it is not a recommended source since burgers still cause more damage to your health than any of their constituent nutrients can allay.

Like any other supplement, you should seek medical advice before taking any substance if you have a health condition. Nevertheless, the benefits of alpha lipoic acid are such that it is difficult to see it doing anything but good. However, please consult your physician if are taking other drugs.

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Date: November 10, 2007 02:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Maca a Magic Root?

Maca is packed with nutrients; loaded with vitamins and minerals to help fuel brain function and ease hormone irregularities as well as nourish the body.

Maca contains:
1. vitamins: B1, B2, and vitamin C
2. Alkaloids: contains 4 novel alkaloids: Macaina 1, 2, 3, 4.
3. Bismuth: Aids in combating bacteria that causes gastritis.
4. Calcium: supports strong bones and teeth.
5. Copper: supporting hemoglobin production
6. Fatty acids: contains 20 fatty acids 7. Silicon: helps hair, skin, nails, and connective tissue.
8. Iron: supports hemoglobin also.
9. Magnesium: essential for protein synthesis, and activities of muscles and nerves.
10. Manganese: essential mineral
11. Phosphorus: regulates the transmission of neuromuscular chemicals and electrical stimuli. Important for the hemostasis of calcium, and the reactions of lipids, carbohydrates, and proteins. The body’s chemical energy is stored in phosphate compounds.
12. Potassium: participates in the regulation of osmotic pressure; its activity is carried out inside the cells.
13. sodium: when working with potassium helps reduce arterial pressure and hypertension.
14. Tannins: useful in the treatment of diarrhea. Combined with other medicines, they have the utility of treating inflammatory processes like ulcers and sores.
15. Zinc: a cofactor of dehydrogenises and carbonic anhydrite; its lack can cause skin rashes, taste disturbances, and mental lethargy.
16. Carbohydrates: quality carbs.
17. Fructose: Natural fruit sweetener
18. Micronutrients: minerals which help with the production of antibodies.
19. Proteins: rich in bio-available maca protein average of 11% grams in dry root.
20. Starch: chemical compounds that influence the nutrition and health of consumers.
21. Fiber: loaded with cellulose and lignin which stimulates intestinal operations.
22. Macronutrients: essential vitamins and minerals, nutritive properties to help convalescent people who are diagnosed with anemia.

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Date: May 31, 2007 02:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Papaya- May Be A Fountain of Youth

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Buy Papaya at Vitanet LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1555)

Date: May 18, 2007 01:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium

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Protect the Heart with D-Ribose, Coenzyme Q10, L-Carnitine, and Magnesium at Vitanet ®, LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1539)

Date: May 11, 2007 10:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Breast Cancer and Natural Supplements

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Fight Cancer with Natural Herbal Supplements like calcium d-glucarate at Vitanet ®, LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1537)

Date: March 02, 2007 11:34 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Power Plant of the Amazon

Enzymatic Therapy Amazon Herbs

It may surprise most Americans to know that rainforest plants are the original source for one-fourth of the chemotherapy medications used today. Plants offer a plethora of beneficial compounds, and rainforests contain a superabundance of beneficial plants.

In fact, plant medicines are the most widely used medicines of all types in the world. Over eighty-five percent of the world’s population uses plant and herbal medicines as their primary medicines. That’s 5.1 billion (5,100,000,000) people worldwide! While Americans overwhelmingly use synthetically manufactured pharmaceuticals to cure their ills, the vast majority of Earth’s inhabitants use healing plant medicines instead.

One of the most powerful healing rainforest plant medicines is cat’s claw, or Uncaria tomentosa. This high climbing woody vine grows at the base of tall trees in the Peruvian rainforest. The plant’s claw-shaped thorns latch onto the trees and spiral further upward, nourished by the lush rainforest environment. For over 2,000 years, the Ashaninka, a tribal people of the Peruvian rainforest, have used the root of U. tomentosa to treat illnesses in the tribe, including asthma, bladder infections, infected wounds, arthritis, bone pain, bowel inflammation, and cancer.

Q. I’ve heard about cat’s claw, but what does it do and how do I know which one is right for me?

Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today. One reason that it’s so confusing is there are so many kinds of cat’s claw supplements-there are cat’s claw leaves, cat’s claw bark, and even cat’s claw twigs. While each of these supplements claim to help the immune system, it is the root of Uncaria tomentosa that is proven to impart the true cat’s claw health benefits.

Scientists, who have extensively studied every part of the plant, discovered that extracts made from selected cat’s claw roots possess the healing power to treat and prevent diseases like cancer, rheumatoid arthritis, ulcers and degenerative diseases. In addition, it demonstrates anti-inflammatory, anti-viral and anti-microbial benefits.

Adding to the confusion is the fact that not all Uncaria tomentosa roots actually contain healing properties.

Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. The Ashaninka healers, or sancoshi, are able to actually “see” the good spirits hidden inside the root of the plant before they harvest them.

Some cat’s claw plant roots have the good spirits. Some don’t. If the good spirits are mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no apparent differences in the plants or the roots to the untrained eye, only certain cat’s claw roots possess the power to heal. And, for a very long time, only the Ashaninka tribal healer seemed to be able to identify them. They call the good spirit cat’s claw Saventaro, or “powerful plant”.

However, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they could “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to be important medicinal compounds called pentacyclic oxindole alkaloids (POAs). Research has learned that POAs provide powerful benefits for the human immune response.

Q. Why are good spirits, or POA’s, good for the immune system?

Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.

Certain POAs help white blood cells called Macrophages work faster. The Macrophages’ job is to engulf and digest foreign material. This means that Macrophages can ingest m ore bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin that is secreted by Macrophages. This Macrophage-secreted interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals that are essential to an activated immune system.

POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies. And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T cells, Suppressor T cells, and Killer T cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.

Q. Can cat’s claw and other plants in the rainforest really cure diseases? Isn’t that just folklore?

It’s folk use and modern science combined-plants have long been known for their ability to kill cancer cells. In fact, the National Cancer Institute (NCI) has identified over 3000 plant extracts that can kill cancer cells. More than 70 percent of these plants are found only in the rainforest.

Q. What is it about the rainforest that gives plants like cat’s claw these cancer killing compounds?

Most of the time when we talk about rainforests, we’re talking about the tropical rainforests. While other forests, like the old-growth temperate forests of the Pacific Northwest, also have high rainfalls and tall trees, the tropical rainforests located near the equator are where most plant medicines come from.

The Amazon rainforest in South America is the world’s largest, covering an area about two-thirds the size of the continental United States. Depending on the elevation and distance to the equator the Amazon rainforest receives between 160 and 400 inches of rain per year. The rain is spread pretty evenly from January to December-it’s always the rainy season-and the temperatures remain between 75-80 degrees Fahrenheit all year.

This fertile environment continually recycles itself. When leaves fall from the trees, flowers wilt, and animals die in the rainforest-all of the nutrients are recycled back into the roots of the trees and plants. Because the rainforest reuses almost everything that falls to the ground, the plant growth is amazingly rich in alkaloids and other medicinal compounds. Researchers think these compounds and alkaloids, like POAs, protect the plants from illness and insect attacks. These are the very same compounds that protect us from disease.

Q. When the Ashaninka harvest the cat’s claw roots, does it impact the rest of the plant?

No. The Ashaninka work intelligently to keep rainforest cat’s claw plants perpetually healthy. The Ashaninka employ responsible and innovative harvesting techniques to keep the plants alive and tribal members healthy. Individual cat’s claw plants are never completely harvested. Only one third of the lateral roots are collected at any one time to allow re-growth by the remaining root. Once a plant’s lateral roots have been partially harvested, that plant is left to regenerate, and no more root is harvested from it for 10 years.

Q. Why are the Ashaninka willing to share their cat’s claw?

They are generous people. The Ashaninka see no benefit in hoarding cat’s claw for themselves alone. They also want to make sure that the plant’s healing properties continue on. As their homelands continue to be destroyed by deforestation, rainforest peoples are also disappearing. There were an estimated ten million tribal and indigenous peoples living in the Amazonian Rainforest in 1510. Today there are less than 200,000.

Since the 1900’s more than 90 indigenous tribes have died out and disappeared. Each time a rainforest medicine man or woman dies without passing their arts on to the next generation, the tribe and the world loses thousands of years of irreplaceable knowledge about medicinal plants. With them, centuries of accumulated knowledge of the medicinal value of rainforest species have been lost.

A good example of the impact of this loss can be seen in cat’s claw. When European explorers began venturing into the Amazon River basin, t hey were skeptical of the stories the Ashaninka people told them of U. tomentosa’s amazing healing powers. But when the explorers became sick with colds, flu, or other illnesses, they harvested cat’s claw root for themselves and gave the plant a try. Sometimes the explorers got better when they used the cat’s claw root, sometimes they stayed the same.

Q. Why didn’t the cat’s claw root help all the explorers?

Because some cat’s claw plant roots have good spirits-POAs-and some cat’s claw plant roots have tetracyclic oxindole alkaloids, or TOAs. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all. All U. tomentosa plants look virtually identical, so it’s hard to tell if they have the healing POAs or non-helpful TOAs.

What makes cat’s claw identification even more challenging is the fact that plants with POAs one year will have TOAs the next. Cat’s claw plants seem to change their alkaloid chemotypes at will, an incredibly powerful accomplishment for a plant to possess. Harvesting of cat’s claw roots that contain POAs is very tricky. Unless the person gathering the root extract is an Ashaninka sancoshi. These medicine men know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root. When scientists studying cat’s claw discovered they could “see” presence of TOAs using HPLC technology, they were able to harvest cat’s claw root extracts with POAs that consistently helps people get and stay healthy.

Q. Do some cat’s claw root extract supplements contain TOAs?

Yes they do. And buying those products will only benefit the cat’s claw distributor; they won’t help you stay healthy. When cat’s claw root is harvested from the rainforest, responsible supplement maker examine the root with HPLC to make sure that only POA roots are collected. But, this identification of the chemotypes takes significant time and costs money. For these reasons, many cat’s claw distributors don’t include this important process in their harvesting. The POAs and TOAs are simply just mixed together and sold as a cat’s claw product with no mention of any alkaloid content on the label.

Q. Why should I avoid TOAs?

While the POAs in cat’s claw root extracts have numerous benefits to the immune system, the TOAs have different effects in the body, none helping the immune system cells. Most importantly, however, when POAs and TOAs are mixed together, the TOAs actually work against the POAs. TOAs reduce the capacity of POAs to beneficially modulate the immune system.

Q. How can I be sure the cat’s claw I buy is POA cat’s claw?

Read the label of the cat’s claw root extract product you are considering buying. If it does not clearly state that it is the high POA cat’s claw, then chances are that it’s not.

Q. What do the Ashaninka receive in return for the cat’s claw harvesting?

The Ashaninka and reputable distributors of cat’s claw root extract have established a mutual and ethical relationship. Both groups benefit from the sale of the plant material. Maintaining this relationship is important for both the tribe and the distributors.

