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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, Major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A Major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast Majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and Major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast Majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A Major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Does Methylation Effect Active Vitamin D3 Levels in the body?
Date:
July 08, 2026 12:43 PM
Yes, methylation directly and significantly impacts how efficiently your body converts Vitamin D3 into its active, usable form. This relationship operates on two distinct levels: epigenetic DNA methylation (which acts as a volume knob for the conversion enzymes) and the cellular methylation cycle (which shares a profound reciprocal feedback loop with active Vitamin D). To see exactly where methylation interferes, it helps to look at the standard two-step activation pathway:
1. DNA Methylation (The Epigenetic "Dimmer Switch")DNA methylation is an epigenetic mechanism where methyl groups are attached to a gene's promoter region, typically silencing or "turning down" its expression.
2. The Systemic Methylation Cycle Feedback LoopWhile S-adenosylmethionine (SAMe) is not a direct chemical cofactor required for the hydroxylation reactions themselves (which rely on NADPH and the cytochrome P450 enzyme network), the systemic methylation cycle and Vitamin D share a massive reciprocal cross-talk mechanism.
The Vitamin D "Non-Responder": Is Your DNA Dimming Your Supplement’s Power? Yes, higher active Vitamin D3 levels consistently cause homocysteine levels to drop. Large-scale observational studies and gold-standard randomized controlled trials (RCTs) confirm a distinct, inverse relationship: as your Vitamin D status optimizes, circulating total homocysteine decreases. When active D3 binds to the Vitamin D Receptor (VDR), it triggers specific genetic and cellular actions that clear homocysteine through multiple pathways. The Biological MechanismsActive Vitamin D doesn’t just lower homocysteine through one pathway; it exerts a multi-pronged push to keep the toxic amino acid from accumulating.1. Upregulation of Methionine Synthase (MTR)While active D3 supports the alternative BHMT (betaine) pathway, recent molecular research highlights an even more direct impact on the primary, folate-dependent remethylation loop.
2. Safeguarding Enzyme Function via Oxidative Stress ReductionThe primary enzyme responsible for clearing homocysteine, Methionine Synthase, is incredibly sensitive to oxidative stress. Under high inflammation or oxidative conditions, the cobalt atom at the heart of its B12 cofactor becomes oxidized, completely disabling the enzyme and causing a Major homocysteine backup.
3. Preserving Liver and Kidney FunctionThe alternative remethylation pathway, BHMT, operates almost exclusively in the liver and kidneys. If these organs experience structural or metabolic strain, their capacity to process homocysteine drops drastically. Active Vitamin D protects hepatic and renal tissue architecture, ensuring the local cellular machinery required for the betaine-homocysteine conversion remains functional.What the Clinical Trials ShowIn human trials, the drop isn't just theoretical - it's highly measurable.The Clinical Evidence: In double-blind, randomized, placebo-controlled trials, individuals with low baseline Vitamin D and elevated homocysteine were given high-dose Vitamin D3 (e.g., 50,000 IU weekly) over a two-month period. The treatment groups consistently showed statistically significant drops in total serum homocysteine, alongside reductions in body mass index (BMI) and systemic inflammatory markers, while the placebo groups saw no change. If someone is dealing with stubborn hyperhomocysteinemia (elevated homocysteine) and pushing hard on methylated B-vitamins (like methylfolate and TMG/betaine) without seeing their numbers budge, a hidden Vitamin D deficiency or a high-methylation genetic barrier at the CYP2R1 liver enzyme is very frequently the missing link. Summary: The relationship between Vitamin D3 activation and the body's biochemical pathways operates as a highly coordinated, reciprocal feedback loop. On an epigenetic level, DNA methylation acts like a cellular dimmer switch for the liver enzyme CYP2R1, which is responsible for converting raw D3 into its circulating form. When the promoter region of this gene is heavily methylated, enzyme production is suppressed, explaining why some individuals act as clinical "non-responders" who struggle to raise their blood levels even with high-dose supplementation. Once Vitamin D is successfully activated, however, it turns around and directly reinforces the systemic methylation cycle by binding to the Vitamin D Receptor (VDR) and upregulating the BHMT gene, which is vital for maintaining the body's universal methyl donor (SAMe) pool. Conversely, maintaining robust levels of active Vitamin D3 plays a direct, clinically proven role in forcing circulating homocysteine levels to drop. When active D3 binds to its receptor, it triggers a multi-pronged clearance strategy by activating the Nrf2 cellular defense pathway, which upregulates Methionine Synthase (MTR) - the primary enzyme that converts toxic homocysteine back into harmless methionine. Furthermore, by acting as a powerful systemic anti-inflammatory, active Vitamin D lowers the oxidative stress that would otherwise oxidize and disable the delicate B12 cofactors inside these clearance enzymes. This dual action of increasing enzyme production while shielding existing enzymes from environmental damage explains why clinical trials consistently show significant reductions in serum homocysteine when Vitamin D status is optimized.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6644) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6640)
Date:
April 15, 2026 02:04 PM
When you are under stress, your cells can become flooded with calcium, which "excites" the cell. Magnesium sits at the "gate," ensuring that only the necessary amount of calcium enters. Without enough magnesium, cells become hyper-excitable, leading to oxidative stress, inflammation, and even cell death. Furthermore, magnesium is a required co-factor for the production and stability of ATP (adenosine triphosphate), the primary energy currency of the cell. In fact, ATP is usually found in the body as a complex called Mg^2+-ATP.
However, many functional medicine experts argue this number is actually higher because the RDA is designed to prevent acute deficiency, not to optimize health. Furthermore, magnesium is stored in bones and soft tissue, not the blood, meaning standard "Serum Magnesium" blood tests often miss a deficiency until it is dangerously low.
Unlike Magnesium Oxide (which has poor absorption) or Magnesium Citrate (which can have a laxative effect), Magnesium Glycinate is chelated with the amino acid glycine. This makes it:
Here are the additional benefits you might notice once your magnesium "tank" is full:
Magnesium acts as the body's essential "biological coolant," stabilizing cellular integrity by regulating calcium influx and powering nearly every metabolic process as a co-factor for Mg^2+-ATP. Despite its critical role, more than half of the American population remains chronically deficient, a silent crisis fueled by mineral-depleted industrial soil and the stripping of nutrients during food processing. Transitioning to a high-quality supplement like Magnesium Glycinate offers a superior path to replenishment because its chelated form is both highly bioavailable and gentle on the digestive system. Once levels are restored, the systemic "re-tuning" manifests as a profound shift in well-being, ranging from enhanced sleep quality and stress resilience to improved bone density, hormonal balance, and DNA repair, effectively moving the body from a state of hyper-excitable stress to one of optimized physiological stability.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6637)
Date:
November 15, 2025 11:14 AM
Of course. The short-chain fatty acids (SCFAs) produced by your gut bacteria are powerful metabolites with wide-ranging, systemic benefits.
While there are three main SCFAs - Butyrate, Acetate, and Propionate - each has slightly different functions. Butyrate, in particular, is a superstar for gut health.
Here is a list of their most important benefits, categorized by body system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6628)
Date:
November 15, 2025 11:00 AM
Yes, absolutely!
Both inulin and acacia fiber are classic examples of prebiotic soluble fibers, and their primary mechanism is to feed beneficial gut bacteria, which in turn produce short-chain fatty acids (SCFAs), including butyrate.
Here’s a breakdown of how they compare to the berberine mechanism you mentioned.
As you noted, berberine isn't a fiber that bacteria ferment. Instead, it acts as a microbiome modulator:
Both pathways can lead to the same beneficial outcome - more of your body's own butyrate and other SCFAs.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6627)
Date:
November 05, 2025 03:58 PM
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6625)
Date:
June 11, 2024 05:22 PM
The spike protein has recently become a topic of Major concern, especially in light of the COVID-19 pandemic. Understanding what it is and how to manage its effects is crucial for overall health. In this article, we will explore what the spike protein is, its possible impacts on the body, and how natural substances like curcumin, bromelain, and nattokinase can help reduce its presence in the body.
The spike protein is a key component of the novel coronavirus SARS-CoV-2, which causes COVID-19. This protein is responsible for allowing the virus to enter human cells and initiate infection. The spike protein binds to receptors on the surface of human cells, facilitating the virus's entry and subsequent replication within the body. While the immune system typically destroys these proteins, lingering spike proteins can pose health risks, including inflammation and abnormal blood clotting.
Curcumin is a bioactive compound found in turmeric, a spice widely used in cooking and traditional medicine. This compound has powerful anti-inflammatory and antioxidant properties, making it a beneficial ally in combating various health issues, including the presence of spike proteins.
Curcumin works by modulating several biochemical pathways in the body. One of its primary functions is to inhibit pro-inflammatory cytokines and enzymes that contribute to inflammation. Additionally, curcumin boosts the activity of antioxidant enzymes, which helps neutralize harmful free radicals. By reducing inflammation and oxidative stress, curcumin can help minimize the damage caused by spike proteins.
To harness the health benefits of curcumin, it's best to incorporate turmeric into your diet or take curcumin supplements. Curcumin supplements often come in combination with piperine, a compound found in black pepper that enhances curcumin absorption. Curcumin is also combined with turmeric oil to enhance its absorption, consider using either one in supplement form to help the body rid itself of the spike protein.
Bromelain is a mixture of enzymes found in pineapples. Known for its anti-inflammatory and immune-modulating properties, bromelain can also help address the lingering effects of spike proteins.
Bromelain works by breaking down proteins and minimizing inflammation. It inhibits the production of pro-inflammatory cytokines, helping to reduce swelling and discomfort. The proteolytic (protein-digesting) enzymes in bromelain can also help to break down and clear spike proteins from the body.
Bromelain can be consumed through fresh pineapple or as a dietary supplement. If you opt for supplements, ensure that you follow the recommended dosage and consult your healthcare provider beforehand.
Nattokinase is an enzyme extracted from natto, a traditional Japanese dish made from fermented soybeans. This enzyme has gained attention for its ability to support cardiovascular health and promote the breakdown of fibrin, a protein involved in blood clotting.
Nattokinase helps to break down fibrin in the blood vessels, thereby preventing clots from forming. Additionally, this enzyme supports the degradation of spike proteins, potentially reducing the risk of clot-related issues. Nattokinase also helps to improve blood flow and enhance overall cardiovascular health.
Nattokinase is available in supplement form. When choosing a nattokinase supplement, look for a product with a high level of activity units, which measure enzymatic activity. Generally, nattokinase comes in 2000FU, and is taken 2 - 3 times daily.
Combining curcumin, bromelain, and nattokinase can provide a comprehensive approach to managing spike proteins in the body. Each of these natural substances works in different ways to reduce inflammation, enhance immune response, and clear harmful proteins. However, it's essential to adopt a holistic approach to health that includes a balanced diet, regular exercise, proper hydration, and adequate sleep.
Understanding and managing the presence of spike proteins in the body is vital for maintaining overall health. Natural compounds like curcumin, bromelain, and nattokinase offer promising benefits in reducing the harmful effects of these proteins. By incorporating these substances into your diet and following a holistic approach to wellness, you can support your body's natural defences and promote optimal health. So, it is essential to prioritize healthy habits and consider incorporating natural remedies as part of a comprehensive approach to maintaining good health.
Spike proteins play a significant role in the infection process of viruses, making it crucial to address their lingering effects in the body. Natural compounds like curcumin, bromelain, and nattokinase offer promising benefits in reducing inflammation and clearing spike proteins from the body. Additionally, adopting a balanced diet and lifestyle can support the effectiveness of these natural remedies in promoting overall health. By taking a holistic approach to wellness, we can work towards managing spike proteins and supporting our
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6615)
Date:
May 29, 2024 05:02 PM
Stevia has gained significant popularity as a natural sweetener, but with popularity comes a wave of misconceptions and myths. As consumers become more health-conscious and seek alternatives to sugar, it’s essential to separate fact from fiction regarding Stevia. This article debunks stevia myths with evidence-based info to clarify consumer doubts.