The distributors are paying a fair price for the raw material directly to the tribe. No intermediary is involved. This payment covers the raw material itself, a license-fee for the k knowledge of the plant, and a guarantee (from both sides) of a lasting relationship. Payment is also made for the protection of the rainforest. No deforestation is allowed. The area where the cat’s claw materials are processed is also leased and payment is made for this, as well.

This arrangement allows the Ashaninka to make independent decisions in how to spend this income from sale of their cat’s claw plants. They have been able to make improvements in the tribe’s water supply and in their living areas. They are also able to obtain outside medical aid as needed and provide for education of their children.

The partnership with cat’s claw distributors has created a sustainable resource for the Ashaninka. The tribe has been able to not only preserve their rainforest, but also compete financially with unsustainable income sources offered by timber and agricultural firms.

Q. Why is it important to preserve the rainforest?

The most amazing fact about these impressive medicinal plants is the vast number that5 has yet to be discovered. In fact, the rainforest’s abundance is one reason it is home to so many healing plants. Within a four square mile patch of rainforest, you could see 1500 species of flowering plants, 750 species of trees, 125 mammal species, 400 species of birds, 100 reptile species, 60 amphibian species, and 150 different species of butterflies.

Unfortunately, not everyone looks to the rainforest for the same reasons. Many consider its real value in board feet and cultivated acreage. The forces pushing industrial development move quickly; experts estimate that we’re losing over 130 plant, animal, and insect species every day/ That amount to almost 50,000 species a year.

A combination of logging, petroleum interests, cattle grazing operations, and, of course, our own consumer appetites are putting pressure on rainforest resources. The consequences are sobering:

• Rainforests once covered 14% of the earth’s land surface; it’s only 6% today
• The last remaining rainforests could be consumed in less than 40 years.
• Nearly half of the world’s species of plants, animals and microorganisms will be destroyed or severely threatened over the next quarter century due to rainforest deforestation.

By leaving the rainforest intact, however, and harvesting its many nuts, fruits, oil-producing, and medicinal plants, the rainforest has more economic value than if it was cut down for timber or to make grazing land for cattle. If managed properly, the rainforest can provide the world’s need for sustainably harvested natural resources on a perpetual basis. That’s what the Ashaninka are doing with their cat’s claw harvesting.

Conclusion

The discovery of medicinal plants is dependent upon healthy rainforests. When an acre of tropical rainforest is lost due to deforestation, the impact on the number of plant and animal species lost and their possible uses is staggering.

We can all help the development of sustainable rainforest industries. By purchasing renewable and sustainable rainforest products, like POA type cat’s claw root extract, we are keeping rainforests alive and well. By benefiting from the innate wisdom of the Ashaninka people we are keeping ourselves just as alive and well. By honoring the science and the sacred of the world’s rainforests, like my friend the oncology nurse, the massive wealth and diversity will be there for generations to come.

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Date: January 26, 2007 06:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mushrooms are good for the Immune System

Medicinal Mushrooms Grown on Purple Kculli Corn Yield Life Changing Results

Even though we treat them like vegetables, mushrooms aren’t really plants. They’re fungi and fungi grow much differently than fruits and vegetables. Most food plants, like strawberries, broccoli, and red bell peppers make chlorophyll from sunlight to gain the nutrients they need to grow. Mushrooms don’t make chlorophyll; to get the nutrients they need to grow, mushrooms release enzymes into the forest floor or flora they’re living on to break down the organic matter into a form the mushroom can absorb.

Because most mushrooms that we eat or use today are raised as crops, or cultivated, they are grown on a variety of substrates. Similar to the commercial potting soils you can buy at nurseries and garden stores, mushroom substrates vary widely in quality and the kinds of nutrients within. Mushrooms are really unique in that they can grow on almost anything, such as sawdust, shredded newspaper, and straw.

However, mushrooms are only as nutritious as the substrate they were grown on-even those unique varieties called medicinal mushrooms. While the simple button mushrooms found on pizza are most often eaten for their woodsy taste and texture, the use of medicinal mushrooms is much more complex. These mushrooms are valued because they contain numerous compounds that have been extensively studies by researchers for their ability to activate cells of the immune system.

Researchers have recently discovered that when medicinal mushrooms are grown on a Purple Kculli (pronounced ka-coo-lee) Corn substrate, the resulting mushrooms are jam-packed with powerful and potent disease-fighting compounds. Beautiful Purple Kculli Corn has long been used by the people of the Peruvian Andes as a tasty vegetable, natural food color, and powerful functional food-keeping them healthy and free of disease.

In this issue of Ask the Medicine Hunter, we’re going to talk about four powerful medicinal mushrooms that, when grown on Purple Kculli Corn, have even more potent compounds to prevent and treat cancer and other serious health problems.

Q. How exactly do medicinal mushrooms prevent and treat cancer?

A. Medicinal mushrooms are very complex. They contain numerous compounds that have been extensively studied for their ability to activate cells of the immune system. Some of the most amazing immune boosting compounds in medicinal mushrooms are beta-glucans 1-3, beta glucans 1-6, arabinogalactins, and arabinoxylans – compounds that work “hand-in-hand” with certain cells of the immune system. But to get abundant amounts of these compounds, medicinal mushrooms must be grown on substrates with high levels of nutrients. And the most nutrient dense substrate of all comes from Purple Kculli Corn.

Q. Why is Purple Kculli Corn extract good for growing medicinal mushrooms?

A. You’ve probably heard that brightly colored fruits and vegetables (like beets, broccoli, and blueberries), have more antioxidant power than paler fruits and vegetables (like iceberg lettuce, onions, and garlic). In fact, the deeper the color, the better. And there is no deeper color in nature than the deep purple of Purple Kculli Corn grown in the lush coastal plains of Peru. The kernels from Purple Kculli Corn are not only naturally beautiful, the pigment itself is extremely healthy and have been used by the people of the Peruvian Andes for centuries as both food and food coloring.

Once harvested, the Purple Kculli Corn is naturally processed into an antioxidant-rich extract. When certain medicinal mushrooms are grown on Purple Kculli Corn extract, the Purple Kculli Corn becomes a super-substrate, producing medicinal mushrooms with incredible amounts of the immune-boosting compounds. And when Purple Kculli Corn extract is added to medicinal mushroom formulas the antioxidant power increases, too.

Q. How do the medicinal mushroom compounds fight disease?

A. When bacteria, viruses, or other pathogens are present in the body, white blood cells, or leukocytes, swing into action. Leukocytes work together to defend the body against infections, like colds or the flu, as well as diseases that start within us, like cancer. These disease fighting cells are the backbone of the body’s defense system. And each type of cell works in different ways.

The Macrophage, a name that means “big eater,” is a first-strike leukocyte that protects us from disease by, quit literally, devouring invading pathogens. Natural Killer (NK) cells act like sentries – constantly prowling for cancer cells, killing them quickly when they’re discovered. B-cells are the immune system’s military intelligence, seeking out targets and communicating their coordinates, while T-cells are the foot soldiers, destroying the invaders that the intelligence system has identified.

Scientists have long known that medicinal mushrooms help make white blood cells more deadly. But until recently, they weren’t sure how. Research has now shown that Macrophages and NK cells have receptor sites specifically for beta-glucans 1-3 and beta-glucans 1-6. When the beta-glucans bind to the Macrophages and NK cells, they make the lymphocytes stronger and more lethal. By increasing the lymphocytes’ strength, beta-glucans help them churn out more of the specialized chemical messengers, too.

Arabinogalactins and arabinoxylans, powerful polysaccharides found in medicinal mushrooms, are potent stimulators of the immune system. These compounds increase the activity of interleukins, interferons, and a tumor necrosis factor, all key components in a healthy immune system. When medicinal mushroom extracts with high amounts of Arabinogalactins and arabinoxylans are taken, diseases are dramatically reduced.

Researchers found that complex polysaccharides in four varieties of medicinal mushrooms – Agaricus blazei (Agaricus), Grifola frondosa (Maitake), Coriolus versicolor (Coriolus or Turkey Tail), and Ganoderma lucidum (Reishi) – are serious cancer fighters. The chart below explains how:

Mushroom Health Benefit

Agaricus (Agaricus Blazei)

Agaricus not only contains the greatest number of medicinal compounds, it also contains a powerful anti-tumor polysaccharide that all other medicinal mushrooms are lacking. Recently, 100 women who were receiving carboplatin, a chemotherapy drug used to treat ovarian cancer, volunteered for an important study. Half of the women were given an extract of Agaricus mushrooms, while the other half were given a placebo or dummy pill. The researchers discovered that NK cell activity was significantly higher in the Agaricus group. The women in this group were also less nauseated, fatigued, and wear than the women taking the placebo, an important consideration for people with cancer.

Maitake (Grifola Frondosa)

Maitake is one of the most researched of all medicinal mushrooms. In one clinical study, the effect of Maitake mushroom compounds were studied in ten patients with cancer who were not currently taking any chemotherapeutic drugs. The researchers found that the Maitake not only significantly stimulated NK cell activity, it also repressed the cancer’s growth, and stopped the tumors’ ability to metastasize, or spread to other parts of the body. And in another clinical study, 165 patients with various types of advanced cancer were given Maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, 69% of breast cancer patients, and 62% of lung cancer patients. Plus, when Maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.

Coriolus(Coriolus Versicolor)

Versicolor compounds show great promise as cancer immunotherapy agents in all cancer stages. In one clinical trial, 34 patients with advanced terminal lung cancer were given Coriolus versicolor polysaccharides or a placebo (dummy pill) for 28 days. While the group getting the Versicolor felt less fatigued and sick, very important considerations at the end-of-life, there were no changes in the placebo group.

Reishi (Ganoderma Lucidum)

Reishi mushrooms are too tough to eat, but they’ve been used medicinally for centuries and have been extensively researched. In a safety study to determine Reishi’s effect on blood thinning mechanisms, healthy volunteers received 1.5 gm Reishi or placebo daily for 4 weeks. There were no significant changes in either group and all blood clotting measurements remained within the normal range, demonstrating its safety. In a recent clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.

Not only do Agaricus, Maitake, Coriolus, and Reishi have incredible amounts of immune boosting polysaccharides, when they are grown on Purple Kculli Corn, they also have a much higher ORAC value than mushrooms grown on other substrates.

Q. What are ORAC values?

A. ORAC, or Oxygen Radical Absorbance Capacity, is a measurement of the antioxidant power in fruits and vegetables. The higher the power, or ORAC value, the stronger the antioxidant is against free radicals. While free radicals are made by breathing oxygen and digesting food, and are simply the consequences of being alive, the older we get the more free radicals we make. And the more free radicals we make the more destructive they can be. Free radicals will rip membranes, wreck cells, cripple mitochondria, and ruin DNA. As this damage accumulates, even more free radicals are made. And if not stopped or slowed, this might lead to heart disease, arthritis, diabetes, dementia, and cancer.