One of the most prevalent myths about stevia is that it is artificial. In reality, stevia is a completely natural sweetener derived from the leaves of the Stevia rebaudiana plant. The plant has been used for centuries by indigenous people in South America for its sweetening properties. Unlike artificial sweeteners such as aspartame or saccharin, stevia is derived from a natural source and processed to extract its sweet components, known as steviol glycosides.
Another common misconception is that stevia is harmful to health. Scientific studies and regulatory organizations have repeatedly confirmed the safety of stevia. The Food and Drug Administration (FDA) classifies high-purity stevia extracts as "Generally Recognized as Safe" (GRAS) for consumption. Furthermore, research indicates that stevia can have health benefits like lowering blood pressure and blood sugar levels, making it a suitable sweetener for individuals with diabetes and hypertension.
Some people believe that stevia has a bitter aftertaste, which makes it less appealing as a sweetener. While early formulations of stevia extracts indeed presented a noticeable bitter aftertaste, advancements in processing have minimized this issue. Modern high-purity stevia products are often combined with other natural sweeteners or flavor enhancers to improve taste, making them virtually indistinguishable from sugar in many applications.
While it’s true that stevia is an excellent sweetener for individuals managing diabetes due to its zero-calorie and zero-carbohydrate nature, it is not exclusive to them. Anyone looking to reduce sugar consumption or seeking a natural alternative can benefit from using stevia. It is a versatile sweetener that can be used in a variety of foods and beverages, making it suitable for the general population striving for a healthier lifestyle.
Not all stevia products are created equal. The purity and quality of stevia extracts can vary significantly between products. It's crucial to read labels and choose products that contain high-purity stevia extracts, as some products on the market contain added fillers or lower-grade stevia. By selecting reputable brands and scrutinizing ingredient lists, consumers can ensure they are using high-quality stevia that meets their health standards. Kal Sure Stevia Extract is one of those high-quality brands that stand out in the market. Known for its commitment to purity and potency, Kal Sure Stevia Extract offers a product that is free from fillers and unnecessary additives. The brand’s stringent quality control measures ensure that each batch contains only high-purity stevia extracts, delivering consistent sweetness without the aftertaste. Consumers can trust Kal Sure Stevia Extract as a safe, reliable, and pleasant-tasting alternative to conventional sugar. When choosing a stevia product, it's essential to opt for a brand like Kal Sure stevia to enjoy the full benefits of this natural sweetener.
Some believe that consuming stevia can trigger allergies. However, stevia is generally considered hypoallergenic and does not commonly cause allergic reactions. There have been few documented cases of stevia allergies, and these are typically related to individuals with specific sensitivities. For the vast Majority of people, stevia is a safe and well-tolerated sweetener, even for those with common food allergies.
The notion that stevia contributes to weight gain is counterintuitive, given its zero-calorie nature. Unlike sugar, which is high in calories and contributes to weight gain, stevia provides sweetness without adding calories. Using stevia instead of sugar can help reduce overall caloric intake, aiding in weight management efforts. Multiple studies have shown that replacing sugar with stevia can be an effective strategy for achieving and maintaining a healthy weight.
Concerns about stevia disrupting metabolism are unfounded. Research indicates that stevia neither affects metabolic rates nor alters insulin sensitivity in a negative manner. On the contrary, stevia has been shown to have a neutral or even beneficial impact on metabolism, particularly for individuals with metabolic disorders like diabetes. It allows for sweetening without the metabolic consequences associated with high sugar consumption.
There is a misconception that stevia is unsuitable for baking due to its chemical composition. While it is true that baking with stevia requires some adjustments—since it does not have the same physical properties as sugar—it can still be used effectively. Bakers often use stevia in combination with other ingredients to achieve the desired texture and sweetness. Many recipes and commercial products have successfully incorporated stevia, proving its versatility in baking applications.
Consumers sometimes think that switching to stevia will significantly increase their grocery bills. While high-purity stevia products may be more expensive per ounce than sugar, they are much sweeter. A small amount of stevia goes a long way, which means that even a small container can last a long time. In the long run, the cost of stevia can be comparable to or even less than sugar, particularly when considering the health benefits and potential medical cost savings from reduced sugar consumption. Brands like Kal Stevia 3.5 oz contains 1800 servings per container.
It is crucial to approach any information about stevia with a critical eye and rely on evidence-based data rather than myths. Stevia is a natural, safe, and versatile sweetener that offers numerous health benefits without the downsides of sugar and artificial sweeteners. By debunking these common misconceptions, consumers can make informed choices that contribute to a healthier lifestyle.
Now is the perfect time to reconsider your sweetening choices and embrace the benefits of stevia. With its proven safety, versatility in cooking, and numerous health advantages, stevia stands out as a superior alternative to traditional sugar and artificial sweeteners. Start exploring reputable brands, like Kal Sure Stevia Extract, and experiment with incorporating stevia into your daily routine. By making this simple switch, you can enhance your overall well-being without compromising on taste. Visit your local grocery store or trusted online retailer to find high-quality stevia products and embark on your journey to a healthier, sweeter life today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6605)
Date:
December 07, 2023 12:12 PM
Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a Major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
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Date:
November 10, 2022 11:53 AM
Most people know that fiber is important for maintaining a healthy digestive system. But did you know that soluble fiber can also have some pretty amazing benefits for your heart? Soluble fiber, which is found in abundance in psyllium seed husks, absorbs water in the intestines and forms a gel-like substance. This helps to reduce cholesterol levels and regulate blood sugar levels, both of which are important for maintaining a healthy heart. Let's take a closer look at how soluble fiber can benefit your heart health.
Reduces Cholesterol Levels
One of the main ways that soluble fiber benefits heart health is by reducing cholesterol levels. According to the American Heart Association, high cholesterol is a Major risk factor for heart disease. When cholesterol builds up in the arteries, it can narrow them and cause them to harden. This puts you at risk for heart attack and stroke. Psyllium husks are especially effective at reducing LDL (bad) cholesterol levels while also increasing HDL (good) cholesterol levels. This helps to keep your arteries clear and reduce your risk for heart disease.
Regulates Blood Sugar Levels
Another way that soluble fiber benefits heart health is by regulating blood sugar levels. High blood sugar levels can damage the nerves and kidneys, and it can also increase your risk for heart disease. By helping to regulate blood sugar levels, soluble fiber can help reduce your risk for developing these problems. Psyllium husks are especially effective at this because they slow down digestion and help food to be absorbed more slowly into the bloodstream. This helps to prevent spikes in blood sugar levels after meals.
If you're looking for a simple way to improve your heart health, then look no further than soluble fiber! Soluble fiber, which is found in psyllium husks, can help reduce cholesterol levels and regulate blood sugar levels. This helps to keep your arteries clear and reduce your risk for heart disease. So next time you're at the store, be sure to pick up some psyllium husks so you can start reaping the amazing benefits of soluble fiber!
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Date:
October 29, 2022 02:10 PM
Collagen is the most abundant protein in our bodies, and it's one of the Major building blocks of skin, hair, nails, bones, and joints. As we age, our bodies produce less and less collagen, which can lead to some unpleasant side effects. That's why it's important to get collagen in your diet, especially as you get older. Here's what you need to know about collagen and how to get more of it in your diet.
What is collagen?
Collagen is a protein that is produced by our bodies. It's made up of amino acids, which are the building blocks of proteins. There are 28 different types of collagen, but 90% of the collagen in our bodies is type I, II, or III. Collagen provides structure and support for our tissues and organs. It also helps with wound healing and plays a role in protecting our cells from damage.
Why do we need collagen?
As we age, our bodies produce less and less collagen. This can lead to wrinkles, joint pain, bone loss, muscle weakness, and other unwanted side effects. Getting enough collagen in your diet can help keep your skin looking young and healthy, reduce joint pain, improve bone density, increase muscle mass, and more. That's why it's so important to make sure you're getting enough collagen as you age.
One good source of collagen is bone broth powder. Bone broth powder is made from the bones and connective tissues of animals. It's a rich source of protein and other nutrients like calcium and magnesium. Bone broth powder can be mixed into soups or smoothies, or used as a base for cooking grains or vegetables. You can also find collagen supplements at most health food stores. These supplements are usually made from fish or bovine sources.
In Summary:
Collagen is an important protein that our bodies need for proper function. As we age, our bodies produce less collagen, which can lead to some unpleasant side effects like wrinkles, joint pain, and muscle weakness. Getting enough collagen in your diet is crucial for maintaining a healthy body as you age. Fortunately, there are plenty of ways to get more collagen in your diet. Bone broth powder is one good source of collagen; it's rich in protein and other nutrients like calcium and magnesium. You can also find collagen supplements at most health food stores. Making sure you're getting enough collagen in your diet will help you stay healthy well into your golden years!
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Date:
October 25, 2022 11:46 AM
Did you know that grape seeds are actually a potent source of antioxidants? NOW® Grape Seed Extract is a highly concentrated extract with a minimum of 90% polyphenols, including oligomeric proanthocyanidins (OPCs), which are the potent water-soluble free radical scavenging compounds found in grape seeds.* A growing body of research indicates that grape seed OPCs may help to support the health of vascular, bone, kidney, brain and other tissues by supporting a healthy, balanced immune response to oxidative and metabolic stress.*
The Antioxidant Power of Grape Seeds*
The natural world is full of antioxidants. These nutrients scavenge harmful toxins and byproducts that can damage cells, leading to inflammation. Inflammation is a Major contributing factor in numerous degenerative diseases, so it's important to do everything we can to keep it in check. Some of the best sources of antioxidants are fruits and vegetables—grape seeds included.
Grape seeds are an especially rich source of antioxidants due to their high concentration of polyphenols. Polyphenols are micronutrients that have been shown to have numerous health benefits.* NOW® Grape Seed Extract is a highly concentrated extract with a minimum of 90% polyphenols, including oligomeric proanthocyanidins (OPCs), which are the potent water-soluble free radical scavenging compounds found in grape seeds.* A growing body of research indicates that grape seed OPCs may help to support the health of vascular, bone, kidney, brain and other tissues by supporting a healthy, balanced immune response to oxidative and metabolic stress.*
What does this mean for your health? Preliminary research suggests that grape seed extract may support cardiovascular health, cognitive function, and healthy aging.* So if you're looking for a way to incorporate more antioxidants into your diet, consider giving grape seed extract a try!
In Summary:
NOW® Grape Seed Extract is a concentrated source of polyphenols—micronutrients shown to have numerous health benefits.* If you're looking for an easy way to incorporate more antioxidants into your diet, consider giving grape seed extract a try! *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
[*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.]
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Date:
October 18, 2022 03:07 PM
Garcinia cambogia is a plant native to SE Asia that has been used for centuries by traditional herbalists. Garcinia's primary bioactive constituent, Hydroxycitric Acid (HCA), has been extensively studied for its effects on citrate lyase, which is the main enzyme responsible for the cellular synthesis of fatty acids. Scientific studies indicate that in the presence of HCA, cells produce fewer fatty acids from carbohydrates. The active ingredient in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is extracted from the fruit’s rind. Hydroxycitric Acid is a natural substance that has demonstrated impressive weight loss results in scientific studies.
How Garcinia Cambogia Can Help You Lose Weight
Hydroxycitric Acid works by inhibiting the enzyme Citrate Lyase, which is responsible for converting unused carbohydrates into fat storage. By blocking this enzyme, HCA prevents unused carbohydrates from being stored as body fat and instead allows them to be used for energy production, which can lead to weight loss. In addition, Hydroxycitric Acid also acts as an appetite suppressant by increasing levels of serotonin, a brain chemical that promotes feelings of satiety and well-being.
The Benefits of Garcinia Cambogia
There are many benefits associated with taking Garcinia Cambogia extract, including weight loss, decreased appetite, and increased energy levels. However, perhaps the most impressive benefit of Garcinia Cambogia is its ability to help people lose weight without making any changes to their diet or lifestyle. This makes Garcinia Cambogia an ideal supplement for people who are looking to lose weight but don’t have the time or inclination to make Major changes to their habits.