Q. How does Purple Kculli Corn increase the ORAC value of medicinal mushrooms?

A. All brightly colored fruits and vegetables have very high ORAC values; and the higher the ORAC value – the greater the antioxidant power. Not only can we measure the ORAC values of fruits and vegetables, we can also measure the ORAC values of mushroom substrate extracts. Purple Kculli Corn extract has an ORAC value of 1789 (measured in umolesTE/gram). Now, remember that mushrooms are fungi, not fruits and vegetables, and they gain most of their nutrients from the ground (or substrate) they are grown on. When mushrooms are cultivated or “farmed” on substrates with a high ORAC value, they will absorb compounds from the substrate giving them a higher ORAC value, too. So growing mushrooms on antioxidant rich, high ORAC value, Purple Kculli Corn yields medicinal mushrooms with high ORAC values as well.

Q. Some mushroom supplements have more than four medicinal mushrooms. Wouldn’t a mushroom supplement with seven mushrooms or more have a higher ORAC value than a supplement with only four?

A. Well, more is not always better – especially when it comes to medicinal mushrooms. Some supplements have a “kitchen sink” selection of mushrooms. The makers of these supplements hope that by adding modest amounts of many mushrooms, they will end up with a product that just might have some health benefits.

Clearly, it’s not how many or how exotic the mushrooms are in a medicinal mushroom supplement, it’s the substrate that mushrooms are grown on that makes the difference.

Q. How can I make sure the medicinal mushroom supplement I buy contains natural and organic mushrooms grown on Purple Kculli Corn substrate?

A. Become a label reader! Medicinal mushroom formulas have a statement showing accreditation from a certifying agency, such as the American Food Safety Institute, International; California Organic Farmer Association, Minnesota; or Crop Improvement Association, on the label, and have met certain criteria. They must be grown without chemicals or pesticides. The growers must be certified as organic mushroom produces by an accredited third party. And the growers must keep a record of their production and handling practices.

Conclusion

Of the nearly 38,000 varieties of mushrooms, Agaricus blazei, Grifola frondosa, Coriolus versicolor, and Ganoderma lucidum have impressive medicinal properties. With a little help from Purple Kculli Corn, these mushrooms can provide even more potent and powerful cancer preventing properties for superior mushroom supplements.

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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1446)

Date: November 22, 2006 01:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Q. How did research discover maitake’s health benefits?

A. Because maitakes are well known as healthy food, researchers interested in medicinal mushrooms have studied them extensively. They discovered many maitake compounds with dramatic health-promoting potential. One of these compounds, maitake D-fraction, has particularly powerful anti-cancer effects.

In lab studies, D-fraction stops the growth of cancer cells and cancerous tumors. Maitake D-fraction stimulates the activity of two white blood cells, Macrophages and natural killer cells. These white blood cells then trigger the production of interleukins and other lymphokines, two biochemicals that help mediate the immune response. Maitake also inhibits some of the mechanisms that promote metastasis, or spread, of cancer cells in the lymph system and bloodstream.

Because of this success, maitake D-fraction is now being used in preliminary clinical trials of women with breast cancer. One study has reported significant improvement of symptoms, including reduction of the tumor. The maitake D-fraction was given to breast cancer patients in addition to standard chemotherapy.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1426)

Date: November 22, 2006 01:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Q. What effect do the POAs from cat’s claw root have on our immune system?

A. Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as cold and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.

Certain POAs help white blood cells called Macrophages work faster. The Macrophages’ job is to engulf and digest foreign material. This means that Macrophages can ingest more bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin, that is secreted by Macrophages. Interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals essential to an activated immune system. (90% of white blood cells are in reserve)

POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies.

And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T-cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T-cells, Suppressor T-cells, and Killer T-cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.

European health care providers are often very comfortable integrating the use of herbal and nutritional supplements as vital components of their patients’ cancer treatments. In Austria alone, cat’s claw extract is used together with conventional treatment (chemotherapy, radiation, and/or surgery), to treat hundreds of cancer patients every year!

A recent clinical observational study looked at POA cat’s claw extract in 78 people with very advanced brain cancer. All of the participants reported that the special POA cat’s claw helped them feel better, have more vitality, and reduced side effects (such as nausea) caused by their conventional cancer treatment. The researchers felt that POA cat’s claw extract may also prove to have benefit in extending the life span of people with these types of deadly brain cancers.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1424)

Date: October 26, 2006 12:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lifespan Of Some Cells In The Human Body... 8 Essential monosaccharides

the 8 Essential sugars (monosaccharides) needed for optimal health!

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Date: October 15, 2006 04:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Scientific Research Backing Glyconutrition

There are over 20,000 studies conducted annually on glycoforms alone. Researchers from universities and major pharmaceutical companies realize the importance of this new discovery. Breaking the “sugar-code” will mean a tremendous advancement in health and medicine.

Studies confirm that the eight essential biologically active sugars can accomplish amazing results. The following are just a few examples of the exciting possibilities of Glyconutrition:

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Date: August 09, 2006 01:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ImmPower AHCC - Japan’s best selling immune enhancing supplement now available in the USA.

In 1984, Japanese scientists discovered that by hybridizing several mushrooms used in traditional healing they could develop a natural compound that would give the body what it needs to maintain “super immunity.” Named active hexose correlated compound (AHCC), it has a unique alpha-1,4 glucan structure and low molecular weight that research shows provides unsurpassed support for the immune system’s front line defenses.

• Maintaining peak Natural Killer cell function.
• Supporting enhanced cytokine production
• Promoting optimal T-cell and Macrophage activity.

Based on over 20 published studies and the clinical experience of hundreds of hospitals and tens of thousands of consumers, AHCC has become Japan’s best selling immune enhancing supplement. Now its available in America as Immpower AHCC, where its gaining the endorsement of leading experts in nutritional medicine.

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Date: February 16, 2006 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Frontiers in Enzyme Supplementation

New Frontiers in Enzyme Supplementation

By Nick Rana, CN, NOW Quality Assurance

Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.

Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.

The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.

Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.

Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.

The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.

TECHNICAL NOTES:

Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-Macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).

While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).

The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.

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Date: February 04, 2006 09:54 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Echinacea: why does it work in real life but not in trials?

The Wellness Revolution

Why clinical trials must take into account real dosage amounts!

You took it, and it worked. You’re one of legions of people all over the world who have found the little purple coneflower called Echinacea to be wonderfully effective in fighting colds. Echinacea is among the most popular herbal supplements in North America, accounting for 10% of herbal sales in the U.S.

So why are some in the scientific community saying it doesn’t work?

How Controversy Over a Little Flower

It was a July 2005 study done at the University of Edmonton in Canada, published in the pages of the New England Journal of Medicine, that fueled the fire of controversy. On one side, there’s the community of people who take Echinacea to ward off colds and other respiratory tract infections (staying well or getting better quickly tends to make enthusiastic and loyal followers). On the other side is a spate of studies, culminating in the July 2005, giving the thumbs down to the flower’s healing powers.

The much-touted study was a placebo-controlled trial and was double-blinded (neither test group knew what they were taking). Healthy college students were given a dose of a rhinovirus infection, and were then sent to individual dorm rooms to take either an extract of Echinacea or a placebo. The results were disappointing to those of us expecting the scientific community’s “proof” to match ours—based on what our bodies and senses tell us. The study found no statistically significant difference between severity of symptoms or duration of the rhinovirus between the Echinacea and the control group. Why didn’t the study results match those of so many individuals?

What went wrong?

Noted herbalist and author Roy Upton states, [“The studies which found] positive results had dosages which were consistent with herbalist recommendations.”]

The University of Edmonton study didn’t.

Two oft-cited clinical trials in which positive results were found in the use of Echinacea for the common cold, both in vivo and in human volunteers, have been conducted by researchers Vinti Goel.

Tiny Doses, Minuscule Amounts of Active Herb

It is widely agreed among herbalists that the trial—also conducted by the team at the University of Alberta, Canada—published in the New England Journal of Medicine in July 2005 used radically smaller doses than those traditionally taken, doses so small they couldn’t possibly have worked. In the Turner trial, Echinacea extracts were given in doses of 1.5 ml tid, equivalent to 900mg daily, if the conductors of trial had consulted the real-life herbalist, say the natural health care community, they could have run a test that would have, well, tested something. The usual prescription dose for Echinacea taken by mouth ranges from 500 to 1,000 milligrams per day, and is taken three to five times a day, for seven days. This creates a range of 1500 to 5,000 mg per day. Most studies have shown Echinacea to have the greatest effectiveness when one starts taking it immediately upon feeling the early symptoms of coming down with a cold or virus.

Importantly, Echinacea has been proven in many tests, including those by Bauer and Wagner, Foster, and Hobbs, to have a supportive effect upon the immune system. That Echinacea stimulates Macrophages and killer cells is proven.

Sources:

Turner RB et al. New England Journal of Medicine, 2005 jul 28;353(4):341-8.

Upton R et al. Echinacea purpurea root: standards of analysis, Quality control, and therapeutics, American herbal pharmacopoeia, 2004

Goel v et al. Efficacy of standardized Echinacea preparation (echinilin) for the treatment of common cold: a randomized, double-blind, placebo- controlled trial. Journal of Clinical Pharmaceutical Therapy 2004: Feb,29(1):75-83.

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Date: December 23, 2005 12:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HERBAL EXTRACTS FOR IMMUNE SYSTEM SUPPORT

Nature’s Apothecary

"HERBAL EXTRACTS FOR IMMUNE SYSTEM SUPPORT AND DETOXIFICATION"

For years, Nature’s Apothecary’s reputation for producing high quality natural products, specifically multi-herb and single herb extracts and aromatherapy products, has been unparalleled. This family-owned, environmentally-conscious herbal extract company has laid deep roots on the front range of Colorado’s Rocky Mountains, and in the natural products industry as well. NOW® is proud to continue their tradition of excellence in providing only the highest quality natural herbal extracts with the purchase of this premier liquid herbal extract supplier. We’re committed to using the same processes and procedures that have made the Nature’s Apothecary line one of quality and longevity.

Nature’s Apothecary herbal extracts are created with pure herbs grown on small organic farms, or herbs that have been ethically hand-harvested with respect for the earth, just as herbalists have done for thousands of years. While the various herbs used in these formulations offer a broad range of health benefits, two of the most important are immune system enhancement and detoxification. Herbs have a long history of usefulness in these categories. There is evidence of the use of herbs by Stone Age humans, who either cultivated or gathered hundreds of herbs and plants for a variety of uses. The histories of various cultures are filled with references to the use of herbs. Ancient Sumerians, Egyptians, Romans, Greeks, Chinese, Europeans, and American Indians – all used herbs to heal and to nourish. Herbs that support the immune system and provide detoxification benefits were, and still are, very popular. Two of the most effective are Astragalus and Shiitake Mushroom.