If you’re looking for a natural way to lose weight without making any changes to your diet or lifestyle, then Garcinia Cambogia may be right for you. This supplement has been shown to block the enzyme Citrate Lyase, which is responsible for converting unused carbohydrates into fat storage. In addition, Hydroxycitric Acid also acts as an appetite suppressant by increasing levels of serotonin, a brain chemical that promotes feelings of satiety and well-being. So if you’re looking for an easy way to lose weight without diet or exercise, then give Garcinia Cambogia a try!
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Date:
September 10, 2022 09:31 AM
Recent scientific studies have shown that bacopa can support nervous system health by supporting the brain’s free radical protective systems. Bacopa is also a natural source of compounds called bacosides, which have been shown to support cognitive function and memory.
The many potential health benefits of bacopa are thought to be due to its unique chemical composition. Bacopa contains several different compounds that are known to support brain health, including beta-sitosterol, brahmine, herpestine, and saponins. Beta-sitosterol is a plant sterol that supports healthy cholesterol levels and cognitive function. Brahmine is a compound that has been shown to support memory and cognitive function. Herpestine is an anti-inflammatory compound that supports nervous system health. Saponins are plant compounds that have anti-inflammatory and antioxidant effects.
Bacopa also contains compounds called bacosides. Bacosides are thought to support cognitive function and memory by supporting the regeneration of nerve cells in the brain. Studies have shown that bacosides can help to repair damage caused by oxidative stress, which is thought to be one of the Major contributing factors to age-related cognitive decline.
Bacopa supplements are typically standardized to contain 50% bacosides. The recommended dosage of bacopa supplements is 300-600 mg per day. Bacopa supplements are generally well tolerated and side effects are rare. The most common side effect of taking bacopa is nausea, which typically goes away after a few days of taking the supplement.
In Summary:
Bacopa monnieri is an herb with a rich history of use in Ayurvedic medicine for supporting brain health.Recent scientific studies have confirmed many of the traditional uses of this herb and shown that it has significant potential for supporting cognitive function and memory. Bacopa supplements are generally well tolerated with few side effects reported. If you are looking for a natural way to support your brain health, consider giving bacopa a try!
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Date:
August 11, 2022 11:15 AM
If you're looking for a curcumin supplement that is highly absorbable by the body, look no further than CuraMed. With its patented BCM-95 turmeric essential oil process, CuraMed beats other supplements on the market when it comes to absorption. In fact, studies have shown that CuraMed is up to 10 times more absorbable than regular curcumin supplements! So if you're looking to get the most out of your curcumin supplement, make sure to choose CuraMed.
What is Curcumin and what are its benefits?
Curcumin is a yellow compound that is found in the spice turmeric. It has been used for centuries in Asian cuisine and traditional medicine. Curcumin has many potential health benefits, including reducing inflammation, boosting brain function, and fighting cancer. The anti-inflammatory effects of curcumin have been studied extensively. Curcumin is known to block inflammatory molecules, which can play a role in conditions like arthritis, heart disease, and Alzheimer's disease. The brain-boosting effects of curcumin are also well-documented. Curcumin has been shown to improve memory and increase levels of BDNF, a protein that helps to protect brain cells. Additionally, the potent antioxidant properties of curcumin may help to protect against the development of cancer. Although more research is needed, the potential health benefits of curcumin are very promising.
How is CuraMed different from other curcumin supplements?
CuraMed is a unique curcumin supplement that uses the patented BCM-95 process of manufacturing. This process increases the absorption of curcumin significantly and the turmeric essential oils extends the time at which the curcumin stays in the blood stream, making it more effective and longer lasting than other supplements on the market. In addition, CuraMed does not contain black pepper, which can cause stomach upset in some people. as a result, CuraMed is a more gentle and effective option for those looking to improve their health with curcumin. One can add bioperine which is standardized black pepper to increase absorption further.
How does the BCM-95 turmeric essential oil process increase absorbability?
BCM-95 is a patented process that significantly increases the absorption of curcumin, the active ingredient in turmeric. Curcumin is notoriously difficult to absorb, so this process is a Major breakthrough. BCM-95 uses the essential oils from the turmeric plant, which further increase absorption. This unique process results in a product that is absorbed up to 10 times better than standard curcumin supplements. In addition, BCM-95 maintains blood levels for up to 8 hours, while standard supplements only last for 2-3 hours. This makes BCM-95 the most effective turmeric supplement on the market today. If you're looking for a turmeric supplement that will give you maximum benefit, look for one that contains BCM-95.
Key Points:
In summary:
CuraMed is a highly absorbable curcumin supplement that uses the patented BCM-95 process to increase absorption by up to 10 times. This patented curcumin BCM-95 formula also help to maintain blood levels of curcumin for up to 8 hours, making it the most effective turmeric supplement on the market today. If you're looking for a way to improve your health with curcumin, CuraMed is definitely worth considering.
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Date:
July 08, 2022 12:42 PM
What is olive oil and where does it come from
Olive oil is a type of vegetable oil that is extracted from olives, the fruit of the olive tree. Olives are thought to originate from the Mediterranean region, and they have been cultivated for thousands of years. Olive trees are well-suited to the Mediterranean climate, and they produce a high quality of olive oil. The oil is then extracted from the olives using a cold-pressing process. This process helps to preserve the flavor and nutrients of the oil. Olive oil is a popular cooking ingredient, and it is also used in cosmetics and pharmaceuticals. It is a healthy source of fat, and it contains antioxidants that can protect against cell damage.
There are many benefits to using olive oil, both for cooking and for health. Olive oil is a healthy alternative to other oils, as it is lower in saturated fat and contains high levels of monounsaturated fat. In addition, olive oil contains antioxidants that can protect against cell damage. Some studies have also shown that olive oil can help to lower cholesterol levels and reduce the risk of heart disease. When used for cooking, olive oil can add flavor and depth to dishes. It is also a healthy way to cook, as it does not produce harmful chemicals when heated. Overall, olive oil is a versatile and healthy option that can be used in many different ways.
How olive oil can improve brain function
Recent studies have shown that olive oil can improve brain function. The main active ingredient in olive oil is oleocanthal, which is a powerful anti-inflammatory. Studies have shown that inflammation is a Major contributing factor to cognitive decline. By reducing inflammation, oleocanthal can help to improve brain function. In addition, olive oil also contains antioxidants, which can protect the brain from damage. These properties make olive oil an ideal food for people who are looking to improve their brain health.
The science behind olive oil and brain function
Olive oil is a healthy fat that has been shown to have numerous benefits for the body, including brain function. Numerous studies have shown that olive oil can help improve cognitive function and memory, as well as protect against age-related decline. The beneficial effects of olive oil on brain function are thought to be due to its high content of monounsaturated fatty acids, as well as its antioxidant and anti-inflammatory properties. Additionally, olive oil is a rich source of phenolic compounds, which have also been shown to boost cognitive function. To get the most benefit from olive oil for brain health, it is best to use extra virgin olive oil, which contains the highest levels of these beneficial compounds.
How to use olive oil for better brain health
There is growing evidence that olive oil can help to improve brain health. Numerous studies have shown that olive oil can help to protect the brain from age-related damage, and it may also have neuroprotective properties. One way to get the benefits of olive oil is to take a teaspoonful each day. This can help to increase levels of healthy fats in the brain, which are essential for cognitive function. Another option is to use olive oil when cooking. This can help to improve the absorption of nutrients from other foods, and it also provides a healthy source of calories. Also, your body needs fats to manufacture hormones. Either way, incorporating olive oil into your diet is a simple and effective way to boost brain health.
Olive oil a needed fat for the body to produce hormones.
While fat has gotten a bad rap in recent years, the truth is that our bodies need fat in order to function properly. Fats help to insulate our organs, protect our joints, and produce essential hormones. And while there are different types of fats, olive oil is one of the healthiest choices thanks to its high levels of monounsaturated fatty acids. These healthy fats can help to lower bad cholesterol levels and reduce the risk of heart disease. In addition, olive oil is a rich source of antioxidants, which can help to protect cells from damage. So next time you reach for that bottle of cooking oil, remember that olive oil isn’t just good for your health—it’s essential for it.
Olive oil is a healthy fat that has been shown to have numerous benefits for the body, including brain function. Numerous studies have shown that olive oil can help improve cognitive function and memory, as well as protect against age-related decline. The beneficial effects of olive oil on brain health are thought to be due to its high content of monounsaturated fatty acids, as well as its antioxidant and anti-inflammatory properties. Additionally, olive oil is a rich source of phenolic compounds, which have also been shown to boost cognitive function. To get the most benefit from olive oil for brain health, it is best to use extra virgin olive oil, which contains the highest levels of these beneficial compounds.
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Date:
April 30, 2022 10:02 AM
How can you reduce inflammation through diet?
There are many ways to reduce inflammation through diet, but perhaps the most important is cutting out processed foods and sugar. These foods contain inflammatory compounds known as advanced glycation end products (AGEs), which can aggravate existing inflammation or cause it to develop in the first place. In addition, studies have shown that eating a diet rich in vegetables and lean proteins can help to lower levels of inflammation throughout the body. Choosing whole grains, fruits, and healthy fats like olive oil is also a good way to support a body that is fighting against inflammation. In short, adopting a diet low in sugar and processed foods and high in fruits, vegetables, and lean protein can go a long way toward reducing inflammation both now and in the long term.
Supplements to take to reduce inflammation?
Inflammation is a natural and necessary part of our immune response, but if it becomes chronic or extreme, it can cause issues for our overall health. There are many different supplements that have been shown to be effective in reducing inflammation and promoting overall good health, including omega-3 fatty acids, Boswellia, pumpkin seeds, and turmeric. These nutrients work by interfering with the production of inflammatory hormones and enzymes, changing the chemical balance within our bodies and helping to reduce swelling and discomfort. Whether taken as a capsule or added to your diet through food sources like fish oil or ginger tea, these supplements can be an excellent way to boost your system's ability to fight inflammation. So if you're looking for ways to reduce inflammation and improve your overall well-being, consider adding these key nutrients to your daily routine.
The most effective anti-inflammatory supplements, Fish oil, Curcumin, and Boswellia!
While there are a number of different anti-inflammatory supplements on the market, some have proven to be more effective than others when it comes to reducing inflammation in the body. Perhaps the most commonly recommended supplement for this purpose is fish oil, which is rich in Omega-3 fatty acids, a type of polyunsaturated fat that has been shown to be especially effective in reducing inflammation. Another popular anti-inflammatory supplement is curcumin, which gives turmeric its signature yellow color and is thought to have antioxidant and anti-inflammatory properties. Additionally, another powerful anti-inflammatory agent is derived from the resin of Boswellia trees called Boswellia extract. All of these compounds have been shown to reduce inflammation in various scientific studies and can therefore be considered among the most effective anti- inflammatory supplements available today.
Tips for getting started on a anti-inflammatory diet?
When trying to get started on an anti-inflammatory diet, there are a few key strategies that can help make the process more successful. First, it is important to stock your pantry and fridge with plenty of healthy foods like fruits, vegetables, lean proteins, nuts, seeds, and reduce refined sugar intake as much as possible. These nutrient-dense foods are packed with essential vitamins and minerals that help to reduce inflammation and promote overall health.
Another key strategy to keep in mind when starting an anti-inflammatory diet is the use of supplements such as curcumin and CBD. These powerful compounds are believed to have anti-inflammatory effects in the body, helping to curb inflammation at its source vs. simply masking symptoms with painkillers or steroids. You can incorporate these supplements into your diet by taking them as pills or liquids or by incorporating them into your cooking through recipes like curried chicken or infused coconut oil tinctures.
The latest for calmness, relaxation, and to fight inflammation is CBD
CBD, or cannabidiol, has become increasingly popular in recent years as a natural solution for relieving stress, promoting relaxation, and managing inflammation in the body. Unlike THC, which is the psychoactive compound found in cannabis, CBD does not produce any high or altered state of consciousness. Instead, its many benefits are achieved through interactions with various receptors throughout the body, modulating mood and regulating pain response. As more and more people turn to CBD to achieve a sense of calm and well-being without depending on traditional pharmaceuticals, this powerful compound continues to gain widespread attention as a promising treatment option for everyday health issues. So if you're looking for a natural way to feel more mellow and at peace with yourself and your environment, consider giving CBD a try! With proven effects on everything from chronic pain management to improved sleep quality, this powerful all-natural remedy has something to offer everyone. Whether you're ready to give CBD a try for yourself or just curious about its many potential benefits, there's never been a better time than now to learn more about this exciting new approach to health and wellness.
Inflammation is one of the most common health concerns today, affecting people of all ages and backgrounds. While diet and lifestyle can be Major contributing factors like white sugar, there are also a number of dietary supplements that can help to reduce inflammation in the body. Curcumin, fish oil, and CBD are some of the most popular supplements for managing inflammation. These substances work by targeting key pathways involved in inflammatory responses, helping to prevent or reduce swelling and pain. They can be taken on their own or combined with other anti-inflammatory compounds for maximum effectiveness. Ultimately, whether you are trying to manage chronic illness or simply boost your overall health, using supplements such as curcumin, fish oil, and cbd can be a great way to go about it. So if you're looking for more tools to manage inflammation in your diet, these are certainly worth trying out.
Whatever methods you choose, remember that making small changes over time will be much more effective than trying to overhaul your lifestyle all at once. With a little patience and persistence, you can start down the path toward better health today! Let dietary supplements assist you in your goal to reduce inflammation each day for a life time!
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Date:
April 29, 2022 11:33 AM
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What is the liver and what does it do?
The liver is a large, multi-functional organ that plays a vital role in the body. Its primary function is to filter the blood and remove toxins, but it also helps to regulate metabolism, store nutrients, and produce bile. The liver is divided into two main lobes, the right lobe and the left lobe. The right lobe is slightly larger than the left lobe and includes the quadrate lobe and caudate lobe. The left lobe contains the left lateral section and the medial section. The hepatic veins drain blood from the liver and pass it through the inferior vena cava to be returned to the heart. The hepatic arteries supply oxygenated blood to the liver tissue, while the portal vein carries nutrient-rich blood from the digestive organs. The bile ducts transport bile produced by the liver cells to the gallbladder, where it is stored until needed for digestion.
The liver is a hardworking organ that performs many crucial functions in the body. By keeping it healthy, we can help to ensure that our entire body remains healthy and functioning properly.
What can damage the liver and how does that damage occur?
The liver is a vital organ that performs many important functions, such as filtering toxins from the blood and producing bile to help digest fats. However, the liver can be damaged by a number of different agents, including viruses, alcohol, and certain medications. Viruses such as hepatitis C and hepatitis B can cause inflammation of the liver, which can lead to scarring and eventually to liver failure. Alcohol abuse is also a Major cause of liver damage, as it can lead to fatty deposits, inflammation, and scarring. In addition, certain drugs (such as acetaminophen) can cause toxic damage to the liver cells. If the liver is not functioning properly, it can result in a build-up of toxins in the blood, which can lead to serious health problems.
Can the liver be repaired once it is damaged, and if so, how is that done?
The liver is a amazing organ. It is responsible for so many important functions in the body, from filtering toxins to producing bile to breaking down fats. When it is damaged, it can often repair itself. This is because the liver has a high regenerative capacity. hepatocytes, which are the main type of liver cell, can divide and grow back quickly when necessary. In fact, as long as about 25% of the liver remains healthy, it can regenerate itself completely over the course of a few weeks. There are a number of ways to damage the liver, such as through alcohol abuse or viral infections, but fortunately there are also ways to help it repair itself. Eating a healthy diet, getting enough exercise, and avoiding toxins, take liver supporting supplements like milk thistle and NAC can all support liver health and regeneration.
How can people prevent their livers from being damaged in the first place?
The liver is a vital organ that plays an important role in metabolism. However, the liver can also be easily damaged by alcohol, drugs, prescriptions, and environmental toxins, which are in the foods we eat. To help prevent liver damage, it is important to avoid excess alcohol consumption or avoid it all together, take medication as directed and if you are on medications that cause liver damage to discuss alternatives that do not harm the liver, and eat a healthy diet along with taking liver supporting supplements. Additionally, it is important to get regular exercise, as this helps to keep the liver healthy and functioning properly. By taking these steps, people can help to prevent liver damage and keep their organs healthy.
Are there any lifestyle changes or supplements that can help improve liver function even if it has been damaged already?
Liver damage is a serious concern for many people, as it can lead to a number of health problems. While there is no guaranteed way to reverse liver damage, there are some lifestyle changes and supplements that may help improve liver function. One potential change is to limit alcohol consumption, as alcohol is known to be damaging to the liver, mixing alchol and drugs can enhance the progress of liver damage. Additionally, eating a healthy diet and exercising regularly can help improve overall liver function. There are also a number of herbal supplements that are thought to be beneficial for the liver, such as milk thistle and dandelion root. However, it is important to speak with a healthcare provider before starting any new supplement, as some may interact with other medications.
What are the possible consequences of not repairing a damaged liver?
Liver damage can have serious consequences if left untreated. Depending on the cause, there may be a variety of negative effects that result from an injured liver. For example, if the damage is due to excessive alcohol consumption, then scarring and inflammation of the liver tissue can interfere with its ability to filter toxins out of the blood. This can lead to a host of potentially dangerous health problems, including nausea, chronic fatigue, jaundice, and cirrhosis. You must address the cause before change for the good can happen. In addition, unresolved inflammation can increase one's risk of developing more serious conditions such as cancer or heart disease. To prevent these possible consequences, it is important to seek medical attention as soon as possible after suffering from liver damage. This will allow doctors to properly diagnose the issue and develop an appropriate treatment plan. Addressing the cause is always preferable over simply treating symptoms alone. Ultimately, taking action now can help you protect your health in the future.
How can people find out if their livers need repair and where they should go for help if that is the case?
When it comes to liver health, there are a number of ways to find out if your liver needs some repairs. One method is to get tested for elevated liver enzymes, which are indicative of problems with the organ. You can also watch out for certain symptoms, such as fatigue, bloating or skin discoloration. If you notice any of these markers, you may want to consult with your doctor or a specialist in liver disease, who can help determine the best course of action. Depending on the underlying cause of your liver problem, treatment options may include changes to your diet and exercise habits, medications or even surgery in extreme cases. Whatever route you choose, it is essential that you address any issues with your liver as soon as possible in order to protect your overall wellbeing.
Generally, symptoms only show when liver function has dropped significantly.
Liver damage can often go undetected until it has reached a advanced stage. This is because the liver has an incredible capacity for regeneration and can continue to function even when up to 75% of it has been damaged. As a result, symptoms of liver disease often only become apparent when the organ has been severely compromised. By that point, the damage may be irreversible and serious complications may have developed. Therefore, it is important to be aware of the early signs of liver damage so that treatment can be started as soon as possible. These include fatigue, weight loss, abdominal pain, and yellowing of the skin and eyes.
Fortunately, Supplements like Milk thistle and NAC may help the body assist the liver in its repair.
The liver is a hardworking organ that is constantly exposed to toxins. As a result, it is susceptible to damage. Fortunately, supplements like milk thistle and NAC may help the body assist the liver in its repair. Milk thistle contains silymarin, a compound that helps to protect the liver from damage. NAC is an amino acid that helps to remove toxins from the liver. NAC also helps to replenish glutathione, a substance that plays a key role in liver detoxification. Together, these supplements can help to keep the liver healthy and functioning properly.
Whether you are looking for preventative measures to protect the liver or have an existing issue, it can never hurt to take either milk thistle, NAC, or both to support healthy liver function.
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Date:
April 27, 2022 11:53 AM
Did you know that N Acetyl Cysteine has been around for decades? This powerful supplement was first discovered in the 1950s and has been used as a remedy for many health issues since then. We will discuss the many benefits of N Acetyl Cysteine and how you can start using it to improve your health!
Glutathione and aging
As we age, our natural levels of glutathione tend to decline. This is a Major cause of many of the negative effects associated with the aging process, including reduced energy and slower recovery times after illness or injury. Fortunately, there are steps that we can take to increase our levels of glutathione, thus slowing down the aging process and keeping us feeling young and vibrant for longer. Some of these steps include eating a healthy diet rich in antioxidant-rich foods like fruits and vegetables, engaging in regular physical activity to improve circulation, and reducing stress levels through relaxation techniques like yoga and meditation. With these strategies in place, we can help to keep our bodies strong, boost our energy levels, and stay young well into old age. Fortunately, there is a supplement that could help, it is called N Acetyl Cysteine, this substance is a precursor to Glutathione and has been shown to boost glutathione levels.
What is N Acetyl Cysteine and what are its benefits?
N acetyl cysteine has been used as a supplement for many years, and its popularity is likely due to the many benefits it offers. The main function of this compound is to promote the production of glutathione, a powerful antioxidant that protects our bodies from oxidative stress and harmful free radicals. In addition, n acetyl cysteine has been shown to help reduce symptoms of certain mental health disorders, including anxiety and depression. Furthermore, studies have found that n acetyl cysteine may lower blood pressure and improve heart health by increasing blood flow and improving blood vessel function. Overall, it is clear that n acetyl cysteine has been an effective nutrient for many years and continues to be widely used by those looking for an easy way to support their health.
How can you start using N Acetyl Cysteine to improve your health?
N acetyl cysteine (NAC) is a powerful antioxidant that can help to protect cells from damage. It has been shown to be particularly effective in guarding against liver damage, and is often used as a treatment for hepatitis C. NAC can also help to improve lung function and relieve respiratory conditions such as bronchitis and asthma. In addition, NAC has been shown to boost levels of glutathione, which is a key molecule involved in detoxification. As a result, NAC can help to cleanse the body of harmful toxins and pollutants. NAC is available in supplement form, and can be taken orally or intravenously. It is generally well tolerated, with mild side effects such as nausea and vomiting occasionally reported. When taking NAC supplements, it is important to start with a lower dose and increase gradually as tolerated. Those with pre-existing medical conditions should always speak to their doctor before taking any new supplement. Overall, NAC is a safe and effective way to improve your health and protect your cells from damage.
What is the recommended daily dosage for N Acetyl Cysteine per day?
The standard recommended dosage for N-acetyl cysteine (NAC) is 600 mg per day. However, some studies have used dosages as high as 2,400 mg per day. The most common side effect of NAC is nausea, which can be minimized by taking the supplement with food. NAC is also sometimes used as a treatment for chronic bronchitis, and the recommended dosage for this condition is 1,200 mg per day. When used for this purpose, NAC is typically taken in divided doses of 600 mg twice per day. There is currently no consensus on the optimal dosage of NAC for any particular condition, and further research is needed to determine the ideal dosage for different applications. In acute circumstances, one might need 4000mg to 6000mgs daily in divided dosages, always work your way up to higher dosages as needed.
What are some of the most common uses for this supplement?
There are many different uses for NAC, or N-acetyl cysteine. This potent antioxidant supplement has been found to be effective in addressing a wide range of health concerns, including asthma and COPD, chronic sinusitis, liver disease, and particularly serious conditions such as cancer. Additionally, NAC has been shown to provide support for the immune system in general and may also serve as a detoxifying agent by helping to eliminate waste products like heavy metals from the body. Overall, there are numerous benefits to using NAC as part of a well-balanced diet. Whether you are looking to improve your respiratory health or strengthen your immune system, this versatile supplement can help you achieve your goals.
NAC composition
NAC, or N-acetyl cysteine, is a complex compound that is composed of various amino acids, including glutamate, glycine, and cysteine. These specific amino acids all play important roles in the function of NAC and affect its many beneficial properties. For example, glutamate increases metabolism and energy levels, while glycine promotes tissue healing and regeneration. Cysteine, on the other hand, facilitates the transport of oxygen and serves as a natural antioxidant. When taken together, these different components work synergistically to promote overall health and wellbeing by supporting key physiological processes such as digestion and immune response. Whether taken as a supplement or consumed through food sources like eggs and milk products, NAC is a versatile substance that is vital to many aspects of our daily health and well-being.
NAC and liver health
N-Acetyl-Cysteine (NAC) is a compound that has numerous benefits for liver health. Studies have shown that NAC can help to protect the liver from damage caused by alcohol and other toxins. It does this by helping to replenish levels of glutathione, a key antioxidant that helps to detoxify the liver. NAC also helps to reduce inflammation and improve blood flow to the liver. As a result, it can be an effective treatment for both acute and chronic Liver diseases. In addition, NAC has been shown to improve the overall health of people with Liver cirrhosis. Consequently, N-Acetyl-Cysteine is a compound that has many benefits for liver health and should be considered as part of any comprehensive treatment plan.
NAC, its sulfur content, and mucus elimination
NAC, or N-acetyl cysteine, is a sulfur-containing amino acid that plays an important role in mucus production and elimination. The sulfur content of NAC helps to thin mucus and make it less sticky, making it easier to clear from the lungs. In addition, NAC helps to break down mucus and remove it from the body. As a result, NAC is often used as a supplement to treat respiratory conditions such as bronchitis and chronic obstructive pulmonary disease (COPD). NAC is typically taken in the form of capsules or tablets, and the recommended dose depends on the individual. However, side effects are rare and generally mild, making NAC a safe and effective option for those seeking to improve their respiratory health.
N Acetyl Cysteine may lower blood pressure
One of these is its ability to lower blood pressure. A review of several studies found that N-acetyl cysteine was effective at reducing blood pressure in people with hypertension. In one study, participants who took N-acetyl cysteine had an average reduction in systolic blood pressure of 9.5 mmHg, compared to those who took a placebo. Other studies have shown similar results, suggesting that N-acetyl cysteine may be an effective treatment for high blood pressure. While more research is needed to confirm these findings, N-acetyl cysteine may offer a safe and natural way to lower blood pressure.
N Acetyl Cysteine may help blood clots - thrombosis
Blood clots are a necessary part of the body's natural healing process. They help to stop bleeding by sealing off damaged blood vessels. However, sometimes blood clots can form in healthy blood vessels, causing a potentially deadly condition called thrombosis. N Acetyl Cysteine is a compound that helps to break up blood clots and prevent thrombosis. It works by preventing the formation of a protein that is essential for clotting. In addition, N Acetyl Cysteine helps to improve the flexibility of blood vessels, making them less likely to rupture. As a result, this compound may help to reduce the risk of thrombosis and improve overall cardiovascular health.
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Date:
October 09, 2020 10:57 AM
Understanding the ECS
Some Endocannabinoids tell out body how much inflammatory messenger molecules to release or with hold. Others tell how fast to move food through the gastrointestinal tract. Still others tell the brain to release or hold neurotransmitters to calm the brain.
Age does Matter!
Aging is a Major contributor to a unhealthy ECS function. Lifestyle choices such as diet, exercise, exposure to toxins and stress impact and contribute to a declining ECS.
Any age can consume CBD and benefit from a balanced ECS. Take the plunge and try CBD today!
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Date:
January 22, 2020 09:36 AM
Since its discovery in 1992, researchers have been investigating the existence of a central regulatory system called the Endocannabinoid System (ECS).
The ECS is made of cannabinoid receptors, endogenous (Self-made) cannabis-like compounds and enzymes that create an inactivate them. The ECS is one of the most important physiologic systems involved in establishing and maintaining human health.
Phytocannabinoids like CBD, of which well over 100 have been found to exist, are plant derivatives that “talk” to just about every Major organ system in the body via the ECS, helping restore normal balance and physiologic homeostasis.
Endocannabinoids and their receptors are found throughout the body. In each tissue, cannabinoids perform different tasks, but the goal is always the same: homeostasis, maintaining a stable internal environment despite fluctuations in the external environment.
So, why is CBD important for the ECS? Because CBD modulates endocannabinoid tone and may help keep healthy people healthy.
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Date:
May 17, 2019 04:01 PM
One can treat poor mood and depression without using pharmaceutical drugs. One of these approaches involves using omega-3 fatty acid. Foods rich in this fatty acid can help. It has been shown by many scientific studies that the risk of having depression is reduced when one takes foods rich in omega-3 fatty acid. Some of the means that have been identified as the pathways in which omega-3 fatty acids work is that they can make the CNS to release more serotonin, they can reduce the risk of an inflammation and also its severity, and they can stop phosphatidyl-inositol from releasing hormones that make a person to have depressive moods. The way omega-3 fatty acids do this has been found to be similar to the way anti-depressant drugs work. Omega-3 fatty acids have been found to counter the release of serotonin in the brain that trigger depressive moods and they also have effect on the release of cytokines in the heart that relates to lowering the risk of one having coronary heart disease. And fortunately, heart disease is linked to major depressive moods. So, omega-3 fatty acid is a powerful compound that can be used to treat both problems. But what researchers have not agreed upon though is the required dosage of omega-3 fatty acid that a person should take each day to reap these benefits. Key Takeaways: "The fatty acids achieve their natural antidepressant effects through several means. Omega-3s can raise the activity of CNS seratonin, reduce the risk and severity of inflammation, and stop phosphatidyl-inositol from sending signals that bring about depressive moods." Read more: https://www.naturalnews.com/2019-04-15-omega-3s-are-a-potent-way-to-treat-depression.html
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Date:
May 09, 2019 04:37 PM
People who frequently experience bouts of anxiety and frequent periods of stress may find it hard to wind down after a hard day at work. This can then result in the inability to relax and inability to sleep. That is why anxiety and stress are recognized as the two most prominent leading causes of insomnia. Insomnia on the other hand takes a major toll on one’s physical health and mental well-being. What could be the solution? Researchers have found that this could be keeping a jasmine plant in the house. The scent which the jasmine plant releases has been linked to a reduction in anxiety and stress. The author states that the Jasmine plant is a flower that blooms at night with a sweet fragrance and exciting smell. Companies use it to make teas, incense, essential oils, and then perfumes. Its health benefits are immense and it has been used to treat diabetes, hepatitis, and cancer. It can now be proved that it can used to reduce anxiety and stress in individuals. It is estimated that about 40 million adults are affected yearly by anxiety and stress. The author then states the pathways in which jasmine works. Key Takeaways: "One way to combat a high level of toxins in the air is to keep a jasmine plant nearby. Research concludes a jasmine plant in your room can serve as relief for sleeplessness, anxiety, and stress, among other illnesses. Simply breathing the aromatic scent of the plant can help to significantly calm your anxieties." Read more: https://www.healthnutnews.com/keep-a-jasmine-flower-in-your-room-to-reduce-stress-and-anxiety-study-finds-its-as-calming-as-valium/
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Date:
May 09, 2019 09:51 AM
When one gets insufficient nutrients from the diet, taking multivitamins can be a healthy way to improve this. A recent study has shown that men who take multivitamins a lot are less prone to diseases related to the heart such as stroke and even death related to cardiovascular diseases. But how can cardiovascular diseases be prevented using multivitamins? There are few studies in this direction although a lot of studies have been done on the health benefits of multivitamins. That is why a team of researchers in the US embarked on a study of the incidence of multivitamin usage on major cardiovascular diseases like stroke, heart attack, and cardiovascular death. The study was a long term prospective study. The study was conducted between 1982 and 1995 using 18,530 healthy men that were aged from 40 years and above who the researchers followed. The participants reported their lifestyle habits and as well as their intake of certain foods. Throughout the follow up study, there were only 1,697 reported cases of cardiovascular diseases. This made the researchers to conclude that taking multivitamins means a reduced risk to cardiovascular diseases. It is then appropriate for one to choose the right kind of supplements to improve the diet. Key Takeaways: "In conducting the study, the research team followed 18,530 healthy men aged 40 years old or over from 1982 to 1995. The participants were initially enrolled from the Physicians’ Health Study I cohort" Read more: https://www.naturalnews.com/2019-04-16-multivitamins-keep-heart-disease-at-bay.html
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Date:
May 07, 2019 04:29 PM
It turns out that a lack of vitamin C in your diet can severely inhibit your body’s ability to absorb and use vitamin E. Vitamin E is important to a variety of cellular functions, as well as preventing heart disease and preventing arteries from becoming stiff and hard. The vast majority of Americans don’t eat enough vitamin E, and the situation is made worse by inadequate vitamin C consumption, since vitamin C protects and complements vitamin E. Good sources of these vitamins include kale, apples, carrots and walnuts, as well as supplements. Key Takeaways: "Plus, even if clinically-definable deficiencies are uncommon, too many people are still missing out on the key health benefits of vitamin E because they get insufficient amounts of it in their diet." Read more: https://www.naturalhealth365.com/vitamin-e-health-benefits-2914.html
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Date:
May 07, 2019 04:27 PM
Kava kava was found to alleviate anxiety symptoms by a study done at Gran Valley State University in Michigan. The study reported that it was safe if used for less than eight weeks. This medicine can be found in the Pacific and helps the many people suffering phobias and major depressive disorders. Approximately one in fourteen people suffer from some anxiety. The medicine was found to be harmful to the liver, and even toxic if taken longer than eight weeks. It was also found to be more effective for females and younger people. Longer term studies will be done to determine overall safety. In the meantime, other treatments include using skullcap, Valerian root, passion flower and Ashwagandha. Key Takeaways: "A lot of people suffer from anxiety. The World Health Organization (WHO) estimates that one in 14 people around the world has an anxiety disorder, making it one of the most common mental disorders." Read more: https://www.naturalnews.com/2019-03-13-kava-kava-can-alleviate-anxiety.html
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Date:
May 07, 2019 04:13 PM
Vitamin K2 may help protect you against becoming one of the 17 million people estimated to die from heart disease this year. Vitamin K2 helps to moderate how much calcium builds up in the body and where. This is significant because the calcification of plaque-narrowed arteries plays a major role in heart disease. Vitamin K2 can help ensure that your body’s calcium supply stays in your bones and out of your arteries and other soft tissue, and can reduce your risk of heart disease by 50 percent or more. Key Takeaways: "In one study, daily consumption of more than 32 micrograms of dietary vitamin K2 reduced the risk of arterial calcification and death from heart disease – by an incredible 50 percent." Read more: https://www.naturalhealth365.com/vitamin-k2-nutrition-news-2650.html
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Date:
May 06, 2019 03:30 PM
CBD oil has come into the spotlight recently with some amazing health benefits, so much so it is set to be sold in major retail pharmacy's such as CVS inthe very near future. CBD has many uses in the field of medicine, particularly as an over the counter remedy that if needed of long term, is safer than many of the current produces that are used as pain relievers, or that reduce anxiety and depression. One of the incredible things it does is to relieve cancer treatment symptoms, such as nausea and pain. It has also shown to improve neurological health and to stabilize blood sugars for those with diabetes. Key Takeaways: "Although the use of medical marijuana is still a politically and emotionally charged topic, research shows that there may be huge benefits of the CBD oil." Read more: https://www.longevitylive.com/live-healthier/7-proven-health-benefits-cbd-oil/
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Date:
May 06, 2019 03:18 PM
New Japanese research suggests that omega-3 fatty acids may help mitigate one of the major psychophysiological symptoms of PTSD: a racing, pounding heart. The researchers divided over 80 survivors of major accidents into a control group and a group that received supplementary omega-3s. The omega-3 group had lower resting heart rates and also lower heart rates after being subjected to imagery related to their accidents. Omega-3s play an important role in brain health and neurological functions, and have already displayed potential utility in the treatment of depression. Key Takeaways: "supplementation of omega-3s might help prevent psychophysiological symptoms of PTSD" Read more: https://www.naturalnews.com/2019-03-10-omega-3s-help-people-suffering-from-ptsd.html
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Date:
May 02, 2019 12:01 PM
Potassium is vital to the most basic functions of your body, including muscle function and your cells’ ability to take in and release fluids and nutrients. During pregnancy, it becomes even more important by helping to reduce fluid retention and fight unpleasant symptoms like restless legs and cramped, uncomfortable muscles. A potassium deficiency, also known as hypokalemia, is usually the result of a rapid, major loss of fluids, and can product symptoms such as soreness, cramps, stiffness and spasms in the muscles, breathing and digestive problems and more. Key Takeaways: "Potassium helps reduce fluid retention, combats electrolyte imbalance, and eases restless leg syndrome and cramps, all of which are major causes of discomfort during pregnancy." Read more: https://www.onegreenplanet.org/natural-health/potassium-and-pregnancy-everything-you-need-to-know/
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Date:
April 25, 2019 04:45 PM
The ketogenic diet is now trending across the globe, but many have many impressions about this eating regimen that are far from the truth. One of these myths surround the fact that keto dieters cannot consume any carbs at all, making the majority of fruits off limits. Keto followers can actually have up to 50 grams of carbohydrates to start, and they are encouraged to consume healthy fruits that are low in carbohydrates such as lemons or avocados. Key Takeaways: "Higher carb fruits are going to be harder to incorporate into a keto diet while still allowing room for the liberal intake of vegetables and avocados encouraged in the Keto Reset." Read more: https://www.marksdailyapple.com/fruit-keto/
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Date:
April 23, 2019 01:50 PM
Many people who are concerned in general terms about obesity still have gaps in their knowledge regarding several specific health consequences, according to the Cleveland Clinic Heart Health Survey. The survey indicated that, while most people understand that obesity is bad for cardiac health, they may not appreciate the role of triglycerides or different types of cholesterol. Likewise, relatively few respondents have made major dietary changes to try to lose weight, and my people appear not to understand that even relatively modest weight loss can have significant health benefits. Key Takeaways: "Carrying excess weight worsens glucose tolerance and also increases the risk of developing certain cancers." Read more: https://www.endocrineweb.com/news/obesity/61589-what-does-obesity-mean-your-health-heart-thyroid-diabetes
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Date:
April 16, 2019 10:53 AM
Metabolic syndrome involves a combination of at least three out of five conditions — hypertension, abdominal obesity, low “good cholesterol,” and excessively high fasting blood glucose and serum triglyceride scores. Metabolic syndrome is a major public health concern, given that more than a third of American adults have it. Recent studies suggest that eating too much saturated fat can imbalance the bacteria in the gut. This results over time in oxidative stress and inflammation that can deplete the body’s stockpiles of vitamins C and E, and also make it harder to absorb more vitamin C from food to replace what has been used up. Vitamins C and E play an important role in protecting against oxidative stress. Key Takeaways: "Around 35% of the American adult population has metabolic syndrome, with a higher prevalence in older age groups." Read more: https://www.medicalnewsbulletin.com/poor-gut-health-vitamin-c-e-metabolic-syndrome/
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Date:
April 09, 2019 10:19 AM
Type 2 diabetes is a major health concern, but the drugs healthcare professionals currently turn to are expensive and have negative side effects. As an alternative, researchers in Kenya have found that the spiny evergreen shrub Berberis holstii has anti-diabetic properties. It is traditionally used as a medicine against a wide variety of ailments. The researchers found that, in rats, the plant could reduce blood glucose level. Berberis holstii isn't the only alternative substance that has anti-diabetic properties, other plants/foods include fatty fish, leafy greens, cinnamon, eggs, chia seeds, and turmeric. Key Takeaways: "This spice reduces hemoglobin A1c, a marker of long-term blood sugar levels. It is also known to reduce cholesterol and triglyceride levels." Read more: https://www.naturalnews.com/2019-02-06-study-looks-at-anti-diabetes-properties-of-barberry-plant.html
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Date:
March 18, 2019 05:09 PM
Foods are often talked about for their health benefits, but little emphasis is ever placed on the mental health benefits of such foods. To reduce the stress in your life you need adaptogens into the diet. Adaptogens are herbs, spices, and mushrooms that can help relieve stress in a natural way. Ashwagandha is a powerful herb that is an antioxidant and aphrodisiac that helps with stress. The root is ground and ingested. Tulsi is another herb that is known for physical well being and can assist those with high anxiety. Two mushrooms, Reishi and Cordyceps, are very potent Adaptogens and reduce fatigue while reducing stress. It helps both physically and emotionally. Finally, the Indian gooseberry known as Amla is cheap and effective. High in vitamin C, it also enhances cognitive functions. Key Takeaways: "With stress being a major part of our lives today, it is imperative to make sure we get enough adaptogens into your diet." Read more: https://www.femina.in/wellness/diet/the-best-adaptogens-to-beat-stress-114667.html
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Date:
February 20, 2019 03:49 PM
The vast majority of women will suffer from common PMS symptoms like cramps, insomnia, headaches, anxiety and mood swings. Roughly five percent of women will suffer more serious symptoms — known as premenstrual dysphoric disorder — involving anger and depression. However, studies suggest that women who take a daily magnesium supplement suffer from less severe PMS symptoms, possibly because magnesium helps promote higher levels of gamma-Aminobutyric acid (GABA), a neurotransmitter which helps regulate sleep. Women who experience exhaustion as a central PMS symptom are particularly likely to need more magnesium. Key Takeaways: "According to PubMed Health, during this time, some women feel a wide range of physical discomforts, such as abdominal pain, abdominal cramping, backache, headaches, bloating, weight gain, breast tenderness, possible sleeping issues and digestive discomfort." Read more: https://www.dailymail.co.uk/health/article-6697649/Is-magnesium-secret-ending-PMS-Vitamin-eases-headaches-cramps.html
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Date:
February 20, 2019 01:17 PM
Broccoli can really help your body’s ability to expel harmful toxins that you ingest or breathe in According to recent research, post-menopausal women who ate lots of cruciferous vegetables like broccoli showed a substantially lower risk of breast cancer, perhaps because broccoli improved their livers’ ability to detoxify their bodies. Likewise, a 12-week Johns Hopkins University study of almost 300 people in a heavily polluted part of rural China found that broccoli made their bodies much more efficient at excreting dangerous compounds like benzene and acrolein. Key Takeaways: "These detoxifying benefits of broccoli can be attributed to the presence of phytonutrients called glucoraphanin, gluconasturtiian, and glucobrassicin." Read more: https://www.naturalnews.com/2019-02-12-broccoli-is-one-of-the-best-detoxifying-foods.html
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Date:
February 20, 2019 01:17 PM
The thyroid, a small gland at the base of the neck, receives TSH from the pituitary gland. This relationship, whether too active or not active enough, causes many adverse side effects. Too much TSH (hyperthyroidism) can cause: weight loss, cardiovascular irregularities, nervousness, and etc. Too little TSH (hypothyroidism) causes symptoms like: depression, impaired memory, hoarseness, fatigue, weight gain, etc. Currently, no cure exists for either of these conditions, other than individual specific diets targeted at raising or lower TSH levels. As always, one should consult a doctor and get proper blood work done before making any major life changes. Key Takeaways: "Thyroid problems can affect anyone of any age from infancy to the latest years of life." Read more: https://draxe.com/hyperthyroidism-vs-hypothyroidism/
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Date:
February 13, 2019 08:00 AM
Ginseng is a Chinese medicine, that has been long known for its medicinal properties. It is an expensive and scarce item. This makes it difficult to obtain for people who need it. Luckily, there is a solution to this problem. The Ginseng can be substituted by cultured roots of mountain ginseng. Studies have proven that mountain ginseng is a viable substitute. The general consensus of ginseng still holds, it have some risks as a supplement, but still has many health benefits. The article ends with a message to always consult a professional before taking ginseng as a supplement, just to be safe. Key Takeaways: "In particular, cultured roots from mountain ginseng tissue have been identified as viable replacements for larger and cheaper production of the highly sought-after ginseng roots." Read more: https://www.naturalnews.com/2019-02-06-mountain-ginseng-immunostimulating-antioxidant-anticancer-antiaging.html
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Date:
January 28, 2019 08:10 AM
There are so many people out there that are suffering from mental disorders. There have always been these types of people and the treatment for them has remained largely the same. They go and they talk to people who try to help them deal with their inner demons. However, it is really tough. Now, there are studies that are showing that curcumin and turmeric can actually help treat these individuals who have these disorders. This would be massive for them. Key Takeaways: "Thankfully, researchers have discovered that a compound in the popular Indian spice turmeric has the potential to effectively treat psychiatric disorders like bipolar disorder and depression." Read more: https://www.naturalnews.com/2018-12-06-accumulating-evidence-curcumin-turmeric-treat-psychiatric-disorders.html
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Date:
January 27, 2019 04:33 PM
Vegan diets are something that is really in fashion right now. Years ago, very few people were following vegan diets. People did not pay much attention to it but now, due to social media and marketing, these diets are getting more and more hype. As a result, you should try to make sure you are getting all the nutrients you need when on this diet. It is only natural for there to be some kind of nutrient deficiency when on this sort of meal plan. Key Takeaways: "Following a vegetarian or (the stricter) vegan lifestyle is rewarding, but it also comes with some challenges. Foregoing meat means you lose out on a major source of protein, but the list below includes other Paleo meat-free sources of this crucial nutrient." Read more: https://www.naturalnews.com/2018-12-08-best-vegan-friendly-protein-sources.html
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Date:
January 16, 2019 07:55 AM
The things that you put on your skin enter the bloodstream, so it is important to carefully think about the things that you'll use in your skin care regimen. One oil that can be applied to the skin that will benefit you when it is absorbed is rosehip. The powerful oil can enhance your skin in a plethora of ways and dermatologists agree that it is a product that people of all ages should use to keep their skin smooth, wrinkle-free, and looking great. Key Takeaways: "Here, exactly how rosehip oil benefits your skin and the easiest way to add it to your beauty routine." Read more: https://www.prevention.com/beauty/skin-care/a25596857/rosehip-oil-benefits/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5965)
Date:
January 08, 2019 09:58 AM
According to the Journal of Ayurveda and Integrative Medicine, Arjun Tree extract may have benefits for moderating your blood sugar and also your cholesterol levels. Diabetics are at dramatically higher risk of dying from heart conditions, perhaps because hyperglycemia tends to raise blood pressure and damage the circulatory system. The study in question focused on Wistar rats that received a high-fat diet, and found that Arjun Tree extract improved insulin sensitivity and liver triglycerides, and exhibited a pronounced anti inflammatory effect. Key Takeaways: "In this study, which was published in the Journal of Ayurveda and Integrative Medicine, the researchers were able to determine that Arjun tree extracts exhibit anti-hyperglycemic and anti-hyperlipidemic activity." Read more: https://www.naturalnews.com/2018-12-24-arjun-tree-lowers-blood-sugar-and-cholesterol-levels.html
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Date:
January 02, 2019 05:20 PM
Geranium is most often used as an essential oil, and researchers are finding that it has properties that can fight depression in struggling patients. They had a group of Swiss albino mice that they tested by giving geranium to them routinely through the study. The geranium was able to help produce serotonin, which is one of the leading ways that antidepressants work in aiding in the relief of depressive symptoms. The phytochemicals are what are responsible for this phenomena. Key Takeaways: "The National Alliance on Mental Illness estimates that nearly 20 percent of the U.S. adult population is diagnosed with major depressive disorder or anxiety." Read more: https://www.naturalnews.com/2018-12-22-geranium-has-antidepressant-and-anxiolytic-properties.html
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Date:
December 14, 2018 01:45 PM
There a ton of different ways in which someone can attempt to slow down the process of healing for their particular body. Everyone will age differently and it comes down to a lot of different things. Lifestyle, circumstance, and genetics are all major factors into how someone ages. However, you can better your chances of aging well if you really try to take your vitamins. Vitamin A is one that has been proven to help people in the aging process. Key Takeaways: "Taking vitamin A is not just good for improving and maintaining your eyes. It brings a host of health benefits involving many other important parts of the body." Read more: https://www.naturalnews.com/2018-12-09-vitamin-a-slows-down-aging.html
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Date:
November 13, 2018 08:51 AM
Living at maximum wellness constitutes more than having a disease-free body, where all the parts are doing what they should. Mental health is also a key component to overall health. From PMS symptoms all the way to psychotic episodes, more than 40 million U.S. citizens suffer from a mental problem yearly. Although treating these potentially life-clouding conditions with pharmaceutical grade interventions is the norm, these interventions are not without the possibility of potentially hazardous side effects. A B vitamin, inositol is present in the human brain in large amounts. Scientists are considering whether significant supplementation of the vitamin might be a way to treat an array of mental conditions naturally and without side effects. The vitamin has already been shown to have positive effect in some mental conditions, which makes sense, as significant neural transmissions depend on the use of the vitamin. Moreover, it's also been shown that individuals with lesser amounts of the mood-regulating chemicals, serotonin and dopamine, have lower levels of inositol. Although more research needs to happen in some instances, there is promising research to suggest that elevating inositol levels could prove efficacious for an array of mental conditions, including panic attacks, bipolar mood disorder, obsessive compulsive disorder and depression. Key Takeaways: "In fact, other major neurotransmitters depend on inositol to relay messages, making it a key component in a lot of chemical systems in a person’s brain, including the ability to handle stress, learning and cognition, mood, productivity, sleep, and addiction." Read more: https://www.naturalnews.com/2018-11-06-inositol-can-prevent-many-mental-health-disorders.html
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Date:
November 03, 2018 02:51 PM
There are a lot of different ways in which you can ensure that you stay whole and healthy. As a human, that should be your ultimate goal. If you are not healthy, or if you have major body parts that do not function as you wish, then you will see a massive issue. Vitamins are a good source of minerals for everyone. Now, the vitamin K2 is getting more limelight as people are saying it is very healthy. Key Takeaways: "As agricultural practices have shifted animals away from grassy pastures toward grains, K2 levels have decreased." Read more: https://www.dailykos.com/stories/2018/10/11/1803589/--Vitamin-K2-Steps-Into-the-Spotlight-for-Bone-and-Heart-Health
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Date:
October 27, 2018 11:51 AM
Lion's Mane Mushrooms are a delicious addition to any diet. Learning the many health benefits they offer only encourages the addition of the mushrooms to the diet. The list of benefits is certainly long and all users enjoy them. Benefits include improved memory, less symptoms of diabetes, improved brain function, fights dementia and other conditions, and tastes great. With such exciting benefits, it only pays to add the mushrooms to your diet without a moment of delay. Key Takeaways: "Research suggests that they may offer a range of health benefits, including reduced inflammation and improved cognitive and heart health." Read more: https://www.medicalnewstoday.com/articles/323400.php
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Date:
September 26, 2018 09:52 AM
According to recent research, people that consume a lot of processed sugars run a greater risk of developing Alzheimer's disease. What happens is the high sugar levels damage a major enzyme called macrophage migration inhibitory factor. Previous research has already shown that people with diabetes are more likely to develop this disease. However, the most recent research looked at brain samples of people with and without this disease and the process of glycation. It showed that glycation damages the essential enzyme which regulates insulin and the immune response. Key Takeaways: "Research has found that a high intake of processed sugar can raise the risk of Alzheimer’s disease." Read more: https://www.naturalnews.com/2018-09-12-eating-too-much-processed-sugar-increases-your-risk-of-alzheimers.html
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Date:
August 29, 2018 09:53 AM
Recent research by Natural Health 365 indicates that docosahexaenoic acid (DHA) may help mitigate the impact of a bad diet or excessive weight on your liver. This omega-3 fatty acid appears to help combat nonalcoholic steatohepatitis, a condition in which fat builds up in the liver and damages it over time. Since nonalcoholic steatohepatitis is a major precursor to cirrhosis and to the need for a transplant, this is a remarkably important benefit for the substantial population of obese adults and children. Key Takeaways: "An article on Natural Health 365 states that the omega-3 fatty acid can help mitigate the worst effects of liver damage, up to and including full-fledged liver disease." Read more: https://www.naturalnews.com/2018-08-27-dha-supports-liver-health-in-people-who-eat-a-poor-diet.html
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Date:
August 10, 2018 05:53 PM
Anandamide is a natural endocannabinoid produced in your body and found in certain foods that stimulates the same pleasure receptors as psychoactive THC. Anandamide and other endocannabinoids can help protect the brain from stress and damage, and encourage balanced moods and better consolidation of memories. The only two foods with large amounts of anandamide are (famously expensive) black truffles and chocolate, especially cacao powder and nibs, which are less processed. Several other foods, including black pepper, olive oil, grapes, broccoli, spinach and others can also raise your anandamide levels. Key Takeaways: "The “bliss molecule” is a natural neurotransmitter and endocannabinoid that creates a sense of happiness, an article on Be Brain Fit stated." Read more: https://www.naturalnews.com/2018-08-08-anandamide-is-a-natural-way-to-stimulate-a-sense-of-happiness.html
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Date:
August 09, 2018 09:53 AM
The scientific study of the analysis of CBD oil got a major push recently. It's been almost 40 years since the last thorough toxicological safety assessment was run on a CBD oil. However, recently CV sciences had AIBMR Life Sciences Inc. perform a complete array of toxicological studies on Plus CBD oil, the company's consumer-lauded hemp cannabidiol oil. The study attested to the safety of oral consumption of the product.
The study conclusions, which have been shared in a peer-reviewed journal, attest to the fact that the oil was discovered to be non-clastogenic, non-mutagenic and non-genotoxic. A spokesperson for CV Sciences noted that the company was "thrilled" and would encourage all CBD companies to allow such studies to be conducted for their own base materials. Key Takeaways: "The toxicological assessment is the first known published data of its kind since the 1980 Rosenkrantz et al.’s publication with respect to toxicology data on CBD, Cannabichromene and hashish oil." Read more: http://markets.businessinsider.com/news/stocks/cv-sciences-inc-announces-landmark-publication-on-the-toxicology-and-safety-assessment-of-base-material-of-its-pluscbd-oil-products-1027104828
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5701)
Date:
August 08, 2018 09:53 AM
Animal tissue trials suggest that humans can convert Omega 3 Fatty Acids into endocannabinoid compounds that fight inflammation without causing a high. These chemicals are distant relatives of the euphoria-inducing THC in marijuana. Enzymes in your body can process omega 3 and omega 6 fatty acids into compounds that bind to the cannabinoid system to boost immunity and fight inflammation. This results in the same medical effects as marijuana without the high. More research is needed, as the cannabinoid system may end up being one of the major endocrine systems in the body. Key Takeaways: "Cascading chemical reactions were revealed in animals tissues studies that convert omega-3 fatty acids into cannabinoids with anti-inflammatory benefits and lacking in psychotropic highs, as published in the Proceedings of the National Academy of Sciences." Read more: https://www.worldhealth.net/news/omega-3-fatty-acids-fighting-inflammation-cannabinoids/
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Date:
May 12, 2018 09:16 AM
If you are one of the millions of people battling depression, it is important that you understand the side effects that antidepressants oftentimes bring with them. These pills are the most common treatment for depression, but it does not come without its risks. Once you learn the potential risks that can come when taking these antidepressants, you may very well want to consider using some of the natural remedies for the mental health illness instead. Key Takeaways: "Many physicians and researchers have expressed concern that the benefits of these drugs simply don’t make up for the major side effects of antidepressants." Read more: https://draxe.com/side-effects-of-antidepressants/
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Date:
April 12, 2018 05:17 PM
Men are not as proactive as women in taking care of their health. One common problem men face is prostate problems, but 5 simple self care steps may help prevent problems before they arise. For the health of your prostate, consider the following lifestyle changes. Reducing stress, eliminating foods such as red meat, alcohol and processed foods from your diet, while adding foods rich in antioxidants. If you can't do this through diet consider using a targeted supplement for prostate health. And last, but never least, add exercise to your daily routine. Key Takeaways: "Easier said than done, but not making it any less important, stress is a key element that promotes and exacerbates prostate related issues. This stress can originate from many different areas, but most often stems from unhealthy relationships, job settings, and financial challenges." Read more: https://www.naturalnews.com/2018-04-10-5-undeniable-ways-to-protect-your-prostate.html
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Date:
April 11, 2018 01:17 PM
There are plenty of natural ways to fight aging. One Major way is Cucumbers. Cucumbers are high in silicon and Vitamin A. Vitamin A is key to eye health and skin care and silicon does the same. Silicon is mainly found in the skin and helps protect the plant. Adding this item to a simple juice with other natural items such as apples, carrots and herbs to flavor. This will keep you looking healthy and young for years to come.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5576)
Date:
March 19, 2018 01:18 PM
For many years, cultures have believed that there are zones in our feet that are connected to all the Major organs in our bodies. If we were to detox our bodies by soaking our feet in a variety of foot baths, they believed that any health issue could be cured. One of the most common detox bath is using hot water and epsom salt. If you added a cup of sea salt to the mixture and soak your feet until the water is dark you have a simple method of detoxing your body.
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Date:
February 18, 2018 03:59 PM
Many government and regulatory agencies around the world are warming up to the important medical benefits of cannabidiol, an oil compound derived from medicinal marijuana. But, even more surprisingly, one of the most strict anti-substance-use agencies in the world is turning its interest to the idea as well. The World Anti-Doping Agency, the arbiter of doping in sport and one of the strictest regulatory bodies around, has been taking testimonials from athletes regarding the potential usefulness of this substance. Key Takeaways: "Thanks to the World Anti-Doping Agency's (WADA) decision in September of last year, CBD is no longer a prohibited substance as of this year." Read more: https://www.inlander.com/spokane/even-the-world-anti-doping-agency-has-warmed-to-cbds/Content?oid=8135746
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Date:
February 07, 2018 07:59 AM
Gut bacteria are highly necessary for our well being, but what do you do when you take antibiotics to fight other bacteria? One major tip is only take them for as long as you need. This will allow you to still have a gut biota that is health, but maybe a bit knocked down thanks to this antibiotic. Take extra probiotics to seed your guy with good bacteria and maybe even take extra time to heal up and give them time to grow back and make you healthy again. Key Takeaways: "The best way to restore your gut to its pre-antibiotic glory is by eating lots of fibre-rich foods to fuel good bacteria growth." Read more: https://coach.nine.com.au/2018/01/31/12/29/antibiotics-gut-bacteria-microbiome
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Date:
February 06, 2018 03:59 PM
Flaxseeds, an ancient food and staple used for centuries, is hitting its stride as a health food. It has excellent properties for your body. One major is its high Omega-3 Fatty Acid content. This has been shown to help combat cancer by stopping malignant cells from sticking to each other and therefore spreading throughout the body. It can also help lower cholesterol and even help with hot flashes. Thanks to its antioxidants it may even help with skin health. Key Takeaways: "Flaxseeds are one of the most powerful plant seeds on the planet." Read more: http://www.newsworldindia.in/health-diet/flaxseeds-most-powerful-seeds-on-the-planet/287715/
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Date:
January 03, 2018 03:59 PM
Indiana is hoping to be one of the first states with legal access to CBD oil. Senator Jim Tomes from Wadesville out forth this legislation in hopes that it will open up this promising drug to all. The drug, derived from hemp, instead of the marijuana, is seen to be promising in many of its tests in a wide range of symptoms for its anti-inflammatory properties. The major change would just get rid of CBD from the controlled substance ban list for ease of use throughout the state. Key Takeaways: "Republican Sen. Jim Tomes from Wadesville hopes to make the product readily available throughout the state." Read more: http://www.wndu.com/content/news/Indiana-senator-files-bill-to-legalize-sale-possession-of-CBD-oil-467210573.html
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Date:
January 02, 2018 11:59 AM
High amounts of fluoride can be harmful to the development in children, especially in the prenatal stage of development. Most people get fluoride from their public water. Fluoride is added to water to aid in dental health. Studies have been done in Mexico that links high levels of fluoride intake affect the babies' development. China has also reported a similar study in the past that had similar outcomes. Constant excessive intake of fluoride also can cause yellowing of teeth and skeletal fluorosis. Key Takeaways: "The study found a drop in scores on intelligence tests for every 0.5 milligram-per-liter increase in fluoride exposure beyond 0.8 milligrams per liter found in urine." Read more: http://www.cnn.com/2017/09/19/health/fluoride-iq-neurotoxin-study/index.html
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Date:
December 27, 2017 03:59 PM
Probiotics have many benefits when given to newborns, especially those delivered by c-section. These probiotics when added to either brestmilk or formula help aid in digestion and replace many healthy bacteria that were not acquired due to the c-section. These probiotics helped relieve the onset of several ailments, making early life for the infant much easier and enables him to grow strong and have a better quality of life. Several studies were conducted to confirm this and it will be utilized more often I the future. Key Takeaways: "The study is extremely important in that it shows how important a healthy gut microbiome is. The work had major implications for reduced infection rates and atopic issues like eczema and asthma." Read more: https://www.naturalnews.com/2017-12-22-c-section-or-antibiotics-while-pregnant-give-babies-probiotics.html
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Date:
December 12, 2017 03:59 PM
Pesticides are needed to keep pests off of produce when it is growing, but ingesting these pesticides can be harmful to the health! Rather than risk your good health while trying to eat right, you can remove the pesticides from the produce quickly and easily, eliminating any worries. It is rather simple to remove pesticides off of your produce. Use one of these four tricks and pesticides on your produce is the least of your concerns. Key Takeaways: "But the vast majority of Americans have no real concept of just how toxic most fruits and vegetables really are." Read more: https://www.thealternativedaily.com/4-ways-to-remove-pesticides-naturally/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5434)
Date:
December 04, 2017 09:14 AM
A simple change to your morning coffee routine can have wide-ranging health benefits. Adding three simple ingredients- and switching out two others- will help combat inflammation, which has been linked to almost every major disease- from heart disease, cancer, and diabetes to Alzheimer's, depression, and even hair loss. A couple shakes of a mixture of turmeric, cinnamon, and just a little ground pepper (which helps your body to properly absorb the active ingredient in tumeric) is a great way to work anti-inflamatories into your daily routine, as well as add a nice flavor to your daily coffee. In addition, substituting sugar with raw honey and cream with coconut oil will add antioxidants, help you to absorb MORE antioxidants, and adds additional antifungal, antibiotic, and antibacterial properties (along with those contained in the spice mixture!) Evidence of anti-inflammatory (as well as other) benefits to these ingredients can be found in the journals "Cancer Prevention", "Evidence-Based Complimentary and Alternative Medicine" and "The Journal of Pharmacology and Experimental Therapeutics," as well as from the Arthritis Foundation. Key Takeaways: "Curcumin, the main compound found in turmeric, is widely known and accepted for its antioxidant, antiviral, antifungal and anti-inflammatory properties." Read more: https://www.thealternativedaily.com/i-drink-this-turmeric-coffee-recipe-every-day-to-fight-inflammation/
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Date:
November 25, 2017 07:59 AM
Type 3c diabetes is frequently being misdiagnosed as type 2 diabetes. This serious misdiagnosis is causing many patient to fall critically ill. As the doctor's treatment plan for type 2 diabetes isn't the right treatment path for type 3c diabetes. Type 3c diabetes is also called pancreatogenic diabetes. The inflammation and excessive tissue growth of the pancreas contribute to the onset of this serious condition. The wrong diagnosis can cause adverse medical conditions, both short and long term, for the patient involved. It is of vital importance that the medical profession inform themselves about this condition to avoid serious health risks from misdiagnosis to their patients. Key Takeaways: "Our research shows that the majority of people with type 3c diabetes are being misdiagnosed with type 2 diabetes, putting both their short and long term health at risk" Read more: https://www.naturalnews.com/2017-11-21-experts-warn-there-is-a-new-variant-to-metabolic-problems-type-3c-diabetes-is-being-misdiagnosed-which-is-why-many-arent-responding-to-treatment.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5415)
Date:
October 18, 2017 01:14 PM
First starting off giving a complete discription explaining what inflammation really is. The parts of the body it effects, and some things that can prevoke a reaction. Stating new information to help supside the pain helping live a normal life. After giving a personal Outlook on clean food, she provides a list showing inflammatory foods and other everyday items that we consume to try to avoid and a better alternative suggestions for someone who has inflammation. Key Takeaways: "It is no longer appropriate to allow our dietary habits to contribute to the morbidity and mortality of the majority of humans." Read more: http://www.dorchesterbanner.com/health-and-fitness/inflammation-101-get-smart-good-health/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5349)
Date:
October 15, 2017 10:14 AM
esophageal cancer is yet another kind of cancer which can have major negative effects on the body, but there is hope. Zinc supplements could make a difference, and there are other treatments as well. If you have this cancer you should at least try zinc. It's natural and is safer than many cancer medications. It won't hurt even if you don't notice a huge difference, but many are happy with the results from their trials of it. Key Takeaways: "It now appears that zinc and calcium can have a cross talk, meaning that they can be linked." Read more: https://www.naturalnews.com/2017-10-08-zinc-supplements-found-to-protect-against-esophageal-cancer.html
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Date:
October 12, 2017 01:14 PM
Male hair pattern baldness happens to 2 out of 3 men by the time they hit the age of 35. Genetics play a major role in your hair development over your lifetime. Nutrition plays a huge role too. Many people do not know that a diet consisting of healthy fats and protein will help fight off male hair pattern baldness. A diet consisting of high omega-3 fat like fish. Foods rich in Zinc are also helpful to fighting off male hair pattern baldness. Eat a diverse and healthy diet to maintain male hair pattern baldness. Key Takeaways: "By the age of 35, statistics indicate that two out of three average American men will have some form of hair loss — most likely male pattern baldness." Read more: http://www.thealternativedaily.com/eating-this-could-prevent-male-baldness/
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Date:
October 12, 2017 10:14 AM
Sugar has been known to be addictive for a while. The body and brain can begin to crave it. It can cause many health problems as well if it is not controlled. Be careful not to consume too much sugar if you want to remain healthy. Your body will thank you. Sugar negatively affects many parts of it including the teeth. Diabetes can occur if you overindulge as well. A weight problem can also occur. Key Takeaways: "Two hundred years ago, the average American ate 2 pounds of sugar per year. Today, we each eat about 152 pounds a year, according to the U.S. Department of Health and Human Services." Read more: https://www.theepochtimes.com/sugar-a-dangerous-and-addictive-drug_2320725.html
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Date:
October 11, 2017 01:14 PM
Having potassium in your diet regulates calcification of your arteries. Bananas have a lot of potassium, so people should eat plenty of those. Dietary potassium can help to prevent heart issues. Both bananas and avocados can protect against heart disease. They are both foods that are very high in potassium. This is something that the nation needs to pay attention to because a lot of deaths in this country are from heart disease. Potassium matters a lot. Key Takeaways: "Bananas and avocados -- foods that are rich in potassium -- may help protect against pathogenic vascular calcification" Read more: https://www.sciencedaily.com/releases/2017/10/171005102712.htm
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Date:
October 05, 2017 01:14 PM
There are 9 very good tips for better overall gut health. Having good gut health is a very important thing and is considered by many to be the foundation of good health. The gut plays a major role in many things, like our skin health and even our mental health. There are many different factors that can compromise the health of your gut. Processed foods and sugar are things that can hurt your gut and make it inefficient. Key Takeaways: "Many people screw their faces up at the thought of sauerkraut, but the truth is, it’s wonderful!" Read more: http://www.royalnews.com.ng/2017/09/26/9-top-tips-better-gut-health/
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Date:
September 25, 2017 12:14 PM
Obesity is a huge problem. More and more people suffer from it. It can lead to heart and other problems. There are things you can do such as eating right and exercising. Ginseng extract is also helpful. This extract has other health benefits as well so would be a great addition to anyone's health routine. Ginseng can also be found in some kinds of soda and other healthier drinks. There are many ways to take it in. Key Takeaways: "both groups noted significantly lower levels of abdominal and epididymal adipose tissue mass" Read more: http://www.naturalnews.com/2017-09-15-ginseng-extracts-found-to-prevent-obesity.html
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Date:
August 19, 2017 12:14 PM
Natural herbs have been used medicinally for centuries. Ancient civilizations have used them to cure many minor and major ailments. These herbs are now being studied to treat strains of cancer. Scientists from King Abdullah University of Science and Technology have reviewed the high contrast image screening of 52 herbs to test their properties that may affect cancer. In all of these 52 herbs three have showed promising results. They all originate in the middle east and include Citrullus colocynthis, Anastatica hierochuntica, and Juniperus phoenicea. More testing is necessary. With the discovery of these herbs' possible treatment powers, more people are hopeful to discover new herbs in such places as the Amazon Rainforest. Although recent deforestation is an issue. Key Takeaways: "The three plants that showed a lot of promise were Anastatica hierochuntica, Citrullus colocynthis, and Juniperus phoenicea. All of these had potent anti-cancer substances known as topoisomerase inhibitors that could potentially be used to develop anti-cancer inhibitors." Read more: http://www.naturalnews.com/2017-08-15-anti-cancer-breakthrough-52-herbs-were-tested-and-only-these-three-were-found-to-effectively-fight-cancer.html
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Date:
August 17, 2017 04:14 PM
Cannabis is a booming business right now. Colorado was a state that legalized marijuana back in 2012 and the revenue generated from legal marijuana sales has grown so much that it is now a rival of the GDP of a few island nations. The medical cannabis industry is is one of the major sectors being developed right now. People have known about the benefits for decades and only now are these claims being researched and understood better. Key Takeaways: "So far CBD oil has been found to treat addiction, inflammation, Multiple Sclerosis, epilepsy, mad cow disease, acne, diabetes, fibromyalgia, insomnia, PTSD, schizophrenia, Crohn’s disease, and many others." Read more: http://www.valuewalk.com/2017/08/cbd-oil/
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Date:
August 16, 2017 07:14 PM
Hemp Business Journal and Vote Hemp released a report indicating the United States based hemp industry sold $688 million worth of products in 2016. The industry is expected to continue with this successful trend, with estimates of $1.8 billion in sales by 2020. Various companies are capitalizing on this success and trying to expand their markets - for example, a Hemp Education Center is being established by ChineseHempOil.com, Inc., to provide information about the health benefits of hemp. Other organizations, like United Cannabis Corp, are leading the way in developing medical uses and therapies that utilize cannabinoids. Read more: CBD Products Play Major Role in the Legal Cannabis Industry
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Date:
August 15, 2017 12:14 PM
Many people in today's modern climate are looking for a new way to destroy and reverse the effects of their unhealthy eating habits. One major thing to look into is how to reverse cholesterol problems. HDL cholesterol is considered the "good" cholesterol, and therefore should be emphasized. One way of doing this that scientists have found, is to eat almonds. In a study, 48 adults had controlled for eating a small amount of almonds, and those that had them were found to return to healthy levels of HDL. Key Takeaways: "Eating almonds on a regular basis may help boost levels of HDL cholesterol while simultaneously improving the way it removes cholesterol from the body, according to researchers." Read more: http://news.psu.edu/story/476734/2017/08/10/research/almonds-may-help-boost-cholesterol-clean-crew
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Date:
August 06, 2017 07:14 AM
Green Gorilla is a CBD brand that has found tremendous success in North America as the health benefits of CBD are being uncovered more by the day. The success for this company has been so great, in fact, they are now operating in South America. Talk about a major transition, but one that is very well welcomed for Green Gorilla. Read this article to learn more about the new operations in South America, and what this means for the CBD industry. Read more: Green Gorilla's CBD Brand Establishes Operations in South America
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Bacopa monnieri is an herb that has been used by Ayurvedic herbalists for centuries. Also known as Brahmi, bacopa is native to India and has a long history of use in Ayurvedic medicine. In recent years, bacopa has gained popularity in the Western world as a natural supplement for supporting brain health. 
If you're like most people, you probably think of olive oil as a healthy cooking oil. But what you may not know is that olive oil has some amazing health benefits, including the ability to improve brain function. In this blog post, we will discuss the science behind olive oil and brain function and explore how this powerful oil can help improve your cognitive performance. 
Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that many people deal with on a daily basis. It can cause pain and discomfort in the body, and it can make everyday activities difficult to perform. Luckily, there are ways to reduce inflammation through diet. We will discuss the foods that you should eat and avoid if you want to reduce inflammation. We will also provide some helpful tips for getting started! 
The liver is a vital organ in the body that performs many essential functions. It can be damaged by a variety of factors, including disease, alcohol abuse, and exposure to toxic chemicals. Once the liver is damaged, can it be repaired? In this article, we will explore the answer to that question. We will also discuss the various ways that the liver can be damaged and how those damages can be repaired. 