Astragalus (Astragalus membranaceus) is a member of the legume family and is considered an adaptogenic herb in traditional Chinese medicine, where it has been safely used for centuries. Native to central and western Asia, specifically China, Korea and Taiwan, Astragalus offers a unique benefit found in very few herbs - it seems to selectively support immune system function by stimulating certain immune functions and depressing others. One reason is that Astragalus has a high selenium content, a trace element with documented immune system benefits. It also contains polysaccharides and flavonoids, which support healthy immune system function as well as minimizing the effects of free radicals on various membranes. The mechanisms of action through which Astragalus supports immune system function are varied. It has shown promise as a means to stimulate “resting” immune system cells, increasing their activity. Research shows that Astragalus supports the body’s production of immunoglobulins, Macrophages, T cells and natural killer (NK) cells, the grunts of the immune system’s army. Astragalus has been shown to support healthy cardiovascular function by protecting membranes from oxidative stress as a result of free radical damage.

Shiitake Mushroom (Lentinula edodes) is a culinary delight with some serious health benefits. The name Shiitake is from a combination of shiia, the Japanese word for a variety of chestnut tree, and take, the Japanese name for mushrooms.

Shiitake is also referred to as the Forest Mushroom and the Black Forest Mushroom. Indigenous to Eastern Asia, primarily Japan and China, Shiitake is Japan’s leading agricultural export, accounting for about eighty percent of the world’s Shiitake production. While it’s culinary reputation is well-known, Shiitake is also a medicinal herb with a long history of use. In traditional Chinese medicine (TCM), Shiitake is well-regarded and has been used to treat a variety of ailments. Modern research has shown that Shiitake supports healthy immune system function and cardiovascular health, primarily due to the naturally-occurring nutrients found in Shiitake. It contains an excellent B vitamin profile, as well as amino acids, protein, iron, and beta glucan, a major structural component in the cell walls of most fungi, including Shiitake. Beta glucan has been shown to support healthy immune system function by stimulating the activity of phagocytes, white blood cells and NK (natural killer) cells, vital components of the body’s immune system defenses. Astragalus and Shiitake Mushroom are just a few of the immune supporting herbal extracts to be found in the Nature’s Apothecary line. With over 250 SKU’s, Nature’s Apothecary is your best source for high-quality, effective herbal extracts.

References:
1) Balch, Phyllis A. Prescription For Herbal Healing, Avery, Penguin Putnam, 2002
2) Astragalus membranaceus. (Monograph), Thorne Research Inc., The Gale Group, 2003
3) Halpern, Georges M. & Miller, Andrew H. Medicinal Mushrooms: Ancient Remedies for Modern Ailments, M. Evans and Company, Inc. 2002
4) Longe, J.L. Shiitake Mushroom, Gale Encyclopedia of Alternative Medicine, 2001

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Date: December 08, 2005 10:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: AHCC® Fact Sheet - from Now Foods.

AHCC® Fact Sheet

LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity.

KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound)

MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on Macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product.

AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of Macrophages and cytokines, further strengthening the immune system.

This formula is suitable for vegetarians and is offered in Vcaps.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach.

COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6),

CAUTIONS: None.

PRODUCT SPECIFIC: None

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.

DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496.

Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315.

Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.

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AHCC and Vitanet Great Combination

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Date: December 07, 2005 05:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitaberry Plus + Super Fruit Antioxidant

Vitaberry Plus +™ Super Fruit Antioxidant

ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces Macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697

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Date: December 07, 2005 01:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immune Renew Fact Sheet

Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)

MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.

ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels

SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.

This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.
4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.
5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.
6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].
7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.
8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.
9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].
10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.
11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.
12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.
13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].
14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A Phase I/II Trial. J Med. 1998;29(5-6):305-30.
19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.
20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.
21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.
22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.
23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.
24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.
25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.
27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.
29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.
30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.
31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457
32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807
33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83. PMID: 15380649
34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.

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Date: November 11, 2005 06:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Q. How did researcher discover maitake’s health benefits?

Q. How did researcher discover maitake’s health benefits?

A. Because maitakes are well known as healthy food, researchers interested in medicinal mushrooms have studied them extensively. They discovered many maitake compounds with dramatic health-promoting potential. One of these compounds, maitake D-fraction, has particularly powerful anti-cancer effects.

In lab studies, D-fraction stops the growth of cancer cells and cancerous tumors. Maitake D-fraction stimulates the activity of two white blood cells, Macrophages and natural killer cells. These white blood cells then trigger the production of interleukins and other lymphokines, two biochemicals that help mediate the immune response. Maitake also inhibits some of the mechanisms that promote metastasis, or spread, of cancer cells in the lymph system and bloodstream.

Because of this success, maitake D-fraction is now being used in preliminary clinical trials of women with breast cancer. One study has reported significant improvement of symptoms, including reduction of the tumor. The maitake D-fraction was given to breast cancer patients in addition to standard chemotherapy.

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Date: November 11, 2005 05:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Effects of Cat's Claw on the immune system.

Q. What effect do the POAs from cat’s claw root have on our immune system?

A. Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.

Certain POAs help white blood cells called Macrophages work faster. The Macrophages’ job is to engulf and digest foreign material. This means that Macrophages can ingest more bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin, that is secreted by Macrophages. Interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals essential to an activated immune system. (90% of white blood cells are in reserve) POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists look at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies.

And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T-cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T-cells, Suppressor T-cells, and Killer T-cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.

European health care providers are often very comfortable integrating the use of herbal and nutritional supplements as vital components of their patients’ cancer treatments. In Austria alone, cat’s claw extract is used together with conventional treatment (chemotherapy, radiation, and/or surgery), to treat hundreds of cancer patients every year!

A recent clinical observational study looked at POA cat’s claw extract in 78 people with very advanced brain cancer. All of the participants reported that the special POA cat’s claw helped them feel better, have more vitality, and reduced side effects (such as nausea) caused by their conventional cancer treatment. The researchers felt the POA cat’s claw extract may also prove to have benefit in extending the life span of people with these types of deadly brain cancers.

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Date: October 18, 2005 12:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Results of GM Foods...

In a study in the early 1990’s rats were fed genetically modified (GM) Tomatoes, the rats refused to eat them. The rats were force fed and Several rats developed stomach leasions and seven out of 40 died within two weeks.

Whats is GMO?

GMO, Genetic Modified Organism, definition Genetic Modified Organisms according to the Gentechnikgesetz (GenTG)from 20.06.90 (Genetic Technique Law) in Germany are organisms whose genetical material were modified in a way which is not found in nature under natural conditions of crossbreed or natural recombination. The genetic Modified Organism must be a biological unit which is able to multiply itself or to transmit genetic material. Examples of modifications covered by this law are DNS recombination techniques in which vector systems are used; techniques by which genetic material prepared outside of the cell is introduced directly in the organism. These techniques include microinjection, Macroinjection and micro encapsulation, cell fusion as well as hybridization procedures by which living cells are formed with a new combination of genetic material using methods which are not found under natural conditions.

Rats fed GM corn had problems with blood cell formation and rats fed GM soy had problems with liver cell formation and livers of rats fed GM Canola had were heavy.

Cows in germany were fed GM Corn died with out reason and pigs fed GM corn became steril.

The more awareness a population has on GM foods the less the population trusts these types of foods, many Americans believe they have never eaten GM foods but little did they know they eat it daily, the long term effect of this sort of foods may take a decade of more to show up, do you want to take that chance? Not me.

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Date: October 10, 2005 11:52 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New antibiotics expected for resistant pneumonia bugs

New antibiotics expected for resistant pneumonia bugs

Scientists recently announced the expected arrival of a new family of bacteria-killers on the horizon for pneumonia and other diseases. These new antibiotics should offer an alternative to standard antibiotics, many of which have lost their punch against increasingly resistant germs.

The standard treatment today for many bacterial infections that cause respiratory diseases are medicines called Macrolides. These include well-known antiobiotics like penicillin and erythromycin. However, certain bacteria strains are growing resistant to them, as well as to the primary back-up medicines, known as quinolones.

The pharmaceutical industry's response to this problem is ketolides. Ketolides are derived from Macrolides, but since they have a different chemical composition, they will kill bacteria that are resistant to Macrolides. Researchers recently presented reports on two varieties of ketolides at an infectious diseases meeting sponsored by the American Society for Microbiology. Aventis Pharmaceuticals recently filed with the U.S. Food and Drug Administration to gain permission to sell a new ketolide antibiotic, Ketek, or telithromycin. A similar drug made by Abbott Pharmaceuticals, code named ABT-773, is also in the early stages of human testing.

Researchers presented new Ketek studies involving 2,500 patients. These reports intended to show how the once-a-day Ketek is equally effective as other standard antibiotics in treating many bacterial diseases, including pneumonia, bronchitis, sinus infections and sore throats. Scientist also say since the Ketek treatment lasts just five days, which is shorter than most antibiotic treatments, bacteria may be less likely to grow resistant to the new drug.

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Discount vitamins at Vitanet ®

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Date: October 03, 2005 03:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Oral Chelation with EDTA

Oral Chelation with EDTA

Cardiovascular Disease claims nearly 960,000 lives every year which is largely preventable and reversible.

What does heart disease really do to your body? Atherosclerosis (Hardened arteries) is a systemic condition (runs through out the body, brain, lungs, kidneys, and legs) where blood vesels get blocked and clogged. The blockages that lead to atherosclerosis can occur not only in large vessels sugeons can manipulate, but in the smaller blood vessels as well. Its in the smaller blood vessels and capillaries that the oxygen exchange to the tissue takes place.

You can protect the critical lifeline of oxygen that feeds and sustains the organs and tissues throughout your body including your heart. There is a treatment that moves plaque and restores blood flow throughout the entire arterial system, treating the micro as well as the Macro vessels. Its called EDTA chelation, available in oral supplementation. Oral chelation is safe and inexpensive therapy for your Cardiovascular system, if your family has a history of cardiovascular problems, don’t hesitate to try EDTA!

Traditional medicine uses one of two primary ways to open blocked arteries. The first is angioplasty, take a balloon and ream out the large arteries to clear blockages, there is a risk of heart attack or making the blockage worst, and this type of blockages usually return to normal size after a year. The second is cut away the blockage and put in new vessels usually stripped from your legs or other places in the body. If your doctor has recommended this second form of treatment you should be aware that mortality rate of this surgery is 4% - 10% and common side effects after the procedure is cerebral dysfunction—memory loss and mental decline.

EDTA can also treat heavy metal poisoning!

Back in world war II, men who worked in battery factories and men who painted ships with lead based paints began coming down with lead poisoning from their high exposure in these jobs. EDTA seemed to safely and effectively remove lead from the body and cure lead poisoning.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=807)

Date: July 27, 2005 12:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Strontium Bone Maker 60 VC - Strengthen Bones

Benefits

Helps maintain strong, healthy bones.*

In Vitro and Animal Studies

Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone remodeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the remodeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7

Clinical Trials

Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (Phase 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8

In another Phase 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10

Phase 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12

Safety

Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements.

Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed.

In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14

Scientific References

1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66.

2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53.

3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow Macrophage differentiation. Eur J Pharmacol 2002; 450:11-17.

4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79.

5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11.

6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9.

7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15.

8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31.

9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66.

10. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65.

11. Meunier PJ, Reginster JY. Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76.

12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19.

14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.

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Date: July 11, 2005 08:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HAWAIIAN NONI (Morinda citrifolia)

INTRODUCTION

In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to: